Dedication

List of Contributors

Preface

Chapter 1. Principles of Pharmacogenomics: Pharmacokinetic, Pharmacodynamic, and Clinical Implications

Objectives

Introduction

Cytochrome P-450 Enzymes

Non-CYP-450 Drug Metabolizing Enzymes

Polymorphisms in Drug Transporter Genes

Drug Target Genes

Conclusion

Questions for Discussion

References

Chapter 2. Translating Pharmacogenomic Research to Therapeutic Potentials

Objectives

Introduction

Implementation of Biomarkers in Clinical Practice

Incorporating Pharmacogenomics intoDrugDevelopment

Conclusion

Questions for Discussion

References

Chapter 3. Governmental and Academic Effortsto Advance the Field ofPharmacogenomics

Objectives

Introduction

The Role of the National Institutes of Health

The Role of the Food and Drug Administration and OtherInternational Government Agencies

Activities of Non-U.S. Agencies

Conclusion

Questions for Discussion

References

Chapter 4. Pharmacogenomics in Cancer Therapeutics

Objectives

Introduction

Role of Oncology Biomarkers

Concepts in Targeted Cancer Therapy

Oncology in the Postgenomic Era

Challenges in Drug Development and Cancer Trials

Seeking Pharmacogenomic Value

Questions for Discussion

References

Chapter 4A. A Look to the Future: CancerEpigenetics

Learning Objectives

Introduction

Histone Modification

DNA Methylation

Noncoding RNA (ncRNA)

Conclusion

Questions for Discussion

References

Chapter 5. Pharmacogenetics in Cardiovascular Diseases

Objectives

Introduction

Pharmacogenomics of Antiplatelet Agents

Warfarin Pharmacogenomics

Other Genetic Contributions to Warfarin Dose Variability and Response

Trials and Tribulations of Pharmacogenomics of Agents Used to Treat Dyslipidemia

Pharmacogenomic Potential in Heart Failure

Genetic Influences of Drug-Induced Arrhythmia

Conclusion

Discussion Points

Discussion Questions

References

Chapter 5A. A Look to the Future: Cardiovascular Pharmacoepigenetics

Learning objectives

Introduction

Opportunities

Challenges

Conclusion

Questions for Discussion

References

Chapter 6. Pharmacogenomics in Psychiatric Disorders

Objectives

Introduction

Polymorphisms in Proteins that Affect Drug Concentrations

Polymorphisms in Proteins that Mediate Drug Response

Application of Pharmacogenomics in Psychiatry

Conclusion

Questions for Discussion

References

Chapter 6A. A Look to the Future: Epigenetics in Psychiatric Disorders and Treatment

Objectives

Nature and Nurture Both Contribute to the Etiologies of Psychiatric Disorders

Epigenetic Processes Are Likely to Contribute to the Biochemical Basis of Nurture

Epigenetic Dysfunction Has Been Linked to Psychiatric and Neurological Disorders

Epigenetic Processes May Be Critical to Treatment Response in Psychiatric Disorders

Epigenetic Variation of Genes Regulating Pharmacokinetic Processes Is Likely to Influence Treatment Response

Epigenetic Modifications of Drug Transporters

Epigenetics and Adverse Drug Reactions

Limitations of Epigenetic Biomarkers in Psychiatry

Conclusion

Questions for Discussion

References

Chapter 7. The Role of Pharmacogenomics in Diabetes, HIV Infection, and Pain Management

Objectives

Introduction

Diabetes Overview

Type 2 Diabetes Pharmacogenomics

Challenges and Opportunities of Pharmacogenomics in Diabetes

Pharmacogenomics and HIV

Pharmacogenomics and Pain Control

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Pharmacogenomics - 1st Edition - Elsevier