Contact Information
Available for logged-in reporters only
Newswise Scientists at the Cancer Science Institute of Singapore (CSI Singapore) at the National University of Singapore (NUS) and their collaborators have developed a scoring scheme that predicts the ability of cancer cells to spread to other parts of the body, a process known as metastasis. This system, which is the first of its kind, opens up the possibility to explore new treatments that suppress metastasis in cancer patients. The findings were published in EMBO Molecular Medicine in September.
Led by Professor Jean Paul Thiery, Senior Principal Investigator, and Dr Ruby Huang, Principal Associate, both from CSI Singapore, the scientists developed a scoring scheme which monitors the epithelial-mesenchymal transition (EMT) mechanism. This process was shown to play a role in a large number of cancer-related events, including cancer invasion, metastasis, and chemo-resistance. To date, there are no existing tools to systematically quantify the EMT status of tumours. The newly-developed EMT scoring is thus a promising, versatile tool for investigating EMT roles and dynamics in the progression, treatment response and survival across different types of cancer. It can also be integrated with other molecular tests, such as the detection of mutations of cancer genes, to help identify patients at higher risks for treatment failure and decreased survival.
EMT mechanism and cancer metastasis
Cancer metastasis is responsible for 90 per cent of cancer deaths. One of the mechanisms of metastasis is through the EMT process, where tumour cells lose adhesion contacts with their neighbouring cells at the primary tumour site, and gain the ability to move to a secondary site. The ability to stay in tight contact is an important feature of epithelial cells whereas the ability to gain movement is a characteristic of mesenchymal cells. Tumour cells which undergo the EMT process lose their epithelial features and gain invasive, migratory properties typical of mesenchymal cells.
The EMT mechanism has a varying impact on different populations of cancer cells as they respond differently to the EMT cues. Not every cancer cell will undergo the same degree of loss of cell adhesion ability or gain the ability to move spontaneously, which is known as motility. As a result, tumours from different patients will exhibit a wide range of differences in the status of their EMT. To determine with precision the EMT status of the tumour, the research team developed a quantitative modelling system.
How the EMT scoring scheme was developed
In this study, the researchers utilised a total of 13,000 samples from publicly available databases containing gene expression information for more than 15 different types of cancers. A computational modelling scheme of EMT was established to define tumours having the most epithelial features and tumours having the most mesenchymal features. Subsequently, the tumours were rated on a continuous spectrum of different EMT scores. Tumours with mixed epithelial and mesenchymal features are at the in-between state. This transitional state signifies cancer cell populations that might become truly mesenchymal. Patients who have tumours at this intermediate state may be at higher risks compared to those with tumours at the epithelial state.
The clinical information from the databases, including patient survival and treatment responses, was compared against the EMT scoring scheme. The research team showed that the EMT scoring they developed has a good correlation with previously published, cancer-specific EMT signatures. They used this scoring scheme to establish an EMT spectrum across various cancers and noted good correlation between cancer cell lines and tumours. The scientists concluded that this scoring scheme may enable the objective and systematic investigation of EMT in cancer progression, survival and throughout the clinical response to therapy.
Excerpt from:
- Podcast 9 Athens part 3 and news [Last Updated On: November 8th, 2009] [Originally Added On: November 8th, 2009]
- Podcast 10 Athens part 4 [Last Updated On: November 8th, 2009] [Originally Added On: November 8th, 2009]
- Podcast 11 Athens Part 5 [Last Updated On: November 8th, 2009] [Originally Added On: November 8th, 2009]
- Episode 12 Cardiac Nuclear Medicine in the UK [Last Updated On: November 8th, 2009] [Originally Added On: November 8th, 2009]
- Podcast 13 Choline PET and prostate cancer [Last Updated On: November 8th, 2009] [Originally Added On: November 8th, 2009]
- Episode14 ED function and Dysponea [Last Updated On: November 8th, 2009] [Originally Added On: November 8th, 2009]
- ep 15 Collimator Choice and Reconstruction algorithm [Last Updated On: November 8th, 2009] [Originally Added On: November 8th, 2009]
- Episode 16 Dr Strauss on vulnerable plaque [Last Updated On: November 8th, 2009] [Originally Added On: November 8th, 2009]
- Episode17 Chemical Stress [Last Updated On: November 8th, 2009] [Originally Added On: November 8th, 2009]
- Episode 18 Myocardial Perfusion Imaging and Diabetes [Last Updated On: November 8th, 2009] [Originally Added On: November 8th, 2009]
- Episode 19 The INSPIRE trial [Last Updated On: November 8th, 2009] [Originally Added On: November 8th, 2009]
- 20 Dual isotope with a difference [Last Updated On: November 8th, 2009] [Originally Added On: November 8th, 2009]
- Episode 21 The real effect of stress [Last Updated On: November 8th, 2009] [Originally Added On: November 8th, 2009]
- Episode 22 D-SPECT [Last Updated On: November 8th, 2009] [Originally Added On: November 8th, 2009]
- Episode 23 VQ Reprise [Last Updated On: November 8th, 2009] [Originally Added On: November 8th, 2009]
- Episode 24 Hepatobiliary Nuclear Medicine [Last Updated On: November 8th, 2009] [Originally Added On: November 8th, 2009]
- Episode 25 Sleep Apnea [Last Updated On: November 8th, 2009] [Originally Added On: November 8th, 2009]
- Episode 26 Imaging Post Traumatic Stress Disorder [Last Updated On: November 8th, 2009] [Originally Added On: November 8th, 2009]
- Episode 27 Cardiac Stem Cells [Last Updated On: November 8th, 2009] [Originally Added On: November 8th, 2009]
- Episode 28 Molly Supply [Last Updated On: November 8th, 2009] [Originally Added On: November 8th, 2009]
- Episode 29 Melanoma therapy interview with Dr Ekaterina Dadachova [Last Updated On: November 8th, 2009] [Originally Added On: November 8th, 2009]
- Episode 30 Viral Therapy [Last Updated On: November 8th, 2009] [Originally Added On: November 8th, 2009]
- Episode 31 breast radiotherapy using radioisotopes [Last Updated On: November 8th, 2009] [Originally Added On: November 8th, 2009]
- Episode 32 news from snm [Last Updated On: November 8th, 2009] [Originally Added On: November 8th, 2009]
- Episode 33 EBV Imaging and Therapy [Last Updated On: November 8th, 2009] [Originally Added On: November 8th, 2009]
- Episode 34 Dr Lele SNM India 2009 [Last Updated On: December 14th, 2009] [Originally Added On: December 14th, 2009]
- Episode 35 Dr Andrew Scott from the Ludwig institute [Last Updated On: January 10th, 2010] [Originally Added On: January 10th, 2010]
- Episode 36 CardiArc [Last Updated On: February 25th, 2010] [Originally Added On: February 25th, 2010]
- Episode 37 Dr Modder Radiosynoviorthesis (Radiation Synovectomy) [Last Updated On: March 31st, 2010] [Originally Added On: March 31st, 2010]
- Episode 38 Indian Nuclear Medicine With Dr Malhotra and Dr Krishna [Last Updated On: May 28th, 2010] [Originally Added On: May 28th, 2010]
- Episode 39 Prof Ora Israel The Utility of Hybrid Imaging [Last Updated On: July 13th, 2010] [Originally Added On: July 13th, 2010]
- Episode 40 New V/Q SPECT developments [Last Updated On: October 11th, 2010] [Originally Added On: October 11th, 2010]
- Episode 41 scintimun [Last Updated On: February 14th, 2011] [Originally Added On: February 14th, 2011]
- Episode 42 Radio-Isotope Supply into the future [Last Updated On: March 6th, 2011] [Originally Added On: March 6th, 2011]
- Podcast 4: DNA therapy [Last Updated On: April 24th, 2011] [Originally Added On: April 24th, 2011]
- Sorry about the delay a new podcast will be out soon! [Last Updated On: April 24th, 2011] [Originally Added On: April 24th, 2011]
- Podcast 5 Flash 3D [Last Updated On: April 24th, 2011] [Originally Added On: April 24th, 2011]
- Podcast 6 Affibody [Last Updated On: April 24th, 2011] [Originally Added On: April 24th, 2011]
- Podcast 7 EANM 2006 Athens Part 1 [Last Updated On: April 24th, 2011] [Originally Added On: April 24th, 2011]
- Podcast 8 Athens Part 2 [Last Updated On: April 24th, 2011] [Originally Added On: April 24th, 2011]
- Episode 43 Rapidscan Part 1, 720P high quality video version [Last Updated On: May 1st, 2011] [Originally Added On: May 1st, 2011]
- Episode 43 Rapidscan Part 1, Ipod quality video [Last Updated On: May 1st, 2011] [Originally Added On: May 1st, 2011]
- Episode 43 Rapidscan Part 1, Audio version [Last Updated On: May 1st, 2011] [Originally Added On: May 1st, 2011]
- Episode 45 Mummies with cardiovascular disease video [Last Updated On: May 21st, 2011] [Originally Added On: May 21st, 2011]
- Episode 45 Mummies with cardiovascular disease audio edition [Last Updated On: May 21st, 2011] [Originally Added On: May 21st, 2011]
- Episode 46 Dr Gordon DePuey Choosing Reconstruction clinical perspective [Last Updated On: August 7th, 2011] [Originally Added On: August 7th, 2011]
- Episode 46 Dr Gordon DePuey Choosing Reconstruction clinical perspective audio version [Last Updated On: August 7th, 2011] [Originally Added On: August 7th, 2011]
- Episode 47 Cardiac Image Fusion With Dr Kaufmann [Last Updated On: September 18th, 2011] [Originally Added On: September 18th, 2011]
- Episode 47 Cardiac Fusion with Dr Kaufmann video version [Last Updated On: September 18th, 2011] [Originally Added On: September 18th, 2011]
- Dear Steve, I am and many more like me are your one more thing. [Last Updated On: October 9th, 2011] [Originally Added On: October 9th, 2011]
- EPISODE 48 PET MRI camera from Siemens with Dr Georgi audio [Last Updated On: October 23rd, 2011] [Originally Added On: October 23rd, 2011]
- EPISODE 48 PET MRI camera from Siemens Dr Georgi video [Last Updated On: October 23rd, 2011] [Originally Added On: October 23rd, 2011]
- Silicon Biosystems to Present Single-Circulating Tumor Cell Molecular Characterization at the Fourth World CTC Summit [Last Updated On: April 25th, 2012] [Originally Added On: April 25th, 2012]
- Leukaemia cells have a remembrance of things past [Last Updated On: April 25th, 2012] [Originally Added On: April 25th, 2012]
- Technologist Education Requirements Can Help Cut Repeat Scans [Last Updated On: April 25th, 2012] [Originally Added On: April 25th, 2012]
- HKU Collaborative Research Discovers A Novel Molecular Mechanism Of A New Anti-HIV-1 Drug Candidate [Last Updated On: April 25th, 2012] [Originally Added On: April 25th, 2012]
- Focal Segmental Glomerulosclerosis and the Nephrotic Syndrome - Part 1 Clinical - Video [Last Updated On: May 4th, 2012] [Originally Added On: May 4th, 2012]
- Electro-Medicine : Biological Physics - The Molecular Basis of Alzheimers Disease - Video [Last Updated On: May 4th, 2012] [Originally Added On: May 4th, 2012]
- osdd heterocyclic compounds and molecular medicines - Video [Last Updated On: May 4th, 2012] [Originally Added On: May 4th, 2012]
- Molecule to Medicine: The Biomarker Frontier - Video [Last Updated On: May 4th, 2012] [Originally Added On: May 4th, 2012]
- Fulfilling the Promise of Molecular Medicine in a Developmental Brain Disorder - Video [Last Updated On: May 4th, 2012] [Originally Added On: May 4th, 2012]
- Focus on Stefanie Dimmeler - Video [Last Updated On: May 4th, 2012] [Originally Added On: May 4th, 2012]
- Dundee [Last Updated On: May 4th, 2012] [Originally Added On: May 4th, 2012]
- Nanotechnology In Medicine: Huge Potential, But What Are The Risks? [Last Updated On: May 5th, 2012] [Originally Added On: May 5th, 2012]
- Cutting Edge Technology Coming To DMH [Last Updated On: May 5th, 2012] [Originally Added On: May 5th, 2012]
- This Week in Experimental and Molecular Pathology [Last Updated On: May 5th, 2012] [Originally Added On: May 5th, 2012]
- Researchers' discovery offers hope for cancer, heart disease miracle drugs [Last Updated On: May 7th, 2012] [Originally Added On: May 7th, 2012]
- Penn State student Zachary Hostetler from Garnet Valley is being honored as a student marshal [Last Updated On: May 7th, 2012] [Originally Added On: May 7th, 2012]
- NCKU Student Wins Prestigious Award for Anti-Cancer Research [Last Updated On: May 10th, 2012] [Originally Added On: May 10th, 2012]
- In-Vitro Diagnostics (IVD) Market (Clinical Chemistry, Immunoassays, Molecular Diagnostics, Hematology Analyzers ... [Last Updated On: May 10th, 2012] [Originally Added On: May 10th, 2012]
- Pitt team uses genomics to identify a molecular-based treatment for a viral skin cancer [Last Updated On: May 10th, 2012] [Originally Added On: May 10th, 2012]
- Genomics used to identify a molecular-based treatment for a viral skin cancer [Last Updated On: May 10th, 2012] [Originally Added On: May 10th, 2012]
- 2 molecular biologists get $500K medical prize [Last Updated On: May 13th, 2012] [Originally Added On: May 13th, 2012]
- 2 molecular biologists share $500K medical prize [Last Updated On: May 13th, 2012] [Originally Added On: May 13th, 2012]
- Lab21 Unveils New Molecular Analysis Services at Greenville Site [Last Updated On: May 13th, 2012] [Originally Added On: May 13th, 2012]
- 2 molecular biologists from NYC to share $500K medical prize for pioneering research on cells [Last Updated On: May 13th, 2012] [Originally Added On: May 13th, 2012]
- Two Molecular Biologists Get $500K Medical Prize [Last Updated On: May 13th, 2012] [Originally Added On: May 13th, 2012]
- Pair of molecular biologists receive Albany Medical Center Prize [Last Updated On: May 13th, 2012] [Originally Added On: May 13th, 2012]
- CNIO scientists successfully test the first gene therapy against aging-associated decline [Last Updated On: May 16th, 2012] [Originally Added On: May 16th, 2012]
- Cancer Institute of New Jersey Aims to Advance Personalized Cancer Treatments Through 'Precision Medicine' [Last Updated On: May 16th, 2012] [Originally Added On: May 16th, 2012]