A team of neuroscientists at the University of Wisconsin claim to have found a way to control how high mice can get on a given amount of cocaine.

And don't worry — while that may sound like a particularly frivolous plot concocted by a team of evil scientists, the goal of the research is well-meaning.

The team, led by University of Wisconsin neuroscientist Santiago Cuesta, was investigating how the gut microbiome can influence how mice and humans react to ingesting the drug.

The research, detailed in a new paper published this week in the journal Cell Host & Microbe, sheds light on a vicious feedback loop that could explain cases of substance abuse disorders — and possibly lay the groundwork for future therapeutic treatments.

In a number of experiments on mice, the researchers found that cocaine was linked to the growth of common gut bacteria, which feed on glycine, a chemical that facilitates basic brain functions.

The lower the levels of glycine in the brain, the more the mice reacted to the cocaine, exhibiting abnormal behaviors.

To test the theory, the scientists injected the mice with a genetically modified amino acid which cannot break down glycine. As a result, the behavior of mice returned to normal levels.

In other words, the amino acid could curb cocaine addiction-like behaviors — at least in animal models.

"The gut bacteria are consuming all of the glycine and the levels are decreasing systemically and in the brain," said Vanessa Sperandio, senior author, and microbiologist from the University of Wisconsin, in a statement. "It seems changing glycine overall is impacting the glutamatergic synapses that make the animals more prone to develop addiction."

It's an unorthodox approach to treating addiction, but could be intriguing — if it works in people, that is.

"Usually, for neuroscience behaviors, people are not thinking about controlling the microbiota, and microbiota studies usually don't measure behaviors, but here we show they’re connected," Cuesta added. "Our microbiome can actually modulate psychiatric or brain-related behaviors."

In short, their research could lead to new ways of treating various psychiatric disorders such as substance use by adjusting the gut microbiome and not making changes to the brain chemistry.

"I think the bridging of these communities is what's going to move the field forward, advancing beyond correlations towards causations for the different types of psychiatric disorders," Sperandio argued.

READ MORE: How gut bacteria influence the effects of cocaine in mice [Cell Press]

More on addiction: Study: Magic Mushrooms Helped 83% of People Cut Excessive Drinking

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Scientists Found a Way to Control How High Mice Got on Cocaine

Observatory Offline

The Atacama Large Millimeter Array (ALMA) Observatory in Chile has been hit with a cyberattack that has taken its website offline and forced it to suspend all observations, authorities there said.

Even email services were limited in the aftermath, illustrating the broad impact of the hack.

Nested high up on a plateau in the Chilean Andes at over 16,000 feet above sea level, ALMA is one of the most powerful and advanced radio telescopes in the world. Notably, ALMA helped take the first image of a black hole in 2019, in a collaborative effort that linked radio observatories worldwide into forming the Event Horizon Telescope.

Thankfully, ALMA's impressive arsenal of 66 high-precision antennas, each nearly 40 feet in diameter, was not compromised, the observatory said, nor was any of the scientific data those instruments collected.

In High Places

What makes ALMA so invaluable is its specialty in observing the light of the cooler substances of the cosmos, namely gas and dust. That makes ALMA a prime candidate for documenting the fascinating formations of planets and stars when they first emerge amidst clouds of gas.

Since going fully operational in 2013, it's become the largest ground-based astronomical project in the world, according to the European Southern Observatory, ALMA's primary operators.

So ALMA going offline is a distressing development, especially to the thousands of astronomers worldwide that rely on its observations and the some 300 experts working onsite. Getting it up and running is obviously a top priority, but the observatory said in a followup tweet that "it is not yet possible to estimate a date for a return to regular activities."

As of now, there's no information available on who the hackers were, or exactly how they conducted the attack. Their motivations, too, remain a mystery.

More on ALMA: Astronomers Think They Found the Youngest Planet in the Galaxy

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Hackers Just Took Down One of the World's Most Advanced Telescopes

Advertisers are fleeing Twitter in droves now that Tesla and SpaceX CEO Elon Musk has taken over control.

Ever since officially closing the $44 billion deal, Musk has been busy gutting the company's executive suite and dissolving its board. Senior executives, as well as Twitter's advertising chief Sarah Personette, have departed as well.

After all, Musk has been very clear about his disdain for advertising for years now.

The resulting uncertainty has advertisers spooked — major advertising holding company IPG has already advised clients to pull out temporarily — and the billionaire CEO is in serious damage mode.

Now, Reuters reports, Musk is spending most of this week meeting with advertisers in New York, trying to reassure them that Twitter won't turn into a "free-for-all hellscape."

According to one of Reuters' sources, the meetings have been "very productive" — but plenty of other marketers are far from satisfied.

Advertisers are reportedly grilling Musk over his plans to address the rampant misinformation being spread on the platform, a trend that Musk himself has been actively contributing to since the acquisition.

And if he's succeeding in ameliorating advertisers in private, he's antagonizing them publicly. On Wednesday, Musk posted a poll asking users whether advertisers should support either "freedom of speech," or "political 'correctness'" — a type of false dichotomy that echoes the rhetoric of far-right conspiracy theorists and conservative pundits.

"Those type of provocations are not helping to calm the waters," an unnamed media buyer told Reuters.

Some are going public with the same sentiment.

"Unless Elon hires new leaders committed to keeping this 'free' platform safe from hate speech, it's not a platform brands can/should advertise on," Allie Wassum, global media director for the Nike-owned shoe brand Jordan, wrote in a LinkedIn post.

So far, Musk's plans for the social media platform remain strikingly muddy. In addition to the behind-the-scenes advertising plays, he's also announced that users will have to pay to retain their verification badge, though he's engaged in a comically public negotiation as to what the cost might be.

He's also hinted that previously banned users — former US president Donald Trump chief among them — might eventually get a chance to return, but only once "we have a clear process for doing so, which will take at least a few more weeks."

The move was seen by many as a way to wait out the impending midterm elections. After all, Twitter has played a huge role in disseminating misinformation and swaying elections in the past.

While advertisers are running for the hills, to Musk advertising is clearly only a small part of the picture — even though historically, social giants like Twitter have struggled to diversify their revenue sources much beyond display ads.

Musk nodded to that reality in a vague open letter posted last week.

"Low relevancy ads are spam, but highly relevant ads are actually content!" he wrote in the note, addressed to "Twitter advertisers."

Big picture, Twitter's operations are in free fall right now and Musk has yet to provide advertisers with a cohesive plan to pick up the pieces.

While he's hinted at the creation of a new content moderation council made up of both "people from all viewpoints" and "wildly divergent views," advertisers are clearly going to be thinking twice about continuing their business with Twitter.

With or without advertising, Twitter's finances are reportedly in a very deep hole. The billions of dollars Musk had to borrow to finance his mega acquisition will cost Twitter around $1 billion a year in interest alone.

The company also wasn't anywhere near profitable before Musk took over, losing hundreds of millions of dollars in a single quarter.

Whether that picture will change any time soon is as unclear as ever, especially in the face of a wintry economy.

But, of course, Musk has proved his critics wrong before. So anything's possible.

READ MORE: Advertisers begin to grill Elon Musk over Twitter 'free-for-all' [Reuters]

More on the saga: Elon Musk Pulling Engineers From Tesla Autopilot to Work on Twitter

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Elon Musk Meeting With Advertisers, Begging Them Not to Leave Twitter

Chinese scientists are reportedly planning to send monkeys to its new Tiangong space station for experiments that will involve the animals mating and potentially reproducing, the South China Morning Post reports.

It's a fascinating and potentially controversial experiment that could have major implications for our efforts to colonize space: can mammals, let alone humans, successfully reproduce beyond the Earth?

According to the report, the experiment would take place in the station's largest capsule, called Wentian, inside two biological test cabinets that can be expanded.

After examining the behavior of smaller creatures, "some studies involving mice and macaques will be carried out to see how they grow or even reproduce in space," Zhang Lu, a researcher at the Chinese Academy of Sciences in Beijing, said during a speech posted to social media earlier this week, as quoted by the SCMP.

"These experiments will help improve our understanding of an organism’s adaptation to microgravity and other space environments," he added.

Some simpler organisms, including nematodes and Japanese rice fish, have been observed reproducing in space.

But more complex life forms have struggled. In 2014, a Russian experiment to see whether geckos could produce offspring in space failed when all the critters died.

And the failure rate for mammals, so far, has been total. Soviet Union scientists got mice to mate during a space flight in 1979, but none of them gave birth after being returned to Earth.

In other words, getting monkeys to reproduce on board a space station will be anything but easy. For one, just dealing with living creatures in space can pose immense challenges. The astronauts will "need to feed them and deal with the waste," Kehkooi Kee, a professor with the school of medicine at Tsinghua University, told the SCMP.

Then there's the fact that astronauts will have to keep the macaques happy and comfortable, something that experts say will be challenging since long term confinement in the spartan environments of space habitats could cause immense stress for the simians.

And even if astronauts successfully set the mood for the monkeys, the physics of sex in space are predicted to be challenging.

"Firstly, just staying in close contact with each other under zero gravity is hard," Adam Watkins, an associate professor of reproductive physiology at University of Nottingham, wrote in a 2020 open letter highlighted by the SCMP. "Secondly, as astronauts experience lower blood pressure while in space, maintaining erections and arousal are more problematic than here on Earth."

With its new space station in nearly full operation, China isn't shying away from asking some big questions — but whether these experiments will play out as expected is anything but certain.

READ MORE: Chinese scientists plan monkey reproduction experiment in space station [South China Morning Post]

More on sex in space: Scientists Say We Really Have to Talk About Boning in Space

The post China Plans to Send Monkeys to Space Station to Have Sex With Each Other appeared first on Futurism.

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China Plans to Send Monkeys to Space Station to Have Sex With Each Other

Latest Feud

Another day, another Elon Musk feud on Twitter — except now, he's the owner of the social network, and he's beefing with a sitting member of Congress.

The whole thing started innocently enough earlier this week, when firebrand Rep. Alexandria Ocasio-Cortez (D-NY, and better known by her initials, "AOC") subtweeted the website's new owner.

"Lmao at a billionaire earnestly trying to sell people on the idea that 'free speech' is actually a $8/mo subscription plan," the New York Democratic Socialist tweeted in a post that, upon Futurism's perusal, appeared to load only half the time.

Sweat Equity

Not one to be shown up, Musk later posted a screenshot of an AOC-branded sweatshirt from the congressperson's website, with its $58 price tag circled and an emoji belying the billionaire's alleged affront at the price.

In response, Ocasio-Cortez said she was proud her sweatshirts were made by union labor, and that the proceeds from their sales were going to fund educational support for needy kids. She later dug in further, noting that her account was "conveniently" not working and joking that Musk couldn't buy his way "out of insecurity."

Yo @elonmusk while I have your attention, why should people pay $8 just for their app to get bricked when they say something you don’t like?

This is what my app has looked like ever since my tweet upset you yesterday. What’s good? Doesn’t seem very free speechy to me pic.twitter.com/e3hcZ7T9up

— Alexandria Ocasio-Cortez (@AOC) November 3, 2022

Bricked

To be clear, any suggestion that Musk personally had anything to do with any Twitter glitches on AOC's part would seem ludicrously petty. But then again, this is a guy who once hired a private detective to investigate a random critic.

Occam's razor, though, suggests that it was probably AOC's mega-viral tweet that broke the site's notoriously dodgy infrastructure. Of course, that's not a ringing endorsement of the site that Musk just acquired for the colossal sum of $44 billion.

More on Twitter: Twitter Working on Plan to Charge Users to Watch Videos

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AOC Says Her Twitter Account Broke After She Made Fun of Elon Musk

You know that "research" going around saying humans are going to evolve to have hunchbacks and claws because of the way we use our smartphones? Though our posture could certainly use some work, you'll be glad to know that it's just lazy spam intended to juice search engine results.

Let's back up. Today the Daily Mail published a viral story about "how humans may look in the year 3000." Among its predictions: hunched backs, clawed hands, a second eyelid, a thicker skull and a smaller brain.

Sure, that's fascinating! The only problem? The Mail's only source is a post published a year ago by the renowned scientists at... uh... TollFreeForwarding.com, a site that sells, as its name suggests, virtual phone numbers.

If the idea that phone salespeople are purporting to be making predictions about human evolution didn't tip you off, this "research" doesn't seem very scientific at all. Instead, it more closely resembles what it actually is — a blog post written by some poor grunt, intended to get backlinks from sites like the Mail that'll juice TollFreeForwarding's position in search engine results.

To get those delicious backlinks, the top minds at TollFreeForwarding leveraged renders of a "future human" by a 3D model artist. The result of these efforts is "Mindy," a creepy-looking hunchback in black skinny jeans (which is how you can tell she's from a different era).

Grotesque model reveals what humans could look like in the year 3000 due to our reliance on technology

Full story: https://t.co/vQzyMZPNBv pic.twitter.com/vqBuYOBrcg

— Daily Mail Online (@MailOnline) November 3, 2022

"To fully realize the impact everyday tech has on us, we sourced scientific research and expert opinion on the subject," the TollFreeForwarding post reads, "before working with a 3D designer to create a future human whose body has physically changed due to consistent use of smartphones, laptops, and other tech."

Its sources, though, are dubious. Its authority on spinal development, for instance, is a "health and wellness expert" at a site that sells massage lotion. His highest academic achievement? A business degree.

We could go on and on about TollFreeForwarding's dismal sourcing — some of which looks suspiciously like even more SEO spam for entirely different clients — but you get the idea.

It's probably not surprising that the this gambit for clicks took off among dingbats on Twitter. What is somewhat disappointing is that it ended up on StudyFinds, a generally reliable blog about academic research. This time, though, for inscrutable reasons it treated this egregious SEO spam as a legitimate scientific study.

The site's readers, though, were quick to call it out, leading to a comically enormous editor's note appended to the story.

"Our content is intended to stir debate and conversation, and we always encourage our readers to discuss why or why not they agree with the findings," it reads in part. "If you heavily disagree with a report — please debunk to your delight in the comments below."

You heard them! Get debunking, people.

More conspiracy theories: If You Think Joe Rogan Is Credible, This Bizarre Clip of Him Yelling at a Scientist Will Probably Change Your Mind

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That "Research" About How Smartphones Are Causing Deformed Human Bodies Is SEO Spam, You Idiots

What do Intel and the U.S. federal government have in common? Neither of them has a supercomputer. And thats because Intels ability to build a 4th generation Xeon Sapphire Rapids super processor keeps getting set back, most recently when it was revealed the chip had 500 bugs the company needed to fix.

The Sapphire Rapids chips have been delayed several times over the past two years with no reasons given. Then, last week, computing watchdog site Igors Lab revealed Intel was working on 500 bugs that required 12 steppings to fix them. Ouch.

The Sapphire Rapids processor increases core count to 60 and brings Advanced Matrix Extensions (AME), Data Streaming Acceleration (DSA), and HBM2E memory support. Put mildly, the chip is a next-generation monster of a processor designed to work with so-called supercomputers.

But 500 bugs requiring 12 steppings is a monster of a project to fix. Steppings are a system used by Intel to identify the changes to a unit. They consist of a letter and a number, such as A2. A number change means a minor fix or adjustment was made, while a letter change means an extensive design overhaul was made. The Sapphire Rapids bugs require three letter changes and nine number changes.

Intels scalable data center CPU has been in the works for several years as part of a large contract with the United States Department of Energy (DoE) to build the Aurora supercomputer, a massive data center able to handle the governments vast computing needs without the need for third-party cloud vendors, such as Microsoft Azure and Amazon Web Services. The government unveiled contracts for three supercomputers in 2019.

Two of them are hybrid computers built by AMD and HP. The Aurora is the only fully Intel-built computer in the contract. None of them are operational yet, although the AMD/HP computers have been built and are going through testing. Its the Intel-only Aurora that is holding the project back.

These Intel chips were due in the first quarter of this year after one and a half years of setbacks. It now looks as if the US government will have to wait a lot longer.

Continue reading here:

Intel has 500 bugs to fix in its next supercomputer chips - Digital Trends

Liverpool have been backed to pip Manchester City to the Premier League title ahead of the 2022/23 campaign.

This update comes from Optas predictor modelon Twitter, with the Reds having a 49.7% chance of snatching the top-flight crown away from the current incumbents who have been given a 47% chance of retaining it.

The Merseysiders came achingly close to completing a domestic treble but fell short of the league title by a point as a resurgent Sky Blues outfit completed a terrific comeback against Steven Gerrards Aston Villa on the final day of the season.

Though the use of data in football has unquestionably become more commonplace, one always has to take season predictors with a pinch of salt.

You can vaguely assume that ourselves and Pep Guardiolas men will be at the top of the pile albeit, perhaps a little less clear of the chasing pack behind following good windows for the likes of Tottenham and Co. though with such fine margins separating the two, the race could come down to injuries, silly draws or having key men at home during the winter period whilst the World Cup is on.

After what was an emotionally as well as physically draining campaign for Mo Salah in particular, the potentially positive impact of a second pre-season period, as Jurgen Klopp would refer to it, cant be discounted in what will most likely be another closely fought title race.

#Ep56 of The Empire of the Kop Podcast: Nunez silences critics! Firmino to start v Man City? & more!

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New supercomputer has predicted 2.7% chance between Liverpool and City for the PL title - Yardbarker

One aspect of Nancy Pelosis trip to Taiwan that has been largely overlooked is her meeting with Mark Lui, chairman of the Taiwan Semiconductor Manufacturing Corporation (TSMC). Pelosis trip coincided with US efforts to convince TSMC the worlds largest chip manufacturer, on which the US is heavily dependent to establish a manufacturing base in the US and to stop making advanced chips for Chinese companies.

US support for Taiwan has historically been based on Washingtons opposition to communist rule in Beijing, and Taiwans resistance to absorption by China. But in recent years, Taiwans autonomy has become a vital geopolitical interest for the US because of the islands dominance of the semiconductor manufacturing market.

Semiconductors also known as computer chips or just chips are integral to all the networked devices that have become embedded into our lives. They also have advanced military applications.

Transformational, super-fast 5G internet emerged is enabling a world of connected devices of every kind (the Internet of Things) and a new generation of networked weapons. With this in mind, US officials began to realise during the Trump administration that US semiconductor design companies, such as Intel, were heavily dependent on Asian-based supply chains for the manufacturing of their products.

In particular, Taiwans position in the world of semiconductor manufacturing is a bit like Saudi Arabias status in OPEC. TSMC has a 53% market share of the global foundry market (factories contracted to make chips designed in other countries). Other Taiwan-based manufacturers claim a further 10% of the market.

As a result, the Biden administrations 100-Day Supply Chain Review Report says, The United States is heavily dependent on a single company TSMC for producing its leading-edge chips. The fact that only TSMC and Samsung (South Korea) can make the most advanced semiconductors (known as five nanometres) puts at risk the ability to supply current and future [US] national security and critical infrastructure needs .

This means that Chinas long-term goal of reunifying with Taiwan is now more threatening to US interests. In the 1971 Shanghai Communique and the 1979 Taiwan Relations Act, the US recognised that people in both mainland China and Taiwan believed that there was One China and that they both belonged to it. But for the US it is unthinkable that TSMC could one day be in territory controlled by Beijing.

For this reason, the US has been trying to attract TSMC to the US to increase domestic chip production capacity. In 2021, with the support of the Biden administration, the company bought a site in Arizona on which to build a US foundry. This is scheduled to be completed in 2024.

The US Congress has just passed the Chips and Science Act, which provides US$52 billion (43 billion) in subsidies to support semiconductor manufacturing in the US. But companies will only receive Chips Act funding if they agree not to manufacture advanced semiconductors for Chinese companies.

This means that TSMC and others may well have to choose between doing business in China and in the US because the cost of manufacturing in the US is deemed to be too high without government subsidies.

This is all part of a broader tech war between the US and China, in which the US is aiming to constrain Chinas technological development and prevent it from exercising a global tech leadership role.

In 2020, the Trump administration imposed crushing sanctions on the Chinese tech giant Huawei that were designed to cut the company off from TSMC, on which it was reliant for the production of high-end semiconductors needed for its 5G infrastructure business.

Huawei was the worlds leading supplier of 5G network equipment but the US feared its Chinese origins posed a security risk (though this claim has been questioned). The sanctions are still in place because both Republicans and Democrats want to stop other countries from using Huaweis 5G equipment.

The British government had initially decided to use Huawei equipment in certain parts of the UKs 5G network. The Trump administrations sanctions forced London to reverse that decision.

A key US goal appears to be ending its dependency on supply chains in China or Taiwan for critical technologies, which includes advanced semiconductors needed for 5G systems, but may include other advanced tech in future.

Pelosis trip to Taiwan was about more than just Taiwans critical place in the tech war. But the dominance of its most important company has given the island a new and critical geopolitical importance that is likely to heighten existing tensions between the US and China over the status of the island. It has also intensified US efforts to reshore its semiconductor supply chain.

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Taiwan dominates the worlds supply of computer chips no wonder the US is worried - The Conversation Indonesia

The Blades manager only discovered on Thursday that his first signing of the summer, Bosnian centre-back Anel Ahmedhodzic, was carrying a suspension for bookings picked up on loan at Bordeaux from Malmo. It was compounded by an "innocuous" knee injury to fellow centre-back Jack Robinson the day before the game, days after Chris Basham had injured his hamstring at Shirecliffe.

On Ahmedhodzic's ban, Heckingbottom said: "Malmo should declare it but we want the player so what do we do? We asked the FA can we push it back, it's not our fault, we got lawyers involved. We asked, they wouldn't do it."

Joao Pedro's goal condemned the Blades to defeat at Vicarage Road, leaving Hull City as the only Yorkshire side to win in the second tier on the opening weekend as they beat Bristol City 2-1 on Saturday thanks to a late goal from Jean Michal Seri.

Elsewhere on Saturday, Rotherham United claimed a 1-1 draw at home to Swansea City while it was the same scoreline for Middlesbrough in their clash with West Brom at the Riverside Stadium.

On Friday, Huddersfield Town got the 2022-23 campaign underway with a home clash against Burnley as they lost 1-0 to Vincent Kompany's side at the John Smith's Stadium.

Following the first round of action, data experts at FiveThirtyEight have crunched the numbers to give every team's probability of winning the league, being promoted and being relegated.

With an explanation of how the model works HERE, here's where data experts are tipping every team to finish and how many points they will get in the Championship this season...

End of season probabilities - Relegation: 37%. Promotion: 1%. Championship title: <1%

Photo: Getty Images

End of season probabilities - Relegation: 30%. Promotion: 2%. Championship title: <1%

Photo: Getty Images

End of season probabilities - Relegation: 25%. Promotion: 3%. Championship title: <1%

Photo: Getty Images

End of season probabilities - Relegation: 21%. Promotion: 3%. Championship title: <1%

Photo: Getty Images

Read more here:

Supercomputer predicts where Sheffield United, Middlesbrough, Burnley, Watford, West Brom, Blackburn Rovers and others will finish in Championship...

Gelhardt, 20, who enjoyed an outstanding breakthrough season last term, has committed his future at Elland Road until the summer of 2027.

The former Wigan Athletic player featured 22 times for the first team in the 2021-22 campaign, scoring two goals at Premier League level.

United have also secured the futures of two other rising stars in the shape of forward Sam Greenwood and winger Crysencio Summerville, who have signed contracts until June 2026.

The trio's extended deals at Elland Road are a welcome boost ahead of the 2022-23 Premier League campaign, which gets underway when Arsenal take on Crystal Palace at Selhurst Park on Friday night.

Leeds are in action against Wolves on Saturday, after a summer of change at the club under Jesse Marsch. Kalvin Phillips and Raphinha have both departed but the Whites have reinvested the fees generated from those sales and spent close to 100m on new arrivals this window.

Ahead of the upcoming campaign, data experts at FiveThirtyEight have crunched the numbers to give every team's probability of winning the league, being promoted and being relegated.

With an explanation of how the model works HERE, here's where data experts are tipping every team to finish and how many points they will get in the Premier League next season...

End of season probabilities - Relegation: <1%. Top-four finish: 91%. Premier League title: 46%.

Photo: Getty Images

End of season probabilities - Relegation: <1%. Top-four finish: 83%. Premier League title: 30%.

Photo: Getty Images

End of season probabilities - Relegation: <1%. Top-four finish: 60%. Premier League title: 11%.

Photo: Getty Images

End of season probabilities - Relegation: <1%. Top-four finish: 42%. Premier League title: 5%.

Photo: Getty Images

Excerpt from:

Supercomputer predicts how Premier League relegation battle will unfold for Leeds United, Nottingham Forest, Everton, Newcastle United, Aston Villa...

Cast: Sydne MikelleTanner BuchananJason GenaoEmery KellyJade Chynoweth

Geners: FamilyScience FictionThriller

Director: Sean Olson

Release Date: May 29, 2020

Five teenagers compete to win a mansion owned by entrepreneur and scientist Atticus Virtue. To win the teens must face-off against a super computer named HAVEN who controls the mansion.

Unfortunately, Max Winslow and The House of Secrets is not on Netflix. But you can't go too wrong with what is still considered the most popular streaming service, though. For $9.99 per month Basic, $15.99 Standard, or $19.99 Premium, you can enjoy a huge volume of TV shows, documentaries, kids content, and more.

They're not on Hulu, either! But prices for this streaming service currently start at $6.99 per month, or $69.99 for the whole year. For the ad-free version, it's $12.99 per month, $64.99 per month for Hulu + Live TV, or $70.99 for the ad-free Hulu + Live TV.

Sorry, Max Winslow and The House of Secrets is not streaming on Disney Plus. With Disney+, you can have a wide range of shows from Marvel, Star Wars, Disney+, Pixar, ESPN, and National Geographic to choose from in the streaming platform for the price of $7.99 monthly or $79.99 annually

You won't find Max Winslow and The House of Secrets on HBO Max. But if you're still interested in the service, it's $14.99 per month, which gives you full access to the entire vault, and is also ad-free, or $9.99 per month with ads. However, the annual versions for both are cheaper, with the ad-free plan at $150 and the ad-supported plan at $100.

As of now, Max Winslow and The House of Secrets is not available to watch for free on Amazon Prime Video. You can still buy or rent other movies through their service.

Max Winslow and The House of Secrets is not available to watch on Peacock at the time of writing. Peacock offers a subscription costing $4.99 a month or $49.99 per year for a premium account. As their namesake, the streaming platform is free with content out in the open, however, limited.

Max Winslow and The House of Secrets is not on Paramount Plus. Paramount Plus has two subscription options: the basic version ad-supported Paramount+ Essential service costs $4.99 per month, and an ad-free premium plan for $9.99 per month.

No dice. Max Winslow and The House of Secrets isn't streaming on the Apple TV+ library at this time. You can watch plenty of other top-rated shows and movies like Mythic Quest, Tedd Lasso, and Wolfwalkers for a monthly cost of $4.99 from the Apple TV Plus library.

Nope. Max Winslow and The House of Secrets is not currently available to watch for free on Virgin TV Go. There are plenty of other shows and movies on the platform which may interest you!

Starz Play Amazon Channel

$8.99

Starz Roku Premium Channel

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Where to Watch and Stream Max Winslow and The House of Secrets Free Online - EpicStream

It went to plan for Northampton Town as they put last seasons pain behind them with a fine 3-2 win over Colchester United.

They head to newcomers Grimsby Town this weekend looking to make it two wins from two, with the supercomputer giving them a 47 per cent chance of doing the business.

Title favourites Salford City make the trip to Swindon in what should be a cracking fixture.

Relegation favourites Hartlepool United need a reaction against AFC Wimbledon, after being battered by Walsall last weekend.

Heres how supercomputer sees every League Two match going.

Get all the latest Cobblers news here.

Home win: 36%Draw: 29%Away win: 35%

Photo: Pete Norton

Home win: 64%Draw: 24%Away win: 12%

Photo: Pete Norton

Home win: 32%Draw: 27%Away win: 41%

Photo: JPCO Sport

Home win: 49%Draw: 25%Away win: 26%

Photo: Gareth Copley

Read more here:

Supercomputer predicts the likely result for Grimsby Town v Northampton Town, Gillingham v Rochdale, Hartlepool United v AFC Wimbledon and every other...

Mansfield and Tranmere will be looking to get up and running this weekend after suffering defeats in matchday one. It will be Stags who claim the points though, according to the supercomputer

Title favourites Salford City make the trip to Swindon in what should be a cracking fixture.

Promotion-chasing Northampton head to Grimsby Town, while relegation favourites Hartlepool United need a reaction against AFC Wimbledon, after being battered by Walsall last weekend.

Heres how supercomputer sees every League Two match going.

Get all the latest Stags news here.

Home win: 36%Draw: 29%Away win: 35%

Photo: Pete Norton

Home win: 64%Draw: 24%Away win: 12%

Photo: Pete Norton

Home win: 32%Draw: 27%Away win: 41%

Photo: JPCO Sport

Home win: 49%Draw: 25%Away win: 26%

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Supercomputer predicts the likely result for Mansfield Town v Tranmere Rovers, Colchester United v Carlisle United, Crewe Alexandra v Harrogate Town...

image:The new approach determines a users real-time reaction to an image or scene based on their eye movement, particularly saccades, the super-quick movements of the eye that jerk between points before fixating on an image or object. The researchers will demonstrate their new work titled, Image Features Influence Reaction Time: A Learned Probabilistic Perceptual Model for Saccade Latency, at SIGGRAPH 2022 held Aug. 8-11 in Vancouver, BC, Canada. view more

Credit: ACM SIGGRAPH

What motivates or drives the human eye to fixate on a target and how, then, is that visual image perceived? What is the lag time between our visual acuity and our reaction to the observation? In the burgeoning field of immersive virtual reality (VR) and augmented reality (AR), connecting those dots, in real time, between eye movement, visual targets, and decision-making is the driving force behind a new computational model developed by a team of computer scientists at New York University, Princeton University, and NVIDIA.

The new approach determines a users real-time reaction to an image or scene based on their eye movement, particularly saccades, the super-quick movements of the eye that jerk between points before fixating on an image or object. Saccades allow for frequent shifts of attention to better understand ones surroundings and to localize objects of interest. Understanding the mechanism and behavior of saccades is vital in understanding human performance in visual environments, representing an exciting area of research in computer graphics.

The researchers will demonstrate their new work titled, Image Features Influence Reaction Time: A Learned Probabilistic Perceptual Model for Saccade Latency, at SIGGRAPH 2022 held Aug. 8-11 in Vancouver, BC, Canada. The annual conference, which will be in-person and virtual this year, spotlights the worlds leading professionals, academics, and creative minds at the forefront of computer graphics and interactive techniques.

There has recently been extensive research to measure the visual qualities perceived by humans, especially for VR/AR displays, says the papers senior author Qi Sun, PhD, assistant professor of computer science and engineering at New York University Tandon School of Engineering.

But we have yet to explore how the displayed content can influence our behaviors, even noticeably, and how we could possibly use those displays to push the boundaries of our performance that are otherwise not possible.

Inspired by how the human brain transmits data and makes decisions, the researchers implement a neurologically-inspired probabilistic model that mimics the accumulation of cognitive confidence that leads to a human decision and action. They conducted a psychophysical experiment with parameterized stimuli to observe and measure the correlation between image characteristics, and the time it takes to process them in order to trigger a saccade, and whether/how the correlation differs from that of visual acuity.

They validate the model, using data from more than 10,000 trials of user experiments using an eye-tracked VR display, to understand and formulate the correlation between the visual content and the speed of decision-making based on reaction to the image. The results show that the new model prediction accurately represents real-world human behavior.

The proposed model may serve as a metric for predicting and altering eye-image response time of users in interactive computer graphics applications, and may also help to improve design of VR experiences and player performances in esports. In other sectors such as healthcare and auto, the new model could help estimate a physicians or a drivers ability to rapidly respond and react to emergencies. In esports, it can be applied to measure the competition fairness between players or to better understand how to maximize ones performance where reaction times come down to milliseconds.

In future work, the team plans to explore the potential of cross-modal effects such as visual-audio cues that jointly affect our cognition in scenarios such as driving. They are also interested in expanding the work to better understand and represent the accuracy of human actions influenced by visual content.

The papers authors, Budmonde Duinkharjav (NYU); Praneeth Chakravarthula (Princeton); Rachel Brown (NVIDIA); Anjul Patney (NVIDIA); and Qi Sun (NYU), are set to demonstrate their new method Aug. 11 at SIGGRAPH as part of the program, Roundtable Session: Perception. The paper can be found here.

About ACM SIGGRAPHACM SIGGRAPH is an international community of researchers, artists, developers, filmmakers, scientists and business professionals with a shared interest in computer graphics and interactive techniques. A special interest group of the Association for Computing Machinery (ACM), the worlds first and largest computing society, our mission is to nurture, champion and connect like-minded researchers and practitioners to catalyze innovation in computer graphics and interactive techniques.

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.

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The power of visual influence - EurekAlert

Lifelong fan David Clowes is now in charge and senior operators recruited in the likes of David McGoldrick, James Chester, Tom Barkhuisen, Conor Hourihane and James Collins give their promotion pitch an immediate element of seriousness and respect.

Whether Derby, in their first season at this level since 1985-86, return to the Championship will probably have as much to do with the impact of two talented young midfielders in Jason Knight and Max Bird and whether they keep them.

Another relegated side in Peterborough will also be conscious of keeping the family silver, with teenage defender Ronnie Edwards being courted by Manchester City. Sammie Szmodics, Harrison Burrows and Jack Taylor have also been linked with moves to higher-division clubs.

Further forward, Posh have a natural scorer at this level in ex-Rotherham player Jonson Clarke-Harris. If he fires and key players are retained, they should have a strong season led by a successful manager at this level in ex-Hull and Doncaster boss Grant McCann.

After the sale of Harry Darling and Scott Twine, MK Dons will do well to emulate their play-off feats of 21-22. At the other end of Buckinghamshire, Wycombes hopes will probably depend on getting another good year from elder statesmen Sam Vokes and Garath McCleary.

Ipswich, who have signed ex-Leeds defender Leif Davis for a significant fee for a League One club and former Millers forward Freddie Ladapo, should be firmly in the picture. The signing of Marcus Harness, for around 600,000, is a further indicator of their ambition.

The ambitions of the above clubs means that Sheffield Wednesday and Barnsley will have their work cut out this season as they seek promotion.

Ahead of the opening weekend's third-tier action data experts at FiveThirtyEight have crunched the numbers to give the probable outcome of every match...

Kick-off: 3pm, Saturday. Supercomputer prediction: Home win - 62%. Away win - 18%. Draw - 20%.

Photo: Getty Images

Kick-off: 3pm, Saturday. Supercomputer prediction: Home win - 41%. Away win - 33%. Draw - 26%.

Photo: Getty Images

Kick-off: 3pm, Saturday. Supercomputer prediction: Home win - 56%. Away win - 19%. Draw - 24%.

Photo: Getty Images

Kick-off: 3pm, Saturday. Supercomputer prediction: Home win - 35%. Away win - 41%. Draw - 24%.

Photo: Getty Images

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Supercomputer predicts every League One result this weekend with Sheffield Wednesday, Barnsley, Derby County, Ipswich Town, Lincoln City and Wycombe...

Heres a look at how HPC, AI, and other technologies are being used throughout the world by organizations to enhance healthcare research, drug development, public health, and patient outcomes.

The ability to gather, process, and analyze data from genomics, bioinformatics, microscopy, medical imaging, and other areas in the life sciences has been supercharged with HPC systems and artificial intelligence (AI) algorithms. Researchers can sequence vast quantities of DNA data faster than ever before with supercomputer resources and use AI to identify patterns and make predictions. They can now use these available and affordable technologies to study genes and proteins, to predict health events, automate imaging analysis, and generate ideas for improving healthcare delivery. Heres a look at how HPC, AI, and other technologies are being used throughout the world by organizations to enhance healthcare research, drug development, public health, and patient outcomes.

The COVID-19 pandemic has provided a test case for the ability of HPC to accelerate genomic sequencing as scientists around the world seek to track, understand, and combat the SARS-CoV-2 virus. In England, researchers at the Wellcome Sanger Institute have tracked the spread and mutations of the virus by sequencing over 300,000 coronavirus genomes. The institutes HPC cluster has 38,000 cores of compute, 23.5 petabytes of file systems, and a 30-petabyte virtualized storage repository, all supported by a 60 Gbps network backbone. Its complemented with an OpenStack private cloud with more compute and storage resources.

With HPC architectures and the use of machine learning and AI constantly evolving, the institute has worked with companies like Dell Technologies to build their HPC environment. Genomic sequencing data is stored for computational analysis on Dell PowerScale scale-out storage. Researchers use the data to determine the relatedness of different viruses and help identify chains of transmission, super-spreader events, and fast-growing variants.

A similar collaboration for genomic research between the Texas Advanced Computing Center (TACC) at the University of Texas and Dell Technologies spawned the Lonestar6 supercomputer, which can perform almost three quadrillion mathematical operations per second. It is being used by faculty members from throughout the University of Texas system at other universities for COVID-19 drug discovery and genomic research.

In another pandemic-related role for HPC, the staff at the Ohio Supercomputer Center at Ohio State University designed the COVID-19 Analytics and Targeted Surveillance System (CATS) to help school administrators decide whether it was safe to bring students back to classrooms or if fully remote or hybrid learning should be used instead. Supported by a HPC system with Dell PowerEdge servers with Intel Xeon processors, CATS serves 21 school districts and 238,000 students and tracks data like school nurse visits, student and teacher absences, and other metrics to watch for outbreaks and inform decision making. Sixteen different dashboards are used daily by thousands of people to provide the rationale for decisions like closing or opening schools or specific buildings on campuses.

In yet another use of HPC for COVID-19 research, Swansea University in Wales has built an open platform for mathematical modeling of disease transmission. It provides comparisons of multiple models to help researchers determine demographic, socioeconomic, and clinical risk factors for COVID-19 infection, morbidity, and mortality, among other uses. Supercomputer resources at two hubs, built by Dell Technologies and Atos, contain more than 13,000 cores, tens of terabytes of memory, and hundreds of terabytes of high-performance storage, all interconnected by low-latency, high-bandwidth networking.

The Cineca Consortium is a national supercomputing facility in Italy that supports public and industry research institutions with HPC resources. Among Cinecas 4000 projects is the Human Brain Project, which, in conjunction with 90 European research institutes, aspires to be the worlds most detailed model of the brain. A dedicated supercomputer has been built for the project with HPC technology from Dell and Intel.

To-date, researchers participating in the Human Brain Project have used HPC to explore brain mechanisms behind cognition, learning, and plasticity. Their research has led to more than 1,400 journal articles, a new treatment for spinal cord injuries, a brain prosthesis for the blind, and better modeling and understanding of epilepsy and autism.

A collaboration among researchers at the Washington University School of Medicine, the Memorial Sloan-Kettering Cancer Center, and Temple University, the [emailprotected] distributed computing project uses HPC to simulate how proteins impact a variety of diseases. To visualize protein dynamics on a molecular level requires enormous computational power and the projects founders came up with an original HPC solution harnessing the unused processing power of PCs from volunteers around the world. Each volunteer downloads an application that runs small parts of much larger simulations for the project. On the backend servers, algorithms put the separate parts together to create composite simulations.

Today this distributed HPC network has the equivalent of 2.4 exaflops of computational power, making it the first exascale computer. Teams from Dell Technologies and VMware are part of the legions of volunteers and the [emailprotected] client software resides on a VMware vSphere appliance. In December 2020, [emailprotected] was awarded the HPCwire Readers Choice Award for Best Use of HPC in Response to Societal Plights for its simulations of SARS-CoV-2 proteins.

For more on Dell Technologies for healthcare, life sciences, and HPC, please visitDellTechnologies.com/healthcareandDellTechnologies.com/hpc.

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Tapping HPC and AI for Global Health and Wellness - HPCwire

Students from Washington State University and Swedens Linkping University will participate in a pioneering exchange and research program in engineering and scientific computing, emphasizing the computing-based design philosophy that is supporting the international development of Boeings and Saabs new T-7A Red Hawk training aircraft.

The aircraft is an all-new advanced pilot training system designed for the U.S. Air Force, which will train the next generation of pilots for decades to come. As Boeing and Swedens Saab have long-standing ties to WSU and LiU, respectively, they will also support this program, which provides students with an unparalleled opportunity to learn how challenging designs are advanced through international cooperation of multinational corporations.

WSU was awarded $300,000 by the National Science Foundation to support WSU students in Sweden. The WSU-LiU team also received matching funding from the European Erasmus+ program and the Swedish Foundation for International Cooperation in Research and Higher Education to support the LiU students at WSU.

One of the objectives of this program is to graduate profession-ready students who are internationally educated and ready for leadership in a globalized society, said Joseph Iannelli, a professor of mechanical engineering in WSUs School of Engineering and Applied Sciences, who is leading the program.

Jan Nordstrm, a distinguished professor of computational mathematics, and Andrew Winters, a WSU alumnus and assistant professor in computational mathematics will supervise the students research projects at LiU.

LiUs multi-disciplinary strategy with Boeing and SAAB projects will expand students preparation for international high-tech environments, said Nordstrm.

This project will also prepare students for employment opportunities with corporations that employ scientific computing and operate in the U.S. and Sweden. said Iannelli. Students will benefit from studying in Sweden and the U.S. while gaining familiarity with the cultures of both countries.

Boeing and Saab will enrich this program. They will advise on aerospace-related scientific computing projects and mentor students, who will be offered opportunities for company site visits and internships. Students will also learn how computing-based designs lower development costs, increase first-time quality of prototypes, and decrease time to bring complex systems, such as aircraft, to markets.

Boeing is proud to support the education of up-and-coming engineers through this unique exchange and research program, said Craig Bomben, Boeing vice president of flight operations and enterprise chief pilot. This partnership will prepare students for the engineering field and help them fulfill their career ambitions.

WSU and LiU have been developing their international partnership for several years, after Iannellis 2018 outreach to LiU. Thereafter, the two universities signed a memorandum of understanding and a reciprocal student exchange agreement.

A comprehensive internationally-ranked peer university, LiU emphasizes multidisciplinary research and manages Swedens National Supercomputer Centre (NSC). By pooling their teams and financial resources, WSU and LiU can advance education and research at the international level more effectively, Iannelli said.

The three-year project will involve 42 diverse students; 21 from WSU and 21 from LiU. Each of the participating WSU students will receive a $12,000 fellowship.The project synergistically integrates two study-abroad semesters with a research experience and matched student cohorts. At LiU, the WSU students will be collaborating with an equal number of LiU students who will then complete an exchange semester at WSU. At LiU the Swedish students will assist the WSU students with the local culture and vice versa at WSU.

In Sweden, the WSU and LiU students willlearn how physical systems function through computer-based simulations that rely on mathematical algorithms. The WSU students will also take English-taught courses at LiU and transfer their academic credits towards their WSU degree requirements. The program is expected to begin in January.

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National Science Foundation and European Awards support students in Sweden and the U.S. WSU Insider - WSU News

Last seasons beaten play-off finalists Mansfield Town managed by a shrewd operator in the shape of ex-Sheffield United chief Nigel Clough lock horns with Salford City.

The Stags recruitment has been pretty quiet in truth, but they have retained last seasons cast who have considerable experience at lower-division level in the likes of Stephen McLaughlin, Jordan Bowery, Ollie Hawkins, John-Joe OToole and George Lapsie, George Maris and Rhys Oates.

Elliot Watt rejected fresh terms at Bradford to join Salford, who have also signed ex-Barnsley duo Stevie Mallan and Elliot Simoes and striker Callum Hendry, who hit 12 goals for St Johnstone in 21-22.

Not too far away from Salford, Stockport County back in the EFL after an 11-year absence have major momentum and their arrivals have also caught the eye. They have brought in former Northampton Town defender Fraser Horsfall, with the Huddersfield-born player and PFA League Two Team of the Year inclusion rejecting higher-level interest to join.

Kyle Wootton, who netted 22 times in all competitions for Notts County last term has also joined and another of the leading National League players of last season has signed in Torquay midfielder Connor Lemonheigh-Evans, whose goals total extended into double figures last term.

Crawley Town, backed by American-based crypto consortium WAGMI United LLC, could be ones to watch. They have brought in Newport County striker Dom Telford, who fired 26 goals for the Exiles last term.

Ahead of the opening weekend's fourth-tier action data experts at FiveThirtyEight have crunched the numbers to give the probable outcome of every match...

Kick-off: 3pm, Saturday. Supercomputer prediction: Home win - 52%. Away win - 22%. Draw - 26%.

Photo: Getty Images

Kick-off: 3pm, Saturday. Supercomputer prediction: Home win - 43%. Away win - 28%. Draw - 29%.

Photo: Getty Images

Kick-off: 3pm, Saturday. Supercomputer prediction: Home win - 26%. Away win - 51%. Draw - 23%.

Photo: Getty Images

Kick-off: 3pm, Saturday. Supercomputer prediction: Home win - 53%. Away win - 22%. Draw - 26%.

Photo: Getty Images

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Supercomputer predicts every League Two result this weekend with Bradford City, Doncaster Rovers, Swindon Town, Mansfield Town, Tranmere Rovers and...

The Robins failed to pick up points after defeat to Hull City at the weekend and face Sunderland at home in their next EFL Championship fixture.

Bristol City kicked off their 2022/23 EFL Championship campaign with a 2-1 defeat to Hull City at the MKM Stadium on Saturday.

The Robins are tipped for another difficult season in English footballs second tier and defeat on the opening day of the season came despite Andreas Weimanns 30th minute opener giving them the lead against the Tigers.

The result has done little to see them climb up the predicted final table of the FiveThirtyEight supercomputer - which uses Forecasts and Soccer Power Index (SPI) ratings to show each teams percentage chance of winning the title, reaching the play-offs and being relegated.

The statistics also provide a predicted points tally that each team will finish on when the regular season wraps up in May 2023.

The supercomputer predicts that Nigel Pearsons side will end the season on 56 points but what would that mean for their league position and what are their chances of out performing their current prediction?

Here is how the supercomputer predicts the 2022/23 EFL Championship table will look at the end of the season as of Monday, August 1 - after the weekends opening fixtures but before Watford take on Sheffield United in the Monday night game:

Win Championship: 23%, Promoted: 47%, Play-offs: 34%, Relegated: <1%

Win Championship: 19%, Promoted: 44%, Play-offs: 34%, Relegated: <1%

Win Championship: 13%, Promoted: 34%, Play-offs: 34%, Relegated: 1%

Win Championship: 12%, Promoted: 33%, Play-offs: 34%, Relegated: 1%

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Bristol Citys predicted finish in worrying verdict as Cardiff City, QPR and others also rated - BristolWorld