Written by Dipanita Nath, Edited by Explained Desk | Pune | Updated: July 26, 2020 8:34:40 am Professor Sarah Gilbert, who is leading development of a coronavirus vaccine at Oxford University, in Oxford, April 24, 2020. (Mary Turner/The New York Times)
Earlier this week, there was positive news on the Oxford vaccine candidate, one of a clutch of frontrunner candidates to protect the world from the SARS-CoV-2 virus that had, until Friday (July 24) morning, infected nearly 15.5 million people and killed over 630,000 worldwide.
Leading its development is a British scientist who plays the oboe, cycles to work, and is the mother of triplets. Dr Sarah Gilbert was famous in the scientific community as a brilliant vaccinologist; with the success in early trials, she and ChAdOx1 nCoV-19, the vaccine candidate her team is working on has been spotlighted as never before.
Gilbert and co-authors published the results of the early trials in the medical journal, The Lancet, on July 20, titled Safety and immunogenicity of the ChAdOx1 nCoV-19 vaccine against SARS-CoV-2: a preliminary report of a phase 1/2, single-blind, randomised controlled trial. They wrote: ChAdOx1 nCoV-19 showed an acceptable safety profile, and homologous boosting increased antibody responses. Which means that the vaccine candidate had induced an immune response (which is what vaccines are supposed to do), and was safe for people.
Dont miss from Explained | How corona of the virus changes into a hairpin shape and why
What is Dr Gilberts work in the field of vaccine development?
Dr Gilbert is one of the leading vaccinologists in the world. She is professor of vaccinology at Oxford Universitys Jenner Institute, a prestigious vaccine research centre, and one of the two founders of its spin-out company, Vaccitech, which develops immunotherapy products to treat and prevent infectious disease and cancer.
For more than 15 years, Dr Gilbert has been making and testing vaccines that trigger T cells a type of white blood cells to respond to antigens from malaria, influenza, and tuberculosis, among others.
Her work also includes developing vaccines for influenza and emerging diseases such as Lassa, Nipah, CCHF, and Middle East Respiratory Syndrome (MERS). MERS, which appeared in 2014, too, is caused by a coronavirus. A vaccine against MERS has been tested in clinical trials in the UK, and is now in trials in Saudi Arabia, where the virus is endemic, says Gilberts page on the Jenner Institute website.
The vaccine for MERS involved using the adenovirus (which causes common colds) from a chimpanzee embedded with the genetic material of the MERS virus. For the Covid-19 vaccine, the Oxford scientists used the adenovirus of a chimpanzee embedded with the genetic material from the spike protein, which the coronavirus uses to pierce the cell. In tests till now, bodies of participants have responded as if they were infected with the coronavirus.
Express Explainedis now onTelegram. Clickhere to join our channel (@ieexplained)and stay updated with the latest
What is known about the acclaimed scientists life away from her work?
Dr Gilbert has not given many interviews since the publication of the results of the early phase trials. Earlier profiles of the scientist in the UK media have said that as a child in Northamptonshires Kettering High School for Girls, she was quiet, polite, and studious, getting a lot of As in studies.
Gilbert belongs to a family of musicians, and her mother, Hazel, was part of the towns operatic society. By the age of 17, however, Gilbert was sure that she wanted to be a medical researcher. After obtaining a degree in biology at the University of East Anglia and a PhD in biochemistry from the University of Hull, Dr Gilbert worked at a number of biotechnology companies, among them Delta, where she learnt about making medicines.
Profiles on Prof Gilbert have noted that she became a vaccine specialist rather by accident. In 1994, when she entered Oxford University to join Professor Adrian Hills lab in a senior postdoc position, it was to work on human genetics. That highlighted the role of a particular type of immune response in protection against malaria, and so the next thing to move on to was to make a vaccine that would work through that type of immune response and thats how I got into vaccines, she told UKs The Telegraph newspaper in an interview.
By 2007, Dr Gilbert, who had become a reader at Oxford University three years previously, had won a project grant from the Wellcome Trust, and had begun work on an influenza vaccine. She has developed two vaccines for the disease so far, and has said that her ultimate aim is to be able to develop her team of scientists to be the leaders in vaccine research in the world.
Many people are fascinated with Dr Gilberts success in balancing the extra demands that women with a career in science face.
According to UNESCO, women make up less than 30 per cent of the worlds researchers. In science, technology, engineering and mathematics, women also publish less, are paid less for their research and do not progress as far as men in their careers.
On the website of the Nuffeld Department of Medicine (of which Jenner Institute, where she works, is a part), Dr Gilbert has been quoted as saying: Work life balance is very difficult, and impossible to manage unless you have good support. Because I had triplets in 1998, nursery fees would have cost more than my entire income as a post-doctoral scientist, so my partner has had to sacrifice his own career in order to look after our children.
She described how 18 weeks of paid maternity leave with three premature babies to care for and work to be completed, was tough: If there is a three-year grant and a woman wants a year-long maternity leave, it can disrupt the progress of the project. The situation becomes worse if more than one person is away simultaneously.
Dr Gilberts advice to women: One of the good things about being a scientist is that the hours are not fixed, so there is a fair amount of flexibility for working mothers. Having said that, there are also times when things (such as overseas conferences and important meetings) are fixed and you have to make sacrifices. It is exceptionally hard work. Its important to plan ahead, and make sure you have people who are willing to cover for you at home while you work. That might be your partner or relatives, or you may be able to buy in help.
Her own children seem to have survived unscathed, but none of them wants to be scientists, she said.
Dr Gilbert is cautiously hopeful. In an interview to the BBC, she said, Nobody can be absolutely sure that it is possible. Thats why we have to do trials. I think the prospects are very good but it is not completely certain.
The Indian Express is now on Telegram. Click here to join our channel (@indianexpress) and stay updated with the latest headlines
For all the latest Explained News, download Indian Express App.
The Indian Express (P) Ltd
See the article here:
- June 11th At Westport, CT: Federal Red Flags, HIPAA Security Rules and Fraud Prevention [Last Updated On: November 7th, 2009] [Originally Added On: November 7th, 2009]
- Do not learn Dvorak! [Last Updated On: November 7th, 2009] [Originally Added On: November 7th, 2009]
- You Can’t Solve Problems By Making It Illegal To Have The Problem [Last Updated On: November 7th, 2009] [Originally Added On: November 7th, 2009]
- A Force Fix for Healthcare [Last Updated On: November 7th, 2009] [Originally Added On: November 7th, 2009]
- Yahble, HIT, Bubblecon, BIZDEV!, Solid State [Last Updated On: November 7th, 2009] [Originally Added On: November 7th, 2009]
- 15 things that suck about the Palm Pre [Last Updated On: November 7th, 2009] [Originally Added On: November 7th, 2009]
- What an Indie Genomics Lab Looks Like [Last Updated On: November 7th, 2009] [Originally Added On: November 7th, 2009]
- Practice Fusion: Class D Felony? [Last Updated On: February 26th, 2010] [Originally Added On: February 26th, 2010]
- Practice Fusion Responds [Last Updated On: March 7th, 2010] [Originally Added On: March 7th, 2010]
- Practice Fusion: Do the math: $44,000 is a LIE [Last Updated On: March 10th, 2010] [Originally Added On: March 10th, 2010]
- How Much Until Doctors Approve of 23andMe? [Last Updated On: March 10th, 2010] [Originally Added On: March 10th, 2010]
- Biochemicals as Media, Not Methods [Last Updated On: March 10th, 2010] [Originally Added On: March 10th, 2010]
- More Practice Fusion Reality Distortion [Last Updated On: March 10th, 2010] [Originally Added On: March 10th, 2010]
- Same Test Results: 23andMe is Myriad is BRCA is Medicine [Last Updated On: March 12th, 2010] [Originally Added On: March 12th, 2010]
- BRCA is 23andMe is Myriad is Medicine [Last Updated On: March 13th, 2010] [Originally Added On: March 13th, 2010]
- Getting Serious About Genomics as Common Medical Practice [Last Updated On: March 15th, 2010] [Originally Added On: March 15th, 2010]
- The New John Mackey of Genetics: Linda Avey? [Last Updated On: March 15th, 2010] [Originally Added On: March 15th, 2010]
- Keep the Medical, Well, Medical [Last Updated On: March 16th, 2010] [Originally Added On: March 16th, 2010]
- If 23andMe shuts down, it won’t be for some mundane reason like the bills weren’t paid [Last Updated On: March 16th, 2010] [Originally Added On: March 16th, 2010]
- If I Run A Medical Practice, How Do I Use A 23andMe? [Last Updated On: March 17th, 2010] [Originally Added On: March 17th, 2010]
- 23andMe Contract in Bad Faith [Last Updated On: March 19th, 2010] [Originally Added On: March 19th, 2010]
- Doctors CANNOT Use 23andMe Due To 23andMe’s Bad Faith Contract [Last Updated On: March 20th, 2010] [Originally Added On: March 20th, 2010]
- Pathway Compared to 23andMe and Navigenics [Last Updated On: March 22nd, 2010] [Originally Added On: March 22nd, 2010]
- There’s a Word for “Views Differ” When One View Is The State [Last Updated On: March 24th, 2010] [Originally Added On: March 24th, 2010]
- Association for Molecular Pathology, et al. v. USPTO, et al. – Opinion [Last Updated On: March 29th, 2010] [Originally Added On: March 29th, 2010]
- Birth of a Super Villain [Last Updated On: April 3rd, 2010] [Originally Added On: April 3rd, 2010]
- “Medical Products” like 23andMe must not become the new “Financial Products” [Last Updated On: April 4th, 2010] [Originally Added On: April 4th, 2010]
- How I Would Apply Genomic Technology In Clinical Use Today [Last Updated On: April 5th, 2010] [Originally Added On: April 5th, 2010]
- Gmail Enterprise: World’s Best EMR [Last Updated On: April 6th, 2010] [Originally Added On: April 6th, 2010]
- Brief Primer on Health Law Compliance [Last Updated On: April 9th, 2010] [Originally Added On: April 9th, 2010]
- Spoiler: You ARE the “Valids” [Last Updated On: April 9th, 2010] [Originally Added On: April 9th, 2010]
- Rachel Lehmann-Haupt Line by Line Take Down [Last Updated On: April 9th, 2010] [Originally Added On: April 9th, 2010]
- Is Medicare Bankrupt? What the Hell Is Going On? [Last Updated On: April 17th, 2010] [Originally Added On: April 17th, 2010]
- The Big Shuffle: Medicare Cuts Rates by 21.3% (but not “technically”) [Last Updated On: April 17th, 2010] [Originally Added On: April 17th, 2010]
- “Tech Hiring Binge” == “Fear for Your Job, Nerds” [Last Updated On: April 18th, 2010] [Originally Added On: April 18th, 2010]
- How Bad is Bad? $.20 on the Private Medical Insurance Dollar [Last Updated On: April 20th, 2010] [Originally Added On: April 20th, 2010]
- Update: How Bad is Bad? It Used to Be $.45 on the Medical Insurance Dollar [Last Updated On: April 20th, 2010] [Originally Added On: April 20th, 2010]
- World’s Best “EMR” for $1000: Google Spreadsheets + iPad [Last Updated On: April 21st, 2010] [Originally Added On: April 21st, 2010]
- Don’t Insult Me with your “AOL Keyword” Strategy, Google Health [Last Updated On: April 21st, 2010] [Originally Added On: April 21st, 2010]
- How to Play LAWGAMES [Last Updated On: April 23rd, 2010] [Originally Added On: April 23rd, 2010]
- Top 4 Predatory Schemes Encroaching on American Medicine: Part 1 [Last Updated On: April 25th, 2010] [Originally Added On: April 25th, 2010]
- What’s the Big Deal About iPads? [Last Updated On: April 27th, 2010] [Originally Added On: April 27th, 2010]
- Got Google Android for Google I/O [Last Updated On: April 27th, 2010] [Originally Added On: April 27th, 2010]
- Google Enterprise meets HIPAA and HITECH Compliant Laws [Last Updated On: April 29th, 2010] [Originally Added On: April 29th, 2010]
- Pixels of Accuracy CHALENGE: Diagnostic Medical Imaging [Last Updated On: April 29th, 2010] [Originally Added On: April 29th, 2010]
- 23andMe Launder AlioGenetics Doesn’t Even Bother to Remove 23andMe Logo [Last Updated On: April 30th, 2010] [Originally Added On: April 30th, 2010]
- Anthem of CT Denies $600 Until “Subscriber Responds to our Coordination of Benefits Questionnaire” [Last Updated On: May 1st, 2010] [Originally Added On: May 1st, 2010]
- Apple And Google Team Up To Launch Revolutionary Mobile Health System [Last Updated On: May 1st, 2010] [Originally Added On: May 1st, 2010]
- Funny Pictures from This Year Building the Medical Practice [Last Updated On: May 6th, 2010] [Originally Added On: May 6th, 2010]
- Remote Medical Video Monitoring on iPad and iPhone [Last Updated On: May 7th, 2010] [Originally Added On: May 7th, 2010]
- Google Calendar Overhead Waiting Room Display [Last Updated On: May 7th, 2010] [Originally Added On: May 7th, 2010]
- Various Whiteboards on Solid State Medical Operations [Last Updated On: May 7th, 2010] [Originally Added On: May 7th, 2010]
- The Raw Facts about Counsyl [Last Updated On: May 7th, 2010] [Originally Added On: May 7th, 2010]
- Brawndo: Still Mutilating Thirst, Still Not Yet Sold at the Stop-n-Shop Pharmacy [Last Updated On: May 9th, 2010] [Originally Added On: May 9th, 2010]
- Video: Google Enterprise to Outsource Medical Administration [Last Updated On: May 9th, 2010] [Originally Added On: May 9th, 2010]
- Gattaca: “The Matrix” of Genomics [Last Updated On: May 11th, 2010] [Originally Added On: May 11th, 2010]
- 23andMe Now Diagnoses Fatal Tay-Sachs Disease [Last Updated On: May 12th, 2010] [Originally Added On: May 12th, 2010]
- Why Was Pathway Targeted for FDA Enforcement and Not 23andMe? [Last Updated On: May 15th, 2010] [Originally Added On: May 15th, 2010]
- John Dolan on Aging and the Horrifying Conclusion of GWAS [Last Updated On: May 16th, 2010] [Originally Added On: May 16th, 2010]
- Sam R. Riley Wants To Tell You About Practice Fusion [Last Updated On: May 17th, 2010] [Originally Added On: May 17th, 2010]
- Response to “Genomic Medicine: Lost” [Last Updated On: May 19th, 2010] [Originally Added On: May 19th, 2010]
- Death And Taxes: CMS to IRS [Last Updated On: May 19th, 2010] [Originally Added On: May 19th, 2010]
- Please Stop Antagonizing the AMA [Last Updated On: May 26th, 2010] [Originally Added On: May 26th, 2010]
- Dan Vorhaus, Attorney At Law, Legally Advises Medical Doctors Can Use 23andMe To Provide Medical Advice [Last Updated On: May 28th, 2010] [Originally Added On: May 28th, 2010]
- Singularity Summit 2010 in San Francisco to Explore Intelligence Augmentation [Last Updated On: June 7th, 2010] [Originally Added On: June 7th, 2010]
- OpenPCR: DNA amplification for anyone [Last Updated On: June 10th, 2010] [Originally Added On: June 10th, 2010]
- FDA sends letters to 5 genetic testing companies [Last Updated On: June 11th, 2010] [Originally Added On: June 11th, 2010]
- Amazon And The NIH Team Up To Put Human Genome In The Cloud [Last Updated On: March 31st, 2012] [Originally Added On: March 31st, 2012]
- ReproSource Comments on New Study Linking Infertility to Genetics [Last Updated On: April 25th, 2012] [Originally Added On: April 25th, 2012]
- Genetics 101 Part 1: What are genes? - Video [Last Updated On: April 30th, 2012] [Originally Added On: April 30th, 2012]
- Red Ice Radio - David Icke - Hour 1 - The Manipulation of Humanity - Video [Last Updated On: April 30th, 2012] [Originally Added On: April 30th, 2012]
- Genetics Part 5: Human Genetic Disorders - Video [Last Updated On: April 30th, 2012] [Originally Added On: April 30th, 2012]
- C2CAM - The Nephilim, Genetic Manipulation [Last Updated On: April 30th, 2012] [Originally Added On: April 30th, 2012]
- Human Nature talk with Robert Sapolsky, Gabor Mate, James Gilligan, Richard Wilkinson - Video [Last Updated On: April 30th, 2012] [Originally Added On: April 30th, 2012]
- Human Genetic Diseases - Video [Last Updated On: April 30th, 2012] [Originally Added On: April 30th, 2012]
- Alien Scientist on Genetics, Implants [Last Updated On: April 30th, 2012] [Originally Added On: April 30th, 2012]
- Research and Markets: Genetics, 6th Edition International Student Version Continues To Educate Today's Students for ... [Last Updated On: May 4th, 2012] [Originally Added On: May 4th, 2012]
- Myriad Genetics to Present at the Bank of America Merrill Lynch 2012 Health Care Conference [Last Updated On: May 4th, 2012] [Originally Added On: May 4th, 2012]
- Genetics may explain some people's dislike of meat [Last Updated On: May 4th, 2012] [Originally Added On: May 4th, 2012]
- 'Blond Genes' May Vary Around the World [Last Updated On: May 4th, 2012] [Originally Added On: May 4th, 2012]