In BriefA study published today in the journal Nature confirms earlierreports of the first-ever successful gene-editing of embryos in theU.S. Though controversial, the treatment could one day be used toaddress any of the 10,000 disorders linked to just a single geneticerror. Correcting Mutant Genes

Last week, reports circulated that doctors had successfully edited a gene in a human embryo the first time such a thing had been done in the United States. The remarkable achievement confirmed the powerful potential of CRISPR, the worlds most efficient and effective gene-editing tool. Now, details of the research have been published inNature.

The procedure involved correcting the DNA of one-cell embryos using CRISPRto remove the MYBPC3 gene. That gene is known to cause hypertrophic cardiomyopathy (HCM), a heart disease that affects 1 out of 500 people. HCM has no known cure or treatment as its symptoms dont manifest until the disease causes sudden death through cardiac arrest.

The researchers started with human embryos created from 12 healthy female donors and sperm from a male volunteer who carried the MYBOC3 gene. The defective gene was cut out using CRISPR around the time the sperm was injected into the eggs.

As a result, as the embryos divided and grew, many repaired themselves using the non-edited genes from the genetic materials of the female donors, and in total, 72 percent of the cells that formed appeared to be corrected. The researchers didnt notice any off-target effects on the DNA, either.

The researchers told The Washington Postthat their workwas fairly basic. Really, we didnt edit anything, neither did we modify anything, explained Shoukhrat Mitalipov, lead author and a researcher at the Oregon Health and Science University. Our program is toward correcting mutant genes.

Basicor not, the development is remarkable.By using this technique, its possible to reduce the burden of this heritable disease on the family and eventually the human population, Mitalipov said in an OHSU press release.

However, gene editing is a controversial area of study, and the researchers work included changes to the germ line, meaning the changes could be passed down to future generations. To be clear, though, the embryos were allowed to grow for only a few days and none were implanted into a womb (nor was that ever the researchers intention).

In fact, current legislation in the U.S. prohibits the implantation of edited embryos. Thework conducted by these researchers waswell within the guidelines set by the National Academies of Sciences, Engineering, and Medicine on the use of CRISPR to edit human genes.

University of Wisconsin-Madison bioethicist Alta Charo thinks that the benefits of this potential treatment outweigh all concerns. What this represents is a fascinating, important, and rather impressive incremental step toward learning how to edit embryos safely and precisely, she told The WashingtonPost. [N]o matter what anybody says, this is not the dawn of the era of the designer baby.

Before the technique could be truly beneficial, regulations must be developed that provide clearer guidelines, according to Mitalipov. If not, this technology will be shifted to unregulated areas, which shouldnt be happening, he explained.

More than 10,000 disorders have been linked to just a single genetic error, and as the researchers continue with their work, their next target is BRCA, a gene associated with breast cancer growth.

Mitalipov hopes that their technique could one day be used to treat a wide-range of genetic diseases and save the lives of millions of people. After all, treating a single gene at the embryonic stage is far more efficient that changing a host of them in adults.

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First US Human Embryo Gene Editing Experiment Successfully Corrects a Heart Condition - Futurism