Click on any icon to hear that co-authors perspective on what the proposed guidelines mean for the region in which they work. Map compiled by Stephanie Dutchen

HMNews: What is the main goal of having a set of international guidelines?

Kendra Sirak: While some countries have developed rigorous standards that guide the scientific analysis of human remains, many others have few or no guidelines that ensure that this work is carried out responsibly and is both scientifically robust and sensitive to community perspectives. Everyone wants practical guidance that will be positive about the research enterprise while embracing high ethical standards.

Its our hope that these guidelines will raise the integrity of ancient DNA research around the world by minimizing damage to collections of human remains; ensuring sensitivity to the perspectives of stakeholder groups, especially when these groups are marginalized; and reducing opportunities for the misuse of results. We expect these guidelines will undergo further development as the field continues to evolve.

HMNews: Why now?

Jakob Sedig: Ancient DNA as a field has been growing rapidly, evolving from a promising technology to a mature field. The discussion about how to handle human remains and how to meaningfully involve diverse stakeholders has not yet caught up. More and more people are calling for clear, strong guidance that all researchers engaged in ancient DNA work can embrace.

Ancient DNA analysis has contributed vital new insights about the human past and has helped us understand the genetic roots of human diversity. It has disrupted nationalist and xenophobic narratives. It has challenged what many of us thought we knew about who we are and where we came from. But like any field that matters, its complex.

Because of the number of ancient individuals being analyzed, the socialand political nature of the work, and the challenges that ancient DNA findings have raised about theories proposed before we had such data, people are paying attention to ancient DNA. That makes it even more vital to articulate and adopt strong guidelines that work well everywhere.

HMNews: How did the team come up with these five guidelines?

Sedig: We took cues from archaeology and modern human genetics, which have established protocols for carrying out analyses on human remains and establishing stakeholder consent. We built on aspects of existing guidelines, such as those crafted by a group of North American scholars, including Indigenous scholars, published last year in the American Journal of Human Genetics.

Our diverse co-author groupparticularly those in Central and South America, Africa, Europe, South Asia, the Pacific, and East Asiafelt that these and other suggestions, while valuable, were not applicable in all world regions. Our virtual workshop led to monthslong discussions that took many different value systems and histories into account and sought balance between local contexts and general principles. We then wrote the manuscript.

Given that there was near-unanimous support and excitement about the final document among the workshop participants, we hope the broader community will embrace and build on these proposals. It would be wonderful if the proposals form a basis for official guidelines in the future.

HMNews: Why not just follow national or local government regulations wherever a project is being conducted?

Sirak: There are some places where laws are robust enough for that to be appropriate, but in other locales, we feel that researchers need to hold themselves to a higher standard than required by the laws currently in place.

HMNews: What are some of the needs and unique circumstances in different regions that shaped the guidelines?

Sirak: We have found that guidelines that work well for one region can come across as condescending or even colonialist in another. Many co-authors on this manuscript raised the point that indigeneity has different meanings in different places and is even used in some regions as a framework for oppression and discrimination against minority groups argued to be non-Indigenous. Thus, basing research ethics on a single definition can inadvertently reinforce rather than mitigate power imbalances in conducting and interpreting genetic analyses.

The videos our co-authors have shared speak to the many nuances of ethical ancient DNA research in the places where they live and work.

HMNews: Some critics say that ancient DNA research, which to a large extent has focused on and been conducted by white people from wealthy nations, has been a colonialist endeavor that siphons agency from marginalized groups. How do the proposed guidelines address these discussions about power and ownership?

Sedig: These are important conversations. We cant reiterate enough that our goal is to learn about the past in a sensitive, thoughtful, and ethical way. We do not want to contribute to exploitation; we want to do the opposite. We need to listen to and respect the people who are stakeholders in ancient DNA studiesincluding groups from the place of origin of the human remains being studiedand make sure their perspectives are represented in discussions about study design, research questions, and whether a project should proceed at all. Theres been a huge amount of progress in recent years in seeking local perspectives from the start to the conclusion of a study and incorporating that feedback into the project and publication. We have increasingly diverse groups of people who conduct the research as well.

We want to minimize harm and reduce inequity, and I believe the ancient DNA community has an extraordinary track record of providing arguments that do so. We know that in regions with histories of settler colonialism, we have to center Indigenous perspectives. We have to confront the colonial legacies of human remains collected in unethical ways and often sent abroad, and we should seek ways to mend the harms done, such as by considering how our research findings or the methods we are using might be helpful tools for facilitating repatriation of remains. We must ensure that local scientists and communities are as engaged as can be in ancient DNA research, particularly in places with histories of scientists conducting exploitative research. Researchers working in countries outside their own must prioritize establishing equitable collaborations that benefit local scholars and avoid carrying out parachute research at all costs.

When possible, those of us in positions of privilege should contribute to reducing structural inequities. Some ideas we propose in the guidelines are to help educate and train local community members and other stakeholders, assist with raising the curatorial standards of collections or developing museum exhibits, provide funds for training or attending professional meetings, and advocate for funding agencies to build more capacity for equitable ancient DNA research. We also need to ensure that we communicate results in ways that are accessible to nonscientists and the broader scholarly community. Lastly, we have to oppose those who use genetic data to support narratives of group superiority or to justify exclusionary policies.

At the same time, as scientists we need to make sure we can proceed in a way consistent with the scientific method. We cant ethically conduct a study without the guarantee that we can follow the data where they lead. This means that once stakeholder communities agree that publishing results would not cause them harm, the relevant portion of a manuscript wont be restricted. It also means the data must be made accessible at least so others can replicate or reevaluate results.

We have a loyalty to the facts we uncover as we learn about our shared humanity. In cases where the data we generate dont align with other forms of knowledge, such as traditional expertise or cultural beliefs, it is not our job to discredit or diminish that knowledge. Rather, those discrepancies highlight how comple
x an undertaking it is to understand the past and should be flagged in papers that result from the work.

Regarding ownership, we believe that whenever researchers are granted permission to study the remains of ancient individuals, they become stewards of that material with a responsibility to care for and respect it. They do not assume ownership of the remainsor of the data that arise from sequencing it.

HMNews: Some groups assert that stakeholder communities should decide whether and how certain kinds of ancient DNA data can be used in future analyses. How does this fit with the teams push for open data?

Sirak: We advocate for stakeholders having input into how data should be distributed and we advocate for open data. We believe that both goals can coexist.

Many of our co-authors felt strongly that ancient DNA data should always be made fully and publicly available. Other co-authors argued that when it comes to data from remains that might be meaningfully connected to present-day Indigenous communities, it could be appropriate to have usage restrictions. This was one of many debates we had, and in listening to one another, some of us changed our positions.

We all agreed that open data for ancient DNA is something to strive for. The data must be made available after publicationeither through full open access, which is ideal, or distributed by a professional organization without a stake in the research resultsso scholars can reproduce or challenge analyses. This also lowers the chances study results will be misused. We are proud that the raw data for nearly all ancient genomes published so far was made publicly available at or before the time of publication.

Finally, we agreed that Indigenous-led data repositories such as those now being developed could help mediate permissions when scholars wish to use data for purposes beyond those articulated in an original study plan.

HMNews: Given that equity is a priority, how accessible will this paper be to those who, for example, dont have paid access to the journal in which its being published or who arent fluent in English?

Sirak: Weve made our paper open access and applied the most flexible Creative Commons license to it, known as CC BY 4.0. That means its available for free to anyone in the public to read, distribute, adapt, and build upon. Our team members also have translated the text into more than 20 languages that they speak.

HMNews: Do you expect pushback from scientists who feel that the guidelines are too onerous and will make it harder to carry out research?

Sedig: We did receive feedback during the review process that the guidelines were too strongthat they would create a heavy burden for researchers from smaller labs or who are in the early stages of their careers. We respect this perspective and understand that were requesting a lot in terms of engaging with stakeholders and what could be called overhead beyond the research itself. However, we firmly believe that all ancient DNA studies, from an early-career stage onwards, should meet these ethical standards.

In a way, the proposals are merely concretizing the standards that are already emerging in the field. We believe that authors and journal editors feel their way toward this ethical framework during the review process. We believe that the proposals are practical and that early-career researchersincluding many who co-authored our articlewill benefit from having the principles clearly articulated and the guesswork reduced as they aim to carry out their research in an ethically principled way.

HMNews: What enforcement would there be if someone involved in ancient DNA research didnt follow these guidelines?

Sirak: Our co-authors do not represent any official organization, so we cannot make or enforce rules for anyone except ourselves. What our paper does represent is a grassroots, community-led pledge from representatives of a nontrivial faction of worldwide researchers engaged in this type of work. We have committed to adhering to a set of strong principles, and we invite others to hold us accountable to them.

It would be a great outcome if scientific journals, professional societies, or granting agencies found these proposals useful enough to turn into official guidelines, which would mean there could be professional repercussions for not adhering to them. The fact that scholars from such a diverse array of nations and disciplines have signed on to the guidelines at this stage makes us optimistic that they will be embraced in practice by laboratories and research groups as well as other groups engaged in ancient DNA research all over the world. But either way, its important to continue the global conversation.

This work was supported by the Australian Research Council Discovery Project (DP160100811), National Research Foundation South Africa, Brazilian National Council for Scientific and Technological Development (302163/2017-4), So Paulo Research Foundation/FAPESP (2018/23282-5), Francis Crick Institute (FC001595), Cancer Research UK, UK Medical Research Council, Wellcome Trust, Dutch Research Council (VI.C.191.070), Hungarian Academy of Sciences, Science and Engineering Research Board of India, Council of Scientific and Industrial Research in India (Ministry of Science and Technology, Government of India), European Research Council (ERC-2017-StG 804844-DAIRYCULTURES), Werner Siemens-Stiftung, John Templeton Foundation (6122), Howard Hughes Medical Institute, Max Planck Society, and the Max Planck Harvard Research Center for the Archaeoscience of the Ancient Mediterranean, and the National Geographic Society.

Interviews were edited for length and clarity.

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