Resveratrol is one of my favorite supplements. I use this for increasing the amplitude of my circadian rhythm, increasing energy production and for anti-inflammatory effects. Resveratrol makes me feel like I have excess energy.

Resveratrolcame to scientific attention during the mid-1990s. Since then, it has been toutedby manufacturers and examined by scientific researchers as an antioxidant (R), an anti-cancer agent, and a phytoestrogen. Commonly calledThe French Paradox in a bottle.

Resveratrol is a beneficial compound found in red wine that is associated with life extension and some of the health benefits in wine. It is produced in grapes as a defense against toxins, and is abundant in the skins.

Resveratrol is effective in inhibiting or reversing some of theeffects of aging like osteoporosis, sarcopenia, mental processes decline, etc(R).

Resveratrol appears to reduce seizures and hippocampal neurotoxicity in animal models (by suppressing kainate receptor signaling) (R).

Resveratrol acts on glial cells which are involved in neurotransmission and it has been noted to increase glutamate uptake into glial cells (R).

Resveratrol induces the antioxidant enzyme, heme-oxygenase 1, which is linked to neuroprotection (R).

Lifelong supplementation of resveratrol may increase lifespan and delay bio markers of Alzheimers (by preventing beta-amyloid and tau protein aggregation) (R).

Resveratrolincreases IGF-1 in the memory center (hippocampus) of the brain (R), which improves memory.

Resveratrol has been demonstrated to reduce blood pressure in people at risk for heart disease (R).

Resveratrol has been investigated for its contribution to heart health after a meta-analysis first found a significant risk reduction associated with 1-2 glasses (150-300 ml) of wine daily (R).

Resveratrol helps heart health by inhibiting NADPH (in vitro) and by inducing eNOS (R).

Resveratrol is anti-atherogenic (reduces the formation of plaque in arteries) (R).

Resveratrol also attenuates Trimethylamine-N-Oxide (TMAO)-Induced atherosclerosis by regulating TMAO synthesis and bile acid metabolism via changingthe gut microbiota (R).

Resveratrol has been shown to increase insulin sensitivity in obese people (150 mg daily) (R) and therefore helps with glucose metabolism.

Resveratrol can be useful in preventing and treating diabetes (R).

Resveratrol can cause the death of fat cells (R).

Resveratrol can benefit weight loss by inhibiting fatty acid synthase, lipoprotein lipase and hormone-sensitive lipase (R).

Resveratrol enhances mitochondrial function (through SIRT1 activation of PGC 1alpha) (R), which can improve metabolism.

Resveratrol increases bone cells by redirecting stem cells from becoming fat cells (R), which may increase bone health.

Resveratrol synergizes with Vitamin D for bone health (R).

Resveratrol protects against liver cancer (in vitro) (R) and is being investigated for usage in liver metastasis prevention in humans (R).

It has shown promise on skin cancers when used on the body surface of mice (R).

Resveratrol is effective against esophageal cancer when ingested orally in rats (R).

Resveratrol can be used to prevent and treat breast cancer (R).

Resveratrols anti-cancer effects come, in part, from its regulation of the topoisomerase II enzyme (R).

Resveratrol inhibits the growth of Leukemia cells (R).

In animal models, resveratrol can help conditions in which bile flow is obstructed by inhibiting MMP-2 and MMP-9. (R)

Resveratrol prevents and improves Nonalcoholic Fatty liver disease (NAFLD) (R).

It prevents liver damage in sepsis (R).

Resveratrol has positive effect on muscle growth(R).

Resveratrol supplementation enhances aerobic performance (R).

Resveratrol has a good anti-radiation effect (at 100 and 300 mg/Kg concentration) (R).

Resveratrol has a protective effect on noise-induced hearing loss (R).

Resveratrol also prevents toxicity of ear caused by cisplatin (a chemotherapeutic agent used to treat cancer) (R).

High doses of Resveratrol can increase Testosterone.

Resveratrol could act as an Estrogen agonist or Estrogen antagonist (R).

Consumption of resveratrol may be connected to autophagy induction (R).

Resveratrol gel showed positive results in treatment of Acne in humans (R)

Resveratrol inhibited herpes virus infection of ducks, geese etc. (R).

Resveratrol inhibited the Influenza virus (R).

Resveratrol has shown to inhibit the activity of Epstein-Barr virus (R).

Resveratrol has shown to inhibit Herpes simplex virus-1 and Herpes simplex virus-2 (HSV-1 and HSV-2) (R).

Resveratrol has shown to inhibit the Respiratory Syncytial virus in mice (R).

Resveratrol showed activity against Human Immunodeficiency virus-1 and was synergistic with decitabine (R).

Resveratrol also inhibited Varicella zoster and Enterovirus 71 (EV 71) (R).

Resveratrol inhibited African swine fever virus in-vitro (R).

Resveratrol with quercetin showed an inhibitory effect on Human meta pneumonia (hMPV) virus infection (R).

Resveratrol inhibited Human rhinovirus (HRV) and Cytomegalovirus (R).

Resveratrol showed anti-fungal activity against Candida albicans (R).

Resveratrol showed antibacterial activity against MRSA in humans (Methicillin Resistant Staphylococcus aureus) (R).

Resveratrol showed antibacterial activity against E.Coli (R).

Resveratrol inhibited the growth of Propionibacterium acnes,the bacteria which causes acne(R).

Resveratrol had an antibacterial effect on Haemophilus ducreyi (R).

Resveratrol inhibited Arcobacter butzleri and Arcobacter cryaerophilusa (R).

Resveratrol and SIRT1 make you more sensitive to vitamin D it potentiates the vitamin D receptor (VDR) (R, R2).

Resveratrolpotentiates VDR by (1) potentiating 1,25D binding to VDR; (2) activating RXR; (3) stimulating SIRT1(R).

Resveratrol decreases MAOA (strong) (R), which should help with depression.

Resveratrol prevents a high-fat diet decrease in Tregs (R).

Resveratrol inhibits mTOR in a unique way (R), which should benefit autoimmunity, cancer, and longevity.

Resveratrol activates AMPK (R).

You must take resveratrol first thing in the morning.

I use resveratrol to improve circadian rhythm amplitude. Increasing your circadian amplitude results inincreasedenergy in the day time and increased tirednessat night.

When I take resveratrol first thing in the morning, I feel much more energetic that day.

Resveratrol increases circadian amplitude by increasing SIRT1. I take it with Niagen NAD+.

Resveratrol, when taken along with few compounds, shows enhanced functioning.

Since resveratrol increases SIRT1, taking with Niagen NAD+ will make it work more effectively, by increasing SIRT1 activity.

Resveratrol along with the phytonutrient Genistein roughly showed double their individual activity on fat metabolism (R).

Quercetin was also synergistic with Resveratrol in the protection of blood vessels (R).

Resveratrol, Genistein and Quercetin together showed further synergism, and low dosing of these three can provide cumulatively similar benefits at cheaper costs (R).

Resveratrols anti-cancer effects can be increased with co-ingestion of Indole-3-carbinol (R).

Resveratrol along withCurcumin has proven to be effective in an animal model of lung cancer (R).

Synergism between D-Glucaro-1,4-Lactone and Resveratrol has also been noted in preventing skin cancer occurrence when ingested orally (R).

Both Melatonin and Resveratrol also exert neuroprotection and anti-oxidative properties, which are enhanced when together (R).

In the presence of resveratrol, grape seed extract has significantly more drug activity in destroying cancer cells via the p53 pathway (R).

This synergism has also been noted in regards to preventing skin cancer in mice (R).

The combination of resveratrol and quercetin, a flavonoid from certain foods, can also have more health benefits. For example, they combine their effects together to inhibit colon cancer and increase cancer cell death (apoptosis) in human cell culture [R].

In rats, this combination also significantly reduced fat tissue. In contrast, resveratrol or quercetin alone did not have any effect on the fat tissue. The combination of resveratrol and quercetin is synergistic [R].

Most supplements contain 50-500 mg of Resveratrol, but to get the dose equivalent in some animal studies people will have to consume 2 gm or more per day.

Many leading Resveratrol researchers believe that 5 mg of Resveratrol per Kg of body weight is the suitable amount for human intake. So for a 150 pound person (68 kg),this translates to 340mg of resveratrol per day (R).

I personally take about 500 mg of resveratrol (Im about 70 kg), which equates to roughly 3 teaspoons or 15 gm of the liposomal form.

Some studies showed that taking 150 mg of Resveratrol once daily for 30 days significantly lowered sleeping and resting metabolic rate (R).

The delivery of resveratrol might influence its effectiveness on health.

In mice, scientists tested resveratrols effects when supplemented in a normal diet, a high-fat diet, and through a pump. They found that a high fat diet helped increase antioxidant levels and mitochondrial activity in the brain [R].

Meanwhile, a normal diet did not show these same effects. A high fat diet can help deliver resveratrol to different parts of the body and increase its effectiveness [R].

Resveratrol cant be found in meaningful concentrations in food. However, here are some foods which have resveratrol:

Resveratrol is found in the skin of red grapes.The richest source of resveratrol comes from the red grapes of Spain (1.89 mg per fiveounce glass) (R).

One cup of Boiled Peanuts contains 1.28 mg of Resveratrol.

Peanut Butter contains up to 13 mg per cup of Resveratrol.

A study revealed that 500 mg tablets are well tolerated by healthy men and women (R).

In humans, up to 5 gm have been taken with no side effects outside of some nausea (R) and some intestinal upset (R).

Resveratrol binds to iron, so if youre anemic that could be a problem.

If taking medications that change the liver such as Mevacor, Nizoral, Sporanox, Allegra and Halcoin avoid this supplement.

HIV protease inhibitors and immunosuppressants.

Excerpt from:

Top 16 Scientific Health Benefits of Resveratrol (With ...