There is no reason to accept ageing as inevitable, Harvard professor Dr David Sinclair said on Friday, adding that if a pill or a vaccine is not developed in the next 30 years to fight ageing, something must have gone terribly wrong.
Dr Sinclair, co-director of the Paul F Glenn Center for Biology of Aging Research at Harvard Medical School, and his team recently turned back the clock on aged eye cells in the retina to reverse vision loss in elderly mice.
Ageing is going to happen We are not going to live forever But can we try to live another 5 or 10 or 20 years longer, healthily? Absolutely... There is no law that says that we couldnt live longer, he said at the 18th Hindustan Times Leadership Summit.
Dr Sinclair, best known for his work on understanding why humans age and how to slow its effects, said it was important to declare ageing as a disease so that governments change laws to treat it with medicines and more funds are accessible for scientific work.
If it [a pill or a vaccine to reverse ageing] doesnt happen in the next 30 years, something must have gone terribly wrong, he said, adding that it was possible a medicine against ageing was already among us. We just need to have more evidence that they actually work the way we are hoping, the Harvard professor, who has featured in TIME magazines list of the 100 most influential people in the world, said.
His research has been primarily focused on sirtuins, a group of proteins that appear to be key in regulating the ageing process. In 1999, he was recruited to the Harvard Medical School, where he has been teaching ageing biology and translational medicine for ageing.
Dr Sinclair also shared tips on how to slow the process of ageing: dont eat three regular meals; exercise; lift some weights; use biomarker feedback; sleep well and reduce stress; and eat plants that have been stressed.
You may not want to skip breakfast, you may want to skip lunch or dinner... its different for every individual. If you are young, this is probably not for you, he said, adding that middle-aged people whose metabolism has slowed down should consider skipping meals strategically.
On the question of whether a vegetarian diet was better or a non-vegetarian regimen, he said: You do want your diet to look like what a rabbit might eat more than a lion.
According to a paper published in Nature, Dr Sinclair and his team used an adeno-associated virus as a vehicle to deliver into the retinas of mice three youth-restoring genes that are normally switched on during embryonic development. The three genes, together with a fourth one that was not used in this work, are collectively known as Yamanaka factors. This promoted nerve regeneration following optic-nerve injury in mice with damaged optic nerves, reversed vision loss in animals with a condition mimicking human glaucoma, and reversed vision loss in ageing animals without glaucoma.
Dr Sinclair said on Friday: We are trying to understand can we compress the last few years of life that are sick into a very short period... [The goal] is really not to keep us in nursing homes and being sick for longer. We are not extending old age, we are doing the opposite. Our goal is to extend youthfulness so that we can perhaps live to 90 or 100 and towards the very end, still be productive members of society playing whatever sport you want with your grandkids or great grandkids.
He added: Often, we think that we have reached our maximum life span as a society... that is not true... Over the 20th Century and continuing to today, there is a very linear and predictable increase in human longevity. Every time [people] have said that we have reached the maximum, we blow through that glass ceiling and we keep adding years to life. But they are not all healthy years.
The expert also gave more insights on mortality as a route to tackling ageing. We tend not to die as much as we used to from cardiac reasons, but the brain still ages at the normal rate and we dont do much about it Our approach is to treat the entire body with medicines and lifestyles that will keep every part of the body healthier and more youthful, the expert added. In my scientific opinion, around the age of 30, ageing starts to kick in.
On being asked about the nature of supplements people should take in the quest to slow ageing, the he said: Go with a company that has a good reputation Go for the very pure molecules. He added that resveratrol, a chemical found in red wine, appeared to show benefits in terms of anti-ageing properties. He, however, said that right meals and exercise seem to be the best bet against ageing at this point.
The proof-of-concept study published in Nature demonstrates the epigenetic reprogramming of complex tissues, such as the nerve cells of the eye, to a younger age when they can repair and replace tissue damaged from age-related conditions and diseases. Elaborating on the study in mice, Dr Sinclair said that most of our longevity is determined by our epigenome and not by our DNA.
While the DNA holds instructions for building proteins, epigenome comprises all of chemicals that are added to ones DNA to regulate the activity.
See original here:
Pill to reverse ageing in 30 years? Why not, says Harvard professor Dr David Sinclair - Hindustan Times
- Scientists believe that aging might be optional - Mail Herald [Last Updated On: August 18th, 2024] [Originally Added On: November 18th, 2019]
- This Week in Running: November 18, 2019 - iRunFar [Last Updated On: August 18th, 2024] [Originally Added On: November 21st, 2019]
- Aging as a preventable disease and why living to 100 should be easy - Genetic Literacy Project [Last Updated On: August 18th, 2024] [Originally Added On: November 21st, 2019]
- David Sinclair on Joe Rogan Podcast - chatting about NMN and ... [Last Updated On: August 18th, 2024] [Originally Added On: November 23rd, 2019]
- NMN and NAD Reverse Aging of Blood Vessels in New Study [Last Updated On: August 18th, 2024] [Originally Added On: November 23rd, 2019]
- #70 - David Sinclair, Ph.D.: How cellular reprogramming could ... [Last Updated On: August 18th, 2024] [Originally Added On: November 23rd, 2019]
- Lifespan: Why We Age_and Why We Don't Have To: David A ... [Last Updated On: August 18th, 2024] [Originally Added On: November 23rd, 2019]
- David Sinclair supplements and protocol explained NMN ... [Last Updated On: August 18th, 2024] [Originally Added On: November 23rd, 2019]
- David Sinclair's biological age was 58 after taking 1000 mg ... [Last Updated On: August 18th, 2024] [Originally Added On: November 23rd, 2019]
- David Sinclairs anti-aging science | Harvard Magazine [Last Updated On: August 18th, 2024] [Originally Added On: November 23rd, 2019]
- David Sinclair Supplements For Anti-Aging - What He Takes & Why [Last Updated On: August 18th, 2024] [Originally Added On: November 23rd, 2019]
- What Does David Sinclair Eat and Supplement? (2019 ... [Last Updated On: August 18th, 2024] [Originally Added On: November 23rd, 2019]
- #27 - David Sinclair, Ph.D.: Slowing aging sirtuins, NAD ... [Last Updated On: August 18th, 2024] [Originally Added On: November 23rd, 2019]
- Man with string of convictions in his native Poland came to Perth to set up drug den - The Courier [Last Updated On: August 18th, 2024] [Originally Added On: November 30th, 2019]
- Last surviving Viking-inspired boat that served a now- abandoned island goes up for auction - The Scotsman [Last Updated On: August 18th, 2024] [Originally Added On: November 30th, 2019]
- Dealer Jailed After Raid Uncovers 44k of Grugs - Daily Record [Last Updated On: August 18th, 2024] [Originally Added On: November 30th, 2019]
- Lazarus Effect: Sixteen-year study by Dr. Leis resulted in recovery from West Nile for Dr. Bush - Northside Sun [Last Updated On: August 18th, 2024] [Originally Added On: December 21st, 2019]
- OZY Takes You Ahead of the Curve in Science and Technology - OZY [Last Updated On: August 18th, 2024] [Originally Added On: December 29th, 2019]
- The Race To Find A Cure For Aging - Medium [Last Updated On: August 18th, 2024] [Originally Added On: January 1st, 2020]
- Hard work and dedication honored - Union Daily Times [Last Updated On: August 18th, 2024] [Originally Added On: January 23rd, 2020]
- Meet the people who think soaking in a frozen Minneapolis lake is the secret to good health - Minneapolis Star Tribune [Last Updated On: August 18th, 2024] [Originally Added On: January 24th, 2020]
- BOYS SWIMMING: Tigersharks top Waconia in conference dual - Crow River Media [Last Updated On: August 18th, 2024] [Originally Added On: January 25th, 2020]
- David Sinclair on NMN and Epigenetics | | LEAF [Last Updated On: August 18th, 2024] [Originally Added On: January 25th, 2020]
- Brave Cashel Community School get the better of St Augustine's to set-up a Munster hurling final clash with Doon - TipperaryLive.ie [Last Updated On: August 18th, 2024] [Originally Added On: January 28th, 2020]
- Diane Francis: Treating aging like a disease is the next big thing for science - Financial Post [Last Updated On: August 18th, 2024] [Originally Added On: January 28th, 2020]
- Letter: Yes to Green Growth | Opinion - Southern Pines Pilot [Last Updated On: August 18th, 2024] [Originally Added On: January 28th, 2020]
- Kelty Hearts 4-1 Caledonian Braves: Third straight defeat for Braves - Motherwell Times [Last Updated On: August 18th, 2024] [Originally Added On: February 6th, 2020]
- Is soaking in a frozen lake the secret to good health? - The Detroit News [Last Updated On: August 18th, 2024] [Originally Added On: February 12th, 2020]
- Letter:Deputy Is Vindicated | Opinion - Southern Pines Pilot [Last Updated On: August 18th, 2024] [Originally Added On: February 12th, 2020]
- BOYS SWIMMING: Chargers take fifth at WCC Championships; look ahead to sections - Crow River Media [Last Updated On: August 18th, 2024] [Originally Added On: February 12th, 2020]
- Lifespan: The New Science Behind Anti-Aging and Longevity that Can Help You Live to 100 - Thrive Global [Last Updated On: August 18th, 2024] [Originally Added On: February 19th, 2020]
- Not fasting is killing us, but fasting can hurt us too. Here's what to do. - Mashable [Last Updated On: August 18th, 2024] [Originally Added On: February 21st, 2020]
- Anti-Aging Researcher David Sinclair Takes Metformin, NMN ... [Last Updated On: August 18th, 2024] [Originally Added On: February 22nd, 2020]
- Movers and Shakers Week Ending 2.28.20 - milehighcre.com [Last Updated On: August 18th, 2024] [Originally Added On: February 28th, 2020]
- Health inequality in England was bad. It has got worse - The Economist [Last Updated On: August 18th, 2024] [Originally Added On: February 28th, 2020]
- Southland couple join volunteers to help future proof Southland A&P Show - Stuff.co.nz [Last Updated On: August 18th, 2024] [Originally Added On: March 3rd, 2020]
- Pilot Wins Top Honors at Awards Ceremony | Business - Southern Pines Pilot [Last Updated On: August 18th, 2024] [Originally Added On: March 3rd, 2020]
- Flipping the switch on the ageing process - The Age [Last Updated On: August 18th, 2024] [Originally Added On: March 21st, 2020]
- 7 books to read while in coronavirus quarantine or isolation - The CEO Magazine [Last Updated On: August 18th, 2024] [Originally Added On: March 28th, 2020]
- Remembering loved ones who have passed away - the 68 death notices in North Staffordshire this week - Stoke-on-Trent Live [Last Updated On: August 18th, 2024] [Originally Added On: March 31st, 2020]
- Can canine coronavirus drug indomethacin be used in treating humans suffering from COVID-19? - MEAWW [Last Updated On: August 18th, 2024] [Originally Added On: April 11th, 2020]
- Is There Any Legitimate Health Advice in Gwyneth Paltrow's "Goop Lab"? - InsideHook [Last Updated On: August 18th, 2024] [Originally Added On: April 11th, 2020]
- Will Universities, Colleges, And Law School Campuses Be Open In Fall 2020? - Above the Law [Last Updated On: August 18th, 2024] [Originally Added On: April 11th, 2020]
- 'Refreshingly honest' dealer who ran Perth drug den will be sent home to Poland - The Courier [Last Updated On: August 18th, 2024] [Originally Added On: April 14th, 2020]
- Has Harvard's David Sinclair Found the Fountain of Youth? [Last Updated On: August 18th, 2024] [Originally Added On: April 20th, 2020]
- Carole Carson: Adventures in Aging Seven myths about getting older - The Union of Grass Valley [Last Updated On: August 18th, 2024] [Originally Added On: April 25th, 2020]
- Hide and Hedonism invite guests to a virtual wine dinner - Spear's WMS [Last Updated On: August 18th, 2024] [Originally Added On: May 1st, 2020]
- Budget realities from COVID-19 cut $40.6 million from Prince William budgets - Inside NoVA [Last Updated On: August 18th, 2024] [Originally Added On: May 1st, 2020]
- Drug Use is Transmitted from Old to Young - UPJ Athletics [Last Updated On: August 18th, 2024] [Originally Added On: May 16th, 2020]
- Fife woman breached Asbo by having illicit party at home during lockdown - The Courier [Last Updated On: August 18th, 2024] [Originally Added On: May 19th, 2020]
- A Harvard Geneticist Wants To Sell A Magical ... - HuffPost [Last Updated On: August 18th, 2024] [Originally Added On: June 9th, 2020]
- Jennifer Aniston: How The Morning Show felt like 20 years of therapy - The Detroit News [Last Updated On: August 18th, 2024] [Originally Added On: August 26th, 2020]
- Woods, Waters, and Wildlife: Buy Licenses Now! | FCT News - Freestonecountytimesonline [Last Updated On: August 18th, 2024] [Originally Added On: August 29th, 2020]
- Editorial: Five Birdies That Signal Good Work | Opinion | thepilot.com - Southern Pines Pilot [Last Updated On: August 18th, 2024] [Originally Added On: September 3rd, 2020]
- We all suffer when COVID-19 locks the elderly out of societal participation - The Investment Observer [Last Updated On: August 18th, 2024] [Originally Added On: September 18th, 2020]
- Immetas Therapeutics Announces Series A Financing to Advance Research on Inflammation Pathways in Aging and Develop Therapeutics for Cancer and... [Last Updated On: August 18th, 2024] [Originally Added On: September 26th, 2020]
- DS4 to rock Morden live at The Sound Lounge - Your Local Guardian [Last Updated On: August 18th, 2024] [Originally Added On: September 26th, 2020]
- How newly unemployed over-50s can start-up again - The Guardian [Last Updated On: August 18th, 2024] [Originally Added On: October 8th, 2020]
- 100 years old will be the new 60 | Health & Wellness - CL Charlotte [Last Updated On: August 18th, 2024] [Originally Added On: October 16th, 2020]
- Brexit casts doubt over UK pension rights - Interactive Investor [Last Updated On: August 18th, 2024] [Originally Added On: October 16th, 2020]
- Cancer. How close are we to winning the war? - Switzer [Last Updated On: August 18th, 2024] [Originally Added On: October 16th, 2020]
- Where Sabrina the Teenage Witch cast are now - hit TV shows and unrecognisable star - Mirror Online [Last Updated On: August 18th, 2024] [Originally Added On: October 28th, 2020]
- Caledonian Braves can 'breathe a bit easier' after first win says boss Ricky Waddell - MSN UK [Last Updated On: August 18th, 2024] [Originally Added On: October 28th, 2020]
- Why Aren't We Talking More About Nutrition Amid COVID-19? - Anti Aging News [Last Updated On: August 18th, 2024] [Originally Added On: November 2nd, 2020]
- We should allow ourselves to be #pharmaproud - - pharmaphorum [Last Updated On: August 18th, 2024] [Originally Added On: November 19th, 2020]
- 6 Anti Aging Benefits of Metformin - The Shepherd of the Hills Gazette [Last Updated On: August 18th, 2024] [Originally Added On: November 19th, 2020]
- Hokitika father charged with murder initially claimed son fell out of bed - Stuff.co.nz [Last Updated On: August 18th, 2024] [Originally Added On: November 19th, 2020]
- Scientists Uncover Approach That Could Reverse Age-Related Vision Loss - Science Times [Last Updated On: August 18th, 2024] [Originally Added On: December 6th, 2020]
- HTLS 2020: A pill that can reverse ageing? Yes, it will be possible, says Dr Sinclair - Hindustan Times [Last Updated On: August 18th, 2024] [Originally Added On: December 6th, 2020]
- Reversing vision loss by turning back the aging clock - FierceBiotech [Last Updated On: August 18th, 2024] [Originally Added On: December 6th, 2020]
- Get younger reverse ageing and increase your health span - Have a Go News [Last Updated On: August 18th, 2024] [Originally Added On: December 8th, 2020]
- Over 50s Spending Spree Boosts Economy By Billions - Money International [Last Updated On: August 18th, 2024] [Originally Added On: January 20th, 2021]
- Hunger in Milwaukee and the World: What We Can Do About It - Wisconsin Public Radio News [Last Updated On: August 18th, 2024] [Originally Added On: February 15th, 2021]
- Woman's 'nasty' skin infection most likely caused by swimming in sea after shaving legs - Stuff.co.nz [Last Updated On: August 18th, 2024] [Originally Added On: August 3rd, 2021]
- David Sinclair | The Sinclair Lab [Last Updated On: August 18th, 2024] [Originally Added On: December 21st, 2021]
- David Sinclair Supplements List Deep Dive - Updated 2021 [Last Updated On: August 18th, 2024] [Originally Added On: December 21st, 2021]
- Don't Listen to Intermittent Fasting Influencers, The Science Doesn't Back It Up - InsideHook [Last Updated On: August 18th, 2024] [Originally Added On: April 27th, 2022]
- David Sinclair Post-2022 Canyons by UTMB 100k Interview - iRunFar [Last Updated On: August 18th, 2024] [Originally Added On: April 27th, 2022]
- Authorized Biography Of The Rolling Stones Charlie Watts Launched In London - uDiscover Music [Last Updated On: August 18th, 2024] [Originally Added On: September 24th, 2022]
- David Sinclair Supplements (2022 List) | Brands for Anti-Aging! [Last Updated On: August 18th, 2024] [Originally Added On: September 24th, 2022]