Papers deriving from NASA support: 1 Martinez-Morentin L, Martinez L, Piloto S, Yang H, Schon EA, Garesse R, Bodmer R, Ocorr K, Cervera M, Arredondo JJ. Cardiac deficiency of single cytochrome oxidase assembly factor scox induces p53 dependent apoptosis in aDrosophilacardiomyopathy model. Hum Mol Genet. 2015 Mar 19. [Epub ahead of print] http://www.ncbi.nlm.nih.gov/pubmed/25792727 PI:R. Bodmer Journal Impact Factor:6.677 Funding:This work was supported by grants Direccion General de Investigacion Ciencia y Tecnologia [BFU2007-61711BMC and BFU2010-19551 to MC]; American Heart Association [Grant in Aid #14GRNT20490239 to KO]; NASA [NRA NNH12ZTT001N to KO and NRA NNH12ZTT001N to RB]; National Institute of Health [R01 HL054732, P01 AG033461, P01 HL098053 to RB]; Centre for Biomedical Research on Rare Diseases, Instituto de Salud Carlos III [PI10/0703 and PI13/00556 to RG]; Comunidad de Madrid [S2010/BMD-2402 to RG]; Muscular Dystrophy Association to EAS; the U.S. Department of Defence [W911F-12-1-0159 to EAS]; and J. Willard and Alice S. Marriott Foundation to EAS. 2 Blue RS, Reyes DP, Castleberry TL, Vanderploeg JM. Centrifuge-simulated suborbital spaceflight in subjects with cardiac implanted devices. Aerosp Med Hum Perform. 2015 Apr;86(4):410-3. http://www.ingentaconnect.com/content/asma/amhp/2015/00000086/00000004/art00014 PI:J.M. Vanderploeg Note:Centrifugation was used. Journal Impact Factor:0.782 Funding:The authors acknowledge the additional support from the National Space Biomedical Research Institute (NSBRI) through NASA NCC 9-58. 3 Levin DR, Blue RS, Castleberry TL, Vanderploeg JM. Tolerance of centrifuge-simulated suborbital spaceflight in subjects with implanted insulin pumps. Aerosp Med Hum Perform. 2015 Apr;86(4):407-9. http://www.ingentaconnect.com/content/asma/amhp/2015/00000086/00000004/art00013 PI:J.M. Vanderploeg Note:Centrifugation was used. Journal Impact Factor:0.782 Funding:The authors acknowledge the additional support from the National Space Biomedical Research Institute (NSBRI) through NASA NCC 9-58. 4 Mukherjee B, Tomimatsu N, Burma S. Immunofluorescence-based methods to monitor DNA end resection. Methods Mol Biol. 2015;1292:67-75. http://www.ncbi.nlm.nih.gov/pubmed/25804748 PI:S. Burma Journal Impact Factor:1.29 Funding:SB is supported by grants from the National Institutes of Health (RO1 CA149461) and the National Aeronautics and Space Administration (NNX13AI13G). 5 Popova Y, Boyle R. Neural response in vestibular organ ofHelix aspersato centrifugation and re-adaptation to normal gravity. J Comp Physiol A Neuroethol Sens Neural Behav Physiol. 2015 Mar 24. [Epub ahead of print] http://www.ncbi.nlm.nih.gov/pubmed/25801308 PI:R. Boyle Note:Centrifugation was used. Journal Impact Factor:1.634 Funding:This work was funded by NASA Postdoctoral Program administered by Oak Ridge Associated Universities (to YP) and in part by NASA grant (11_Omni_2-0002) and the NASA Human Research Program (to RB). 6 Li M, Holmes V, Ni H, Sanzari JK, Romero-Weaver AL, Lin L, Carabe-Fernandez A, Diffenderfer ES, Kennedy AR, Weissman D. Broad-spectrum antibiotic or G-CSF as potential countermeasures for impaired control of bacterial infection associated with an SPE exposure during spaceflight. PLoS One. 2015 Mar 20;10(3):e0120126. http://www.ncbi.nlm.nih.gov/pubmed/25793272 PI:A.R. Kennedy/Center of Acute Radiation Research Note:Hindlimb unloading study.This article may be obtained online without charge. Journal Impact Factor:3.534 Funding:This work was supported by the National Space Biomedical Research Institute (NSBRI)-Center of Acute Radiation Research (CARR) grant and NIH Training Grant 2T32CA009677 to ALRW. The NSBRI is funded through NASA NCC 9-58. 7 Buonanno M, De Toledo SM, Howell RW, Azzam EI. Low-dose energetic protons induce adaptive and bystander effects that protect human cells against DNA damage caused by a subsequent exposure to energetic iron ions. J Radiat Res. 2015 Mar 23. [Epub ahead of print] http://www.ncbi.nlm.nih.gov/pubmed/25805407 PI:E.I. Azzam Note:This article may be obtained online without charge. Journal Impact Factor:1.691 Funding:This research is supported by NASA Grants NNJ06HD91G and NNX15AD62G. Funding to pay the Open Access publication charges for this article was provided by NASA grant NNX15AD62G. 8 Baulch JE, Craver BM, Tran KK, Yu L, Chmielewski N, Allen BD, Limoli CL. Persistent oxidative stress in human neural stem cells exposed to low fluences of charged particles. Redox Biol. 2015 Aug 11;5:24-32. Epub 2015 Mar 11. http://www.ncbi.nlm.nih.gov/pubmed/25800120 PIs:J.E. Baulch, C.L. Limoli Note:This article may be obtained online without charge. Journal Impact Factor:Not available for this journal. Funding:This work was supported by NASA Grants NNA06CB39G, NX09AK25G and NNX10AD59G (CLL) and NNX13AK69G and NNX13AK70G (JEB). 9 Cho KO, Lybrand ZR, Ito N, Brulet R, Tafacory F, Zhang L, Good L, Ure K, Kernie SG, Birnbaum SG, Scharfman HE, Eisch AJ, Hsieh J. Aberrant hippocampal neurogenesis contributes to epilepsy and associated cognitive decline. Nat Commun. 2015 Mar;6:6606. http://www.ncbi.nlm.nih.gov/pubmed/25808087 PI:A.J. Eisch Note:This article may be obtained online without charge. Journal Impact Factor:10.742 Funding:This work was supported by the National Institutes of Health (NIH) grants (R01AG032383, R01NS076775, R01NS038572 and K02AG041815 to J.H.; R01NS081203 to J.H. and H.E.S.; R01DA016765 and K02DA023555 to A.J.E.), a grant from the National Aeronautics and Atmospheric Association (NASA; NX12AB55G to A.J.E.), American Heart Association training grant (5T32HL007360-34) to Z.R.L. and NIH predoctoral training grant (5T32GM083831-05) to R.B. This work was also supported by a grant from the Texas Institute for Brain Injury and Repair at UT Southwestern and the Welch Foundation I-1660 (to J.H.). _____________________________________________________ Other papers of interest: 1 Ma L, Ma J, Xu K. Effect of spaceflight on the circadian rhythm, lifespan and gene expression ofDrosophila melanogaster. PLoS One. 2015 Mar 23;10(3):e0121600. http://www.ncbi.nlm.nih.gov/pubmed/25798821 Note:Shenzhou 9 results. This article may be obtained online without charge. 2 Fisahn J, Klingel E, Barlow P. Lunar gravity affects leaf movement ofArabidopsis thalianain the International Space Station. http://www.ncbi.nlm.nih.gov/pubmed/25795423 Note:ISS results. 3 Soucek A, Ostkamp L, Paternesi R. Suited versus unsuited analog astronaut performance using the Aouda.X space suit simulator: The DELTA Experiment of MARS2013. http://www.ncbi.nlm.nih.gov/pubmed/25811713 4 Ghislin S, Ouzren-Zarhloul N, Kaminski S, Frippiat JP. Hypergravity exposure during gestation modifies the TCR repertoire of newborn mice. Sci Rep. 2015 Mar 20;5:9318. http://www.ncbi.nlm.nih.gov/pubmed/25792033 Note:Centrifugation was used. This article may be obtained online without charge. 5 Phillips JB, Hrning D, Funke ME. Cognitive and perceptual deficits of normobaric hypoxia and the time course to performance recovery. Aerosp Med Hum Perform. 2015 Apr;86(4):357-65. http://www.ingentaconnect.com/content/asma/amhp/2015/00000086/00000004/art00005 6 Kanekar S, Bogdanova OV, Olson PR, Sung YH, D'Anci KE, Renshaw PF. Hypobaric hypoxia induces depression-like behavior in female Sprague-Dawley rats, but not in males. High Alt Med Biol. 2015 Mar;16(1):52-60. http://www.ncbi.nlm.nih.gov/pubmed/25803141 7 Koch C, Kohn FP, Bauer J. Preparing normal tissue cells for space flight experiments. Prep Biochem Biotechnol. 2015 Mar 25. [Epub ahead of print] http://www.ncbi.nlm.nih.gov/pubmed/25806650 Note:The authors suggest the use of re-differentiable tumor cells for use in space flight experiments. Cell lines listed are derived from melanoma, breast cancer, thyroid carcinoma, and neuroblastoma. 8 Lambrechts K, Pontier JM, Mazur A, Theron M, Buzzacott P, Wang Q, Belhomme M, Guerrero F. Mechanism of action of antiplatelet drugs on decompression sickness in rats: A protective effect of anti-GPIIbIIIa therapy. J Appl Physiol (1985). 2015 Mar 19:jap.00125.2015. [Epub ahead of print] http://www.ncbi.nlm.nih.gov/pubmed/25792711 9 Manen O, Dussault C, Sauvet F, Montmerle-Borgdorff S. Limitations of stroke volume estimation by non-invasive blood pressure monitoring in hypergravity. PLoS One. 2015 Mar 23;10(3):e0121936. http://www.ncbi.nlm.nih.gov/pubmed/25798613 Note:Centrifugation was used. This article may be obtained online without charge. 10 Hodt A, Hisdal J, Stugaard M, Stranden E, Atar D, Steine K. Increased LV apical untwist during preload reduction in healthy humans: An echocardiographic speckle tracking study during lower body negative pressure. Physiol Rep. 2015 Mar;3(3). Epub 2015 Mar 22. http://www.ncbi.nlm.nih.gov/pubmed/25802362 Note:This article may be obtained online without charge. 11 Liu J, Li Y, Verheyden B, Chen S, Chen Z, Gai Y, Liu J, Gao J, Xie Q, Yuan M, Li Q, Li L, Aubert AE. Is autonomic modulation different between European and Chinese astronauts? PLoS One. 2015 Mar 23;10(3):e0120920. http://www.ncbi.nlm.nih.gov/pubmed/25799561 Note:This article may be obtained online without charge. 12 Barbic F, Heusser K, Marchi A, Zamuner AR, Gauger P, Tank J, Jordan J, Diedrich A, Robertson D, Dipaola F, Achenza S, Porta A, Furlan R. Cardiovascular parameters and neural sympathetic discharge variability before orthostatic syncope: Role of sympathetic baroreflex control to the vessels. Physiol Meas. 2015 Mar 23;36(4):633-41. [Epub ahead of print] http://www.ncbi.nlm.nih.gov/pubmed/25798786 Note:This article may be obtained online without charge. 13 Wang C, Chen H, Luo H, Zhu L, Zhao Y, Tian H, Wang R, Shang P, Zhao Y. Microgravity activates p38 MAPK-C/EBP pathway to regulate the expression of arginase and inflammatory cytokines in macrophages. Inflamm Res. 2015 Mar 25. [Epub ahead of print] http://www.ncbi.nlm.nih.gov/pubmed/25804385 Note:A Rotary Cell Culture System (RCCS-1) was used. 14 Yan M, Wang Y, Yang M, Liu Y, Qu B, Ye Z, Liang W, Sun X, Luo Z. The effects and mechanisms of clinorotation on proliferation and differentiation in bone marrow mesenchymal stem cells. Biochem Biophys Res Commun. 2015 Mar 21. [Epub ahead of print] http://www.ncbi.nlm.nih.gov/pubmed/25804637 Note:Clinorotation was used. 15 Sun X, Yang K, Wang C, Cao S, Merritt M, Hu Y, Xu X. Paradoxical response to mechanical unloading in bone loss, microarchitecture, and bone turnover markers. Int J Med Sci. 2015 Mar 1;12(3):270-9. http://www.ncbi.nlm.nih.gov/pubmed/25798053 Note:Unloading was accomplished through bilateral sciatic neurectomy. This article may be obtained online without charge. 16 Hashemian SJ, Rismanchi M, Esfahani EN, Khoshvaghti A, Razi F. Effect of calcitriol supplementation and tail suspension on serum biomarkers of bone formation in rats. J Diabetes Metab Disord. 2015 Mar 19;14:14. http://www.ncbi.nlm.nih.gov/pubmed/25806360 Note:Hindlimb unloading study. This article may be obtained online without charge. 17 Wei J, Karsenty G. An overview of the metabolic functions of osteocalcin. Curr Osteoporos Rep. 2015 Mar 26. [Epub ahead of print] Review. http://www.ncbi.nlm.nih.gov/pubmed/25809656 Note:Publishers note on first page This article is part of the Topical Collection onBone and Diabetes. 18 Smirnova OA. Myeloid leukemia risk assessment and dynamics of the granulocytopoietic system in acutely and continuously irradiated humans: Modeling approach. Health Phys. 2015 May;108(5):492-502. http://www.ncbi.nlm.nih.gov/pubmed/25811147 19 Khler J, Ehresmann B, Zeitlin C, Wimmer-Schweingruber RF, Hassler DM, Reitz G, Brinza DE, Appel J, Bttcher S, Bhm E, Burmeister S, Guo J, Lohf H, Martin C, Posner A, Rafkin S. Measurements of the neutron spectrum in transit to Mars on the Mars Science Laboratory. Life Sci Space Res. 2015 Mar 24. [Article in Press] http://www.sciencedirect.com/science/article/pii/S2214552415000164 20 Kobashigawa S, Kashino G, Suzuki K, Yamashita S, Mori H. Ionizing radiation-induced cell death is partly caused by increase of mitochondrial reactive oxygen species in normal human fibroblast cells. Radiat Res. 2015 Mar 25. [Epub ahead of print] http://www.ncbi.nlm.nih.gov/pubmed/25807320 21 Ebrahimian T, Le Gallic C, Stefani J, Dublineau I, Yentrapalli R, Harms-Ringdahl M, Haghdoost S. Chronic gamma-irradiation induces a dose-rate-dependent pro-inflammatory response and associated loss of function in human umbilical vein endothelial cells. Radiat Res. 2015 Mar 25. [Epub ahead of print] http://www.ncbi.nlm.nih.gov/pubmed/25807321 22 Di Trolio R, Di Lorenzo G, Fumo B, Ascierto PA. Cosmic radiation and cancer: Is there a link? Future Oncol. 2015 Apr;11(7):1123-35. Review. http://www.ncbi.nlm.nih.gov/pubmed/25804126 23 Collet G, Mairesse O, Cortoos A, Tellez HF, Neyt X, Peigneux P, Macdonald-Nethercott E, Ducrot Y-M, Pattyn N. Altitude and seasonality impact on sleep in Antarctica. Aerosp Med Hum Perform. 2015 Apr;86(4):392-6. http://www.ingentaconnect.com/content/asma/amhp/2015/00000086/00000004/art00010 24 Van Benthem KD, Herdman CM, Tolton RG, LeFevre J-A. Prospective memory failures in aviation: Effects of cue salience, workload, and individual differences. Aerosp Med Hum Perform. 2015 Apr;86(4):366-73. http://www.ingentaconnect.com/content/asma/amhp/2015/00000086/00000004/art00006 25 Matthews G, Reinerman-Jones LE, Barber DJ, Abich J 4th. The psychometrics of mental workload: Multiple measures are sensitive but divergent. Hum Factors. 2015 Feb;57(1):125-43. http://www.ncbi.nlm.nih.gov/pubmed/25790574 26 Tang Y, Gao F, Guo S, Li F. The morphology, physiology and nutritional quality of lettuce grown under hypobaria and hypoxia. Acta Astronaut. 2015 Jul-Aug;112:29-36. http://www.sciencedirect.com/science/article/pii/S0094576515000879

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NASA Spaceline Current Awareness List #644 - 3 April 2015