These chronological lists include all crewed spaceflights that reached an altitude of at least 100km (the FAIdefinition of spaceflight, see Krmn line), or were launched with that intention but failed. The USA has adopted a slightly different definition of spaceflight, requiring an altitude of only 50 miles (80km). During the 1960s, 13 flights of the US X-15 rocket planemet the US criteria, but only two met the FAI's. These lists include only the latter two flights; see the list of highest X-15 flightsfor all 13. As of the launch of Soyuz MS-08 on March 21st 2018, there have been 319 crewed spaceflights that reached 100km or more in altitude (321 attempted crewed flights with two failed attempts), 8 of which were sub-orbital spaceflights.

To date, there have been four fatal missions in which 18 astronauts died.

*Includes the two failed launches of STS-51-L and Soyuz T-10-1.

The Salyut series, Skylab, Mir, ISS, and Tiangong series space stations, with which various of these flights docked in orbit, are not listed separately here. See the detailed lists (links above) for information.

Missions which were intended to reach space but which failed to do are listed in italics, and fatal missions are marked with asterisk.

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List of human spaceflights - Wikipedia