Panel recommends no more PSA test as a screening tool

Wonder how the laboratory and urology community will do with this information:

U.S. Panel Says No to Prostate Screening for Healthy Men

Apparently the serum test as well as the rectal exam and ultrasound are not effective either. This is for healthy men without symptoms only.  Not sure what the effective screening tool is then because you screen healthy, not ill individuals.  Certain to be a lot of pushback, fighting, action groups, political battles and contradictory data to this new recommendation. Stay tuned.

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Dark Daily visits the anatomic pathology department and clinical laboratory at University Health Network

Dark Daily editor Robert Michel writes about the successes of digital pathology in Ontario from a recent visit.

DATELINE: Toronto, Ontario, Canada—Here in the downtown area of Ontario’s largest city is a healthcare organization known as University Health Network (UHN) that operates one of the province’s larger consolidated clinical laboratory organizations. In support of its hospitals, the UHN Laboratory provides an impressive menu of medical laboratory tests.

Read entire story.

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Open Source Digital Pathology Consortium Announced

Pittsburgh, Pennsylvania, USA - October 6, 2011

The Open Source Digital Pathology Consortium, Inc. (“OpenDP”) announced its formation today at the Pathology Informatics 2011 meeting in Pittsburgh, PA. The Consortium shall be known as OpenDP.

OpenDP engages academic medical centers, research institutions, and digital pathology manufacturers to create an open source community. The community will contribute and build open source tools for digital pathology. Much of this code has been funded by federal grants and universities. These tools are open to all to use freely.

To date founding members have contributed over 70 person years of effort to open source code for the benefit of the OpenDP community. OpenDP plans to represent our community’s interests as it relates to digital pathology standards.

“With the increased digital pathology adoption at academic medical centers and research institutions,” stated Mahadev Satyanarayanan (Satya), founding Technical Director of OpenDP, “the evolution of an open source community is vital for digital pathology innovation.” Satya is the Carnegie Group Professor of Computer Science at Carnegie Mellon University, and serves as Technical Director to provide leadership for the consortium’s mission.

The founding members include:

  • Queens University
  • Robert Wood Johnson Medical School, UMDNJ, Center for Biomedical Imaging & Informatics
  • The Research Institute at Nationwide Children's Hospital
  • Yale University School of Medicine, Pathology Informatics
  • Mass General Hospital, Pathology Imaging and Communication Technology Center
  • University of Kansas Medical Center
  • University of South Florida
  • Johns Hopkins University
  • Emory University, Center for Comprehensive Informatics
  • Keck School of Medicine University of Southern California at Children’s Hospital Los Angeles
  • University of Michigan Health System, Division of Pathology Informatics
  • The University of Texas MD Anderson Cancer Center
  • Carnegie Mellon University

 

Please check http://www.opendp.org to participate and sponsor the community’s growth.

 

 

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Check out Leica Science Lab – the Knowledge Portal for Microscopy and Histology

Wetzlar, Germany. Leica Science Lab (http://www.leica-microsystems.com/science-lab), the knowledge portal of Leica Microsystems, offers scientific research and teaching material on the subjects of microscopy and histology, from the basics to specific application know-how.

Learn. Share. Contribute.

Illustrated and interactive tutorials as well as white papers explain technical rudiments all the way from specimen preparation and immunochemistry to imaging, con­trast techniques and high-end technologies such as super-resolu­tion. In addition, Leica Science Lab features scientific articles on spe­cial techniques, applications and areas of research. The content is designed to support beginners, experienced practitioners and scientists alike in their everyday work and experiments. What’s more, the range of topics offered by the portal will be continuously widened.

 

Leica_Science_Lab 

Leica Science Lab invites its readers to discuss the articles and topics presented. Users’ comments and questions will be used to improve the information on an ongoing basis. At the time of the official go-live date, 100 authors had contributed to filling the portal with in-depth content. Experts in science, methods, and techniques who would like to share their knowledge with the community are cordially invited to pub­lish their articles in Leica Science Lab.

_ _ _ _ _ _ _ _ _ _ _ _ _ _ _

Leica Microsystems is a world leader in microscopes and scientific instruments. Founded as a family business in the nineteenth century, the company’s history was marked by unparalleled innovation on its way to becoming a global enterprise.

Its historically close cooperation with the scientific community is the key to Leica Microsystems’ tradition of innovation, which draws on users’ ideas and creates solutions tailored to their requirements. At the global level, Leica Microsystems is organized in four divisions, all of which are among the leaders in their respective fields: the Life Science Division, Industry Division, Biosystems Division and Medical Division.

Leica Microsystems’ Biosystems Division, also known as Leica Biosystems, offers histopathology labor­atories the most extensive product range with appropriate products for each work step in histology and for a high level of productivity in the working processes of the entire laboratory.

The company is represented in over 100 countries with 12 manufacturing facilities in 7 countries, sales and service organizations in 19 countries and an international network of dealers. The company is headquartered in Wetzlar, Germany.

 

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Superiority of virtual microscopy versus light microscopy in transplantation pathology

Nice study in this month's Clinical Transplantation on light versus virtual microscopy. 

Increasingly studies are showing equal or superior interobserver agreement with virtual over light microscopy.  

What if we find whole slides are better than glass slides in terms of diagnostic accuracy compared with "truth" or "gold standard" diagnosis?

Clin Transplant. 2011 Sep 29. doi: 10.1111/j.1399-0012.2011.01506.x. [Epub ahead of print]

Ozluk YBlanco PLMengel MSolez KHalloran PFSis B.

Source

Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, AB, Canada Department of Pathology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey Alberta Transplant Applied Genomics Centre Department of Medicine, Division of Nephrology and Transplant Immunology, University of Alberta, Edmonton, AB, Canada.

Abstract

Virtual microscopy has begun to change conventional pathology practice. We tested the reliability of this new technology in transplantation pathology. We studied 40 kidney transplant biopsies for cause and compared reproducibility of Banff scores using virtual slides versus glass slides. Three glass slides per biopsy were scanned as high-resolution digital slides using Aperio ScanScope. Three pathologists independently reviewed the biopsies: twice by glass slides and twice by virtual slides. Eleven histopathological lesions were scored and used to construct diagnosis according to Banff criteria. The intra-observer reproducibility of Banff scores was substantially good using either virtual slides or glass slides (mean ?: 0.69 vs. 0.64, p?>?0.05). The inter-observer reproducibility of Banff scores was better in virtual slides than in glass slides (mean ?: 0.42 vs. 0.28, p?<?0.001). Among the lesions, transplant glomerulopathy scoring by virtual slides showed the highest inter-observer reproducibility, with a similar accuracy to glass slides. The agreement for acute rejection between virtual and glass slides was not different from the agreement between two readings of glass slides. Thus, virtual microscopy is a reliable and more reproducible technology and has several advantages over glass slides, e.g., accessibility via internet, no fading. We recommend virtual microscopy for transplant diagnostics, including utilization for clinical trials.

 

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Check Out Leica Microsystems at Pathology Informatics 2011

05 October - 06 October

Location: Pittsburgh Wyndham Grand
600 Commonwealth Place, Pittsburgh (US)

Pathology Informatics involves collecting, examining, reporting, and storing large complex sets of data derived from tests performed in clinical laboratories, anatomic pathology laboratories, or research laboratories in order to improve patient care and enhance our understanding of disease-related processes.

Pathology Informaticians seek to continuously improve existing laboratory information technology and enhance the value of existing laboratory test data, and develop computational algorithms and models aimed at deriving clinical value from new data sources.

Visit the Leica Microsystems' booth #6 to view the Leica SCN400 slide scanner for digital pathology which makes work faster, more reliable, and flexible. Scanning and digitizing slides is accomplished in amazing speed.

The system’s patented dynamic focus tracking enables the scanner to not only be faster, but reveal more of a specimen’s details. This can reduce the number of failed scans as compared to conventional focusing.

For Research Use Only in the U.S.A. and the People's Republic of China.

Booth: 6

Exhibition Hours: 

Wednesday, October 5, 2011
10:20 am - 11:20 am
3:20 pm - 4:05 pm
5:30 pm - 7:30 pm

Thursday, October 6, 2011
10:20 am - 11:20 am
3:30 pm - 4:10 pm

 

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Speech Pathology: Approach to Assessment

A speech and language pathologist and an occupational therapist discuss their experiences working together helping children with neurodevelopmental delays, providing strategies, techniques, and tips to use in an intervention setting Series: MIND Institute Lecture Series on Neurodevelopmental Disorders [11/2008] [Health and Medicine] [Show ID: 14649]

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Speech Pathology: Approach to Assessment

Basic Medical Pathology: Morphological Expressions of Cell Injury

National Institutes of Health Lister Hill National Center for Biomedical Communications Basic Medical Pathology: Morphological Expressions of Cell Injury AVA19672VNB1 - 1994 The video tape defines and describes injuries sustained by cells when they are exposed to stress and are unable to adapt. The results of cell injury are shown with photomicrographs, organ photographs, and electron micrographs of normal and injured cells.

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Basic Medical Pathology: Morphological Expressions of Cell Injury