A Basic Introduction to Nanomedicine Market.

The Nanomedicine market report emphasizes on latest data such as driver, emerging trends, and opportunities. This document also covers other important information such as size, restraints, share, challenges, and major players for the forecast period of 2021-2028. The report includes the SWOT analysis of leader companies from the global Nanomedicine market. It also enlists and analyzes the most recent market developments shaping the future of the foremost players and industry.

The report puts a special emphasis on key driving and restraining factors for the market, along with a comprehensive study of the emerging trends and future developments of the market. The report further provides an elaborate study of micro-and macro-economic aspects that are anticipated to influence the demand for the market.

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Major players covered in this report: GE Healthcare, Johnson & Johnson, Mallinckrodt plc, Merck & Co. Inc., Nanosphere Inc., Pfizer Inc., Sigma-Tau Pharmaceuticals Inc., Smith & Nephew PLC, Stryker Corp, Teva Pharmaceutical Industries Ltd., UCB (Union chimique belge) S.A

Following the fundaments, the market is segmented on the basis of geography:

This report studies the top players, focuses on product capacity, production, value, consumption, market share and growth opportunity from this geographies, covering basis of geography: North America (U.S., Canada, Mexico), Europe (U.K., France, Germany, Spain, Italy and Rest of Europe), Asia Pacific (China, Japan, South Korea, ASEAN, India, Rest of Asia Pacific),Latin America (Brazil, Argentina, Colombia, and Rest of L.A.), Middle East and Africa (Turkey, GCC, UAE and South Africa Rest of Middle East).

Results of the recent scientific undertakings towards the development have been studied. Nevertheless, the factors affecting the leading industry players to adopt synthetic sourcing of the market products have also been studied in this statistical surveying report. As per the report, Nanomedicine market revenue in the year 2020 was USD XX million and is expected to reach USD XX million in the year 2028 at XX% CAGR. It describes current changing market trends to help our clients make astute decisions accordingly. We are also ready to serve with a customized report. According to the need of the clients, this report can be customized and available in a separate report for the specific region.

**NOTE:Our analysts monitoring the situation across the globe explains that the market will generate remunerative prospects for producers to post the COVID-19 crisis.

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Secondary Data Sources That We Refer To:

Annual reports, investor presentations, SEC filings, and press releases of companies operating in the market.Website, reports, and press releases of end-user facilities.

Secondary Research Is Conducted To Derive The Following Information:

Details such as revenues, market share, strategies, growth rate, product & their pricing by region/country for all major companiesNumber of procedures and an average price of proceduresReplacement rate and pricing of capital equipmentMarket dynamics in relation to the market under focus Drivers, restraints, trends, and opportunitiesMarket & technological trends, new product developments, product pipeline

COVID-19 Impact on Global Nanomedicine Market

The market report analyses the impact of Coronavirus (COVID-19) on the industry. Since the COVID-19 virus outbreak in December 2020, the disease has spread to almost 180+ countries around the globe with the World Health Organization declaring it a public health emergency.

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Key trends that will shape the future of Nanomedicine Market to 2027 | GE Healthcare, Johnson & Johnson, Mallinckrodt plc The Courier - The...

New Jersey, United States: Market Research Intellect has added a new research report titled, Healthcare Nanotechnology (Nanomedicine) Market Professional Survey Report 2020 to its vast collection of research reports. The Healthcare Nanotechnology (Nanomedicine) market is expected to grow positively for the next five years 2020-2026.

The Healthcare Nanotechnology (Nanomedicine) market report studies past factors that helped the market to grow as well as, the ones hampering the market potential. This report also presents facts on historical data from 2011 to 2019 and forecasts until 2026, which makes it a valuable source of information for all the individuals and industries around the world. This report gives relevant market information in readily accessible documents with clearly presented graphs and statistics. This report also includes views of various industry executives, analysts, consultants, and marketing, sales, and product managers.

Key Players Mentioned in the Healthcare Nanotechnology (Nanomedicine) Market Research Report:

Market Segment as follows:

The global Healthcare Nanotechnology (Nanomedicine) Market report highly focuses on key industry players to identify the potential growth opportunities, along with the increased marketing activities is projected to accelerate market growth throughout the forecast period. Additionally, the market is expected to grow immensely throughout the forecast period owing to some primary factors fuelling the growth of this global market. Finally, the report provides detailed profile and data information analysis of leading Healthcare Nanotechnology (Nanomedicine) company.

Healthcare Nanotechnology (Nanomedicine) Market by Regional Segments:

The chapter on regional segmentation describes the regional aspects of the Healthcare Nanotechnology (Nanomedicine) market. This chapter explains the regulatory framework that is expected to affect the entire market. It illuminates the political scenario of the market and anticipates its impact on the market for Healthcare Nanotechnology (Nanomedicine) .

The Healthcare Nanotechnology (Nanomedicine) Market research presents a study by combining primary as well as secondary research. The report gives insights on the key factors concerned with generating and limiting Healthcare Nanotechnology (Nanomedicine) market growth. Additionally, the report also studies competitive developments, such as mergers and acquisitions, new partnerships, new contracts, and new product developments in the global Healthcare Nanotechnology (Nanomedicine) market. The past trends and future prospects included in this report makes it highly comprehensible for the analysis of the market. Moreover, The latest trends, product portfolio, demographics, geographical segmentation, and regulatory framework of the Healthcare Nanotechnology (Nanomedicine) market have also been included in the study.

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Table of Content

1 Introduction of Healthcare Nanotechnology (Nanomedicine) Market1.1 Overview of the Market1.2 Scope of Report1.3 Assumptions

2 Executive Summary

3 Research Methodology3.1 Data Mining3.2 Validation3.3 Primary Interviews3.4 List of Data Sources

4 Healthcare Nanotechnology (Nanomedicine) Market Outlook4.1 Overview4.2 Market Dynamics4.2.1 Drivers4.2.2 Restraints4.2.3 Opportunities4.3 Porters Five Force Model4.4 Value Chain Analysis

5 Healthcare Nanotechnology (Nanomedicine) Market, By Deployment Model5.1 Overview

6 Healthcare Nanotechnology (Nanomedicine) Market, By Solution6.1 Overview

7 Healthcare Nanotechnology (Nanomedicine) Market, By Vertical7.1 Overview

8 Healthcare Nanotechnology (Nanomedicine) Market, By Geography8.1 Overview8.2 North America8.2.1 U.S.8.2.2 Canada8.2.3 Mexico8.3 Europe8.3.1 Germany8.3.2 U.K.8.3.3 France8.3.4 Rest of Europe8.4 Asia Pacific8.4.1 China8.4.2 Japan8.4.3 India8.4.4 Rest of Asia Pacific8.5 Rest of the World8.5.1 Latin America8.5.2 Middle East

9 Healthcare Nanotechnology (Nanomedicine) Market Competitive Landscape9.1 Overview9.2 Company Market Ranking9.3 Key Development Strategies

10 Company Profiles10.1.1 Overview10.1.2 Financial Performance10.1.3 Product Outlook10.1.4 Key Developments

11 Appendix11.1 Related Research

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Tags: Healthcare Nanotechnology (Nanomedicine) Market Size, Healthcare Nanotechnology (Nanomedicine) Market Growth, Healthcare Nanotechnology (Nanomedicine) Market Forecast, Healthcare Nanotechnology (Nanomedicine) Market Analysis, Healthcare Nanotechnology (Nanomedicine) Market Trends, Healthcare Nanotechnology (Nanomedicine) Market

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Healthcare Nanotechnology (Nanomedicine) Market Size Analysis, Top Manufacturers, Shares, Growth Opportunities and Forecast to 2026 - Science In Me

Researchers in the cancer nanomedicine community debate whether use of nanoparticles can best deliver drug therapy to tumors passively by adding a targeted anti-cancer molecule to bind to specific cancer cell receptor and, in theory, keep the nanoparticle in the tumor longer.

According to a study published in Science Advances, new research on tumors by investigators at the Johns Hopkins Kimmel Cancer Center suggest that the question is more complicated. Laboratory testing of 5 human cancer cell lines with 3 variants of the immune system found that nanoparticles coated with trastuzumab, a drug that targets human epidermal growth factor receptor 2 (HER2)-positive breast cancer cells, were better retained in the tumors than plain nanoparticles, even in tumors that did not express the pro-growth HER2 protein.

However, immune cells of the host exposed to nanoparticles induced an anti-cancer immune response by activating T cells that invaded and slowed tumor growth.

Its been known for a long time that nanoparticles, when injected into the bloodstream, are picked up a scavenger-like macrophages and other immune system cells, said senior study author Robert Ikov, PhD, MSc. Many researchers in the field have been focused on trying to reduce interaction with immune cells, because they have been trying to increase the circulation time of the nanoparticles and their retention in tumor cells. But our study demonstrates that the immune cells in the tumor collect and react to the particles in such a way to stimulate an anti-cancer response. This may hold potential for advancing beyond drug delivery toward developing cancer immunotherapies.

The researchers conducted in vitro experiments by applying some plain starch-coated iron oxide nanoparticles and others coated with trastuzumab to 5 human breast cancer cell lines. They found that the amount of binding between the trastuzumab-coated nanoparticles and cells depended on how much the cancer cells expressed the oncogene HER2. In patients, HER-positive breast cancers are among the most resistant to standard chemotherapy. Trastuzumab (Herceptin, Genentech) targets HER2-postive tumor cells and triggers the immune system as well.

Researchers had previously suspected that animals immune systems were interacting strongly with the nanoparticles and playing a role in determining retention of the particles in the tumor, whether or not a drug was added. Experiments revealed that tumor-associated immune cells were responsible for collecting the nanoparticles and that cell lines with an intact immune system retained more of the trastuzumab-coated nanoparticles than those without.

In addition, inflammatory immune cells in the tumors immediate surroundings seized more of the coated nanoparticles than the plain ones, according to the study. Finally, in a series of 30-day experiments, the researchers found that exposure to nanoparticles inhibited tumor growth 3 to 5 times more than controls, and increased CD8-positive cancer-killing T cells in the tumors.

The anti-cancer immune activating response was equally effective with exposure to either plain or trastuzumab-coated nanoparticles. The investigators said that this demonstrated that systemic exposure to nanoparticles can cause a systemic host immune response that leads to anti-cancer immune stimulation and does not require nanoparticles to be inside the tumors.

The work suggests that complex interdependencies exist between the host and tumor immune responses to nanoparticle exposure. These results offer possibilities for exploring nanoparticle targeting of the tumor immune microenvironment and demonstrate exciting new potential to develop nanoparticles as platforms for cancer immune therapies, according to the study.

The investigators next plan to study whether the same types of immune responses can be generated for noncancer conditions, such as infectious diseases.

Reference

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Study Reveals Nanoparticle Therapy Delivery in Breast Cancer - Pharmacy Times

Elisabeth Bik, the microbiologist and research integrity consultant noted for unearthing evidence of research misconduct, tweeted on February 21that she and some others had uncovered over 400 scientific papers that all share a very similar title layout, graph layout, and (most importantly) the same Western blot layout indicating an organised web of potential fraud. She also expressed concern that there might be hundreds of papers more, and that she and her collaborators may just have spotted the obviously fraudulent ones.

Western blotting is a technique that microbiologists employ to identify the proteins present in a tissue sample. As an analytical technique involving real-world materials, no two images of western blots are supposed to look alike, and similarities suggest the image may have been manipulated, inadvertently or otherwise.

Guided by this and similar giveaways, Bik, @SmutClyde, @mortenoxe and @TigerBB8 (all Twitter handles of unidentified persons), report as written by Bik in ablog post that the Western blot bands in all 400+ papers are all very regularly spaced and have a smooth appearance in the shape of a dumbbell or tadpole, without any of the usual smudges or stains. All bands are placed on similar looking backgrounds, suggesting they were copy-pasted from other sources or computer generated.

Bik also notes that most of the papers, though not all, were published in only six journals: Artificial Cells Nanomedicine and Biotechnology,Journal of Cellular Biochemistry,Biomedicine & Pharmacotherapy,Experimental and Molecular Pathology,Journal of Cellular Physiology, andCellular Physiology and Biochemistry, all maintained reputed publishers and importantly all of them peer-reviewed.

As a result, the discovery of the problem papers has prompted concerns about the ability of peer-review to check research misconduct in the scientific community.

Indeed, when Bik writes, Finding these fabricated images should not rely solely on the work of unpaid volunteers, she evidently means herself and her collaborators but her words also apply to peer-reviewers, who are unpaid for their work and often lack both the resources and the inclination to investigate each paper in close detail. As a result, peer-review is often not the insurmountable defence some proclaim it to be, nor are peer-reviewed journals as free of bogus science as they claim to be.

As Madhusudhan Raman, a postdoctoral scholar at the Tata Institute of Fundamental Research, Mumbai,wrote inThe Wire, any attempt to radically change the nature of peer-review must necessarily be accompanied by a change in the way the referees are compensated for their time and effort, especially within academia.

A PubPeer user who goes by Indigofera Tanganyikensis first identified the problem in two papers (thisandthis) both published by Chinese researchers. On February 17 this year, a little under a week before Bik published her blog post, two American researchers Jennifer A. Byrne and Jana Christopher published an articlediscussing similar research misconduct based on 17 papers they had discovered.

According to Bik, As it turns out, Byrne and Christophers publication describes the exact same set of papers that our small team of image forensics detectives had been working on in the past month.

These sleuths, as @SmutClydewrote on Leonid Schneiders blog, believe they have stumbled upon at least one paper mill. To quote (selectively) from Biks post,

A paper mill is a shady company that produces scientific papers on demand. They sell these papers to [people] who do not have any time in their educational program to actually do research. Authorships on ready-to-submit or already-accepted papers are sold to medical students for hefty amounts. Whether or not the experiments described in these papers has actually been performed is not clear. Some of these paper mills might have laboratories producing actual images or results, but such images might be sold to multiple authors to represent different experiments. Thus, the data included in these papers is often falsified or fabricated.

The mills seem to have been hired by Chinese clinicians affiliated to various medical colleges and hospitals in China (234 of the 400+ papers have been authored by people affiliated to institutions in Shandong province). The papers were all published between 2016 and 2020. @SmutClyde wrote that after they publicised their findings, including thedataset of papers they had identified as potentially fraudulent (and which they continue to update), an author of one of the papers wrote in:

Being as low as grains of dust of the world, countless junior doctors, including those younger [than] me, look down upon the act of faking papers. But the system in China is just like that, you cant really fight against it. Without papers, you dont get promotion; without a promotion, you can hardly feed your family. I also want to have some time to do scientific research, but its impossible. During the day, I have outpatient surgeries; after work, I have to take care of my kids. I have only a little bit time to myself after 10 pm, but this is far from being enough because scientific research demands big trunks of time. The current environment in China is like that.

Considering how the peer-review of all of those journals have failed, what the detectives have found effectively represents a large volume of unscientific data entering the scientific literature, funnelled predominantly by Chinese researchers who probably hired a paper mill to help meet the publishing requirements set by their respective institutions. Bik wrote that it is of great concern to see that this specific paper mill has successfully infected particular journals and that it is very alarming to see that journal editors do not appear to have noticed the similarities between dozens of papers published in their journals.

This said, the note from the unnamed Chinese author indicates the source of the problem is hardly new or even confined to China.

For example, until Prakash Javadekar, then the Union human resource development minister, said in mid-2017 that college teachers would not be required to undertake research to qualify for promotions, people who had not trained for research and have since been embedded in environments not properly equipped to support research were forced to conduct research, and publish papers.

Javadekar is to be loudly applauded and congratulated for taking this measure,Pushkar wrote forThe Wireat the time. The research requirement in the [Academic Performance Indicators] for college teachers was a travesty. All that it achieved was a proliferation of fake journals for college teachers to publish in.

Indeed, India has come to be known the fake journals capital of the world, partly as a result of requiring people who cannot undertake research to undertake research, and partly because research productivity has become one of the core measures of determining whether a country is a scientific superpower.

For another example, the journalNaturereportedthat Pakistans research output increased the most among all countries in the world by 21% in 2018, a feat that it dubbed a phenomenal success. However, as Anjum Altaf, former provost of Karachis Habib University and a famous teacher, subsequentlytoldThe Wire, The volume of third-rate publications in Pakistan has increased greatly simply because [Pakistans Higher Education Commission] introduced a tenure-track system and required publications for promotion.

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Sleuths Uncover Web of Research Fraud in 400+ Papers From China - The Wire

Healthcare Nanotechnology (Nanomedicine) Market report is to provide accurate and strategic analysis of the Profile Projectors industry. The report closely examines each segment and its sub-segmehnt futures before looking at the 360-degree view of the market mentioned above. Market forecasts will provide deep insight into industry parameters by accessing growth, consumption, upcoming market trends and various price fluctuations.

Global Healthcare Nanotechnology (Nanomedicine) Market research reports growth rates and market value based on market dynamics, growth factors. Complete knowledge is based on the latest innovations in the industry, opportunities and trends. In addition to SWOT analysis by key suppliers, the report contains a comprehensive market analysis and major players landscape.

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Major Key Players:

The report on the Global Healthcare Nanotechnology (Nanomedicine) Market has newly added by The Insight Partners to its huge repository. The market is expected to increase by the end of forecast period. Primary and secondary research methodologies have been used for curating this research report.

The global regions which are scrutinized for a clear understanding of Global Healthcare Nanotechnology (Nanomedicine) Market are North America, Latin America, Asia-Pacific, Africa, Europe, and India. The research on the Global Healthcare Nanotechnology (Nanomedicine) Market will be applicable to investors, business owners, industry experts, and various c level peoples. Profiling of the several top-level industries has been included in this informative report.

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The research study has taken the help of graphical presentation techniques such as info graphics, charts, tables, and pictures. It provides guidelines for both established players and new entrants in the Global Healthcare Nanotechnology (Nanomedicine) Market.

Table of Contents:

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Healthcare Nanotechnology (Nanomedicine) Market Forecast to 2027 with Key Companies Profile, Supply, Demand and SWOT Analysis - Jewish Life News

Newest Learn about at the International Nanomedicine Market

The lately printed record via Transparency Market Analysis at the world Nanomedicine marketplace provides resourceful insights referring to the long run possibilities of the Nanomedicine marketplace. The underlying developments, enlargement alternatives, impeding elements, and evident marketplace drivers are totally studied within the introduced record.

As in keeping with the record, the worldwide Nanomedicine marketplace is projected to develop at a CAGR of ~XX% and exceed the worth of ~US$ against the tip of 2029. Additionally, an in-intensity research of the micro and macro-financial elements which are expected to steer the trajectory of the Nanomedicine marketplace all through the forecast length (2019-2029) is integrated within the record.

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Important Insights Associated with the Nanomedicine Market within the Document:

Nanomedicine Market Segments

A radical analysis of the long run possibilities of the Nanomedicine marketplace throughout more than a few areas is tracked within the record.

segmentation, and demanding situations out there were mentioned at duration within the analysis record.

Review of the Cloud Computing Market in Healthcare Trade

As in keeping with the analysis record, the worldwide marketplace for cloud computing within the healthcare business used to be valued at US$1.82 bn in 2011 and is projected to succeed in a worth of US$6.79 bn via the tip of 2018. The marketplace is projected to sign up a exceptional 21.30% CAGR between 2012 and 2018.

The safety of get entry to and knowledge integrity and several other different advantages presented via cloud computing are estimated to inspire the expansion of the marketplace in the following couple of years. Alternatively, information leakage considerations, information integration and consistency, and knowledge relocation are one of the key elements estimated to restrain the expansion of the worldwide cloud computing marketplace within the healthcare business in the following couple of years.

At the moment, the instrument-as-a-provider phase leads the worldwide cloud computing marketplace within the healthcare business. However, the platform-as-a-provider phase is estimated to witness considerable enlargement within the coming years. Moreover, at the foundation of finish use, the non-scientific knowledge techniques marketplace is projected to guide the worldwide marketplace within the close to long run.

A number of the key geographical segments, North The usa is estimated develop at a swift tempo and account for an enormous proportion within the world marketplace for cloud computing within the healthcare business in the following couple of years. The top enlargement of this area may also be attributed to the presence of numerous biopharmaceutical gamers. As well as, the emerging focal point on analysis and construction actions is anticipated to give a contribution widely against the expansion of the marketplace.

Firms Discussed within the Analysis Document

The world marketplace for cloud computing within the healthcare business is very fragmented in nature as no key gamers grasp greater than a proportion of 10% out there at this time. CareCloud, ClearDATA Networks, Oracle Company, Microsoft, Agfa Healthcare, IBM Company, and Merge Healthcare are one of the key gamers running within the world cloud computing marketplace within the healthcare business.

Key Segments of the International Cloud Computing marketplace in Healthcare Trade

International Cloud Computing marketplace in Healthcare Trade, via provider fashions

International Cloud Computing marketplace in Healthcare Trade, via pricing fashions

International Cloud Computing marketplace in Healthcare Trade, via finish customers

International Cloud Computing marketplace in Healthcare Trade, via Geography

This record provides you with get entry to to decisive information equivalent to:

Key highlights of this record

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Robust Growth Of The Nanomedicine Market Predicted Over The Forecast Period 2013 - 2019 - Hitz Dairies

Clene Nanomedicines remyelination therapy candidate, CNM-Au8, showed a robust ability to stimulate the production of new myelin and increase the number of myelin-wrapped nerve fibers in the brain and spinal cord of animals in models of demyelinating disease, allowing mice to recover motor skills, a study reports.

Such preclinical data support the efficacy of this potential treatment, now being tested in clinical trials with multiple sclerosis (MS) patients.

These early findings were reported in the study Nanocatalytic activity of clean-surfaced, faceted nanocrystalline gold enhances remyelination in animal models of multiple sclerosis, published in the journalNature Scientific Reports.

In MS, the immune system attacks myelin, the protective sheath around nerve fibers or axons. Myelin is essential for the fast transmission of electrical signals between neurons, and its loss (demyelination) damages the integrity of nerve cells and their ability to communicate with each other.

Finding therapies that promote remyelination the recovery of myelin is a high priority for MS, the researchers noted.Such treatments could potentially repair demyelinating lesions in the central nervous system (the brain and spinal cord), restoring function to nerve cells affected by the disease.

Most approved MS therapies dampen the immune systems activity to prevent further myelin damage. However, they cannot undo existing damage or replace the myelin sheaths that have been lost.

Clene Nanomedicines lead compound, CNM-Au8, is a potential remyelination therapy for MS and other neurodegenerative disorders, including Parkinsons disease, and amyotrophic lateral sclerosis (ALS).

CNM-Au8 is a solution of gold (Au) nanoparticles with apatented crystal structure, named a clean-surfaced nanocrystal (CSN). According to the company, these nanocrystals have properties that make them highly biologically active, allowing them to facilitate certain energy-related reactions within cells.

In the brain, both neurons and supporting cells, includingoligodendrocytesthat produce myelin, need substantial amounts of energy to work. In fact, the brain consumes more than 25% of the bodys metabolic resources in order to sustain the efficient flux of information through its vast network of nerve fibers.

CNM-Au8 is expected to enhance key metabolic reactions in neurons and oligodendrocytes so to increase energy reserves within these cells, while decreasing the harmful molecules naturally generated by the cells metabolism. This process, which Clene calls nanocatalysis, is thought to improve the survival and function of neurons, and to support the ability of oligodendrocytes to create new myelin.

CNM-Au8 has demonstrated a good safety profile in Phase 1 studies in healthy volunteers, and preclinical studies in animal models of MS and other diseasesindicate the therapyhas both remyelination and neuroprotection effects.

Several ongoing Phase 2 trials are evaluating CNM-Au8 in neurodegenerative diseases, including two studies in people with non-active, relapsing MS.

REPAIR-MS (NCT03993171) is an open-label Phase 2 trial assessing the safety, pharmacokinetics (availability of the therapy in the body) and pharmacodynamics (its effects) of differing oral doses of CNM-Au8 in 24 adults with relapsing-remitting MS (RRMS). This study is currently enrolling eligible patients at theUniversity of Texas Southwestern. More details can be foundhere. It is expected to conclude in the fall.

Another Phase 2 trial, called VISIONARY-MS (NCT03536559), is investigating the efficacy and safety of CNM-Au8 in up to 150 adults with RRMS, who have chronic vision problems due to lesions (chronic optic neuropathy). This study is also recruiting at nine sites across Australia, and is supported by the National Multiple Sclerosis Society. Contact and site information is available here. Results from VISIONARY-MS are expected in 2021.

Now, the preclinical work by researchers at Clene Nanomedicine, Northwestern University, and George Washington Universityprovides additional evidence supporting the ability of these gold nanocrystalsto promote remyelination in cell and animal models of MS.

We are gratified at the publication of these data. These results establish the rationale for our ongoing Phase 2 clinical trial, VISIONARY-MS, which is designed to demonstrate the efficacy of CNM-Au8 for the treatment of chronic optic neuropathy in patients with non-active relapsing MS, Robert Glanzman, MD, chief medical officer of Clene Nanomedicine, said in a press release.

Researchers found that oral delivery of CNM-Au8 to mice and rat models of demyelination led to robust remyelination activity in the brain and spinal cord, leading to higher numbers of myelin-wrapped axons. Study data also showed that CNM-Au8 resulted in a greater migration of oligodendrocytes to lesion sites, and increased myelin production.

The remyelination promoted by CNM-Au8 was also matched by a significant recovery of physical abilities in the mice, evaluated using different locomotor and fine motor tests.

Working on cells in lab dishes, known as in vitro assays, the scientists showed that treating oligodendrocyte precursor cells with CNM-Au8 stimulated their differentiation and maturation, and the expression of myelin-related markers.

The gold nanocrystals were seen to act via a novel energy metabolism pathway that speeds the conversion of NADH to NAD+, a critical factor for sensing and producing energy in cells. CNM-Au8 also increased the levels of adenosine triphosphate (ATP), a small molecule used as fuel by cells, and turned on genes related to myelin production, collectively resulting in functional myelin generation, the researchers reported.

These results further validate our entirely new approach using therapeutic gold nanocatalysts as a mechanism to support the cellular viability and enhanced function of neurons and oligodendrocytes, saidKaren Ho, PhD, one of the studys authors and director of Translational Medicine at Clene Nanomedicine.

CNM-Au8 is one of a limited number of drugs being developed which have demonstrated remyelination capabilities. We believe these data exemplify a strong step forward in the development of a treatment to improve function in the lives of more than one million people living with MS in the U.S., Ho concluded.

Ana is a molecular biologist with a passion for discovery and communication. As a science writer, she looks for connecting the public, in particular patients and healthcare providers, with clear and quality information about the latest medical advances. Ana holds a Ph.D. in Biomedical Sciences from the University of Lisbon, Portugal, where she specialized in infectious diseases, epigenetics, and gene expression.

Total Posts: 1,053

Patrcia holds her PhD in Medical Microbiology and Infectious Diseases from the Leiden University Medical Center in Leiden, The Netherlands. She has studied Applied Biology at Universidade do Minho and was a postdoctoral research fellow at Instituto de Medicina Molecular in Lisbon, Portugal. Her work has been focused on molecular genetic traits of infectious agents such as viruses and parasites.

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Remyelination Potential of MS Therapy in Phase 2 Testing Evident in Animal Work, Study Says - Multiple Sclerosis News Today

Annual Report: CIBBIM Nanomedicine
The area studies the use of nanotechnology in biomedical applications mainly with two purposes: first, to improve therapeutic strategies and second, to impro...

By: VHIRtv

Excerpt from:
Annual Report: CIBBIM Nanomedicine - Video

Fatima Aouidat,1 Sarah Boumati,2 Memona Khan,1 Frederik Tielens,3 Bich-Thuy Doan,2 Jolanda Spadavecchia1

1CNRS, UMR 7244, CSPBAT, Laboratory of Chemistry, Structures and Properties of Biomaterials And Therapeutic Agents University Paris 13, Sorbonne Paris Cit, Bobigny, France; 2UTCBS Chimie ParisTech University Paris Descartes - CNRS UMR 8258 INSERM U1022 Equipe Synthesis, Electrochemistry, Imaging and Analytical Systems for Diagnostics SEISAD, Paris, France; 3General Chemistry (ALGC), Vrije University of Brussel (Free University Brussels-VUB), Brussel, Belgium

Correspondence: Jolanda Spadavecchia Email jolanda.spadavecchia@univ-paris13.fr

Introduction: The development of biopolymers for the synthesis of Gd(III) nanoparticles, as therapeutics, could play a key role in nanomedicine. Biocompatible polymers are not only used for complex monovalent biomolecules, but also for the realization of multivalent active targeting materials as diagnostic and/or therapeutic hybrid nanoparticles. In this article, it was reported for the first time, a novel synthesis of Gd(III)biopolymerAu(III) complex, acting as a key ingredient of core-shell gold nanoparticles (Gd(@AuNPs).Material and methods: The physical and chemical evaluation was carried out by spectroscopic analytical techniques (Raman spectroscopy, UV-visible and TEM). The theoretical characterization by DFT (density functional theory) analysis was carried out under specific conditions to investigate the interaction between the Au and the Gd precursors, during the first nucleation step. Magnetic features with relaxivity measurements at 7T were also performed as well as cytotoxicity studies on hepatocyte cell lines for biocompatibility studies. The in vivo detailed dynamic biodistribution studies in mice to characterize the potential applications for biology as MRI contrast agents were then achieved.Results: Physicalchemical evaluation confirms the successful design and reaction supposed. Viabilities of TIB-75 (hepatocytes) cells were evaluated using Alamar blue cytotoxic tests with increasing concentrations of nanoparticles. In vivo biodistribution studies were then accomplished to assess the kinetic behavior of the nanoparticles in mice and characterize their stealthiness property after intravenous injection.Conclusion: We demonstrated that Gd@AuNPs have some advantages to display hepatocytes in the liver. Particularly, these nanoconjugates give a good cellular uptake of several quantities of Gd@NPs into cells, while preserving a T1 contrast inside cells that provide a robust in vivo detection using T1-weighted MR images. These results will strengthen the role of gadolinium as complex to gold in order to tune Gd(@AuNPs) as an innovative diagnostic agent in the field of nanomedicine.

Keywords: Gd-gold complex, theoretical study, MRI, relaxivity, biodistribution

This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License.By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

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Nanomedicine: towards development of patient-friendly drug-delivery systems
ES-Cancer Focus Group. Third Journal Club: Nanomedicine: towards development of patient-friendly drug-delivery systems for oncological applications.

By: Egypt Scholars Inc.

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Nanomedicine: towards development of patient-friendly drug-delivery systems - Video

Ideas @Davos | Sonia Trigueros | Breakthroughs in Nanomedicine
http://www.weforum.org/ Growing tolerance to antibiotics means that there are more people dying of infection than cancer. Breakthrough discoveries in nanomed...

By: World Economic Forum

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Ideas @Davos | Sonia Trigueros | Breakthroughs in Nanomedicine - Video

NANOMEDICINE HANGOUT1

By: NanoMedicine

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NANOMEDICINE HANGOUT1 - Video

Nanomedicine Meaning
Video shows what nanomedicine means. The use of nanotechnology for diagnosing, treating and preventing disease.. Any medicine containing nanoparticles.. Nanomedicine Meaning. How to ...

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Nanomedicine Meaning - Video

Cancer itself is a very broad based topic. There are various forms of cancer and many different types of diagnostics and treatments that are currently available. In our earlier articles, we have touched on various aspects of cancer:

- Key facts with statistics - Major causes- The correlation between employment and the illness- Risk reduction- Types of treatment available- Treatment cost overview- Integrative and Preventive Medicine

So far, the treatment model that is proven by several sources to have the best results is through Integrative Medicine. Its approach is to combine conventional methods with both complementary and alternative therapies. It is very patient-centred, making use of natural products, modification of lifestyle, diet, a mind-body-spirit healing journey together with conventional treatments like chemotherapy.

Dr. ChatChai Sribundit (M.D) from Akesis Life Bangkok (akesisoncology.com) emphasises the important role that integrative medicine plays in todays cancer management and in many cancer-care programs. As he mentioned in earlier articles, almost one third of cancer cases are actually preventable. Risk factors can be eliminated and implementing existing evidence-based preventive strategies are definitely the winning formula.

In the long run, preventive strategies in the form of regular exercise and maintaining a healthy weight reduces the risk not only of cancer but many other primary medical conditions. In addition, a well-balanced lifestyle and healthy food provide both long and short term benefits. Apart from the above, Dr. Chatchai stands firmly by his 5 pillars consisting of medical intervention, diet & nutrition, physical therapy & exercise, emotional wellness and patient education.

Together with the basis of the 5 Pillars, early detection with timely and proper patient management can greatly reduce cancer risk. Many cancers have a high chance of cure if diagnosed early and treated adequately.

Chemotherapy and radiotherapy remain a mainstream form of treatment whereas tissue biopsy and scans are general diagnostic tools commonly used in Conventional therapies for cancer. In some cases, a targeted approach is lacking and patients can be vulnerable to certain types of drugs. Recently, new treatments have been emerging to improve the traditional options in cancer treatment with poor prognosis. Areas like nanomedicine and extracellular vesicles along with advances in immunotherapy and nanotechnology are becoming a norm for the next generation of cancer diagnosis and treatments.

Liquid Biopsy

Molecular targeting of specific oncogenic mutations in human cancer is now key for anti-cancer drug therapy as mutations lead to drug resistance. Therefore, the ability to detect and continuously monitor oncogenic mutations is important as it guides the use of targeted molecular therapies to improve long-term clinical outcomes in patients. Apart from direct sampling of cancer tissue by biopsy, oncogenic mutations are also detectable in circulating bodily fluids of patients which is a less invasive method.

Cancer biomarker discovery using DNA aptamersBiomarkers are molecules able to indicate specific physiological states of cells. Identifying reliable biomarkers is essential for early diagnosis and adaptive treatment strategies. According to pub.vsc.org, aptamers are single-stranded oligonucleotides generated by an in vitro screening method called Systematic Evolution of Ligands by Exponential Enrichment (SELEX). They can recognise their cognate targets with selectivity and affinity comparable to protein antibodies in cancer patients.

Nanomedicine

Treating cancer with nanotechnology has become one of the emerging trends. Studies reveal that treating cancer by nanoparticle enhances the efficiency of the treatment and also minimises adverse effects. The property of nanoparticles in treating cancer is target specific. Nanoparticles also target uncontrolled cell proliferation.

Extracellular vesicles (EVs) are released by all cells within the tumour microenvironment, such as endothelial cells, tumour-associated fibroblasts, pericytes, and immune system cells. The EVs carry the load of parental cells formed of proteins and nucleic acids, that convey cell-to-cell communication and also suppress tumour progression. Due to longevity of vesicles within the circulation and their ability to cross bloodbrain barriers, modification of these unique organelles offers the potential to create new biological-tools for cancer therapy.

These treatments help ones immune system to find and attack cancer cells the same way it attacks bacteria and viruses. It uses substances made by the body or in a laboratory to improve or restore immune system function. Immunotherapy may work by maximising the immune system to prevent or slow down the growth of cancer and reduce the probability of spreading. Some examples of immunotherapy, include, NK Cell therapy, Cancer vaccines (prophylactic or therapeutic) and T-cell therapy.

Commonly use in Integrative medicine and in conjunction with radiation, hyperthermia is a non-invasive method of increasing tumour temperature to stimulate blood flow and improve oxygenation. This makes cancer cells more sensitive during radiation therapy. Hyperthermia helps address the limitations of radiation for many patients by effectively increasing the radiation dose without increasing in unwanted side effects. There are significant results which show the effect of hyperthermia approach in treating cancer.

Longdom.org states that this treatment uses a drug called photosensitizer or photosensitizing agents. Agents and particular type of light are exposed at a specific wavelength. The specificity of wavelength depends on the production of oxygen. Oxygen destroys nearby Cancer cells. The wave length determines the distance travelled by the light into the body. The photosensitizer present in a tumour absorbs the light and produces oxygen which destroys surrounding cancer cells.

This treatment uses light amplification by the stimulated emission of radiation. Laser therapy for treating cancer includes special light beams instead of instruments. Laser therapy is normally given through an endoscopic tube. There are different types of laser therapies used for treatment of cancer. The Endoscope is inserted in the body to treat cancer or precancerous growth. Lasers can also be used to shrink or destroy tumours or precancerous growth.

The initial stage, which is most important, is the detection of cancer. Early detection could increase the possibility of cure and increases survival rates. However, poor prognosis due to lack of proper diagnosing methods and ineffective chemotherapeutic treatment is a common hurdle. As synthetic drugs cause many side effects, and cancer cells become resistant, more innovative treatment methods must be considered to give new hope for existing sufferers.

Author: Ezree Ebrahim, Business Development Consultant (Healthcare), Akesis Life by Absolute Health. For Further information, please contact: ezree.ebrahim@akesisoncology.com

Series Editor: Christopher F. Bruton, Executive Director, Dataconsult Ltd, chris@dataconsult.co.th. Dataconsults Thailand Regional Forum provides seminars and extensive documentation to update business on future trends in Thailand and in the Mekong Region.

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Cancer in the workplace: Innovative diagnostic devices and treatments - Bangkok Post

Healthcare Nanotechnology (Nanomedicine) Market Report Delivering Growth Analysis with Key Trends of Top Companies (2020-2026)

A comprehensive research study on the Healthcare Nanotechnology (Nanomedicine) Marketwas recently published by Market Report Expert. This is an up-to-date report, covering the current COVID-19 impact on the market. The Coronavirus (COVID-19) has affected every aspect of life globally and thus altering the global market scenario. The changes in the market conditions are drastic. The swiftly changing market scenario and initial and future assessment of the impact on Healthcare Nanotechnology (Nanomedicine) market is covered in the report.The Healthcare Nanotechnology (Nanomedicine) Market report is a precise and deep-dive study on the current state that aims at the major drivers, market strategies, and imposing growth of the key players. Worldwide Healthcare Nanotechnology (Nanomedicine) Industry also offers a granular study of the dynamics, segmentation, revenue, share forecasts, and allows you to make superior business decisions. The report serves imperative statistics on the market stature of the prominent manufacturers and is an important source of guidance and advice for companies and individuals involved in the Healthcare Nanotechnology (Nanomedicine) industry.

The Global Healthcare Nanotechnology (Nanomedicine) Market poised to grow from US$ XX million in 2020 to US$ XX million by 2026 at a compound annual growth rate (CAGR) of XX% during the projection period of 2020-2026.

An Outline of the Major Key Players covered in this Report:

Amgen, Teva Pharmaceuticals, Abbott, UCB, Roche, Celgene, Sanofi, Merck& Co, Biogen, Stryker, Gilead Sciences, Pfizer, 3M Company, Johnson& Johnson, Smith&Nephew, Leadiant Biosciences, Kyowa Hakko Kirin, Shire, Ipsen, Endo International

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The report puts together a succinct analysis of the growth drivers influencing the current business scenario across various regions and countries. Substantial information pertaining to the industry analysis size, share, application, and statistics are summed in the report in order to present a collaborative prediction. Additionally, this report encompasses a precise competitive analysis of major market players, innovative companies, and their strategies during the projection timeline.

The latest report on the Healthcare Nanotechnology (Nanomedicine) Market consists of an analysis of this industry and its type, application, and other segments. As per the report, the market is estimated to gain significant returns and register substantial y-o-y growth during the forecast period of 2020-2026.

Majortype, primarily split into

NanomedicineNano Medical DevicesNano DiagnosisOther

Major applications/end users, including

AnticancerCNS ProductAnti-infectiveOther

According to the report, the study offers details regarding the valuable estimations of the market such as market size, sales capacity, and profit projections. The report documents factors such as drivers, restraints, and opportunities that impacts the remuneration of this market.

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The research offers an analysis of the geographical landscape of the Healthcare Nanotechnology (Nanomedicine) Market, which is divided into regions such as North America, Europe, Asia Pacific, South America, and the Middle East & Africa. The segment includes data about several parameters related to the regional contribution such as market share, application share, type share, key companies in respective regions, market share of key companies in regional market, growth rate and revenue of the regional market, sales, production, and consumption of the respective Healthcare Nanotechnology (Nanomedicine) market.

Major Highlights of TOC Covers:

Healthcare Nanotechnology (Nanomedicine) Market 2020, Healthcare Nanotechnology (Nanomedicine) Market size, Healthcare Nanotechnology (Nanomedicine) Market share, Healthcare Nanotechnology (Nanomedicine) Market analysis, Healthcare Nanotechnology (Nanomedicine) Market forecast, Healthcare Nanotechnology (Nanomedicine) Market trends, Healthcare Nanotechnology (Nanomedicine) Market Research report, Healthcare Nanotechnology (Nanomedicine) application, Healthcare Nanotechnology (Nanomedicine) Trends, Healthcare Nanotechnology (Nanomedicine) Market growing CAGR, Healthcare Nanotechnology (Nanomedicine) Market Competitive Landscape, Healthcare Nanotechnology (Nanomedicine) Market Growth

Information related to the growth rate, revenue, sales, production, consumption, during the forecast period is included in the report. The Healthcare Nanotechnology (Nanomedicine) Market report claims that the industry is projected to generate significant revenue and sales during the forecast period. The report consists of information related to the market dynamics such as challenges involved in this vertical, growth opportunities, and driving factors affecting the market.

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COVID-19 Impact on Healthcare Nanotechnology (Nanomedicine) Market Analysis, Trends, Growth and Forecast 2020 to 2026| Amgen, Teva Pharmaceuticals,...

VANCOUVER, BC, Oct. 23, 2020 /CNW/ -Precision NanoSystems Inc. (PNI), a global leader in technologies and solutions in genetic medicine, announced today that it has received a commitment of up to $18.2 million in support from the Government of Canada under the Innovation, Science and Economic Development's (ISED) Strategic Innovation Fund (SIF) to develop a COVID-19 vaccine. PNI will use the investment to advance a best-in-class COVID-19 mRNA vaccine candidate to clinical trials.

PNI provides over 250 industry and academic partners with solutions for the development of vaccines, gene therapies, and cell therapies, in the areas of infectious diseases, oncology and rare diseases. With this investment from the Government of Canada, PNI's Chief Scientific Officer, Dr. Andrew Geall, and his team will use their state-of-the-art technology platforms and expertise in self-amplifying mRNA vectors, lipid-based drug delivery systems and nanomedicine manufacturing to develop a cost-effective COVID-19 vaccine.

As part of Canada's efforts to combat COVID-19, the Strategic Innovation Fund is working diligently to support projects led by the private sector for COVID-19 related vaccine and therapy clinical trials to advance Canada's medical countermeasures in the fight against COVID-19. "An effective vaccine will be critical as we work to contain the COVID-19 virus and prevent future infections.Today's contribution will support PNI to advance the development of a mRNA vaccine candidate through pre-clinical studies and clinical trials to help protect Canadians," stated the Honourable Navdeep Bains, Minister of Innovation, Science and Industry.

Bringing together its proprietary technology platforms, key partnerships and unparalleled expertise in nanomedicines, PNI is excited to be leading the development of a Made-in-Canada COVID vaccine. James Taylor, CEO and co-founder of PNI said "Since its inception PNI has executed on its mission to accelerate the creation of transformative medicines. It is an honour to be supported by the Canadian government in this global fight against COVID-19 and to further build capabilities for rapid response against COVID-19 and future pandemics"

About Precision NanoSystems Inc. (PNI)

PNI is a global leader in ushering in the next wave of genetic medicines in infectious diseases, cancer and rare diseases. We work with the world's leading drug developers to understand disease and create the therapeutics and vaccines that will define the future of medicine.PNI offers proprietary technology platforms and comprehensive expertise to enable researchers to translate disease biology insights into non-viral genetic medicines.

SOURCE Precision Nanosystems

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Precision NanoSystems Receives $18.2 Million from the Government of Canada to Develop an RNA Vaccine for COVID-19 - BioSpace

Nanomedicine Market

UpMarketResearch, 29-07-2020: The research report on the Nanomedicine Market is a deep analysis of the market. This is a latest report, covering the current COVID-19 impact on the market. The pandemic of Coronavirus (COVID-19) has affected every aspect of life globally. This has brought along several changes in market conditions. The rapidly changing market scenario and initial and future assessment of the impact is covered in the report. Experts have studied the historical data and compared it with the changing market situations. The report covers all the necessary information required by new entrants as well as the existing players to gain deeper insight.

Furthermore, the statistical survey in the report focuses on product specifications, costs, production capacities, marketing channels, and market players. Upstream raw materials, downstream demand analysis, and a list of end-user industries have been studied systematically, along with the suppliers in this market. The product flow and distribution channel have also been presented in this research report.

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The Major Manufacturers Covered in this Report:CombimatrixAblynxAbraxis BioscienceCelgeneMallinckrodtArrowhead ResearchGE HealthcareMerckPfizerNanosphereEpeius BiotechnologiesCytimmune SciencesNanospectra Biosciences

The Research Study Focuses on:

By Types:Quantum dotsNanoparticlesNanoshellsNanotubesNanodevices

By Applications:Segmentation encompasses oncologyInfectious diseasesCardiologyOrthopedicsOthers

By Regions:

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The Nanomedicine Market Report Consists of the Following Points:

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In conclusion, the Nanomedicine Market report is a reliable source for accessing the research data that is projected to exponentially accelerate your business. The report provides information such as economic scenarios, benefits, limits, trends, market growth rate, and figures. SWOT analysis is also incorporated in the report along with speculation attainability investigation and venture return investigation.

About UpMarketResearch:Up Market Research (https://www.upmarketresearch.com) is a leading distributor of market research report with more than 800+ global clients. As a market research company, we take pride in equipping our clients with insights and data that holds the power to truly make a difference to their business. Our mission is singular and well-defined we want to help our clients envisage their business environment so that they are able to make informed, strategic and therefore successful decisions for themselves.

Contact Info UpMarketResearchName Alex MathewsEmail [emailprotected]Organization UpMarketResearchAddress 500 East E Street, Ontario, CA 91764, United States.

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Nanomedicine Market Report (2019-2027) | The demand for the Market will drastically increase in the Future? - Research Newspaper

Note: Due to the pandemic, we have included a special section on the Impact of COVID 19 on the Radiocontrast AgentMarket which would mention How the Covid-19 is Affecting the Industry, Market Trends and Potential Opportunities in the COVID-19 Landscape, Key Regions and Proposal for Radiocontrast Agent Market Players to battle Covid-19 Impact.

The Radiocontrast AgentMarket report is compilation of intelligent, broad research studies that will help players and stakeholders to make informed business decisions in future. It offers detailed research and analysis of key aspects of the Radiocontrast Agent market. Readers will be able to gain deeper understanding of the competitive landscape and its future scenarios, crucial dynamics, and leading segments of the global Radiocontrast Agent market. Buyers of the report will have access to accurate PESTLE, SWOT and other types of analysis on the global Radiocontrast Agent market. Moreover, it offers highly accurate estimations on the CAGR, market share, and market size of key regions and countries. Players can use this study to explore untapped Radiocontrast Agent markets to extend their reach and create sales opportunities.

The study encompasses profiles of major Companies/Manufacturers operating in the global Radiocontrast Agent Market.Key players profiled in the report include:GE Healthcare (US), Bracco Imaging (Italy), Bayer HealthCare (Germany), Guerbet (France), Lantheus (US), Daiichi Sankyo (Japan), Unijules Life Sciences (India), J.B. Chemicals and Pharmaceuticals (India), Spago Nanomedicine (Sweden), Taejoon Pharm (South Korea), Jodas (India), Magnus Health (India) and More

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Segmental Analysis:The report has classified the global Radiocontrast Agent market into segments including product type and application. Every segment is evaluated based on share and growth rate. Besides, the analysts have studied the potential regions that may prove rewarding for the Radiocontrast Agent manufcaturers in the coming years. The regional analysis includes reliable predictions on value and volume, there by helping market players to gain deep insights into the overall Radiocontrast Agent industry.

Market Segment By Type:Barium-based Radiocontrast AgentIodinated Radiocontrast AgentGadolinium-based Radiocontrast AgentMicrobubble Radiocontrast AgentX-ray/Computed Tomography (CT)Magnetic Resonance Imaging (MRI)UltrasoundMarket Segment By Application:RadiologyInterventional RadiologyInterventional Cardiology

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The authors of the report have analyzed both developing and developed regions considered for the research and analysis of the global Radiocontrast Agent market. The regional analysis section of the report provides an extensive research study on different regional and country-wise Radiocontrast Agent industry to help players plan effective expansion strategies.

Regions Covered in the Global Radiocontrast Agent Market: The Middle East and Africa (GCC Countries and Egypt) North America (the United States, Mexico, and Canada) South America (Brazil etc.) Europe (Turkey, Germany, Russia UK, Italy, France, etc.) Asia-Pacific (Vietnam, China, Malaysia, Japan, Philippines, Korea, Thailand, India, Indonesia, and Australia)

Years Considered to Estimate the Market Size:History Year: 2015-2019Base Year: 2019Estimated Year: 2020Forecast Year: 2020-2025

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Impact of COVID-19 on Radiocontrast Agent Market Global Industry Outlook, Share, Growth Analysis, Trends and top manufacture like GE Healthcare (US),...

Scientists in the cancer nanomedicine community debate whether use of nanoparticles can best deliver drug therapy to tumors passively, allowing the nanoparticles to diffuse into tumors and become held in place, or actively, adding a targeted anti-cancer molecule to bind to specific cancer cell receptors and, in theory, keep the nanoparticle in the tumor longer. Now, new research on human and mouse tumors in mice by investigators at the Johns Hopkins Kimmel Cancer Center suggests the question is even more complicated.

Laboratory studies testing both methods in six models of breast cancer; five human cancer cell lines and one mouse cancer in mice with three variants of the immune system found that nanoparticles coated with trastuzumab, a drug that targets human epidermal growth factor receptor 2 (HER2)-positive breast cancer cells, were better retained in the tumors than plain nanoparticles, even in tumors that did not express the pro-growth HER2 protein. However, immune cells of the host exposed to nanoparticles induced an anti-cancer immune response by activating T cells that invaded and slowed tumor growth. The results of the work Nanoparticle interactions with immune cells dominate tumor retention and induce T cellmediated tumor suppression in models of breast cancer, appears in Science Advances.

The factors that influence nanoparticle fate in vivo following systemic delivery remain an area of intense interest. Of particular interest is whether labeling with a cancer-specific antibody ligand (active targeting) is superior to its unlabeled counterpart (passive targeting). Using models of breast cancer in three immune variants of mice, we demonstrate that intratumor retention of antibody-labeled nanoparticles was determined by tumor-associated dendritic cells, neutrophils, monocytes, and macrophages and not by antibody-antigen interactions, write the investigators.

Systemic exposure to either nanoparticle type induced an immune response leading to CD8+ T cell infiltration and tumor growth delay that was independent of antibody therapeutic activity. These results suggest that antitumor immune responses can be induced by systemic exposure to nanoparticles without requiring a therapeutic payload. We conclude that immune status of the host and microenvironment of solid tumors are critical variables for studies in cancer nanomedicine and that nanoparticle technology may harbor potential for cancer immunotherapy.

Its been known for a long time that nanoparticles, when injected into the bloodstream, are picked up by scavenger-like macrophages and other immune system cells, explains senior study author Robert Ivkov, PhD, associate professor of radiation oncology and molecular radiation sciences at the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins.

Many researchers in the field have been focused on trying to reduce interactions with immune cells, because they have been trying to increase the circulation time of the nanoparticles and their retention in tumor cells. But our study demonstrates that the immune cells in the tumor collect and react to the particles in such a way to stimulate an anti-cancer response. This may hold potential for advancing beyond drug delivery toward developing cancer immunotherapies.

The investigators conducted a few in vitro experiments in their study. First, they applied some plain starch-coated iron oxide nanoparticles and others coated with trastuzumab to five human breast cancer cell lines, finding that the amount of binding between the trastuzumab-coated nanoparticles and cells depended on how much the cancer cells expressed the oncogene HER2. In people, HER2-positive breast cancers are among the most resistant to standard chemotherapy.

Trastuzumab, sold under the name Herceptin, targets the HER2-positive tumor cells and triggers the immune system as well.

Responses were surprisingly different in animal models, the researchers report. In separate experiments, the team used the nanoparticles in two immune-deficient strains of mice engrafted with cells from five human breast cancer cell linestwo that were HER2 negative and three that were HER2 positive. When they studied the animals tumors 24 hours later, they noticed that nanoparticles coated with trastuzumab were found in a concentration two to five times greater than the plain nanoparticles in all types of tumors, regardless of whether they expressed the HER2 protein. They also found that the number of trastuzumab-coated nanoparticles was even greater (tenfold) in mice that had a fully functional immune system and were bearing mouse-derived tumors.

This led the researchers to suspect that the host animals immune systems were interacting strongly with the nanoparticles and playing a role in determining retention of the particles in the tumor, whether or not a drug was added.

More experiments, the team reports, revealed that tumor-associated immune cells were responsible for collecting the nanoparticles, and that mice bred with an intact immune system retained more of the trastuzumab-coated nanoparticles than mice bred without a fully functioning immune system.

In addition, inflammatory immune cells in the tumors immediate surroundings, or microenvironment, seized more of the coated nanoparticles than the plain ones. Finally, in a series of 30-day experiments, the researchers found that exposure to nanoparticles inhibited tumor growth three to five times more than controls, and increased CD8-positive cancer-killing T cells in the tumors.

Surprisingly, Ivkov notes, the anti-cancer immune activating response was equally effective with exposure to either plain or trastuzumab-coated nanoparticles. Mice with defective T cells did not show tumor growth inhibition. The investigators say this demonstrated that systemic exposure to nanoparticles can cause a systemic host immune response that leads to anti-cancer immune stimulation and does not require nanoparticles to be inside the tumors.

Overall, our work suggests that complex interdependencies exist between the host and tumor immune responses to nanoparticle exposure, Ivkov says. These results offer intriguing possibilities for exploring nanoparticle targeting of the tumor immune microenvironment. They also demonstrate exciting new potential to develop nanoparticles as platforms for cancer immune therapies.

The investigators say they also plan to study whether the same types of immune responses can be generated for noncancer conditions, such as infectious diseases.

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What Might be the Best Way to Delivery Nanoparticle Therapy for Cancer? - Genetic Engineering & Biotechnology News

The research report on the Nanomedicine Market offers a comprehensive study on market share, size, growth aspects, and major players. In addition, the report contains brief information about the regional competitive landscape, market trends, and drivers, opportunities and challenges, distributors, sales channels, risks & entry barriers, as well as Porters Five Forces Analysis. Moreover, the main objective of this report is to offer a detailed analysis of how the market aspects potentially influence the coming future of the Nanomedicine market. The report also offers a comprehensive analysis about the competitive manufacturers as well as the new entrants also studies along with their brief research.

The report includes the latest coverage of the impact of COVID-19 on the Nanomedicine industry. The incidence has affected nearly every aspect of the business domain. This study evaluates the current scenario and predicts future outcomes of the pandemic on the global economy.

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In addition, this report also contains a price, revenue, market share, and production of the service providers is also mentioned with accurate data. Moreover, the global Nanomedicine report majorly focuses on the current developments, new possibilities, advancements, as well as dormant traps. Furthermore, the Nanomedicine market report offers a complete analysis of the current situation and the advancement possibilities of the Nanomedicine market across the globe. This report analyses substantial key components such as production, capacity, revenue, price, gross margin, sales revenue, sales volume, growth rate, consumption, import, export, technological developments, supply, and future growth strategies.

We provide a detailed analysis of key players operating in the Nanomedicine Market:

Moreover, the Nanomedicine report offers a detailed analysis of the competitive landscape in terms of regions and the major service providers are also highlighted along with attributes of the market overview, business strategies, financials, developments pertaining as well as the product portfolio of the Nanomedicine market. Likewise, this report comprises significant data about market segmentation on the basis of type, application, and regional landscape. The Nanomedicine market report also provides a brief analysis of the market opportunities and challenges faced by the leading service provides. This report is specially designed to know accurate market insights and market status.

By Regions:

* North America (The US, Canada, and Mexico)

* Europe (Germany, France, the UK, and Rest of the World)

* Asia Pacific (China, Japan, India, and Rest of Asia Pacific)

* Latin America (Brazil and Rest of Latin America.)

* Middle East & Africa (Saudi Arabia, the UAE, , South Africa, and Rest of Middle East & Africa)

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Table of Content

1 Introduction of Nanomedicine Market

1.1 Overview of the Market1.2 Scope of Report1.3 Assumptions

2 Executive Summary

3 Research Methodology

3.1 Data Mining3.2 Validation3.3 Primary Interviews3.4 List of Data Sources

4 Nanomedicine Market Outlook

4.1 Overview4.2 Market Dynamics4.2.1 Drivers4.2.2 Restraints4.2.3 Opportunities4.3 Porters Five Force Model4.4 Value Chain Analysis

5 Nanomedicine Market, By Deployment Model

5.1 Overview

6 Nanomedicine Market, By Solution

6.1 Overview

7 Nanomedicine Market, By Vertical

7.1 Overview

8 Nanomedicine Market, By Geography

8.1 Overview8.2 North America8.2.1 U.S.8.2.2 Canada8.2.3 Mexico8.3 Europe8.3.1 Germany8.3.2 U.K.8.3.3 France8.3.4 Rest of Europe8.4 Asia Pacific8.4.1 China8.4.2 Japan8.4.3 India8.4.4 Rest of Asia Pacific8.5 Rest of the World8.5.1 Latin America8.5.2 Middle East

9 Nanomedicine Market Competitive Landscape

9.1 Overview9.2 Company Market Ranking9.3 Key Development Strategies

10 Company Profiles

10.1.1 Overview10.1.2 Financial Performance10.1.3 Product Outlook10.1.4 Key Developments

11 Appendix

11.1 Related Research

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