Papers deriving from NASA support: 1 Taibbi G, Cromwell RL, Zanello SB, Yarbough PO, Ploutz-Snyder RJ, Godley BF, Vizzeri G. Ocular outcomes evaluation in a 14-day head-down bed rest study. Aviat Space Environ Med. 2014 Oct;85(10):983-92. http://www.ncbi.nlm.nih.gov/pubmed/25245897 (PI: R.L. Cromwell) Note:Bed rest study. Journal Impact Factor:1.238 Funding:This study was supported by NASA Flight Analogs Project 516724.03.04.01; NIH/NCRR 1UL1RR029876-01. 2 Sarper H, Blanton C, DePalma J, Melnykov IV, Gabaldn AM. Simulated weightlessness and synbiotic diet effects on rat bone mechanical strength. Life Sci Space Res. 2014 Sep 30. [Article in Press] http://www.sciencedirect.com/science/article/pii/S2214552414000492 Journal Impact Factor:1.183 Funding:This research was supported by grants awarded by the National Aeronautics and Space Administration, Idaho and Colorado Space Grant Consortiums. 3 Werner E, Wang H, Doetsch PW. Opposite roles for p38MAPK-driven responses and reactive oxygen species in the persistence and resolution of radiation-induced genomic instability. PLoS One. 2014 Oct 1;9(10):e108234. http://www.ncbi.nlm.nih.gov/pubmed/25271419 (PIs: Y. Wang/H. Wang/P.W. Doetsch/NSCOR) Note:This article may be obtained online without charge. Journal Impact Factor:3.534 Funding:This work is supported by a National Aeronautics and Space Administration (NASA) Grant NNX11AC30G. 4 Vadhavkar N, Pham C, Georgescu W, Deschamps T, Heuskin AC, Tang J, Costes SV. Combinatorial DNA damage pairing model based on X-ray-induced foci predicts the dose and LET dependence of cell death in human breast cells. Radiat Res. 2014 Sep;182(3):273-81. Epub 2014 Jul 30. http://www.ncbi.nlm.nih.gov/pubmed/25076115 (PIs: M.H. Barcellos-Hoff/S.V. Costes/NSCOR) Journal Impact Factor:2.445 Funding:SVC, WG, TD, JT are supported by NASA Specialized Center for Research in Radiation Health Effects [NNJ09HC64I] and the Low Dose Scientific Focus Area, United States Department of Energy [DE-AC02-05CH11231]. NV is supported by the National Space Biomedical Research Institute (grant no. NCC-9-58). 5 Strangman GE, Sipes W, Beven G. Human cognitive performance in spaceflight and analogue environments. Aviat Space Environ Med. 2014 Oct;85(10):1033-48. Review. http://www.ncbi.nlm.nih.gov/pubmed/25245904 Journal Impact Factor:1.238 Funding:This work was supported by Wyle, Science, Technology and Engineering, subcontract number 171712. G. Beven is at NASA Johnson Space Center. 6 Bamsey MT, Paul AL, Graham T, Ferl RJ. Flexible imaging payload for real-time fluorescent biological imaging in parabolic, suborbital and space analog environments. Life Sci Space Res. 2014 Sep 28. [Article in Press] http://www.sciencedirect.com/science/journal/aip/22145524 (PI: R.J. Ferl) Journal Impact Factor:1.183 Funding:This work was partly supported by a UCF-UF Space Research Initiative Award 66014402), the NASA Flight Opportunities Office, NASA grants NNX13AM46G and NNX12AN69G, as well as the NASA Postdoctoral Program (NPP) for partial support of Thomas Grahams activities. 7 Stefano G, Hawes C, Brandizzi F. ER - The key to the highway. Curr Opin Plant Biol. 2014 Sep 26;22C:30-38. [Epub ahead of print] Review. http://www.ncbi.nlm.nih.gov/pubmed/25259957 (PI: F. Brandizzi) Journal Impact Factor:9.385 Funding:This work was supported by grants from the Chemical Sciences, Geosciences and Biosciences Division, Office of Basic Energy Sciences, Office of Science, U.S. DOE (DE-FG02-91ER20021) for the infrastructure, National Institutes of Health (R01 GM101038), NSF (MCB 1243792), NASA (NNX12AN71G) and the Leverhulme Trust (F/00 382/G). 8 Keeton KE, Richard EE, Davis JR. Solution mechanism guide: Implementing innovation within a research & development organization. Aviat Space Environ Med. 2014 Oct;85(10):1061-2. Commentary. http://www.ncbi.nlm.nih.gov/pubmed/25245908 Journal Impact Factor:1.238 Funding:No funding acknowledged. J.R. Davis is at NASA Johnson Space Center. _____________________________________________________________________________ Other papers of interest: 1 Bilancio G, Lombardi C, Pisot R, De Santo NG, Cavallo P, Cirillo M. Effects of bed-rest on urea and creatinine: Correlation with changes in fat-free mass. PLoS One. 2014 Sep 29;9(9):e108805. http://www.ncbi.nlm.nih.gov/pubmed/25265226 Note:Bed rest study. This article may be obtained online without charge. 2 Gempp E, De Maistre S, Louge P. Serum albumin as a biomarker of capillary leak in scuba divers with neurological decompression sickness. Aviat Space Environ Med. 2014 Oct;85(10):1049-52. http://www.ncbi.nlm.nih.gov/pubmed/25245905 3 Limper U, Gauger P, Beck P, Krainski F, May F, Beck LE. Interactions of the human cardiopulmonary, hormonal and body fluid systems in parabolic flight. Eur J Appl Physiol. 2014 Jun;114(6):1281-95. Epub 2014 Mar 13. http://www.ncbi.nlm.nih.gov/pubmed/24623065 Note:Parabolic flight results. This article may be obtained online without charge. 4 Leguy CA, Beck P, Gauger P, Beck LE, Limper U. Carotid arterial wall dynamics during gravity changes on partial-g parabolic flights. Microgravity Sci Technol. 2014 Oct;26(2):111-7. http://link.springer.com/article/10.1007/s12217-014-9381-1 Note:Parabolic flight results. This article may be obtained online without charge. 5 Zaripova RI, Gainutdinov KhL, Zefirov TL. Effect of NO synthase blockade on NO production in rat heart under conditions of hypokinesia. Bull Exp Biol Med. 2014 Sep;157(5):545-7. Epub 2014 Sep 27. http://www.ncbi.nlm.nih.gov/pubmed/25257408 6 Pisanu ME, Noto A, De Vitis C, Masiello MG, Coluccia P, Proietti S, Giovagnoli MR, Ricci A, Giarnieri E, Cucina A, Ciliberto G, Bizzarri M, Mancini R. Lung cancer stem cell lose their stemness default state after exposure to microgravity. Biomed Res Int. 2014;2014:470253. Epub 2014 Sep 7. http://www.ncbi.nlm.nih.gov/pubmed/25276790 Note:A random positioning machine was used. This article may be obtained online without charge. 7 Tyapkina OV, Volkov EM, Nurullin LF. The role of chloride ions in the maintenance of resting membrane potential in rat fast and slow muscles during hypogravity modeling. Bull Exp Biol Med. 2014 Sep;157(5):577-9. Epub 2014 Sep 27. http://www.ncbi.nlm.nih.gov/pubmed/25257417 Note:Hindlimb unloading study. 8 Clark BC, Mahato N, Nakazawa M, Law T, Thomas J. The power of the mind: The cortex as a critical determinant of muscle strength/weakness. J Neurophysiol. 2014 Oct 1. pii: jn.00386.2014. [Epub ahead of print] http://www.ncbi.nlm.nih.gov/pubmed/25274345 Note:From the Introduction: In the present experiment, we sought to test the hypothesis that the cortex is a critical determinant of muscle strength/weakness and VA [voluntary (neural) activation], and that high levels of intracortical inhibition is an important neurophysiologic factor regulating strength/weakness. 9 Xing Y, Gu Y, Bresnahan JJ, Paul EM, Donahue HJ, You J. The roles of P2Y2 purinergic receptors in osteoblasts and mechanotransduction. PLoS One. 2014 Sep 30;9(9):e108417. http://www.ncbi.nlm.nih.gov/pubmed/25268784 Note:This article may be obtained online without charge. 10 Dai Z, Guo F, Wu F, Xu H, Yang C, Li J, Liang P, Zhang H, Qu L, Tan Y, Wan Y, Li Y. Integrin v3 mediates the synergetic regulation of core-binding factor 1 transcriptional activity by gravity and insulin-like growth factor-1 through phosphoinositide 3-kinase signaling. http://www.ncbi.nlm.nih.gov/pubmed/25263523 Note:A clinostat was used to simulate microgravity and a cell centrifuge was used for hypergravity. 11 Xiao E, Yang H, Gan YH, Duan DH, He LH, Guo Y, Wang S, Zhang Y. TRPM7 senses mechanical stimulation inducing osteogenesis in human bone marrow mesenchymal stem cells. Stem Cells. 2014 Sep 29. [Epub ahead of print] http://www.ncbi.nlm.nih.gov/pubmed/25263397 12 Maeda J, Bell JJ, Genet SC, Fujii Y, Genet MD, Brents CA, Genik PC, Kato TA. Potentially lethal damage repair in drug arrested G(2)-phase cells after radiation exposure. Radiat Res. 2014 Sep 24. [Epub ahead of print] http://www.ncbi.nlm.nih.gov/pubmed/25251700 13 Belov OV, Krasavin EA, Lyashko MS, Batmunkh M, Sweilam NH. A quantitative model of the major pathways for radiation-induced DNA double-strand break repair. J Theor Biol. 2014 Sep 26. pii: S0022-5193(14)00563-3. [Epub ahead of print] http://www.ncbi.nlm.nih.gov/pubmed/25261728 14 Saradjian AH, Paleressompoulle D, Louber D, Coyle T, Blouin J, Mouchnino L. Do gravity-related sensory information enable the enhancement of cortical proprioceptive inputs when planning a step in microgravity? PLoS One. 2014 Sep 26;9(9):e108636. http://www.ncbi.nlm.nih.gov/pubmed/25259838 Note:Parabolic flight results. This article may be obtained online without charge. 15 Lundberg YW, Xu Y, Thiessen KD, Kramer KL. Mechanisms of otoconia and otolith development. Dev Dyn. 2014 Sep 25. [Epub ahead of print] Review. http://www.ncbi.nlm.nih.gov/pubmed/25255879 16 Branoner F, Straka H. Semicircular canal-dependent developmental tuning of translational vestibulo-ocular reflexes inXenopus laevis. Dev Neurobiol. 2014 Sep 30. [Epub ahead of print] http://www.ncbi.nlm.nih.gov/pubmed/25266079 17 Hohm T, Demarsy E, Quan C, Allenbach Petrolati L, Preuten T, Vernoux T, Bergmann S, Fankhauser C. Plasma membrane H+-ATPase regulation is required for auxin gradient formation preceding phototropic growth. Mol Syst Biol. 2014 Sep 26;10(9):751. http://www.ncbi.nlm.nih.gov/pubmed/25261457 Note:This article may be obtained online without charge. 18 Qin L, Yu Q, Ai W, Tang Y, Ren J, Guo S. Response of cyanobacteria to low atmospheric pressure. Life Sci Space Res. 2014 Sep 28. http://www.sciencedirect.com/science/article/pii/S2214552414000479 Note:The study examines the effect of a low pressure environment on cyanobacteria grown in a controlled ecological life support system designed for a lunar base. 19 Lu Y, Ding C, Wang J, Shang P. An illuminated growth system for the study ofArabidopsis thalianaduring diamagnetic levitation by a superconducting magnet. Adv Space Res. 2014 Sep 22. [Article in Press] http://www.sciencedirect.com/science/article/pii/S0273117714005857 Note:From the abstract: difficulties exist in evaluating the effects of simulated microgravity on plant seedling growth under lighting conditions. Therefore, we developed a lighting system and culturing system that can meet the demands of growing plant seedlings in a superconducting magnet. This article may be obtained online without charge. 20 Sangaletti R, Dahl G, Bianchi L. Mechanosensitive unpaired innexin channels inC. eleganstouch neurons. Am J Physiol Cell Physiol. 2014 Sep 24. pii: ajpcell.00246.2014. [Epub ahead of print] http://www.ncbi.nlm.nih.gov/pubmed/25252948 21 Bellas E, Chen CS. Forms, forces, and stem cell fate. Curr Opin Cell Biol. 2014 Sep 27;31C:92-97. [Epub ahead of print] Review. http://www.ncbi.nlm.nih.gov/pubmed/25269668 Note:From the abstract: we highlight mechanisms that alter cell shape and mechanics, and the pathways affected by these changes. 22 Tsai TT, Cheng CM, Chen CF, Lai PL. Mechanotransduction in intervertebral discs. J Cell Mol Med. 2014 Sep 30. [Epub ahead of print] Review. http://www.ncbi.nlm.nih.gov/pubmed/25267492 Note:This article may be obtained online without charge. 23 Burchell MJ. Human spaceflight and an asteroid redirect mission: Why? Space Policy. 2014 Sep 24. http://www.sciencedirect.com/science/article/pii/S0265964614000629 24 Evetts SN. Space life and biomedical sciences in support of the global exploration roadmap and societal development. Space Policy. 2014 Sep 26. http://www.sciencedirect.com/science/article/pii/S0265964614000691

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NASA Spaceline Current Awareness List #619 10 October 2014