6 hours ago
Johns Hopkins researchers have discovered an unexpected phenomenon in the organs that produce sperm in fruit flies: When a certain kind of stem cell is killed off experimentally, another group of non-stem cells can come out of retirement to replace them.
The discovery sheds light on the tiny "environments" that stem cells occupy in animal bodies and may help explain how stem cells in tumors replenish themselves, the researchers report in the May 8 issue of the journal Cell Reports. Damage of the kind duplicated in the laboratory occurs naturally after exposure to radiation and perhaps also after ingestion of toxic chemicals such as those used in chemotherapy.
The research group, led by Erika Matunis, Ph.D., a professor of cell biology at the Johns Hopkins University School of Medicine, has been using the fruit fly as a model living system in which to study stem cells in their natural state. Most stem cell research is done on cells grown in the laboratory, but in real life, stem cells reside in tissues, where they are sequestered in tiny spaces known as niches. Adult stem cells keep dividing throughout life to make various kinds of cells, like new blood cells and germ cells.
Matunis's group studies such niches in fruit fly testes, the sperm-producing organs shaped like a coiled tube whose end houses a niche. In the niche are three kinds of cells: germ line stem cells, which divide to produce sperm; somatic cyst stem cells, which make a kind of cell that helps the sperm-producing cells out; and hub cells, which make signals that keep the other two kinds of cells going.
The hub cells are not stem cells; they have settled on their final form, incapable of dividing further or changing their functionor so everyone thought.
However, in a bid to figure out what happens when the somatic cyst stem cells are killed off, Matunis suggested that graduate student Phylis Hti figure out how to best do away with them, thinking the task would be straightforward.
Instead, she says, "it took a lot of heroic, patient combinations" of different genes working together to kill the somatic cyst cells, Matunis says.
"When we finally figured out a way to kill all of the somatic stem cells, we thought that the rest of the tissue would probably just empty out," she says. In 35 percent of testes, that's just what happened. But in the rest, the somatic stem cells grew back.
This was a surprise, Matunis says, and left a puzzle: Where were the new somatic stem cells coming from?
Read this article:
Surprise: Lost stem cells naturally replaced by non-stem cells, fly research suggests
- Exercise Helps Heart Disease Patients Live Longer [Last Updated On: November 8th, 2009] [Originally Added On: November 8th, 2009]
- If You Have A Heart Attack, Dial 911, Don't Drive To The ER [Last Updated On: November 8th, 2009] [Originally Added On: November 8th, 2009]
- Dried Plums, Tart Cherries, Grapes- What do they have in common? [Last Updated On: November 8th, 2009] [Originally Added On: November 8th, 2009]
- Vitamin D for Me! [Last Updated On: November 8th, 2009] [Originally Added On: November 8th, 2009]
- Bangkok Hospital Named Best Global Hospital [Last Updated On: November 8th, 2009] [Originally Added On: November 8th, 2009]
- 10 Years of Stem Cell Science? Where's the Beef? [Last Updated On: November 8th, 2009] [Originally Added On: November 8th, 2009]
- Women Underestimate Heart Disease Risks [Last Updated On: November 8th, 2009] [Originally Added On: November 8th, 2009]
- A Stem Cell First- New Organ Created and Transplanted Using Adult Stem Cells [Last Updated On: November 8th, 2009] [Originally Added On: November 8th, 2009]
- Stem Cells Injected Directly Into the Heart- Sounds Familiar [Last Updated On: November 8th, 2009] [Originally Added On: November 8th, 2009]
- Heart Disease and Depression Are Linked [Last Updated On: November 8th, 2009] [Originally Added On: November 8th, 2009]
- TheraVitae Wishes Everyone A Happy Thanksgiving [Last Updated On: November 8th, 2009] [Originally Added On: November 8th, 2009]
- VesCell Adult Stem Cells Helping Pulmonary Hypertension [Last Updated On: November 8th, 2009] [Originally Added On: November 8th, 2009]
- VesCell Adult Stem Cells Help Dilated Cardiomyopathy Patient [Last Updated On: November 8th, 2009] [Originally Added On: November 8th, 2009]
- Another Dilated Cardiomyopathy Patient Helped by VesCell Adult Stem Cells [Last Updated On: November 8th, 2009] [Originally Added On: November 8th, 2009]
- Clinical Data of VesCell Used On Heart Disease Patients [Last Updated On: November 8th, 2009] [Originally Added On: November 8th, 2009]
- Results of Patients Treated with Adult Stem Cells for Heart Disease [Last Updated On: November 8th, 2009] [Originally Added On: November 8th, 2009]
- Results of Doctor Using VesCell for Heart Disease Published in Medical Journal [Last Updated On: November 8th, 2009] [Originally Added On: November 8th, 2009]
- Stem Cells from VesCell Help Another Patient With Congestive Heart Failure [Last Updated On: November 8th, 2009] [Originally Added On: November 8th, 2009]
- VesCell Uses Adult Stem Cells Not Fetal Stem Cells [Last Updated On: November 8th, 2009] [Originally Added On: November 8th, 2009]
- Dilated Cardiomyopathy Continues Improving After Stem Cell Therapy [Last Updated On: November 8th, 2009] [Originally Added On: November 8th, 2009]
- American Doctors Form Group to Oppose FDA's Stance On Adult Stem Cells [Last Updated On: November 8th, 2009] [Originally Added On: November 8th, 2009]
- Adult Stem Cell Pioneer Passes Away [Last Updated On: November 8th, 2009] [Originally Added On: November 8th, 2009]
- Dilated Cardiomyopathy Patient Celebrates His 1 Year Stem Cell Treatment Anniversary [Last Updated On: November 8th, 2009] [Originally Added On: November 8th, 2009]
- Vescell Featured In Forbes Magazine! [Last Updated On: November 8th, 2009] [Originally Added On: November 8th, 2009]
- Adult Stem Cells Repair Damaged Heart Muscle [Last Updated On: November 8th, 2009] [Originally Added On: November 8th, 2009]
- No Scooter Needed for Schlueter- Heart Disease Patient Back in Gym After Stem Cell Treatment [Last Updated On: November 8th, 2009] [Originally Added On: November 8th, 2009]
- Stem cells provide second chance [Last Updated On: November 8th, 2009] [Originally Added On: November 8th, 2009]
- Adult Stem Cell Therapy Scientific Advisory Board [Last Updated On: November 8th, 2009] [Originally Added On: November 8th, 2009]
- Partner hospitals give Heart Disease treatment with Adult Stem Cell Therapy [Last Updated On: November 8th, 2009] [Originally Added On: November 8th, 2009]
- Stem Cell Treating Physicians for Heart Disease - Vescell by Theravitae [Last Updated On: November 8th, 2009] [Originally Added On: November 8th, 2009]
- Heart Disease Treatment FAQs - Adult Stem Cells Treats Heart Disease [Last Updated On: November 8th, 2009] [Originally Added On: November 8th, 2009]
- Checklist of 12 Must-Ask Questions for Overseas Treatment [Last Updated On: November 8th, 2009] [Originally Added On: November 8th, 2009]
- Health teaching for patients with heart disease | VesCell adult stem cell therapy [Last Updated On: November 8th, 2009] [Originally Added On: November 8th, 2009]
- Ethical Debates Adult Stem Cell Research | VesCell adult stem cells treatment [Last Updated On: November 8th, 2009] [Originally Added On: November 8th, 2009]
- Heart disease and health policy and nurse | VesCell adult stem cells treatment [Last Updated On: November 8th, 2009] [Originally Added On: November 8th, 2009]
- After Stent Symptoms | VesCell Adult Stem Cell Therapy [Last Updated On: November 8th, 2009] [Originally Added On: November 8th, 2009]
- What is adult stem cell research | VesCell Adult Stem Cell Therapy [Last Updated On: November 8th, 2009] [Originally Added On: November 8th, 2009]
- Alternative Medicine for Coronary Artery Disease | VesCell Adult Stem Cell Therapy [Last Updated On: November 8th, 2009] [Originally Added On: November 8th, 2009]
- Diabetic, Seven Heart Attack Patient Experiences on Adult Stem Cell Treatment [Last Updated On: November 8th, 2009] [Originally Added On: November 8th, 2009]
- Congestive Heart Failure and Life Expectancy | VesCell Adult Stem Cell Therapy [Last Updated On: November 8th, 2009] [Originally Added On: November 8th, 2009]
- Chest Pain After Angioplasty with Stent | VesCell adult stem cells treatment [Last Updated On: November 8th, 2009] [Originally Added On: November 8th, 2009]
- Use of Stem Cells for Heart Repair | VesCell Adult Stem Cell Therapy [Last Updated On: November 8th, 2009] [Originally Added On: November 8th, 2009]
- Women health heart attack [Last Updated On: November 8th, 2009] [Originally Added On: November 8th, 2009]
- Health Facts on the Heart | VesCell Adult Stem Cells Treatment [Last Updated On: November 8th, 2009] [Originally Added On: November 8th, 2009]
- The Process of Stem Cells | VesCell Adult Stem Cells Treatment [Last Updated On: November 8th, 2009] [Originally Added On: November 8th, 2009]
- Rest Pain Leg | VesCell adult stem cells for peripheral artery disease [Last Updated On: November 8th, 2009] [Originally Added On: November 8th, 2009]
- Health Supplements Heart Diabetes | VesCell Adult Stem Cells Treatment [Last Updated On: November 8th, 2009] [Originally Added On: November 8th, 2009]
- Heart Failure Epidemic | VesCell adult stem cells treatment [Last Updated On: November 8th, 2009] [Originally Added On: November 8th, 2009]
- Heart Muscle Health Aspects | VesCell adult stem cell therapy [Last Updated On: November 8th, 2009] [Originally Added On: November 8th, 2009]
- adult stem cells | VesCell adult stem cells treatment [Last Updated On: November 8th, 2009] [Originally Added On: November 8th, 2009]
- Updated article about adult stem cells therapy, VesCell, as featured in Forbes Magazine [Last Updated On: November 8th, 2009] [Originally Added On: November 8th, 2009]
- Forbes: Vescell Stem Cell Therapy Saves Heart Failure Patient [Last Updated On: November 8th, 2009] [Originally Added On: November 8th, 2009]
- Foetal Stem Cells Offer Hope for Stroke Victims [Last Updated On: November 8th, 2009] [Originally Added On: November 8th, 2009]
- Stem cells could spell end for diabetes jabs [Last Updated On: November 8th, 2009] [Originally Added On: November 8th, 2009]
- Full text answers about stem cell research [Last Updated On: November 8th, 2009] [Originally Added On: November 8th, 2009]
- Stem Cell Transplant from Umbilical Cord Blood Is The Only Hope for SCID Sufferer [Last Updated On: November 8th, 2009] [Originally Added On: November 8th, 2009]
- New Studies About Umbilical Cord Blood And Children With Diabetes [Last Updated On: November 8th, 2009] [Originally Added On: November 8th, 2009]
- Engineered Blood Vessels Function Like Native Tissu [Last Updated On: November 8th, 2009] [Originally Added On: November 8th, 2009]
- Umbilical Cord Blood Stem Cells Provide Hope for Life Threatening Diseases [Last Updated On: November 8th, 2009] [Originally Added On: November 8th, 2009]
- Gov. Schwarzenegger Signs SB962 to Create a System to Collect and Store Umbilical Cord Blood [Last Updated On: November 8th, 2009] [Originally Added On: November 8th, 2009]
- Baby Boy Treated for Cerebral Palsey with His Own Cord Blood Stem Cells [Last Updated On: November 8th, 2009] [Originally Added On: November 8th, 2009]
- Cord Blood May Preserve Insulin Production in Newly Diagnosed Children With Type 1 Diabetes [Last Updated On: November 8th, 2009] [Originally Added On: November 8th, 2009]
- A "Holy Grail" Of Healing, CBS Evening News [Last Updated On: November 8th, 2009] [Originally Added On: November 8th, 2009]
- After Receiving Unusual Stem Cell Transplant, Coppell Toddler Comes Home from Hospital [Last Updated On: November 8th, 2009] [Originally Added On: November 8th, 2009]
- Stem Cell Hope for Bone Fractures [Last Updated On: November 8th, 2009] [Originally Added On: November 8th, 2009]
- Cord Blood Stem Cells And Cardiovascular Disease [Last Updated On: November 8th, 2009] [Originally Added On: November 8th, 2009]
- Creating a Cord-Blood Lifeline [Last Updated On: November 8th, 2009] [Originally Added On: November 8th, 2009]
- Saving Cord Blood [Last Updated On: November 8th, 2009] [Originally Added On: November 8th, 2009]
- Stem Cell Implant to the Brain Helps Improve Parkinson's Symptoms: Presented at SIR [Last Updated On: November 8th, 2009] [Originally Added On: November 8th, 2009]
- Governor Rendell Signs Bill Into Law [Last Updated On: November 8th, 2009] [Originally Added On: November 8th, 2009]
- Curing Blood Diseases: How Cord Blood Saves Lives [Last Updated On: November 8th, 2009] [Originally Added On: November 8th, 2009]
- Cord Blood Registry Gains Momentum in First Quarter; Forecasts Strong Enrollment Growth in 2008 [Last Updated On: November 8th, 2009] [Originally Added On: November 8th, 2009]
- Study findings from University of Florida, Department of Pediatrics provide new insights into cord blood [Last Updated On: November 8th, 2009] [Originally Added On: November 8th, 2009]
- Cord Blood Can Be Used To Treat Adult Leukemia [Last Updated On: November 8th, 2009] [Originally Added On: November 8th, 2009]
- Umbilical cord a lifeline for 2 kids [Last Updated On: November 8th, 2009] [Originally Added On: November 8th, 2009]
- For Stem Cells, a Role on the Battlefield [Last Updated On: November 8th, 2009] [Originally Added On: November 8th, 2009]
- Cochlear Repair After Transplant Of Human Cord Blood Cells May Make Hearing Restoration Possible [Last Updated On: November 8th, 2009] [Originally Added On: November 8th, 2009]
- About Stem Cells [Last Updated On: November 8th, 2009] [Originally Added On: November 8th, 2009]
- Stem cells: Small wonders [Last Updated On: November 8th, 2009] [Originally Added On: November 8th, 2009]
- Stem Cell Therapy Lessens Damage Caused By Stroke [Last Updated On: November 8th, 2009] [Originally Added On: November 8th, 2009]