Papers deriving from NASA support: 1 Inan O, Migeotte PF, Park KS, Etemadi M, Tavakolian K, Casanella R, Zanetti J, Tank J, Funtova I, Prisk K, Di Rienzo M. Ballistocardiography and seismocardiography: A review of recent advances. IEEE J Biomed Health Inform. 2014 Oct 7. [Epub ahead of print] Review. http://www.ncbi.nlm.nih.gov/pubmed/25312966 (PI: G.K. Prisk) Journal Impact Factor:2.072 Funding:P. F. Migeotte was supported by the Belgian Federal Science Policy Office via the European Space Agency PRODEX program (ILSRA-2009-0729). G. K. Prisk was supported by the National Space Biomedical Research Institute through NASA NCC9-58. J. Tank and I. I. Funtova were supported by the German Space Agency (DLR) grant 50WB1117. M. Di Rienzo was partially supported by the Italian Space Agency through ASI 2013-061-I.0 and ASI 2013-079-R.0. 2 Broxterman RM, Ade CJ, Craig JC, Wilcox SL, Schlup SJ, Barstow TJ. The relationship between critical speed and the respiratory compensation point: Coincidence or equivalence. Eur J Sport Sci. 2014 Oct 13:1-9. [Epub ahead of print] http://www.ncbi.nlm.nih.gov/pubmed/25307937 (PI: T.J. Barstow) Journal Impact Factor:1.314 Funding:This work was supported by the National Aeronautics and Space Administration (NASA) under Grant [grant number NNX10AK60G] awarded to T.J. Barstow; NASA Experimental programme to Stimulate Competitive Research (EPSCoR) under Grant [grant number NNX11AM05A] supporting R.M. Broxterman. 3 Pollak L, Mehta SK, Pierson DL, Sacagiu T, Avneri Kalmanovich S, Cohrs RJ. Varicella-zoster DNA in saliva of patients with meningoencephalitis: A preliminary study. Acta Neurol Scand. 2014 Oct 14. [Epub ahead of print] http://www.ncbi.nlm.nih.gov/pubmed/25314141 Journal Impact Factor:2.437 Funding:This work has not received any funding. D.L. Pierson is at NASA Johnson Space Center. 4 Brooks NE, Cadena SM, Cloutier G, Vega-Lpez S, Roubenoff R, Castaneda-Sceppa C. Influence of exercise on the metabolic profile caused by 28 days of bed rest with energy deficit and amino acid supplementation in healthy men. Int J Med Sci. 2014 Sep 21;11(12):1248-57. http://www.ncbi.nlm.nih.gov/pubmed/25317071 (PIs: C. Castaneda-Sceppa, R. Roubenoff) Note:Bed rest study. This article may be obtained online without charge. Journal Impact Factor:1.552 Funding:This work was supported by the National Space Biomedical Research Institute (NSBRI; NCC9-58), the U.S. Department of Agriculture (ARS Agreement 58-1950-9-001), the National Institutes of Health (NIH; M01 RR000054). S.M.C was supported in part by the NIH (T32 DK62032-11). 5 Flck M, Li R, Valdivieso P, Linnehan RM, Castells J, Tesch P, Gustafsson T. Early changes in costameric and mitochondrial protein expression with unloading are muscle specific. Biomed Res Int. 2014;2014:519310. Epub 2014 Sep 16. http://www.ncbi.nlm.nih.gov/pubmed/25313365 Note:Unilateral lower limb suspension was used. This article may be obtained online without charge. Journal Impact Factor:2.706 Funding:The authors acknowledge partial financial support by EU FP7 grant Myoage (Contract no. 223576), SNSB (Per Tesch), and NASA (Richard M. Linnehan). R.M. Linnehan is at NASA Johnson Space Center. 6 Illa-Bochaca I, Ouyang H, Tang J, Sebastiano C, Mao JH, Costes SV, Demaria S, Barcellos-Hoff MH. Densely ionizing radiation acts via the microenvironment to promote aggressive Trp53 null mammary carcinomas. Cancer Res. 2014 Oct 10. pii: canres.1212.2014. [Epub ahead of print] http://www.ncbi.nlm.nih.gov/pubmed/25304265 (PI: M.H. Barcellos-Hoff/J.H. Mao/S.V. Costes/S. Demaria/NSCOR) Journal Impact Factor:9.284 Funding:This research was supported by NASA Specialized Center for Research in Radiation Health Effects, NNX09AM52G. 7 Link BM, Busse JS, Stankovic B. Seed-to-seed-to-seed growth and development ofArabidopsisin microgravity. http://www.ncbi.nlm.nih.gov/pubmed/25317938 Note:ISS results. This article, which may be obtained online without charge, is featured on the cover of the journal: Images ofArabidopsis thalianaplants grown on the International Space Station, compared with ground-grown controls Journal Impact Factor:2.512 Funding:This experiment was funded, in part, by Space Explorers, Inc. ADVASC development was sponsored by a NASA SPD grant under Cooperative Agreement number NCC8-129. _________________________________________________________________________ Other papers of interest: 1 Guo J, Han N, Zhang Y, Wang H, Zhang X, Su L, Liu C, Li J, Chen C, Liu C. Use of genome sequencing to assess nucleotide structure variation ofStaphylococcus aureusstrains cultured in spaceflight on Shenzhou-X, under simulated microgravity and on the ground. Microbiol Res. 2014 Sep 16. pii: S0944-5013(14)00108-6. [Epub ahead of print] http://www.ncbi.nlm.nih.gov/pubmed/25304992 Note:Shenzhou 10 results. Low-shear modeled microgravity was used for ground-based experiments. 2 Adell T, Sal E, van Loon JJ, Auletta G. Planarians sense simulated microgravity and hypergravity. Biomed Res Int. 2014;2014:679672. Epub 2014 Sep 17. http://www.ncbi.nlm.nih.gov/pubmed/25309918 Note:A random positioning machine was used to simulate microgravity; centrifugation was used for hypergravity. This article may be obtained online without charge. 3 Fedorov VB, Goropashnaya AV, Stewart NC, Tien O, Chang C, Wang H, Yan J, Showe LC, Showe MK, Barnes BM. Comparative functional genomics of adaptation to muscular disuse in hibernating mammals. Mol Ecol. 2014 Oct 14. [Epub ahead of print] http://www.ncbi.nlm.nih.gov/pubmed/25314618 4 Ishihara A, Nagatomo F, Terada M, Fujino H, Kondo H, Ishioka N. Effects of microgravity on the mouse triceps brachii muscle. Muscle Nerve. 2014 Oct 12. [Epub ahead of print] http://www.ncbi.nlm.nih.gov/pubmed/25307981 Note:STS-135 results. From the Methods section: This study was carried out as a NASA Biospecimen Sharing Program, which was a part of Commercial Biomedical Testing Module-3 (CBTM-3-Vascular Atrophy) project. 5 Hu LF, Li JB, Qian AR, Wang F, Shang P. Mineralization initiation of MC3T3-E1 preosteoblast is suppressed under simulated microgravity condition. Cell Biol Int. 2014 Oct 16. [Epub ahead of print] http://www.ncbi.nlm.nih.gov/pubmed/25318973 Note:A random positioning machine was used. 6 Yi JY, Kim MR, Lee J, An YS, Jin YB, Park IC, Chung E, Shin I, Barcellos-Hoff MH. TGF-beta1 protects cells from gamma-IR by enhancing the activity of the NHEJ repair pathway. Mol Cancer Res. 2014 Oct 15. pii: molcanres.0098.2014. [Epub ahead of print] http://www.ncbi.nlm.nih.gov/pubmed/25319009 7 Neri G, Mascotti G, Zolesi V. ELITE S2 A facility for quantitative human movement analysis on board the ISS. Microgravity Sci Technol. 2014 Oct 14. [Article in Press] http://link.springer.com/article/10.1007/s12217-014-9396-7 8 Bagriantsev SN, Gracheva EO, Gallagher PG. Piezo proteins: Regulators of mechanosensation and other cellular processes. J Biol Chem. 2014 Oct 10. pii: jbc.R114.612697. [Epub ahead of print] Review. http://www.ncbi.nlm.nih.gov/pubmed/25305018 Note:This article may be obtained online without charge. 9 Compton JL, Luo JC, Ma H, Botvinick E, Venugopalan V. High-throughput optical screening of cellular mechanotransduction. Nat Photonics. 2014 Sep 1;8:710-715. http://www.ncbi.nlm.nih.gov/pubmed/25309621 10 Cho M, Henry EM, Lewis DR, Wu G, Muday GK, Spalding E. Block of ABCB19 ion channel activity by 5-nitro-2-(3-phenylpropylamino)-benzoic acid (NPPB) impairs polar auxin transport and root gravitropism. Plant Physiol. 2014 Oct 16. pii: pp.114.250860. [Epub ahead of print] http://www.ncbi.nlm.nih.gov/pubmed/25324509 Note:This article may be obtained online without charge. 11 Sanz L, Fernndez-Marcos M, Modrego A, Lewis DR, Muday GK, Pollmann S, Dueas M, Santos-Buelga C, Lorenzo O. Nitric oxide plays a role in stem cell niche homeostasis through its interaction with auxin. Plant Physiol. 2014 Oct 14. pii: pp.114.247445. [Epub ahead of print] http://www.ncbi.nlm.nih.gov/pubmed/25315603 Note:This article may be obtained online without charge. 12 Zhao H, Ma T, Wang X, Deng Y, Ma H, Zhang R, Zhao J. OsAUX1 controls lateral root initiation in rice (Oryza sativaL.). Plant Cell Environ. 2014 Oct 13. [Epub ahead of print] http://www.ncbi.nlm.nih.gov/pubmed/25311360 13 Li M, Sack FD. Myrosin idioblast cell fate and development are regulated by theArabidopsistranscription factor FAMA, the auxin pathway, and vesicular trafficking. Plant Cell. 2014 Oct 10. pii: tpc.114.129726. [Epub ahead of print] http://www.ncbi.nlm.nih.gov/pubmed/25304201

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NASA Spaceline Current Awareness List #621 24 October 2014