A private Dragon spacecraft is headed back to Earth from the International Space Station Sunday (Oct. 28) to wrap up a landmark mission to the orbiting lab: the first commercial cargo flight for NASA.

The unmanned Dragon space capsule, built by the U.S. company SpaceX, was set free from the station by at 9:29 a.m. EDT (1329 GMT) as both spacecraft sailed 255 miles (410 kilometers) above Burma. The station's crew used the outpost's robotic arm to release the spacecraft.

"It was nice while she was on board. We tamed her [and] took her home," space station commander Sunita Williams of NASA radioed Mission Control in Houston as the Dragon capsule departed. "Literally and figuratively, there are pieces of us on that spacecraft going home to Earth."

The Dragon capsule is returning hundreds ofastronaut blood and urine samplesfrom the space station amid the 1,673 pounds (758 kilograms) of experiments and gear loaded on board. Some of those samples have been waiting for more than a year. NASA's final space shuttle mission landed in July 2011, leaving the agency without a way to return big cargo deliveries to Earth until Dragon's flight. [Photos: Dragon's 1st Space Cargo Delivery]

"Over the next few hours, Dragon will complete a series of engine burns that place the spacecraft on a final trajectory to re-enter the Earths atmosphere," SpaceX officials said in a mission update.

The spacecraft is expected to splash down in the Pacific Ocean, off the coast of Southern California, at 3:20 p.m. EDT (1920 GMT) and be retrieved by a SpaceX recovery crew so the cargo can be delivered to NASA. The mission is the first of 12 commercial resupply flights by SpaceX under a $1.6 billion deal with NASA.

The Hawthorne, Calif.-based SpaceX (short for Space Exploration Technologies) launched the Dragon capsule toward the space station on Oct. 7 using one of the company's own Falcon 9 rockets and a pad at Florida's Cape Canaveral Air Force Mission. The capsule was packed with 882 pounds (400 kg) of supplies to for the station, including 260 pounds (117 kg) of crew gear, 390 pounds (176 kg) of scientific equipment, 225 pounds (102 kg) of hardware and several pounds of other cargo, NASA officials said.

The cargo returning home on Dragon are 163 pounds (74 kg) of crew supplies, 866 pounds (392 kg) of scientific research and 518 pounds (235 kg) of vehicle hardware and other hardware, they added.

SpaceX is the first robotic spacecraft ever to be capable of returning cargo to Earth.

"It has been an historic mission," NASA spokesman Josh Byerly said during undocking commentary.

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Private SpaceX Capsule Leaves Space Station for Earth Return