Papers deriving from NASA support: 1 Smith SM, Zwart SR, Heer M. Human adaptation to space flight: The role of nutrition. Houston, TX: NASA Johnson Space Center. 2014; 151 p. NP-2014-10-018-JSC. http://www.nasa.gov/sites/default/files/human-adaptation-to-spaceflight-the-role-of-nutrition.pdf Note:ISS results. This report may be obtained online without charge. Journal Impact Factor:Not applicable to this publication Funding:No funding cited. S.M. Smith is at NASA Johnson Space Center. 2 Stabley JN, Prisby RD, Behnke BJ, Delp MD. Type 2 diabetes alters bone and marrow blood flow and vascular control mechanisms in the ZDF rat. J Endocrinol. 2015 Apr;225(1):47-58. http://www.ncbi.nlm.nih.gov/pubmed/25817711 PI:M.D. Delp Journal Impact Factor:3.586 Funding:"This study was supported by grants from the National Aeronautics and Space Administration (NNX12AL41G and NNX14AQ57G) and National Institutes of Health (AG-31317)." 3 S RC, Zeman KL, Bennett WD, Prisk GK, Darquenne C. Effect of posture on regional deposition of coarse particles in the healthy human lung. J Aerosol Med Pulm Drug Deliv. 2015 Mar 31. [Epub ahead of print] http://www.ncbi.nlm.nih.gov/pubmed/25826480 PI:G.K. Prisk; R.C. S, NSBRI Postdoctoral Fellowship Program Note:This article may be obtained online without charge. Journal Impact Factor:2.395 Funding:"The study was supported by National Space Biomedical Research Institute through NASA cooperative agreement NCC 9-58 (Grant HFP01604 and Postdoctoral Fellowship PF02103)." 4 LaVoy EC, Bollard CM, Hanley PJ, Blaney JW, O'Connor DP, Bosch JA, Simpson RJ. A single bout of dynamic exercise enhances the expansion of MAGE-A4 and PRAME-specific cytotoxic T-cells from healthy adults. Exerc Immunol Rev. 2015;21:144-53. http://www.ncbi.nlm.nih.gov/pubmed/25826370 PI:R.J. Simpson Note:This article may be obtained online without charge. Journal Impact Factor:9.929 Funding:"This work was partially supported by the National Aeronautics and Space Administration grant [NNX12AB48G] to R.J. Simpson, the University of Houston College of Liberal Arts and Social Sciences dissertation fellowship to E. LaVoy, and as part of a Leukemia and Lymphoma Society SCOR Project to C. Bollard." 5 Jeong Y, Carleton SM, Gentry BA, Yao X, Ferreira JA, Salamango DJ, Weis M, Oestreich AK, Williams AM, McCray MG, Eyre DR, Brown M, Wang Y, Phillips CL. Hindlimb skeletal muscle function and skeletal quality and strength in +/G610C mice with and without weight-bearing exercise. J Bone Miner Res. 2015 Mar 31. [Epub ahead of print] http://www.ncbi.nlm.nih.gov/pubmed/25829218 PI:S.M. Carleton, NSBRI Postdoctoral Fellowship Program Note:Mice were exposed to treadmill exercise regimen for the weight-bearing activity. Journal Impact Factor:6.589 Funding:"We would also like to thank the following funding sources: National Institutes of Health ARO55907 (YJJ, SMC, BAG, YY, DJS, AMW, ADKO, MGM,YW, CLP), T32 RR007004 (BAG), HD058834 (MB), AR037318 (DRE), HD070394 (DRE); National Space and Biomedical Research Institute NCC 9-58 (SMC); Leda J. Sears Trust Foundation (SMC, BAG, DJS, AMW, ADKO, MGM, CLP); Phi Zeta (BAG); University of Missouri Research Board (MB, CLP, JAF); Kansas City Area Life Sciences Institute (CLP, XY, YW ); University of Missouri Institute for Clinical and Translational Science (CLP, MB); University of Missouri Interdisciplinary Intercampus Research Program (CLP,YW,ADKO)." 6 Courtney A, Corrigan CF, Steffey D. Letter to the Editor regarding Bajaj D, et al., The resistance of cortical bone tissue to failure under cyclic loading is reduced with alendronate, Bone 2014;64:57-64. http://www.ncbi.nlm.nih.gov/pubmed/25797158 and Bajaj D, Geissler JR, Allen MR, Burr DB, Fritton JC. Response to Courtney et al. http://www.ncbi.nlm.nih.gov/pubmed/25813582 PI:D. Bajaj, NSBRI Postdoctoral Fellowship Program Note:These letters refer to the article: Bajaj D, Geissler JR, Allen MR, Burr DB, Fritton JC. The resistance of cortical bone tissue to failure under cyclic loading is reduced with alendronate. Bone. 2014 Jul;64:57-64.http://www.ncbi.nlm.nih.gov/pubmed/24704262, which appeared in SPACELINE Current Awareness List #610, August 8, 2014. Journal Impact Factor:3.823 Funding:"The National Institutes of Health (RR010601; AR007581;AR047838; AR062002; AR063351), the National Space Biomedical Research Institute (NASA contract NCC 9-58), and Merck (drug at no cost)." 7 Sasi SP, Park D, Muralidharan S, Wage J, Kiladjian A, Onufrak J, Enderling H, Yan X, Goukassian DA. Particle radiation-induced nontargeted effects in bone-marrow-derived endothelial progenitor cells. Stem Cells Int. 2015:496512. [Article in Press] http://www.hindawi.com/journals/sci/aa/496512/ PI:D.A. Goukassian Note:This article may be obtained online without charge. Journal Impact Factor:2.801 Funding:"This work was supported by the National Aeronautic and Space Administration (NASA) under Grant no. NNJ10ZSA001N and American Heart Association (AHA) Grant no. 14GRNT18860032 to David A. Goukassian. This work was also supported in part by Grants from AHA 10GRNT4710003 and NHLBI HL106098 to Xinhua Yan." 8 Armstrong PA, Wood SJ, Shimizu N, Kuster K, Perachio A, Makishima T. Preserved otolith organ function in caspase-3-deficient mice with impaired horizontal semicircular canal function. Exp Brain Res. 2015 Apr 1. [Epub ahead of print] http://www.ncbi.nlm.nih.gov/pubmed/25827332 PI:S.J. Wood Journal Impact Factor:2.168 Funding:The PI reports that the eye tracking software used was funded by NASA. ______________________________________________________ Other papers of interest: 1 Mandsager KT, Robertson D, Diedrich A. The function of the autonomic nervous system during spaceflight. Clin Auton Res. 2015 Mar 29. [Epub ahead of print] http://www.ncbi.nlm.nih.gov/pubmed/25820827 Note:STS-90 results. The paper reviews in-flight autonomic and hemodynamic data about sympathetic activation and vasorelaxation, highlighting results from NASAs NEUROLAB mission. 2 Putro WS, Lestair RE. The scoring quality of astronauts' sleeps using Fuzzy C-Means (FCM) during microgravity effect in the International Space Station (ISS). Sci J PPI-UKM. 2015;2(1):1-3. http://www.kemalapublisher.com/index.php/ppi-ukm/article/view/28/pdf_2 Note:ISS, STS-114 results. This article may be obtained online without charge. 3 Seedhouse E. Crew selection and medical care. In: Survival and Sacrifice in Mars Exploration. Springer Praxis Books: Springer International Publishing, 2015. p. 41-67. http://link.springer.com/chapter/10.1007%2F978-3-319-12448-3_3 4 Tajino J, Ito A, Nagai M, Zhang X, Yamaguchi S, Iijima H, Aoyama T, Kuroki H. Intermittent application of hypergravity by centrifugation attenuates disruption of rat gait induced by 2 weeks of simulated microgravity. Behav Brain Res. 2015 Mar 25. [Epub ahead of print] http://www.ncbi.nlm.nih.gov/pubmed/25819803 Note:Hindlimb unloading and centrifugation were used. 5 Brockhurst J, Cheleuitte-Nieves C, Buckmaster CL, Schatzberg AF, Lyons DM. Stress inoculation modeled in mice. Transl Psychiatry. 2015 Mar 31;5:e537. http://www.ncbi.nlm.nih.gov/pubmed/25826112 Note:Hindlimb unloading study. This article may be obtained online without charge. 6 Luo Z, Jiang L, Xu Y, Li H, Xu W, Wu S, Wang Y, Tang Z, Lv Y, Yang L. Mechano growth factor (MGF) and transforming growth factor (TGF)-3 functionalized silk scaffolds enhance articular hyaline cartilage regeneration in rabbit model. http://www.ncbi.nlm.nih.gov/pubmed/25818452 7 Olson AL, McNiece IK. Novel clinical uses for cord blood derived mesenchymal stromal cells. http://www.ncbi.nlm.nih.gov/pubmed/25819838 8 Shenkman BS, Lomonosova Iu N, Nemirovskaia TL. [Neuronal NO-synthase as the molecular guard of myofiber stability. NO-dependent signaling pathways in the active and unloaded muscle]. Usp Fiziol Nauk. 2014 Apr-Jun;45(2):37-48. Russian. Review. http://www.ncbi.nlm.nih.gov/pubmed/25707262 Note:The method of unloading is not specified. 9 Tagliaferri C, Wittrant Y, Davicco MJ, Walrand S, Coxam V. Muscle and bone, two interconnected tissues. Ageing Res Rev. 2015 May;21:55-70. Epub 2015Mar 21. Review. http://www.ncbi.nlm.nih.gov/pubmed/25804855 10 Quinlan E, Thompson EM, Matsiko A, O'Brien FJ, Lpez-Noriega A. Long-term controlled delivery of rhBMP-2 from collagen-hydroxyapatite scaffolds for superior bone tissue regeneration. J Control Release. 2015 Mar 25. [Epub ahead of print] http://www.ncbi.nlm.nih.gov/pubmed/25817394 11 Nawathe S, Yang H, Fields AJ, Bouxsein ML, Keaveny TM. Theoretical effects of fully ductile versus fully brittle behaviors of bone tissue on the strength of the human proximal femur and vertebral body. J Biomech. 2015 Mar 12. [Epub ahead of print] http://www.ncbi.nlm.nih.gov/pubmed/25828400 12 Miller GJ, Gerstenfeld LC, Morgan EF. Mechanical microenvironments and protein expression associated with formation of different skeletal tissues during bone healing. Biomech Model Mechanobiol. 2015 Mar 31. [Epub ahead of print] http://www.ncbi.nlm.nih.gov/pubmed/25822264 13 Harrison J. Overview of ICRP Committee 2 'Doses from radiation exposure.' Ann ICRP. 2015 Feb 12. [Epub ahead of print] http://www.ncbi.nlm.nih.gov/pubmed/25816256 14 Kim CS, Seong KM, Lee BS, Lee IK, Yang KH, Kim JY, Nam SY. Chronic low-dose -irradiation ofDrosophila melanogasterlarvae induces gene expression changes and enhances locomotive behavior. J Radiat Res. 2015 Mar 19. [Epub ahead of print] http://www.ncbi.nlm.nih.gov/pubmed/25792464 Note:This article may be obtained online without charge. 15 Liu Q, Zhou R, Zhao X, Oei TPS. Effects of prolonged head-down bed rest on working memory. Neuropsychiatr Dis Treat. 2015 Mar 25;11:835-42. http://www.dovepress.com/effects-of-prolonged-head-down-bed-rest-on-working-memory-peer-reviewed-fulltext-article-NDT Note:Bed rest study. This article may be obtained online without charge. 16 Lasota PA, Shah JA. Analyzing the effects of human-aware motion planning on close-proximity human-robot collaboration. Hum Factors. 2015 Feb;57(1):21-33. http://www.ncbi.nlm.nih.gov/pubmed/25790568 17 Shao Y, Sang J, Fu J. On human pluripotent stem cell control: The rise of 3D bioengineering and mechanobiology. http://www.ncbi.nlm.nih.gov/pubmed/25818411 18 Coon BG, Baeyens N, Han J, Budatha M, Ross TD, Fang JS, Yun S, Thomas JL, Schwartz MA. Intramembrane binding of VE-cadherin to VEGFR2 and VEGFR3 assembles the endothelial mechanosensory complex. J Cell Biol. 2015 Mar 30;208(7):975-86. Epub 2014 Mar 23. http://www.ncbi.nlm.nih.gov/pubmed/25800053 19 Bernardeschi I, Greco F, Ciofani G, Marino A, Mattoli V, Mazzolai B, Beccai L. A soft, stretchable and conductive biointerface for cell mechanobiology. Biomed Microdevices. 2015 Apr;17(2):46. http://www.ncbi.nlm.nih.gov/pubmed/25797705

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NASA Spaceline Current Awareness List #643 - 10 April 2015