About 50 percent of patients don't take their medicine as prescribed, research shows. And those mistakes are thought to result in at least 100,000 preventable deaths each year. amphotora/Getty Images hide caption

About 50 percent of patients don't take their medicine as prescribed, research shows. And those mistakes are thought to result in at least 100,000 preventable deaths each year.

What if I told you there was a way to use technology to save an estimated $100 billion to $300 billion dollars a year in health care spending in the U.S.? That's the estimated cost incurred because people don't take the medications they're prescribed.

A number of companies are now selling wireless "smart" pill bottles, Internet-linked devices aimed at reminding people to take their pills. But recent research suggests that actually changing that behavior may take more than an electronic nudge.

All agree it's a worthy goal. Dr. Niteesh Choudhry, an internist at Harvard Medical School, describes the problem of not taking medication as "the final cascade of all of science."

Researchers work years, sometimes decades, he says, to develop highly effective drugs, get them approved by the FDA and into the hands of doctors who then study when to prescribe them to sick people. But in order for the drugs to work, they have to be taken.

And up to half the time, they're not taken as prescribed, Choudhry says. The result is at least 100,000 preventable deaths each year.

When you ask patients why they don't take their medicine they usually say they forgot, Choudhry says. So, he recently set out to test some simple reminder devices.

He enrolled 50,000 patients who were taking daily cardiovascular medications or antidepressants in a randomized trial and gave them one of three tools: a pill bottle with toggles to mark whether they'd taken their medication that day; a standard, daily pillbox (with a compartment or compartments for each day); or a digital cap that functions like a stopwatch. It starts counting each time you open it so you can see how long it's been since you last took a pill.

Keeping track of how long it's been since your last pill might be easier with a "TimerCap" on the bottle. But people who used the cap as part of research study weren't any better at taking their medicine as prescribed. Lauren Silverman/KERA hide caption

Keeping track of how long it's been since your last pill might be easier with a "TimerCap" on the bottle. But people who used the cap as part of research study weren't any better at taking their medicine as prescribed.

Choudhry expected a slight improvement in pill-taking among those who used the bottle with the digital cap.

"Unfortunately we found no effect whatsoever," he says, in comparison to adults who used a regular pillbox.

Why not? One of the possible explanations, Choudhry says, is that the device's reminder wasn't powerful enough.

Enter the army of "smart" pill bottles. More than a dozen companies have developed Internet-connected bottles and caps that can send email and text message reminders to take pills, or even alert a caregiver if, say, an elderly parent forgets to take medication. Some such bottles are for sale online others are being handed out by pharmacists.

Thousands of patients, including some with cancer, HIV, and rheumatoid arthritis are turning to a sleek, white, Internet-connected pill bottle made by AdhereTech, says the firm's CEO Josh Stein. He describes his company's wireless device as the iPhone of pill bottles.

An Adhere Tech "smart" pill bottle emits a blue glow when it's time to take a pill, and flashes red if you've missed a dose. Adhere Tech hide caption

An Adhere Tech "smart" pill bottle emits a blue glow when it's time to take a pill, and flashes red if you've missed a dose.

"Our system is automatically getting data sent from each and every bottle 24/7," Stein says. (So far the devices are only being distributed on an experimental basis, via certain pharmacies and drug companies.)

Sensors in the bottle detect when the cap is twisted off and how much medication is removed. When it's time to take a pill, a blue reminder light pulses. Miss a dose? A red light flashes, then a chime goes off, and then the patient or a caregiver gets a phone call or text message.

"Other devices will require patients to set up a device, or download apps and integrate everything," Stein says. "We work with an average patient population that's 70 years old. A lot of those patients don't have Bluetooth or Wi-Fi, so we need something that works right out of the box."

One downside: The AdhereTech system is expensive to produce and to maintain the software. Stein won't say exactly how costly or how much the company would likely charge consumers ultimately but he compares it to the cost of a basic cell phone, plus monthly fees.

Just how well do these fancier pill bottles work? Stein says that AdhereTech was able to increase patients' adherence to their medication regimen by an average of 24 percent in a small, pilot study.

But a large-scale evaluation of smart-bottle technology, published online in the journal JAMA Internal Medicine last month, showed results that were far less encouraging.

Dr. Kevin Volpp, a physician and health economist who directs the University of Pennsylvania's Center for Health Incentives, studied more than a thousand patients with heart failure who were each given the GlowCap pill bottle, an Internet-linked device made by firm Vitality. In addition to the high-tech pill bottles, the people in the study received a cash reward if they took their medicine on time, and were given the option of having the bottle alert someone if they skipped a dose.

"The expectation was that we would see a large increase in medication adherence and that would then translate into a significant reduction in hospital readmissions and lower healthcare costs," Volpp says.

But that's not what happened.

Even with the glowing pill bottle, the cash and the alert, many people didn't take their meds.

Let's recap here: We've looked at two large studies of pill bottle reminder systems. One was pretty basic and the other, higher-tech. Neither one seemed to help patients stay on top of their medication.

What's going on? Volpp and says it could be a problem with the study's design, or with the devices. Or maybe, just maybe, the main problem isn't forgetfulness.

"Patients in many cases don't like taking medicines every day," Volpp points out. "It reminds them of the illness and they'd rather not be reminded of that."

Any medication can have negative side effects and some cost a lot, he says. Using a smart pill bottles won't make the drug cheaper or get rid of nasty side effects like impotence or severe fatigue.

Still Volpp remains optimistic about pill bottle technology he just thinks the high-tech strategy needs to be paired with social interventions. In his study the results were better for patients who had their pill bottle automatically alert a friend if they missed a dose.

Choudhry agrees that although "reminder technology" is bound to be part of the solution especially for people with memory issues it won't be enough to change everyone's behavior.

When it comes to getting people to take their medications, it looks like a smart bottle is no magic pill.

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'Smart' Pill Bottles Aren't Enough To Help The Medicine Go Down - NPR