21.02.2014 - (idw) Ruprecht-Karls-Universitt Heidelberg

Heidelberg researchers have been delving into the basic regulatory mechanisms of stem cell differentiation. Using the Drosophila melanogaster fruit fly as a model organism, the team led by Prof. Dr. Ingrid Lohmann at Heidelberg University's Centre for Organismal Studies was able to show how a special developmental gene from the Hox family influences germline stem cells. These cells are responsible for sperm formation. The scientists found that impairment of Hox gene function resulted in prematurely aged sperms. Press Release Heidelberg, 21 February 2014

Fruit Fly Model Organism: How a Developmental Gene Influences Sperm Formation Heidelberg researchers study basic regulatory mechanisms of stem cell differentiation

Heidelberg researchers have been delving into the basic regulatory mechanisms of stem cell differentiation. Using the Drosophila melanogaster fruit fly as a model organism, the team led by Prof. Dr. Ingrid Lohmann at Heidelberg University's Centre for Organismal Studies was able to show how a special developmental gene from the Hox family influences germline stem cells. These cells are responsible for sperm formation. The scientists, working in the Maintenance and Differentiation of Stem Cells in Development and Disease Collaborative Research Centre (CRC 873), found that impairment of Hox gene function resulted in prematurely aged sperms.

As immature somatic cells, stem cells can mature into different types of cells, thus making them responsible for the development of all the tissues and organs in the body. They are also able to repair damaged adult cells. Advancements in medical research have shown that stem cells can be used to treat certain diseases. To fulfil the promise of stem cell therapy, it is important to discover the function of the respective stem cells and understand how they interact with their environment, that is, the surrounding cells and tissues, explains Prof. Lohmann, who heads the Developmental Biology research group at the Centre for Organismal Studies (COS).

This microenvironment, which stabilises and regulates stem cell activity, is called a stem cell niche. The Heidelberg research team investigated the niches in the testis of the fruit fly. The germline stem cells there produce daughter cells that develop into mature sperms. In our studies, we wanted to find out the nature, if any, of the relationship between germline stem cells and the gene Abd-B, states Prof. Lohmann, who further explains that Abd-B belongs to a family of developmental genes referred to as Hox genes. These Hox genes control the activity of a multitude of other genes that are responsible for the early development of an organism.

In CRC 873, funded by the German Research Foundation, medical and biological scientists investigate the basic regulatory mechanisms that control the self-renewal and differentiation of stem cells. Different model organisms like the fruit fly Drosophila melanogaster are used for their research, aimed at decoding the principles of stem cell control with the aim to also apply them to higher forms of life and eventually humans. The research results of Prof. Lohmann and her team were published in the journal Developmental Cell.

Original publication: F. Papagiannouli, L. Schardt, J. Grajcarek, N. Ha, I. Lohmann: The Hox Gene Abd-B Controls Stem Cell Niche Function in the Drosophila Testis. Developmental Cell, Vol 28. Iss 2, 189-202 (27 January 2014), doi: 10.1016/j.devcel.2013.12.016

Internet information: Research group of Ingrid Lohmann: http://www.cos.uni-heidelberg.de/index.php/i.lohmann?l=_e

Contact: Prof. Dr. Ingrid Lohmann Centre for Organismal Studies Phone: +49 6221 54-51312 ingrid.lohmann@bioquant.uni-heidelberg.de

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Fruit Fly Model Organism: How a Developmental Gene Influences Sperm Formation