1. Parkinson's disease
  2. Effect of G2019S mutation on

Effect of G2019S mutation on LRRK2 – Video

Posted on by


Video Link: https://www.youtube.com/watch?v=d0S7dPfxe_U



Effect of G2019S mutation on LRRK2
This video demonstrates molecular dynamics simulation of the Parkinson #39;s disease linked mutation G2019S on LRRK2 kinase. A typical kinase undergoes a duty cycle switching between "on" (DFG-in) and "off" (DFG-out) states regulating its own activity. The G2019S mutant however does not and stays in a perpetual "on" state that eventually eventually leads to Parkinson #39;s disease.

By: Soumya Ray

More:
Effect of G2019S mutation on LRRK2 - Video

Related Posts

Comments are closed.


  1. Parkinson's disease
  2. Effect of G2019S mutation on