Harvard Clinical and Translational Science Center Medicine Lee Marshall Nadler $21,900,459 Integrated discovery and development of innovative TB Diagnostics Global Health and Social Medicine Megan B Murray $5,956,642 Innovative Platforms for Antimicrobial Therapy and Vaccine Development Microbiology and Immunobiology Dennis L. Kasper $4,937,887 Small molecule inhibitors of enveloped virus entry Microbiology and Immunobiology Sean P. J. Whelan $4,422,325 Harvard University Center for AIDS Research Medicine Bruce D Walker $4,278,137 Causal Transcriptional Consequences of Human Genetic Variation Genetics George M Church $3,581,194 Neuropsychiatric Genome-Scale and RDOC Individualized Domains (N-GRID) Center for Biomedical Informatics Isaac S. Kohane $3,375,284 The HMS Laboratory of Systems Pharmacology Systems Biology Peter Karl Sorger $2,346,106 T Cell Costimulatory Pathways: Functions and Interactions Microbiology and Immunobiology Arlene H. Sharpe $2,194,909 Pharmaco Response Signatures and Disease Mechanism Systems Biology Peter Karl Sorger $2,145,458 Genome Engineering an IPSC Model of Alzheimer's Disease Genetics Bruce A Yankner $2,095,914 Patient-Centered Information Commons Center for Biomedical Informatics Isaac S. Kohane $2,082,841 Membrane protein structures by solution NMR Biological Chemistry and Molecular Pharmacology James J Chou $2,067,250 Medical Scientists Training Program Neurology Loren David Walensky $2,005,360 NMR and Computational Studies of Biomolecules Biological Chemistry and Molecular Pharmacology Gerhard Wagner $2,000,194 Mechanisms and Immunological Consequences of Host-Virus Interactions Microbiology and Immunobiology Ulrich H Von Andrian $1,972,162 Mapping Transcriptional Networks in Cardiac Development Medicine Jonathan G Seidman $1,855,538 Harvard Clinical and Translational Science Center Medicine Lee Marshall Nadler $1,738,300 Mechanistic Pharmacology of Anti-Mitotics and Apoptosis Regulation Inst for Chemistry & Cell Biology Timothy J Mitchison $1,737,021 Viral And host mechanisms that tilt the HSV lytic/latent balance Biological Chemistry and Molecular Pharmacology Donald M Coen $1,732,800 Coordinating Center for the Undiagnosed Diseases Network Center for Biomedical Informatics Isaac S. Kohane $1,498,448 ImmGen: gene expression and regulation in immune cells Microbiology and Immunobiology Christophe O Benoist $1,436,676 Developmental Regulation of Bone Morphogenesis Genetics Clifford J Tabin $1,388,239 Genetic Modeling for SMA Therapeutic Pathways Cell Biology David L. Van Vactor $1,250,388 Atomic Resolution in Biological Electron Microscopy Biological Chemistry and Molecular Pharmacology Stephen Coplan Harrison $1,195,537 Human Cardio-Pulmonary System on a Chip Wyss Institute Kevin Kit Parker $1,154,347 Boston-Area Research Training Program in Biomedical Informatics Medicine Alexa T. Mccray $1,076,604 Biochemical Studies of Mitosis Systems Biology Marc Wallace Kirschner $946,577 Coordinating Center for the Undiagnosed Diseases Network Center for Biomedical Informatics Isaac S. Kohane $943,589 Targeting a Novel Regulator of Brain Aging and Alzheimer's Disease Genetics Bruce A Yankner $935,613 Novel therapeutic agents from the bacterial symbionts of Brazilian invertebrates Biological Chemistry and Molecular Pharmacology Jon Clardy $907,024 Training for Speech and Hearing Sciences Otolaryngology Bertrand Delgutte $893,045 Mechanisms of yeast transcriptional initiation Biological Chemistry and Molecular Pharmacology Kevin Struhl $877,330 Identifying and validating new antibiotic targets in cell wall synthesis pathways Microbiology and Immunobiology Thomas G Bernhardt $858,826 Single cell analysis of metabolism using genetically-encoded fluorescent sensors Neurobiology Gary I Yellen $847,500 The inheritance of position: It's not just who you are, it's where you are Genetics Chao-Ting Wu $847,500 New tools for understanding the blood brain barrier Neurobiology Chenghua Gu $847,500 CORE GRANT FOR VISION RESEARCH Neurobiology Margaret S Livingstone $841,865 Modeling the Aging Epigenome Pathology Bruce A Yankner $839,025 Large-Scale High-Confidence Binary Protein Interaction Network for Drosophila Genetics Norbert Perrimon $837,691 Generation and Function of NK Cell Memory Microbiology and Immunobiology Ulrich H Von Andrian $834,830 NKT cells as modulators of AIDS vaccine efficacy New England Primate Research Center Amitinder Kaur $824,896 Systematic Exploration of the Human Interactome Cell Biology Steven P Gygi $809,660 Drosophila Transgenic RNAi Resource Project Genetics Norbert Perrimon $791,836 Functional Genomic Analysis by RNAi Screening in Drosophila Cells Genetics Norbert Perrimon $781,693 HMS/CHB Center for Neuroscience Research Neurobiology Michael E Greenberg $766,358 Functional Coupling of Steps in Genes Expression Cell Biology Robin E Reed $741,644 Mechanism and inhibition of SREBP-dependent cholesterol/lipid metabolism Biological Chemistry and Molecular Pharmacology Gerhard Wagner $720,423 Substance Use Disorder Treatment under New Payment and Delivery System Models Health Care Policy Haiden A. Huskamp $717,215 Genetic Analysis of Toxinogenesis in Vibrio Cholerae Microbiology and Immunobiology John Joseph Mekalanos $715,353 Microbial Diversity in Mechanisms of Disulfide Bond Formation and Reduction Microbiology and Immunobiology Dana Boyd $709,142 Genomic targets of oncoproteins and tumor suppressors Biological Chemistry and Molecular Pharmacology Kevin Struhl $677,486 Poliovirus Cell Entry Pathways Biological Chemistry and Molecular Pharmacology James M Hogle $676,899 Social Networks and the Spread of Cancer Care Practices Health Care Policy Bruce E. Landon $672,238 Cytotoxic T Cell Mediated Immunity to Chlamydia Microbiology and Immunobiology Michael N Starnbach $660,708 Super-resolution imaging via programmable autonomous blinking Systems Biology Peng Yin $650,220 Human Cytomegalovirus Nuclear Egress: Molecular Mechanisms and Drug Targeting Biological Chemistry and Molecular Pharmacology Donald M Coen $647,245 Developmental gene networks of 5HT neurons in addiction, aggression, and anxiety Genetics Susan M. Dymecki $637,552 PHD TRAINING IN NEUROSCIENCE Neurobiology Rosalind A. Segal $633,137 Cellular and Developmental Biology Cell Biology Jeffrey W Harper $631,877 Molecular Biophysics Training Grant Biological Chemistry and Molecular Pharmacology James M Hogle $631,877 Protein/Protein Interactions in Prokaryotic Gene Control Microbiology and Immunobiology Ann Hochschild $626,078 Signal Transduction to P70 S6 Kinase 1 Cell Biology John Blenis $618,013 Neurotrophic Factor Regulation of Gene Expression Neurobiology Michael E Greenberg $615,631 Mental Health Coverage and Payment in Private Health Plans Health Care Policy Thomas G. Mcguire $615,584 Systems analysis of cell type differentiation in xenopus development Systems Biology Marc Wallace Kirschner $611,915 Harvard Clinical and Translational Science Center Medicine Lee Marshall Nadler $611,464 Molecular Basis of Viral Infectivity Microbiology and Immunobiology David M Knipe $602,779 COPD and Response to Traffic Related Particles None Eric Garshick $602,341 Electrical Stimulation of Immediate Early Genes Neurobiology Michael E Greenberg $601,630 The NEPRC SPF Rhesus Macaque Breeding Colony New England Primate Research Center Roger D Spealman $592,204 The algorithms used by the genome to interpret neural activity Genetics Jesse Michael Gray $583,946 Microtubule Dynamics and Mitotic Mechanism Systems Biology Timothy J Mitchison $574,473 Technology Diffusion and New Delivery Models Health Care Policy Sharon-Lise Teresa Normand $565,542 Synaptic Basis of Sleep Cycle Control Psychiatry Robert W Mccarley $564,262 mRNA Capping Enzyme Biological Chemistry and Molecular Pharmacology Stephen Buratowski $559,511 Hedgehog Signaling and Organogenesis of the Limb Genetics Clifford J Tabin $553,611 Short-Term Synaptic Plasticity in the CNS Neurobiology Wade G Regehr $550,312 Measuring and Improving Colonoscopy Quality Using Natural Language Processing Medicine Ateev Mehrotra $547,410 Training in the Molecular Biology of Neurodegeneration Pathology Bruce A Yankner $542,073 Coordinate Regulation of Bacterial Virulence Factors Microbiology and Immunobiology John Joseph Mekalanos $538,137 Mechanism and Inhibition of Bacterial Transglycosylases and Transpeptidases. Microbiology and Immunobiology Suzanne Walker $533,887 Role of TBK1 polyubiquitination in innate antiviral immunity Pathology Martin E Dorf $531,662 HIV cure studies: risk, risk perception, and ethics Global Health and Social Medicine Nir Eyal $527,747 Cell Cycle Regulation Systems Biology Marc Wallace Kirschner $522,574 Explaining Variations in End-of-Life Care Intensity Health Care Policy Nancy L Keating $522,276 Factors Controlling Transcription and Chromatin in Yeast Genetics Fred M. Winston $518,647 Reverse Correlation Mapping in Face Patches Neurobiology Margaret S Livingstone $518,151 Structure, Function and Inhibition of Human O-GlcNAc Transferase Microbiology and Immunobiology Suzanne Walker $517,469 Optimizing Delivery of ART/PrEP for HIV Prevention through Qualitative Research Global Health and Social Medicine Norma C Ware $515,132 Molecular Chaperones and Protein Degradation Cell Biology Alfred L Goldberg $513,588 Molecular Genetics of HSV DNA Polymerase Gene Biological Chemistry and Molecular Pharmacology Donald M Coen $508,297 Function and mechanism of the HCV p7 channel and its therapeutic potential Biological Chemistry and Molecular Pharmacology James J Chou $507,639 Molecular and biochemical basis of Lymphangioleiomyomatosis Cell Biology John Blenis $498,075 Cell Cycle proteomicsin Xenopus Systems Biology Marc Wallace Kirschner $496,754 International Herpes Vaccine Project Microbiology and Immunobiology David M Knipe $496,204 Global characterization of ubiquitin information networks with mass spectrometry Cell Biology Steven P Gygi $494,852 Multi-allelic copy number variation of the human genome Genetics Steven Andrew Mccarroll $490,000 Protein Transport Across Membranes Cell Biology Tom A Rapoport $488,906 Regulation of Cytoplasmic Dynein Cell Biology Samara L Reck-Peterson $486,581 Influences on Psychiatrist Prescribing of Antipsychotics Health Care Policy Haiden A. Huskamp $483,585 Network analysis of Signal Transduction Genetics Norbert Perrimon $479,107 Estimating the Potential Medicare Savings from Comparative Effectiveness Research Health Care Policy Alan Garber $477,517 T Cell Activation in Lymph Nodes Pathology Ulrich H Von Andrian $471,776 Cell-Cell Signaling in Development and Regeneration of Visual Connections Cell Biology John G Flanagan $455,916 Action and interaction of ionotropic and metabotropic neurotransmission Neurobiology Bernardo L Sabatini $449,762 Polymeric Matrices with Defined Cell Adhesion Wyss Institute David J Mooney $447,810 Voltage-Dependent Ion Channels Controlling Firing Patterns of Central Neurons Neurobiology Bruce P Bean $446,948 Lineage and cell migration in patterning the limb primordium Genetics Clifford J Tabin $446,205 Nuclear Sensing of Herpesviral DNA Microbiology and Immunobiology David M Knipe $443,487 Ubiquitin chain editing by the mammalian proteasome Cell Biology Daniel J Finley $441,222 Development of Validated Drosophila in vivo RNAi Models of Human Diseases Genetics Norbert Perrimon $436,690 Alcohol and Cell Adhesion Neurology Michael Edward Charness $434,948 Neuronal Epigenomic Changes in Neurodevelopment and Disease Neurobiology Michael E Greenberg $424,348 Gut microbiome influences on autoimmune disease Microbiology and Immunobiology Christophe O Benoist $423,750 Physician Determinants of Health Care Spending, Quality, and Patient Outcomes Health Care Policy Anupam Bapu Jena $423,750 The molecular mechanism of Aire: partnering with DNA-PK Pathology Diane J Mathis $423,750 Molecular Genetics of Biofilm Formation Microbiology and Immunobiology Roberto G. Kolter $423,750 In vivo role of CTLA-4 in Costimulation and Autoimmunity None Arlene H. Sharpe $423,750 Genetic Signals in Ventricular Hypertrophy Genetics Jonathan G Seidman $423,750 Naive T cell homeostasis: Treg selection and survival Microbiology and Immunobiology Christophe O Benoist $423,750 Peptide Modulation of Striatal Patch and Matrix Subdivisions Neurobiology Bernardo L Sabatini $421,665 In Vivo Function of the B7 Family of Costimulators Pathology Arlene H. Sharpe $421,665 Chemical Tools for the Study of Dengue Virus Entry Microbiology and Immunobiology Priscilla Li-Ning Yang $421,606 SIRT1 as a regulator of health and lifespan of mammals Genetics David A. Sinclair $421,158 Fundamental Neurobiology Neurobiology Wade G Regehr $420,567 Neuronal Activity-Dependent Regulation of MeCP2 Neurobiology Michael E Greenberg $420,478 P. aeruginosa Virulence Determinants Microbiology and Immunobiology Stephen Lory $419,513 Scalable Assays for Morphological Analysis of Mammalian Neurons Neurobiology Bernardo L Sabatini $419,513 Systematic discovery and functional analysis of the PARKIN modified proteome Cell Biology Jeffrey W Harper $419,513 Chemical biology of bacterial symbionts Biological Chemistry and Molecular Pharmacology Jon Clardy $415,317 Integrin-Based Mechanisms in Terminal Erythroid Maturation Biological Chemistry and Molecular Pharmacology David E. Golan $415,275 Mechanisms of Transcriptional Control Revealed by Nascent Transcript Sequencing Genetics Lee Stirling Churchman $415,275 Defining Genetic Architecture and Pathways of DCM Genetics Jonathan G Seidman $415,275 Cortico-Cortical Feedback Neurobiology Richard T Born $415,275 Gene therapy to support cone metabolism in retinitis pigmentosa Genetics Constance L Cepko $415,275 Peptidoglycan Biogenesis in Escherichia Coli Microbiology and Immunobiology Thomas G Bernhardt $413,398 Molecular Mechanisms of Rhabdovirus Entry Microbiology and Immunobiology Sean P. J. Whelan $413,330 RNA Processing in Non-Segmented Minus-Strand RNA Viruses Microbiology and Immunobiology Sean P. J. Whelan $413,302 INTERNAL SIGNALS IN THE PARIETAL VISUAL PATHWAY Neurobiology John Assad $411,470 Epigenetic Regulation of HSV Infection of Oral Cells Microbiology and Immunobiology David M Knipe $411,038 Enhancing Diversity in Academic Medicine through Faculty Networks None Joan Y. Reede $410,276 Accurate analysis of genome structural variation using large-scale sequence data Genetics Steven Andrew Mccarroll $408,509 In toto imaging and genomics to decode ear hair cell formation and regeneration Systems Biology Sean G Megason $408,254 Signal transduction in axon guidance Cell Biology John G Flanagan $398,423 Chemical Biology of Microbial Interspecies Signaling Microbiology and Immunobiology Roberto G. Kolter $398,325 Analysis of Intratumoral Crosstalk in Clonal Populations of OvarianTumor Cells Cell Biology Joan Siefert Brugge $398,239 BMAL1 Complexes of the Circadian Clock Neurobiology Charles J Weitz $397,423 Healthy Options: Group psychotherapy for HIV-positive depressed perinatal women Global Health and Social Medicine Mary Catherine Smith Fawzi $397,062 Membrane Remodeling and Protein Trafficking in Bacteria Microbiology and Immunobiology David Z Rudner $396,630 Factors Mediating Host Resistance to Chlamydia trachomatis Microbiology and Immunobiology Michael N Starnbach $395,675 The RNA polymerase II transcription complex Biological Chemistry and Molecular Pharmacology Stephen Buratowski $395,264 Neuroimaging and Neuropsychological Biomarkers of Vascular Risk Factors None Elizabeth C Leritz $395,219 Modeling individual-to-collective behavior in mound-building termites Wyss Institute Justin K Werfel $390,718 Ubiquitin-mediated proteolysis and cell cycle control Cell Biology Jeffrey W Harper $389,947 Characterization of the Insulin to Autophagy Pathway in Muscles Genetics Norbert Perrimon $389,806 Chemical Genetic and Biochemical Studies of Mitotic Proteolysis Cell Biology Randall W King $389,776 Regulation of Host Innate Immunity Against Viral Infection New England Primate Research Center Michaela Ulrike Gack $386,471 Functional genetic evolution of human brain and behavior New England Primate Research Center Eric J. Vallender $384,191 Long-term effects of botulinum neurotoxins on neuronal viability New England Primate Research Center Min Dong $378,985 Adipose-issue Tregs: Important Players In The Immunological Control Of Metabolis Pathology Diane J Mathis $375,443 Structure and function in Notch Signaling Biological Chemistry and Molecular Pharmacology Stephen C. Blacklow $373,771 Molecular Dissection of Active Zone Functions in Neurotransmitter Release Neurobiology Pascal Simon Kaeser $370,781 Visual Processing in the Cerebral Cortex Neurobiology John Hr Maunsell $370,415 Aire, a zinc-finger protein that controls autoimmunity Pathology Diane J Mathis $368,663 Development of novel transsynaptic tracers for use in the central nervous system Genetics Constance L Cepko $367,074 Neurotrophin signals controlling development of the peripheral nervous system Neurobiology David D Ginty $367,074 Investigating the mechanism of TNFalpha mediated cell death in oligodendrocytes Cell Biology Junying Yuan $367,074 Cellular mechanisms of dietary therapy for epilepsy Neurobiology Gary I Yellen $367,074 Biomaterial based breast cancer vaccine Wyss Institute David J Mooney $366,115 The translation apparatus of Leishmania: from basic analysis to pursuit of novel Biological Chemistry and Molecular Pharmacology Gerhard Wagner $366,095 Novel mechanisms for oxysterols in cell-cell signaling Cell Biology Adrian Salic $365,637 Training in Pharmacological Sciences Biological Chemistry and Molecular Pharmacology David E. Golan $361,073 Olfactory?circuits?that?control?behavior Cell Biology Stephen Daniel Liberles $360,188 Role of GATA6 in regulating hedgehog signaling in the growth plate Biological Chemistry and Molecular Pharmacology Andrew Bruce Lassar $360,188 Molecular Basis of Inherited Deafness Neurobiology David P Corey $359,847 Regulation of Synapse Morphogenesis in Drosophila Cell Biology David L. Van Vactor $359,732 The Role of Semaphorins in Axon and Blood Vessel Guidance Neurobiology Chenghua Gu $359,732 Identification of the transcriptional regulators of chondrocyte hypertrophy Biological Chemistry and Molecular Pharmacology Andrew Bruce Lassar $358,798 Chromosome Dynamics in Bacillus Subtills Microbiology and Immunobiology David Z Rudner $356,586 Characterizing Odor Maps in the Olfactory Bulb and Cortex Neurobiology Sandeep R Datta $354,979 RNAi-Mediated Heterochromatin Assembly Cell Biology Danesh Moazed $351,713 Dopaminergic Enabling of Synaptic Plasticity in Prefrontal Circuits New England Primate Research Center Wei-Dong Yao $350,000 Synaptic and circuit mechanisms of olfactory processing Neurobiology Rachel Wilson $349,635 Phages and Genomic Variation in Vibrio Cholerae Evolution Microbiology and Immunobiology John Joseph Mekalanos $348,870 Molecular Mechanisms of Auditory Transduction Neurobiology David P Corey $348,662 Cellular and Molecular Mechanisms of Ear Morphogenesis Neurobiology Lisa V Goodrich $348,662 Investigating the neuroinflammatory role of RIP1 kinase Cell Biology Junying Yuan $347,475 How do Amine Neurons Work? Neurobiology Edward A Kravitz $346,097 Structural and Mechanistic Studies of Regulation of let-7 biogenesis by Lin28' Biological Chemistry and Molecular Pharmacology Piotr Sliz $341,161 Molecular Genetics of the Bithorax Complex Biological Chemistry and Molecular Pharmacology Welcome Bender $339,424 Hormonal Modulation of Aggression in Drosophila Neurobiology Edward A Kravitz $339,000 Structural Basis of Immune Cell Receptor Function Biological Chemistry and Molecular Pharmacology Gerhard Wagner $335,197 Minority Physicians and Research Careers: Applying the Theory of Planned Behavior None Edward Krupat $331,251 Genomic Functions of Nucleosome Dynamics Biological Chemistry and Molecular Pharmacology Kamran Ahmad $330,525 The population genetics of antibiotic resistance in multi-drug environments Systems Biology Roy Kishony $330,051 The variability of the lifespan phenotype in C.elegans Systems Biology Walter Fontana $326,857 Designing Biological Circuits Systems Biology Pamela A Silver $325,732 Development and architecture of epigenetic regulatory elements Biological Chemistry and Molecular Pharmacology Kamran Ahmad $322,050 Mechanism of Action of Yeast Silencing Complexes Cell Biology Danesh Moazed $322,050

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