Even if you havent heard the term biohacking before, youve probably encountered some version of it. Maybe youve seen Twitter CEO Jack Dorsey extolling the benefits of fasting intermittently and drinking salt juice each morning. Maybe youve read about former NASA employee Josiah Zayner injecting himself with DNA using the gene-editing technology CRISPR. Maybe youve heard of Bay Area folks engaging in dopamine fasting.

Maybe you, like me, have a colleague whos had a chip implanted in their hand.

These are all types of biohacking, a broad term for a lifestyle thats growing increasingly popular, and not just in Silicon Valley, where it really took off.

Biohacking also known as DIY biology is an extremely broad and amorphous term that can cover a huge range of activities, from performing science experiments on yeast or other organisms to tracking your own sleep and diet to changing your own biology by pumping a younger persons blood into your veins in the hope that itll fight aging. (Yes, that is a real thing, and its called a young blood transfusion. More on that later.)

The type of biohackers currently gaining the most notoriety are the ones who experiment outside of traditional lab spaces and institutions on their own bodies with the hope of boosting their physical and cognitive performance. They form one branch of transhumanism, a movement that holds that human beings can and should use technology to augment and evolve our species.

Some biohackers have science PhDs; others are complete amateurs. And their ways of trying to hack biology are as diverse as they are. It can be tricky to understand the different types of hacks, what differentiates them from traditional medicine, and how safe or legal they are.

As biohacking starts to appear more often in headlines and, recently, in a fascinating Netflix series called Unnatural Selection its worth getting clear on some of the fundamentals. Here are nine questions that can help you make sense of biohacking.

Depending on whom you ask, youll get a different definition of biohacking. Since it can encompass a dizzying range of pursuits, Im mostly going to look at biohacking defined as the attempt to manipulate your brain and body in order to optimize performance, outside the realm of traditional medicine. But later on, Ill also give an overview of some other types of biohacking (including some that can lead to pretty unbelievable art).

Dave Asprey, a biohacker who created the supplement company Bulletproof, told me that for him, biohacking is the art and science of changing the environment around you and inside you so that you have full control over your own biology. Hes very game to experiment on his body: He has stem cells injected into his joints, takes dozens of supplements daily, bathes in infrared light, and much more. Its all part of his quest to live until at least age 180.

One word Asprey likes to use a lot is control, and that kind of language is typical of many biohackers, who often talk about optimizing and upgrading their minds and bodies.

Some of their techniques for achieving that are things people have been doing for centuries, like Vipassana meditation and intermittent fasting. Both of those are part of Dorseys routine, which he detailed in a podcast interview. He tries to do two hours of meditation a day and eats only one meal (dinner) on weekdays; on weekends, he doesnt eat at all. (Critics worry that his dietary habits sound a bit like an eating disorder, or that they might unintentionally influence others to develop a disorder.) He also kicks off each morning with an ice bath before walking the 5 miles to Twitter HQ.

Supplements are another popular tool in the biohackers arsenal. Theres a whole host of pills people take, from anti-aging supplements to nootropics or smart drugs.

Since biohackers are often interested in quantifying every aspect of themselves, they may buy wearable devices to, say, track their sleep patterns. (For that purpose, Dorsey swears by the Oura Ring.) The more data you have on your bodys mechanical functions, the more you can optimize the machine that is you or so the thinking goes.

Then there are some of the more radical practices: cryotherapy (purposely making yourself cold), neurofeedback (training yourself to regulate your brain waves), near-infrared saunas (they supposedly help you escape stress from electromagnetic transmissions), and virtual float tanks (which are meant to induce a meditative state through sensory deprivation), among others. Some people spend hundreds of thousands of dollars on these treatments.

A subset of biohackers called grinders go so far as to implant devices like computer chips in their bodies. The implants allow them to do everything from opening doors without a fob to monitoring their glucose levels subcutaneously.

For some grinders, like Zoltan Istvan, who ran for president as head of the Transhumanist Party, having an implant is fun and convenient: Ive grown to relish and rely on the technology, he recently wrote in the New York Times. The electric lock on the front door of my house has a chip scanner, and its nice to go surfing and jogging without having to carry keys around.

Istvan also noted that for some people without functioning arms, chips in their feet are the simplest way to open doors or operate some household items modified with chip readers. Other grinders are deeply curious about blurring the line between human and machine, and they get a thrill out of seeing all the ways we can augment our flesh-and-blood bodies using tech. Implants, for them, are a starter experiment.

On a really basic level, biohacking comes down to something we can all relate to: the desire to feel better and to see just how far we can push the human body. That desire comes in a range of flavors, though. Some people just want to not be sick anymore. Others want to become as smart and strong as they possibly can. An even more ambitious crowd wants to be as smart and strong as possible for as long as possible in other words, they want to radically extend their life span.

These goals have a way of escalating. Once youve determined (or think youve determined) that there are concrete hacks you can use by yourself right now to go from sick to healthy, or healthy to enhanced, you start to think: Well, why stop there? Why not shoot for peak performance? Why not try to live forever? What starts as a simple wish to be free from pain can snowball into self-improvement on steroids.

That was the case for Asprey. Now in his 40s, he got into biohacking because he was unwell. Before hitting age 30, he was diagnosed with high risk of stroke and heart attack, suffered from cognitive dysfunction, and weighed 300 pounds. I just wanted to control my own biology because I was tired of being in pain and having mood swings, he told me.

Now that he feels healthier, he wants to slow the normal aging process and optimize every part of his biology. I dont want to be just healthy; thats average. I want to perform; thats daring to be above average. Instead of How do I achieve health? its How do I kick more ass?

Zayner, the biohacker who once injected himself with CRISPR DNA, has also had health problems for years, and some of his biohacking pursuits have been explicit attempts to cure himself. But hes also motivated in large part by frustration. Like some other biohackers with an anti-establishment streak, hes irritated by federal officials purported sluggishness in greenlighting all sorts of medical treatments. In the US, it can take 10 years for a new drug to be developed and approved; for people with serious health conditions, that wait time can feel cruelly long. Zayner claims thats part of why he wants to democratize science and empower people to experiment on themselves.

(However, he admits that some of his stunts have been purposely provocative and that I do ridiculous stuff also. Im sure my motives are not 100 percent pure all the time.)

The biohacking community also offers just that: community. It gives people a chance to explore unconventional ideas in a non-hierarchical setting, and to refashion the feeling of being outside the norm into a cool identity. Biohackers congregate in dedicated online networks, in Slack and WhatsApp groups WeFast, for example, is for intermittent fasters. In person, they run experiments and take classes at hacklabs, improvised laboratories that are open to the public, and attend any one of the dozens of biohacking conferences put on each year.

Certain kinds of biohacking go far beyond traditional medicine, while other kinds bleed into it.

Plenty of age-old techniques meditation, fasting can be considered a basic type of biohacking. So can going to a spin class or taking antidepressants.

What differentiates biohacking is arguably not that its a different genre of activity but that the activities are undertaken with a particular mindset. The underlying philosophy is that we dont need to accept our bodies shortcomings we can engineer our way past them using a range of high- and low-tech solutions. And we dont necessarily need to wait for a double-blind, randomized, placebo-controlled trial, traditional medicines gold standard. We can start to transform our lives right now.

As millionaire Serge Faguet, who plans to live forever, put it: People here [in Silicon Valley] have a technical mindset, so they think of everything as an engineering problem. A lot of people who are not of a technical mindset assume that, Hey, people have always been dying, but I think theres going to be a greater level of awareness [of biohacking] once results start to happen.

Rob Carlson, an expert on synthetic biology whos been advocating for biohacking since the early 2000s, told me that to his mind, all of modern medicine is hacking, but that people often call certain folks hackers as a way of delegitimizing them. Its a way of categorizing the other like, Those biohackers over there do that weird thing. This is actually a bigger societal question: Whos qualified to do anything? And why do you not permit some people to explore new things and talk about that in public spheres?

If its taken to extremes, the Whos qualified to do anything? mindset can delegitimize scientific expertise in a way that can endanger public health. Luckily, biohackers dont generally seem interested in dethroning expertise to that dangerous degree; many just dont think they should be locked out of scientific discovery because they lack conventional credentials like a PhD.

Some biohacks are backed by strong scientific evidence and are likely to be beneficial. Often, these are the ones that are tried and true, debugged over centuries of experimentation. For example, clinical trials have shown that mindfulness meditation can help reduce anxiety and chronic pain.

But other hacks, based on weak or incomplete evidence, could be either ineffective or actually harmful.

After Dorsey endorsed a particular near-infrared sauna sold by SaunaSpace, which claims its product boosts cellular regeneration and fights aging by detoxing your body, the company experienced a surge in demand. But according to the New York Times, though a study of middle-aged and older Finnish men indicates that their health benefited from saunas, there have been no major studies conducted of this type of sauna, which directs incandescent light at your body. So is buying this expensive product likely to improve your health? We cant say that yet.

Similarly, the intermittent fasting that Dorsey endorses may yield health benefits for some, but scientists still have plenty of questions about it. Although theres a lot of research on the long-term health outcomes of fasting in animals and much of it is promising the research literature on humans is much thinner. Fasting has gone mainstream, but because its done so ahead of the science, it falls into the proceed with caution category. Critics have noted that for those whove struggled with eating disorders, it could be dangerous.

And while were on the topic of biohacking nutrition: My colleague Julia Belluz has previously reported on the Bulletproof Diet promoted by Asprey, who she says vilifies healthy foods and suggests part of the way to achieve a pound a day weight loss is to buy his expensive, science-based Bulletproof products. She was not convinced by the citations for his claims:

What I found was a patchwork of cherry-picked research and bad studies or articles that arent relevant to humans. He selectively reported on studies that backed up his arguments, and ignored the science that contradicted them.

Many of the studies werent done in humans but in rats and mice. Early studies on animals, especially on something as complex as nutrition, should never be extrapolated to humans. Asprey glorifies coconut oil and demonizes olive oil, ignoring the wealth of randomized trials (the highest quality of evidence) that have demonstrated olive oil is beneficial for health. Some of the research he cites was done on very specific sub-populations, such as diabetics, or on very small groups of people. These findings wouldnt be generalizable to the rest of us.

Some of the highest-risk hacks are being undertaken by people who feel desperate. On some level, thats very understandable. If youre sick and in constant pain, or if youre old and scared to die, and traditional medicine has nothing that works to quell your suffering, who can fault you for seeking a solution elsewhere?

Yet some of the solutions being tried these days are so dangerous, theyre just not worth the risk.

If youve watched HBOs Silicon Valley, then youre already familiar with young blood transfusions. As a refresher, thats when an older person pays for a young persons blood and has it pumped into their veins in the hope that itll fight aging.

This putative treatment sounds vampiric, yet its gained popularity in the Silicon Valley area, where people have actually paid $8,000 a pop to participate in trials. The billionaire tech investor Peter Thiel has expressed keen interest.

As Chavie Lieber noted for Vox, although some limited studies suggest that these transfusions might fend off diseases like Alzheimers, Parkinsons, heart disease, and multiple sclerosis, these claims havent been proven.

In February, the Food and Drug Administration released a statement warning consumers away from the transfusions: Simply put, were concerned that some patients are being preyed upon by unscrupulous actors touting treatments of plasma from young donors as cures and remedies. Such treatments have no proven clinical benefits for the uses for which these clinics are advertising them and are potentially harmful.

Another biohack that definitely falls in the dont try this at home category: fecal transplants, or transferring stool from a healthy donor into the gastrointestinal tract of an unhealthy recipient. In 2016, sick of suffering from severe stomach pain, Zayner decided to give himself a fecal transplant in a hotel room. He had procured a friends poop and planned to inoculate himself using the microbes in it. Ever the public stuntman, he invited a journalist to document the procedure. Afterward, he claimed the experiment left him feeling better.

But fecal transplants are still experimental and not approved by the FDA. The FDA recently reported that two people had contracted serious infections from fecal transplants that contained drug-resistant bacteria. One of the people died. And this was in the context of a clinical trial presumably, a DIY attempt could be even riskier. The FDA is putting a stop to clinical trials on the transplants for now.

Zayner also popularized the notion that you can edit your own DNA with CRISPR. In 2017, he injected himself with CRISPR DNA at a biotech conference, live-streaming the experiment. He later said he regretted that stunt because it could lead others to copy him and people are going to get hurt. Yet when asked whether his company, the Odin, which he runs out of his garage in Oakland, California, was going to stop selling CRISPR kits to the general public, he said no.

Ellen Jorgensen, a molecular biologist who co-founded Genspace and Biotech Without Borders, two Brooklyn-based biology labs open to the public, finds antics like Zayners worrisome. A self-identified biohacker, she told me people shouldnt buy Zayners kits, not just because they dont work half the time (shes a professional and even she couldnt get it to work), but because CRISPR is such a new technology that scientists arent yet sure of all the risks involved in using it. By tinkering with your genome, you could unintentionally cause a mutation that increases your risk of developing cancer, she said. Its a dangerous practice that should not be marketed as a DIY activity.

At Genspace and Biotech Without Borders, we always get the most heartbreaking emails from parents of children afflicted with genetic diseases, Jorgensen says. They have watched these Josiah Zayner videos and they want to come into our class and cure their kids. We have to tell them, This is a fantasy. ... That is incredibly painful.

She thinks such biohacking stunts give biohackers like her a bad name. Its bad for the DIY bio community, she said, because it makes people feel that as a general rule were irresponsible.

Existing regulations werent built to make sense of something like biohacking, which in some cases stretches the very limits of what it means to be a human being. That means that a lot of biohacking pursuits exist in a legal gray zone: frowned upon by bodies like the FDA, but not yet outright illegal, or not enforced as such. As biohackers traverse uncharted territory, regulators are scrambling to catch up with them.

After the FDA released its statement in February urging people to stay away from young blood transfusions, the San Francisco-based startup Ambrosia, which was well known for offering the transfusions, said on its website that it had ceased patient treatments. The site now says, We are currently in discussion with the FDA on the topic of young plasma.

This wasnt the FDAs first foray into biohacking. In 2016, the agency objected to Zayner selling kits to brew glow-in-the-dark beer. And after he injected himself with CRISPR, the FDA released a notice saying the sale of DIY gene-editing kits for use on humans is illegal. Zayner disregarded the warning and continued to sell his wares.

In 2019, he was, for a time, under investigation by Californias Department of Consumer Affairs, accused of practicing medicine without a license.

The biohackers I spoke to said restrictive regulation would be a counterproductive response to biohacking because itll just drive the practice underground. They say its better to encourage a culture of transparency so that people can ask questions about how to do something safely, without fear of reprisal.

According to Jorgensen, most biohackers are safety-conscious, not the sorts of people interested in engineering a pandemic. Theyve even generated and adopted their own codes of ethics. She herself has had a working relationship with law enforcement since the early 2000s.

At the beginning of the DIY bio movement, we did an awful lot of work with Homeland Security, she said. And as far back as 2009, the FBI was reaching out to the DIY community to try to build bridges.

Carlson told me hes noticed two general shifts over the past 20 years. One was after 2001, after the anthrax attacks, when Washington, DC, lost their damn minds and just went into a reactive mode and tried to shut everything down, he said. As of 2004 or 2005, the FBI was arresting people for doing biology in their homes.

Then in 2009, the National Security Council dramatically changed perspectives. It published the National Strategy for Countering Biological Threats, which embraced innovation and open access to the insights and materials needed to advance individual initiatives, including in private laboratories in basements and garages.

Now, though, some agencies seem to think they ought to take action. But even if there were clear regulations governing all biohacking activities, there would be no straightforward way to stop people from pursuing them behind closed doors. This technology is available and implementable anywhere, theres no physical means to control access to it, so what would regulating that mean? Carlson said.

Some biohackers believe that by leveraging technology, theyll be able to live longer but stay younger. Gerontologist Aubrey de Grey claims people will be able to live to age 1,000. In fact, he says the first person who will live to 1,000 has already been born.

De Grey focuses on developing strategies for repairing seven types of cellular and molecular damage associated with aging or, as he calls them, Strategies for Engineered Negligible Senescence. His nonprofit, the Methuselah Foundation, has attracted huge investments, including more than $6 million from Thiel. Its aim is to make 90 the new 50 by 2030.

Wondering whether de Greys goals are realistic, I reached out to Genspace co-founder Oliver Medvedik, who earned his PhD at Harvard Medical School and now directs the Kanbar Center for Biomedical Engineering at Cooper Union. Living to 1,000? Its definitely within our realm of possibility if we as a society that doles out money [to fund research we deem worthy] decide we want to do it, he told me.

Hes optimistic, he said, because the scientific community is finally converging on a consensus about what the root causes of aging are (damage to mitochondria and epigenetic changes are a couple of examples). And in the past five years, hes seen an explosion of promising papers on possible ways to address those causes.

Researchers who want to fight aging generally adopt two different approaches. The first is the small molecule approach, which often focuses on dietary supplements. Medvedik calls that the low-hanging fruit. He spoke excitedly about the possibility of creating a supplement from a plant compound called fisetin, noting that a recent (small) Mayo Clinic trial suggests high concentrations of fisetin can clear out senescent cells in humans cells that have stopped dividing and that contribute to aging.

The other approach is more dramatic: genetic engineering. Scientists taking this tack in mouse studies usually tinker with a genome in embryo, meaning that new mice are born with the fix already in place. Medvedik pointed out thats not very useful for treating humans we want to be able to treat people who have already been born and have begun to age.

But he sees promise here too. He cited a new study that used CRISPR to target Hutchinson-Gilford progeria syndrome, a genetic disorder that manifests as accelerated aging, in a mouse model. It wasnt a total cure they extended the life span of these mice by maybe 30 percent but what I was very interested in is the fact that it was delivered into mice that had already been born.

Hes also intrigued by potential non-pharmaceutical treatments for aging-related diseases like Alzheimers for example, the use of light stimulation to influence brain waves but those probably wont help us out anytime soon, for a simple reason: Its not a drug. You cant package and sell it, he said. Pharma cant monetize it.

Like many in the biohacking community, Medvedik sounded a note of frustration about how the medical system holds back anti-aging progress. If you were to come up with a compound right now that literally cures aging, you couldnt get it approved, he said. By the definition weve set up, aging isnt a disease, and if you want to get it approved by the FDA you have to target a certain disease. That just seems very strange and antiquated and broken.

Not everyone whos interested in biohacking is interested in self-experimentation. Some come to it because they care about bringing science to the masses, alleviating the climate crisis, or making art that shakes us out of our comfort zones.

My version of biohacking is unexpected people in unexpected places doing biotechnology, Jorgensen told me. For her, the emphasis is on democratizing cutting-edge science while keeping it safe. The community labs shes helped to build, Genspace and Biotech Without Borders, offer classes on using CRISPR technology to edit a genome but participants work on the genome of yeast, never on their own bodies.

Some people in the community are altruistically motivated. They want to use biohacking to save the environment by figuring out a way to make a recyclable plastic or a biofuel. They might experiment on organisms in makeshift labs in their garages. Or they might take a Genspace class on how to make furniture out of fungi or paper out of kombucha.

Experimental artists have also taken an interest in biohacking. For them, biology is just another palette. The artists Oron Catts and Ionat Zurr from the University of Western Australia were actually the first people to create and serve up lab-grown meat. They took some starter cells from a frog and used them to grow small steaks of frog meat, which they fed to gallery-goers in France at a 2003 art installation called Disembodied Cuisine.

More recently, Alexandra Daisy Ginsberg has used old floral DNA to recreate the smell of flowers driven to extinction by humans, enabling us to catch a whiff of them once more.

And this summer, a London museum is displaying something rather less fragrant: cheese made from celebrities. Yes, you read that right: The cheese was created with bacteria harvested from the armpits, toes, bellybuttons, and nostrils of famous people. If youre thoroughly grossed out by this, dont worry: The food wont actually be eaten this bioart project is meant more as a thought experiment than as dinner.

When you hear about people genetically engineering themselves or trying young blood transfusions in an effort to ward off death, its easy to feel a sense of vertigo about what were coming to as a species.

But the fact is weve been altering human nature since the very beginning. Inventing agriculture, for example, helped us transform ourselves from nomadic hunter-gatherers into sedentary civilizations. And whether we think of it this way or not, were all already doing some kind of biohacking every day.

The deeper I delve into biohacking, the more I think a lot of the discomfort with it boils down to simple neophobia a fear of whats new. (Not all of the discomfort, mind you: The more extreme hacks really are dangerous.)

As one of my colleagues put it to me, 40 years ago, test tube babies seemed unnatural, a freak-show curiosity; now in vitro fertilization has achieved mainstream acceptance. Will biohacking undergo the same progression? Or is it really altering human nature in a more fundamental way, a way that should concern us?

When I asked Carlson, he refused to buy the premise of the question.

If you assert that hackers are changing what it means to be human, then we need to first have an agreement about what it means to be human, he said. And Im not going to buy into the idea that there is one thing that is being human. Across the sweep of history, its odd to say humans are static its not the case that humans in 1500 were the same as they are today.

Thats true. Nowadays, we live longer. Were taller. Were more mobile. And we marry and have kids with people who come from different continents, different cultures a profound departure from old customs that has nothing to do with genetic engineering but thats nonetheless resulting in genetic change.

Still, biohackers are talking about making such significant changes that the risks they carry are significant too. What if biohackers upgrades dont get distributed evenly across the human population? What if, for example, the cure for aging becomes available, but only to the rich? Will that lead to an even wider life expectancy gap, where rich people live longer and poor people die younger?

Medvedik dismissed that concern, arguing that a lot of interventions that could lengthen our lives, like supplements, wouldnt be expensive to produce. Theres no reason why that stuff cant be dirt-cheap. But that depends on what we do as a society, he said. Insulin doesnt cost much to produce, but as a society weve allowed companies to jack up the price so high that many people with diabetes are now skipping lifesaving doses. Thats horrifying, but its not a function of the technology itself.

Heres another risk associated with biohacking, one I think is even more serious: By making ourselves smarter and stronger and potentially even immortal (a difference of kind, not just of degree), we may create a society in which everyone feels pressure to alter their biology even if they dont want to. To refuse a hack would mean to be at a huge professional disadvantage, or to face moral condemnation for remaining suboptimal when optimization is possible. In a world of superhumans, it may become increasingly hard to stay merely human.

The flip side of all this is the perfect race or eugenics specter, Jorgensen acknowledged. This is a powerful set of technologies that can be used in different ways. Wed better think about it and use it wisely.

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Josiah Zayner is a biohacker whos famous for injecting himself with the gene-editing tool CRISPR. At a time when the technology exists for us to change (or hack) our own DNA, what are the ethics of experimenting on ourselves, and others, at home? On the launch episode of this new podcast, host Arielle Duhaime-Ross talks to Zayner about how hes thinking about human experimentation today. Plus: new efforts to come up with a code of conduct for biohackers, from legislation to self-regulation.

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What is biohacking? The new science of optimizing your brain and body. - Vox.com