How will Cell and Gene Therapy Usher in a New Industrial Revolution?
Cell and gene therapy companies are on the verge of transforming how we treat unmet medical needs such as cancer, rare diseases, genetic disorders and diabetes, to name only a few. By using a patients own cells and genes to fight disease, cell and gene therapy treatments deliver highly-targeted therapies and cures for unserved and underserved patients in need of solutions to a wide variety of intractable diseases.
What was once relegated to science fictionlike the miniaturized heroes sent into a human body in the Fantastic Voyage sci-fi movie of 1966has, to a large degree, become reality with modified cells being put into patients to act as virtual bots capable of clearing diseaseseven cancersfrom the body. New technologies are empowering science to do what would never have been thought possible years ago.
Understanding the complexities of how these novel personalized medicines actually work can be daunting and confusing for many people, especially for the patients who are in need of these new medicines and those who are non-scientific minded.
Jeff Galvin, CEO of American Gene Technologies (AGT), has helped a wide variety of audiences understand this new technology by explaining the similarities between the human cell and an organic computer. He explains that DNA is the operating system of the human cell. It contains commands for the cellular machinery called genes, which are coded in four symbols: A, G, T, and C (for the nucleotides adenine, guanine, thymine, and cytosine). The order of these nucleotides determines the instruction that a gene provides to the machine just like the order of 1s and 0s in your personal computer or cell phone determine the commands to be executed by the device. Galvin coined this human computer analogy to describe the work that his company is doing and what is actually taking place with cell and gene therapies to make new solutions for formerly unaddressable human diseases.
Galvin describes gene and cell therapy as the software revolution for the next 100 years: reprogramming DNA in cells to improve health. Scientists have long understood that viruses infect cells and hijack them with new instructions (viral DNA) to cause disease. Over the last few decades, methods have been developed to crack open viruses, scoop out their bad instructions that make cells sick, and replace them with new good instructions that improve the operation of the cell. In a way, the gene and cell therapy industry is hijacking the hijacker, says Galvin. We are taking viruses and converting them to updates to fix bugs or improve the operating system (DNA) of human cells. Just like viruses and updates on your computer work. The possibilities are endless. We can use these updates to repair a broken gene that is the root cause of a disease, insert new instructions into cells to improve their operation allowing them to do their jobs better, clear or protect the body from disease, or even change the operation of cells to make them little bots that can carry out functions that they would not normally do in your body, like clearing cancer. All of these things are within the scope of reprogramming the human computer.
American Gene Technologies (AGT), a biotech company located in Rockville, Maryland, is a company where Silicon Valley tech innovation and the human computer mindset is converging to rethink the approach to developing medicine.
AGTs CEO Jeff Galvin has shared that he and other cell and gene therapy leaders are on a mission to reprogram the human computer to save lives and improve outcomes for patients fighting infectious diseases, monogenic disorders, cancer and other devastating illnesses.
A serial tech innovator, Galvin made his mark as a Silicon Valley entrepreneur. He retired in his early 40s in 2002. His retirement was short-lived. When Galvin discovered the groundbreaking viral vector work of the National Institute of Healths (NIH) Dr. Roscoe Brady, he exited retirement to do what he always does: Vigorously pursue what he loves.
Galvin leapt out of retirementin 2007 to start AGT, and to continue developing Bradys technology.
I was very lucky to meet Roscoe Brady. When he showed me viral vectors and I realized we now had the ability to modify DNA with viruses, I immediately felt that this is the future of pharmaceuticals, stated Galvin. I could see the inherent power in this approach and how viral vectors could bring opportunities to new biotech companies to cure diseases that were formerly untreatable or incurable.
Bradys commitment to solving diseases and improving lives was also infectious. Dr. Brady was retiring, and it looked like this brilliant work was going to be shelved. explains Galvin. I saw it as too valuable and potentially world-changing to ignore. Dr. Brady agreed to stay on as a scientific advisor and I founded AGT with the mission to find the most efficient, effective, and fastest ways to bring this cutting edge technology to patients in need.
A lot of what I imagined as a computer programmer and software/IT specialist coming from the West Coast is actually coming true for this technology. This vision has fortunately attracted a lot of great scientists to our company and they are doing all of the rocket science. The concept is correct: We can use viral vectors to hijack the viruses that have been hijacking our cells for 1.5 billion years, using the inherent ability of viruses to infect cells and carry malevolent genetic code to deliver benevolent code instead,. Galvin stated.
What I am witnessing in our part of this industry is that high tech has come to drug development. The capabilities of everything we are doing is doubling every yearits like the computer revolution; every year youre getting more power while the price of the technology is going down, so youre getting exponential growth in power and value, Galvin commented.
Our approach is a major shift from old-style drug development, which relies on the random generation of thousands or tens of thousands of molecules. And then you try to screen them down via a cell model that gives you the effect youre looking for. And generally after two years and $10 million of investment, you have a few (drug programs) you can test in a mouse, and then one in 19 get into the clinic, stated Galvin.
What were doing at AGT and in the cell and gene therapy field is just different. Gene and cell therapy is about directed development. You can create highly targeted drugs that hit a specific cellular pathway and you can even narrow that down using specific promoters or chimeric envelopes so you can direct that drug to a certain cell type or even to a certain disease indicator, stated Galvin. By narrowing the drug to the particular tissue or particular disease indicator you are sparing all the healthy tissue, which is the main reason drugs drop out of clinical development, the side effects. Gene and cell therapy largely avoids this issue.
We can test some of these in cell models at the bench, then in animal models and be able to get to a go-no-go decision after $100K in investment. We might be able to characterize it so well at the bench that the clinical development becomes highly predictable. This turned out to be true with our HIV therapy, stated Galvin.
Galvin believes that AGTs cell and gene therapy platform will help contributeas part of a wider cell and gene therapy revolutionto the eradication of the $2 to $4 trillion in palliative care treatment costs replaced with one-and-done cures. Viral-vector based drug development platforms like the one AGT deploys will help find new gene and cell therapy treatments and cures for the approximately 7,000 rare diseases that impact approximately one in ten people across the globe.
The future of drug development, in my mind, is that the toolset will keep evolving like computers and software. Software developers used creativity to leverage a limited toolset to create value in the market. At AGT, were thinking about correcting DNA to improve human health and mitigate disease. Everything about technology is playing in our favor. If you were in computers a while ago and you saw mainframes turn into mini-computers and then micro computers you would have said, Eventually we will have these things in our pocket and you would have been right. The same is now true about drug development, stated Galvin, Nearly anything will be possible in the future as this technology continues to exponentially improve. In this high-tech revolution of gene and cell therapy, if you can dream it, you will eventually be able to do it!
AGT is part of an evolving, growing and groundbreaking cell and gene therapy cluster thriving in the BioHealth Capital Region.
Maryland is at the epicenter of the gene and cell therapy technological explosion Its all about the resources. They are starting to hit a critical mass here, added Galvin.
Steve has over 20 years experience in copywriting, developing brand messaging and creating marketing strategies across a wide range of industries, including the biopharmaceutical, senior living, commercial real estate, IT and renewable energy sectors, among others. He is currently the Principal/Owner of StoryCore, a Frederick, Maryland-based content creation and execution consultancy focused on telling the unique stories of Maryland organizations.
View post:
Reprogramming the Human Computer: Silicon Valley Meets Cell and Gene Therapy - BioBuzz
- About the Gene Therapy Review [Last Updated On: November 8th, 2009] [Originally Added On: November 8th, 2009]
- Contribute an Article [Last Updated On: November 8th, 2009] [Originally Added On: November 8th, 2009]
- EBSCO Publishing Deal [Last Updated On: November 8th, 2009] [Originally Added On: November 8th, 2009]
- Advertising Opportunities [Last Updated On: November 8th, 2009] [Originally Added On: November 8th, 2009]
- Instructions for Authors [Last Updated On: November 8th, 2009] [Originally Added On: November 8th, 2009]
- Isis Collaboration With Ortho-McNeil Inc for Metabolic Diseases [Last Updated On: November 8th, 2009] [Originally Added On: November 8th, 2009]
- Dystrophin Gene Transfer safe in Duchenne muscular dystrophy [Last Updated On: November 8th, 2009] [Originally Added On: November 8th, 2009]
- Researchers Identify Gene for Rare Form of Spinal Muscular Atrophy [Last Updated On: November 8th, 2009] [Originally Added On: November 8th, 2009]
- Fatal brain cancer tamed by New gene therapy [Last Updated On: November 8th, 2009] [Originally Added On: November 8th, 2009]
- Gene therapy effective in fighting obesity in mice [Last Updated On: November 8th, 2009] [Originally Added On: November 8th, 2009]
- Genzyme gene therapy for people with peripheral artery disease failed in a clinical trial to help them regain some mobility [Last Updated On: November 8th, 2009] [Originally Added On: November 8th, 2009]
- Gene Therapy May Stall Inherited Emphysema [Last Updated On: December 31st, 2009] [Originally Added On: December 31st, 2009]
- Gene Therapy and Stem Cells Save Limb [Last Updated On: December 31st, 2009] [Originally Added On: December 31st, 2009]
- Faulty Circuits (preview) [Last Updated On: August 17th, 2024] [Originally Added On: April 7th, 2010]
- Rare flowers and common herbal supplements get unmasked with plant DNA barcoding [Last Updated On: August 17th, 2024] [Originally Added On: April 20th, 2010]
- Biomarker Studies Could Realize Goal of More Effective and Personalized Cancer Medicine [Last Updated On: August 17th, 2024] [Originally Added On: April 27th, 2010]
- Schizophrenia shares genetic links with autism, genome study shows [Last Updated On: August 17th, 2024] [Originally Added On: May 12th, 2010]
- Alzheimer's: Forestalling the Darkness with New Approaches (preview) [Last Updated On: August 17th, 2024] [Originally Added On: May 28th, 2010]
- Alzheimer's: Forestalling the Darkness with New Approaches (preview) [Last Updated On: August 17th, 2024] [Originally Added On: May 28th, 2010]
- Large-Scale Autism Study Reveals Disorder's Genetic Complexity [Last Updated On: August 17th, 2024] [Originally Added On: June 12th, 2010]
- Large-Scale Autism Study Reveals Disorder's Genetic Complexity [Last Updated On: August 17th, 2024] [Originally Added On: June 12th, 2010]
- Cancer Therapy Goes Viral: Progress Is Made Tackling Tumors with Viruses [Last Updated On: August 17th, 2024] [Originally Added On: June 24th, 2010]
- Vaccines Derived from Patients' Tumor Cells Are Individualizing Cancer Treatment [Last Updated On: August 17th, 2024] [Originally Added On: June 26th, 2010]
- Vaccines Derived from Patients' Tumor Cells Are Individualizing Cancer Treatment [Last Updated On: August 17th, 2024] [Originally Added On: June 26th, 2010]
- A genome story: 10th anniversary commentary by Francis Collins [Last Updated On: August 17th, 2024] [Originally Added On: June 29th, 2010]
- Hair Trigger: How a Cell's Primary Cilium Functions as a Molecular Antenna [Last Updated On: August 17th, 2024] [Originally Added On: June 30th, 2010]
- Hair Trigger: How a Cell's Primary Cilium Functions as a Molecular Antenna [Last Updated On: August 17th, 2024] [Originally Added On: June 30th, 2010]
- DNA Drugs Come of Age (preview) [Last Updated On: August 17th, 2024] [Originally Added On: July 16th, 2010]
- 2 Genes Linked to Embryonic Brain Impairment in Down's Syndrome [Last Updated On: August 17th, 2024] [Originally Added On: July 22nd, 2010]
- 2 Genes Linked to Embryonic Brain Impairment in Down's Syndrome [Last Updated On: August 17th, 2024] [Originally Added On: July 22nd, 2010]
- Stem Cells from Reprogrammed Adult Cells Found to Bring Along Genetic Defects of Their Donors [Last Updated On: August 17th, 2024] [Originally Added On: October 11th, 2010]
- Was Darwin a Punk? A Q&A with Punker-Paleontologist Greg Graffin [Last Updated On: August 17th, 2024] [Originally Added On: October 11th, 2010]
- Was Darwin a Punk? A Q&A with Punker-Paleontologist Greg Graffin [Last Updated On: August 17th, 2024] [Originally Added On: October 11th, 2010]
- Parkinsonian Power Failure: Neuron Degeneration May Be Caused by a Cellular Energy System Breakdown [Last Updated On: August 17th, 2024] [Originally Added On: October 11th, 2010]
- Desperation Drives Parents to Dubious Autism Treatments (preview) [Last Updated On: August 17th, 2024] [Originally Added On: October 17th, 2010]
- Revolution Postponed: Why the Human Genome Project Has Been Disappointing (preview) [Last Updated On: August 17th, 2024] [Originally Added On: November 7th, 2010]
- Controlling the Brain with Light (preview) [Last Updated On: August 17th, 2024] [Originally Added On: November 7th, 2010]
- Optogenetics: Controlling the Brain with Light [Extended Version] [Last Updated On: August 17th, 2024] [Originally Added On: November 7th, 2010]
- Clear New Insights into the Genetics of Depression [Last Updated On: August 17th, 2024] [Originally Added On: November 7th, 2010]
- TEDMED 2010: Technology and the people [Last Updated On: August 17th, 2024] [Originally Added On: November 7th, 2010]
- Bacteria, the anti-cancer soldier [Last Updated On: August 17th, 2024] [Originally Added On: November 7th, 2010]
- Scientific regress: When science goes backward [Last Updated On: August 17th, 2024] [Originally Added On: February 14th, 2011]
- Can You Live Forever? Maybe Not--But You Can Have Fun Trying [Last Updated On: August 17th, 2024] [Originally Added On: February 14th, 2011]
- How to Fix the Obesity Crisis (preview) [Last Updated On: August 17th, 2024] [Originally Added On: February 14th, 2011]
- Personalizing cancer medicine [Last Updated On: August 17th, 2024] [Originally Added On: February 14th, 2011]
- New Salmonella strain delivers gene-based therapy to fight virus in mice [Last Updated On: August 17th, 2024] [Originally Added On: February 14th, 2011]
- Steps toward a Bionic Eye [Last Updated On: August 17th, 2024] [Originally Added On: February 20th, 2011]
- Giving HIV a Poor Reception: New AIDS Treatment Tinkers with Immune Cell Genes [Last Updated On: August 17th, 2024] [Originally Added On: March 6th, 2011]
- Smaller, cheaper, faster: Does Moore's law apply to solar cells? [Last Updated On: August 17th, 2024] [Originally Added On: March 27th, 2011]
- Smaller, cheaper, faster: Does Moore's law apply to solar cells? [Last Updated On: August 17th, 2024] [Originally Added On: March 27th, 2011]
- New Drugs for Hepatitis C on the Horizon [Last Updated On: August 17th, 2024] [Originally Added On: April 10th, 2011]
- Can we capture all of the world's carbon emissions? [Last Updated On: August 17th, 2024] [Originally Added On: April 10th, 2011]
- Can we capture all of the world's carbon emissions? [Last Updated On: August 17th, 2024] [Originally Added On: April 10th, 2011]
- Drug-resistant genes found in cholera and dysentery strains in New Delhi water supply [Last Updated On: August 17th, 2024] [Originally Added On: May 1st, 2011]
- Fast Track to Vaccines: How Systems Biology Speeds Drug Development (preview) [Last Updated On: August 17th, 2024] [Originally Added On: May 1st, 2011]
- TNVitamins.com – $10 Off Of $50 order [Last Updated On: May 7th, 2011] [Originally Added On: May 7th, 2011]
- 15% Off Any PetAlive Order [Last Updated On: May 7th, 2011] [Originally Added On: May 7th, 2011]
- At PetAlive – $10 off order of $50 or more [Last Updated On: May 7th, 2011] [Originally Added On: May 7th, 2011]
- Native Remedies coupon – 5% Off Any Order [Last Updated On: May 7th, 2011] [Originally Added On: May 7th, 2011]
- Native Remedies – Save $5 coupon [Last Updated On: May 7th, 2011] [Originally Added On: May 7th, 2011]
- Welcome to the Gene Therapy Review [Last Updated On: May 15th, 2011] [Originally Added On: May 15th, 2011]
- Editorial Board [Last Updated On: May 15th, 2011] [Originally Added On: May 15th, 2011]
- Gene Therapy Job Board [Last Updated On: May 15th, 2011] [Originally Added On: May 15th, 2011]
- Corporate Membership [Last Updated On: May 22nd, 2011] [Originally Added On: May 22nd, 2011]
- Native Remedies coupon – 25% Off Any Order [Last Updated On: May 29th, 2011] [Originally Added On: May 29th, 2011]
- What is Gene Therapy? [Last Updated On: June 19th, 2011] [Originally Added On: June 19th, 2011]
- Autism's Tangled Genetics Full of Rare and Varied Mutations [Last Updated On: August 17th, 2024] [Originally Added On: June 19th, 2011]
- Autism's Tangled Genetics Full of Rare and Varied Mutations [Last Updated On: August 17th, 2024] [Originally Added On: June 19th, 2011]
- A New Look at Obsessive-Compulsive Disorder (preview) [Last Updated On: August 17th, 2024] [Originally Added On: June 19th, 2011]
- Close Encounters of Science and Medicine [Last Updated On: August 17th, 2024] [Originally Added On: July 3rd, 2011]
- New Report Details Uphill Battle to Solve the U.S.'s Pain Problem [Last Updated On: August 17th, 2024] [Originally Added On: July 24th, 2011]
- New Report Details Uphill Battle to Solve the U.S.'s Pain Problem [Last Updated On: August 17th, 2024] [Originally Added On: July 24th, 2011]
- A Breath of Fresh Air: New Hope for Cystic Fibrosis Treatment (preview) [Last Updated On: August 17th, 2024] [Originally Added On: August 7th, 2011]
- Studying Mental Illness in a Dish [Last Updated On: August 17th, 2024] [Originally Added On: November 13th, 2011]
- The Puzzle of Pancreatic Cancer: How Steve Jobs Did Not Beat the Oddsbut Nobel Winner Ralph Steinman Did [Last Updated On: August 17th, 2024] [Originally Added On: November 13th, 2011]
- The Puzzle of Pancreatic Cancer: How Steve Jobs Did Not Beat the Odds?but Nobel Winner Ralph Steinman Did [Last Updated On: August 17th, 2024] [Originally Added On: November 13th, 2011]
- Did Alternative Medicine Extend or Abbreviate Steve Jobs's Life? [Last Updated On: August 17th, 2024] [Originally Added On: November 13th, 2011]
- Did Alternative Medicine Extend or Abbreviate Steve Jobs's Life? [Last Updated On: August 17th, 2024] [Originally Added On: November 13th, 2011]
- Calendar: MIND Events in November and December [Last Updated On: August 17th, 2024] [Originally Added On: November 13th, 2011]
- He's No Gregory House--Which Is a Good Thing (preview) [Last Updated On: August 17th, 2024] [Originally Added On: November 20th, 2011]