Resveratrol is a polyphenol present in and commonly ingested through grapes, red wine, berries, and peanuts.1 It is also a constituent of some Chinese and Japanese traditional medicines. Resveratrol is reported to have many health-promoting effects, with its potential anti-aging properties initiating its notoriety in the lay press. It is also reported to have anti-inflammatory, anti-oxidative, and anticancer effects. These studies have primarily been conducted in vitro and in animal models.

Though mechanisms of anticancer effects of resveratrol have been identified, the ability to translate these findings to in-human studies is a challenge.2 Resveratrol has low bioavailability in humans. Though it is easily absorbed in the small intestine, it undergoes extensive metabolism resulting in a low plasma concentration of trans-resveratrol.

As a result, various routes of administration have been tested in animal models, including via intravenous and oral transmucosal routes, which increase plasma levels. A micronized form has been developed for human studies, which increases the surface area and solubility of resevatrol and increases plasma concentrations by approximately 3.6-fold compared with non-micronized resveratrol.

Preclinical Studies

Numerous in vitro studies across different cancer cell lines have demonstrated that application of resveratrol results in cell growth inhibition and increased apoptosis.1,3 Several mechanisms have been attributed to these properties. Resveratrol has been demonstrated to modulate cyclin-dependent kinases resulting in cell cycle arrest, particularly at the G0/G1 checkpoint, although some studies have also shown cell cycle arrest at the G2/M and S checkpoints.

Apoptosis appears to be induced primarily through increased caspase activity, though noncaspase-dependent mechanisms have also been reported. Resveratrol has also been shown to inhibit some signaling pathways that frequently aberrant in different cancers, such as EGFR, mTOR/AKT, JAK/STAT, and PI3-kinase. Resveratrol has also demonstrated antioxidant properties and may protect DNA from oxidative damage.4

The mechanisms of the effect of resveratrol on breast cancer cells is less clear.5 Though studies have shown that the anticancer properties of resveratrol extend to breast cancer cells and animal models, it has also been shown to activate the estrogen receptor and, at higher concentrations, may upregulate the expression of HER2, both in the absence of estradiol.

Studies in rodent models have demonstrated that the topical application of resveratrol decreased the incidence of skin tumors and suppressed melanoma growth, with markers indicating increased apoptosis.1 In other cancer models, oral ingestion through diet, water, or oral gavage resulted in decreased tumor volume, weight, and growth with decreased metastasis and angiogenesis across multiple cancer types including those of the breast, prostate, lung, and colon. Similar results were found in animal models of liver cancer, though most studies used abdominal injection for resveratrol administration.

More:
Resveratrol and Cancer - Cancer Therapy Advisor

A good glass of red wine is one of lifes great pleasures. Its also one of the healthier alcoholic beverages to choose. Red wine has less natural sugar than white, and it boasts more iron, potassium, and carotenoids (good for eye health) too. While studies are mixed on resveratrol, a buzzy antioxidant found in red wine, its possible that these polyphenols may help prevent damage to blood vessels and protect against cholesterol buildup. Obviously, you shouldnt drink wine to get your daily nutrients or think of it as your main defense against heart damage. And we know we sound like a broken record, but the benefits of red wine are only beneficial when you drink in moderation! One standard (5 oz. of wine at 12% alcohol content) drink for women and two for men is generally considered to be safe. More than that, and youre doing more harm than good. But if youre down to drink responsibly and are looking for a few recommendations, these are our favorite American-made red wines to enjoy in 2020:

1Melville 2017 Estate Pinot Noir

$38.00

Pinot Noirs have the highest levels of resveratrol, and Melvilles Pinot Noir is about as close to perfect as you can getand reasonably priced at $38. Made at its Rita Hills estate and aged in French oak barrels, it features a complex, fruit-forward aromatic blend of pomegranate, rhubarb, tangerine zest, and cherries. Its balanced, fresh, and vibrant.

2Cuvaison 2017 Estate Pinot Noir

$42.00

This wouldnt be a wine list without a selection from Napa Valley, and from there we have to go with Cuvaison, a family-owned winery founded in 1969. Its Estate Pinot Noir is a little pricier than our Melville pick, at $42 a bottle, but for a special occasion its worth it. Youll find the aromas of rose petals, strawberries, and plumsand dark fruits on the palatehard to resist.

3Scribe 2018 Carneros Pinot Noir

$42.00

While Napa is the most famous part of California wine country, I secretly prefer Sonoma (at least to visit!). My favorite wine there is Scribe, founded by two brothers in 2007. This 2018 Pinot Noir blend came with its return to normal after the 2017 North Bay fires and the years of drought that preceded them. Here, youll get spice from Martini grapes rounded out by the earthiness in Pommard grapes.

4La Crema 2018 Monterey Pinot Noir

$18.40

Big Little Lies fans will love La Crema, a winery partially based in Monterey, where the popular show is filmed. Its 2018 Pinot Noir is reasonably priced at $28 and features flavors of plums, cranberries, and raspberries. The winemakers highlight its distinct minerality and notes of barrel spice.

52017 Justin Right Angle

$35.00

Another wine-making area I love in California is Paso Robles, and there my favorite is Justin. A good go-to is the 2017 Right Angle, a unique, full-bodied blend of cabernet, petite verdot, petit sirah, and malbec. Youll taste ripe black fruit, vanilla, and oak upon your first sip. Its affordable too, at $28 a bottle if you're a wine society member (and it's free to sign up).

6Cooper Mountain 2017 Pinot Noir

$28.00

Now were moving north, to the Willamette Valley in Oregon, where good wine often comes a little cheaper than in trendy California. One favorite is Cooper Mountain, which is organically grown and biodynamic. Its signature (and most affordable, at $28 a bottle) Pinot Noir is sourced from its three oldest estate vineyards and bursts with forest floor fruitblackberries, raspberries, and blueberries.

7Willamette Valley Vineyards 2018 Whole Cluster Pinot Noir

$20.99

Even more economical at around $24 a bottle, Willamette Valley Vineyardss Whole Cluster Pinot Noir is certified sustainable and incredibly versatile. The winemakers call it liquid fruit salad in a glass because it opens with aromas of ripe black cherry, strawberry, black currant, and raspberry. Itll go perfectly with any BBQ dish this summer.

8Montinore 2017 Red Cap Pinot Noir

$24.00

Montinore Estate is the largest producer of certified estate wines made from biodynamic grapes in the country (and its family-runKristin Marchesi manages the estate with her father!). Pinot Noirs are their specialty, and the 2017 Red Cap comes in at a great price point, just $24 a bottle. It's medium-bodied and has cherries, plum, and "a kiss of chocolate"on the palate.

9Bryn Mawr 2015 Tempranillo

$50.00

Yes, finally! A red that isnt Pinot Noir! I love Bryn Mawr vineyards in Salem, OR, because the winemaker and vineyard director is a woman, Rachel Rose. One of her speciality wines, the 2015 Tempranillo, is outstanding. Youll have to pay for it, at $50 a bottle, but thats because this blend ages in barrels for at least two years and then bottles for at least one prior to release, which allows the tannins to soften and flavors to concentrate.

10Left Coast White Pinot Noir

Now heres something coola blend that combines the beauty of a Pinot Noir with the brightness and acidity of a white wine. This started out as an experiment at Left Coast and is now one of its most popular varietals. Pure Pinot Noir juice is fermented in stainless steel, then aged on the lees. Youll taste honeysuckle, pear, peach, and pineapple with a smooth, refreshing finish.

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10 Best Red Wines of 2020 - Best Red Wine for Health - Prevention.com

Last week we discussed some myths related to breast cancer as debunked by Dr Kristi Funk, in her book Breasts, the owners manual. This week we will discuss the subject of foods that are helpful in preventing breast cancer. Diet is only one of many factors related to breast cancer development, but happens to be the most important. It is thus useful to spend some time on this subject.

ALSO READ : Turning the Tide: Breast cancer Facts and fallacies (Part 2)

Our amazing bodies are designed to maintain homeostasis living in harmony with destructive and constructive forces. Each cell is a highly complex megacity of functions working together to maintain function reproduction, elimination of waste and physiological and structural integrity. All the information to perform all these functions is encoded in the rather fragile DNA (De-oxyribonucleic acid) strands which are the source of the approximately 25,000 genes that provide guidance to all living functions. Our diet is the source of hundreds of thousands of phytochemicals which provide profound anti-cancer and anti-inflammatory properties that target destructive forces seeking to disrupt these delicate processes. Many factors promote the development of cancers like cigarette smoke, carcinogens in our diet and in our environment, inefficient immune systems, lack of exercise and chronic stress, to name a few. It makes sense to learn how we can boost the protective factors in the battle against cancer. Most of these are found in our diet. This information relates not just to breast cancer but to all cancers.

Have you ever heard about phytochemicals before? I have mentioned these on a number of occasions on these blogs. Here are some of the well-known ones that have been shown to have anti-cancer effects and their main sources:

sulforaphane (broccoli, kale)

indole-3-carbinol (broccoli, kale)

genistein (soy)

diallyl sulphide (garlic)

ellagic acid (berries, walnuts)

curcumin (turmeric)

epigallocatechin gallate (green tea)

resveratrol (red grapes)

omega-3 fatty acids (flaxseeds, chia seeds, avocado)

procyanidins (berries)

lycopene (tomatoes, watermelon)

anthocyanidins (apples)

limonene (oranges)

carotenoids (orange fruits and vegetables)

How do these phytochemicals work?

This is certainly a mighty powerful list of activities by these tiny chemicals found so abundantly in plant-based foods. Unfortunately modern processing methods end up denuding many of our foods of these vital substances. Food manufacturers then try to impress us by listing the smattering of minerals and vitamins with which they have enriched our foods.

Far too many people have never learned to appreciate the flavours and textures of plant foods.

It behooves especially moms, but also dads to instil in the palates of young children the love for fruits and vegetables and other plant foods. As Kristi Funk says so succinctly If you really want to defeat cancer, then eat like you mean it.

How do we obtain all these amazing phytochemicals? Certainly you dont find them on the shelves of pharmacies in little bottles of supplements well you might find a few there. But they are best obtained in their natural sources a wide variety of colourful fruits and vegetables green, yellow, orange, red, purple and white; in whole grains like oats, and brown or black and wild rice, wheat, barley, quinoa, maize; legumes like soy, beans, chick-peas, lentils; finally, nuts like almonds, walnuts, and seeds like chia and linseeds, etc. Most of these are accompanied by another health-promoting ingredient fibre. This is one essential nutrient absent in animal products.

What can you do to ensure that you are obtaining all you need of these vital substances each day? Kristi advises that you should consume 10 servings (about 5 cups) of fruits and vegetables daily. It is helpful to include 2 servings of each of the colours per day green, red, yellow, orange, brown/white. That 10 servings is not including all the whole grains and legumes. By the way if you are eating this plant-strong diet, you can eat an enormous amount of food each day without gaining weight in fact you will be surprised that you are actually losing weight without even really trying.

Kristi Funk spends a lot of time sharing her research on soy and breast cancer. She herself at one time discouraged the use of soy in relation to breast cancer, because of its known oestrogenic properties. However it turns out that soy actually blocks the development of breast cancer, especially if consumed during childhood and youth. Soy does not increase breast cancer but in fact decreases the occurrence, recurrence, and death rates in every single study exploring this matter since 2009. Good sources of soy proteins include tofu, soybeans (edamame), roasted soybeans and soy milk both long-life and powdered milk.

There is so much more information in Kristi Funks book, which I recommend to your reading.

Next week we will present a synopsis of her chapter on foods to avoid for healthy breasts, and to avoid breast cancer.

The best way to benefit from all this helpful information is to sit down and contemplate practically what you can do to incorporate this into your daily lifestyle. How will this information affect what you eat for breakfast, lunch and supper/dinner. How will it affect your grocery shopping behaviour? Might it be helpful to have a serious conversation with your family and discuss changes you can begin to transform your diet from one that is poor in nutritional value, to one that is bursting with a cornucopia (now there is a fancy word you can look up on your smartphone) of vital nutrients. This is a journey well worth beginning.

PS much of the information in this blog is mined out of Kristi Funks book. However I have added information from other sources where appropriate. I highly recommend you obtain her book for far more in-depth discussion about the subject.

Have a great week.

Dave Glass

Dr David Glass MBChB, FCOG (SA)

Dr David Glass graduated from UCT in 1975. He spent the next 12 years working at a mission hospital in Lesotho, where much of his work involved health education and interventions to improve health, aside from the normal busy clinical work of an under-resourced mission hospital.

He returned to UCT in 1990 to specialise in obstetrics/gynaecology and then moved to the South Coast where he had the privilege of, amongst other things, ushering 7000 babies into the world. He no longer delivers babies but is still very clinically active in gynaecology.

An old passion, preventive health care, has now replaced the obstetrics side of his work. He is eager to share insights he has gathered over the years on how to prevent and reverse so many of the modern scourges of lifestyle obesity, diabetes, ischaemic heart disease, high blood pressure, arthritis, common cancers, etc.

He is a family man, with a supportive wife, and two grown children, and four beautiful grandchildren. His hobbies include walking, cycling, vegetable gardening, bird-watching, travelling and writing. He is active in community health outreach and deeply involved in church activities. He enjoys teaching and sharing information.

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Turning the Tide Lifestyle Medicine and Breast Cancer (Part 3) - South Coast Herald

A quick list of what foods are high in Resveratrol

Grape skins and seeds, juice, especially red grapes. Red wine. Blueberries. Raspberries, Mulberries, and Cranberries all have high concentrations of resveratrol Strawberries, contained mainly in the seeds Nuts and peanuts Resveratrol has been identified in trees, and in a few flowering plants The most concentrated source of resveratrol is Japanese knotweed

Resveratrol is found mostly in the skins of grapes and dark colored berries. Blueberries are amongst the highest concentration. Purple and Red berries as well as wine made from them have very high amounts of resveratrol.These plants produce resveratrol as a defense against their environments. It is this substance that is helpful to humans.The most concentrated source of resveratrol is Japanese knotweed. Most resveratrol supplements are made from this source.Strawberries also contain resveratrol. Interestingly, the resveratrol is concentrated primarily in the seeds.A good source of resveratrol is peanuts. In berries, most of the resveratrol is found in the skins, however, the whole peanut contains the ingredient. There is even more resveratrol when peanuts are boiled as opposed to eating them raw. (When would you boil peanuts?)

Annual sales of resveratrol supplements in the U.S. continue to rise, while few studies have evaluated the benefits of resveratrol in humans. Popularity may be entirely due to studies on animals and cells in labware.

Weve all hear about how you would need to drink a million glasses of red wine a day or eat 17 pounds of grapes to get what is found in a single resveratrol supplement capsule.

But the truth of the matter is, your body doesnt really dig oral supplements; it works very hard trying to destroy them. In contrast, your body loves grapes!However, the oral bioavailability of resveratrol is almost zero.

It has been suggested that high doses of resveratrol is the only way to go if you want all the super human health benefits. Doses of up to five thousand milligrams a day appear to be safe, however, long-term effects in humans have not been studied.

Taking resveratrol with Quercitin and or Lecithin have been suggested to improve absorption.

Until we get a handle on this resveratrol trend, I recommend simply eating lots of fruits and vegetables daily.

Btw, whens the last time you heard anyone say, I just took some resveratrol today, and boy do I feel fantastic!

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What Foods Are High in Resveratrol? Longevity Unlocked

Long life expectancy can be achieved through some simple lifestyle changes. Alongside eating a healthy diet, regular exercise, plenty of sleep, moderate alcohol intake and not smoking are also important.

When it comes to what foods and drinks to consume to live longer, the ingredient in mulled wine have been shown to hold a host of benefits.

Mulled wine is made from red wine mixed with various spices, including cinnamon, ginger, cloves and nutmeg.

While it should be consumed within alcohol guidelines - no more than 14 units a week - here are the benefits of enjoying the festive tipple this Christmas.

Small mounts of red wine have been linked to more health benefits than any other alcoholic drink, and relationships between wine-drinking and lower risk of heart disease have been drawn.

READ MORE:Type 2 diabetes: Foods that could increase your risk of developing the condition

Drinking small amounts of red wine may reduce the risk of heart disease by helping to retain good HDL cholesterol in the blood.

Oxidative damage and the oxidation of the bad LDL cholesterol may be reduced by up to 50 percent.

Some studies have even suggested populations already at a high risk of heart disease, like the elderly, may benefits even more from moderate wine consumption.

Many studies have shown moderate wine drinkers are at lower risk of death from heart disease compared to non-drinkers or beer and spirit drinkers.

Red wines powerful plant compounds and antioxidants, such as resveratrol, have also been proven beneficial.

Resveratrol is found in grape skin and is produced in some plants as a response to damage or injury.

The antioxidant has been linked with fighting inflammation and blood clotting, as well as a reduced risk of heart disease and cancer.

Resveratrol has also been shown to make test animals live longer.

But it should be noted the resveratrol content of red wine is low, and you would have to consume several bottles per day to reach the amount used in animal studies.

Cinnamon has been shown to reduce the risk of heart disease by reducing cholesterol.

It reduced levels of total cholesterol, bad LDL cholesterol and triglycerides, while good HDL cholesterol remains stable.

A review study concluded a cinnamon dose of just 120mg per day can have these effects.

Ginger has also been shown to lower cholesterol levels.

In a 45-day study of 85 individuals with high cholesterol, 3g of ginger powder caused significant reductions in most cholesterol markers.

Research has shown the compounds found in cloves could help keep blood sugar under control.

If blood sugar remains high over a long period of time it can increase the risk of serious health problems, including cardiovascular disease.

An animal study found clove extract helped moderate blood sugar increases in diabetic mice.

Animal studies have shown taking high-dose nutmeg supplements can reduce heart disease risk factors, such as high cholesterol and high triglycerides levels.

More human studies is needed, but other health benefits of nutmeg include anti-inflammatory properties and improved blood sugar control.

Original post:

How to live longer: The Christmas drink that could increase your life expectancy - Express

Everyone knows that wine, in moderation, is good for you. The medicinal benefits of drinking a glass of red wine in the evening have been well documented.

Back in the 1990s it became known as the French paradox after a groundbreaking study showed that the French whose diet is typically rich in cholesterol and saturated fats but also insist on a glass or two of wine with their meals suffer from 40% fewer coronary heart ailments than Americans.

Since then, wine has been widely recognized as a central factor in preventing cardiac events and atherosclerosis. Drinking wine can literally extend your life.

Now Israeli researchers are trying to produce the worlds first super wine that condenses all the beneficial factors of fermented grapes without affecting the wines taste, tones or tannins.

Wine contains antioxidants and other substances that help our bodies defend against various ailments, but at a relatively low concentration, explains Meir Shlisel, a senior lecturer in food science at the Academic and Technology College of Tel Hai. Theres a limit to how much of it you can drink because of the amount of alcohol.

For three years, researchers at Tel Hai College have been working on an innovative recipe to make a single glass of wine many times healthier effectively turning it into a superfood that confers exceptional health benefits due to its nutrient density.

Stressed grapes

We take the grapes and expose them to stress, Shlisel explains to ISRAEL21c.

This is a form of organic stress, not genetic modification or anything like that. Its a bit like how parents pressurize their kids into academic achievements. The grapes naturally begin to produce substances that are healthy for us, only now these substances are at concentrations many times greater.

Specifically, he is trying to raise the naturally occurring levels of resveratrol, part of a group of compounds called polyphenols found in the skin of red grapes that act likeantioxidants, protecting the body against damage that can put you at a higher risk of contracting cancer and heart disease.

Resveratrol is a stilbenoid, the family of molecules with the most beneficial properties among the rich diversity of components in red wine.

The research is based on the idea that exposing wine grapes to the oxidative stress of ozone will cause an increase in the level of stilbenes in general and resveratrol in particular in these grapes.

Shlisels team used the last grapes to be picked in the season, which in the Golan Heights can be in late September.

Exposing the grapes to ozone gas immediately after harvest in an atomized chamber yielded encouraging results: an increase of up to six times the level of resveratrol compared to grapes not treated with ozone after harvest.

The next stage in the research will involve preparing wine from grapes with high levels of resveratrol and stilbenoids and testing its organoleptic properties.

The ultimate goal is to invent and develop a system that will enable the production of healthy wine, to be marketed as a superfood in Israel and around the world.

Pluck the leaves

Meanwhile, at the nearby MIGAL Galilee Research Institute, a local independent agricultural research organization, researchers have made a fascinating discovery.

We discovered that if we remove vine leaves at a very early stage this exposes the grapes to more sunlight and they develop a defense mechanism against radiation, which comes in the form of antioxidants, explains Omer Crane, who researches the physiology of grapevine and deciduous fruit trees at the MIGAL Institute.

Wine produced from these grapes maintains this high level of antioxidants, Crane tells ISRAEL21c.

Our research is aimed at making the actual grapes smaller, with thicker peel. Most of the taste and qualities of wine derive from the grapes peel, not the inside, he points out.

Another unexpected effect is that the vines are more resistant to fungi and other pests. The result is wine with more health benefits from vines that need less spraying. Ultimately, it will save work.

Crane and Shlisel say their approaches to producing more health-beneficial wine can complement each other.

These are two separate studies with different aims, but the approaches can certainly be combined, says Crane.

Israels robust wine industry

Israel has at least 300 wineries producing over 42 million bottles of wine annually.

Exports leapt in 2018 to $47 million, and the industrys turnover has crossed the billion-shekel mark. Israeli wines can be easily found across Spain, Italy and the United States.

At the same time, Israel is becoming a leading innovator in the food-tech field. Much of this development is aimed at the superfood market, estimated to be worth $18 billion annually.

This year, the two wine researchers entered an acceleration program run by the Economics Ministrys Small Business Agency, with the aim of establishing the worlds first super-wine startup.

The idea is not to sell wine, but the technology, says Shlisel. Im an academic my primary motivation was curiosity and I didnt think about a startup when I began this research. The process can be performed anywhere in the world and adjusted to local conditions.

Shlisel is waiting with bated palate to taste the results of this years crop of merlot, shiraz and cabernet sauvignon.

Wine takes several months before it is ready. Until now, friends who claim to understand wine say they cant tell the difference.

Read the original post:

Israelis plan to produce the world's first 'super wine' - ISRAEL21c

Every week there are numerous scientific studies published. Heres a look at some of the more interesting ones.

Some Antibiotics Prescribed During Pregnancy Linked to Birth Defects

Researchers at the University College Londonfound that children of mothers prescribed macrolide antibiotics in the first trimester of pregnancy were at increased risk of major birth defects. The research was published in The BMJ. The birth defects include major malformations such as heart and genital defects, and four neurodevelopment disorders, cerebral palsy, epilepsy, ADHD, and autism spectrum disorder.

Macrolide antibiotics are used to treat a wide variety of bacterial infections and are among the most frequently prescribed antibiotics during pregnancy in Western countries, said Heng Fan, PhD candidate at UCL Great Ormond Street Institute of Child Health, and lead author of the study. This work builds on previous evidence of rare but serious adverse outcomes of macrolide use, especially for unborn babies. These adverse outcomes were assumed to be associated with the arrhythmic effect of macrolides, and policy advice about their use in pregnancy varies.

The investigators analyzed data from 104,605 children born in the UK from 1990 to 2016 from the Clinical Practice Research Datalink (CPRD), with a median follow-up of 5.8 years after birth. An additional 82,314 children whose mothers were given macrolides or penicillins before pregnancy and 53,735 who were siblings of children in the study acted as control cohorts. Major malformations were seen in 186 children of 8,632 whose mothers received macrolides at any point during pregnancy and 1,666 of 95,973 children whose mothers were dosed with penicillins during pregnancy. The researchers concluded that macrolides during the first three months of pregnancy were associated with an increased risk of any major malformation compared to penicillin.

The Mediterranean Diets Key Ingredient for Extending Lifespan

The Mediterranean diet has been noted for being heart-healthy and potentially improving lifespanheavy on fish, fruits, vegetables, grains, olive oil and red wine. Much research suggested the resveratrol found in red wine was the major contributor, but new research suggests it is actually the fat found in olive oil that activated a pathway known to increase lifespan and prevent aging-related diseases. It appears that the fat gets stored in lipid droplets and when the fat is broken down during exercise or fasting, the signaling and health benefits occur.

What Facebook and Genomes Have in Common

Computational biologists at Carnegie Mellon Universitytook an algorithm used to study social networks like Facebook and adapted it to identify how DNA and Proteins behave in communities inside the cell nucleus. Proximity is a factor, because genes controlled by the same regulatory proteins benefit from being close to each other, but others can be relatively far apart but drawn together via shared interests. The MOCHI algorithm analyzes the spatial arrangement of all the genes and transcription factor proteins in a nucleus based on genome-wide chromosome interactions and global gene regulatory networks.

A 3D Atomic Scale Map of the 2019 Coronavirus

Investigators at the University of Texas at Austin and the NIH created the first 3D atomic scale map of the 2019 novel coronavirus. They used AMETEK Gatans K3 camera to map part of the virus called the spike protein, which is how the virus penetrates the host cells. The breakthrough should allow for more rapid vaccine and therapy development.

How Lung Cancer Cells Suck Up Energy

Researchers working with human lung cancer cells discoveredhow they modulate their energy consumption based on their surroundings. In addition, they discovered how cancer cells override those factors to maximize their energy use. They identified a protein called TRIM21 that appears able to prevent the degradation of metabolic enzymes, resulting in cancer cells keeping their metabolism high. Being able to interrupt this pathway could lead to new approaches to cancer therapies.

New Hope for Muscular Dystrophy

Although there are now a couple therapies on the market for Duchenne muscular dystrophy (DND), it is still incurable. Researchers at the University of Pennsylvania School of Medicinerecently identified a group of small molecules that might lead to new treatments. The compounds eased repression of a specific gene, utrophin, in mouse muscle cells. This allows the body to produce more utrophin protein, which can be substituted for dystrophin, the protein whose absence causes DMD.

Were trying to find therapies that will restore a patients muscle function without resorting to gene therapy, said Tejvir S. Khurana, the studys senior author and professor of Physiology. Increasing utrophin is a major focus of muscular dystrophy research. While, ideally, we would replace the missing dystrophin in patients, there are a number of technical and immunological problems associated with this approach.

One is simply that the dystrophin gene is the largest in the body, and cant be fit into the viruses used for gene therapy. Most approaches along those lines use truncated dystrophin genes or other means to introduce a partial dystrophin gene or gene product. The other problem is that because the human body of DMD patients doesnt have regular amounts or types of dystrophin, introducing dystrophin to the body often stimulates an immune response as the immune system reacts to it as an invader.

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Research Roundup: Antibiotics Linked to Birth Defects and More - PharmaLive

The global sales of resveratrol are likely to exceed 370 thousand units in 2019, as per a new FMI research study. The study finds that demand for resveratrol has significantly taken off over the past few years on the back of growing demand from three key verticals- cosmetics, pharmaceutical, and dietary supplement applications. Owing to their extraordinary capabilities in healing and managing cardio-vascular diseases, cancer, and neurological disorders, resveratrol is finding extensive applications in pharmaceuticals, notably specialty drugs. FMIs new research study onresveratrol marketenunciates on the evolving landscape, highlighting key insights to the fore.

According to the product, natural resveratrol remains the top-selling variant, with global sales poised to exceed 300 thousand units in 2019. With cosmetics industry witnessing the greatest measurable impact to date from rising consumer bias toward natural products, the status quo apropos of demand for natural resveratrol remains unaltered over the forecast timespan. As per the report, solid form of resveratrol continues to gain immense favor with global sales anticipated to surpass 280 thousand units in 2019, on the back of sweeping use across multiple application verticals.

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Consumer awareness with regard to resveratrols potential health benefits has significantly revved up, alongside favorable research studies demonstrating its numerous health benefits. According to the report, demand for resveratrol in dietary supplements is emerging a palpable trend picking in the food supplement landscape, with resveratrol moving out of the specialty diet space and mainstreaming in the functional food category, says FMI report.

As per the FMI report, the market growth continues benefit from approvals sanctioned by prominent organizations apropos of resveratrol-based food supplement launches. For instance, DSM Nutritional Products, a leading food and beverage producing company, received the European Union (EU) novel foods approval for resVida, which is a trans-resveratrol for use in food supplements, in either capsule or tablet form. Particulars as such provide substantial credence to the burgeoning adoption of resveratrol in food and dietary supplements over the forecast period.

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With potential antioxidant capabilities, personal care and cosmetic products containing resveratrol remain highly-favored by customers for attaining the desirable anti-aging effects. However, the shorter duration of resveratrols efficacy is denting consumer confidence, which is posing challenges vis--vis its adoption in skin care products.

Ambiguities over Health Benefits of Resveratrol Denting Consumer Confidence

While favorable studies vouch for the multimodal benefits of resveratrol, specific side-effects are likely to trigger a slowdown in the adoption rate. For instance, as per a recent revelation by National Institute of Health (NIH) in May 2018, resveratrol might cause potential effects, such as headache, nausea, fatigue, and so on. Furthermore, some research findings have also pinpointed that resveratrol can cause supplement-drug interactions with anticoagulants and estrogens, which is further expected to hinder the adoption rate of resveratrol.

Europe is likely to show strong growth over the forecast timeline, notably driven by strategic mergers and acquisitions by leading players to expand their product portfolio with resveratrol-based offerings. For instance, Evolva, a Swiss-based biotech company, launched Veri-teTM, an exclusive resveratrol ingredient, which bought a substantial hike in the companys overall sales revenue.

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Companies operating in the resveratrol market are witnessing longstanding issues in the supply chain framework. In line with the aforementioned, these companies are vying to deliver products that are cost-competitive and produced via sustainable methods, such as bio-production. Key brands are singing strategic distribution agreements and expanding in terms of geographical presence as well as product ranges to solidify their market sustenance.

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Resveratrol Market is Projected to Register at a Healthy CAGR of 8.1% During the Forecast Period 2018 2028 - Global Banking And Finance Review

Peanuts health benefits: Peanuts are heart-healthy, weight loss-friendly legumes that become deliciously crunchy in winter. Read here to know 8 reasons why peanuts must be a part of your diet.

Health benefits of peanuts: Peanuts are perfect to beat evening hunger pangs

Peanuts are heart-healthy legumes that can make for a perfect snack for winter. It is rich in protein and fats that can benefit you in many ways. While they are available throughout the year, in winters, though, they become deliciously crunchy and irresistible. Not just for your health, peanuts can help improving longevity, immunity and much more. In one of his posts on social media, lifestyle coach Luke Coutinho talks about the many benefits of including peanuts in your diet.

Before talking about peanuts, it is important to know that peanuts are best consumed when they are salt-free and roasted. Consuming salted peanuts that are sold commercially or come in nuts and trail mix that is sold in the market. Peanuts are best consumed fresh and roasted without any salt, stresses Luke in his video. This is because commercially available peanuts are made with added salts and preservatives that do more harm than good.

Have roasted salt-free peanuts for weight loss and good healthPhoto Credit: iStock

Also read:Peanut Butter For Weight Loss And Other Health Benefits You Cannot Miss

Peanuts are easily available and contain loads of good fats that benefit your heart, brain, skin and hormonal balance. Peanuts are rich in protein and antioxidants that offer protection from damage caused by free radicals in the body.

1. 100 gms of peanuts contain somewhere around 25.8 gm of protein, informs Luke. But you should have not more than half a handful or a handful peanuts at a time. This can aid weight loss as well. Protein is an important macronutrient that helps in building muscles. Eating protein can fill you up and keep you feel full for longer, thus reducing overall calorie intake and aiding weight loss.

2. Peanuts are great for your hair as they contain biotin. Biotin can help people suffering from hair fall and alopecia, deficiency of zinc, iron and B-vitamins. Adding peanuts to your diet can help meet these deficiencies and improve your hair quality.

Also read:Winter Hair Care: Hair Problems Giving You A Hard Time? Try These Remedies To Fight Different Winter Related Hair Problem

3. Peanut is rich in copper, manganese, folate and folic acid. This makes peanut a great addition in pregnancy diet.

4. Latest research on peanuts, says Luke, mentions that peanuts are rich in resveratrol. This nutrient is great for people with cancer. It can help those who are recovering from an illness and give a boost to immune system.

5. Peanuts can help in reducing inflammation, which is the root cause of most diseases. Type 2 diabetes, Alzheimer's disease, Parkinson's disease and even cancer are inflammatory conditions. Resveratrol in peanuts help in reducing inflammation.

6. Resveratol helps in keeping endothelial cells in blood vessels healthy, and this is what benefits heart health.

7. Peanuts are perfect to beat evening hunger pangs. Whenever you feel like snacking on something deep fried of essentially junk, grab a handful of peanuts and they will satisfy you almost instantly.

8. Peanut butter is also great, as far as you make it on your own, or buy ones which are not loaded with ingredients apart from peanuts. Peanut butter is formed with the help of oil released by peanuts. Avoid ultra processed and sugar-sweetened peanut butter.

Try to make peanut butter at home to reap maximum benefits from itPhoto Credit: iStock

All in all, including foods like peanuts in your diet can give a boost to your overall health.

Also read:Peanut Butter For Weight Loss And Other Health Benefits You Cannot Miss

Points to note

(Luke Coutinho, Holistic Lifestyle Coach - Integrative Medicine)

Disclaimer: This content including advice provides generic information only. It is in no way a substitute for qualified medical opinion. Always consult a specialist or your own doctor for more information. NDTV does not claim responsibility for this information.

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Resveratrol, Protein And Other Components In Peanuts That Make Them One Of The Healthiest Legumes In Existence - Doctor NDTV

Its not uncommon to look for ways to boost your sex drive.

Although some pharmaceutical drugs like Viagra may help, many people prefer natural alternatives that are readily available, discreet, and likely to have fewer side effects.

Interestingly, research has shown that several foods and supplements may help boost your libido and treat erectile dysfunction.

Here are 7 foods and supplements that may act like Viagra to boost your libido.

Tribulus terrestris is a small leafy plant whose roots and fruit are popular in traditional Chinese and Ayurvedic medicine (1).

Its also widely available as a sports supplement and commonly marketed to boost testosterone levels and improve sex drive.

While human studies havent shown that it can raise testosterone levels, it appears to increase sex drive in both men and women.

In a 90-day study in women reporting low sexual pleasure, taking 750 mg of Tribulus terrestris daily increased sexual satisfaction in 88% of participants (2).

Whats more, a 2-month study in men revealed that taking 7501,500 mg of Tribulus terrestris daily improved sexual desire in 79% of them (3).

However, studies in men with erectile dysfunction show mixed results.

One study found that taking 800 mg of this supplement daily for 30 days did not treat erectile dysfunction. Conversely, in another study, taking 1,500 mg daily for 90 days improved erections, as well as sexual desire (4, 5).

As such, more research is needed on Tribulus terrestris and erectile dysfunction.

Tribulus terrestris may help raise libido in men and women. Yet, results regarding its ability to treat erectile dysfunction are inconsistent, so more research is needed.

Maca (Lepidium meyenii) is a root vegetable traditionally used to enhance fertility and sex drive. You can buy supplements in various forms, including powders, capsules, and liquid extracts.

A 12-week study noted that 42% of men who took 1,5003,000 mg of maca daily experienced an increased sex drive (6).

Furthermore, in a review of 4 studies in 131 people, taking maca consistently for at least 6 weeks improved sexual desire. It also helped treat mild erectile dysfunction in men (7).

Additionally, some evidence suggests that maca may help combat the loss in libido that may occur as a side effect of certain antidepressant drugs (8).

Most studies found that taking 1.53.5 grams daily for at least 212 weeks was sufficient to boost libido (6, 7).

Maca may help boost libido and improve erectile function in men with mild erectile dysfunction.

Ginseng and red ginseng in particular may aid low libido and improve sexual function.

A 20-week study in 32 menopausal women found that taking 3 grams of red ginseng per day significantly improved sexual desire and function, compared with a placebo (9).

In addition, red ginseng may boost the production of nitric oxide, a compound that aids blood circulation and helps muscles in the penis relax. In fact, studies have revealed that this herb was at least twice as effective as a placebo at enhancing erectile function (10, 11, 12).

However, other studies have found no effect of red ginseng on libido or sexual function, and some experts question the strength of these studies (13, 14, 15).

Thus, more research is needed.

Red ginseng is generally well tolerated but may cause side effects, such as headaches and upset stomach. It may also interact with medications like blood thinners, so those who take them may want to consult a medical professional before use (10).

Red ginseng may boost libido and enhance erectile function, though more research is needed.

Fenugreek is a popular herb in alternative medicine that may help enhance libido and improve sexual function.

It contains compounds that your body may use to produce sex hormones, such as estrogen and testosterone (16, 17).

A 6-week study in 30 men found that supplementing with 600 mg of fenugreek extract daily increased strength and improved sexual function (18).

Similarly, an 8-week study in 80 women with low libido determined that taking 600 mg of fenugreek daily significantly improved sexual arousal and desire, compared with the placebo group (19).

That said, very few human studies have examined fenugreek and libido, so more research is needed.

In addition, this herb interacts with blood-thinning medications, such as warfarin. If youre on a blood thinner, you should speak with your medical practitioner before taking fenugreek (20).

Fenugreek may boost libido in both men and women by encouraging the production of sex hormones.

Saffron is a delicious spice derived from the Crocus sativus flower.

Its many traditional uses range from reducing stress to acting as an aphrodisiac, especially for people on antidepressants.

A 4-week study in 38 women with a low libido on antidepressants found that taking 30 mg of saffron daily significantly improved several sexual issues, such as decreased arousal and lubrication, compared to a placebo (21).

Similarly, in a 4-week study in 36 men who struggled with desire and arousal related to antidepressant use, taking 30 mg of saffron daily significantly improved erectile function, compared with taking a placebo (22).

Whats more, a review of 5 studies in 173 people noted that saffron significantly improved various aspects of sexual pleasure, desire, and arousal in men and women (23).

However, in people who dont have depression or are not taking antidepressants, results are mixed (24).

Saffron may boost libido in people on antidepressants, but its effects are inconsistent in those not taking these drugs.

Gingko biloba is a popular herbal supplement in traditional Chinese medicine.

It may treat various issues, including sexual disorders like erectile dysfunction and low libido, as it can raise blood levels of nitric oxide, which aids blood flow by promoting the expansion of blood vessels (25, 26).

That said, studies in humans reveal mixed results.

One 4-week study in 63 people found that taking an average dose of 209 mg of gingko biloba daily helped treat antidepressant-related sexual dysfunction low levels of desire, arousal, and/or pleasure in 84% of participants (27).

However, several other studies have shown that gingko biloba had little to no impact on libido or other aspects of sexual dysfunction (28, 29, 30).

Gingko biloba may treat various aspects of sexual dysfunction because it can raise levels of nitric oxide. However, studies are inconsistent.

L-citrulline is an amino acid naturally produced by your body.

Your body then converts it into L-arginine, which helps improve blood flow by producing nitric oxide to dilate your blood vessels. This, in turn, may treat erectile dysfunction (31).

For example, a small, monthlong study in 24 men with mild erectile dysfunction found that taking 1.5 grams of L-citrulline daily significantly improved symptoms in 50% of participants (32).

In another 30-day study in men, taking a daily combination of 800 mg of L-citrulline and 300 mg of trans-resveratrol improved erectile function and hardness, compared with the placebo treatment (33).

Trans-resveratrol, commonly known as resveratrol, is a plant compound that functions as an antioxidant and is linked to numerous health benefits.

L-citrulline is available as a dietary supplement in capsule or powder form but is naturally present in foods like watermelon, dark chocolate, and nuts.

L-citrulline may aid men with erectile dysfunction because it can raise blood nitric oxide levels.

Several other foods and supplements are commonly promoted as libido-boosting. However, they dont have as much supporting evidence.

Here are several foods that may boost your libido:

Many other foods and supplements may boost libido, but theyre supported by less scientific evidence.

If youre looking to boost your sex drive, youre not alone.

A few foods and supplements may even act as aphrodisiacs, including tribulus, maca, red ginseng, fenugreek, saffron, gingko biloba, and L-citrulline.

Due to limited human research, its unclear how these foods and supplements compare with pharmaceutical libido boosters like Viagra.

That said, most of these are well tolerated and widely available, making them easy to incorporate into your daily routine.

Keep in mind some of these libido-boosting foods and supplements may interact with certain drugs. If you take medication, you may want to consult a medical professional beforehand.

Continue reading here:

Nature's Viagra: 7 Foods and Supplements to Boost Your Libido - Healthline

Resveratrol is a plant compound, also known as polyphenol, which helps protect the plant when injured, and to fight off bacteria and fungi. The best food sources of this compound are the skin of grapes, berries, and peanuts. In fact, red wine has become popularized as 'healthy' because of the resveratrol it contains; however, compared to the unhealthy amounts of alcohol, the amount of resveratrol it contains is minimal.

Fig 1. Resveratrol

History

The first time, resveratrol was discovered by the Japanese, when they isolated this compound from plant roots in 1940's. However, it wasn't until 1992 that it became popular, when its presence in wine was suggested as a plausible explanation for its heart protective effects. As a result, in the past decade many fitness supplements have added this compound as a performance enhancing ingredient.

How it Works

The mechanisms of action of resveratrol are not fully understood, but it appears to mimic biochemical effects of calorie restriction. As a matter of fact, studies have shown that it activates Sirtuin 1, PGC-1a, and it improves the mitochondria's functionality.

Bodybuilding

When a bodybuilder comes off cycle, their Luteinizing hormone (LH) is suppressed and their testosterone drops as the hormone esters leave the body, allowing estrogen to fluctuate wildly up or down. Even with a comprehensive post cycle therapy (PCT), the steroid user is left exposed in between cycles to catabolism and estrogen rebounds. We call this dangerous period 'bridging'.

During a 'bridge' gains can be difficult, as the body is trying to balance itself out. Therefore, resveratrol's ability to raise testosterone levels, without suppressing LH, makes it a perfect compound to run during this period. In fact, a Korean study showed that after 28 days on resveratrol, subjects' testosterone levels increased by up to 50%.

In addition, resveratrol's benefits come into play during a bridge because it is one of the few natural compounds in existence that can boast being both a selective estrogen receptor modulator (SERM) and an aromatase inhibitor (AI). As a result, you get a bump in LH, testosterone, and it lowers estrogen.

Moreover, its anti-oxidant properties and organ protecting benefits will help cleanse out the body further, so the steroid user can recover fully before their next steroid cycle.

There is one property of resveratrol that deserves special attention and offers even more benefits for all athletes, whether they use steroids or not. A Canadian study showed that resveratrol improved endurance by an average of 21%.

Other Benefits

There has been extensive research on resveratrol that showed numerous additional benefits.

Side Effects

Clinical studies have shown no issues when resveratrol is used for long periods of time. However, as with any supplement, you should never abuse it.

Dosage

Try to eat more grapes, berries and natural peanut butter. Then add 25-50 milligrams (mgs) a day of resveratrol from supplementation.

Where to find it

As mentioned above, it would take a large amount of wine, or other foods, to get the benefits you want from resveratrol. Therefore, the best way to take advantage of this compound is through supplementation.

One supplement, that is designed specifically for athletes and for bodybuilders in between cycles is called BRIDGE by N2BM.com. It contains 25mgs per serving of resveratrol and 9 other ingredients, all designed to help you 'bridge' from one cycle to the other.

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Resveratrol - Evolutionary.org

Grapes and Grape Juice

Both grapes and grape juice are rich sources of resveratrol, a phytochemical well studied for anti-cancer effects.

The skin of the grape contains the most resveratrol. Resveratrol is in red, purple and green grapes, the amount depends much more on growing conditions than on color or type of grape.

Red wine also contains resveratrol. However, with AICRs research reports finding that alcohol is associated with increased risk for cancers of the mouth, pharynx and larynx, esophagus, breast and colon and rectum (in men), wine is not a recommended source of resveratrol.

Studies suggest that polyphenols in general and resveratrol, in particular, possess potent antioxidant and anti-inflammatory properties. In laboratory studies, resveratrol prevented the kind of damage known to trigger the cancer process in cell, tissue and animal models.

Other laboratory research points to resveratrols ability to slow the growth of cancer cells and inhibit the formation of tumors in lymph, liver, stomach and breast cells. Resveratrol has also triggered the death of leukemic and colon cancer tumors.

In one series of studies, resveratrol blocked the development of skin, breast and leukemia cancers at all three stages of the disease (initiation, promotion and progression).

AICR has funded research on the following topics relating tograpes and the cancer-fighting components they contain. You can search for relevant AICR-funded studies performed to date on our AICR Grants:

Read the full list of AICRs Recommendations for Cancer Prevention.

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foodsthatfightcancer_grapes_and_grape_juice | American ...

After some debate, Harvard Medical School researchers are saying they have confirmed that compound resveratrol that's found in red wine does provide anti-aging benefits.

The study, which was published on March 8 in Science, shows that resveratrol stimulates production of SIRT1, a serum that blocks diseases by speeding up the cell's energy production centers known as mitrochondria.

Researchers have also figured out which gene allows resveratrol to produce SIRT1, and believe that some drugs currently in clinical trials may be able to provide the same anti-aging benefits as well.

"In the history of pharmaceuticals, there has never been a drug that binds to a protein to make it run faster in the way that resveratrol activates SIRT1," senior author David Sinclair, Harvard Medical School professor of genetics, said in a press release. "Almost all drugs either slow or block them."

Resveratrol is a naturally-occuring polyphenols antioxidant that is found in some plant products like grapes and cocoa. It is categorized as a phytoalexin, an antimicrobial compound that is produced by plants to protect them from rough environments like excessive ultraviolet light, infections and climate changes.

Resveratrol has been linked to protection against obesity and diabetes, a reduced risk for blood clotting and a way to lower "bad" LDL cholesterol, due to the compound's ability to dilate blood vessels, increase nitric oxide and block the stickiness of platelets. However, some research came into question when Dr. Dipak K. Das, director of the cardiovascular research center at the University of Connecticut who led several reseveratrol studies, was accused of making up results in January 2013.

There was also a controversy behind whether SIRT1's production was actually influenced by resveratrol. Earlier studies have used a man-made chemical group which glowed brighter the more SIRT1 activity went up. Without this chemical, the experiments didn't work. Some scientists believed that because of this, it meant that SIRT1's activity was only a laboratory construct and didn't exist in nature.

"We had six years of work telling us that this was most definitely not an artifact," Sinclair, who initially published a study in 2006 linking resveratrol to SIRT1 and longevity in mice using that man-made chemical, said. "Still, we needed to figure out precisely how resveratrol works. The answer was extremely elegant."

To prove that there was a link between resveratrol and SIRT1, scientists discovered that the man-made chemical was actually close to three amino acids that were naturally found in cells, one of which is tryptophan, the chemical thought to make people drowsy after eating turkey. Instead of using the florescent chemical, researchers used a tryptophan residue in a test tube to see if it would create more SIRT1, which it did.

Then, Sinclair and his team looked at 2,000 mutants of the gene responsible for SIRT1 to find out how resveratrol worked, and found one mutation that stopped resveratrol's effects by swapping out one of the 747 amino acid residues.

After they found where this mutation was found on SIRT1-creating gene and how to control it, researchers replaced the normal SIRT1 gene in manufactured muscle and skin cells with the one that stopped resveratrol's effect. They then introduced resveratrol and some other medications in clinical trials. Resveratrol and some of the medications were able to speed up mitrochondria by activating more SIRT1 in normal cells, but the mutated cells were unaffected by the substances.

"This was the killer experiment," said Sinclair. "There is no rational alternative explanation other than resveratrol directly activates SIRT1 in cells. Now that we know the exact location on SIRT1 where and how resveratrol works, we can engineer even better molecules that more precisely and effectively trigger the effects of resveratrol."

It is important to note that Sinclair is a co-founder and scientific advisor of Sirtris, a GlaxoSmithKline company. Sirtris currently has a number of sirtuin (SIRT1)-activating compounds in clinical trials.

Sinclair told the Telegraph in a separate interview that he wants to continue the studies to see if reveratrol can help people who are already really healthy.

"Things there are also looking promising. We're finding that ageing isn't the irreversible affliction that we thought it was," he commented. "Some of us could live to 150, but we won't get there without more research."

Many agree that the information is promising.

"This is not weak evidence at this point," Leonard Guarente, a biologist at the Massachusetts Institute of Technology and a Sirtris scientific advisory board member, added to the Los Angeles Times."You would really bet the ranch on this one."

"It might bring together the different views so we can move forward," Brian Kennedy, president and chief executive of the Buck Institute for Research on Aging in Novato, Calif., added in a press release. Kennedy previously questioned the results of studies using resveratrol and yeast. "This is how science works."

Read more:

Resveratrol does provide anti-aging benefits, study shows ...

What other names is Resveratrol known by?3,5,4' TriHydroxy-Transstibene, (E)- 5-(4-hydroxystyryl)benzene-1,3-diol, 3,4',5-stilbenetriol, 3,5,4' -trihydroxystilbene, 3,4',5-trihydroxystilbene, 3,5,4'-trihydroxy-trans-stilbene, Cis-Resveratrol, Extrait de Vin, Extrait de Vin Rouge, Kojo-Kon, Phytoalexin, Phytoalexine, Phytoestrogen, Phyto-œstrogne, Pilule de Vin, Protykin, Red Wine Extract, Resvratrol, Resveratrols, Resvratrols, RSV, RSVL, Stilbene Phytoalexin, Trans-Resveratrol, Trans-Resvratrol, Wine Extract, Wine Pill.Resveratrol is a chemical found in red wine, red grape skins, purple grape juice, mulberries, and in smaller amounts in peanuts. It is used as a medicine.

People use resveratrol for "hardening of the arteries" (atherosclerosis), lowering "bad" (LDL) cholesterol levels, increasing "good" (HDL) cholesterol levels, and preventing cancer and heart disease. It is also used for symptoms of a lung disorder "chronic obstructive pulmonary disease" and to improve the health of the liver in people with liver damage not caused by drinking alcohol. Resveratrol is used to improve glucose levels in the blood in people with diabetes, to reduce body fat in people with a condition called metabolic syndrome, and to slow signs of aging in the skin.

Some people apply resveratrol to their skin to treat acne.

Resveratrol is used as a nasal spray for symptoms of seasonal allergies (hay fever).

Possibly Effective for...

Possibly Ineffective for...

Insufficient Evidence to Rate Effectiveness for...

In children, resveratrol is POSSIBLY SAFEwhen sprayed in the nostrils for up to 2 months.

Bleeding disorders: Resveratrol might slow blood clotting and increase the risk of bleeding in people with bleeding disorders.

Hormone-sensitive condition such as breast cancer, uterine cancer, ovarian cancer, endometriosis, or uterine fibroids: Resveratrol might act like estrogen. If you have any condition that might be made worse by exposure to estrogen, don"t use resveratrol.

Surgery: Resveratrol might increase the risk of bleeding during and after surgery. Stop using resveratrol at least 2 weeks before a scheduled surgery.

Some medications are changed and broken down by the liver. Resveratrol might decrease how quickly the liver breaks down some medications. In theory, taking resveratrol along with some medications that are broken down by the liver may increase the effects and side effects of some medications.

Some medications changed by the liver include chlorzoxazone, theophylline, and bufuralol.

Some medications are changed and broken down by the liver. Resveratrol might decrease how quickly the liver breaks down some medications. In theory, taking resveratrol along with some medications that are broken down by the liver may increase the effects and side effects of some medications.

Some medications changed by the liver include clozapine (Clozaril), cyclobenzaprine (Flexeril), fluvoxamine (Luvox), haloperidol (Haldol), imipramine (Tofranil), mexiletine (Mexitil), olanzapine (Zyprexa), pentazocine (Talwin), propranolol (Inderal), tacrine (Cognex), zileuton (Zyflo), zolmitriptan (Zomig), and others.

Some medications are changed and broken down by the liver. Resveratrol might decrease how quickly the liver breaks down some medications. In theory, taking resveratrol along with some medications that are broken down by the liver may increase the effects and side effects of some medications.

Some medications changed by the liver include theophylline, omeprazole, clozapine, progesterone, lansoprazole, flutamide, oxaliplatin, erlotinib, and caffeine.

Some medications are changed and broken down by the liver. Resveratrol might decrease how quickly the liver breaks down some medications. In theory, taking resveratrol along with some medications that are broken down by the liver may increase the effects and side effects of some medications.

Some medications changed by the liver include amitriptyline (Elavil), carisoprodol (Soma), citalopram (Celexa), diazepam (Valium), lansoprazole (Prevacid), omeprazole (Prilosec), phenytoin (Dilantin), warfarin, and many others.

Some medications are changed and broken down by the liver. Resveratrol might decrease how quickly the liver breaks down some medications. In theory, taking resveratrol along with some medications that are broken down by the liver may increase the effects and side effects of some medications.

Some medications changed by the liver include acetaminophen, chlorzoxazone (Parafon Forte), ethanol, theophylline, and anesthetics such as enflurane (Ethrane), halothane (Fluothane), isoflurane (Forane), methoxyflurane (Penthrane).

Some medications are changed and broken down by the liver. Resveratrol might decrease how quickly the liver breaks down some medications. In theory, taking resveratrol along with some medications that are broken down by the liver may increase the effects and side effects of some medications. However, some early research shows conflicting results.

Some medications changed by the liver include some calcium channel blockers (diltiazem, nicardipine, verapamil), chemotherapeutic agents (etoposide, paclitaxel, vinblastine, vincristine, vindesine), antifungals (ketoconazole, itraconazole), glucocorticoids, alfentanil (Alfenta), cisapride (Propulsid), fentanyl (Sublimaze), lidocaine (Xylocaine), losartan (Cozaar), fexofenadine (Allegra), midazolam (Versed), and otherslovastatin (Mevacor), ketoconazole (Nizoral), itraconazole (Sporanox), fexofenadine (Allegra), triazolam (Halcion), and many others.

Resveratrol might slow blood clotting. Taking resveratrol along with medications that also slow clotting might increase the chances of bruising and bleeding.

Some medications that slow blood clotting include aspirin, clopidogrel (Plavix), diclofenac (Voltaren, Cataflam, others), ibuprofen (Advil, Motrin, others), naproxen (Anaprox, Naprosyn, others), dalteparin (Fragmin), enoxaparin (Lovenox), heparin, warfarin (Coumadin), and others.

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Natural Medicines Comprehensive Database rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, and Insufficient Evidence to Rate (detailed description of each of the ratings).

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Resveratrol Effectiveness, How It Works, and Drug ...

Resveratrol is a compound that occurs naturally in certain foods, including the skin of grapes and red wine. It is also found in grape juice, peanuts, cocoa, and berries such as blueberries and cranberries.

Researchers interest in resveratrol was sparked when studies in the 1990s found health benefits to drinking moderate amounts of red wine, including the possibility of a lower risk of dementia. Ongoing clinical studies into its possible benefits in Alzheimers patients, however, is limited.

Scientists are still trying to understand how resveratrol works in the body, and whether it might help prevent or treat Alzheimers disease.

In some preclinical studies, resveratrol decreased the amount of beta-amyloid protein in cells grown in laboratories and in the brains of mice by promoting thebreakdown of the protein. Beta-amyloid forms the plaques that are characteristic of Alzheimers disease.

Another theory is that resveratrol mimics the effect of restricting calorie intake. A low-calorie diet has been found in animal studies to prevent or delay the onset of age-related diseases, including Alzheimers.A low-calorie diet appears to activate a class of enzymes known as sirtuins, and resveratrol seems to have the same effect.

A Phase 2 clinical trial (NCT01504854), completed in 2014,included 119 patients with mild to moderate Alzheimers disease. Participants took capsules containing placebo or resveratrol, starting with a dose of 500 mg a day and increasing to 1 gram twice a day.

Researchers measured participants blood levels of beta-amyloid-40, a protein that typically decreases in the blood as Alzheimers disease progresses. Patients treated with resveratrol showed little to no change in beta-amyloid-40 blood levels, while a decrease was observed in the placebo group.

An analysis of 19 participants from each of the resveratrol and placebo groups alsoshowed evidence that resveratrol restores the integrity of the blood-brain barrier, whose role is therestricts the movement of molecules and cells between the blood system and the brain.

Patients treated with resveratrol had lower levels in their cerebrospinal fluid (the fluid that surrounds the brain and spinal cord) of a protein that at high levels breaks down blood-brain barrier.

Another clinical trial (NCT01716637), sponsored by the Life Extension Foundation, tested the effect of a multi-ingredient dietary supplement that included resveratrol in about 12 participants with mild to moderate Alzheimers disease. The supplement was administered alone or in addition toEnbrel(etanercept), a medicine used to treat autoimmune disorders, which was injected into tissues close to the spinal column (peri-spinally). The participants scores on cognitive tests were tracked. The Phase 1 pilot study was completed in May 2016 but results had not been reported as of early 2018.

***

Alzheimers News Today is strictly a news and information website about the disease. It does not provide medical advice, diagnosis or treatment. This content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. Never disregard professional medical advice or delay in seeking it because of something you have read on this website.

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Resveratrol - Alzheimer's News Today

Longevinex is more than plain resveratrol

Featured

To learn more about resveratrol and longevity go to ResveratrolNews.com

We also added nutrients that synergize resveratrols anti-aging capabilities of Longevinex

Longevinex cites its own proprietary studies in both animals and humans to substantiate its claims

Longevinex only resveratrol-based nutraceutical to pass toxicity testing.

Journal: Food Chemistry Toxicology Sept 2013, Sept 2013

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Longevinex molecularly mimics a calorie-restricted diet; activates 9-times more longevity genes than plain resveratrol.

Journal: Experimental Gerontology, Sept 2008

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Longevinex dilates (widens) arteries and improves blood flow upon physical exertion twice that of plain resveratrol.

Journal: Nutrition Research, Nov 2011

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Longevinex protects the rodent heart from experimentally-induced heart attack better than plain resveratrol.

Journal: Experimental Clinical Cardiology, Winter 2010

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100 mg (produces 9-fold greater biological effect than equal dose of plain resveratrol due to synergistic action with other molecules

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Resveratrol based synergy blend

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Resveratrol supplement, dosage and health benefits

What is Resveratrol?Resveratrol is a flavonol belonging to the group of flavonoids. It is produced by the plant as a defence against diseases.DistributionResveratrol is present in many plants and fruits, including red grapes, eucalyptus, spruce, blueberries, mulberries, peanuts, giant knotweed. Also red wine contains a lot of it. The longer the grape juice is fermented with the grape skins the higher the resveratrol content will be. Health Benefits of ResveratrolResveratrol is an antioxidant but its antioxidant properties are weaker that those of quercetin and epicatechin. It has anticancer properties and inhibits lipid peroxidation of low-density lipoprotein and prevents the cytotoxicity of oxidized LDL. Resveratrol also increases the activity of some antiretroviral drugs in vitro.

AntioxidantIn vitro studies have shown that resveratrol inhibits the oxidative damage caused by the heavy metal cadmium. The antioxidant activity of resveratrol reduces damage to endothelial cells exposed to nitrite radicals and protects skin cells against damage caused by UV radiation.

AnticancerThe antioxidant action of resveratrol helps to prevent damage to DNA but it also influences the transcriptions of genes responsible for redox metabolism and inhibits proliferartion of cancer cells. Resveratrol appears to decrease tumor promotion activity by inhibiting the enzyme cyclooxygenase-1, which converts arachidonic acid to substances that promote tumor growth. In vitro experiments provide support for resveratrol to serve as a candidate preventive agent against prostate cancer, but in vivo effects of resveratrol and the mechanisms of action of resveratrol on prostate cancer prevention remain largely unknown.

Benefits for diabetesResveratrol may be benificial for diabetes. Administration of resveratrol may protect against oxidative damage caused by high glucose levels. It also reduces diabetic neuropathic pain.

Heart healthResveratrol protects our heart and blood vessels by directly scavenging oxidants, which could cause oxidation of lipids, and by preventing apoptosis of endothelial cells. It may also help to prevent heart damage after a cardiac arrest. Reduced platelet aggregation has been attributes to resveratrol, thereby reducing the risk of atherosclerosis.

Increase of lifespanTests with animals have shown that that high food intake reduces lifespan. One study showed that resveratrol was able to able to increase the life span of mice on a high calorie diet.

AntitoxicMany studies on animals have shown antitoxic effects of resveratrol. Resveratrol was able to reverse damages caused by the administration of the chemotherapeutic drug bleomycin. Resveratrol also helped to reduce brain damage and oxidative damage of the liver during ethanol intoxication. It also reduced kidney damage of rats treated with the antibiotic gentamicin.

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Resveratrol - Phytochemical

Big Pharma is drooling over the prospect of getting it all to themselves.

Resveratrol, a substance found in the skin of red grapes as well as in pomegranates and Japanese knotweed, has been a popular dietary supplement for many years. It has anti-inflammatory and antiviral properties, possibly the potential to extend life, prevent several different cancers, protect the heart, ameliorate common diabetes symptoms, and control plaque in the brain and otherwise help with Alzheimers disease. And that isnt even a complete list. Its clear why drug companies are excited.

Resveratrol is widely available as a dietary supplementbut may not be for long if we are not vigilant. A new study has thrown the excitement over resveratrol into high gear. Results from ten years of research have just been published by David Sinclair, a Harvard Medical School genetics professor and the studys senior author. The research validated earlier findings that resveratrol may protect against age-related diseases because it turns on the SIRT1 gene that recharges mitochondria.

Sinclairs earlier research was partly discounted by other scientists in 2009 and 2010. They suspected that resveratrol might only seem to activate the SIRT1 gene because studies used a synthetic fluorescent chemical to track the effect. Since these synthetic chemicals are not found in nature, they reasoned, the experiment is not reproducible in humans. In this study, however, Sinclair used naturally occurring amino acids to track the benefits, which affirmed the compounds benefits.

Sinclair is not a disinterested party. He is the founder of Sirtris Pharmaceuticals, which focuses on developing resveratrol drugs, that is drugs that will mimic resveratrols effects with new and thus patentable molecules. Pharmaceutical giant GlaxoSmithKline (GSK) acquired Sirtris in 2008 for $720 million. GSK subsequently abandoned its work on resveratrol-based drug SRT501 because the drug didnt appear to work on cancer patients and worsened kidney damage. Its likely, however, that the new findings will prompt GSK to restart its work on a resveratrol-based drug; resveratrol is already the subject of at least two dozen clinical trials.

Because Resveratrol is also the subject of an investigational new drug (IND) application, GSK could petition FDA to ban natural resveratrol. Yes, that s how warped the law is. Apply for FDA approval for something synthetic, new-to-nature, and thus potentially much more dangerous, and you can then try to ban the natural substance on which your product was based.

This is governed by a provision in the law, as we explained last year. There is an absolute prohibition against banning the natural substance if it is grandfathered (that is, marketed before 1994) or if the FDA has accepted a New Dietary Ingredient (NDI) notification from supplement manufacturers.

Supplement companies have tried to file NDIs for resveratrol, but the FDA has rejected them all, stating that an IND had already been filed, so they wont accept an NDI. Despite resveratrol being a natural component of food and a constant part of the food supply, it may be hard to prove that it was marketed before 1994. This, of course, merely reveals the illogic of the grandfathering process: it was put in place as a means of proving the safety of an ingredient, but instead its being used to protect the pharmaceutical industry.

New drug applications (INDs) are confidential, but we can make an educated guess that Sirtris Pharmaceuticals is one of the companies that filed an IND since they have already started clinical drug trials (an IND is required before clinical drug trials). If they are successful, resveratrol will then be available in an expensive, synthetic drug form, likely requiring a prescription at a very high cost and a disease condition for access. It will be tempting for the drug company to then try to have the FDA ban the natural form of resveratrol. It is our job to prevent that by making it painful for both the company and the FDA.

In this context, lets remember what happened to pyridoxamine, one of the three primary natural forms of vitamin B6. Biostratum, the North Carolina-based manufacturer of a planned pyridoxamine-based drug called Pyridorin, petitioned the FDA for market exclusivity, and FDA kowtowed, effectively prevented any substance containing pyridoxamine from being marketed as a dietary supplement. To date no drug has even appeared, so we have neither natural B vitamin nor drug, an outcome that is all too typical of FDA illogic and misuse of power.A similar petition has been filed regarding P5P, the natural form of B6 that is most bio-available. All other forms of B6 must be converted by the body to this form to be used, and without it we would all die. Is this really something to ban and make into an exclusive, prescription-only drug? (If you have not already done so, please send your message to FDA and Congress to make sure P5P remains available as a supplement.)

If the dietary supplement version of resveratrol becomes threatened, rest assured that ANH-USA will be with you on the front lines, fighting to maintain your access to this amazing nutritional ingredient.

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New Study Touts Big Health Benefits of Resveratrol

Resveratrol acts as an antioxidant and inhibits oxidation of low density lipoproteins (LDL)(21), plateletaggregation, and eicosanoid synthesis(4). It also induces nitric oxide (NO) production(24)(25) and increases arterial blood flow(8). These actions may contribute to its purported cardiovascular health benefits.

Resveratrol acts as an anti-inflammatory agent by inhibiting cyclooxygenase (COX) activity(26). It has been shown to decrease C-reactive protein and tumor necrosis factor, and to increase anti-inflammatory interleukin-10 and intercellular adhesion molecule-1 in humans(5). Resveratrol decreases oxidative stress and improves insulin sensitivity by increasing protein kinase activities(10). It decreases circulating insulin-like growth factor-1 (IGF-I) and IGF-binding protein-3 (IGFBP-3) levels(27) which may account for its antidiabetic effects in humans.

Preliminary data suggest that resveratrol increases the life span of yeast cells by activating sirtuins(1)(2). Recent study shows it inhibits human Sirt3 and stimulates Sirt5, in addition to Sirt1(28).

In vitro and animal studies show that resveratrol has anticancer activities. It inhibits proliferation of cancer cells via apoptosis and by exerting anti-estrogenic effects(14)(15)(16)(17). However, contradictory data from other studies showed that it acts as a phytoestrogen and could activate genes that are normally regulated by estrogens(18) or androgens(19).

Trans-resveratrol appears to decrease methylation of the tumor suppressor gene RASSF-1alpha in women at increased breast cancer risk(29). In addition, reductions in breast cancer cell migration and invasion were observed after treatment with resveratrol(30)(31). Resveratrol growth factor heregulin-beta1 (HRG-beta1) mediated matrix metallopeptidase 9 (MMP-9) expressions in human breast cancer cells(30).

Resveratrol may help reduce prostate tumorigenesis through a reduction inprostatic levels of mTOR complex 1 (mTORC1) activity and increased expression of SIRT1(32). Another study demonstrated that resveratrol modulates steroid hormone-dependent pathways to inhibit prostate cancer cell growth. However, resveratrol also increases angiogenesis and inhibitsapoptosis in vivo(19).

In an animal model, resveratrol downregulated p21and upregulated cyclin E leading to S-phase accumulation and apoptosis in neuroblastoma cells(14). Italso inhibitedCYP1A1, CYP1A2, and CYP1B1 enzymesin tumor cells, perhapsexerting antitumor effects as some of these enzymes are known to be involved in the activation of procarcinogens and toxins(22)(23).

Protective effects of resveratrol against doxorubicin-induced cardiotoxicity are due to upregulation of SIRT1-mediated p53 deacetylation.(20). It also protects against cisplatin-induced cardiotoxicity through the suppression of oxidative stress(19).

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Resveratrol | Memorial Sloan Kettering Cancer Center

Back pain could be caused by sleeping in the wrong position, having bad posture, or even by having a minor injury.

In most cases, back pain isnt anything to worry about, and itll get better by itself within a few weeks or months.

One of the easiest ways to limit your chances of backache is to add red grapes to your diet, according to ChiroCare of Florida's chiropractor Dr Michael Levine.

Grapes contain an antioxidant-like compound known as resveratrol, which helps to relieve back pain.

READ MORE: Lower back pain - the signs your pain could be something more serious

"The powerful compound present in red grapes, resveratrol, has gained popularity thanks to its antioxidant properties.

"But, resveratrol can also help block enzymes that contribute to tissue degeneration, which can lead to cartilage damage, and subsequently lead to back pain.

"Other foods rich in resveratrol include raspberries, cranberries, and red wine."

Other than red grapes, you could also lower your risk of back pain by drinking green tea.

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Back pain - the best fruit to protect your spine and prevent lower backache - Express