For Homeless Californians, The Doctor Is Often The ER Street Medicine Aims To Change That – KPBS

Instead of trying to powerwash the problem away, Californias hospitals, public health departments, and homeless service organizations are increasingly sending trained health practitioners into homeless encampments in a quest to improve health outcomes for individual homeless people.

Aired: September 30, 2019 | Transcript

Dr. Coley King of the Venice Family Clinic is one of a growing number of medical professionals making house calls to the homeless.

Instead of trying to powerwash the problem away, Californias hospitals, public health departments, and homeless service organizations are increasingly sending trained health practitioners into homeless encampments in a quest to improve health outcomes for individual homeless people.

Western medicine is very much built around the ideal care for the ideal patient. Most of these folks are not in the ideal situation, said King. We can make some compromises that still do good medical care and get them to a very good average. It's better to take half of your medicine than none of your medicine.

One late September day, King makes a house call on Shawnda Thornton, a homeless woman in her late 40s living on the sidewalk across the street from a Silicon Beach tech campus in Venice.

OK, how are you feeling now on these medications? he asked her.

I love these medications because I'm not tired. I don't have to sleep all day. I can walk around and manage myself just like I used to, she responded.

Thornton has congestive heart failure, and September is the first month this year that she hasnt been hospitalized.

The goal King has for Thornton is to ensure she has access to ongoing medical care that keeps her out of the hospital. He thinks a lot of the public discussion that revolves around Californias crisis of homelessness misses the individual people who are physically deteriorating because they lack shelter.

The pitfall of labeling it a public health crisis is it becomes a reactionary not-in-my-backyard issue, said King. Thats not what this is about. This is about the individuals who are sicker than the rest of us, and who are dying sooner than the rest of us.

Homelessness Has A Body Count

The reality of Californias homelessness crisis is that it has a body count. Life expectancy for those who are living outside is about 30 years shorter than those who are housed. The median age of death outside is about 52.

The most comprehensive study of mortality on the street available comes from Boston. It found that two of the three most common causes of death were heart disease and cancer.

Los Angeles County, the epicenter of the states homelessness crisis, is expected to see more than 1,000 people die while experiencing homelessness this year. Last year the number was 921. In Orange County in 2018, it was 210; San Francisco, 135;. Sacramento, 132.

Distinct from the plainly human toll, the amount of money spent on the medical care of the sickest homeless people, many who eventually die on the street or in the hospital care, is mind-bogglingly high.

A 2016 study found that L.A. County spent nearly $400 million in one year on its so-called frequent flyers the 5 percent of the homeless population in poorest health who most frequently cycle through publicly operated institutions like jails and hospitals. A RAND estimate placed the individual cost per person for another particularly sick study group around $38,000 annually. Neither of those estimates includes insurance costs typically paid out by Californias Medi-Cal program.

A Futility Merry-Go-Round

Corrine Feldman of USCs Keck School of Medicine studies health care for homeless patients. She calls the persistent cycle of emergency hospitalizations a futility merry-go-round.

We all sort of end up on this seemingly never-ending merry-go-round together, and no one feels good about it, said Feldman. The ER provider who's seen the same person five times in the last five shifts, recognizes wholeheartedly that the plan that they have is not going to work, the patient is going to come back, and around we go again on the merry-go-round.

There is some, but relatively limited, evidence that shows doctors deployed to homeless encampments directly reduces public health care expenditures. There are also patient-centered studies that show regular visits from health practitioners has been shown to increase homeless patients engagement with primary care and behavioral care services.

Street medicine has been a vehicle to stop the merry-go-round a little bit, Feldman said. If we do this differently, and look at the problem differently, and tackle it together, we can at least maybe slow down the merry-go-round. Maybe we can stop it all together.

The logistics of how street medicine teams are funded and deployed varies from county to county. In the case of Los Angeles, county agencies dole out grants to free clinics, hospitals, and contracts health providers directly to provide street outreach. Hospitals and other foundations also offer to fund programs too. On a typical weekday, L.A. county officials say there are 38 outreach teams of doctors, nurse practitioners, physician assistants and mental health professions out working.

That means theyre providing basic primary care, basic psychiatry, enrolling people in Medi-Cal insurance, setting referral appointments and arranging transportation for homeless individuals to clinics.

Street medicine is practiced in most California counties where there is street homelessness. Besides Los Angeles County, San Francisco, San Mateo, Santa Clara, Alameda, Ventura, San Diego, Santa Barbara, Riverside, and Sacramento counties have dedicated public or private funding for some health-oriented homeless outreach.

Earlier this year, Orange Countys CalOptima health system proposed earmarking $100 million for homeless health care, including street medical teams.

But the process to do so has been complicated after objections from local hospitals. They argued in an August 2019 letter to CalOptima that not including private hospitals in the planning process would inevitably hamstring the effort.

The health system first proposed the project after learning that three-quarters of the 210 homeless people who died in Orange County in 2018 were enrolled in CalOptima.

The Street Is No Place To Heal

The challenge for CalOptima is the same confounding public health officials across the state; How do you get quality medical care to people who neither have shelter, money, nor (typically), transportation?

According to advocates, street medicine is a first step to proactively including people in a health care system that otherwise excludes them until the last possible minute. Dr. King says street medicine is a start, but what he really pines for is the ability to write a prescription for a patient for a housing unit with affordable rent.

My novel intervention for all the illness that comes with chronic homelessness would be affordable housing, said King. But right now, I'm left with trying to give good health care to these folks, trying to find them, engage them and make them welcome in my clinic.

As for his patient, Shawnda Thornton, when it comes to getting off the street, shes actually doing better than most. After more than three years of waiting, she obtained a Section 8 housing voucher. Her challenge now is finding a place to use it. While shes had several appointments to meet with property managers, she hasnt been able to because shes been so sick.

Every time I had an appointment, I would be in the hospital, said Thornton.

Which means now her voucher is close to expiring, Dr. Kings job is to make sure she stays on her meds, stays out of the hospital, and has time to actually find a place where she can heal that isnt a red nylon tent.

You can work on it, its certainly a place to start working. But to fully heal out here, I dont think its possible, Thornton said.

Editor's note: In an earlier web and radio version of this story, we said the Venice Family Clinic is free. In fact it is a community clinic that offers low-cost medical care.

The California Dream Project is a statewide collaboration focused on issues of economic opportunity, quality-of-life, and the future of the California Dream. Partner organizations include CALmatters, Capital Public Radio, KPBS, KPCC, and KQED.

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For Homeless Californians, The Doctor Is Often The ER Street Medicine Aims To Change That - KPBS

Editas Medicine to Participate in Upcoming Investor Conferences – GlobeNewswire

CAMBRIDGE, Mass., Oct. 01, 2019 (GLOBE NEWSWIRE) -- Editas Medicine, Inc. (Nasdaq: EDIT), a leading genome editing company, today announced that management will participate in the following upcoming investor conferences:

Cell & Gene Meeting on the MesaPanel: What does the future hold for gene editing?Date: Friday, October 4, 2019Time: 9:45 a.m. PT

Chardan 3rd Annual Genetic Medicines ConferenceDate: Monday, October 7, 2019

Fireside ChatTime: 10:30 a.m. ET

Panel: Whats next in gene editing technologies?Time: 12:45 p.m. ETLocation: New York, NY

The events will be webcast live and may be accessed on the Editas Medicine website in the Investors and Media section. Archived recordings will be available for approximately 30 days following the events.

About Editas MedicineAs a leading genome editing company, Editas Medicine is focused on translating the power and potential of the CRISPR/Cas9 and CRISPR/Cpf1 (also known as Cas12a) genome editing systems into a robust pipeline of treatments for people living with serious diseases around the world. Editas Medicine aims to discover, develop, manufacture, and commercialize transformative, durable, precision genomic medicines for a broad class of diseases. For the latest information and scientific presentations, please visit http://www.editasmedicine.com.

Contacts:InvestorsMark Mullikin(617) 401-9083mark.mullikin@editasmed.com

MediaCristi Barnett(617) 401-0113 cristi.barnett@editasmed.com

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Editas Medicine to Participate in Upcoming Investor Conferences - GlobeNewswire

American University of the Caribbean School of Medicine Offers Medical School Scholarships to Canadians – Business Wire

PEMBROKE PINES, Fla.--(BUSINESS WIRE)--With an ongoing doctor shortage in Canada, American University of the Caribbean (AUC) School of Medicine is providing scholarships of approximately $73,000 (CAD) per student for Canadians accepted to the university.

Currently, more than 150 Canadian students attend AUC School of Medicine, the overwhelming majority of whom received scholarships totaling more than four million Canadian dollars. Over the past two decades, the school has helped hundreds of Canadians become practicing physicians, many with the help of scholarships.

Our medical students from Canada, whether they choose to study at our campus in Sint Maarten or at our new campus in the U.K., are important assets to our community at AUC School of Medicine. They take advantage of the opportunities for community engagement, and many take on leadership roles within the student body, said Dr. Heidi Chumley, executive dean of AUC School of Medicine. Many wish to return to Canada to practice and help address crucial healthcare workforce and access issues, such as the doctor shortage.

While 15% of Canadians aged 12 and older dont have a regular healthcare provider1, the problem is much worse in in rural regions, which attract just 10% of the nations doctors.2

The AUC School of Medicine Canadian scholarship is available to incoming Canadian students who qualify, and is renewable each semester when the student maintains good academic standing. To learn more visit: aucmed.edu.

About American University of the Caribbean School of Medicine

American University of the Caribbean School of Medicine (AUC School of Medicine) is an institution of Adtalem Global Education (NYSE: ATGE), a global education provider headquartered in the United States. AUC School of Medicines mission is to train tomorrows physicians, whose service to their communities and their patients is enhanced by international learning experiences, a diverse learning community, and an emphasis on social accountability and engagement. Founded in 1978, AUC School of Medicine has more than 7,000 graduates, many of whom work in primary care or underserved areas. Dedicated to developing physicians with a lifelong commitment to patient-centered care, AUC School of Medicine embraces collaboration, inclusion and community service. With a campus in Sint Maarten, affiliated teaching hospitals in the United States and the United Kingdom, and internationally recognized faculty, AUC School of Medicine has a diverse medical education program for todays globally minded physician. For more information visit aucmed.edu, follow AUC School of Medicine on Twitter (@aucmed), Instagram (@aucmed_edu) and Facebook (@aucmed).

About Adtalem Global Education

The purpose of Adtalem Global Education is to empower students to achieve their goals, find success and make inspiring contributions to our global community. Adtalem Global Education Inc. (NYSE: ATGE; member S&P MidCap 400 Index) is a leading workforce solutions provider and the parent organization of Adtalem Educacional do Brasil (IBMEC, Damsio and Wyden institutions), American University of the Caribbean School of Medicine, Association of Certified Anti-Money Laundering Specialists, Becker Professional Education, Chamberlain University, EduPristine, OnCourse Learning, Ross University School of Medicine and Ross University School of Veterinary Medicine. For more information, please visit adtalem.com and follow us on Twitter (@adtalemglobal) and LinkedIn.

1 Statistics Canada, 2018 Data2 Review of family medicine within rural and remote Canada: education, practice, and policy, 2016.

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American University of the Caribbean School of Medicine Offers Medical School Scholarships to Canadians - Business Wire

Durango Diaries to host session on alternative medicine – The Durango Herald

Durango Diaries, the biweekly storyteller series hosted by The Durango Herald, is back Wednesday, as three local health care practitioners share stories about alternative medicine.

The event will be held at 6 p.m. at Durango Public Library, 1900 East Third Ave.

Speakers will include:

Teresa Jantz, owner of Touchpoint Therapy LLC, who has been practicing Reiki for 10 years, including angelic, crystal and animal Reiki, as well as being a master teacher and practitioner. Reiki brings about inner peace, happiness and optimal health for her students and clients.

Sydney Cooley, a licensed acupuncturist. Before becoming a Chinese medicine practitioner, she worked in criminal justice and with emotionally disturbed adolescents. That work inspired her to help people heal through holistic medicine.

Dr. Nicola Dehlinger, a naturopathic doctor with Pura Vida Natural Healthcare. An expert in the treatment of anxiety, depression and insomnia, she minimizes supplements and medications by empowering her patients to heal themselves.Season 4 of Durango Diaries will continue through November at 6 p.m. Wednesdays at the Durango library. Upcoming event topics are:

Oct. 16: How you can save the environment. Local environmental advocates will share stories about how small movements can grow. Bears Ears advocate Regina Lopez-Whiteskunk, Great Old Broads for the Wilderness Executive Director Shelley Silbert, city of Durango Sustainability Coordinator Imogen Ainsworth and advocate of eco-friendly business practices and Durango Cannabis Co. co-founder Nic Borst will share their stories.

Nov. 6: Photography. Three photographers will share the stories behind their favorite photographs and how they work to create the perfect frame. Storytellers include portrait and wedding photographer Allison Ragsdale, nature photographer Frank Comisar and Herald photographer Jerry McBride.

Nov. 20: Forever young. As our population ages, no one seems to be slowing down. Three retirees who are still pursuing active lifestyles will share their stories. Speakers include National Senior Games swimmer Kathy Kronwall, 82; Pilates instructor Diane Legner, 80; and skiing expert Major Lefebvre, 70.

The podcast of each Durango Diaries, including past seasons, can be heard on iTunes, Spotify or the Heralds website at durangoherald.com/durangodiaries.

To receive the Durango Diaries newsletter, email durangodiaries@durangoherald.com.

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Medicines for the Many – Jacobin magazine

In the UK and across the world, patients are being denied medicines because of a system that prioritizes profits before lives. Labour announced bold policies this week to tackle the immediate crisis in medicines prices as well as transform a fundamentally broken system and re-orientate it to serve public health.

For decades, Big Pharma has decided what medicines get produced and who gets them. They can get away with charging the highest prices because new drugs are awarded twenty-year patents which mean that no other company can make or sell that drug during that period. With no competition, they can charge whatever price they like.

High prices have long been a problem for low and middle income countries but in recent years, prices are so high that rich countries like the UK are also struggling to afford these extortionate rates. Our National Health Service increasingly has to ration or reject effective treatments because they are just too expensive.

Luis Walkerfeatured inJeremy Corbyns speech at the party conference this week. This nine-year-old boy with cystic fibrosis has been campaigning to access a drug called Orkambi, which could slow down the progression of the disease and add years to his life. But the drug isnt available on the NHS in England because it is too expensive.And even after three years of negotiations, the drug maker Vertex is refusing to lower the eye-watering 105,000 price tag.

Sadly, Luis case isnt unique. But it does tell a powerful story about the failings of an innovation system whose products are supposed to support health and well-being. Instead, driven by profit and shareholder value, medicines are produced based on their projected financial returns rather than the priorities of public health. And so, even though we are facing an impending global antibiotics crisis, there has been barely any investment in developing new antibiotics. It is simply an unprofitable venture.

There is also insufficient investment into conditions that affect people living in the Global South, again because these markets are considered not lucrative enough. Pharmaceutical companies spend more on marketing and buying back their own shares than they do in research and development. All of this points to system that does not recognize health as a human right.

In the UK, people treasure the principle of public healthcare for all, free at the point of use, but privatized medicine undermines the values of universality. We desperately need greater public control over medicines to ensure that we have a health innovation system that delivers for public health. And this is exactly what Jeremy Corbyn has announced this week.

The package of measures contained in Medicines for the Many couldnt have come sooner. The proposals include the willingness to use compulsory licensing, a legal mechanism that allows a government to override a patent and permits other companies to produce a medicine at lower prices for the benefit of public health. The World Trade Organization and the World Health Organization recognize that intellectual property rights are not absolute and actively supports governments to use this right to address public health needs. A compulsory license on Orkambi could break the current deadlock and allow Luis and other patients to access this crucial treatment.

And thats just for starters. The public sector plays a significant role in funding research and development. Some estimates say thatbetween one- to two-thirdsof upfront health research globally is funded by the public purse. But there are no safeguards in the system to ensure that medicines developed with public money will benefit the public.

Instead, too often public research is bought up by private companies who go on to develop and market the drugs at high prices. Leaving the public to pay twice, first for the research and then in high prices. Its a classic example of socializing risks while privatizing rewards. As part of the reform package, Labour will include conditions on public funding to ensure that drugs developed with public research are affordable for the NHS.

Finally, Labour is supporting democratic public ownership of drug development and manufacturing capabilities. Manufacturing generic drugs especially those that are in shortage or in areas that are deemed unprofitable will enable future governments to determine and deliver on public health priorities.

This transformative agenda recognizes that access to medicines is crucial to achieving the right to health for all. Its about taking the bold steps to re-orientate the system so that it delivers for public health.

Over many years, the power of Big Pharma has gone largely unchallenged as they have stitched up global rules and constructed for themselves a legal architecture of intellectual property rights and market exclusivities to protect their profits at the expense of patients. Now its time for the pendulum to swing the other way and it looks like Labour will lead the way to start building a pharmaceutical system where saving lives is the priority.

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Medicines for the Many - Jacobin magazine

New England Journal of Medicine publishes data showing improved survival with Jevtana (cabazitaxel) over second androgen receptor-targeted agent in…

PARIS, Sept. 30, 2019 /PRNewswire/ --Data published today in the New England Journal of Medicine showed that patients with metastatic castration-resistant prostate cancer (mCRPC) previously treated with docetaxel and who progressed within 12 months on an androgen receptor (AR)-targeted agent (abiraterone or enzalutamide) experienced significantly longer radiographic progression free survival (rPFS) with Jevtana (cabazitaxel) plus prednisone compared with abiraterone plus prednisone or enzalutamide. Overall survival (OS) with Jevtanawas also significantly longer. These findings from the CARD study were presented today in the Presidential Symposium of the 2019 European Society of Medical Oncology (ESMO) Congress in Barcelona, Spain.

"In this study, treatment with Jevtana significantly improved radiographic progression free survival and overall survival compared with enzalutamide or abiraterone," said Professor Ronald de Wit from Erasmus MC University Hospital, Rotterdam, The Netherlands, and the lead investigator of the CARD study."These results are exciting as they have the potential to impact treatment guidelines for metastatic prostate cancer and current clinical practice."

CARD is a randomized, open-label, treatment sequencing clinical study involving 62 sites across 13 European countries, enrolling 255 patients (median aged 70 years, 31% aged over 75 years) with mCRPC who were previously treated with docetaxel and who progressed within 12 months on an AR-targeted agent,in any order. These patients were randomized 1:1 to Jevtana (25 mg/m2 intravenously every three weeks, daily prednisone, and granulocyte colony-stimulating factor) versus abiraterone (1,000 mg plus prednisone, daily) or enzalutamide (160 mg daily; patients received abiraterone if they were previously treated with enzalutamide, or enzalutamide if they were previously treated with abiraterone).

CARD study met primary and secondary endpoints

The study's primary endpoint was rPFS, which more than doubled with Jevtana treatment (N=129) compared to abiraterone or enzalutamide (N=126; median 8.0 vs 3.7 months; HR=0.54; 95% CI,0.400.73; p<0.0001). Patients treated with Jevtana experienced an improvement in rPFS in all pre-specified subgroups, irrespective of the timing of the previous alternative AR-targeted agent, before or after docetaxel. Jevtana also significantly improved a key secondary endpoint, OS (median 13.6 vs 11.0 months; HR=0.64; 95%CI, 0.460.89; p=0.0078), reducing the risk of death from any cause by 36% compared with abiraterone or enzalutamide. Other key secondary endpoints all favored Jevtana: progression-free survival (PFS) (median 4.4 vs 2.7 months; p<0.0001); confirmed prostate specific antigen (PSA) (35.7% vs 13.5%; p=0.0002) and tumor responses (36.5% vs 11.5%; p=0.004). Pain response (45.0% vs 19.3%; p<0.0001) and time to symptomatic skeletal events (not reached vs 16.7 months, p=0.0499) were also significantly improved with Jevtana treatment.

The incidence of grade 3 adverse events was (56.3% with Jevtana vs 52.4% with AR-targeted agents). Key grade 3 treatment-emergent adverse events with Jevtana versus AR-targeted agents were renal disorders (3.2% vs 8.1%), infections (7.9% vs 7.3%), musculoskeletal pain/discomfort (1.6% vs 5.6%), cardiac disorders (0.8% vs 4.8%), asthenic conditions (4.0% vs 2.4%), diarrhea (3.2% vs 0), peripheral neuropathy (3.2% vs 0) and febrile neutropenia (3.2% vs 0). Serious adverse event rates of any grade were similar for Jevtana treatment (38.9%) and treatment with an AR-targeted agent (38.7%). AEs led to death in 7 vs 14 patients (5.6% vs 11.3%) for Jevtana compared to AR-targeted agents. No new safety signals were observed.

About Prostate Cancer

Prostate cancer is a very heterogenous disease and one of the most common types of cancer in men.1 Prostate cancer is the second leading cause of cancer related death among men in the United States2 and the third in Europe.3

Metastatic castration-resistant prostate cancer (mCRPC) is prostate cancer that has spread beyond the prostate gland and progressed despite androgen deprivation therapy.

About Jevtana (cabazitaxel)

Jevtana is a semi-synthetic taxane chemotherapy. Jevtana is a microtubule inhibitor that binds to tubulin. This leads to the stabilization of microtubules, which results in the inhibition of mitotic and interphase cellular functions.

U.S. INDICATION

JEVTANA is a prescription anti-cancer medicine used with the steroid medicine prednisone. JEVTANA is used to treat men with castration-resistant prostate cancer (prostate cancer that is resistant to medical or surgical treatments that lower testosterone) that has worsened (progressed) after treatment with other medicines, including docetaxel.

IMPORTANT SAFETY INFORMATION FOR U.S. PATIENTS

What is the most important information I should know about JEVTANA?

JEVTANA may cause serious side effects, including:

Low white blood cells,which can cause you to get serious infections, and may lead to death. Men who are 65 years or older may be more likely to have these problems. Yourhealthcareprovider (HCP):

Tell your HCP right away if you have any of these symptoms of infection during treatment with JEVTANA:fever (take your temperature often during treatment with JEVTANA), cough, burning during urination, or muscle aches.

Also, tell your HCP if you have any diarrhea during the time that your white blood cell count is low. Your HCP may prescribe treatment for you as needed.

Severe allergic reactionscan happen within a few minutes after your infusion of JEVTANA starts, especially during the first and second infusions. Your HCP should prescribe medicines before each infusion to help prevent severe allergic reactions.

Tell your HCP right away if you have any of these symptoms of a severe allergic reaction during or soon after an infusion of JEVTANA:rash or itching, skin redness, feeling dizzy or faint, breathing problems, chest or throat tightness, or swelling of face.

JEVTANA can cause severe stomach and intestine problems, which may lead to death. You may need to go to the hospital for treatment.

Vomiting and diarrhea can happen when you receive JEVTANA. Severe vomiting and diarrhea with JEVTANA can lead to loss of too much body fluid (dehydration), or too much of your body salts (electrolytes). Death has happened from having severe diarrhea and losing too much body fluid or body salts with JEVTANA. Your HCP will prescribe medicines to prevent or treat vomiting and diarrhea, as needed with JEVTANA.

Tell your HCP if:you have vomiting or diarrhea, or if your symptoms get worse or do not get better. JEVTANA can cause a leak in the stomach or intestine, intestinal blockage, infection, and bleeding in the stomach or intestine. This can lead to death.Tell your HCP if you get any of these symptoms:severe stomach-area (abdomen) pain, constipation, fever, blood in your stool, or changes in the color of your stool.

Kidney failuremay happen with JEVTANA, because of severe infection, loss of too much body fluid (dehydration), and other reasons, which may lead to death. Your HCP will check you for this problem and treat you if needed.

Tell your HCP if you develop these signs or symptoms:swelling of your face or body, or decrease in the amount of urine that your body makes each day or blood in your urine.

Lung or breathing problemsmay happen with JEVTANA and may lead to death. Men who have lung disease before receiving JEVTANA may have a higher risk for developing lung or breathing problems with JEVTANA treatment. Your HCP will check you for this problem and treat you if needed.

Tell your HCP right away if you develop any new or worsening symptoms, including: trouble breathing, shortness of breath, chest pain, cough or fever.

Who should not receive JEVTANA?

Do not receive JEVTANA if:your white blood cell (neutrophil count) is too low, you have had a severe allergic reaction to cabazitaxel or other medicines that contain polysorbate 80 (ask your HCP if you are not sure), you have severe liver problems or you are pregnant. JEVTANA can harm your unborn baby or possibly cause loss of pregnancy.

What should I tell my HCP before receiving JEVTANA?Before receiving JEVTANA, tell your HCP if you:

JEVTANA may cause fertility problems in males. This may affect your ability to father a child. Talk to your HCP if you have concerns about fertility.

Tell your HCP about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. JEVTANA can interact with many other medicines. Do not take any new medicines without asking your HCP first. Your HCP will tell you if it is safe to take the new medicine with JEVTANA.

What are the possible side effects of JEVTANA?

Common side effects of JEVTANA include:

Tell your HCP if you have any side effect that bothers you or that does not go away.These are not all the possible side effects of JEVTANA. For more information, ask your HCP or pharmacist.

Call your doctor for medical advice about side effects. You may report side effects to FDA at1-800-FDA-1088.

Please see fullPrescribing Information/Patient Information, including Serious Side Effects.

About Sanofi

Sanofi is dedicated to supporting people through their health challenges. We are a global biopharmaceutical company focused on human health. We prevent illness with vaccines, provide innovative treatments to fight pain and ease suffering. We stand by the few who suffer from rare diseases and the millions with long-term chronic conditions.

With more than 100,000 people in 100 countries, Sanofi is transforming scientific innovation into healthcare solutions around the globe.

Sanofi, Empowering Life

Media Relations Contact

Investor Relations Contact

Ashleigh Koss

George Grofik

Tel.: +1 908-981-8745

Tel.: +33 (0)1 53 77 45 45

Ashleigh.Koss@sanofi.com

ir@sanofi.com

Sanofi Forward-Looking Statements This press release contains forward-looking statements as defined in the Private Securities Litigation Reform Act of 1995, as amended. Forward-looking statements are statements that are not historical facts. These statements include projections and estimates and their underlying assumptions, statements regarding plans, objectives, intentions and expectations with respect to future financial results, events, operations, services, product development and potential, and statements regarding future performance. Forward-looking statements are generally identified by the words "expects", "anticipates", "believes", "intends", "estimates", "plans" and similar expressions. Although Sanofi's management believes that the expectations reflected in such forward-looking statements are reasonable, investors are cautioned that forward-looking information and statements are subject to various risks and uncertainties, many of which are difficult to predict and generally beyond the control of Sanofi, that could cause actual results and developments to differ materially from those expressed in, or implied or projected by, the forward-looking information and statements. These risks and uncertainties include among other things, the uncertainties inherent in research and development, future clinical data and analysis, including post marketing, decisions by regulatory authorities, such as the FDA or the EMA, regarding whether and when to approve any drug, device or biological application that may be filed for any such product candidates as well as their decisions regarding labelling and other matters that could affect the availability or commercial potential of such product candidates, the absence of guarantee that the product candidates if approved will be commercially successful, the future approval and commercial success of therapeutic alternatives, Sanofi's ability to benefit from external growth opportunities and/or obtain regulatory clearances, risks associated with intellectual property and any related pending or future litigation and the ultimate outcome of such litigation, trends in exchange rates and prevailing interest rates, volatile economic conditions, the impact of cost containment initiatives and subsequent changes thereto, the average number of shares outstanding as well as those discussed or identified in the public filings with the SEC and the AMF made by Sanofi, including those listed under "Risk Factors" and "Cautionary Statement Regarding Forward-Looking Statements" in Sanofi's annual report on Form 20-F for the year ended December 31, 2018. Other than as required by applicable law, Sanofi does not undertake any obligation to update or revise any forward-looking information or statements

1https://www.who.int/en/news-room/fact-sheets/detail/cancer

2Siegel RL, Miller KD, Jemal A. Cancer statistics, 2019. CA Cancer J Clin. 2019;69(1):7-34.

3Malvezzi M, Carioli G, Bertuccio P, et al. European cancer mortality predictions for the year 2019 with focus on breast cancer. Ann Oncol. 2019;30(5):781-787

SAUS.CAB.19.09.4971

SOURCE Sanofi

http://www.sanofi.us

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New England Journal of Medicine publishes data showing improved survival with Jevtana (cabazitaxel) over second androgen receptor-targeted agent in...

Take this medicine, and tell me about a day in your life – AAMCNews

A few years ago, I was working as an attending physician on the inpatient floor of Barnes-Jewish Hospital in St. Louis, Missouri. Barnes-Jewish is the teaching hospital for Washington University School of Medicine in St. Louis, and its a wonderful hospital, with highly competent and compassionate doctors, nurses, and other health care professionals.

But treating patients there was hard and often demoralizing, for the patients and for us. Thats because despite all of the tools at our disposal the latest technology, the best medicines, a compassionate and caring staff many patients just werent getting better. They would come in to see us and we would fix their immediate problem, but because of their social circumstances or where they lived or worked or limitations in their access to healthy food or affordable medications, they kept returning again and again.

I remember one patient, a 50-year-old woman with Type 2 diabetes who kept being readmitted to the hospital because her sugars were too high. She knew and we knew that a healthy diet and regular exercise would help her better control her blood sugar and reduce the amount of medication she needed. But she lived in a part of the city that was plagued by gun violence. Furthermore, she had no local grocery stores and got most of her food from a nearby 7-Eleven. She also worked two jobs, so she had no time to cook, shop for healthier foods, or exercise.

Those were the circumstances of her life, and they negatively affected the course of her disease.

As a physician, when your patients keep coming back to the hospital again and again, it can be frustrating. But understanding why they keep coming back can make you a better doctor.

I remember another patient, a man in his 60s with congestive heart failure, who often failed to show up for his regular appointments. When he got too sick, he would come to the emergency room. Turns out that this patient lived independently but had no car, so he would have to take three buses to get to the clinic. He had severe arthritis, so his mobility was even further limited. He often cut back on his medications, thinking that if he just took half his dose, he might be able to stretch out the interval between clinic visits. When he shared this information, it allowed the social worker to better connect him with community resources and help him make his appointments.

As a physician, when your patients keep coming back to the hospital again and again, it can be frustrating. But understanding why they keep coming back the social determinants that cause them to miss appointments or cut their medications in half or struggle to eat better and exercise more can make you a better doctor.

On Sept. 12, Stanley Goldfarb, MD, former associate dean of curriculum at the Perelman School of Medicine at the University of Pennsylvania, wrote an opinion piece for the Wall Street Journal lamenting medical schools incorporation of social justice issues in medical education. Goldfarb stated, incorrectly, that medical schools teach about social inequities, gun violence, climate change, and bias at the expense of rigorous scientific knowledge about the underpinnings and treatment of disease.

This is just not true. I have had the privilege of visiting medical schools and talking with medical educators around the country. Our educators are teaching the foundational sciences, they are teaching the social determinants of health, they are teaching how to communicate with diverse patients. They are doing all of this well, and they continually strive to do it all better.

A more diverse and culturally responsive physician workforce, and an understanding of the behavioral, psychological, and social determinants of health, are critically important to educating not only good but great physicians.

As medical educators, our responsibility is to teach future physicians to provide the best possible care for their patients and to improve the health of all. This means making sure they have the medical and scientific knowledge they need, as well as an understanding of environmental and social factors that affect a patients health. To suggest that medical education cannot or should not do both creates a false dichotomy.

Medical education has advanced to keep pace with rapid developments in medicine and science. We also know our patients health is inextricably linked to their environments, their communities, and the social fabrics of their lives. A more diverse and culturally responsive physician workforce, and an understanding of the behavioral, psychological, and social determinants of health, are critically important to educating not only good but great physicians.

So, too, is the ability of doctors to listen to, and communicate with, their patients. As new doctors avow in the Hippocratic Oath, I will remember that there is an art to medicine as well as science, and that warmth, sympathy, and understanding may outweigh the surgeons knife or the chemists drug.

Our profession is grounded in the human interaction between doctor and patient. The next generation of physicians must have not just the comprehensive skills and knowledge needed to care for their patients, but the ability to understand and empathize with them.Our patients deserve this, our learners want this, and our educators are working hard to meet these needs.

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Take this medicine, and tell me about a day in your life - AAMCNews

Woman says her medicine is being taken away with vaping ban – WCVB Boston

A Massachusetts woman says the statewide vaping ban will severely affect her ability to function.Felicia Sagner has had severe, debilitating pain and migraines since she was involved in a car crash four years ago.The wife and mother of two said the pain was so paralyzing, she was practically stuck on her couch for two years. She struggled to find a form of treatment that eased it until she tried vaping medical marijuana."Things like CBD and THC, when used properly, can cure anything from a little sleeplessness to severe migraine pain," Sagner said."All of a sudden, I had my wife back -- for the first time in two years," said her husband, Daniel Sagner.When state officials banned all vaping products in Massachusetts on Tuesday, including THC, the Sagners stocked up. However, Felicia Sagner fears that her personal cure may vanish."How dare you," she said. "This was my medicine."The temporary ban came after a growing number of mysterious illnesses in America, including 805 lung injuries and 12 deaths across 10 states, were linked to vaping. Health officials said 77% of those patients had vaped THC before they exhibited symptoms.The Massachusetts vaping ban is a tough outcome for those like Felicia Sagner who vape medical marijuana, but Gov. Charlie Baker believes the health risks associated with vaping are too high at this time to continue to allow it.He declared a public health emergency, which temporarily banned the sale of all vaping products in the state for the next four months."In this particular case, until we know more about the short-term impact of vaping on certain people, I don't consider it to be a safe alternative," Baker said.Sagner, however, believes vaping is safer for her children when it comes to secondhand smoke and says vaping lets her control her dosage."You get exactly what you need when you need it," she said. "If you ingest an edible, it usually kind of hits you when you're least expecting it."Baker thinks four months is enough time for doctors to determine what's making people sick, but Sagner hopes answers to the health crisis come sooner than that."What he banned was the vape oil, which gave me the freedom to be a mother," she said.

A Massachusetts woman says the statewide vaping ban will severely affect her ability to function.

Felicia Sagner has had severe, debilitating pain and migraines since she was involved in a car crash four years ago.

The wife and mother of two said the pain was so paralyzing, she was practically stuck on her couch for two years. She struggled to find a form of treatment that eased it until she tried vaping medical marijuana.

"Things like CBD and THC, when used properly, can cure anything from a little sleeplessness to severe migraine pain," Sagner said.

"All of a sudden, I had my wife back -- for the first time in two years," said her husband, Daniel Sagner.

When state officials banned all vaping products in Massachusetts on Tuesday, including THC, the Sagners stocked up. However, Felicia Sagner fears that her personal cure may vanish.

"How dare you," she said. "This was my medicine."

The temporary ban came after a growing number of mysterious illnesses in America, including 805 lung injuries and 12 deaths across 10 states, were linked to vaping. Health officials said 77% of those patients had vaped THC before they exhibited symptoms.

The Massachusetts vaping ban is a tough outcome for those like Felicia Sagner who vape medical marijuana, but Gov. Charlie Baker believes the health risks associated with vaping are too high at this time to continue to allow it.

He declared a public health emergency, which temporarily banned the sale of all vaping products in the state for the next four months.

"In this particular case, until we know more about the short-term impact of vaping on certain people, I don't consider it to be a safe alternative," Baker said.

Sagner, however, believes vaping is safer for her children when it comes to secondhand smoke and says vaping lets her control her dosage.

"You get exactly what you need when you need it," she said. "If you ingest an edible, it usually kind of hits you when you're least expecting it."

Baker thinks four months is enough time for doctors to determine what's making people sick, but Sagner hopes answers to the health crisis come sooner than that.

"What he banned was the vape oil, which gave me the freedom to be a mother," she said.

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Woman says her medicine is being taken away with vaping ban - WCVB Boston

New UCI study explains the molecular mechanism of botanical folk medicines used to treat hypertension – Newswise

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Proceedings of the National Academy of Sciences (PNAS)

Newswise Irvine, Calif. September 30, 2019 Common herbs, including lavender, fennel and chamomile, have a long history of use as folk medicines used to lower blood pressure. In a new study, University of California, Irvine researchers explain the molecular mechanisms that make them work.

Published today in Proceedings of the National Academy of Sciences (PNAS), the study illustrates how many of the known traditional botanical plants used to lower blood pressure activate a specific potassium channel (KCNQ5) in blood vessels. KCNQ5, together with other potassium channels including KCNQ1 and KCNQ4, is expressed in vascular smooth muscle. When activated, KCNQ5 relaxes blood vessels, making it a logical mechanism for at least part of the hypotensive actions of certain botanical folk medicines.

We found KCNQ5 activation to be a unifying molecular mechanism shared by a diverse range of botanical hypotensive folk medicines. Lavandula angustifolia, commonly called lavender, was among those we studied. We discovered it to be among the most efficacious KCNQ5 potassium channel activators, along with fennel seed extract and chamomile, said Geoff Abbott, PhD, professor of physiology and biophysics at the UCI School of Medicine and senior investigator on the study.

Interestingly, the KCNQ5-selective potassium channel activation feature found in the botanicals is lacking in the modern synthetic pharmacopeia. Until now, it seems to have eluded conventional screening methods utilizing chemical libraries, which may account for why it is not a recognized feature of synthetic blood pressure medications.

Our discovery of these botanical KCNQ5-selective potassium channel openers may enable development of future targeted therapies for diseases including hypertension and KCNQ5 loss-of-function encephalopathy, said Abbott.

Documented use of botanical folk medicines stretches back as far as recorded human history. There is DNA evidence, dating back 48,000 years, that suggests the consumption of plants for medicinal use by Homo neanderthalensis. Archaeological evidence, dating back 800,000 years, even suggests non-food usage of plants by Homo erectus or similar species. Today, evidence of the efficacy of botanical folk medicines ranges from anecdotal to clinical trials, however the underlying molecular mechanisms often remain elusive.

This study was supported by the National Institutes of Health, National Institute of General Medical Sciences and the National Institute of Neurological Disorders and Stroke. Also involved in the study were UCIs Ran Manville, PhD, PhD student Kaitlyn Redford and Benjamin Katz, PhD, and from the University of Copenhagen, Denmark, PhD student Jennifer van der Horst and Thomas Jepps, PhD.

About the UCI School of Medicine: Each year, the UCI School of Medicine educates more than 400 medical students, as well as 200 doctoral and masters students. More than 600 residents and fellows are trained at UC Irvine Medical Center and affiliated institutions. The School of Medicine offers an MD; a dual MD/PhD medical scientist training program; and PhDs and masters degrees in anatomy and neurobiology, biomedical sciences, genetic counseling, epidemiology, environmental health sciences, pathology, pharmacology, physiology and biophysics, and translational sciences. Medical students also may pursue an MD/MBA, an MD/masters in public health, or an MD/masters degree through one of three mission-based programs: the Health Education to Advance Leaders in Integrative Medicine (HEAL-IM), the Leadership Education to Advance Diversity-African, Black and Caribbean (LEAD-ABC), and the Program in Medical Education for the Latino Community (PRIME-LC). The UCI School of Medicine is accredited by the Liaison Committee on Medical Accreditation and ranks among the top 50 nationwide for research. For more information, visit som.uci.edu.

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New UCI study explains the molecular mechanism of botanical folk medicines used to treat hypertension - Newswise

10 Things Nurses Would Never Keep In Their Medicine Cabinets – HuffPost

Some items in your medicine cabinet are staples that belong there, like a first aid kit, tweezers and eye drops. But are there some items that shouldnt be stored in your bathroom cupboard?

Medical experts say yes. We surveyed nurses to get their take on what they would never keep in their own medicine cabinets and why you shouldnt either. Their answers may surprise you.

1. Makeup thats beyond its expiration date

Caiaimage/Tom Merton via Getty Images

Repeated use of expired makeup, especially foundation and eyeliners, can cause infection, said Sandy Cayo, a clinical assistant professor of nursing at New York Universitys Rory Meyers College of Nursing. She added that with every use of expired makeup, you increase the chances of bacterial growth and in turn breakouts and infections.

Your makeup products should have an expiration date listed on the packaging, but in the event that they dont, here is a rough guideline as to how long things should last:

2. Narcotics

Any drug that you dont want into the hands of kids or home guests should be stored somewhere more secure than a medicine cabinet, said Teri Dreher, a registered nurse and owner of NShore Patient Advocates in Chicago.

Dreher said narcotics, in particular, should be under lock and key, or safely hidden. (Examples of these include medications like codeine and oxycodone.) And when theyre no longer needed, they should be disposed of at special boxes at pharmacies or police stations.

There is a nationwide opioid epidemic and you can never be more careful that narcotics do not end up in the wrong hands, Dreher explained.

Its also a good idea to get rid of any narcotics that are expired and you no longer need. If you have been treated for an injury or a surgery and were prescribed narcotics but didnt use them all, they should be properly disposed, explained Ashley Cook, the patient safety manager at Avista Adventist Hospital in Louisville Colorado.

3. Medications

Not storing your medications in a medicine cabinet may sound counterintuitive, but Gail Trauco, a patient advocate and CEO of medical retail store The PharmaKon LLC in Atlanta, doesnt recommend keeping them there.

All medications have [expiration] dates and temperature storage requirements, Trauco said, adding that it can be challenging to read whats on labels as they fade in a medicine cabinet.

Crystal Polson, a nurse practitioner and founder of patient advocacy blog Prudent Patient, pointed out that bathroom conditions can degrade whats outside and inside medicine containers. Many medications are sensitive to heat and moisture from your shower, bath or sink. They can break down from the humidity or become less potent due to the change in temperature, she said.

Polson said its best to store your medications in a cool, dry place. If there are young children around, be sure to keep drugs in a locked box or cabinet, she added.

4. Retinol and vitamin C-based products

Skin care products that contain retinol should never be stored in a medicine cabinet, Trauco said. Light, air and heat alter the chemical structure of retinol, limiting its efficacy. And the same goes with vitamin C-infused products.

Skin care products filled with vitamin C are very popular, Trauco said. Unfortunately, heat reduces its potency, so store those serums and moisturizers someplace else, away from heat and light.

5. Emergency medications

Tiffany Parker, an emergency nurse in Jacksonville, North Carolina, said to keep the following out of your medicine cabinet: EpiPens, sublingual nitroglycerine tablets, rescue inhalers, insulin, glucose tablets, and blood glucose level measuring supplies for diabetics.

Those should never be left in the medicine cabinet because there is a potential to forget and leave the house without them, Parker explained.

She recommended keeping these items in a purse or an easily carried go bag so you are never without these lifesaving supplies. (Just dont leave them in a hot car or somewhere that puts them at risk.)

6. Your toothbrush

5second via Getty Images

Kathy Frerk, a registered nurse in Sioux Falls, South Dakota, explained that a cabinet can hoard the heat and humidity of your bathroom, allowing harmful organisms to grow. That can be bad news for a device that you then stick in your mouth.

After using, store your toothbrush standing upright so it can air dry and not harbor moisture, Frerk said. And to cut down on gum disease, Frerk also recommended soaking your toothbrush in Listerine to kill bacteria. And dont forget to replace your toothbrush every three months.

7. Used razor blades

How many times have you tossed your razor into your medicine cabinet, then pulled it out later to reuse over and over for longer than you should?

An old blade and irritated skin is a dangerous combination and just because you dont see the cuts on your skin doesnt mean theyre not there, Cayo said. She added that this is because a worn-out blade can cause microscopic tears in your skin and introduce bacteria, which in turn can increase the risk for infection.

Some tips for helping to keep your razor blade clean include rinsing it with warm water between strokes to remove hair clogging it, towel drying it once you finish shaving, and allowing it to air out when you store it. (Avoid closed-off cabinets.) Experts also suggest replacing a disposable razor blade after every five to 10 uses, and refraining from sharing one with a friend or family member.

8. Gummy vitamins

This is more of an access issue. Gummy vitamins taste like candy, and you dont want kids going into the medicine cabinet looking for them, Parker explained. Medicine cabinets are easy to get into for young children, and they may take it upon themselves to eat the vitamins when theyre not under supervision. And ingesting too many vitamins can be extremely toxic, Parker said. She recommended storing them out of a kids reach and with a childproof lid.

9. Hydrogen peroxide or rubbing alcohol

Jummie via Getty Images

This is something Polson said she generally avoids keeping around in her bathroom, medicine cabinet or otherwise.

Why? Contrary to popular belief, these two agents are not appropriate for cleaning minor cuts and scrapes. In fact, they can both harm skin tissue and delay wound healing, Polson said.

She added that the best way to take care of a minor injury is with clean water and mild soap. Sticking your cut under cool water, gently lathering up, and rinsing it for five minutes can do the job of removing any debris, bacteria and dirt. And an emergency physician should handle larger or deeper cuts.

10. Liquid bandage

This specific product is not something that Catherine Burger, a registered nurse and media specialist for RegisteredNursing.org, recommended having in your medicine cabinets first aid kit. While a liquid bandage-based product can work on cuts if administered correctly, its often not applied well at home in a hurry.

We have had to pick these products out of too many infected wounds. Plus, the products can be very painful for superficial cuts, Burger explained.

They also have an array of potential side effects, including hives, itching, skin redness and a stinging sensation. Best to stick with regular bandages if youre unsure.

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10 Things Nurses Would Never Keep In Their Medicine Cabinets - HuffPost

Joseline Hernandez Made Her Married To Medicine Debut This Week And Already Has An Enemy – BET

Joseline Hernandez's Love & Hip Hop days may be over, but the reality TV icon isn't done shaking the table just yet. To prove that, she is set to make her debut on Bravo's Married to Medicine on Sunday, September 29, and judging from a preview clip of the episode, she wasted no time stirring the pot.

In a clip from the upcoming episode, the self-proclaimed Puerto Rican princess is seen getting into it with OG cast memberToya Bush-Harrisover their views on mothering.

"I call it being a mother, I don't think it's a job," Hernandez said, to which Bush-Harris rebutted, "Being a mother is a full-time job."

The Love & Hip Hop star then took their seemingly civilized disagreement to new heights when she used Bush-Harris' reported tax woes as ammunition.

"But, you know, we're gonna keep letting you live it up, not paying your taxes," she said.

Take a look at the brief preview, below:

For those confused about Hernandez's random appearance on the hit Bravo reality series, she was brought on as a friend toMarried to Medicine newcomer Buffie Purselle, a personal finance and tax professional and the wife of well-known psychiatrist Dr. David Purselle.

In response to the shady clip, she claimed she only took such a sharp approach because Harris came for Purselle first.

"Don't come for my sister @BuffiePurselle or you will get the business," she tweeted.

There's never a dull moment with this lady, no matter where she goes.

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Joseline Hernandez Made Her Married To Medicine Debut This Week And Already Has An Enemy - BET

Married To Medicine Recap: Ballin On A Budget – Reality Tea

On last nights episode of Married to Medicine, there was a little bit of everything. You have reconciliations, budgets and of course some drama. Im starting to think its weird when there isnt an issue, because its so rare.

Jackie Walters and Curtis have big dreams for their house, but are finding out their budget may be too small for their plans. Contessa Metcalfes family is having a difficult time with her being away in Nashville. Simone Whitmores friend, Buffie throws a party and things go downhill fast with some of the guests. Are we surprised? It wouldnt be a true Married to Medicine episode, without a little shade!

Jackie and Curtis to discuss the renovations they want to be made to their home. They both have very different taste in decor. Curtis thinks some of Jackies choices are too much, including the chandelier in the closet. Jackie is just happy to finally get to work on some of the changes she has wanted for the house. Curtis will just have to deal. He is lucky that they arent in a condo in the city.

Scott Metcalfe and Contessa take the kids to the park for some quality time. Contessa doesnt feel like Scott is as emotionally supportive of the kids as she is. I just think Contessa needs to give poor Scott a break. They are two different parents and arent going to always do things the same way. The kids even admit that they dont like that shes away in school. Her youngest daughter tells Contessa that she sometimes forgets about her when shes not around. Wow that has to hurt.

Buffie decides to throw another end of tax season party. The theme requires everyone to have a $500 limit for their outfits. On the way to the party, Quad Webb-Lunceford discusses Simone withHeavenly Kimes. Meanwhile, Simone talks to Jackie about her issues with Quad. Both ladies think they are owed an apology. When Quad and Simone see each other they agree to work out their problems, despite their recent blowup. Of course,Mariah Huq has to throw a dig when she sees Heavenly. She tells Heavenly that cheap dresses look good on her.

When I saw Joseline Hernandez at this party, I knew nothing good would come of it. Apparently, she has been a client and friend of Buffies for the past 5 years. Joseline clashes with Toya Bush-Harris after she says being a mother is a full-time job. Joseline takes the opportunity to shade Toya about her past tax debt and tell her she looks thrifty. Toya warns Joseline to stay out of her personal business. Mariah has to take Toya to the bathroom to calm her down. Buffie attempts to apologize for Joselines actions. Joseline went off on Eugene Harrisas well. When he told her not to call his wife a hoe, Joseline went off. Frustrated with the drama, Toya and Eugene decide to leave. Well, I cant say Im surprised.

Mariah meets up with Toya to discuss the party. Toya didnt like how Buffie handled the situation with Joseline. At this point, she has no desire to move forward with Buffie. If anyone has seen Joseline on Love and Hip Hop they know, she can be a lot to deal with. I am questioning why Buffie would even think it was a good idea to invite her. Nonetheless, Toya is looking forward to her upcoming birthday party.

Toya decides to have a sip and paint event for her 43rd birthday. She even invites Contessa. However, she leaves Buffie off of her invitation list. Look how things have changed. Toya wants to move on from her past issues with Contessa. The two even hug when Contessa arrives. Simone brings Buffie to the party anyway. Toya isnt happy, but Simone hopes she will give Buffie another chance.

At the beginning of the event, Toya reveals that she had a miscarriage. After dealing with the loss, she wanted to have something that was positive. Buffie gives Toya a hug and offers condolences. Then nude male models come out. I guess it wouldnt be Toya if there wasnt a twist to the evening.Heavenly decides not to tell her husband about that part of the night.

Im glad Toya finally told everyone what she has been going through lately. Maybe in the future they will be nicer to one another. You never know what someone else is dealing with personally. I doubt this group will totally mend all their issues, but its nice when they can come together.

TELL US SHOULD CONTESSA PUT HER KIDS DESIRES ABOVE HER OWN? DID BUFFIE HANDLE THE ARGUMENT BETWEEN TOYA AND JOSELINE THE WRONG WAY? DO YOU THINK QUAD AND SIMONES TRUCE WILL LAST? WHAT DID YOU THINK ABOUT LAST NIGHTS MARRIED TO MEDICINE EPISODE?

[Photo Credit: Bravo]

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Married To Medicine Recap: Ballin On A Budget - Reality Tea

Why drug trials are only part of the answer to making sure medicines work – The Conversation – UK

There was a moment when, as a pharmacist, I realised that a lot of people to whom I gave medicine were going to receive little benefit, or even none at all. Healthcare staff make clinical decisions of when to use one medicine or another based upon evidence drawn from clinical trials. Clinical trials give us the data that show the probability that a medicine will have the desired effect but there is also the chance that it will not.

Clinical trials are a good way of identifying drugs that, on the whole, are effective at achieving a specific outcome. But on the whole doesnt take into account the wide variation among humans that means patients may react very differently to the drugs theyre given. The promise of personalised medicine is that through a more accurate understanding of a patients genetic makeup, alongside factors such as their lifestyle, diet and environment, they can be prescribed different drugs depending on what we know about how those drugs will affect them personally, rather than on the whole.

Clinical trial data are based on probabilities. Most controlled trials test a drug against a placebo or an existing drug, and the outcomes such as not having a heart attack, or experiencing a side effect are counted up to compare.

The likelihood that a patient will experience an event is known as absolute risk. This is calculated by dividing the number of events by the number of people. For example, if eight of a group of 100 people have a heart attack in a single year, the absolute risk is 8/100 = 0.08 (or 8%). Say that during a drug trial the absolute risk for those given the drug is 0.03, and for the placebo group it is 0.08, the drug on trial would be said to have achieved an absolute risk reduction of 0.05 (or 5%).

However, there is a risk that people experience an event whether or not they are taking the drug. This relative risk is calculated by dividing the absolute risk of the group taking the drug by the absolute risk of the control group given the placebo. The drugs efficiency taking into account background risk the relative risk reduction is calculated by dividing the absolute risk reduction by the absolute risk of the placebo group. Using the same example above, it would be 0.05/0.08, or 0.625 (or 62.5%).

Crucially, if you are in the business of manufacturing and selling medicines, expressing a drugs effectiveness by its relative risk reduction offers a better impression than by its absolute risk: lets face it, a reduction of 62.5% sounds much more impressive than a reduction of 5%.

Read more: Personalised medicine: how science is using the genetics of disease to make drugs better

Using these methods on clinical trial data help us gauge the effectiveness of medicines, but they dont take into account the differences among the patients taking them. Through genetic variation, human bodies vary considerably in the way they interact with drugs, potentially making them more effective, less effective, or something else entirely. For example, people with high cholesterol, something that runs in families, are in the UK currently offered DNA testing to confirm their diagnosis, and start treatment much earlier.

To see how much these factors affect how medicines work: an estimate of the number of people that must take a drug for one person to get the desired outcome is known as the number needed to treat. Using the same example of a drug trial with an absolute risk reduction of 0.05 (5%), this means that, statistically, 20 people (20x5%=100%) would need to be given the drug for one to feel the benefits. As we dont know which of the 20 will benefit from taking the drug, we must give it to all of them.

This is a problem because medicines are not without harms: almost all have side effects, which the other 19 may suffer even without experiencing the drugs benefits. This is known as number needed to harm, where harm could be anything from headaches and rashes to internal bleeding or even death. Clearly, if taking a medicine you would want to know that the benefit outweighs the harm.

Read more: Why I donated my entire genome sequence to the public

As an example, statins are drugs commonly used to lower cholesterol and reduce the risk of having heart attacks and strokes. The drug will reduce the relative risk of heart attack or stroke by about 25%, but may also generate side effects. The patient and prescriber need to balance the benefit versus the harm. This decision can be guided using patient decision aids, developed to help patients understand the balance of benefits and harms in the context of how they may have to change their lifestyle while taking the medicine.

There has been interest in a recent trial of the polypill, a tablet containing blood pressure-lowering medicine and a statin, which was given to around 3,400 people over the age of 50 in Golestan province, Iran. At a population level it led to a reduction in cardiovascular events, but the same approach will also mean more people will experience side effects compared to an approach that targets only those at high risk. In low and middle-income countries that lack the resources to diagnose and target many individuals, this may be a price worth paying.

Which brings us back to the promise of personalised medicine: ideally we would be able to identify the hypothetical one in 20 patients given a drug that benefit from it, and prescribe the medicine to them alone. Beyond the benefit to the patient, there are cost benefits to the health service and to society, but chiefly there are benefits for the other 19 who need not take a drug that wont benefit them and may cause them side effects or adverse drug interactions. Better understanding of our genome and how it affects our risk of disease will provide the tools to identify those most at risk, and target them alone.

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Why drug trials are only part of the answer to making sure medicines work - The Conversation - UK

My Medicine – WebMD

WebMD My Medicine Help

Q: What is an interaction?

A: Mixing certain medicines together may cause a bad reaction. This is called an interaction. For example, one medicine may cause side effects that create problems with other medicines. Or one medicine may make another medicine stronger or weaker.

Q: How do you classify the seriousness of an interaction?

A: The following classification is used:

Contraindicated: Never use this combination of drugs because of high risk for dangerous interaction

Serious: Potential for serious interaction; regular monitoring by your doctor required or alternate medication may be needed

Significant: Potential for significant interaction (monitoring by your doctor is likely required)

Mild: Interaction is unlikely, minor, or nonsignificant

Q: What should I do if my medications show interactions?

A: Call your doctor or pharmacist if you are concerned about an interaction. Do not stop taking any prescribed medication without your doctor's approval. Sometimes the risk of not taking the medication outweighs the risk or the interaction.

Q: Why can't I enter my medication?

A: There may be medications, especially otc or supplements, that have not been adequately studied for interactions. If we do not have interaction information for a certain medication it can't be saved in My Medicine.

Q: Do you cover all FDA warnings?

A: WebMD will alert users to the most important FDA warnings and alerts affecting consumers such as recalls, label changes and investigations. Not all FDA actions are included. Go to the FDA for a comprehensive list of warnings.

Q: Can I be alerted by email if there is an FDA warning or alert?

A: Yes. If you are signed in to WebMD.com and using My Medicine you can sign up to receive email alerts when you add a medicine. To unsubscribe click here.

Q: Can I add medicines for family members?

A: Yes. Click the arrow next to your picture to add drug profiles for family or loved ones.

Q: Can I access My Medicine from my mobile phone?

A: Yes. Sign in to the WebMD Mobile App. Your saved medicine can be found under "Saved."

Q: Why are there already medicines saved when this my first time using this tool?

A: If you have previously saved a medication on WebMD, for example, in the WebMD Mobile App, these may display in My Medicine.

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My Medicine - WebMD

Medicine | Define Medicine at Dictionary.com

c.1200, "medical treatment, cure, remedy," also used figuratively, of spiritual remedies, from Old French medecine (Modern French mdicine) "medicine, art of healing, cure, treatment, potion," from Latin medicina "the healing art, medicine; a remedy," also used figuratively, perhaps originally ars medicina "the medical art," from fem. of medicinus (adj.) "of a doctor," from medicus "a physician" (see medical); though OED finds evidence for this is wanting. Meaning "a medicinal potion or plaster" in English is mid-14c.

To take (one's) medicine "submit to something disagreeable" is first recorded 1865. North American Indian medicine-man "shaman" is first attested 1801, from American Indian adoption of the word medicine in sense of "magical influence." The U.S.-Canadian boundary they called Medicine Line (first attested 1910), because it conferred a kind of magic protection: punishment for crimes committed on one side of it could be avoided by crossing over to the other. Medicine show "traveling show meant to attract a crowd so patent medicine can be sold to them" is American English, 1938. Medicine ball "stuffed leather ball used for exercise" is from 1889.

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Medicine | Define Medicine at Dictionary.com

medicine | Definition, Fields, Research, & Facts | Britannica.com

Organization of health services

It is generally the goal of most countries to have their health services organized in such a way to ensure that individuals, families, and communities obtain the maximum benefit from current knowledge and technology available for the promotion, maintenance, and restoration of health. In order to play their part in this process, governments and other agencies are faced with numerous tasks, including the following: (1) They must obtain as much information as is possible on the size, extent, and urgency of their needs; without accurate information, planning can be misdirected. (2) These needs must then be revised against the resources likely to be available in terms of money, manpower, and materials; developing countries may well require external aid to supplement their own resources. (3) Based on their assessments, countries then need to determine realistic objectives and draw up plans. (4) Finally, a process of evaluation needs to be built into the program; the lack of reliable information and accurate assessment can lead to confusion, waste, and inefficiency.

Health services of any nature reflect a number of interrelated characteristics, among which the most obvious, but not necessarily the most important from a national point of view, is the curative function; that is to say, caring for those already ill. Others include special services that deal with particular groups (such as children or pregnant women) and with specific needs such as nutrition or immunization; preventive services, the protection of the health both of individuals and of communities; health education; and, as mentioned above, the collection and analysis of information.

In the curative domain there are various forms of medical practice. They may be thought of generally as forming a pyramidal structure, with three tiers representing increasing degrees of specialization and technical sophistication but catering to diminishing numbers of patients as they are filtered out of the system at a lower level. Only those patients who require special attention either for diagnosis or treatment should reach the second (advisory) or third (specialized treatment) tiers where the cost per item of service becomes increasingly higher. The first level represents primary health care, or first contact care, at which patients have their initial contact with the health-care system.

Primary health care is an integral part of a countrys health maintenance system, of which it forms the largest and most important part. As described in the declaration of Alma-Ata, primary health care should be based on practical, scientifically sound and socially acceptable methods and technology made universally accessible to individuals and families in the community through their full participation and at a cost that the community and country can afford to maintain at every stage of their development. Primary health care in the developed countries is usually the province of a medically qualified physician; in the developing countries first contact care is often provided by nonmedically qualified personnel.

The vast majority of patients can be fully dealt with at the primary level. Those who cannot are referred to the second tier (secondary health care, or the referral services) for the opinion of a consultant with specialized knowledge or for X-ray examinations and special tests. Secondary health care often requires the technology offered by a local or regional hospital. Increasingly, however, the radiological and laboratory services provided by hospitals are available directly to the family doctor, thus improving his service to patients and increasing its range. The third tier of health care, employing specialist services, is offered by institutions such as teaching hospitals and units devoted to the care of particular groupswomen, children, patients with mental disorders, and so on. The dramatic differences in the cost of treatment at the various levels is a matter of particular importance in developing countries, where the cost of treatment for patients at the primary health-care level is usually only a small fraction of that at the third level; medical costs at any level in such countries, however, are usually borne by the government.

Ideally, provision of health care at all levels will be available to all patients; such health care may be said to be universal. The well-off, both in relatively wealthy industrialized countries and in the poorer developing world, may be able to get medical attention from sources they prefer and can pay for in the private sector. The vast majority of people in most countries, however, are dependent in various ways upon health services provided by the state, to which they may contribute comparatively little or, in the case of poor countries, nothing at all.

The costs to national economics of providing health care are considerable and have been growing at a rapidly increasing rate, especially in countries such as the United States, Germany, and Sweden; the rise in Britain has been less rapid. This trend has been the cause of major concerns in both developed and developing countries. Some of this concern is based upon the lack of any consistent evidence to show that more spending on health care produces better health. There is a movement in developing countries to replace the type of organization of health-care services that evolved during European colonial times with some less expensive, and for them, more appropriate, health-care system.

In the industrialized world the growing cost of health services has caused both private and public health-care delivery systems to question current policies and to seek more economical methods of achieving their goals. Despite expenditures, health services are not always used effectively by those who need them, and results can vary widely from community to community. In Britain, for example, between 1951 and 1971 the death rate fell by 24 percent in the wealthier sections of the population but by only half that in the most underprivileged sections of society. The achievement of good health is reliant upon more than just the quality of health care. Health entails such factors as good education, safe working conditions, a favourable environment, amenities in the home, well-integrated social services, and reasonable standards of living.

The developing countries differ from one another culturally, socially, and economically, but what they have in common is a low average income per person, with large percentages of their populations living at or below the poverty level. Although most have a small elite class, living mainly in the cities, the largest part of their populations live in rural areas. Urban regions in developing and some developed countries in the mid- and late 20th century have developed pockets of slums, which are growing because of an influx of rural peoples. For lack of even the simplest measures, vast numbers of urban and rural poor die each year of preventable and curable diseases, often associated with poor hygiene and sanitation, impure water supplies, malnutrition, vitamin deficiencies, and chronic preventable infections. The effect of these and other deprivations is reflected by the finding that in the 1980s the life expectancy at birth for men and women was about one-third less in Africa than it was in Europe; similarly, infant mortality in Africa was about eight times greater than in Europe. The extension of primary health-care services is therefore a high priority in the developing countries.

The developing countries themselves, lacking the proper resources, have often been unable to generate or implement the plans necessary to provide required services at the village or urban poor level. It has, however, become clear that the system of health care that is appropriate for one country is often unsuitable for another. Research has established that effective health care is related to the special circumstances of the individual country, its people, culture, ideology, and economic and natural resources.

The rising costs of providing health care have influenced a trend, especially among the developing nations, to promote services that employ less highly trained primary health-care personnel who can be distributed more widely in order to reach the largest possible proportion of the community. The principal medical problems to be dealt with in the developing world include undernutrition, infection, gastrointestinal disorders, and respiratory complaints, which themselves may be the result of poverty, ignorance, and poor hygiene. For the most part, these are easy to identify and to treat. Furthermore, preventive measures are usually simple and cheap. Neither treatment nor prevention requires extensive professional training: in most cases they can be dealt with adequately by the primary health worker, a term that includes all nonprofessional health personnel.

Those concerned with providing health care in the developed countries face a different set of problems. The diseases so prevalent in the Third World have, for the most part, been eliminated or are readily treatable. Many of the adverse environmental conditions and public health hazards have been conquered. Social services of varying degrees of adequacy have been provided. Public funds can be called upon to support the cost of medical care, and there are a variety of private insurance plans available to the consumer. Nevertheless, the funds that a government can devote to health care are limited and the cost of modern medicine continues to increase, thus putting adequate medical services beyond the reach of many. Adding to the expense of modern medical practices is the increasing demand for greater funding of health education and preventive measures specifically directed toward the poor.

In many parts of the world, particularly in developing countries, people get their primary health care, or first-contact care, where available at all, from nonmedically qualified personnel; these cadres of medical auxiliaries are being trained in increasing numbers to meet overwhelming needs among rapidly growing populations. Even among the comparatively wealthy countries of the world, containing in all a much smaller percentage of the worlds population, escalation in the costs of health services and in the cost of training a physician has precipitated some movement toward reappraisal of the role of the medical doctor in the delivery of first-contact care.

In advanced industrial countries, however, it is usually a trained physician who is called upon to provide the first-contact care. The patient seeking first-contact care can go either to a general practitioner or turn directly to a specialist. Which is the wisest choice has become a subject of some controversy. The general practitioner, however, is becoming rather rare in some developed countries. In countries where he does still exist, he is being increasingly observed as an obsolescent figure, because medicine covers an immense, rapidly changing, and complex field of which no physician can possibly master more than a small fraction. The very concept of the general practitioner, it is thus argued, may be absurd.

The obvious alternative to general practice is the direct access of a patient to a specialist. If a patient has problems with vision, he goes to an eye specialist, and if he has a pain in his chest (which he fears is due to his heart), he goes to a heart specialist. One objection to this plan is that the patient often cannot know which organ is responsible for his symptoms, and the most careful physician, after doing many investigations, may remain uncertain as to the cause. Breathlessnessa common symptommay be due to heart disease, to lung disease, to anemia, or to emotional upset. Another common symptom is general malaisefeeling run-down or always tired; others are headache, chronic low backache, rheumatism, abdominal discomfort, poor appetite, and constipation. Some patients may also be overtly anxious or depressed. Among the most subtle medical skills is the ability to assess people with such symptoms and to distinguish between symptoms that are caused predominantly by emotional upset and those that are predominantly of bodily origin. A specialist may be capable of such a general assessment, but, often, with emphasis on his own subject, he fails at this point. The generalist with his broader training is often the better choice for a first diagnosis, with referral to a specialist as the next option.

It is often felt that there are also practical advantages for the patient in having his own doctor, who knows about his background, who has seen him through various illnesses, and who has often looked after his family as well. This personal physician, often a generalist, is in the best position to decide when the patient should be referred to a consultant.

The advantages of general practice and specialization are combined when the physician of first contact is a pediatrician. Although he sees only children and thus acquires a special knowledge of childhood maladies, he remains a generalist who looks at the whole patient. Another combination of general practice and specialization is represented by group practice, the members of which partially or fully specialize. One or more may be general practitioners, and one may be a surgeon, a second an obstetrician, a third a pediatrician, and a fourth an internist. In isolated communities group practice may be a satisfactory compromise, but in urban regions, where nearly everyone can be sent quickly to a hospital, the specialist surgeon working in a fully equipped hospital can usually provide better treatment than a general practitioner surgeon in a small clinic hospital.

Before 1948, general practitioners in Britain settled where they could make a living. Patients fell into two main groups: weekly wage earners, who were compulsorily insured, were on a doctors panel and were given free medical attention (for which the doctor was paid quarterly by the government); most of the remainder paid the doctor a fee for service at the time of the illness. In 1948 the National Health Service began operation. Under its provisions, everyone is entitled to free medical attention with a general practitioner with whom he is registered. Though general practitioners in the National Health Service are not debarred from also having private patients, these must be people who are not registered with them under the National Health Service. Any physician is free to work as a general practitioner entirely independent of the National Health Service, though there are few who do so. Almost the entire population is registered with a National Health Service general practitioner, and the vast majority automatically sees this physician, or one of his partners, when they require medical attention. A few people, mostly wealthy, while registered with a National Health Service general practitioner, regularly see another physician privately; and a few may occasionally seek a private consultation because they are dissatisfied with their National Health Service physician.

A general practitioner under the National Health Service remains an independent contractor, paid by a capitation fee; that is, according to the number of people registered with him. He may work entirely from his own office, and he provides and pays his own receptionist, secretary, and other ancillary staff. Most general practitioners have one or more partners and work more and more in premises built for the purpose. Some of these structures are erected by the physicians themselves, but many are provided by the local authority, the physicians paying rent for using them. Health centres, in which groups of general practitioners work have become common.

In Britain only a small minority of general practitioners can admit patients to a hospital and look after them personally. Most of this minority are in country districts, where, before the days of the National Health Service, there were cottage hospitals run by general practitioners; many of these hospitals continued to function in a similar manner. All general practitioners use such hospital facilities as X-ray departments and laboratories, and many general practitioners work in hospitals in emergency rooms (casualty departments) or as clinical assistants to consultants, or specialists.

General practitioners are spread more evenly over the country than formerly, when there were many in the richer areas and few in the industrial towns. The maximum allowed list of National Health Service patients per doctor is 3,500; the average is about 2,500. Patients have free choice of the physician with whom they register, with the proviso that they cannot be accepted by one who already has a full list and that a physician can refuse to accept them (though such refusals are rare). In remote rural places there may be only one physician within a reasonable distance.

Until the mid-20th century it was not unusual for the doctor in Britain to visit patients in their own homes. A general practitioner might make 15 or 20 such house calls in a day, as well as seeing patients in his office or surgery, often in the evenings. This enabled him to become a family doctor in fact as well as in name. In modern practice, however, a home visit is quite exceptional and is paid only to the severely disabled or seriously ill when other recourses are ruled out. All patients are normally required to go to the doctor.

It has also become unusual for a personal doctor to be available during weekends or holidays. His place may be taken by one of his partners in a group practice, a provision that is reasonably satisfactory. General practitioners, however, may now use one of several commercial deputizing services that employs young doctors to be on call. Although some of these young doctors may be well experienced, patients do not generally appreciate this kind of arrangement.

Whereas in Britain the doctor of first contact is regularly a general practitioner, in the United States the nature of first-contact care is less consistent. General practice in the United States has been in a state of decline in the second half of the 20th century, especially in metropolitan areas. The general practitioner, however, is being replaced to some degree by the growing field of family practice. In 1969 family practice was recognized as a medical specialty after the American Academy of General Practice (now the American Academy of Family Physicians) and the American Medical Association created the American Board of General (now Family) Practice. Since that time the field has become one of the larger medical specialties in the United States. The family physicians were the first group of medical specialists in the United States for whom recertification was required.

There is no national health service, as such, in the United States. Most physicians in the country have traditionally been in some form of private practice, whether seeing patients in their own offices, clinics, medical centres, or another type of facility and regardless of the patients income. Doctors are usually compensated by such state and federally supported agencies as Medicaid (for treating the poor) and Medicare (for treating the elderly); not all doctors, however, accept poor patients. There are also some state-supported clinics and hospitals where the poor and elderly may receive free or low-cost treatment, and some doctors devote a small percentage of their time to treatment of the indigent. Veterans may receive free treatment at Veterans Administration hospitals, and the federal government through its Indian Health Service provides medical services to American Indians and Alaskan natives, sometimes using trained auxiliaries for first-contact care.

In the rural United States first-contact care is likely to come from a generalist. The middle- and upper-income groups living in urban areas, however, have access to a larger number of primary medical care options. Children are often taken to pediatricians, who may oversee the childs health needs until adulthood. Adults frequently make their initial contact with an internist, whose field is mainly that of medical (as opposed to surgical) illnesses; the internist often becomes the family physician. Other adults choose to go directly to physicians with narrower specialties, including dermatologists, allergists, gynecologists, orthopedists, and ophthalmologists.

Patients in the United States may also choose to be treated by doctors of osteopathy. These doctors are fully qualified, but they make up only a small percentage of the countrys physicians. They may also branch off into specialties, but general practice is much more common in their group than among M.D.s.

It used to be more common in the United States for physicians providing primary care to work independently, providing their own equipment and paying their own ancillary staff. In smaller cities they mostly had full hospital privileges, but in larger cities these privileges were more likely to be restricted. Physicians, often sharing the same specialties, are increasingly entering into group associations, where the expenses of office space, staff, and equipment may be shared; such associations may work out of suites of offices, clinics, or medical centres. The increasing competition and risks of private practice have caused many physicians to join Health Maintenance Organizations (HMOs), which provide comprehensive medical care and hospital care on a prepaid basis. The cost savings to patients are considerable, but they must use only the HMO doctors and facilities. HMOs stress preventive medicine and out-patient treatment as opposed to hospitalization as a means of reducing costs, a policy that has caused an increased number of empty hospital beds in the United States.

While the number of doctors per 100,000 population in the United States has been steadily increasing, there has been a trend among physicians toward the use of trained medical personnel to handle some of the basic services normally performed by the doctor. So-called physician extender services are commonly divided into nurse practitioners and physicians assistants, both of whom provide similar ancillary services for the general practitioner or specialist. Such personnel do not replace the doctor. Almost all American physicians have systems for taking each others calls when they become unavailable. House calls in the United States, as in Britain, have become exceedingly rare.

In Russia general practitioners are prevalent in the thinly populated rural areas. Pediatricians deal with children up to about age 15. Internists look after the medical ills of adults, and occupational physicians deal with the workers, sharing care with internists.

Teams of physicians with experience in varying specialties work from polyclinics or outpatient units, where many types of diseases are treated. Small towns usually have one polyclinic to serve all purposes. Large cities commonly have separate polyclinics for children and adults, as well as clinics with specializations such as womens health care, mental illnesses, and sexually transmitted diseases. Polyclinics usually have X-ray apparatus and facilities for examination of tissue specimens, facilities associated with the departments of the district hospital. Beginning in the late 1970s was a trend toward the development of more large, multipurpose treatment centres, first-aid hospitals, and specialized medicine and health care centres.

Home visits have traditionally been common, and much of the physicians time is spent in performing routine checkups for preventive purposes. Some patients in sparsely populated rural areas may be seen first by feldshers (auxiliary health workers), nurses, or midwives who work under the supervision of a polyclinic or hospital physician. The feldsher was once a lower-grade physician in the army or peasant communities, but feldshers are now regarded as paramedical workers.

In Japan, with less rigid legal restriction of the sale of pharmaceuticals than in the West, there was formerly a strong tradition of self-medication and self-treatment. This was modified in 1961 by the institution of health insurance programs that covered a large proportion of the population; there was then a great increase in visits to the outpatient clinics of hospitals and to private clinics and individual physicians.

When Japan shifted from traditional Chinese medicine with the adoption of Western medical practices in the 1870s, Germany became the chief model. As a result of German influence and of their own traditions, Japanese physicians tended to prefer professorial status and scholarly research opportunities at the universities or positions in the national or prefectural hospitals to private practice. There were some pioneering physicians, however, who brought medical care to the ordinary people.

Physicians in Japan have tended to cluster in the urban areas. The Medical Service Law of 1963 was amended to empower the Ministry of Health and Welfare to control the planning and distribution of future public and nonprofit medical facilities, partly to redress the urban-rural imbalance. Meanwhile, mobile services were expanded.

The influx of patients into hospitals and private clinics after the passage of the national health insurance acts of 1961 had, as one effect, a severe reduction in the amount of time available for any one patient. Perhaps in reaction to this situation, there has been a modest resurgence in the popularity of traditional Chinese medicine, with its leisurely interview, its dependence on herbal and other natural medicines, and its other traditional diagnostic and therapeutic practices. The rapid aging of the Japanese population as a result of the sharply decreasing death rate and birth rate has created an urgent need for expanded health care services for the elderly. There has also been an increasing need for centres to treat health problems resulting from environmental causes.

On the continent of Europe there are great differences both within single countries and between countries in the kinds of first-contact medical care. General practice, while declining in Europe as elsewhere, is still rather common even in some large cities, as well as in remote country areas.

In The Netherlands, departments of general practice are administered by general practitioners in all the medical schoolsan exceptional state of affairsand general practice flourishes. In the larger cities of Denmark, general practice on an individual basis is usual and popular, because the physician works only during office hours. In addition, there is a duty doctor service for nights and weekends. In the cities of Sweden, primary care is given by specialists. In the remote regions of northern Sweden, district doctors act as general practitioners to patients spread over huge areas; the district doctors delegate much of their home visiting to nurses.

In France there are still general practitioners, but their number is declining. Many medical practitioners advertise themselves directly to the public as specialists in internal medicine, ophthalmologists, gynecologists, and other kinds of specialists. Even when patients have a general practitioner, they may still go directly to a specialist. Attempts to stem the decline in general practice are being made by the development of group practice and of small rural hospitals equipped to deal with less serious illnesses, where general practitioners can look after their patients.

Although Israel has a high ratio of physicians to population, there is a shortage of general practitioners, and only in rural areas is general practice common. In the towns many people go directly to pediatricians, gynecologists, and other specialists, but there has been a reaction against this direct access to the specialist. More general practitioners have been trained, and the Israel Medical Association has recommended that no patient should be referred to a specialist except by the family physician or on instructions given by the family nurse. At Tel Aviv University there is a department of family medicine. In some newly developing areas, where the doctor shortage is greatest, there are medical centres at which all patients are initially interviewed by a nurse. The nurse may deal with many minor ailments, thus freeing the physician to treat the more seriously ill.

Nearly half the medical doctors in Australia are general practitionersa far higher proportion than in most other advanced countriesthough, as elsewhere, their numbers are declining. They tend to do far more for their patients than in Britain, many performing such operations as removal of the appendix, gallbladder, or uterus, operations that elsewhere would be carried out by a specialist surgeon. Group practices are common.

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Organization of health services

It is generally the goal of most countries to have their health services organized in such a way to ensure that individuals, families, and communities obtain the maximum benefit from current knowledge and technology available for the promotion, maintenance, and restoration of health. In order to play their part in this process, governments and other agencies are faced with numerous tasks, including the following: (1) They must obtain as much information as is possible on the size, extent, and urgency of their needs; without accurate information, planning can be misdirected. (2) These needs must then be revised against the resources likely to be available in terms of money, manpower, and materials; developing countries may well require external aid to supplement their own resources. (3) Based on their assessments, countries then need to determine realistic objectives and draw up plans. (4) Finally, a process of evaluation needs to be built into the program; the lack of reliable information and accurate assessment can lead to confusion, waste, and inefficiency.

Health services of any nature reflect a number of interrelated characteristics, among which the most obvious, but not necessarily the most important from a national point of view, is the curative function; that is to say, caring for those already ill. Others include special services that deal with particular groups (such as children or pregnant women) and with specific needs such as nutrition or immunization; preventive services, the protection of the health both of individuals and of communities; health education; and, as mentioned above, the collection and analysis of information.

In the curative domain there are various forms of medical practice. They may be thought of generally as forming a pyramidal structure, with three tiers representing increasing degrees of specialization and technical sophistication but catering to diminishing numbers of patients as they are filtered out of the system at a lower level. Only those patients who require special attention either for diagnosis or treatment should reach the second (advisory) or third (specialized treatment) tiers where the cost per item of service becomes increasingly higher. The first level represents primary health care, or first contact care, at which patients have their initial contact with the health-care system.

Primary health care is an integral part of a countrys health maintenance system, of which it forms the largest and most important part. As described in the declaration of Alma-Ata, primary health care should be based on practical, scientifically sound and socially acceptable methods and technology made universally accessible to individuals and families in the community through their full participation and at a cost that the community and country can afford to maintain at every stage of their development. Primary health care in the developed countries is usually the province of a medically qualified physician; in the developing countries first contact care is often provided by nonmedically qualified personnel.

The vast majority of patients can be fully dealt with at the primary level. Those who cannot are referred to the second tier (secondary health care, or the referral services) for the opinion of a consultant with specialized knowledge or for X-ray examinations and special tests. Secondary health care often requires the technology offered by a local or regional hospital. Increasingly, however, the radiological and laboratory services provided by hospitals are available directly to the family doctor, thus improving his service to patients and increasing its range. The third tier of health care, employing specialist services, is offered by institutions such as teaching hospitals and units devoted to the care of particular groupswomen, children, patients with mental disorders, and so on. The dramatic differences in the cost of treatment at the various levels is a matter of particular importance in developing countries, where the cost of treatment for patients at the primary health-care level is usually only a small fraction of that at the third level; medical costs at any level in such countries, however, are usually borne by the government.

Ideally, provision of health care at all levels will be available to all patients; such health care may be said to be universal. The well-off, both in relatively wealthy industrialized countries and in the poorer developing world, may be able to get medical attention from sources they prefer and can pay for in the private sector. The vast majority of people in most countries, however, are dependent in various ways upon health services provided by the state, to which they may contribute comparatively little or, in the case of poor countries, nothing at all.

The costs to national economics of providing health care are considerable and have been growing at a rapidly increasing rate, especially in countries such as the United States, Germany, and Sweden; the rise in Britain has been less rapid. This trend has been the cause of major concerns in both developed and developing countries. Some of this concern is based upon the lack of any consistent evidence to show that more spending on health care produces better health. There is a movement in developing countries to replace the type of organization of health-care services that evolved during European colonial times with some less expensive, and for them, more appropriate, health-care system.

In the industrialized world the growing cost of health services has caused both private and public health-care delivery systems to question current policies and to seek more economical methods of achieving their goals. Despite expenditures, health services are not always used effectively by those who need them, and results can vary widely from community to community. In Britain, for example, between 1951 and 1971 the death rate fell by 24 percent in the wealthier sections of the population but by only half that in the most underprivileged sections of society. The achievement of good health is reliant upon more than just the quality of health care. Health entails such factors as good education, safe working conditions, a favourable environment, amenities in the home, well-integrated social services, and reasonable standards of living.

The developing countries differ from one another culturally, socially, and economically, but what they have in common is a low average income per person, with large percentages of their populations living at or below the poverty level. Although most have a small elite class, living mainly in the cities, the largest part of their populations live in rural areas. Urban regions in developing and some developed countries in the mid- and late 20th century have developed pockets of slums, which are growing because of an influx of rural peoples. For lack of even the simplest measures, vast numbers of urban and rural poor die each year of preventable and curable diseases, often associated with poor hygiene and sanitation, impure water supplies, malnutrition, vitamin deficiencies, and chronic preventable infections. The effect of these and other deprivations is reflected by the finding that in the 1980s the life expectancy at birth for men and women was about one-third less in Africa than it was in Europe; similarly, infant mortality in Africa was about eight times greater than in Europe. The extension of primary health-care services is therefore a high priority in the developing countries.

The developing countries themselves, lacking the proper resources, have often been unable to generate or implement the plans necessary to provide required services at the village or urban poor level. It has, however, become clear that the system of health care that is appropriate for one country is often unsuitable for another. Research has established that effective health care is related to the special circumstances of the individual country, its people, culture, ideology, and economic and natural resources.

The rising costs of providing health care have influenced a trend, especially among the developing nations, to promote services that employ less highly trained primary health-care personnel who can be distributed more widely in order to reach the largest possible proportion of the community. The principal medical problems to be dealt with in the developing world include undernutrition, infection, gastrointestinal disorders, and respiratory complaints, which themselves may be the result of poverty, ignorance, and poor hygiene. For the most part, these are easy to identify and to treat. Furthermore, preventive measures are usually simple and cheap. Neither treatment nor prevention requires extensive professional training: in most cases they can be dealt with adequately by the primary health worker, a term that includes all nonprofessional health personnel.

Those concerned with providing health care in the developed countries face a different set of problems. The diseases so prevalent in the Third World have, for the most part, been eliminated or are readily treatable. Many of the adverse environmental conditions and public health hazards have been conquered. Social services of varying degrees of adequacy have been provided. Public funds can be called upon to support the cost of medical care, and there are a variety of private insurance plans available to the consumer. Nevertheless, the funds that a government can devote to health care are limited and the cost of modern medicine continues to increase, thus putting adequate medical services beyond the reach of many. Adding to the expense of modern medical practices is the increasing demand for greater funding of health education and preventive measures specifically directed toward the poor.

In many parts of the world, particularly in developing countries, people get their primary health care, or first-contact care, where available at all, from nonmedically qualified personnel; these cadres of medical auxiliaries are being trained in increasing numbers to meet overwhelming needs among rapidly growing populations. Even among the comparatively wealthy countries of the world, containing in all a much smaller percentage of the worlds population, escalation in the costs of health services and in the cost of training a physician has precipitated some movement toward reappraisal of the role of the medical doctor in the delivery of first-contact care.

In advanced industrial countries, however, it is usually a trained physician who is called upon to provide the first-contact care. The patient seeking first-contact care can go either to a general practitioner or turn directly to a specialist. Which is the wisest choice has become a subject of some controversy. The general practitioner, however, is becoming rather rare in some developed countries. In countries where he does still exist, he is being increasingly observed as an obsolescent figure, because medicine covers an immense, rapidly changing, and complex field of which no physician can possibly master more than a small fraction. The very concept of the general practitioner, it is thus argued, may be absurd.

The obvious alternative to general practice is the direct access of a patient to a specialist. If a patient has problems with vision, he goes to an eye specialist, and if he has a pain in his chest (which he fears is due to his heart), he goes to a heart specialist. One objection to this plan is that the patient often cannot know which organ is responsible for his symptoms, and the most careful physician, after doing many investigations, may remain uncertain as to the cause. Breathlessnessa common symptommay be due to heart disease, to lung disease, to anemia, or to emotional upset. Another common symptom is general malaisefeeling run-down or always tired; others are headache, chronic low backache, rheumatism, abdominal discomfort, poor appetite, and constipation. Some patients may also be overtly anxious or depressed. Among the most subtle medical skills is the ability to assess people with such symptoms and to distinguish between symptoms that are caused predominantly by emotional upset and those that are predominantly of bodily origin. A specialist may be capable of such a general assessment, but, often, with emphasis on his own subject, he fails at this point. The generalist with his broader training is often the better choice for a first diagnosis, with referral to a specialist as the next option.

It is often felt that there are also practical advantages for the patient in having his own doctor, who knows about his background, who has seen him through various illnesses, and who has often looked after his family as well. This personal physician, often a generalist, is in the best position to decide when the patient should be referred to a consultant.

The advantages of general practice and specialization are combined when the physician of first contact is a pediatrician. Although he sees only children and thus acquires a special knowledge of childhood maladies, he remains a generalist who looks at the whole patient. Another combination of general practice and specialization is represented by group practice, the members of which partially or fully specialize. One or more may be general practitioners, and one may be a surgeon, a second an obstetrician, a third a pediatrician, and a fourth an internist. In isolated communities group practice may be a satisfactory compromise, but in urban regions, where nearly everyone can be sent quickly to a hospital, the specialist surgeon working in a fully equipped hospital can usually provide better treatment than a general practitioner surgeon in a small clinic hospital.

Before 1948, general practitioners in Britain settled where they could make a living. Patients fell into two main groups: weekly wage earners, who were compulsorily insured, were on a doctors panel and were given free medical attention (for which the doctor was paid quarterly by the government); most of the remainder paid the doctor a fee for service at the time of the illness. In 1948 the National Health Service began operation. Under its provisions, everyone is entitled to free medical attention with a general practitioner with whom he is registered. Though general practitioners in the National Health Service are not debarred from also having private patients, these must be people who are not registered with them under the National Health Service. Any physician is free to work as a general practitioner entirely independent of the National Health Service, though there are few who do so. Almost the entire population is registered with a National Health Service general practitioner, and the vast majority automatically sees this physician, or one of his partners, when they require medical attention. A few people, mostly wealthy, while registered with a National Health Service general practitioner, regularly see another physician privately; and a few may occasionally seek a private consultation because they are dissatisfied with their National Health Service physician.

A general practitioner under the National Health Service remains an independent contractor, paid by a capitation fee; that is, according to the number of people registered with him. He may work entirely from his own office, and he provides and pays his own receptionist, secretary, and other ancillary staff. Most general practitioners have one or more partners and work more and more in premises built for the purpose. Some of these structures are erected by the physicians themselves, but many are provided by the local authority, the physicians paying rent for using them. Health centres, in which groups of general practitioners work have become common.

In Britain only a small minority of general practitioners can admit patients to a hospital and look after them personally. Most of this minority are in country districts, where, before the days of the National Health Service, there were cottage hospitals run by general practitioners; many of these hospitals continued to function in a similar manner. All general practitioners use such hospital facilities as X-ray departments and laboratories, and many general practitioners work in hospitals in emergency rooms (casualty departments) or as clinical assistants to consultants, or specialists.

General practitioners are spread more evenly over the country than formerly, when there were many in the richer areas and few in the industrial towns. The maximum allowed list of National Health Service patients per doctor is 3,500; the average is about 2,500. Patients have free choice of the physician with whom they register, with the proviso that they cannot be accepted by one who already has a full list and that a physician can refuse to accept them (though such refusals are rare). In remote rural places there may be only one physician within a reasonable distance.

Until the mid-20th century it was not unusual for the doctor in Britain to visit patients in their own homes. A general practitioner might make 15 or 20 such house calls in a day, as well as seeing patients in his office or surgery, often in the evenings. This enabled him to become a family doctor in fact as well as in name. In modern practice, however, a home visit is quite exceptional and is paid only to the severely disabled or seriously ill when other recourses are ruled out. All patients are normally required to go to the doctor.

It has also become unusual for a personal doctor to be available during weekends or holidays. His place may be taken by one of his partners in a group practice, a provision that is reasonably satisfactory. General practitioners, however, may now use one of several commercial deputizing services that employs young doctors to be on call. Although some of these young doctors may be well experienced, patients do not generally appreciate this kind of arrangement.

Whereas in Britain the doctor of first contact is regularly a general practitioner, in the United States the nature of first-contact care is less consistent. General practice in the United States has been in a state of decline in the second half of the 20th century, especially in metropolitan areas. The general practitioner, however, is being replaced to some degree by the growing field of family practice. In 1969 family practice was recognized as a medical specialty after the American Academy of General Practice (now the American Academy of Family Physicians) and the American Medical Association created the American Board of General (now Family) Practice. Since that time the field has become one of the larger medical specialties in the United States. The family physicians were the first group of medical specialists in the United States for whom recertification was required.

There is no national health service, as such, in the United States. Most physicians in the country have traditionally been in some form of private practice, whether seeing patients in their own offices, clinics, medical centres, or another type of facility and regardless of the patients income. Doctors are usually compensated by such state and federally supported agencies as Medicaid (for treating the poor) and Medicare (for treating the elderly); not all doctors, however, accept poor patients. There are also some state-supported clinics and hospitals where the poor and elderly may receive free or low-cost treatment, and some doctors devote a small percentage of their time to treatment of the indigent. Veterans may receive free treatment at Veterans Administration hospitals, and the federal government through its Indian Health Service provides medical services to American Indians and Alaskan natives, sometimes using trained auxiliaries for first-contact care.

In the rural United States first-contact care is likely to come from a generalist. The middle- and upper-income groups living in urban areas, however, have access to a larger number of primary medical care options. Children are often taken to pediatricians, who may oversee the childs health needs until adulthood. Adults frequently make their initial contact with an internist, whose field is mainly that of medical (as opposed to surgical) illnesses; the internist often becomes the family physician. Other adults choose to go directly to physicians with narrower specialties, including dermatologists, allergists, gynecologists, orthopedists, and ophthalmologists.

Patients in the United States may also choose to be treated by doctors of osteopathy. These doctors are fully qualified, but they make up only a small percentage of the countrys physicians. They may also branch off into specialties, but general practice is much more common in their group than among M.D.s.

It used to be more common in the United States for physicians providing primary care to work independently, providing their own equipment and paying their own ancillary staff. In smaller cities they mostly had full hospital privileges, but in larger cities these privileges were more likely to be restricted. Physicians, often sharing the same specialties, are increasingly entering into group associations, where the expenses of office space, staff, and equipment may be shared; such associations may work out of suites of offices, clinics, or medical centres. The increasing competition and risks of private practice have caused many physicians to join Health Maintenance Organizations (HMOs), which provide comprehensive medical care and hospital care on a prepaid basis. The cost savings to patients are considerable, but they must use only the HMO doctors and facilities. HMOs stress preventive medicine and out-patient treatment as opposed to hospitalization as a means of reducing costs, a policy that has caused an increased number of empty hospital beds in the United States.

While the number of doctors per 100,000 population in the United States has been steadily increasing, there has been a trend among physicians toward the use of trained medical personnel to handle some of the basic services normally performed by the doctor. So-called physician extender services are commonly divided into nurse practitioners and physicians assistants, both of whom provide similar ancillary services for the general practitioner or specialist. Such personnel do not replace the doctor. Almost all American physicians have systems for taking each others calls when they become unavailable. House calls in the United States, as in Britain, have become exceedingly rare.

In Russia general practitioners are prevalent in the thinly populated rural areas. Pediatricians deal with children up to about age 15. Internists look after the medical ills of adults, and occupational physicians deal with the workers, sharing care with internists.

Teams of physicians with experience in varying specialties work from polyclinics or outpatient units, where many types of diseases are treated. Small towns usually have one polyclinic to serve all purposes. Large cities commonly have separate polyclinics for children and adults, as well as clinics with specializations such as womens health care, mental illnesses, and sexually transmitted diseases. Polyclinics usually have X-ray apparatus and facilities for examination of tissue specimens, facilities associated with the departments of the district hospital. Beginning in the late 1970s was a trend toward the development of more large, multipurpose treatment centres, first-aid hospitals, and specialized medicine and health care centres.

Home visits have traditionally been common, and much of the physicians time is spent in performing routine checkups for preventive purposes. Some patients in sparsely populated rural areas may be seen first by feldshers (auxiliary health workers), nurses, or midwives who work under the supervision of a polyclinic or hospital physician. The feldsher was once a lower-grade physician in the army or peasant communities, but feldshers are now regarded as paramedical workers.

In Japan, with less rigid legal restriction of the sale of pharmaceuticals than in the West, there was formerly a strong tradition of self-medication and self-treatment. This was modified in 1961 by the institution of health insurance programs that covered a large proportion of the population; there was then a great increase in visits to the outpatient clinics of hospitals and to private clinics and individual physicians.

When Japan shifted from traditional Chinese medicine with the adoption of Western medical practices in the 1870s, Germany became the chief model. As a result of German influence and of their own traditions, Japanese physicians tended to prefer professorial status and scholarly research opportunities at the universities or positions in the national or prefectural hospitals to private practice. There were some pioneering physicians, however, who brought medical care to the ordinary people.

Physicians in Japan have tended to cluster in the urban areas. The Medical Service Law of 1963 was amended to empower the Ministry of Health and Welfare to control the planning and distribution of future public and nonprofit medical facilities, partly to redress the urban-rural imbalance. Meanwhile, mobile services were expanded.

The influx of patients into hospitals and private clinics after the passage of the national health insurance acts of 1961 had, as one effect, a severe reduction in the amount of time available for any one patient. Perhaps in reaction to this situation, there has been a modest resurgence in the popularity of traditional Chinese medicine, with its leisurely interview, its dependence on herbal and other natural medicines, and its other traditional diagnostic and therapeutic practices. The rapid aging of the Japanese population as a result of the sharply decreasing death rate and birth rate has created an urgent need for expanded health care services for the elderly. There has also been an increasing need for centres to treat health problems resulting from environmental causes.

On the continent of Europe there are great differences both within single countries and between countries in the kinds of first-contact medical care. General practice, while declining in Europe as elsewhere, is still rather common even in some large cities, as well as in remote country areas.

In The Netherlands, departments of general practice are administered by general practitioners in all the medical schoolsan exceptional state of affairsand general practice flourishes. In the larger cities of Denmark, general practice on an individual basis is usual and popular, because the physician works only during office hours. In addition, there is a duty doctor service for nights and weekends. In the cities of Sweden, primary care is given by specialists. In the remote regions of northern Sweden, district doctors act as general practitioners to patients spread over huge areas; the district doctors delegate much of their home visiting to nurses.

In France there are still general practitioners, but their number is declining. Many medical practitioners advertise themselves directly to the public as specialists in internal medicine, ophthalmologists, gynecologists, and other kinds of specialists. Even when patients have a general practitioner, they may still go directly to a specialist. Attempts to stem the decline in general practice are being made by the development of group practice and of small rural hospitals equipped to deal with less serious illnesses, where general practitioners can look after their patients.

Although Israel has a high ratio of physicians to population, there is a shortage of general practitioners, and only in rural areas is general practice common. In the towns many people go directly to pediatricians, gynecologists, and other specialists, but there has been a reaction against this direct access to the specialist. More general practitioners have been trained, and the Israel Medical Association has recommended that no patient should be referred to a specialist except by the family physician or on instructions given by the family nurse. At Tel Aviv University there is a department of family medicine. In some newly developing areas, where the doctor shortage is greatest, there are medical centres at which all patients are initially interviewed by a nurse. The nurse may deal with many minor ailments, thus freeing the physician to treat the more seriously ill.

Nearly half the medical doctors in Australia are general practitionersa far higher proportion than in most other advanced countriesthough, as elsewhere, their numbers are declining. They tend to do far more for their patients than in Britain, many performing such operations as removal of the appendix, gallbladder, or uterus, operations that elsewhere would be carried out by a specialist surgeon. Group practices are common.

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Benefits & Risks of Artificial Intelligence – Future of Life …

Many AI researchers roll their eyes when seeing this headline:Stephen Hawking warns that rise of robots may be disastrous for mankind. And as many havelost count of how many similar articles theyveseen.Typically, these articles are accompanied by an evil-looking robot carrying a weapon, and they suggest we should worry about robots rising up and killing us because theyve become conscious and/or evil.On a lighter note, such articles are actually rather impressive, because they succinctly summarize the scenario that AI researchers dontworry about. That scenario combines as many as three separate misconceptions: concern about consciousness, evil, androbots.

If you drive down the road, you have a subjective experience of colors, sounds, etc. But does a self-driving car have a subjective experience? Does it feel like anything at all to be a self-driving car?Although this mystery of consciousness is interesting in its own right, its irrelevant to AI risk. If you get struck by a driverless car, it makes no difference to you whether it subjectively feels conscious. In the same way, what will affect us humans is what superintelligent AIdoes, not how it subjectively feels.

The fear of machines turning evil is another red herring. The real worry isnt malevolence, but competence. A superintelligent AI is by definition very good at attaining its goals, whatever they may be, so we need to ensure that its goals are aligned with ours. Humans dont generally hate ants, but were more intelligent than they are so if we want to build a hydroelectric dam and theres an anthill there, too bad for the ants. The beneficial-AI movement wants to avoid placing humanity in the position of those ants.

The consciousness misconception is related to the myth that machines cant have goals.Machines can obviously have goals in the narrow sense of exhibiting goal-oriented behavior: the behavior of a heat-seeking missile is most economically explained as a goal to hit a target.If you feel threatened by a machine whose goals are misaligned with yours, then it is precisely its goals in this narrow sense that troubles you, not whether the machine is conscious and experiences a sense of purpose.If that heat-seeking missile were chasing you, you probably wouldnt exclaim: Im not worried, because machines cant have goals!

I sympathize with Rodney Brooks and other robotics pioneers who feel unfairly demonized by scaremongering tabloids,because some journalists seem obsessively fixated on robots and adorn many of their articles with evil-looking metal monsters with red shiny eyes. In fact, the main concern of the beneficial-AI movement isnt with robots but with intelligence itself: specifically, intelligence whose goals are misaligned with ours. To cause us trouble, such misaligned superhuman intelligence needs no robotic body, merely an internet connection this may enable outsmarting financial markets, out-inventing human researchers, out-manipulating human leaders, and developing weapons we cannot even understand. Even if building robots were physically impossible, a super-intelligent and super-wealthy AI could easily pay or manipulate many humans to unwittingly do its bidding.

The robot misconception is related to the myth that machines cant control humans. Intelligence enables control: humans control tigers not because we are stronger, but because we are smarter. This means that if we cede our position as smartest on our planet, its possible that we might also cede control.

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Benefits & Risks of Artificial Intelligence - Future of Life ...

A.I. Artificial Intelligence – Wikipedia

A.I. Artificial Intelligence, also known as A.I., is a 2001 American science fiction drama film directed by Steven Spielberg. The screenplay by Spielberg and screen story by Ian Watson were based on the 1969 short story "Supertoys Last All Summer Long" by Brian Aldiss. The film was produced by Kathleen Kennedy, Spielberg and Bonnie Curtis. It stars Haley Joel Osment, Jude Law, Frances O'Connor, Brendan Gleeson and William Hurt. Set in a futuristic post-climate change society, A.I. tells the story of David (Osment), a childlike android uniquely programmed with the ability to love.

Development of A.I. originally began with producer-director Stanley Kubrick, after he acquired the rights to Aldiss' story in the early 1970s. Kubrick hired a series of writers until the mid-1990s, including Brian Aldiss, Bob Shaw, Ian Watson, and Sara Maitland. The film languished in protracted development for years, partly because Kubrick felt computer-generated imagery was not advanced enough to create the David character, who he believed no child actor would convincingly portray. In 1995, Kubrick handed A.I. to Spielberg, but the film did not gain momentum until Kubrick's death in 1999. Spielberg remained close to Watson's film treatment for the screenplay.

The film divided critics, with the overall balance being positive, and grossed approximately $235 million. The film was nominated for two Academy Awards at the 74th Academy Awards, for Best Visual Effects and Best Original Score (by John Williams).

In a 2016 BBC poll of 177 critics around the world, Steven Spielberg's A.I. Artificial Intelligence was voted the eighty-third greatest film since 2000.[3] A.I. is dedicated to Stanley Kubrick.

In the late 22nd century, rising sea levels from global warming have wiped out coastal cities such as Amsterdam, Venice, and New York and drastically reduced the world's population. A new type of robots called Mecha, advanced humanoids capable of thought and emotion, have been created.

David, a Mecha that resembles a human child and is programmed to display love for his owners, is given to Henry Swinton and his wife Monica, whose son Martin, after contracting a rare disease, has been placed in suspended animation and not expected to recover. Monica feels uneasy with David, but eventually warms to him and activates his imprinting protocol, causing him to have an enduring childlike love for her. David is befriended by Teddy, a robotic teddy bear that belonged to Martin.

Martin is cured of his disease and brought home. As he recovers, he grows jealous of David. He tricks David into entering the parents's bedroom at night and cutting off a lock of Monica's hair. This upsets the parents, particularly Henry, who fears David intended to injure them. At a pool party, one of Martin's friends pokes David with a knife, activating David's self-protection programming. David grabs Martin and they fall into the pool. Martin is saved from drowning, but Henry persuades Monica to return David to his creators for destruction. Instead, she abandons David and Teddy in the forest. She warns David to avoid all humans, and tells him to find other unregistered Mecha who can protect him.

David is captured for an anti-Mecha "Flesh Fair", where obsolete, unlicensed Mecha are destroyed before cheering crowds. David is placed on a platform with Gigolo Joe, a male prostitute Mecha who is on the run after being framed for murder. Before the pair can be destroyed with acid, the crowd, thinking David is a real boy, begins booing and throwing things at the show's emcee. In the chaos, David and Joe escape. Since Joe survived thanks to David, he agrees to help him find Blue Fairy, whom David remembers from The Adventures of Pinocchio, and believes can turn him into a real boy, allowing Monica to love him and take him home.

Joe and David make their way to the decadent resort town of Rouge City, where "Dr. Know", a holographic answer engine, directs them to the top of Rockefeller Center in the flooded ruins of Manhattan. There, David meets a copy of himself and destroys it. He then meets Professor Hobby, his creator, who tells David he was built in the image of the professor's dead son David. The engineers are thrilled by his ability to have a will without being programmed. He reveals they have been monitoring him to see how he progresses and altered Dr. Know to guide him to Manhattan, back to the lab he was created in. David finds more copies of him, as well as female versions called Darlene, that have been made there.

Disheartened, David lets himself fall from a ledge of the building. He is rescued by Joe, flying an amphibicopter he has stolen from the police who were pursuing him. David tells Joe he saw the Blue Fairy underwater, and wants to go down to meet her. Joe is captured by the authorities, who snare him with an electromagnet. Before he is pulled up, he activates the amphibicopter's dive function for David, telling him to remember him for he declares "I am, I was." David and Teddy dive to see the Fairy, which turns out to be a statue at the now-sunken Coney Island. The two become trapped when the Wonder Wheel falls on their vehicle. David repeatedly asks the Fairy to turn him into a real boy. Eventually the ocean freezes and David's power source is depleted.

Two thousand years later, humans are extinct, and Manhattan is buried under glacial ice. The Mecha have evolved into an advanced silicon-based form called Specialists. They find David and Teddy, and discover they are original Mecha who knew living humans, making them special. The Specialists revive David and Teddy. David walks to the frozen Fairy statue, which collapses when he touches it. The Mecha use David's memories to reconstruct the Swinton home. David asks the Specialists if they can make him human, but they cannot. However, he insists they recreate Monica from DNA from the lock of her hair, which Teddy has kept. The Mecha warn David that the clone can live for only a day, and that the process cannot be repeated. David spends the next day with Monica and Teddy. Before she drifts off to sleep, Monica tells David she has always loved him. Teddy climbs onto the bed and watches the two lie peacefully together.

Kubrick began development on an adaptation of "Super-Toys Last All Summer Long" in the late 1970s, hiring the story's author, Brian Aldiss, to write a film treatment. In 1985, Kubrick asked Steven Spielberg to direct the film, with Kubrick producing.[6] Warner Bros. agreed to co-finance A.I. and cover distribution duties.[7] The film labored in development hell, and Aldiss was fired by Kubrick over creative differences in 1989.[8] Bob Shaw briefly served as writer, leaving after six weeks due to Kubrick's demanding work schedule, and Ian Watson was hired as the new writer in March 1990. Aldiss later remarked, "Not only did the bastard fire me, he hired my enemy [Watson] instead." Kubrick handed Watson The Adventures of Pinocchio for inspiration, calling A.I. "a picaresque robot version of Pinocchio".[7][9]

Three weeks later, Watson gave Kubrick his first story treatment, and concluded his work on A.I. in May 1991 with another treatment of 90 pages. Gigolo Joe was originally conceived as a G.I. Mecha, but Watson suggested changing him to a male prostitute. Kubrick joked, "I guess we lost the kiddie market."[7] Meanwhile, Kubrick dropped A.I. to work on a film adaptation of Wartime Lies, feeling computer animation was not advanced enough to create the David character. However, after the release of Spielberg's Jurassic Park, with its innovative computer-generated imagery, it was announced in November 1993 that production of A.I. would begin in 1994.[10] Dennis Muren and Ned Gorman, who worked on Jurassic Park, became visual effects supervisors,[8] but Kubrick was displeased with their previsualization, and with the expense of hiring Industrial Light & Magic.[11]

"Stanley [Kubrick] showed Steven [Spielberg] 650 drawings which he had, and the script and the story, everything. Stanley said, 'Look, why don't you direct it and I'll produce it.' Steven was almost in shock."

Producer Jan Harlan, on Spielberg's first meeting with Kubrick about A.I.[12]

In early 1994, the film was in pre-production with Christopher "Fangorn" Baker as concept artist, and Sara Maitland assisting on the story, which gave it "a feminist fairy-tale focus".[7] Maitland said that Kubrick never referred to the film as A.I., but as Pinocchio.[11] Chris Cunningham became the new visual effects supervisor. Some of his unproduced work for A.I. can be seen on the DVD, The Work of Director Chris Cunningham.[13] Aside from considering computer animation, Kubrick also had Joseph Mazzello do a screen test for the lead role.[11] Cunningham helped assemble a series of "little robot-type humans" for the David character. "We tried to construct a little boy with a movable rubber face to see whether we could make it look appealing," producer Jan Harlan reflected. "But it was a total failure, it looked awful." Hans Moravec was brought in as a technical consultant.[11]Meanwhile, Kubrick and Harlan thought A.I. would be closer to Steven Spielberg's sensibilities as director.[14][15] Kubrick handed the position to Spielberg in 1995, but Spielberg chose to direct other projects, and convinced Kubrick to remain as director.[12][16] The film was put on hold due to Kubrick's commitment to Eyes Wide Shut (1999).[17] After the filmmaker's death in March 1999, Harlan and Christiane Kubrick approached Spielberg to take over the director's position.[18][19] By November 1999, Spielberg was writing the screenplay based on Watson's 90-page story treatment. It was his first solo screenplay credit since Close Encounters of the Third Kind (1977).[20] Spielberg remained close to Watson's treatment, but removed various sex scenes with Gigolo Joe. Pre-production was briefly halted during February 2000, because Spielberg pondered directing other projects, which were Harry Potter and the Philosopher's Stone, Minority Report and Memoirs of a Geisha.[17][21] The following month Spielberg announced that A.I. would be his next project, with Minority Report as a follow-up.[22] When he decided to fast track A.I., Spielberg brought Chris Baker back as concept artist.[16]

The original start date was July 10, 2000,[15] but filming was delayed until August.[23] Aside from a couple of weeks shooting on location in Oxbow Regional Park in Oregon, A.I. was shot entirely using sound stages at Warner Bros. Studios and the Spruce Goose Dome in Long Beach, California.[24]The Swinton house was constructed on Stage 16, while Stage 20 was used for Rouge City and other sets.[25][26] Spielberg copied Kubrick's obsessively secretive approach to filmmaking by refusing to give the complete script to cast and crew, banning press from the set, and making actors sign confidentiality agreements. Social robotics expert Cynthia Breazeal served as technical consultant during production.[15][27] Haley Joel Osment and Jude Law applied prosthetic makeup daily in an attempt to look shinier and robotic.[4] Costume designer Bob Ringwood (Batman, Troy) studied pedestrians on the Las Vegas Strip for his influence on the Rouge City extras.[28] Spielberg found post-production on A.I. difficult because he was simultaneously preparing to shoot Minority Report.[29]

The film's soundtrack was released by Warner Sunset Records in 2001. The original score was composed and conducted by John Williams and featured singers Lara Fabian on two songs and Josh Groban on one. The film's score also had a limited release as an official "For your consideration Academy Promo", as well as a complete score issue by La-La Land Records in 2015.[30] The band Ministry appears in the film playing the song "What About Us?" (but the song does not appear on the official soundtrack album).

Warner Bros. used an alternate reality game titled The Beast to promote the film. Over forty websites were created by Atomic Pictures in New York City (kept online at Cloudmakers.org) including the website for Cybertronics Corp. There were to be a series of video games for the Xbox video game console that followed the storyline of The Beast, but they went undeveloped. To avoid audiences mistaking A.I. for a family film, no action figures were created, although Hasbro released a talking Teddy following the film's release in June 2001.[15]

A.I. had its premiere at the Venice Film Festival in 2001.[31]

A.I. Artificial Intelligence was released on VHS and DVD by Warner Home Video on March 5, 2002 in both a standard full-screen release with no bonus features, and as a 2-Disc Special Edition featuring the film in its original 1.85:1 anamorphic widescreen format as well as an eight-part documentary detailing the film's development, production, music and visual effects. The bonus features also included interviews with Haley Joel Osment, Jude Law, Frances O'Connor, Steven Spielberg and John Williams, two teaser trailers for the film's original theatrical release and an extensive photo gallery featuring production sills and Stanley Kubrick's original storyboards.[32]

The film was released on Blu-ray Disc on April 5, 2011 by Paramount Home Media Distribution for the U.S. and by Warner Home Video for international markets. This release featured the film a newly restored high-definition print and incorporated all the bonus features previously included on the 2-Disc Special Edition DVD.[33]

The film opened in 3,242 theaters in the United States on June 29, 2001, earning $29,352,630 during its opening weekend. A.I went on to gross $78.62 million in US totals as well as $157.31 million in foreign countries, coming to a worldwide total of $235.93 million.[34]

Based on 192 reviews collected by Rotten Tomatoes, 73% of critics gave the film positive notices with a score of 6.6/10. The website's critical consensus reads, "A curious, not always seamless, amalgamation of Kubrick's chilly bleakness and Spielberg's warm-hearted optimism. A.I. is, in a word, fascinating."[35] By comparison, Metacritic collected an average score of 65, based on 32 reviews, which is considered favorable.[36]

Producer Jan Harlan stated that Kubrick "would have applauded" the final film, while Kubrick's widow Christiane also enjoyed A.I.[37] Brian Aldiss admired the film as well: "I thought what an inventive, intriguing, ingenious, involving film this was. There are flaws in it and I suppose I might have a personal quibble but it's so long since I wrote it." Of the film's ending, he wondered how it might have been had Kubrick directed the film: "That is one of the 'ifs' of film historyat least the ending indicates Spielberg adding some sugar to Kubrick's wine. The actual ending is overly sympathetic and moreover rather overtly engineered by a plot device that does not really bear credence. But it's a brilliant piece of film and of course it's a phenomenon because it contains the energies and talents of two brilliant filmmakers."[38] Richard Corliss heavily praised Spielberg's direction, as well as the cast and visual effects.[39] Roger Ebert gave the film three stars, saying that it was "wonderful and maddening."[40] Leonard Maltin, on the other hand, gives the film two stars out of four in his Movie Guide, writing: "[The] intriguing story draws us in, thanks in part to Osment's exceptional performance, but takes several wrong turns; ultimately, it just doesn't work. Spielberg rewrote the adaptation Stanley Kubrick commissioned of the Brian Aldiss short story 'Super Toys Last All Summer Long'; [the] result is a curious and uncomfortable hybrid of Kubrick and Spielberg sensibilities." However, he calls John Williams' music score "striking". Jonathan Rosenbaum compared A.I. to Solaris (1972), and praised both "Kubrick for proposing that Spielberg direct the project and Spielberg for doing his utmost to respect Kubrick's intentions while making it a profoundly personal work."[41] Film critic Armond White, of the New York Press, praised the film noting that "each part of David's journey through carnal and sexual universes into the final eschatological devastation becomes as profoundly philosophical and contemplative as anything by cinema's most thoughtful, speculative artists Borzage, Ozu, Demy, Tarkovsky."[42] Filmmaker Billy Wilder hailed A.I. as "the most underrated film of the past few years."[43] When British filmmaker Ken Russell saw the film, he wept during the ending.[44]

Mick LaSalle gave a largely negative review. "A.I. exhibits all its creators' bad traits and none of the good. So we end up with the structureless, meandering, slow-motion endlessness of Kubrick combined with the fuzzy, cuddly mindlessness of Spielberg." Dubbing it Spielberg's "first boring movie", LaSalle also believed the robots at the end of the film were aliens, and compared Gigolo Joe to the "useless" Jar Jar Binks, yet praised Robin Williams for his portrayal of a futuristic Albert Einstein.[45][not in citation given] Peter Travers gave a mixed review, concluding "Spielberg cannot live up to Kubrick's darker side of the future." But he still put the film on his top ten list that year for best movies.[46] David Denby in The New Yorker criticized A.I. for not adhering closely to his concept of the Pinocchio character. Spielberg responded to some of the criticisms of the film, stating that many of the "so called sentimental" elements of A.I., including the ending, were in fact Kubrick's and the darker elements were his own.[47] However, Sara Maitland, who worked on the project with Kubrick in the 1990s, claimed that one of the reasons Kubrick never started production on A.I. was because he had a hard time making the ending work.[48] James Berardinelli found the film "consistently involving, with moments of near-brilliance, but far from a masterpiece. In fact, as the long-awaited 'collaboration' of Kubrick and Spielberg, it ranks as something of a disappointment." Of the film's highly debated finale, he claimed, "There is no doubt that the concluding 30 minutes are all Spielberg; the outstanding question is where Kubrick's vision left off and Spielberg's began."[49]

Screenwriter Ian Watson has speculated, "Worldwide, A.I. was very successful (and the 4th highest earner of the year) but it didn't do quite so well in America, because the film, so I'm told, was too poetical and intellectual in general for American tastes. Plus, quite a few critics in America misunderstood the film, thinking for instance that the Giacometti-style beings in the final 20 minutes were aliens (whereas they were robots of the future who had evolved themselves from the robots in the earlier part of the film) and also thinking that the final 20 minutes were a sentimental addition by Spielberg, whereas those scenes were exactly what I wrote for Stanley and exactly what he wanted, filmed faithfully by Spielberg."[50]

In 2002, Spielberg told film critic Joe Leydon that "People pretend to think they know Stanley Kubrick, and think they know me, when most of them don't know either of us". "And what's really funny about that is, all the parts of A.I. that people assume were Stanley's were mine. And all the parts of A.I. that people accuse me of sweetening and softening and sentimentalizing were all Stanley's. The teddy bear was Stanley's. The whole last 20 minutes of the movie was completely Stanley's. The whole first 35, 40 minutes of the film all the stuff in the house was word for word, from Stanley's screenplay. This was Stanley's vision." "Eighty percent of the critics got it all mixed up. But I could see why. Because, obviously, I've done a lot of movies where people have cried and have been sentimental. And I've been accused of sentimentalizing hard-core material. But in fact it was Stanley who did the sweetest parts of A.I., not me. I'm the guy who did the dark center of the movie, with the Flesh Fair and everything else. That's why he wanted me to make the movie in the first place. He said, 'This is much closer to your sensibilities than my own.'"[51]

Upon rewatching the film many years after its release, BBC film critic Mark Kermode apologized to Spielberg in an interview in January 2013 for "getting it wrong" on the film when he first viewed it in 2001. He now believes the film to be Spielberg's "enduring masterpiece".[52]

Visual effects supervisors Dennis Muren, Stan Winston, Michael Lantieri and Scott Farrar were nominated for the Academy Award for Best Visual Effects, while John Williams was nominated for Best Original Music Score.[53] Steven Spielberg, Jude Law and Williams received nominations at the 59th Golden Globe Awards.[54] A.I. was successful at the Saturn Awards, winning five awards, including Best Science Fiction Film along with Best Writing for Spielberg and Best Performance by a Younger Actor for Osment.[55]

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A.I. Artificial Intelligence - Wikipedia

Artificial Intelligence: The Pros, Cons, and What to Really Fear

For the last several years, Russia has been steadily improving its ground combat robots. Just last year,Kalashnikov, the maker of the famous AK-47 rifle,announced it would builda range of products based on neural networks, including a fully automated combat module that promises to identify and shoot at targets.

According to Bendett,Russia delivered a white paperto the UN saying that from Moscow's perspective,it would be inadmissible to leave UASwithout anyhuman oversight. In other words, Russia always wants a human in the loop and to be the one to push the final button to fire that weapon.

Worth noting: "A lot of these are still kind of far-out applications," Bendett said.

The same can be said for China's more military-focused applications of AI, largely in surveillance and UAV operations for the PLA,said Elsa Kania, Technology Fellow at the Center for a New American Security. Speaking beside Bendett at the Genius Machines event in March, Kania said China's military applications appear to beat a a fairly nascent stage in its development.

That is to say: There'snothing to fear about lethal AI applications yet unless you're an alleged terrorist in the Middle East. For the rest of us, we have our Siris, Alexas, Cortanas and more, helping us shop, search, listen to music,and tag friends in images on social media.

Until the robot uprising comes, let us hope there will always be clips ofthe swearing Atlas Robot from Boston Dynamics available online whenever we need a laugh. It may be better to laugh before these robots start helping each other through doorwaysentirely independent of humans. (Too late.)

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Artificial Intelligence: The Pros, Cons, and What to Really Fear