Our recent research article "In-vitro Topographical Model of Fuchs Dystrophy for Evaluation of Corneal Endothelial Cell Monolayer Formation" appeared on theBack cover of Advanced Healthcare Materials latest issue.
Several diseases have been known to be caused by microstructural changes in the extracellular microenvironment. Therefore, the knowledge of the interaction of cells with the altered extracellular micro-structures or surface topography is critical to develop a better understanding of the disease for therapeutic development. One such disease is Fuchs corneal endothelial dystrophy (FED). FED is the primary disease and major reason of corneal endothelial cell death. If left untreated, corneal blindness will be resulted; thus, FED is the leading indication for corneal transplantation. In the USA, 4% of population over the age of 40 is believed to have compromised corneal endothelium due to FED, which will further increase due to increasing life expectancy and rapidly ageing population. A diagnostic clinical hallmark of FED is the development of discrete pillar or dome-like microstructures on the corneal endothelial basement membrane (Descemet membrane). These microstructures are called corneal guttata or guttae. Cell therapies have been proposed as an alternative treatment method for Fuchs dystrophy patients. However, currently, no in-vitro or in-vivo FED disease model is available to study the cell therapies before clinical trials.
In this study, the pathological changes in the micro-structure of basement membranes resulting from FED disease was analyzed, to identify geometrical dimension to develop an in-vitro disease model of synthetic corneal guttata pillars/domes by using microfabrication techniques. This model was used to study the monolayer formation of donor-derived human corneal endothelial cells to test the effectiveness of the corneal endothelial cell regenerative therapies. The results suggest that the corneal cell therapies may not be equally effective for patients at different stages of disease progression. The pre-existing guttata in patients could interfere with the cells thus hampering monolayer formation within the eye. Surgical removal of the guttata from the diseased Descemet membrane prior to cell regenerative therapy could increase the success rate of monolayer formation, which could potentially increase the chances of cell therapy success. This study also demonstrate how biomaterial design can be employed to mimic the pathological microstructural changes in basement membranes for better understanding of cellular responses in disease conditions.
Read the original here:
- Is there an alternative to radiation [Last Updated On: November 8th, 2009] [Originally Added On: November 8th, 2009]
- Taiwan exploring how nanotech affects health [Last Updated On: November 8th, 2009] [Originally Added On: November 8th, 2009]
- A new way of treating cancer on the way? [Last Updated On: November 8th, 2009] [Originally Added On: November 8th, 2009]
- Lasers can destroy cancer cells [Last Updated On: November 8th, 2009] [Originally Added On: November 8th, 2009]
- Fluorescent molecules can be biomarkers [Last Updated On: November 8th, 2009] [Originally Added On: November 8th, 2009]
- Quick blood tests by using a nanodevice [Last Updated On: November 8th, 2009] [Originally Added On: November 8th, 2009]
- Where will medicine be 20 years from now [Last Updated On: November 8th, 2009] [Originally Added On: November 8th, 2009]
- History of nanotechnology [Last Updated On: November 8th, 2009] [Originally Added On: November 8th, 2009]
- Nanotech and Cancer [Last Updated On: November 8th, 2009] [Originally Added On: November 8th, 2009]
- Nanotechnology in medicine [Last Updated On: November 8th, 2009] [Originally Added On: November 8th, 2009]
- How does cancer start [Last Updated On: January 25th, 2010] [Originally Added On: January 25th, 2010]
- Lung cancer symptoms [Last Updated On: January 26th, 2010] [Originally Added On: January 26th, 2010]
- Signs of breast cancer [Last Updated On: January 27th, 2010] [Originally Added On: January 27th, 2010]
- Famous people with cancer [Last Updated On: January 29th, 2010] [Originally Added On: January 29th, 2010]
- Metastatic renal cancer [Last Updated On: January 30th, 2010] [Originally Added On: January 30th, 2010]
- What causes skin cancer [Last Updated On: January 31st, 2010] [Originally Added On: January 31st, 2010]
- How many people die from cancer each year [Last Updated On: February 1st, 2010] [Originally Added On: February 1st, 2010]
- How much money is spent on cancer research [Last Updated On: February 2nd, 2010] [Originally Added On: February 2nd, 2010]
- Colon cancer warning signs [Last Updated On: February 4th, 2010] [Originally Added On: February 4th, 2010]
- Prostate cancer symptoms [Last Updated On: February 4th, 2010] [Originally Added On: February 4th, 2010]
- Carla wants to know [Last Updated On: August 17th, 2024] [Originally Added On: November 7th, 2010]
- I believe in Renewable Energy, and here's why [Last Updated On: August 17th, 2024] [Originally Added On: May 8th, 2011]
- I believe in Renewable Energy, and here's why [Last Updated On: August 17th, 2024] [Originally Added On: May 8th, 2011]
- Nanotechnology : Ms S. Naidoo - Nano Drug Delivery.wmv [Last Updated On: August 17th, 2024] [Originally Added On: October 12th, 2011]
- NanoMedicine Cancer Drug Delivery - Video [Last Updated On: August 17th, 2024] [Originally Added On: October 13th, 2011]
- ELSI of Regenerative Nanomedicine, Part 5 - Video [Last Updated On: August 17th, 2024] [Originally Added On: October 13th, 2011]
- DtaS - Nanomedicine - Part 2 - Video [Last Updated On: August 17th, 2024] [Originally Added On: October 16th, 2011]
- 2006 Winter, Nanomedicine A New Frontier for Physics - Video [Last Updated On: August 17th, 2024] [Originally Added On: October 25th, 2011]
- Brian Plouffe on Nanomedicine IGERT @ Northeastern - Video [Last Updated On: August 17th, 2024] [Originally Added On: October 29th, 2011]
- Nanomedicine in Europe: present and for the future - Video [Last Updated On: August 17th, 2024] [Originally Added On: November 1st, 2011]
- The Ethics of Nanomedicine, nanomedicine ethics , ethics in nanomedicine - Video [Last Updated On: August 17th, 2024] [Originally Added On: November 7th, 2011]
- Question to Alain Herrera about nanomedicine future - Video [Last Updated On: August 17th, 2024] [Originally Added On: November 7th, 2011]
- Nanomedicine MSc - A Student Perspective - Video [Last Updated On: August 17th, 2024] [Originally Added On: November 8th, 2011]
- Nanomedicine | Insights [Last Updated On: August 17th, 2024] [Originally Added On: November 9th, 2011]
- ELSI in Regenerative Nanomedicine, Part 2 - Video [Last Updated On: August 17th, 2024] [Originally Added On: November 16th, 2011]
- IdeasLab: Breakthroughs in Nanomedicine - Sonia Trigueros - Video [Last Updated On: August 17th, 2024] [Originally Added On: December 27th, 2011]
- Nanomedicine Panel BioEurope 2011 - manufacturing in nanomedicine - Video [Last Updated On: August 17th, 2024] [Originally Added On: December 29th, 2011]
- Nanomedicine Panel BioEurope 2011 - choice to work in nanomedicine - Video [Last Updated On: August 17th, 2024] [Originally Added On: January 1st, 2012]
- Nanomedicine Panel BioEurope 2011 - importance of safety in nanomedicine - Video [Last Updated On: August 17th, 2024] [Originally Added On: January 6th, 2012]
- Nanomedicine Panel BioEurope 2011 - communicate with regulatory agencies - Video [Last Updated On: August 17th, 2024] [Originally Added On: January 6th, 2012]
- Bertrand Loubaton - Contribution of Nanomedicine to the global societal challenges - Video [Last Updated On: August 17th, 2024] [Originally Added On: January 19th, 2012]
- Nanomedicine Panel BioEurope 2011 - Introduction by Laurent Levy - Video [Last Updated On: August 17th, 2024] [Originally Added On: January 19th, 2012]
- Nanomedicine Panel BioEurope 2011 - clinical development - Video [Last Updated On: August 17th, 2024] [Originally Added On: January 19th, 2012]
- Nanomedicine - YouTube.flv - Video [Last Updated On: August 17th, 2024] [Originally Added On: January 19th, 2012]
- Warren Chan - Nanomedicine (part 1) - Video [Last Updated On: August 17th, 2024] [Originally Added On: January 20th, 2012]
- Nanomedicine Panel BioEurope 2011 - expiration of patents - Video [Last Updated On: August 17th, 2024] [Originally Added On: February 2nd, 2012]
- Nano tech is subject of pub talk [Last Updated On: August 17th, 2024] [Originally Added On: February 7th, 2012]
- President Obama Speaking about Nanotechnology [Last Updated On: August 17th, 2024] [Originally Added On: February 7th, 2012]
- OU nanoparticle research may fight cancer cells [Last Updated On: August 17th, 2024] [Originally Added On: February 7th, 2012]
- NanoYou - an introduction to Nanoscience narrated by Stephen Fry - Video [Last Updated On: August 17th, 2024] [Originally Added On: February 7th, 2012]
- NanoMEDICINE and human upper limit - Video [Last Updated On: August 17th, 2024] [Originally Added On: February 7th, 2012]
- NANOMOL Technology Platform - Video [Last Updated On: August 17th, 2024] [Originally Added On: February 7th, 2012]
- Podcast : Nano Sized Medicine - Video [Last Updated On: August 17th, 2024] [Originally Added On: February 7th, 2012]
- Medical Nanotechnology - James Stranger - Current Student Experience - Video [Last Updated On: August 17th, 2024] [Originally Added On: February 12th, 2012]
- Local biotech company hopes save lives by focusing on microscopic cancer cells [Last Updated On: August 17th, 2024] [Originally Added On: February 13th, 2012]
- Tai chi helps ease symptoms of Parkinson's disease, study says [Last Updated On: August 17th, 2024] [Originally Added On: February 13th, 2012]
- Research and Markets: Handbook of Multiphase Polymer Systems, 2 Volume Set Is Ideal for Researchers in both Industry ... [Last Updated On: August 17th, 2024] [Originally Added On: February 15th, 2012]
- TES the largest network of teachers in the world [Last Updated On: August 17th, 2024] [Originally Added On: February 15th, 2012]
- Study implants chip that oozes out a daily dose of medicine as doctor orders by remote control [Last Updated On: August 17th, 2024] [Originally Added On: February 16th, 2012]
- Implantable microchip delivers medicine to women with osteoporosis [Last Updated On: August 17th, 2024] [Originally Added On: February 16th, 2012]
- Remote-controlled chip implant delivers bone drug [Last Updated On: August 17th, 2024] [Originally Added On: February 16th, 2012]
- Remote-controlled chip implant delivers meds [Last Updated On: August 17th, 2024] [Originally Added On: February 16th, 2012]
- Remote-control chip implant delivers drug [Last Updated On: August 17th, 2024] [Originally Added On: February 16th, 2012]
- Nano-technology uses virus' coats to fool cancer cells [Last Updated On: August 17th, 2024] [Originally Added On: February 17th, 2012]
- Implanted Chip Delivers Drugs Without a Thought [Last Updated On: August 17th, 2024] [Originally Added On: February 17th, 2012]
- Critical Pharmaceuticals And The University Of Nottingham To Develop Nano-Enabled Nasal Spray For Osteoporosis [Last Updated On: August 17th, 2024] [Originally Added On: February 17th, 2012]
- Nano-enabled nasal spray for osteoporosis [Last Updated On: August 17th, 2024] [Originally Added On: February 18th, 2012]
- One Way Trip to the Moon - Video [Last Updated On: August 17th, 2024] [Originally Added On: February 21st, 2012]
- Remote-control chip delivers drug [Last Updated On: August 17th, 2024] [Originally Added On: February 22nd, 2012]
- Nanomedicine - Part 2 - Video [Last Updated On: August 17th, 2024] [Originally Added On: February 22nd, 2012]
- Nanomedicine - Part 1 - Video [Last Updated On: August 17th, 2024] [Originally Added On: February 22nd, 2012]
- Cost effective and toxix medicine for cancer [Last Updated On: August 17th, 2024] [Originally Added On: February 24th, 2012]
- Nanomedicine Release of neurological drugs - Video [Last Updated On: August 17th, 2024] [Originally Added On: February 24th, 2012]
- 28101 video abstract - Video [Last Updated On: August 17th, 2024] [Originally Added On: February 25th, 2012]
- Allocation for science promotion negligible, says CCMB Director [Last Updated On: August 17th, 2024] [Originally Added On: February 28th, 2012]
- Nano-rockets carrying medicine through body closer to reality [Last Updated On: August 17th, 2024] [Originally Added On: February 29th, 2012]
- Motion in Acid - Video [Last Updated On: August 17th, 2024] [Originally Added On: February 29th, 2012]
- Study: Old flu drug speeds brain injury recovery [Last Updated On: August 17th, 2024] [Originally Added On: March 1st, 2012]
- Flu drug speeds up brain recovery [Last Updated On: August 17th, 2024] [Originally Added On: March 1st, 2012]
- Hometownstations.com-WLIO- Lima, OH News Weather SportsStudy: Old flu drug speeds brain injury recovery [Last Updated On: August 17th, 2024] [Originally Added On: March 1st, 2012]