Short bursts of physical exercise induce changes in the bodys levels of metabolites that correlate to an individuals cardiometabolic, cardiovascular, and long-term health, a study by Harvard-affiliated Massachusetts General Hospital (MGH) has found.
In a paper published inCirculation, the research team describes how about 12 minutes of acute cardiopulmonary exercise affected more than 80 percent of circulating metabolites, including pathways linked to a wide range of favorable health outcomes, thus identifying potential mechanisms that could contribute to a better understanding of cardiometabolic benefits of exercise.
What was striking to us was the effects a brief bout of exercise can have on the circulating levels of metabolites that govern such key bodily functions as insulin resistance, oxidative stress, vascular reactivity, inflammation, and longevity, said investigator Gregory Lewis, section head of Heart Failure at MGH and senior author of the study.
The MGH study drew on data from the Framingham Heart Study to measure the levels of 588 circulating metabolites before and immediately after 12 minutes of vigorous exercise in 411 middle-aged men and women.
The research team detected favorable shifts in a number of metabolites for which resting levels were previously shown to be associated with cardiometabolic disease. For example, glutamate, a key metabolite linked to heart disease, diabetes, and decreased longevity, fell by 29 percent. And DMGV, a metabolite associated with increased risk of diabetes and liver disease, dropped by 18 percent. The study further found that metabolic responses may be modulated by factors other than exercise, including a persons sex and body mass index, with obesity possibly conferring partial resistance to the benefits of exercise.
Intriguingly, our study found that different metabolites tracked with different physiologic responses to exercise, and might therefore provide unique signatures in the bloodstream that reveal if a person is physically fit, much the way current blood tests determine how well the kidney and liver are functioning, notes co-first author Matthew Nayor of the Heart Failure and Transplantation Section in the Division of Cardiology at MGH. Lower levels of DMGV, for example, could signify higher levels of fitness.
The Framingham Heart Study, which began in 1948 and now embraces three generations of participants, allowed MGH researchers to apply the same signatures used in the current study population to stored blood from earlier generations of participants. By studying the long-term effects of metabolic signatures of exercise responses, researchers were able to predict the future state of an individuals health, and how long they are likely to live.
Were starting to better understand the molecular underpinnings of how exercise affects the body and use that knowledge to understand the metabolic architecture around exercise response patterns, says co-first author Ravi Shah of the Heart Failure and Transplantation Section in the Division of Cardiology at MGH. This approach has the potential to target people who have high blood pressure or many other metabolic risk factors in response to exercise, and set them on a healthier trajectory early in their lives.
Lewis is associate professor of medicine at Harvard Medical School and director of the Cardiopulmonary Exercise Testing Laboratory at MGH. Nayor is a cardiologist at MGH and instructor of medicine at Harvard Medical School, and Shah is a cardiologist at MGH and assistant professor of medicine at Harvard Medical School. Other co-authors include Ramachandran Vasan, professor of medicine at Boston University and principal investigator of the Framingham Heart Study, and Clary Clish, senior director of Metabolomics at the Broad Institute of MIT and Harvard.
The study was supported by the American Heart Associations Grand Challenge Award and the National Institutes of Health.
Read the original post:
12-minute bursts of exercise have bigger impact than thought - Harvard Gazette
- Vitamin K Delivers Kick to Cancer Risk [Last Updated On: August 17th, 2024] [Originally Added On: April 7th, 2010]
- Magnesium for Memory [Last Updated On: August 17th, 2024] [Originally Added On: April 7th, 2010]
- The Long Road Towards Prosthetic Nerves [Last Updated On: August 17th, 2024] [Originally Added On: April 9th, 2010]
- More on DAF-16 and Longevity in Nematodes [Last Updated On: August 17th, 2024] [Originally Added On: April 9th, 2010]
- Rapamycin and Alzheimer's Disease [Last Updated On: August 17th, 2024] [Originally Added On: April 9th, 2010]
- Rapamycin and Alzheimer's Disease [Last Updated On: August 17th, 2024] [Originally Added On: April 9th, 2010]
- Better Understanding Cytomegalovirus [Last Updated On: August 17th, 2024] [Originally Added On: April 9th, 2010]
- On Mitophagy and Aging [Last Updated On: August 17th, 2024] [Originally Added On: April 9th, 2010]
- A Trial of Giving Stem Cells Orders [Last Updated On: August 17th, 2024] [Originally Added On: April 9th, 2010]
- Methuselah Foundation Launches NewOrgan Prize [Last Updated On: August 17th, 2024] [Originally Added On: April 9th, 2010]
- The Contributions of Mitochondria to Longevity [Last Updated On: August 17th, 2024] [Originally Added On: April 9th, 2010]
- Dual Action Antibodies Versus Cancer [Last Updated On: August 17th, 2024] [Originally Added On: April 9th, 2010]
- Longevity and the End of Empire [Last Updated On: August 17th, 2024] [Originally Added On: April 9th, 2010]
- The Long Road Towards Prosthetic Nerves [Last Updated On: August 17th, 2024] [Originally Added On: April 10th, 2010]
- More on DAF-16 and Longevity in Nematodes [Last Updated On: August 17th, 2024] [Originally Added On: April 10th, 2010]
- Rapamycin and Alzheimer’s Disease [Last Updated On: August 17th, 2024] [Originally Added On: April 10th, 2010]
- Better Understanding Cytomegalovirus [Last Updated On: August 17th, 2024] [Originally Added On: April 10th, 2010]
- On Mitophagy and Aging [Last Updated On: August 17th, 2024] [Originally Added On: April 10th, 2010]
- A Trial of Giving Stem Cells Orders [Last Updated On: August 17th, 2024] [Originally Added On: April 10th, 2010]
- Methuselah Foundation Launches NewOrgan Prize [Last Updated On: August 17th, 2024] [Originally Added On: April 10th, 2010]
- The Contributions of Mitochondria to Longevity [Last Updated On: August 17th, 2024] [Originally Added On: April 10th, 2010]
- Dual Action Antibodies Versus Cancer [Last Updated On: August 17th, 2024] [Originally Added On: April 10th, 2010]
- Longevity and the End of Empire [Last Updated On: August 17th, 2024] [Originally Added On: April 10th, 2010]
- Longevity Meme Newsletter, April 12 2010 [Last Updated On: August 17th, 2024] [Originally Added On: April 12th, 2010]
- Printing New Tissue Directly Onto the Body [Last Updated On: August 17th, 2024] [Originally Added On: April 12th, 2010]
- Reprogramming Autoimmune Disease [Last Updated On: August 17th, 2024] [Originally Added On: April 12th, 2010]
- Diet and Exercise Can Override the Genetic Disposition towards Obesity [Last Updated On: August 17th, 2024] [Originally Added On: April 12th, 2010]
- Your Heart Truly Loves Chocolate! [Last Updated On: August 17th, 2024] [Originally Added On: April 12th, 2010]
- CSC news roundup 2010-04-11 [Last Updated On: August 17th, 2024] [Originally Added On: April 13th, 2010]
- Longevity Meme Newsletter, April 12 2010 [Last Updated On: August 17th, 2024] [Originally Added On: April 13th, 2010]
- Printing New Tissue Directly Onto the Body [Last Updated On: August 17th, 2024] [Originally Added On: April 13th, 2010]
- Reprogramming Autoimmune Disease [Last Updated On: August 17th, 2024] [Originally Added On: April 13th, 2010]
- Diet and Exercise Can Override the Genetic Disposition towards Obesity [Last Updated On: August 17th, 2024] [Originally Added On: April 13th, 2010]
- Your Heart Truly Loves Chocolate! [Last Updated On: August 17th, 2024] [Originally Added On: April 13th, 2010]
- Trialing Stem Cells to Heal Heart Damage [Last Updated On: August 17th, 2024] [Originally Added On: April 13th, 2010]
- Selection Effects and Longevity Genes [Last Updated On: August 17th, 2024] [Originally Added On: April 13th, 2010]
- How Exercise Can Awaken Your Creative Genius Within [Last Updated On: August 17th, 2024] [Originally Added On: April 13th, 2010]
- Trialing Stem Cells to Heal Heart Damage [Last Updated On: August 17th, 2024] [Originally Added On: April 14th, 2010]
- Selection Effects and Longevity Genes [Last Updated On: August 17th, 2024] [Originally Added On: April 14th, 2010]
- How Exercise Can Awaken Your Creative Genius Within [Last Updated On: August 17th, 2024] [Originally Added On: April 14th, 2010]
- WILT, ALT, and Zscan4 [Last Updated On: August 17th, 2024] [Originally Added On: April 14th, 2010]
- Damage in Early Life Shortens Life Expectancy [Last Updated On: August 17th, 2024] [Originally Added On: April 14th, 2010]
- WILT, ALT, and Zscan4 [Last Updated On: August 17th, 2024] [Originally Added On: April 15th, 2010]
- Damage in Early Life Shortens Life Expectancy [Last Updated On: August 17th, 2024] [Originally Added On: April 15th, 2010]
- Synthetic Biology and the Extracellular Matrix [Last Updated On: August 17th, 2024] [Originally Added On: April 15th, 2010]
- The Tithonus Error as Prospection Error [Last Updated On: August 17th, 2024] [Originally Added On: April 15th, 2010]
- F.D.A. Says Millions Got Unapproved Drugs, Should the new bioequivalence and bioanalytical guidelines for 2010, be made more stringent [Last Updated On: August 17th, 2024] [Originally Added On: April 16th, 2010]
- Synthetic Biology and the Extracellular Matrix [Last Updated On: August 17th, 2024] [Originally Added On: April 16th, 2010]
- The Tithonus Error as Prospection Error [Last Updated On: August 17th, 2024] [Originally Added On: April 16th, 2010]
- Towards an Artificial Pancreas [Last Updated On: August 17th, 2024] [Originally Added On: April 16th, 2010]
- Immortality Isn't Unethical [Last Updated On: August 17th, 2024] [Originally Added On: April 16th, 2010]
- Immortality Isn't Unethical [Last Updated On: August 17th, 2024] [Originally Added On: April 16th, 2010]
- Alcohol in Adolescence: A Cancerous Combination? [Last Updated On: August 17th, 2024] [Originally Added On: April 16th, 2010]
- Green Tea for Weight Loss [Last Updated On: August 17th, 2024] [Originally Added On: April 16th, 2010]
- Towards an Artificial Pancreas [Last Updated On: August 17th, 2024] [Originally Added On: April 17th, 2010]
- Immortality Isn’t Unethical [Last Updated On: August 17th, 2024] [Originally Added On: April 17th, 2010]
- Alcohol in Adolescence: A Cancerous Combination? [Last Updated On: August 17th, 2024] [Originally Added On: April 17th, 2010]
- Green Tea for Weight Loss [Last Updated On: August 17th, 2024] [Originally Added On: April 17th, 2010]
- On Calorie Restriction Research [Last Updated On: August 17th, 2024] [Originally Added On: April 17th, 2010]
- AGE Precursor Methylglyoxal Also an Issue? [Last Updated On: August 17th, 2024] [Originally Added On: April 17th, 2010]
- On Calorie Restriction Research [Last Updated On: August 17th, 2024] [Originally Added On: April 18th, 2010]
- AGE Precursor Methylglyoxal Also an Issue? [Last Updated On: August 17th, 2024] [Originally Added On: April 18th, 2010]
- Longevity Meme Newsletter, April 19 2010 [Last Updated On: August 17th, 2024] [Originally Added On: April 19th, 2010]
- Let Them Eat Wheat [Last Updated On: August 17th, 2024] [Originally Added On: April 19th, 2010]
- An Appetite for Alzheimer’s Avoidance [Last Updated On: August 17th, 2024] [Originally Added On: April 19th, 2010]
- Steps Towards Controlling Regeneration [Last Updated On: August 17th, 2024] [Originally Added On: April 20th, 2010]
- Another View of What to Do About Aging [Last Updated On: August 17th, 2024] [Originally Added On: April 20th, 2010]
- Rare flowers and common herbal supplements get unmasked with plant DNA barcoding [Last Updated On: August 17th, 2024] [Originally Added On: April 21st, 2010]
- Steps Towards Controlling Regeneration [Last Updated On: August 17th, 2024] [Originally Added On: April 21st, 2010]
- Another View of What to Do About Aging [Last Updated On: August 17th, 2024] [Originally Added On: April 21st, 2010]
- Stopping Metastasis [Last Updated On: August 17th, 2024] [Originally Added On: April 21st, 2010]
- Humanity+ Summit at Harvard [Last Updated On: August 17th, 2024] [Originally Added On: April 21st, 2010]
- Stopping Metastasis [Last Updated On: August 17th, 2024] [Originally Added On: April 22nd, 2010]
- Humanity+ Summit at Harvard [Last Updated On: August 17th, 2024] [Originally Added On: April 22nd, 2010]
- An Update on Scent and Longevity [Last Updated On: August 17th, 2024] [Originally Added On: April 22nd, 2010]
- Tissue Engineered Skin Progresses [Last Updated On: August 17th, 2024] [Originally Added On: April 22nd, 2010]
- Because Someone Has to State the Obvious [Last Updated On: August 17th, 2024] [Originally Added On: April 23rd, 2010]
- Deciphering Regeneration [Last Updated On: August 17th, 2024] [Originally Added On: April 23rd, 2010]
- Politics and Historical Aspirations to Engineered Longevity [Last Updated On: August 17th, 2024] [Originally Added On: April 24th, 2010]
- Exercise and Alzheimer's Disease [Last Updated On: August 17th, 2024] [Originally Added On: April 24th, 2010]