Bladder cancer (BC) is a leading cause of death among urothelial malignancies that more commonly affect male population. Poor prognosis and resistance to chemotherapy are the two most important characteristics of this disease. PI3K/Akt/mTOR signaling pathway has been considered pivotal in the regulation of proliferation, migration, invasiveness, and metastasis. Deregulation of PI3K/Akt/mTOR signaling has been found in 40% of bladder cancers. Several microRNAs (miRNAs) have been reported to interact with the PI3K/Akt/mTOR signaling pathway with a different possible role in proliferation and apoptosis in bladder cancer. Thus, miRNAs can be used as potential biomarkers for BC. Natural compounds have been in the spotlight for the past decade due to their effective anti-proliferative capabilities. However, little is known of its possible effects in bladder cancer. The aim of this review is to discuss the interplay between PI3K/Akt/mTOR, miRNAs, and natural compounds and emphasize the importance of miRNAs as biomarkers and resveratrol, curcumin and paclitaxel as a possible therapeutic approach against bladder cancer.

Cancer cell international. 2020 Nov 23*** epublish ***

Khushbukhat Khan, Cristina Quispe, Zeeshan Javed, Muhammad Javed Iqbal, Haleema Sadia, Shahid Raza, Asma Irshad, Bahare Salehi, eljko Reiner, Javad Sharifi-Rad

Atta-Ur-Rahman School of Applied Biosciences (ASAB), National University of Sciences and Technology (NUST), Sector H-12, Islamabad, 44000, Pakistan., Facultad de Ciencias de La Salud, Universidad Arturo Prat, Avda. Arturo Prat 2120, 1110939, Iquique, Chile., Lahore Garrison University, Main Campus, Sector C, Phase VI, DHA Lahore Pakistan, Lahore, Pakistan., Department of Biotechnology, Faculty of Sciences, University of Sialkot, Punjab, Pakistan., Department of Biotechnology, BUITMS, Quetta, Pakistan., Department of Life Sciences, University of Management Sciences, Lahore, Pakistan., Medical Ethics and Law Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. ., Department of Internal Medicine, School of Medicine, University Hospital Centre Zagreb, University of Zagreb, Zagreb, Croatia., Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. .

PubMed http://www.ncbi.nlm.nih.gov/pubmed/33292283

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Resveratrol, curcumin, paclitaxel and miRNAs mediated regulation of PI3K/Akt/mTOR pathway: go four better t... - UroToday