SAN DIEGO--(BUSINESS WIRE)--Pipeline Therapeutics, a biopharmaceutical company focused on the development and commercialization of first-in-class small molecules for neuroregeneration, today announced the appointment of Julie Iwashita as the companys Vice President of Clinical Operations. Ms. Iwashita brings more than 30 years of experience guiding global neurology and other clinical development programs through the U.S. Food and Drug Administration (FDA) and other global health authorities.

I am delighted to welcome Julie to Pipeline Therapeutics to spearhead our clinical development efforts, said Carmine Stengone, President & CEO of Pipeline Therapeutics. Julies extensive experience in managing drug candidates through the clinic, across a variety of therapeutic areas, will benefit us greatly as we move our neuroregenerative candidates through clinical studies and assemble the data packages needed for eventual NDA submissions.

I am delighted to be joining the Pipeline team, just as the companys lead program, PIPE-505 for sensorineural hearing loss, is progressing through a proof-of-concept Phase 1/2a study, and as PIPE-307 enters the clinic, both candidates with great potential to help patients with unmet medical needs, said Ms. Iwashita. I believe Pipeline Therapeutics is well-positioned to transform the current treatment of neurological disorders, based on its exciting and proprietary technology covering synaptogenesis, remyelination and axonal repair.

Julie most recently served as Vice President of Clinical Operations for Cirius Therapeutics, a clinical-stage pharmaceutical company focused on the development of treatments for liver and metabolic diseases. Previously she served as Executive Director, Clinical Operations at Kodiak Sciences Inc., (NASDAQ: KOD). Prior to Kodiak, Julie served as Executive Director of Clinical Development at Laguna Pharmaceuticals and before that at Sorbent Therapeutics. Prior to Sorbent, Julie was Senior Director of Clinical Development at MAP Pharmaceuticals, Proteolix, Inc. and Affymax, Inc. (OTCMKTS: AFFY). Julie has served as a consultant for multiple private and public biotech companies exploring neurological disorders including age-related macular degeneration, spinal cord injury, and migraine headaches. She has also managed clinical programs at Genitope, Aviron, Amgen and Syntex in therapeutic areas including renal, cardiovascular, and oncology.

Julie holds a bachelors degree in human biology from Stanford University.

About Pipeline Therapeutics

Pipeline Therapeutics is a biopharmaceutical company focused on the development and commercialization of first-in-class small molecules for neuroregeneration, including synaptogenesis, remyelination and axonal repair. The company's lead clinical program, PIPE-505, is currently enrolling patients in a phase 1/2a study to treat sensorineural hearing loss (SNHL) associated with speech-in-noise disability. The company also has a portfolio of programs addressing a range of neurological disorders, including development candidate PIPE-307 which is focused on remyelination to treat multiple sclerosis. For more information, please visit http://www.pipelinetherapeutics.com.

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Pipeline Therapeutics Appoints Julie Iwashita as Vice President of Clinical Operations - Business Wire

BUFFALO, N.Y. A University at Buffalo researcher recently co-led a panel of 16 international experts on myasthenia gravis (MG) to revise and expand recommendations for managing the disease. Their paper was published in the journal Neurology on Nov. 3.

Gil I. Wolfe, MD, Irvin and Rosemary Smith Chair of the Department of Neurology in the Jacobs School of Medicine and Biomedical Sciences at UB and president of UBMD Neurology, served as co-chair of the panel. He also co-chaired the same panel in 2016, when the guidelines were originally developed.

The new guidance for clinicians is based on the latest evidence in the literature. This updated formal consensus guidance provides recommendations to clinicians caring for MG patients worldwide.

Some wealthy countries have established their own guidelines, but most of the world cannot do that, Wolfe said.The international panel, using the UCLA/RAND Appropriateness Methodology to achieve a formal consensus, hopes to fill that void, providing a treatment/management framework for health care providers, industry, insurers and the patient community.

MG is a rare autoimmune disease affecting neuromuscular function. As many as 60,000 Americans have been diagnosed with MG, and its incidence is increasing as a result of improved diagnostic techniques and an aging population. Symptoms of MG include droopy eyelids; blurred or double vision; difficulty speaking, swallowing and breathing; and muscle weakness.

One of the main revisions to the recommendations encourages thymectomy (surgical removal of the thymus gland) in the largest subpopulation of MG patients. This change is based on a clinical trial for which Wolfe was the principal investigator. Results of that trial were published in the New England Journal of Medicine in 2016 and in The Lancet Neurology in 2019.

A new recommendation was also developed for the use of eculizimab, a complement inhibitor that is the first FDA-approved immunotherapy for MG.

The panel also revised recommendations for the use of rituximab and methotrexate, as well as for early immunosuppression in ocular MG and MG associated with immune checkpoint inhibitor treatment.

In addition, there are some warnings in the recommendations pertaining to worsening MG clinical status in regard to certain therapies that have been touted for use in COVID-19, Wolfe said.

A list of panel participantsand their institutions is available in thepaper.

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UB researcher co-chairs international panel that expanded guidance for caring for patients with myasthenia gravis - UB News Center

A newly added research report by Orbis Pharma Reports evaluating various developments and eventful milestones in global Interventional Neurology Device market suggests that the aforementioned market is an emerging one with ample scope for refurbishments and developments. Inclined to render optimum investment guidance for accurate pandemic management, this versatile research report also sheds ample light on COVID-19 pandemic management and evolution guide to emerge successfully from limitations that have stunned growth progression substantially. Thorough research offerings compiled by Orbis Phrama Reports suggest that owing to favorable market conditions and rampant market opportunities in the previous decades, several market participants have directed investment aggressively towards novelties.This in-depth research report initiated by Orbis Pharma Reports equips readers with ample market advantages, allowing manufacturers to spot crucial cues pertaining to market rivalry, competition intensity. The report also allows readers to gauge into technological innovations to enable diffusion of technological advances into market investments, thus deriving maximum benefits.

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This detailed market synopsis by Orbis Pharma Reports depicting current market scenario highlights crucial details on SWOT analysis, PESTEL analysis and Porters Five Forces analytical reviews to understand market developments in real time. Market Relevant information have been professed with great detail in the report to encourage high investment returns by leading players in global Interventional Neurology Device market. The report carries out a deep analytical study to identify and understand the potential of core factors that stimulate high end growth.This high-end research report assessing the market scenario lends ample insights on various market facets concerning market segments. The segmentation concerning global Interventional Neurology Device market identifies product and service categories as vital segments. Additional segments also include applications and geographical expanse as prominent market segments harnessing revenue diversifications which also have been evaluated with great detail in this Orbis Pharma Reports presentation. This segment intensive information presented in the report influence competitive edge amongst report readers and inquisitive market participants.

Major Company Profiles operating in the Interventional Neurology Device Market:

MedtronicMedikit Co., Ltd.Penumbra, Inc.Johnson and JohnsonMicroport Scientific CorporationTerumo CorporationW.L. Gore & AssociatesMerit Medical Systems, IncStryker

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Regional Developments: an Overview:

In the following report sections, research analysts at Orbis Pharma Reports reveal an overview of various geographical developments that play crucial role in growth enablement. Several prominent growth beds available across varied regions have been identified in detail to understand vendor preferences and investment discretion besides tapping on novel growth opportunities prevalent across different regions.Across MEA, South Africa and GCC countries demonstrate promising growth potential. European nations such as Germany, Italy, France and Scandinavian countries offer immense growth potential. Across APAC, countries such as Australia, Southeast Asian countries, India, Japan, and China are likely to remain afloat. Further in regional segmentation, Orbia Pharma Reports identifies Canada and the US to remain most favorable growth beds.

By the product type, the market is primarily split into

Embolization & coilingNeurothrombectomy Devices

By the application, this report covers the following segments

Treatment of Cerebral AneurysmsTreatment of Cerebral VasospasmVertebroplasty

The following is a brief of some of the most insightful report offerings, vital to deploy appropriate business decisions in global Interventional Neurology Device market to influence market stability and revenue generation.1.Orbis Pharma Reports sketches a thorough analytical demonstration of the global Interventional Neurology Device market, inclusive of versatile details on current market trends and futuristic growth estimations2.The report lends a versatile perspective of market growth influencers that allow in comprehending key market trends harnessing lucrative foothold amidst staggering competition3.The report by Orbis Pharma Reports also ensures a systematic DROT assessment with elaborate references of market manacles and growth initiators besides hovering over ample market opportunities and novel avenues.4.Additional details on overall remunerative value and market competencies have also been minutely identified to ensure stability and sustenance in this unique market research documentation by Orbis Pharma Reports .5.Advanced research and analytical practices such as PORTERs Five Forces analytical methods have been followed to understand trade competencies of buyer and supplier terrains.

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Global Interventional Neurology Device Market 2020 Growth By Manufacturers, Type And Application, Forecast To 2026 : Medtronic, Medikit Co., Ltd.,...

The research describes how SARS-CoV-2 not only invades the respiratory tract but also impacts the central nervous system (CNS), resulting in neurological symptoms such as loss of smell, taste, headache, fatigue and nausea.

It does this by infecting the human brain via nasal mucus, the study has found.

The finding is the first of such to demonstrate how the coronavirus can enter the brain's neurons via the mucosal pathway.

To confirm their hypothesis, Scientists in Germany performed autopsies on 33 patients who died of COVID-19.

READ MORE:Coronavirus can disrupt chemesthesis - and the effects may show up when eating spicy food

The study does not establish how the virus advances to the brain from this point, however.

"Our data suggest that the virus moves from nerve cell to nerve cell in order to reach the brain," explains Dr Helena Radbruch, one of the academics who worked on the study.

"It is likely, however, that the virus is also transported via the blood vessels, as evidence of the virus was also found in the walls of blood vessels in the brain."

The study also detected the presence of immune cells in the cerebral fluid, which were activated following infection.

Professor Heppner said: "In our eyes, the presence of the virus in nerve cells of the olfactory mucosa provides good explanation for the neurologic symptoms found in patients - such as a loss of the sense of smell or taste.

"We also found it in areas of the brain which control vital functions - such as breathing.

According to the NHS, the main symptoms of coronavirus are:

"Most people with coronavirus have at least one of these symptoms," says the health body.

If you have any of the main symptoms of coronavirus, you must get a test to check if you have coronavirus as soon as possible, according to public health advice.

You and anyone you live with should stay at home and not have visitors until you get your test result only leave your home to have a test.

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Coronavirus may enter the brain through the nose - the neurological symptoms to look for - Express

DataIntelo, a prominent market research firm, has published a detailed report on Global Oncology & Neurology Disorder Drugs Market. This market research report provides comprehensive and in-depth analysis on the market which can possibly help an enterprise to identify lucrative opportunities and assist them with fabricating creative business strategies. The market report provides information about the current market scenario regarding the global supply and demand, key market trends and opportunities in the market, and challenges and threats faced by the industry players.

The Oncology & Neurology Disorder Drugs market report talks about the competitive scenario among the industry players and imparts aspiring and emerging industry players with the future market insights in a detailed manner. This market report includes crucial data and figures which are structured out in a concise yet understandable manner. The research report covers the updates on the government regulations and policies which illustrates key opportunities and challenges of the market. DataIntelo has been monitoring the market since few years and collaborated with eminent players of the industry to give better insights on the market. It has conducted vigorous research and implied robust methodology to provide accurate predictions about the market.

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Market Segmentation

Some of the major companies that are covered in the report.

ProStrakanPacira PharmaceuticalsAbbottGlaxoSmithKlineTranscept PharmaceuticalsArchimedes

Note: Additional companies

Based on the type, the market is segmented into

Product Type IProduct Type IIProduct Type III

Based on the application, the market is segregated into

Application IApplication IIApplication III

Based on the geographical location, the market is segregated into

Asia Pacific: China, Japan, India, and Rest of Asia PacificEurope: Germany, the UK, France, and Rest of EuropeNorth America: The US, Mexico, and CanadaLatin America: Brazil and Rest of Latin AmericaMiddle East & Africa: GCC Countries and Rest of Middle East & Africa

DataIntelo provides yearly updates on the Oncology & Neurology Disorder Drugs market that assist the clients to stay ahead in the competitive space.

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This report includes latest product news, advancements, and updates from the prominent player of the industry that has leveraged their position in the market. It also provides business strategies implemented by the key players and yardstick to arrive on informed business decisions. Moreover, it gives insights on the consumer behavior patterns that can help the enterprise to curate the business strategies accordingly.

DataIntelo bestows the clients with the specialized customized options related to the regional analysis, company analysis, and product analysis, among others.

Complete Table Content of the Market

Executive Summary

Assumptions and Acronyms Used

Research Methodology

Oncology & Neurology Disorder Drugs Market Overview

Oncology & Neurology Disorder Drugs Supply Chain Analysis

Oncology & Neurology Disorder Drugs Pricing Analysis

Global Oncology & Neurology Disorder Drugs Market Analysis and Forecast by Type

Global Oncology & Neurology Disorder Drugs Market Analysis and Forecast by Application

Global Oncology & Neurology Disorder Drugs Market Analysis and Forecast by Sales Channel

Global Oncology & Neurology Disorder Drugs Market Analysis and Forecast by Region

North America Oncology & Neurology Disorder Drugs Market Analysis and Forecast

Latin America Oncology & Neurology Disorder Drugs Market Analysis and Forecast

Europe Oncology & Neurology Disorder Drugs Market Analysis and Forecast

Asia Pacific Oncology & Neurology Disorder Drugs Market Analysis and Forecast

Asia Pacific Oncology & Neurology Disorder Drugs Market Size and Volume Forecast by Application

Middle East & Africa Oncology & Neurology Disorder Drugs Market Analysis and Forecast

Competition Landscape

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Impact Of Covid-19 On Oncology & Neurology Disorder Drugs Market Is Slated To Grow Rapidly In The Forthcoming Years With Key Players ProStrakan,...

This article was originally published here

Clin Neurol Neurosurg. 2020 Nov 1:106349. doi: 10.1016/j.clineuro.2020.106349. Online ahead of print.

ABSTRACT

BACKGROUND: Patients with chronic diseases likely develop severe 2019 coronavirus disease (COVID-19). However, little is known about the effects of COVID-19 on patients with neurological disorders. We conducted a systematic review to evaluate the severity of COVID-19 and its effect on neurological symptoms in patients with preexisting neurological disorder and COVID-19.

METHODS: We searched the MEDLINE (PubMed) and medRxiv databases for reports of patients with both preexisting neurological disorders and COVID-19. Studies reporting data on changes in the symptoms of preexisting neurological disorders and/or the severity of COVID-19 were included.

RESULTS: Twenty-six articles with 2278 patients with preexisting neurological disorder and COVID-19 were identified. Of 232 patients, 74 (31.9 %) showed exacerbation of preexisting neurological symptoms of dementia (55/92; 59.5 %), Parkinsons disease (10/17; 58.8 %), epilepsy (1/1; 100 %), and unspecified neurological disorders (8/106; 7.5 %). Of 2168 patients, 478 (22.0 %) showed severe COVID-19 course. These included patients with cerebrovascular disease (86/445; 19.3 %), dementia (70/316; 22.2 %), Parkinsons disease (25/214; 11.7 %), multiple sclerosis (28/71; 39.4 %), spinal cord injury (5/7; 71.4 %), epilepsy (10/98; 10.2 %) and unspecified neurological disorders (254/1011; 25 %).

CONCLUSIONS: Patients with preexisting neurological disorders and COVID-19 may develop exacerbation of neurological symptoms and severe COVID-19. Clinicians should be aware of the risk of symptom exacerbation and severe COVID-19 in patients with preexisting neurological disease and should focus on the prevention and early care of COVID-19.

PMID:33172719 | DOI:10.1016/j.clineuro.2020.106349

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Exacerbation of neurological symptoms and COVID-19 severity in patients with preexisting neurological disorders and COVID-19: A systematic review -...

Transparency Market Research (TMR) has published a new report on the neurovascular embolization devices (neurology) market for the forecast period of 20192027. According to the report, the global neurovascular embolization devices (neurology) market was valued at ~US$ 1.2 Bn in 2018, and is projected to expand at a CAGR of ~3% from 2019 to 2027.

Neurovascular Embolization Devices (Neurology) Market: Overview

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Rise in Prevalence of Stroke to Drive Neurovascular Embolization Devices (Neurology) Market

Embolization Coils Dominated Neurovascular Embolization Devices (Neurology) Market

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Hemorrhagic Stroke Solutions Held Leading Share of Neurovascular Embolization Devices (Neurology) Market

Brain Aneurysms Indication to Lead Neurovascular Embolization Devices (Neurology) Market

Hospitals End User to be Prominent

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North America to Dominate Market; Asia Pacific to Offer Significant Growth Opportunities

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Neurovascular Embolization Devices (Neurology) Market: Web Devices Emerge as Less-invasive Alternative for Neurovascular Embolization Treatment - The...

By: Lifestyle Desk | New Delhi | Updated: November 10, 2020 2:11:57 pmIt is important to keep a track of the symptoms of Parkinson's disease. (Source: Getty Images/Thinkstock)

Parkinsons disease is one of the most common neurological disorders which prevails most in the elderly age group. It is a condition in which a patient holds limited or no control over his movements and body balance. It occurs and progresses with ageing, but in rare cases, it is also witnessed among children and teenagers as well. Also, men are more prone to Parkinsons disease than women, says Dr Rajul Aggrawal, senior consultant, neurologist, Sri Balaji Action Medical Institute, New Delhi who further discusses Parkinsons disease in detail.

As a disease of the central nervous system characterised by difficulty in movements, Parkinsons has four main symptoms, namely tremors, stiffness, postural instabilities, and slowness of movements. Parkinsons disease is a degenerative disease of the brain as a result of which brain neurons are unable to produce dopamine. When dopamine reduces in the brain, it causes the emergence of symptoms of Parkinsons. Parkinsons is a progressive disease though the rate of deterioration may vary in different individuals.

Though causes of Parkinsons are mainly unknown several factors may appear to play a role.

*Genetic Factors: Researchers have identified several genes responsible for Parkinsons but these are rare except in cases where several family members are affected by Parkinsons disease.*Exposure to certain toxins or environmental factors may increase the risk of Parkinsons disease but the risk is relatively less.*Men are 50 per cent more likely to be affected by Parkinsons than women.*Most people develop Parkinsons after 60 years of age. Though 5 to 10 per cent can develop Parkinsons before the age of 50 years. This condition is called early-onset disease which is often but not always inherited.*Parkinsons patients may also experience other symptoms such as difficulty in swallowing, chewing, speaking, urinary problems, constipation, skin problems, depression, emotional changes and sleep disruption. They may occur much before the appearance of cardinal motor symptoms.

ALSO READ | Stan Swamy files plea for straw, sipper in jail; court seeks NIA reply

Early Parkinsons symptoms are subtle and occur gradually. They may be taken as signs of normal ageing, for example, mild tremors, difficulty in getting up from a chair, spending more time in the bathroom, speaking softly, writing becoming small, slow and cramped, lack of facial expressions, stiffness in shoulder joints and knee joints. People also develop a Parkinsons gait that includes a tendency to lean forward, small quick steps as if hurrying forward, reduced swing of arms. They also may have trouble initiating or continuing movements.Usually, Parkinsons starts on one side of the body, in either upper or lower limb and gradually progresses to the other limbs.Currently, no blood laboratory or radiological tests are available to diagnose Parkinsons disease. It is a clinical diagnosis based on history and examination findings. Neurologists may do certain tasks to rule out secondary causes of Parkinsons.

Parkinsons-like symptoms may be found in other degenerative diseases and neurologists would be able to differentiate these from Parkinsons disease.Parkinsons patients should be more cautious about their disease, mentioned Dr Aggarwal.

*Take medicines regularly and manage other daily tasks accordingly.*Never hesitate to seek others help and cooperation in need.*Keep sharing about your situation with loved ones and ask for help or suggestions to get certain work done if they are not available. Do not to hesitate and feel low about your condition.

*Generally our senior citizens need extra care in this regard. Keep a check on the development of the physical symptoms and seek doctors suggestion. Take good care of elderly family members.*Never miss any prescribed medicine suggested by the doctor. Patients may also be on therapies, hence go for them at scheduled times.*Keep a positive outlook toward life and manage daily tasks accordingly. Most of all, refrain from taking stress as it is only going to add to the problems.*Stay away from habits like smoking, alcohol intake, etc.*Lead a healthy lifestyle, keep the nutrition value high, and go for timely check-ups.

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Parkinsons disease: Everything you need to know about the neurological disorder - The Indian Express

Overview Of Interventional Neurology Device Industry 2020-2025:

This has brought along several changes in This report also covers the impact of COVID-19 on the global market.

The Interventional Neurology Device Market analysis summary by Reports Insights is a thorough study of the current trends leading to this vertical trend in various regions. Research summarizes important details related to market share, market size, applications, statistics and sales. In addition, this study emphasizes thorough competition analysis on market prospects, especially growth strategies that market experts claim.

Interventional Neurology Device Market competition by top manufacturers as follow:MedtronicJohnson and JohnsonTerumo CorporationPenumbra, Inc.Merit Medical Systems, IncW.L. Gore & AssociatesMicroport Scientific CorporationMedikit Co., Ltd.Stryker

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The global Interventional Neurology Device market has been segmented on the basis of technology, product type, application, distribution channel, end-user, and industry vertical, along with the geography, delivering valuable insights.

The Type Coverage in the Market are: Embolization & coilingNeurothrombectomy Devices

Market Segment by Applications, covers:Treatment of Cerebral AneurysmsTreatment of Cerebral VasospasmVertebroplasty

Market segment by Regions/Countries, this report coversNorth AmericaEuropeChinaRest of Asia PacificCentral & South AmericaMiddle East & Africa

Major factors covered in the report:

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Market share assessments for the regional and country level segments. Market share analysis of the top industry players. Strategic recommendations for the new entrants. Market forecasts for a minimum of 9 years of all the mentioned segments, sub segments and the regional markets. Market Trends (Drivers, Constraints, Opportunities, Threats, Challenges, Investment Opportunities, and recommendations). Strategic recommendations in key business segments based on the market estimations. Competitive landscaping mapping the key common trends. Company profiling with detailed strategies, financials, and recent developments. Supply chain trends mapping the latest technological advancements.

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Interventional Neurology Device Market: Technological Advancement & Growth Analysis with Forecast to 2025 - Eurowire

Researchers at The Ohio State University Wexner Medical Center have discovered a new immune cell that not only protects the brain and spine from further damage but also encourages nerve cells to regrow, which is unprecedented. Credit: Courtesy of the Wexner Medical Center at Ohio State

Researchers at Ohio State and the University of Michigan discovered a new immune cell that may hold the key to treating incurable neurological diseases such as multiple sclerosis, traumatic brain and spine injuries, and strokes.

The cell releases a substance that stimulates nerve cell growth and allows damaged nerve fiber to regenerate while many other immune cells remove damaged cells Dr. Andrew Sas, an assistant professor of neurology at Ohio State, said. Researchers found the cell after discovering a similar cell in a mouse model.

Sas said this unique ability to save dying nerve cells and grow new ones is important for patients who have difficulty speaking, moving, seeing, feeling and even thinking due to these diseases and injuries.

They are quality of life things, because if you cant use an arm or a leg or you cant talk to others, then you can imagine how much more difficult that life is then compared to all the things that you can do and we take for granted, Sas said. Unfortunately, patients who have neurologic injuries live with a lifetime of disability.

In 2014, there were about 2.5 million traumatic brain injury-related emergency department visits and 56,800 deaths in the U.S. more than 810,000 of the visits and 2,500 of the deaths were children, according to the Centers for Disease Control and Prevention. Neurological diseases also burden many nearly one million people are estimated to have multiple sclerosis in the U.S., according to the National Multiple Sclerosis Society, and about 5,000 people in the U.S. are diagnosed with ALS each year, according to the CDC.

The newly discovered cell is a type of white blood cell called a granulocyte. Dr. Benjamin Segal, professor and chair of the Department of Neurology and director of Ohio States Neuroscience Research Institute, said it resembles an immature neutrophil a plentiful white blood cell in our bloodstream that normally helps fight off infection but is unique.

This is an unusual, neutrophil-like cell. It has features of a more immature stage, but hasnt been described before, Segal said. It expresses certain genes and molecules on its surface that are not normally associated with neutrophils or granulocytes. But some of the markers that they express had been associated with healing processes.

Sas said when researchers injected these cells into mice, they protected damaged nerve cells and enabled nerve fiber growth. In order to see these effects, Sas said an antibody is used to block mature neutrophil cells already present that can stunt the recovery process, allowing a greater production of this new cell.

One of the things that was really important about our discovery is that by blocking mature neutrophils, we actually can enrich this immature population and make it more prevalent so that it has a bigger impact, Sas said. This way, we were able to get more of those cells so that they could have a better, more beneficial response.

Segal said the researchers next step is to identify the cell in people with traumatic brain injuries and manipulate the cell in the same way as in the mouse model.

Sas said they hope to inject the cells into human patients and see the same effects, potentially paving the way for new treatment options.

Its exciting that we have a new line of research and possible therapies that could be coming down the line in the future, that could help [patients] because today, we dont have a lot of therapies, Sas said. Were on the right path to, hopefully, giving patients in the future hope that theyre gonna do better than the patients before them.

Study findings were published Monday in Nature Immunology. The research was funded by the National Eye Institute, National Institutes of Health, the Wings of Life Foundation and the Dr. Miriam and Sheldon G. Adelson Medical Research Foundation, according to a press release.

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New cell may be solution to treating incurable neurological diseases - OSU - The Lantern

A team of UB researchers has published a paper in Nature Communications that is helping to define the best time to give a specific treatment to infants born with Krabbe disease (KD). This treatment has been found to prolong life for these infants for as long as a few years.

The paper was published online in Nature Communication Oct. 23.

Daesung Shin, assistant professor in the Department of Biotechnical and Clinical Laboratory Sciences and the Neuroscience Program, both in the Jacobs School of Medicine and Biomedical Sciences at UB, is the lead investigator. He also conducts research at UBs Hunter James Kelly Research Institute.

KD is an inherited disorder that destroys myelin, the protective coating of nerve cells in the brain and throughout the nervous system. In most cases, signs and symptoms of Krabbe disease develop in babies before 6 months of age, and the disease usually results in death by age 2. When it develops in older children and adults, the course of the disease can vary greatly.

The progressive neurologic disorder is caused by a deficiency of galactosylceramidase (GALC). GALC is an enzyme that breaks down galactosylceramide, an important component of myelin, which ensures the rapid transmission of nerve impulses.

Although there is no cure for KD, hematopoietic stem cell therapy (HSCT), a therapy that makes blood cells, reduces neurologic deterioration and improves developmental advances. These benefits are dependent on the severity of the disease at the time the stem cells are transplanted, and are only beneficial if delivered at a clinically defined pre-symptomatic time point before symptoms appear.

Even though it is widely accepted that early treatment is essential for the most positive outcome, the precise therapeutic window for treatment and what happens during this early time have never been elucidated, Shin says.

To address that issue, his team used mutations to create a novel mouse model of KD.

We engineered an inducible knockout mouse for the GALC gene deletion in specific cells at specific times, which provided us with the opportunity to directly ask when and where GALC enzyme is required for brain development, Shin explains.

We were particularly interested in the role of early developmental GALC function, he says. Our study not only revealed a key developmental process that requires GALC in the perinatal period, but also demonstrated that temporal GALC expression is likely a major contributor to brainstem development.

The researchers found that by increasing GALC levels at or before this newly defined perinatal period they could improve the effectiveness of therapeutic interventions for KD.

For the first time, our work showed the mechanistic evidence to explain why treatment must occur so early, with the defined critical postnatal period at days 4-6 in mice, and demonstrated that temporal GALC expression during this time is a major contributor to brainstem development, Shin says. Augmenting GALC levels at or prior to this newly defined period would likely improve the efficacy of therapeutic interventions for Krabbe patients.

While the time scale between mice and humans is considerably different, the sequence of key events in brain maturation between the two is consistent, he notes. It was estimated that the mouse nervous system at postnatal days 4-6 corresponds to a gestational age of 32 weeks in humans. Therefore, we anticipate that if our result is correct, then in utero treatments at, or prior to, 32 weeks should have better outcomes than conventional postnatal treatment for Krabbe babies.

Shin says his team will further identify which cell type needs to be targeted with therapy.

This work will directly impact the design of novel treatment options for KD patients, he says, noting that KD studies are at the basis of research on other, more common neurodegenerative diseases, such as multiple sclerosis and Parkinsons disease. Therefore, the teams work will have implications beyond KD.

Co-authors on the research were Nadav I. Weinstock, MD-PhD student, and Conlan Kreher, former masters student, both of the HJKRI and the Department of Biochemistry in the Jacobs School; Jacob Favret, research technician in the Department of Biotechnical and Clinical Laboratory Sciences; Lawrence Wrabetz and M. Laura Feltri, both co-directors of the HJKRI and members of the departments of Biochemistry and Neurology, as well as the Neuroscience Program.

Duc Nguyen and Ernesto R. Bongarzone of the Department of Anatomy and Cell Biology in the College of Medicine at the University of Illinois at Chicago also participated in the research.

The project was initiated with the support from Empire State development fund for HJKRI, and further developed and finalized by the R01, R56 and R03 grants from National Institutes for Health-National Institute for Neurological Disorders and Stroke awarded to Shin.

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UB researcher narrows time window for administering specific treatment to infants with Krabbe disease - UB Now: News and views for UB faculty and...

Low dose ketamine infusion may be a safe and tolerable treatment strategy for multiple sclerosis (MS)-related fatigue, according to study results published in Multiple Sclerosis Journal.

Chronic fatigue is a very common and disabling symptom of MS, but the pathophysiological mechanisms are poorly understood and there are no effective medications approved by the U.S. Food and Drug Administration for the treatment of MS-related fatigue. The objective of the current study was to assess the safety, tolerability, and efficacy of low-dose ketamine infusion for the treatment of MS-related fatigue.

This double-blind, randomized, active-placebo-controlled study included 18 patients with MS, recruited between February and August 2019 through advertisements and physician referrals from the Johns Hopkins Multiple Sclerosis Center. Participants were between 18 and 65 years old and were randomized to a ketamine (12 patients) or midazolam (6 patients) infusion. The primary study outcome was change in Daily Fatigue Severity for 7 days following a single intravenous infusion of low-dose ketamine (0.5 mg/kg) or midazolam (0.05 mg/kg).

There was no change in Daily Fatigue Severity score during the first 7 days following infusion (-0.10 points; 95% CI, -0.32 to 0.12; P =.40). Additionally, there was no difference between the ketamine and midazolam groups regarding the trajectory of this score during the first 7 days following infusion (P =.40), indicating that low-dose ketamine infusion did not show statistically significant improvement in fatigue severity.

However, when MS-related fatigue was assessed using Fatigue Severity Scale, there was a trend in reduced Fatigue Severity Scale score at 1 week (-5.2 points; 95% CI, -10.4 to 0.14; P =.06). Furthermore, there was a clinically and statistically significant reduction in Modified Fatigue Impact Scale score at day 28 (-13.5 points; 95% CI, -25.0 to -1.98; P =.04).

The study had several limitations, including the pilot nature, relatively small sample size, negative results on the primary outcome, and the use of the Daily Fatigue Score, which was not a validated tool for MS fatigue research, as the primary outcome.

The study researchers concluded that although the primary outcome of this study was negative, because ketamine infusion was associated with large, clinically significant and long-lasting changes in well-validated and multidimensional fatigue measures, we think these results can be the basis for performing a larger study of ketamine or other glutamate modulating agents for MS-related fatigue.

Reference

Fitzgerald KC, Morris B, Soroosh A, et al. Pilot randomized active-placebo-controlled trial of low-dose ketamine for the treatment of multiple sclerosisrelated fatigue. Mult Scler. Published online July 7, 2020. doi:10.1177/1352458520936226

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The Role of Ketamine Infusion for Patients with MS-Related Fatigue - Neurology Advisor

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Int J Infect Dis. 2020 Oct 27:S1201-9712(20)32247-5. doi: 10.1016/j.ijid.2020.10.044. Online ahead of print.

ABSTRACT

OBJECTIVES: To analyze the cerebrospinal fluid (CSF) of patients with SARS-CoV-2 infection and neurological manifestations to provide evidence for the understanding of mechanisms associated with central nervous system (CNS) involvement in COVID-19.

METHODS: Patients (n = 58) were grouped according to their main neurological presentation: headache (n = 14); encephalopathy (n = 24); inflammatory neurological diseases, including meningoencephalitis (n = 4), acute myelitis (n = 3), meningitis (n = 2), acute disseminated encephalomyelitis (ADEM) (n = 2), encephalitis (n = 2), and neuromyelitis optica (n = 1); and Guillain-Barr syndrome (n = 6). Data about age, sex, cerebrovascular disease, and intracranial pressure were evaluated in combination with CSF profiles defined by cell counts, total protein and glucose levels, concentration of total Tau and neurofilament light chain (NfL) proteins, oligoclonal band patterns, and detection of SARS-CoV-2 RNA.

RESULTS: CSF of patients with inflammatory neurological diseases was characterized by pleocytosis and elevated total protein and NfL levels. Patients with encephalopathy were mostly older men (mean age of 61.0 17.6 years) with evidence of cerebrovascular disease. SARS-CoV-2 RNA in CSF was detected in 2 of 58 cases: a patient with refractory headache, and another who developed ADEM four days after COVID-19 symptoms onset. Three patients presented intrathecal IgG synthesis, and four had identical oligoclonal bands in CSF and serum, indicating systemic inflammation.

CONCLUSION: Patients with neurological manifestations associated with COVID-19 had diverse CSF profiles, even within the same clinical condition. Our findings indicate a possible contribution of viral replication on triggering CNS infiltration by immune cells and the inflammation promoting neuronal injury.

PMID:33127503 | DOI:10.1016/j.ijid.2020.10.044

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Cerebrospinal fluid findings in neurological diseases associated with COVID-19 and insights into mechanisms of disease development - DocWire News

Introduction and COVID-19 Impact AnalysisGlobal Neurology Software Market report is an easy and convenient information hub to obtain access to highly discernable market related developments across domains and verticals, geographical growth spots as well as technological milestones and product-based segmentation that collectively initiate eventful developments in Global Neurology Software Market.

Our versatile teams of in-house research experts and professionals have laid out elaborate deductions about the growth trajectory of the Global Neurology Software Market on the basis of dedicated research initiatives, adhering to international research standards such as PESTEL and SWOT analysis.

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Expert research opinion by our in-house research teams also opine after stringent primary and secondary research endeavors that the Global Neurology Software Market has demonstrated lush growth and revenue stability in past years, and is thus likely to further continue with the trends in the upcoming years. This suggests that the Global Neurology Software Market, despite significant market dents owing to unprecedented COVID-19 outrage is anticipated to recover at optimistic CAGR percentage.

The Major Players Covered in Global Neurology Software Market are:The major players covered in Neurology Software are: Epic, Brainlab, healthfusion, Athenahealth, Practice Fusion, Nextgen, Bizmatics, Greenway Health, Allscripts, Kareo, Advanced Data Systems, NueMD, etc.

Global Neurology Software Market by Type:By Type, Neurology Software market has been segmented into Advanced Neurology EMR Software, Other, etc.

Global Neurology Software Market by Application:By Application, Neurology Software has been segmented into Hospitals, College & Research Institutes, Other, etc.

Market segment by Regions/Countries, this report covers

United StatesEuropeChinaJapanSoutheast AsiaIndiaCentral & South America

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Gauging through Segmentation: Global Neurology Software Market

Key Takeaways from the Report

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The concluding sections of the report analyzing nitty gritty of Global Neurology Software Market evaluates the market in terms of end-use applicability and scope of applications of the range of products that align with the needs of end-user needs and expectations. These vivid information about the minutest details of the Global Neurology Software Market is in place to induce logical business discretion.

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Neurology Software Market Is Expected To Reach Multimillion Usd By The End Of 2025 With a Healthy Cagr Rate: Neurology Software are: Epic, Brainlab,...

This report also researches and evaluates the impact of Covid-19 outbreak on the Oilseed Rape Seed industry, involving potential opportunity and challenges, drivers and risks. We present the impact assessment of Covid-19 effects on Oilseed Rape Seed and market growth forecast based on different scenario (optimistic, pessimistic, very optimistic, most likely etc.).

Global Oilseed Rape Seed Market Overview:

The research report, titled [Global Oilseed Rape Seed Market 2020 by Company, Regions, Type and Application, Forecast to 2025], presents a detailed analysis of the drivers and restraints impacting the overall market. Analysts have studied the key trends defining the trajectory of the market. The research report also includes an assessment of the achievements made by the players in the global Oilseed Rape Seed market so far. It also notes the key trends in the market that are likely to be lucrative. The research report aims to provide an unbiased and a comprehensive outlook of the global Oilseed Rape Seed market to the readers.

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Global Oilseed Rape Seed Market: Segmentation

For clearer understanding of the global Oilseed Rape Seed market, analysts have segmented the market. The segmentation has been done on the basis of application, technology, and users. Each segment has been further explained with the help of graphs figures. This breakdown of the market gives the readers an objective view of the global Oilseed Rape Seed market, which is essential to make sound investments.

Segment by Type, the Interventional Neurology Device market is segmented intoEmbolization & coilingNeurothrombectomy Devices

Segment by Application, the Interventional Neurology Device market is segmented intoTreatment of Cerebral AneurysmsTreatment of Cerebral VasospasmVertebroplasty

Regional and Country-level AnalysisThe Interventional Neurology Device market is analysed and market size information is provided by regions (countries).The key regions covered in the Interventional Neurology Device market report are North America, Europe, Asia Pacific, Latin America, Middle East and Africa. It also covers key regions (countries), viz, U.S., Canada, Germany, France, U.K., Italy, Russia, China, Japan, South Korea, India, Australia, Taiwan, Indonesia, Thailand, Malaysia, Philippines, Vietnam, Mexico, Brazil, Turkey, Saudi Arabia, U.A.E, etc.The report includes country-wise and region-wise market size for the period 2015-2026. It also includes market size and forecast by Type, and by Application segment in terms of sales and revenue for the period 2015-2026.

To understand the changing political scenario, analysts have regionally segmented the market. This gives an overview of the political and socio-economic status of the regions that is expected to impact the market dynamic.

Global Oilseed Rape Seed Market: Research Methodology

To begin with, the analysis has been put together using primary and secondary research methodologies. The information has been authenticated by market expert through valuable commentary. Research analysts have also conducted exhaustive interviews with market-relevant questions to collate this research report.

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Global Oilseed Rape Seed Market: Competitive Rivalry

The research report also studied the key players operating in the global Oilseed Rape Seed market. It has evaluated and elucidated the research and development statuses of these companies, their financial outlooks, and their expansion plans for the forecast period. In addition, the research report also includes the list of strategic initiatives that clearly explain the achievements of the companies in the recent past.

Competitive Landscape and Interventional Neurology Device Market Share AnalysisInterventional Neurology Device market competitive landscape provides details and data information by players. The report offers comprehensive analysis and accurate statistics on revenue by the player for the period 2015-2020. It also offers detailed analysis supported by reliable statistics on revenue (global and regional level) by players for the period 2015-2020. Details included are company description, major business, company total revenue and the sales, revenue generated in Interventional Neurology Device business, the date to enter into the Interventional Neurology Device market, Interventional Neurology Device product introduction, recent developments, etc.The major vendors covered:MedtronicJohnson and JohnsonTerumo CorporationPenumbra, Inc.Merit Medical Systems, IncW.L. Gore & AssociatesMicroport Scientific CorporationMedikit Co., Ltd.Stryker

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Strategic Points Covered in TOC:

Chapter 1: Introduction, market driving force product scope, market risk, market overview, and market opportunities of the global Oilseed Rape Seed market

Chapter 2: Evaluating the leading manufacturers of the global Oilseed Rape Seed market which consists of its revenue, sales, and price of the products

Chapter 3: Displaying the competitive nature among key manufacturers, with market share, revenue, and sales

Chapter 4: Presenting global Oilseed Rape Seed market by regions, market share and with revenue and sales for the projected period

Chapter 5, 6, 7, 8 and 9: To evaluate the market by segments, by countries and by manufacturers with revenue share and sales by key countries in these various regions

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Oilseed Rape Seed Market: Information, Figures and Analytical Insights 2020-2025 - PRnews Leader

The Society of Vascular and Interventional Neurology together with MT2020 will distribute a report detailing their global initiative to reduce death and disability in stroke patients

MIAMI, Oct. 29, 2020 /PRNewswire/ --Mission Thrombectomy 2020+ (MT2020+), a global campaign of SVIN (Society of Vascular and Interventional Neurology), has just published "Mechanical Thrombectomy for Acute Stroke. Building Thrombectomy Systems of Care in Your Region: Why and How," a White Paper targeted towards health policymakers. The paper examines the widespread inaccessibility and geographical disparities in receiving Mechanical Thrombectomy (MT), an interventional treatment that has been proven to have overwhelming benefit for a common type of disabling stroke in multiple large studies across many countries since 2015. MT needs to be performed within the first 24 hours of the onset of stroke symptoms for disabling stroke from a large artery being suddenly blocked in the brain (commonly called LVO stroke), and its outcomes are highly time-sensitive, especially early on. The White Paper report calls for sweeping increase in MT awareness, accessibility, and action on a worldwide level. It will be distributed on Oct. 29to coincide with World Stroke Day.

Currently, the United States is a global leader in MT patient care, but the burden of care is almost 4-5 times greater in many lower to middle income countries. According to MT2020, the data on stroke patients and the level of care they receive are as follows.

"Large vessel occlusion stroke is a long-standing silent global crisis that now has a highly effective solutionsince the last fiveyears: Mechanical Thrombectomy. However, thrombectomy care isn't widely accessible with colossal geographic disparities on a global level," said Dr. Dileep Yavagal, MT2020 Chair and GEC Co-Chair and Past-President of SVIN. "We are calling on public health policymakers to increase physical, financial and diagnostic access to thrombectomy for patients with disabling stroke to prevent a lifetime of suffering and death."

The White Paper also provides perspective on:

The White paper will be disseminated in all six continents by the 82 Regional Committees of MT2020. The long-term goal is the emergence and wide-spread availability of Mechanical Thrombectomy as the standard of care globally. While progress has been made since the formation of MT2020 in 2016, there is still an imminent need for continued efforts.

About Mission Thrombectomy 2020 (MT2020)

Mission Thrombectomy 2020+ is a global health campaign, founded by the Society of Vascular and Interventional Neurology (SVIN) in 2016, to accelerate access to the stroke thrombectomy surgery globally. The goal of MT2020 is to coalesce global public health efforts with a goal to double access to thrombectomy every two years for stroke caused by large vessel occlusion (LVO). The campaign will improve stroke care worldwide by increasing the rate of stroke thrombectomy for eligible patients from less than 100,000 procedures today to 202,000 annually by end of 2020 and thereby reduce global stroke disability. Stroke Thrombectomy, also known as Mechanical Thrombectomy, is the new highly effective standard of care that reverses paralysis from a stroke in over 60% of patients if done by experts within sixhours of stroke symptoms. For further information about MT2020, please visit http://missionthrombectomy2020.org.

About SVIN

The Society of Vascular and Interventional Neurology was created to achieve the highest level of care for patients through increased collaboration in scientific research and by educating young professionals and training young investigators. The Society also aims to provide opportunities to connect leaders in the field and provide a common ground for dialogue and creation of practice and safety standards. Our mission is to represent the advancement of interventional neurology as a field with the ultimate goal of improving clinical care and outcomes in patients with stroke and cerebrovascular diseases. For further information about SVIN, please visit http://www.svin.orgor find us on Facebook, Twitter, or LinkedIn.

For more information about MT2020, contact Dileep Yavagal at [emailprotected].

Related Links

Society of Vascular and Interventional Neurology

Mission Thrombectomy

http://www.svin.org

SOURCE Society of Vascular and Interventional Neurology

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A Global Push to Increase Awareness, Action and Access to Thrombectomy Care for Stroke Patients is Underway - PR Newswire India

250 Pages Rare Neurological Disease Treatment Market Survey by Fact MR, A Leading Business and Competitive Intelligence Provider

According to Fact MRs recent market research,sales of Rare Neurological Disease Treatmentto swell at propelled CAGR through2031, as investment towards expansion of healthcare infrastructure continues rising. The goal of the survey is uncover growth opportunities, key trends, growth drivers, and challenges. It also provides recommendations to assist businesses in preparing for unforeseen challenges.

Focus on improving overall patient care will remain a chief growth driver. Besides this, Rare Neurological Disease Treatment market will continue gaining from increasing willingness among patients and families to spend on advanced healthcare.

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Healthcare organizations around the world are deploying digital tools to accommodating changing consumer preferences. They are pressing on solving the long-standing challenge pertaining to care model innovation.

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Country-specific assessment on demand for rare neurological disease treatment has been provided for each regional market, along with the market size valuation and forecast price point assessment, price index and impact analysis of key regional and country-wise dynamics, which were obtained through quotes from numerous rare neurological disease treatment manufacturers, experts, and suppliers.

Y-o-Y growth projections have also been offered on all regional markets incorporated in the report. Moreover, future trends, growth prospects, and other possibilities related to the market have been answered in the report.

The report provides company-level market share analysis, which has been derived on the basis of the companys annual sales and segmental revenue in all the target disease indications. The market has been forecasted based on constant currency rates.

The report provides detailed competitive and company profiles of key participants operating in the global rare neurological disease treatment market.

Some of the key competitors operating in the rare neurological disease treatment market are Novartis AG, Pfizer, Inc., Johnson & Johnson Services, Inc. Bayer AG, GlaxoSmithKline Plc, Sanofi S.A., Allergan Plc, Merck & Co., Inc., and others.

The following report provides forecast and analysis of the global rare neurological disease treatment market along with the historical data of 2013, estimated data 2018 and forecast data up to 2028 in terms of value (US$ Mn), according to a Fact.MR study.

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To provide users of this report with a comprehensive view of the market, we have included a detailed competitive analysis about the key players involved in the market and strategic overviews.

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Strategic partnerships between pharmaceutical giants and researchers as well as orphan drug legislations are providing financial incentives for companies developing drugs for rare neurological diseases, Says an Analyst at Fact.MR

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The post Shift towards Orphan Drugs is Anticipated to Drive Demand Growth in Rare Neurological Disease Treatment Market appeared first on Latest Market Reports.

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Shift towards Orphan Drugs is Anticipated to Drive Demand Growth in Rare Neurological Disease Treatm - PharmiWeb.com

LYON, France, December 06, 2021--(BUSINESS WIRE)--POXEL SA (Euronext POXEL - FR0012432516), a clinical stage biopharmaceutical company developing innovative treatments for chronic diseases with metabolic pathophysiology, including non-alcoholic steatohepatitis (NASH) and rare disorders, today announced the formation of its Scientific Advisory Board (SAB) for rare metabolic diseases. The new SAB will initially focus on supporting Poxel's X-linked adrenoleukodystrophy (ALD) program.

"I am delighted to welcome this distinguished group of scientific thought leaders to Poxels SAB for rare metabolic diseases. These therapeutic indications, including ALD, are areas of unsurpassed unmet medical need where treatments are not available or very limited. We are grateful for their informed counsel and deep knowledge and experience that will help shape Poxels discovery and clinical-stage programs and further advance our mission to develop therapies for rare metabolic diseases. We look forward to continuing to collaborate with this accomplished group of advisors as we expand our clinical programs, and initiate Phase 2a studies for ALD in early 2022, with both PXL065, a novel deuterium modified thiazolidinedione and PXL770, a first-in-class direct AMPK activator," said David E. Moller, Poxel's Chief Scientific Officer.

Poxel recently hosted its first SAB meeting on rare diseases, which led to highly productive discussions regarding the potential of its compounds and the future of its programs in ALD, including the design of its two proof-of-concept (POC) Phase 2a studies which the Company intends to initiate early 2022.

The members of the Rare Metabolic Diseases Scientific Advisory Board are the following:

Prof. Florian Eichler, MD, is an expert in inherited diseases with metabolic pathophysiology that affect the nervous system. Dr. Eichler received training in pediatric neurology and neurogenetics at Harvard and Johns Hopkins. He is currently the director of the Center for Rare Neurologic Disorders and the director of the Leukodystrophy Service at Massachusetts General Hospital (MGH), Harvard Medical School, US. His research focus is on the genetics of peroxisomal disorders, lipid metabolism, and gene therapy for neurodegenerative diseases. Dr. Eichler is also President of ALD Connect.

Story continues

Prof. Marc Engelen, MD, PhD, is a clinical researcher, a specialist in pediatric neurology, gastroenterology and endocrinology, and an expert in peroxisomal disorders and leukodystrophies at Amsterdam University Medical Centers, Netherlands. Dr. Engelen received his MD and PhD degrees at the University of Amsterdam. Along with Stephan Kemp and other members of his team, Dr. Engelen's research efforts have unveiled novel approaches to detecting, diagnosing and monitoring neurometabolic diseases including ALD.

Prof. S. Ali Fatemi, MD, is a physician-scientist leader in pediatric neurology and neurometabolic diseases. Dr. Fatemi was trained at the Medical University of Vienna, Austria and at Kennedy Krieger Institute, Johns Hopkins, US. He founded the Moser Center for Leukodystrophies and is now Chief Medical Officer at the Kennedy Krieger Institute, Baltimore, US. His research is focused on basic and translational studies pertaining to the pathophysiology of ALD.

Prof. Stephan Kemp, PhD, is a translational research expert in genetic neurometabolic diseases. He was trained at Johns Hopkins University, Kennedy Krieger Institute, and at the University of Amsterdam, where he is a longstanding faculty member. His research focuses on lipid metabolism and neurotoxicity and he has published many seminal papers on the pathobiology of ALD. He also leads efforts focused on newborn screening for rare metabolic disorders in the Netherlands.

Prof. Fanny Mochel, MD, PhD, is an expert in inborn errors of metabolism. She received training in genetics and neuroscience at University Pierre and Marie Curie in Paris and she is a faculty member in genetics at this university. Dr. Mochel also leads the French reference Center on Neurometabolic diseases and is co-chair of the French society for inborn of errors of metabolism and a council member of the Society for the Study of Inborn Errors of Metabolism. Her research efforts include characterization and treatment of brain energy deficiencies in neurometabolic disease, the identification of novel biomarkers, metabolomics and in vivo metabolic imaging, as well as therapeutic approaches targeting the Krebs cycle.

Dr. Jaspreet Singh, PhD, is a neuroscientist researcher focusing on ALD pathophysiology, neuroinflammation, biomarker development and testing novel therapeutic options. He was trained in India and at the Medical University of South Carolina, US. He is currently a faculty member in the Department of Neurology at the Henry Ford Health System in Detroit, US.

Prof. Keith Van Haren, MD, is a pediatric neurologist and an expert in ALD. He received medical and specialty training at the University of Rochester Medical School, Harvard Medical School, and Stanford University, US. Dr. Van Haren is a faculty member in Neurology and Neurological Sciences at Stanford. He cares for patients including many with ALD and also leads a laboratory focusing on the study of single-gene mutations and attendant molecular mechanisms leading to neuroinflammation in humans.

About ALDX-linked adrenoleukodystrophy (ALD) is an orphan neurometabolic disease caused by mutations in the ABCD1 gene which encodes for a key protein that is required for metabolism of very long chain fatty acids (VLCFA) by peroxisomes (cellular organelles). ALD is the most common leukodystrophy with a prevalence similar to hemophilia up to 1/10,000 individuals in the general population have ALD [https://rarediseases.org]. Forms of this disease include cerebral ALD (C-ALD) and adrenomyeloneuropathy (AMN) which is the most common form typically occurring in adolescence through adulthood. AMN is characterized by chronic and progressive distal axonopathy involving the long tracts of the spinal cord and to a lesser extent the peripheral nerves resulting in progressive stiffness and weakness in the legs, impaired gait and balance, incontinence, and loss of sensation. All men are affected, and many women also present with features of AMN with a later onset. C-ALD is characterized by inflammatory demyelination of cells in the brain and typically afflicts children, but many men with AMN may also develop cerebral disease; these white matter brain lesions lead to severe neurologic deficits and death. There are no approved medicines for ALD (other than glucocorticoid supplements for associated adrenal insufficiency). C-ALD when first detected in early childhood, can be treated with hematopoietic stem cell transplantation. HSCT is currently limited to early stage of C-ALD and this procedure is at risk of severe adverse reactions.

About Poxel SA

Poxel is a clinical stage biopharmaceutical company developing innovative treatments for chronic serious diseases with metabolic pathophysiology, including non-alcoholic steatohepatitis (NASH) and rare disorders. Poxel has clinical and earlier-stage programs from its adenosine monophosphate-activated protein kinase (AMPK) activator and deuterated TZD platforms targeting chronic and rare metabolic diseases. For the treatment of NASH, PXL065 (deuterium-stabilized R-pioglitazone) is in a streamlined Phase 2 trial (DESTINY-1). PXL770, a first-in-class direct AMPK activator, has successfully completed a Phase 2a proof-of-concept trial for the treatment of NASH, which met its objectives. For the rare inherited metabolic disorder, adrenoleukodystrophy (ALD), the company intends to initiate Phase 2a proof of concept studies with PXL065 and PXL770 in patients with adrenomyeloneuropathy (AMN). TWYMEEG (Imeglimin), Poxels first-in-class lead product that targets mitochondrial dysfunction, has been approved and launched for the treatment of type 2 diabetes in Japan. Poxel expects to receive sales-based payments and royalties from Sumitomo Dainippon Pharma. Poxel has a strategic partnership with Sumitomo Dainippon Pharma for Imeglimin in Japan, China, South Korea, Taiwan and nine other Southeast Asian countries. The Company intends to generate further growth through strategic partnerships and pipeline development. Listed on Euronext Paris, Poxel is headquartered in Lyon, France, and has subsidiaries in Boston, MA, and Tokyo, Japan.

For more information, please visit: http://www.poxelpharma.com

All statements other than statements of historical fact included in this press release about future events are subject to (i) change without notice and (ii) factors beyond the Companys control. These statements may include, without limitation, any statements preceded by, followed by or including words such as "target," "believe," "expect," "aim," "intend," "may," "anticipate," "estimate," "plan," "project," "will," "can have," "likely," "should," "would," "could" and other words and terms of similar meaning or the negative thereof. Forward-looking statements are subject to inherent risks and uncertainties beyond the Companys control that could cause the Companys actual results or performance to be materially different from the expected results or performance expressed or implied by such forward-looking statements.

View source version on businesswire.com: https://www.businesswire.com/news/home/20211205005012/en/

Contacts

Poxel SA Catherine DavidInvestor Relations & Communication Managercatherine.david@poxelpharma.com +33 7 64 57 61 78

Aurlie BozzaInvestor Relations & Communication Directoraurelie.bozza@poxelpharma.com +33 6 99 81 08 36

Elizabeth WooSenior Vice President, Investor Relations & Communicationelizabeth.woo@poxelpharma.com

Investor relations / Media NewCapEmmanuel Huynh or Arthur Rouillpoxel@newcap.eu +33 1 44 71 94 94

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Poxel Announces the Formation of its Scientific Advisory Board for Rare Metabolic Diseases - Yahoo Finance

Daniel Gibbs had received only four monthly doses of Biogens experimental Alzheimers drug in a clinical trial in 2017 when he ended up in an intensive care unit.He had an excruciating headache, and his blood pressure was so high that doctors thought he might be having a stroke.

It turned out that the retired Portland, Ore., neurologist who had treated Alzheimers patients before he was diagnosed with the disease himself in 2015 was experiencing some of the worst reported side effects of the drug. Doctors prescribed medicines to lower his blood pressure, which reached 206/116, and later to reduce brain swelling. But for weeks afterward, he struggled to read, follow conversations, and do simple math. He recovered but never again took the Alzheimers drug.

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Retired neurologist with Alzheimer's knows firsthand the risks of Aduhelm - STAT - STAT

The latest research report on the Global Neurology Devices Market provides the cumulative study on the COVID-19 outbreak to provide the latest information on the key features of the Neurology Devices market. This intelligence report contains investigations based on current scenarios, historical records and future forecasts. The report contains various market forecasts related to market size, revenue, production, CAGR, consumption, gross margin in the form of charts, graphs, pie charts, tables and more. While emphasizing the main driving and restraining forces in this market, the report also offers a comprehensive study of future trends and developments in the market. It also examines the role of the major market players involved in the industry, including their business overview, financial summary and SWOT analysis. It provides a 360-degree overview of the industries competitive landscape. Neurology Devices Market shows steady growth and CAGR is expected to improve during the forecast period.

The Global Neurology Devices Market Report gives you in-depth information, industry knowledge, market forecast and analysis. The global Neurology Devices industry report also clarifies financial risks and environmental compliance. The Global Neurology Devices Market Report helps industry enthusiasts including investors and decision makers to make reliable capital investments, develop strategies, optimize their business portfolio, succeed in innovation and work safely and sustainably.

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Top Key Players Profiled in this report are:

The report is an assortment of direct information, subjective and quantitative assessment by industry specialists, contributions from industry examiners and Neurology Devices industry members over the worth chain. The report offers a top to bottom investigation of parent market patterns, macroeconomic measures, and control components. Besides, the report likewise overviews the subjective effect of unmistakable market factors on Neurology Devices market sections and geologies.

Neurology Devices Market Segmentation:

Based on Type

Based on Application

Global Neurology Devices Market: Regional Segments

The different section on regional segmentation gives the regional aspects of the worldwide Neurology Devices market. This chapter describes the regulatory structure that is likely to impact the complete market. It highlights the political landscape in the market and predicts its influence on the Neurology Devices market globally.

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The Study Objectives are:

This report includes the estimation of market size for value (million USD) and volume (K Units). Both top-down and bottom-up approaches have been used to estimate and validate the market size of Neurology Devices market, to estimate the size of various other dependent submarkets in the overall market. Key players in the market have been identified through secondary research, and their market shares have been determined through primary and secondary research. All percentage shares, splits, and breakdowns have been determined using secondary sources and verified primary sources.

Some Major Points from Table of Contents:

Chapter 1. Research Methodology & Data Sources

Chapter 2. Executive Summary

Chapter 3. Neurology Devices Market: Industry Analysis

Chapter 4. Neurology Devices Market: Product Insights

Chapter 5. Neurology Devices Market: Application Insights

Chapter 6. Neurology Devices Market: Regional Insights

Chapter 7. Neurology Devices Market: Competitive Landscape

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Global Neurology Devices Market 2021: SWOT Analysis of Key Driving Factors for Growing CAGR Value | Top Brands: Boston Scientific, Terumo Corporation,...