1. Physiology
  2. Angelika Amon (MIT and HHMI)

Angelika Amon (MIT and HHMI) Part 2: Effects of Aneuploidy on Cell Physiology – Video

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Video Link: https://www.youtube.com/watch?v=J45C2LbaGqs



Angelika Amon (MIT and HHMI) Part 2: Effects of Aneuploidy on Cell Physiology
Consequences of Aneuploidy Overview Amon begins her talk by explaining what aneuploidy is and how it arises. She explains that autosomal aneuploidy is usually devastating to an organism, while aneuploidy at a cellular level may result in the unrestricted growth seen in cancer. In Part 2, Amon provides more details about the impact of aneuploidy on individual cells. Using budding yeast and mouse lines engineered to have specific aneuploidies, Amon #39;s lab was able to show that aneuploid cells show gene specific effects, as well as a higher overall level of cellular stress. Part 3 focuses on the role of aneuploidy in disease, specifically in cancer. Amon discusses how identifying enhancers and suppressors of the aneuploid condition can shed light on the effects of aneuploidy in cancer and can lead to the development of novel cancer therapeutics. Biography Angelika Amon received both her BS and Ph.D. degrees from the University of Vienna. She was a post-doctoral fellow at the Whitehead Institute and was subsequently named a Whitehead Fellow. In 1999, she joined the Massachusetts Institute of Technology where she is currently Professor of biology and Kathleen and Curtis Marble Professor in cancer research at the Koch Institute. Amon is also an Investigator of the Howard Hughes Medical Institute. Amon #39;s lab uses budding yeast as a model to understand the regulatory mechanisms that ensure the correct segregation of chromosomes during mitosis and meiosis. Her lab also investigates ...

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Angelika Amon (MIT and HHMI) Part 2: Effects of Aneuploidy on Cell Physiology - Video

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  1. Physiology
  2. Angelika Amon (MIT and HHMI)