New research at Children’s Hospital Boston and the Immune Disease Institute (IDI) helps explain common cancer mutations caused by DNA chromosomes breaking and fusing back together at the wrong spots to connect two different genes. These chromosomal rearrangements are characteristic of many types of cancers, including leukemias and lymphomas. In work that was published in the February 16 issue of Cell, Dr. Frederick Alt at the Children’s Hospital Boston and Dr. Job Dekker at the University of Massachusetts Medical School have worked out some of the rules about how these rearrangements occur.
The study combined two distinct technologies that each lab developed over the past several years. One technique developed by Dr. Alt’s group that uses high-throughput DNA sequencing to find where chro…

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