Editor's Choice Main Category: Cancer / Oncology Also Included In: Genetics Article Date: 28 May 2012 - 16:00 PDT

Current ratings for: 'Chronic Inflammation Gene May Destroy Tumors'

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Robert J. Schneider, PhD, the Albert Sabin Professor of Molecular Pathogenesis and associate director for translational research and co-director of the Breast Cancer Program at the NYU Langone Medical Center, who was the principal investigator of the study, declared:

Scientists have known for decades that accelerated ageing, inflammation and cancer are somehow related, yet exactly how these conditions are linked has so far been unknown. The little knowledge available has partly been obtained in Schneider's previous studies, mainly that a gene called AUF1 controls inflammation by switching off the inflammatory response to prevent the onset of septic shock, and although this finding is significant, it fails to shed light on the link to ageing and cancer. The team observed that accelerated ageing occurred when the AUF1 gene was deleted, which led them to investigate further. A decade later, they have finally discovered the link between inflammation, advanced aging and cancer.

They found out that aside from controlling inflammation, AUF1, which belongs to a family of four related genes, also maintains the integrity of chromosomes. It activates telomerase, an enzyme, to repair the ends of chromosomes, and by doing so, it simultaneously reduces inflammation, prevents rapid aging and cancer from developing. Dr. Schneider explained: "AUF1 is a medical and scientific trinity. Nature has designed a way to simultaneously turn off harmful inflammation and repair our chromosomes, thereby suppressing aging at the cellular level and in the whole animal."

Armed with this new discovery, Dr. Schneider and his team are currently researching how the alterations manifest and present themselves clinically. They are examining human populations for specific types of genetic changes in the AUF1 gene, which are associated with rapid ageing, higher risk of cancer and co-developments of certain immune diseases.

Written By Petra Rattue Copyright: Medical News Today Not to be reproduced without permission of Medical News Today

MLA

Petra Rattue. "Chronic Inflammation Gene May Destroy Tumors." Medical News Today. MediLexicon, Intl., 28 May. 2012. Web. 29 May. 2012. <http://www.medicalnewstoday.com/articles/245916.php>

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Chronic Inflammation Gene May Destroy Tumors