Hochberg Z, Feil R, Constancia M, Fraga M, Junien C, Carel JC, et al. Child health, developmental plasticity, and epigenetic programming. Endocr Rev. 2011;32:159224.

CAS PubMed Article Google Scholar

Clausen TD, Mathiesen ER, Hansen T, Pedersen O, Jensen DM, Lauenborg J, et al. High prevalence of type 2 diabetes and pre-diabetes in adult offspring of women with gestational diabetes mellitus or type 1 diabetes. Diabetes Care. 2008;31:34036.

PubMed Article Google Scholar

Rijpert M, Evers I, de Vroede MAMJ, de Valk HW, Heijnen CJ, Visser GHA. Risk factors for childhood overweight in offspring of type 1 diabetic women with adequate glycemic control during pregnancy. Diabetes Care. 2009;32:2099104.

PubMed PubMed Central Article Google Scholar

Manderson JG, Mullan B, Patterson CC, Hadden DR, Traub AI, McCance DR. Cardiovascular and metabolic abnormalities in the offspring of diabetic pregnancy. Diabetologia. 2002;45:9916.

CAS PubMed Article Google Scholar

Hjort L, Novakovic B, Grunnet LG, Maple-Brown L, Damm P, Desoye G, et al. Diabetes in pregnancy and epigenetic mechanismshow the first 9 months from conception might affect the childs epigenome and later risk of disease. Lancet Diabetes Endocrinol. 2019;7:796806.

PubMed Article Google Scholar

Illingworth RS, Bird AP. CpG islands--a rough guide. FEBS Lett. 2009;583:171320.

CAS PubMed Article Google Scholar

Szyf M, Bick J. DNA methylation: a mechanism for embedding early life experiences in the genome. Child Dev. 2013;84:4957.

PubMed Article Google Scholar

Jones PA. Functions of DNA methylation: Islands, start sites, gene bodies and beyond. Nat Rev Genet. 2012;13:48492.

CAS PubMed Article Google Scholar

Guo H, Zhu P, Yan L, Li R, Hu B, Lian Y, et al. The DNA methylation landscape of human early embryos. Nature. 2014;511:60610.

CAS PubMed Article Google Scholar

Opsahl JO, Moen GH, Qvigstad E, Bttcher Y, Birkeland KI, Sommer C. Epigenetic signatures associated with maternal body mass index or gestational weight gain: a systematic review. J Dev Orig Health Dis. 2020. https://doi.org/10.1017/S2040174420000811.

Jnsson J, Renault KM, Garca-Calzn S, Perfilyev A, Estampador AC, Nrgaard K, et al. Lifestyle Intervention in Pregnant Women With Obesity Impacts Cord Blood DNA Methylation, Which Associates With Body Composition in the Offspring. Diabetes. 2021;70(4):85466. https://doi.org/10.2337/db20-0487. Epub 2021 Jan 11. PMID: 33431374; PMCID: PMC7980200.

Kelstrup L, Hjort L, Houshmand-Oeregaard A, Clausen TD, Ninna S. Gene expression and DNA methylation of PPARGC1A in muscle and adipose tissue from adult offspring of women with diabetes in pregnancy. Diabetes. 2016;3:141.

Google Scholar

Hjort L, Martino D, Grunnet LG, Naeem H, Maksimovic J. Gestational diabetes and maternal obesity are associated with epigenome-wide methylation changes in children. JCI insight. 2018;3:e122572.

PubMed Central Article Google Scholar

Houshmand-Oeregaard A, Schrlkamp M, Kelstrup L, Hansen NS, Hjort L, Thuesen ACB, et al. Increased expression of microRNA-15a and microRNA-15b in skeletal muscle from adult offspring of women with diabetes in pregnancy. Hum Mol Genet. 2018;27:176371.

CAS PubMed Article Google Scholar

Hansen NS, Strasko KS, Hjort L, Kelstrup L, Houshmand-Regaard A, Schrlkamp M, et al. Fetal hyperglycemia changes human preadipocyte function in adult life. J Clin Endocrinol Metab. 2017;102:114150.

PubMed Article Google Scholar

Houshmand-Oeregaard A, Hansen NS, Hjort L, Kelstrup L, Broholm C, Mathiesen ER, et al. Differential adipokine DNA methylation and gene expression in subcutaneous adipose tissue from adult offspring of women with diabetes in pregnancy. Clin Epigenetics. 2017;9:112.

Article CAS Google Scholar

Houshmand-Oeregaard A, Hjort L, Kelstrup L, Hansen NS, Broholm C, Gillberg L, et al. DNA methylation and gene expression of TXNIP in adult offspring of women with diabetes in pregnancy. PLoS One. 2017;12:118.

Article CAS Google Scholar

Gautier JF, Porcher R, Abi Khalil C, Bellili-Munoz N, Fetita LS, Travert F, et al. Kidney Dysfunction in Adult Offspring Exposed In Utero to Type 1 Diabetes Is Associated with Alterations in Genome-Wide DNA Methylation. PLoS One. 2015;10(8):e0134654. https://doi.org/10.1371/journal.pone.0134654. PMID: 26258530; PMCID: PMC4530883.

Jensen DM, Damm P, Moelsted-Pedersen L, Ovesen P, Westergaard JG, Moeller M, et al. Outcomes in type 1 diabetic pregnancies: a nationwide, population-based study. Diabetes Care. 2004;27:281923.

PubMed Article Google Scholar

Vlachov Z, Bytoft B, Knorr S, Clausen TD, Jensen RB, Mathiesen ER, et al. Increased metabolic risk in adolescent offspring of mothers with type 1 diabetes: the EPICOM study. Diabetologia. 2015;58:145463.

PubMed Article CAS Google Scholar

Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia. 1985;28:4129.

CAS PubMed Article Google Scholar

Aryee MJ, Jaffe AE, Corrada-Bravo H, Ladd-Acosta C, Feinberg AP, Hansen KD, et al. Minfi: a flexible and comprehensive Bioconductor package for the analysis of Infinium DNA methylation microarrays. Bioinformatics. 2014;30:13639.

CAS PubMed PubMed Central Article Google Scholar

Maksimovic J, Gordon L, Oshlack A. SWAN: Subset-quantile within array normalization for illumina infinium HumanMethylation450 BeadChips. Genome Biol. 2012;13:R44.

PubMed PubMed Central Article CAS Google Scholar

Du P, Zhang X, Huang C-C, Jafari N, Kibbe WA, Hou L, et al. Comparison of Beta-value and M-value methods for quantifying methylation levels by microarray analysis. BMC Bioinformatics. 2010;11:587.

CAS PubMed PubMed Central Article Google Scholar

Price ME, Cotton AM, Lam LL, Farr P, Emberly E, Brown CJ, et al. Additional annotation enhances potential for biologically-relevant analysis of the Illumina Infinium HumanMethylation450 BeadChip array. Epigenetics and Chromatin. 2013;6:115.

Article CAS Google Scholar

Houseman EA, Accomando WP, Koestler DC, Christensen BC, Marsit CJ, Nelson HH, et al. DNA methylation arrays as surrogate measures of cell mixture distribution. BMC Bioinformatics. 2012;13:86. https://doi.org/10.1186/1471-2105-13-86. PMID: 22568884; PMCID: PMC3532182.

Smyth GK. limma: Linear Models for Microarray Data. In: Gentleman R, Carey VJ, Huber W, Irizarry RA, Dudoit S, editors. Bioinformatics and Computational Biology Solutions Using R and Bioconductor. Statistics for Biology and Health. New York: Springer; 2005. https://doi.org/10.1007/0-387-29362-0_23.

Peters TJ, Buckley MJ, Statham AL, Pidsley R, Samaras K, Lord RV, et al. De novo identification of differentially methylated regions in the human genome. Epigenetics Chromatin. 2015;8:6. https://doi.org/10.1186/1756-8935-8-6. PMID: 25972926; PMCID: PMC4429355.

Trapnell C, Roberts A, Goff L, Pertea G, Kim D, Kelley DR, et al. Differential gene and transcript expression analysis of RNA-seq experiments with TopHat and Cufflinks. Nat Protoc. 2012;7:56278.

CAS PubMed PubMed Central Article Google Scholar

Anders S, Pyl PT, Huber W. HTSeq-A Python framework to work with high-throughput sequencing data. Bioinformatics. 2015;31:1669.

CAS PubMed Article Google Scholar

Robinson MD, McCarthy DJ, Smyth GK. edgeR: a Bioconductor package for differential expression analysis of digital gene expression data. Bioinformatics. 2010;26(1):13940. https://doi.org/10.1093/bioinformatics/btp616.

CAS Article PubMed Google Scholar

Yu G, Wang LG, Han Y, He QY. ClusterProfiler: an R package for comparing biological themes among gene clusters. Omi A J Integr Biol. 2012;16:2847.

CAS Article Google Scholar

Ren X, Kuan PF. methylGSA: a Bioconductor package and Shiny app for DNA methylation data length bias adjustment in gene set testing. Bioinformatics. 2019;35:19589.

CAS PubMed Article Google Scholar

Gentleman RC, Carey VJ, Bates DM, et al. Bioconductor: open software development for computational biology and bioinformatics. Genome Biol. 2004;5:R80. https://doi.org/10.1186/gb-2004-5-10-r80.

Gentleman R, Carey V, Huber W, Irizarry R, Dudoit S, Smyth GK. Bioinformatics and computational biology solutions using R and Biocunductor; 2015. p. 397420.

Google Scholar

Yu Y, Arah OA, Liew Z, Cnattingius S, Olsen J, Srensen HT, et al. Maternal diabetes during pregnancy and early onset of cardiovascular disease in offspring: population based cohort study with 40 years of follow-up. BMJ. 2019;367 Cvd:14.

Google Scholar

Chavey C, Fajas L. CXCL5 drives obesity to diabetes, and further. Aging (Albany NY). 2009;1:6747.

CAS PubMed PubMed Central Article Google Scholar

Maachi H, Fergusson G, Ethier M, Brill GN, Katz LS, Honig LB, et al. HB-EGF signaling is required for glucose-induced pancreatic -cell proliferation in rats. Diabetes. 2020;69:36980.

CAS PubMed PubMed Central Article Google Scholar

Kos K, Wilding JPH. SPARC: A key player in the pathologies associated with obesity and diabetes. Nat Rev Endocrinol. 2010;6:22535.

CAS PubMed Article Google Scholar

King GL, Park K, Li Q. Selective insulin resistance and the development of cardiovascular diseases in diabetes: The 2015 Edwin Bierman Award Lecture. Diabetes. 2016;65:146271.

CAS PubMed PubMed Central Article Google Scholar

Diz-Villanueva A, Sanz-Pamplona R, Carreras-Torres R, Moratalla-Navarro F, Henar Alonso M, Par-Brunet L, et al. DNA methylation events in transcription factors and gene expression changes in colon cancer. Epigenomics. 2020;12:1593610.

PubMed Article CAS Google Scholar

Prashanth G, Vastrad B, Tengli A, Vastrad C, Kotturshetti I. Identification of hub genes related to the progression of type 1 diabetes by computational analysis. BMC Endocr Disord. 2021;21:165.

Article CAS Google Scholar

Arnaboldi L, Ossoli A, Giorgio E, Pisciotta L, Lucchi T, Grigore L, et al. LIPA gene mutations affect the composition of lipoproteins: enrichment in ACAT-derived cholesteryl esters. Atherosclerosis. 2020;297(2019):815.

CAS PubMed Article Google Scholar

Savill SA, Leitch HF, Harvey JN, Thomas TH. Inflammatory adipokines decrease expression of two high molecular weight isoforms of tropomyosin similar to the change in type 2 diabetic patients. PLoS One. 2016;11:113.

Article CAS Google Scholar

Mazzarotto F, Tayal U, Buchan RJ, Midwinter W, Wilk A, Whiffin N, et al. Reevaluating the genetic contribution of monogenic dilated cardiomyopathy. Circulation. 2020;Dcm:38798.

Article CAS Google Scholar

Zhang SY, Lv Y, Zhang H, Gao S, Wang T, Feng J, et al. Adrenomedullin 2 improves early obesity-induced adipose insulin resistance by inhibiting the class II MHC in adipocytes. Diabetes. 2016;65:234255.

CAS PubMed Article Google Scholar

Fang M, Fan Z, Tian W, Zhao Y, Li P, Xu H, et al. HDAC4 mediates IFN- induced disruption of energy expenditure-related gene expression by repressing SIRT1 transcription in skeletal muscle cells. Biochim Biophys Acta - Gene Regul Mech. 2016;1859:294305.

CAS Article Google Scholar

Merid SK, Novoloaca A, Sharp GC, Kpers LK, Kho AT, Roy R, et al. Epigenome-wide meta-analysis of blood DNA methylation in newborns and children identifies numerous loci related to gestational age. Genome Med. 2020;12:117.

Article CAS Google Scholar

Waterland R, Jirtle RL. Transposable elements: targets for early nutritional effects on epigenetic gene regulation. Mol Cell Biol. 2003;23:5293300.

CAS PubMed PubMed Central Article Google Scholar

Li CCY, Young PE, Maloney CA, Eaton SA, Cowley MJ, Buckland ME, et al. Maternal obesity and diabetes induces latent metabolic defects and widespread epigenetic changes in isogenic mice. Epigenetics. 2013;8:60211.

CAS PubMed PubMed Central Article Google Scholar

Quilter CR, Cooper WN, Cliffe KM, Skinner BM, Prentice PM, Nelson L, et al. Impact on offspring methylation patterns of maternal gestational diabetes mellitus and intrauterine growth restraint suggest common genes and pathways linked to subsequent type 2 diabetes risk. FASEB J. 2014;28:486879.

CAS PubMed Article Google Scholar

Slieker RC, Bos SD, Goeman JJ, Bove JV, Talens RP, van der Breggen R, et al. Identification and systematic annotation of tissue-specific differentially methylated regions using the Illumina 450k array. Epigenetics Chromatin. 2013;6:26.

CAS PubMed PubMed Central Article Google Scholar

Byun HM, Siegmund KD, Pan F, Weisenberger DJ, Kanel G, Laird PW, et al. Epigenetic profiling of somatic tissues from human autopsy specimens identifies tissue- and individual-specific DNA methylation patterns. Hum Mol Genet. 2009;18:480817.

CAS PubMed PubMed Central Article Google Scholar

Fraga MF, Ballestar E, Paz MF, Ropero S, Setien F, Ballestar ML, et al. Epigenetic differences arise during the lifetime of monozygotic twins. Proc Natl Acad Sci U S A. 2005;102:106049.

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