Ash Mogg, 36, who has had IVF cancelled due to COVID-19, outside her home in Toronto on March 20, 2020.
Tijana Martin/The Globe and Mail
Ash Mogg and her partner waited nearly a year on a list for provincially funded IVF in Ontario. Ms. Mogg, who is 36 and has a low egg reserve, was finally about to start the process in two weeks, but on Wednesday a nurse phoned with heartbreaking news. With all the uncertainty around COVID-19, the Toronto hospital was cancelling infertility treatments indefinitely.
I cried for five hours," Ms. Mogg said. "This whole situation, with COVID, in some ways it has the same feeling as infertility. Everything is so uncertain theres nothing to hold onto.
In the past few days, fertility clinics across Canada have been informing patients that new treatment cycles are being put on hold. They made the move after the Canadian Fertility and Andrology Society, which is not a regulatory body but provides guidance to the industry, issued a recommendation on Wednesday to postpone new insemination, in vitro fertilization and frozen embryo transfers until further notice, citing concerns about health-care resources. (The only exception would be for urgent cases involving cancer patients.)
Story continues below advertisement
Read also: IVF was my last hope to have a baby. All Canadians deserve that hope, too
The American Society for Reproductive Medicine released a similar advisory. And in Europe, the European Society of Human Reproduction and Embryology has cautioned that all fertility patients considering or planning treatment should avoid becoming pregnant at this time, citing the lack of information around how the novel coronavirus that causes COVID-19 affects early pregnancy.
For all the jokes about a forthcoming COVID-19 baby boom as couples around the world isolate in their homes some health professionals are raising red flags about whether its wise to get pregnant amid the outbreak. This alarming warning is driven by concerns about the strain on an already stretched health-care system, a lack of data around how the virus affects the first and second trimesters, and unease about whether hospitals will have the capacity to provide proper care for pregnant women and newborns.
For people like Ms. Mogg, the idea of having to press pause on starting a family is yet another devastating layer to this crisis.
When everything started shutting down, I kind of suspected something like this was going to happen, but it was still a blow, she said. Timing is obviously critical for me.
Fiona Mattatall, a Calgary-based obstetrician and gynecologist, said given all of the uncertainty around COVID-19, she would suggest families consider delaying attempts at getting pregnant until more is known.
This is only a virus weve known about for months, not years, Dr. Mattatall said. When it comes to the first-trimester exposure, it is a giant question mark.
One good bit of news is that an analysis of amniotic fluid and cord blood from nine infected woman who delivered at Zhongnan Hospital of Wuhan University in China this year didnt detect the virus.
Story continues below advertisement
This is hopeful, early information that babies may be protected it the womb, Dr. Mattatall said, adding its still too early to say for certain. (Researchers also determined the virus was not present in breast milk.)
As for the risk to mothers, reports from China suggest that the majority of pregnant woman with confirmed cases suffered just mild to moderate symptoms, and babies born to infected mothers have also done well.
Vanessa Poliquin, co-chair of the infectious disease committee of the Society of Obstetricians and Gynaecologists of Canada, said the absence of information isnt necessarily a bad thing. The virus has been spreading around the world for months now. Its conceivable, said Dr. Poliquin, that women are being infected while pregnant in their first trimester.
And we havent heard of a spike in miscarriages and we havent heard of a spike in rates of abnormalities being seen on anatomy scans, she said. This was not the case with the Zika virus, she said, where health providers saw problems and sounded the alarm.
Story continues below advertisement
So far SOGC has not issued any warnings about delaying pregnancy, but the agencys chief executive officer, Jennifer Blake, said it may be worth considering.
The big unknown is how the pandemic will affect our health-care system and the ability to give routine pregnancy care. For example, will you be able to get an ultrasound when and where you might normally expect, she said. If its an option you may want to wait. If thats not an option, we will make sure you get the care you need.
Tom Hannam, founder of Hannam Fertility in Toronto, said part of the problem is no one knows how long the outbreak will last.
Were looking at something that could be three months or seven months or a year and a half. None of us knows, he said. Whats it going to be like going to a hospital nine months from now? Is it going to be a healthy and safe birth experience?
Some clues can be gleaned from other cities.
Edith Cheng, chief of maternal-fetal medicine at University of Washington hospital in Seattle, one of the early North American epicentres for the outbreak, said theyre currently trying to sort through complicated logistics.
Story continues below advertisement
At present, the hospitals policy is that patients who are positive for COVID-19 cannot have guests. So an infected woman in labour would need to be alone.
Just 12 hours ago [our] pediatric leaders said we are now going to have to recommend, for sure, that [positive] moms and babies are separated because of some limited and new data that reports that babies less than a year old are potentially at higher risk, Dr. Cheng said.
Mothers are able to refuse this recommendation, but what happens at that point is still under discussion.
The complications around infected mothers means it takes more staff resources to handle safely. A delivery earlier this week required 13 staffers.
London is another city thats experiencing a crush of new COVID-19 cases. Last week, we had no cases at my hospital, said Rosemary Townsend, who works at a hospital in the citys south end. This week we have over 30 confirmed.
Hours earlier, her unit delivered its first baby to a mother suspected of being COVID-19 positive. (The confirmation test is pending.)
Story continues below advertisement
In that case, the woman knew she was symptomatic and called in advance. An official met her and her partner in the parking lot and put masks on them. Usually women are moved to different parts of the maternity ward before and after delivery, but in this case the patient was in an isolated area.
Asked if she thinks families should postpone plans to try and get pregnant, Dr. Townsend said she just had this conversation with a friend who happens to work in health care.
Shes 38. She decided that she doesnt want to wait. The risk of waiting and delaying pregnancy is greater than the risk of getting pregnant in the middle of whats going on, Dr. Townsend said.
Sign up for the Coronavirus Update newsletter to read the days essential coronavirus news, features and explainers written by Globe reporters.
Read more here:
Coronavirus pandemic spurs halt to fertility treatments - The Globe and Mail
- World Health Organization reference values for human semen characteristics [Last Updated On: August 17th, 2024] [Originally Added On: April 6th, 2010]
- Economic consequences of overweight and obesity in infertility: a framework for evaluating the costs and outcomes of fertility care [Last Updated On: August 17th, 2024] [Originally Added On: April 6th, 2010]
- Maternal metabolism and obesity: modifiable determinants of pregnancy outcome [Last Updated On: August 17th, 2024] [Originally Added On: April 6th, 2010]
- Brain imaging studies of appetite in the context of obesity and the menstrual cycle [Last Updated On: August 17th, 2024] [Originally Added On: April 6th, 2010]
- The impact of body mass index on semen parameters and reproductive hormones in human males: a systematic review with meta-analysis [Last Updated On: August 17th, 2024] [Originally Added On: April 6th, 2010]
- Options for fertility preservation in prepubertal boys [Last Updated On: August 17th, 2024] [Originally Added On: April 6th, 2010]
- Xenografting of testicular tissue from an infant human donor results in accelerated testicular maturation [Last Updated On: August 17th, 2024] [Originally Added On: April 14th, 2010]
- Karyotype of miscarriages in relation to maternal weight [Last Updated On: August 17th, 2024] [Originally Added On: April 14th, 2010]
- Endoglandular trophoblast, an alternative route of trophoblast invasion? Analysis with novel confrontation co-culture models [Last Updated On: August 17th, 2024] [Originally Added On: April 14th, 2010]
- Regulation of extravillous trophoblast invasion by uterine natural killer cells is dependent on gestational age [Last Updated On: August 17th, 2024] [Originally Added On: April 14th, 2010]
- Functional regulation of thymic stromal lymphopoietin on proliferation and invasion of trophoblasts in human first-trimester pregnancy [Last Updated On: August 17th, 2024] [Originally Added On: April 14th, 2010]
- Home self-administration of vaginal misoprostol for medical abortion at 50-63 days compared with gestation of below 50 days [Last Updated On: August 17th, 2024] [Originally Added On: April 14th, 2010]
- Prospective study of the forearm bone mineral density of long-term users of the levonorgestrel-releasing intrauterine system [Last Updated On: August 17th, 2024] [Originally Added On: April 14th, 2010]
- Functional attenuation of human sperm by novel, non-surfactant spermicides: precise targeting of membrane physiology without affecting structure [Last Updated On: August 17th, 2024] [Originally Added On: April 14th, 2010]
- Characteristics indicating adenomyosis coexisting with leiomyomas: a case-control study [Last Updated On: August 17th, 2024] [Originally Added On: April 14th, 2010]
- The risk of post-molar gestational trophoblastic neoplasia is higher in heterozygous than in homozygous complete hydatidiform moles [Last Updated On: August 17th, 2024] [Originally Added On: April 14th, 2010]
- Cumulative ongoing pregnancy rate achieved with oocyte vitrification and cleavage stage transfer without embryo selection in a standard infertility program [Last Updated On: August 17th, 2024] [Originally Added On: April 14th, 2010]
- Pregnancy outcome in female childhood cancer survivors [Last Updated On: August 17th, 2024] [Originally Added On: April 14th, 2010]
- Offering excess oocyte aspiration and vitrification to patients undergoing stimulated artificial insemination cycles can reduce the multiple pregnancy risk and accumulate oocytes for later use [Last Updated On: August 17th, 2024] [Originally Added On: April 14th, 2010]
- Avoidance of weekend oocyte retrievals during GnRH antagonist treatment by simple advancement or delay of hCG administration does not adversely affect IVF live birth outcomes [Last Updated On: August 17th, 2024] [Originally Added On: April 14th, 2010]
- Who should pay for assisted reproductive techniques? Answers from patients, professionals and the general public in Germany [Last Updated On: August 17th, 2024] [Originally Added On: April 14th, 2010]
- Sperm donor limits that control for the 'relative' risk associated with the use of open-identity donors [Last Updated On: August 17th, 2024] [Originally Added On: April 14th, 2010]
- Long-term cryostorage of sperm in a human sperm bank does not damage progressive motility concentration [Last Updated On: August 17th, 2024] [Originally Added On: April 14th, 2010]
- Screening for biomarkers of spermatogonia within the human testis: a whole genome approach [Last Updated On: August 17th, 2024] [Originally Added On: April 14th, 2010]
- Avoiding transgenerational risks of mitochondrial DNA disorders: a morally acceptable reason for sex selection? [Last Updated On: August 17th, 2024] [Originally Added On: May 20th, 2010]
- Cross border reproductive care in six European countries [Last Updated On: August 17th, 2024] [Originally Added On: May 20th, 2010]
- Morphometric dimensions of the human sperm head depend on the staining method used [Last Updated On: August 17th, 2024] [Originally Added On: May 20th, 2010]
- ESX1 gene expression as a robust marker of residual spermatogenesis in azoospermic men [Last Updated On: August 17th, 2024] [Originally Added On: May 20th, 2010]
- Innovative virtual reality measurements for embryonic growth and development [Last Updated On: August 17th, 2024] [Originally Added On: May 20th, 2010]
- Consecutive or non-consecutive recurrent miscarriage: is there any difference in carrier status? [Last Updated On: August 17th, 2024] [Originally Added On: May 20th, 2010]
- A longitudinal study of contraception and pregnancies in the same women followed for a quarter of a century [Last Updated On: August 17th, 2024] [Originally Added On: May 20th, 2010]
- Predictors of bleeding and user satisfaction during consecutive use of the levonorgestrel-releasing intrauterine system [Last Updated On: August 17th, 2024] [Originally Added On: May 20th, 2010]
- Direct proportional relationship between endometrioma size and ovarian parenchyma inadvertently removed during cystectomy, and its implication on the management of enlarged endometriomas [Last Updated On: August 17th, 2024] [Originally Added On: May 20th, 2010]
- Large prospective, pregnancy and infant follow-up trial assures the health of 1000 fetuses conceived after treatment with the GnRH antagonist ganirelix during controlled ovarian stimulation [Last Updated On: August 17th, 2024] [Originally Added On: May 20th, 2010]
- Altered aquaporin expression in women with polycystic ovary syndrome: hyperandrogenism in follicular fluid inhibits aquaporin-9 in granulosa cells through the phosphatidylinositol 3-kinase pathway [Last Updated On: August 17th, 2024] [Originally Added On: May 20th, 2010]
- Fast-release orodispersible tramadol as analgesia in hysterosalpingography with a metal cannula or a balloon catheter [Last Updated On: August 17th, 2024] [Originally Added On: May 20th, 2010]
- Xenotransplantation of cryopreserved human ovarian tissue into murine back muscle [Last Updated On: August 17th, 2024] [Originally Added On: May 20th, 2010]
- Predictors of psychological distress in patients starting IVF treatment: infertility-specific versus general psychological characteristics [Last Updated On: August 17th, 2024] [Originally Added On: May 20th, 2010]
- Psychological adjustment, knowledge and unmet information needs in women undergoing PGD [Last Updated On: August 17th, 2024] [Originally Added On: May 20th, 2010]
- Mothers of IVF and spontaneously conceived twins: a comparison of prenatal maternal expectations, coping resources and maternal stress [Last Updated On: August 17th, 2024] [Originally Added On: May 20th, 2010]
- Psychological well-being and sexarche in women with polycystic ovary syndrome [Last Updated On: August 17th, 2024] [Originally Added On: May 20th, 2010]
- Is human fecundity declining in Western countries? [Last Updated On: August 17th, 2024] [Originally Added On: May 20th, 2010]
- Impaired glucose tolerance, type 2 diabetes and metabolic syndrome in polycystic ovary syndrome: a systematic review and meta-analysis [Last Updated On: August 17th, 2024] [Originally Added On: June 5th, 2010]
- Current achievements and future research directions in ovarian tissue culture, in vitro follicle development and transplantation: implications for fertility preservation [Last Updated On: August 17th, 2024] [Originally Added On: June 5th, 2010]
- Human studies on genetics of the age at natural menopause: a systematic review [Last Updated On: August 17th, 2024] [Originally Added On: June 5th, 2010]
- Beyond oxygen: complex regulation and activity of hypoxia inducible factors in pregnancy [Last Updated On: August 17th, 2024] [Originally Added On: June 5th, 2010]
- Current knowledge of the aetiology of human tubal ectopic pregnancy [Last Updated On: August 17th, 2024] [Originally Added On: June 5th, 2010]
- Economic contraction and birth outcomes: an integrative review [Last Updated On: August 17th, 2024] [Originally Added On: June 5th, 2010]
- Teratogenic mechanisms of medical drugs [Last Updated On: August 17th, 2024] [Originally Added On: June 5th, 2010]
- Levels of semenogelin in human spermatozoa decrease during capacitation: involvement of reactive oxygen species and zinc [Last Updated On: August 17th, 2024] [Originally Added On: June 17th, 2010]
- Apoptosis and meiotic segregation in ejaculated sperm from Robertsonian translocation carrier patients [Last Updated On: August 17th, 2024] [Originally Added On: June 17th, 2010]
- In humans, zona pellucida glycoprotein-1 binds to spermatozoa and induces acrosomal exocytosis [Last Updated On: August 17th, 2024] [Originally Added On: June 17th, 2010]
- Variants of the EPPIN gene affect the risk of idiopathic male infertility in the Han-Chinese population [Last Updated On: August 17th, 2024] [Originally Added On: June 17th, 2010]
- Epidermal clitoral inclusion cysts: not a rare complication of female genital mutilation [Last Updated On: August 17th, 2024] [Originally Added On: June 17th, 2010]
- PCOSMIC: a multi-centre randomized trial in women with PolyCystic Ovary Syndrome evaluating Metformin for Infertility with Clomiphene [Last Updated On: August 17th, 2024] [Originally Added On: June 17th, 2010]
- Single versus double intrauterine insemination in multi-follicular ovarian hyperstimulation cycles: a randomized trial [Last Updated On: August 17th, 2024] [Originally Added On: June 17th, 2010]
- Soluble HLA-G is an independent factor for the prediction of pregnancy outcome after ART: a German multi-centre study [Last Updated On: August 17th, 2024] [Originally Added On: June 17th, 2010]
- Obstetric outcomes after transfer of vitrified blastocysts [Last Updated On: August 17th, 2024] [Originally Added On: June 17th, 2010]
- Occasional involvement of the ovary in Ewing sarcoma [Last Updated On: August 17th, 2024] [Originally Added On: June 17th, 2010]
- Y chromosome microdeletions, sperm DNA fragmentation and sperm oxidative stress as causes of recurrent spontaneous abortion of unknown etiology [Last Updated On: August 17th, 2024] [Originally Added On: June 17th, 2010]
- Development and preliminary validation of the fertility status awareness tool: FertiSTAT [Last Updated On: August 17th, 2024] [Originally Added On: June 17th, 2010]
- Xenotransplantation of human ovarian tissue to nude mice: comparison between four grafting sites [Last Updated On: August 17th, 2024] [Originally Added On: June 17th, 2010]
- Involvement of CFTR in oviductal HCO3- secretion and its effect on soluble adenylate cyclase-dependent early embryo development [Last Updated On: August 17th, 2024] [Originally Added On: June 17th, 2010]
- Effect of endometriosis on the protein expression pattern of follicular fluid from patients submitted to controlled ovarian hyperstimulation for in vitro fertilization [Last Updated On: August 17th, 2024] [Originally Added On: June 17th, 2010]
- Activin A regulates trophoblast cell adhesive properties: implications for implantation failure in women with endometriosis-associated infertility [Last Updated On: August 17th, 2024] [Originally Added On: June 17th, 2010]
- Clinical significance of sperm DNA damage in assisted reproduction outcome [Last Updated On: August 17th, 2024] [Originally Added On: June 17th, 2010]
- Fall in implantation rates following ICSI with sperm with high DNA fragmentation [Last Updated On: August 17th, 2024] [Originally Added On: June 17th, 2010]
- Prevalence of unsuspected uterine cavity abnormalities diagnosed by office hysteroscopy prior to in vitro fertilization [Last Updated On: August 17th, 2024] [Originally Added On: July 21st, 2010]
- Ultra-conservative fertility-sparing strategy for bilateral borderline ovarian tumours: an 11-year follow-up [Last Updated On: August 17th, 2024] [Originally Added On: July 21st, 2010]
- Fertility after autologous ovine uterine-tubal-ovarian transplantation by vascular anastomosis to the external iliac vessels [Last Updated On: August 17th, 2024] [Originally Added On: July 21st, 2010]
- Uterus transplantation in the baboon: methodology and long-term function after auto-transplantation [Last Updated On: August 17th, 2024] [Originally Added On: July 21st, 2010]
- Prestimulation parameters predicting live birth in anovulatory WHO Group II patients undergoing ovulation induction with gonadotrophins [Last Updated On: August 17th, 2024] [Originally Added On: July 21st, 2010]
- Transfer of a selected single blastocyst optimizes the chance of a healthy term baby: a retrospective population based study in Australia 2004-2007 [Last Updated On: August 17th, 2024] [Originally Added On: July 21st, 2010]
- Disclosure patterns of mode of conception among mothers and fathers-5-year follow-up of the Copenhagen Multi-centre Psychosocial Infertility (COMPI) cohort [Last Updated On: August 17th, 2024] [Originally Added On: July 21st, 2010]
- Assisted reproductive technology in Europe, 2006: results generated from European registers by ESHRE [Last Updated On: August 17th, 2024] [Originally Added On: July 21st, 2010]
- A decade of sperm washing: clinical correlates of successful insemination outcome [Last Updated On: August 17th, 2024] [Originally Added On: July 21st, 2010]
- Sperm DNA integrity in cancer patients before and after cytotoxic treatment [Last Updated On: August 17th, 2024] [Originally Added On: July 21st, 2010]
- Speriolin is a novel human and mouse sperm centrosome protein [Last Updated On: August 17th, 2024] [Originally Added On: July 21st, 2010]
- No influence of body mass index on first trimester fetal growth [Last Updated On: August 17th, 2024] [Originally Added On: July 21st, 2010]
- HLA sharing among couples appears unrelated to idiopathic recurrent fetal loss in Saudi Arabia [Last Updated On: August 17th, 2024] [Originally Added On: July 21st, 2010]