Human physiology is the science of the mechanical, physical, bioelectrical, and biochemical functions of humans in good health, their organs, and the cells of which they are composed. Physiology focuses principally at the level of organs and systems. Most aspects of human physiology are closely homologous to corresponding aspects of animal physiology, and animal experimentation has provided much of the foundation of physiological knowledge. Anatomy and physiology are closely related fields of study: anatomy, the study of form, and physiology, the study of function, are intrinsically related and are studied in tandem as part of a medical curriculum.

The study of human physiology dates back to at least 420 B.C. and the time of Hippocrates, the father of medicine.[1] The critical thinking of Aristotle and his emphasis on the relationship between structure and function marked the beginning of physiology in Ancient Greece, while Claudius Galenus (c. 126-199 A.D.), known as Galen, was the first to use experiments to probe the function of the body. Galen was the founder of experimental physiology.[2] The medical world moved on from Galenism only with the appearance of Andreas Vesalius and William Harvey.[3]

During the Middle Ages, the ancient Greek and Indian medical traditions were further developed by Muslim physicians. Notable work in this period was done by Avicenna (980-1037), author of the The Canon of Medicine, and Ibn al-Nafis (12131288), among others.[citation needed]

Following from the Middle Ages, the Renaissance brought an increase of physiological research in the Western world that triggered the modern study of anatomy and physiology. Andreas Vesalius was an author of one of the most influential books on human anatomy, De humani corporis fabrica.[4] Vesalius is often referred to as the founder of modern human anatomy.[5]Anatomist William Harvey described the circulatory system in the 17th century,[6] demonstrating the fruitful combination of close observations and careful experiments to learn about the functions of the body, which was fundamental to the development of experimental physiology. Herman Boerhaave is sometimes referred to as a father of physiology due to his exemplary teaching in Leiden and textbook Institutiones medicae (1708).[citation needed]

In the 18th century, important works in this field were by Pierre Cabanis, a French doctor and physiologist.[citation needed]

In the 19th century, physiological knowledge began to accumulate at a rapid rate, in particular with the 1838 appearance of the Cell theory of Matthias Schleiden and Theodor Schwann. It radically stated that organisms are made up of units called cells. Claude Bernard's (18131878) further discoveries ultimately led to his concept of milieu interieur (internal environment), which would later be taken up and championed as "homeostasis" by American physiologist Walter Cannon (18711945).[clarification needed]

In the 20th century, biologists also became interested in how organisms other than human beings function, eventually spawning the fields of comparative physiology and ecophysiology.[7] Major figures in these fields include Knut Schmidt-Nielsen and George Bartholomew. Most recently, evolutionary physiology has become a distinct subdiscipline.[8]

The biological basis of the study of physiology, integration refers to the overlap of many functions of the systems of the human body, as well as its accompanied form. It is achieved through communication that occurs in a variety of ways, both electrical and chemical.

In terms of the human body, the endocrine and nervous systems play major roles in the reception and transmission of signals that integrate function. Homeostasis is a major aspect with regard to the interactions within an organism, humans included.

The term "homeostasis" is the property of a system that regulates its internal environment and tends to maintain a stable, relatively constant condition of properties such as temperature or pH. It can be either an open or closed system. In simple terms, it is a process in which the body's internal environment is kept stable. This is required for the body to function sufficiently. The Homeostatic process is essential for the survival of each cell, tissue, and body system. Maintaining a stable internal environment requires constant monitoring, mostly by the brain and nervous system. The brain receives information from the body and responds appropriately through the release of various substances like neurotransmitters, catecholamines, and hormones. Individual organ physiology furthermore facilitates the maintenance of homeostasis of the whole body e.g. Blood pressure regulation: the release of renin by the kidneys allow blood pressure to be stabilized (Renin, Angiotensinogen, Aldosterone System), though the brain helps regulate blood pressure by the Pituitary releasing Anti-Diuretic Hormone (ADH). Thus, homeostasis is maintained within the body as a whole, dependent upon its parts.

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