Blanca Olivia Murillo Ortiz,1 Alma Rosa Fuentes Preciado,2 Joel Ramrez Emiliano,2 Sandra Martnez Garza,1 Edna Ramos Rodrguez,3 Luz Anglica de Alba Macas2

1Clinical Epidemiology Research Unit, UMAE No. 1 Bajio, Mexican Institute Social Security, Len, Guanajuato, Mexico; 2Department of Medical Sciences, University of Guanajuato, Len, Guanajuato, Mexico; 3Regional General Hospital No. 58, Mexican Institute Social Security, Len, Guanajuato, Mexico

Correspondence: Blanca Olivia Murillo OrtizUnidad de Investigacin en Epidemiologa Clnica, Unidad Mdica de Alta Especialidad No. 1 Bajo, Instituto Mexicano del Seguro Social, Boulevard Lpez Mateos e Insurgentes s/n, Colonia Los Parasos, Len, Guanajuato, MxicoTel/Fax +52 4777183039Email bomo907@hotmail.com

Introduction: Malnutrition is common in haemodialysis patients and closely related to morbidity and mortality. We evaluated the effect of twelve weeks of supplementation with resveratrol and curcumin on recovery of bone and muscle mass and protein oxidation, lipid peroxidation on patients with chronic kidney disease and iron overload undergoing hemodialysis, we performed a randomized, double-blind, placebo-controlled trial.Methods: We included a total of 40 patients, were randomly assigned to two groups, 20 to the group with antioxidant supplementation (Resveratrol + Curcumin) (Group A), treated with a daily oral dose of 500 mg of Resveratrol and 500 mg of Curcumin, and 20 to the control group treated with placebo (Group B).Results: Significant differences were found in the body composition of the patients between both groups. There was a significant difference in Body Mass Index (BMI) values (p = 0.002), fat percentage (p = 0.007), muscle mass (p = 0.01) bone mass (p = 0.01), as well as in the score of the subjective global evaluation (p = 0.03). Also differences were found between the basal and final serum levels of Triglycerides (TG) (p = 0.01), VLDL (p = 0.003). A significant decrease in the levels of serum ferritin (2003.69 518.73 vs 1795.65 519.00 ng/mL; p = 0.04). Nor were significant differences observed between the baseline and the final Thiobarbituric Acid Reactive Substances (TBARS) values (70.45 69.21 vs 50.19 32.62, p = 0.24). The same results was obtained for carbonyl values (2.67 0.75 vs 2.50 0.85; p = 0.50).Discussion: The present study is the first assay on patients with chronic kidney disease and iron overload that demonstrates the beneficial effects of combined supplementation with Curcumin and Resveratrol on muscle and bone mass. There was a significant decrease in circulating levels of ferritin, to finding that remarkably novel.

Keywords: curcumin, resveratrol, chronic kidney disease, recovery of bone and muscle mass

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