Artificial Intelligence has come a long way since it was in its blooming stages in the 1940s. It was a time when the direct interaction between AI and humans seemed impossible and people were even scared by the thought. All sorts of theories started emerging that made artificial intelligence look deadly for humans. The idea of robots or droids were thought of as something that could hurt the human population and even drive them to extinction. In spite of all theories, researchers were able to predict one thing for sure. Artificial intelligence will be able to transform lives and the way humans interact with one another. It will reshape the societies and industries that we know today.

Welcome to 2019, an era where artificial intelligence is vividly present all around us. In other words, we are living in the age of AI. Take a look around you. Be it the smart assistant on our mobile phones, websites, e-commerce platforms, search engine results, home automation appliances, classrooms, and more. Every single element is trying to adopt AI and cause an impact for the good. This is in turn radically transformssocieties and pushespeople to develop emotional bonding with their gadgets and AI devices. Today, when we want to find directions to a place, we do not stop by strangers and ask them. Instead, we turn on Google maps and let technology guide us.

One of the biggest breakthroughs in artificial intelligence has been its implementation in the healthcare sector. One of the most fundamental industries in the world, the healthcare sector is far behind in todays world. Even though technological marvels are constantly fascinating in the world, there is a significant amount of work that needs to be done in the healthcare sector. From diagnosis to medicine and providing healthcare facilities in rural areas, artificial intelligence has a lot of scope for health care support.

However, there has been some significant progress in the healthcare industry. All thanks to artificial intelligence that was powered by the wave of digitization. As more and more organizations are turning digital, its providing an abundance of data for machines to work upon them. Now we have robots that are successfully performing surgery on patients, software programs that are better diagnosing diseases far better than traditional pathological practices, and wearable devices that can monitor our health and send updates about alarming situations in real-time.

Still, theres an emerging need for transformation in the field of medicine. We still have drugs that address the concern of a mass population, only to leave a few with side effects. Similarly, diseases like cancer do not have any permanent remedy or targeted course of medication that treats the patient well without leaving them with any side effects. Similarly, people over the age of 50 are one of the fastest-growing demographic groups around the world. Its creating a lot of challenges for the global economy and the healthcare sector. These people need to be provided with efficient care and medical support that is targeted towards the longevity of their lives.

The Longevity Industry that provides healthcare support to the population above 50 is turning into a multi-trillion dollar industry, with close to 260 companies in the UK alone. Any progress in the longevity distribution at scale will have a huge impact and multiplicative effects on economies and societies around the world. After all, it would be a huge loss if the experienced population who have been responsible for more than a few innovations in the world are facing sudden deterioration in health in a way that reduces their quality of life. Not only will it be a huge loss to the economies but also result in increased dependency on the healthcare system. Having said this, artificial intelligence has a lot of potentials to manifest in this field and come up with solutions that target the emerging needs of the population accurately.

Research indicates that increasing the lifespan of humans even by one year will decrease the suffering of tens of millions of people and improve the quality of life for billions of others. One such effort in this direction is personalized medicine that targets the individual needs of humans with precision. So, lets say that if a person has asthma, precision medicine will only focus and target the cells that are responsible for asthma and help in regenerating them. This would leave other portions or tissues of the human body untouched and treat only what was needed. Therefore, in place of treating generalized symptoms, AI can help shift medicine towards prevention, personalization and ultimately precision.

With the advent of digitization in the healthcare sector, more and more patent records are going digital. This practice is helping researchers and medical experts understand the history of a patient in detail with the past treatments and health support theyve received. The vast amount of data collected from thousands of such medical records can be studied and used by AI to understand how a particular treatment can impact a particular gene inside the human. Moreover, digitization is also enabling researchers from all walks of life to work together, thus, laying an excellent foundation for biotechnology and computer experts to work together towards personalized medicine.

For example, CRISPR is a gene-editing technology that is being used to target the DNA sequences precisely. With this, medical experts can deliberately activate or inhibit certain genes in human beings. This demonstrates that there is a strong ability to target an individuals distinctive molecular and genetic profile, thus opening up new opportunities for personalized medicine.The National Institute of Health describes precision medicine as an emerging approach for the treatment of diseases and their prevention, which takes a persons gene variability, environment and lifestyle into account. It requires the assistance of deep learning algorithms that can learn from the data at an unprecedented rate and combine the knowledge of medical experts to reach a decision.

However, precision medicine will not be the end of human touch. It will still require vast expertise of medical experts to analyze the results obtained from machines and understand its real-world implications for the patient. With wearable devices, electronic health records and information about the geographic and demographic history of the patient, deep learning algorithms in AI have a lot of potential to device personalized medicine for people that target precision issues with high accuracy.

This article was originally published on Towards Data Science byJames Warner, a business intelligence analyst with knowledge on Hadoop/Big data analysis at NexSoftSys.com

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Thanks to AI, medical treatments are becoming more personalized - The Next Web

Meaning of life: No one can tell its real definition. For some, it is all about happiness, building family, and leading life as it is. For some, it is about accumulating wealth, whereas, for many, life is all about love money, etc.

Many think about the meaning and purpose in life from a philosophical perspective, but the meaning in life is associated with better health, wellness, and perhaps longevity.

A new study by the University of California San Diego School of Medicine found the meaning in life is essential for health and well-being, though the relationships differ in adults younger and older than age 60.

The study found that the meaning of life is associated with better physical and mental well-being, while the search for meaning in life may be associated with worse mental well-being and cognitive functioning.

Dilip V. Jeste, MD, senior associate dean for the Center of Healthy Aging and Distinguished Professor of Psychiatry and Neurosciences at UC San Diego School of Medicine said, When you find more meaning in life, you become more contented, whereas if you dont have purpose in life and are searching for it unsuccessfully, you will feel much more stressed out.

The Presence of meaning in life displayed an inverted U-shaped relationship, while the quest for meaning in life demonstrated a U-shaped relation with age. The analysts found that age 60 is when the presence of purpose in life peaks, and the search for the importance of life was at its absolute bottom.

Jeste said, When you are young, like in your twenties, you are unsure about your career, a life partner, and who you are as a person. You are searching for meaning in life. As you start to get into your thirties, forties, and fifties, you have more established relationships, maybe you are married and have a family, and youve settled in a career. The search decreases, and the meaning in life increases.

After age 60, things begin to change. People retire from their job and start to lose their identity. They start to develop health issues, and some of their friends and family begin to pass away. They start searching for the meaning in life again because the meaning they once had has changed.

A total of 1,042 adults, ages 21 to 100-plus, were involved in the study, where they were assessed with interviews, including meaning in life questionnaire. Participants were then asked to rate items such as I am seeking a purpose or mission for my life and I have discovered a satisfying life purpose.

Awais Aftab, MD, first author of the paper and a former fellow in the Department of Psychiatry at UC San Diego said, The medical field is beginning to recognize that meaning in life is a clinically relevant and potentially modifiable factor, which can be targeted to enhance the well-being and functioning of patients. We anticipate that our findings will serve as building blocks for the development of new interventions for patients searching for purpose.

Further study is required to look at the other areas, such as wisdom, loneliness and compassion, and how these impact meaning in life. Although, examing the biomarkers such as stress and aging, etc. all are associated with searching and finding the purpose in life.

The study is published in the Journal of Clinical Psychiatry.

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What is the real meaning of life? A study found the answer - Tech Explorist

Modern medicine and healthcare have made living long lives a very real possibility. While most of the methods used depend on medical or surgical procedures, experts suggest that leading a healthy lifestyle plays a key role in helping you live a long life.

And this is where the Blue Zones diet comes in. Recent research has shown that adopting the lifestyle habits of those who live in the Blue Zones will help you extend your life beyond the age of 100 years. How exactly does this lifestyle system work? Lets find out.

Representational image. Image source: Getty Images.

In 2005, Dan Buettner did a cover story, Secrets of Long Life, for the National Geographic Magazines November edition, where he described how the centenarians (those who have lived beyond the age of 100 years) of the world lived, where they were located, what they ate, and how they were able to elongate their lives.

The story inevitably captured the imagination of people, and in 2006 Buettner and a team of demographers, scientists and anthropologists conducted deeper research into the specific regions (or zones) where the highest percentage of centenarians live. These zones are:

Despite the huge geographical and cultural differences between each of these zones, the researchers noticed nine common denominators and lifestyle characteristics that the residents of these zones shared. These characteristics were then named the Power 9 and are listed as follows:

1. Move naturally

You might think strenuous or mindful workouts in the gym multiple times a week or training for or running marathons might contribute to a long lifespan, but the people of the Blue Zones do none of these. They just live in environments where movement or activity is constant. Unlike the sedentary, desk-bound professional lives the rest of the world lives, most centenarians engage in jobs like gardening, housework or working outdoors in other ways. They do not use mechanical or electronic conveniences that cut out the natural movements of the body.

2. Purpose

Why do you wake up in the morning? Do you have a sense of purpose? You might think these are spiritual questions that have nothing to do with living a long life, but the residents of the Blue Zones disagree. Knowing your sense of purpose is worth up to 7 years of extra life expectancy, Buettner wrote in his report published in the American Journal of Lifestyle Medicine in 2016. Take a page out of the book of those who have lived beyond 100, find your purpose in life and work towards it.

3. Downshift

You might not realise it while you are busy worrying incessantly about that target or deadline at work, the disputes in your personal life, or the larger goals in life that you are unable to achieve - but stress does not add to your life, and it definitely does take away valuable years. Its not that people in the Blue Zones dont experience stress. They do. But they take a downshift or some time to shed off that stress effectively. Okinawans take a few moments each day to remember their ancestors; Adventists pray; Ikarians take a nap; and Sardinians do happy hour, Buettner wrote.

4. 80% Rule

Gluttony is actually very harmful to your health - and not because it's a "sin". People in the Blue Zones believe in the 80% rule, and it has clearly served them well in living long lives. Hara hachi bu - the Okinawan 2500-year old Confucian mantra said before meals - reminds them to stop eating when their stomachs are 80% full, Buettner wrote. The 20% gap between not being hungry and feeling full could be the difference between losing weight or gaining it. So, stop before you overstuff yourself, cut back till about 80% and you wont just avoid weight gain - you might even end up living longer.

5. Plant slant

What do centenarians from all the Blue Zones definitely eat, despite the huge difference in the local foods available to them? Beans, including fava, black, soy, and lentils, Buettner wrote. Eating plant-based meals most of the time does not mean that you must stop eating meat though. In fact, the people from the Blue Zones arent necessarily vegetarian. They eat meat, including pork, but only 5 times per month on an average. The focus should be on more plant intake rather than meat intake.

6. Wine @ 5

Heres some good news for fans of red wine: drinking one or two glasses of red wine, specifically Sardinian Connonau, in the company of good friends and good food can help you live longer based on the evidence gathered from the Blue Zones population. People in all Blue Zones (except Adventists) drink alcohol moderately and regularly. Moderate drinkers outlive non-drinkers, Buettner wrote. As he said though, moderation is key. You cannot drink a weeks worth of alcohol in one go and expect it to do anything but harm.

7. Belong

Having faith can also add years to your life, Buettners research proves. All but 5 of the 263 centenarians interviewed belonged to some faith-based community, he wrote, while adding that attending faith-based services 4 times per month will add 4 to 14 years of life expectancy. It doesnt matter what your specific faith or religion or belief-system is as long as you do have one and a community of fellow-believers who meet up to share the faith at least four times a month.

8. Loved ones first

Buettner wrote that putting family first also plays a role. He goes on to explain that keeping ageing parents and grandparents close (or living with them), having a life partner, and investing more time and love in your children actually helps elongate life. This has a lot to do with mental health and care because if you invest in your family you are more likely to be looked after and feel happy. It also reduces disease and mortality rates and can increase life expectancy.

9. Right tribe

Finding your tribe, or the right set of people who can provide lifelong support is apparently a big factor of longevity. Buettner wrote about how people in the Blue Zones are born into or maintain social circles that supported healthy behaviours. The presence of a social circle also seemed to keep vices like smoking away and promote happiness. Create and sustain a reaffirming group of lifelong friends, and you might just be able to fight depression, obesity and beat ageing.

As you can see, the Blue Zones Diet is more about changing your lifestyle rather than just focusing on food or exercise. It promotes a healthy and happy way of living which finally pushes back the time of death by decades when done right. If you can accomplish all the changes, maybe you too will live to be a centenarian.

For more information, please read our article onBlue Zone Diet.

Health articles in Firstpost are written by myUpchar.com, Indias first and biggest resource for verified medical information. At myUpchar, researchers and journalists work with doctors to bring you information on all things health.

Updated Date: Dec 10, 2019 18:14:33 IST

Tags : Blue Zones, Blue Zones Diet, Centenarians, Dan Buettner, Diet For Longer Life, Diet Tips, Healthy Diet, Longevity, NewsTracker

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Blue Zones Diet: Will following this diet help you live for 100 years? - Firstpost

Available on PerkinElmers automated GSP instrument, kit supports early diagnosis by measuring CK-MM concentration instead of CK enzyme activity

PerkinElmer, Inc., (NYSE: PKI), a global leader committed to innovating for a healthier world, today announced that its GSP Neonatal Creatine Kinase MM (CK-MM) kit has received U.S. Food & Drug Administration (FDA) approval. This solution is the first commercially available assay for screening newborns affected by Duchenne muscular dystrophy (DMD).

DMD is an X-linked recessive disease and the most prevalent type of muscular dystrophy, affecting approximately 1 in 5,000 live male births. The disorder is caused by mutations in the dystrophin gene, which supports the mechanical strength of muscle fibers. Without dystrophin, a patients muscles progressively weaken and deteriorate, ultimately resulting in premature death from poor respiratory function and cardiac failure.

Although there is no known cure, recent studies demonstrate the importance of early intervention and treatment. In particular, steroid treatments like corticosteroids have been proven to support muscle repair and reduce detrimental side effects in infants, underscoring the need for DMD testing at the earliest point in life.1 PerkinElmers kit is specifically designed for screening newborn babies by measuring CK-MMthe predominant isoform in skeletal muscle cells and most specific to skeletal muscle damagein dried blood spot samples.2 CK-MM levels are typically elevated in DMD patients, as the degeneration of skeletal muscle cells causes CK to release into the bloodstream.

"It is a cost-effective way to screen for DMD with a two-tier testing approach; the first tier CK-MM assay allows identification of infants with excess muscle damage at birth, and the second tier DMD gene analysis would link the muscle damage to the genetic defect," said Mei Baker, MD, FACMG, professor in the Department of Pediatrics and Co-Director in the Newborn Screening Laboratory at the University of Wisconsin School of Medicine and Public Health.

"Screening newborns not only prevents DMD patients and their families from an unnecessary diagnostic odyssey, but also ensures timely treatment for a disease that could otherwise go undetected for years," said Linh Hoang, M.D., Ph.D., Vice President, Reproductive Health, PerkinElmer. "By measuring the muscle-specific isoform, rather than total CK activity, PerkinElmers assay enables clinicians to identify babies with this condition faster and, most importantly, give them a better chance at improved health outcomes."

For more information on PerkinElmers CK-MM assay and other newborn screening solutions, please visit: newbornscreening.perkinelmer.com.

About PerkinElmer

PerkinElmer enables scientists, researchers and clinicians to address their most critical challenges across science and healthcare. With a mission focused on innovating for a healthier world, we deliver unique solutions to serve the diagnostics, life sciences, food and applied markets. We strategically partner with customers to enable earlier and more accurate insights supported by deep market knowledge and technical expertise. Our dedicated team of about 13,000 employees worldwide is passionate about helping customers work to create healthier families, improve the quality of life, and sustain the wellbeing and longevity of people globally. The Company reported revenue of approximately $2.8 billion in 2018, serves customers in more than 150 countries, and is a component of the S&P 500 index. Additional information is available through 1-877-PKI-NYSE, or at http://www.perkinelmer.com.

1 Connolly AM, Zaidman CM, Golumbek PT, Cradock MM, Flanigan KM, Kuntz NL, Finkel RS, McDonald CM, Iannaccone ST, Anand P, Siener CA, Florence JM, Lowes LP, Alfano LN, Johnson LB, Nicorici A, Nelson LL, Mendell JR. (2019). Twice weekly Glucocorticosteroids in Infants and Young boys with Duchenne Muscular Dystrophy: Steroids in young boys with DMD. Muscle & Nerve. 10.1002/mus.26441.2 Moat SJ, Korpimki T, Furu P, Hakala H, Polari H, Meri L, Mkinen P, Weeks I. Characterization of a blood spot creatine kinase skeletal muscle isoform immunoassay for high-throughput newborn screening of Duchenne muscular dystrophy. Clin Chem 2017;63:908-14.

View source version on businesswire.com: https://www.businesswire.com/news/home/20191213005240/en/

Contacts

Brian Willinskybrian.willinsky@perkinelmer.com +1-781-663-5728

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PerkinElmer Launches First FDA-Approved Assay Kit to Screen for Duchenne Muscular Dystrophy in Newborns - Yahoo Finance

Over the last three decades, meaning in life has emerged as an important question in medical research, especially in the context of an aging population.

A recent study by researchers at University of California San Diego School of Medicine found that the presence of and search for meaning in life are important for health and well-being, though the relationships differ in adults younger and older than age 60.

Many think about the meaning and purpose in life from a philosophical perspective, but meaning in life is associated with better health, wellness and perhaps longevity, said senior author Dilip V. Jeste, M.D., senior associate dean for the Center of Healthy Aging and Distinguished Professor of Psychiatry and Neurosciences at UC San Diego School of Medicine. Those with meaning in life are happier and healthier than those without it.

The study, published online in the December 10, 2019 edition of theJournal of Clinical Psychiatry, found the presence of meaning in life is associated with better physical and mental well-being, while the search for meaning in life may be associated with worse mental well-being and cognitive functioning. When you find more meaning in life, you become more contented, whereas if you dont have purpose in life and are searching for it unsuccessfully, you will feel much more stressed out, said Jeste.

The results also showed that the presence of meaning in life exhibited an inverted U-shaped relationship, while the search for meaning in life showed a U-shaped relationship with age. The researchers found that age 60 is when the presence of meaning in life peaks and the search for meaning of life was at its lowest point.

When you are young, like in your twenties, you are unsure about your career, a life partner and who you are as a person. You are searching for meaning in life, said Jeste. As you start to get into your thirties, forties and fifties, you have more established relationships, maybe you are married and have a family and youre settled in a career. The search decreases and the meaning in life increases.

After age 60, things begin to change. People retire from their job and start to lose their identity. They start to develop health issues and some of their friends and family begin to pass away. They start searching for the meaning in life again because the meaning they once had has changed.

The three-year, cross-sectional study examined data from 1,042 adults, ages 21 to 100-plus, who were part of the Successful Aging Evaluation (SAGE) a multi-cohort study of senior residents living in San Diego County. The presence and search for meaning in life were assessed with interviews, including a meaning in life questionnaire where participants were asked to rate items, such as, I am seeking a purpose or mission for my life and I have discovered a satisfying life purpose.

The medical field is beginning to recognize that meaning in life is a clinically relevant and potentially modifiable factor, which can be targeted to enhance the well-being and functioning of patients, said Awais Aftab, M.D., first author of the paper and a former fellow in the Department of Psychiatry at UC San Diego. We anticipate that our findings will serve as building blocks for the development of new interventions for patients searching for purpose.

Jeste said next research steps include looking at other areas, such as wisdom, loneliness and compassion, and how these impact meaning in life. We also want to examine if some biomarkers of stress and aging are associated with searching and finding the meaning in life. Its an exciting time in this field as we are seeking to discover evidence-based answers to some of lifes most profound questions.

Co-authors include: Ellen Lee, Federica Klaus, Rebecca Daly, Tsung-Chin Wu, Xin Tu and Steven Huege, all at UC San Diego.

Funding for this research came, in part, from the National Institutes of Health and National Institute of Mental Health (grants NIMH T32, MH019934, R01MH094151-01, NIMH K23MH119375-01, NIH UL1TR001442), the Brain and Behavior Research Foundation, the Swiss National Science Foundation, the Veterans Affairs San Diego Healthcare System and the Stein Institute for Research and Aging.

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Have you found meaning in life? Your answer influences your health and well-being - University of California

Recording artist, songwriter, essayist, investor, and so much more:D.A. Wallach is a true polymath. In this episode, among the highlights, D.A. provides compelling and colorful insight into how the music industry works today vs the past, liquid biopsies, how to approach healthspan, and how we can reach a singularity in medicine.

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D.A. Wallach is a recording artist, songwriter, investor, and essayist who Kanye West and Pharrell Williams discovered while he was an undergraduate at Harvard College. He has been featured in GQ, Rolling Stone, Vogue, and numerous other publications, and has toured with N*E*R*D, Lady Gaga, and Weezer. D.A. has also performed on TV Shows including Jimmy Kimmel Live and Late Night with Jimmy Fallon.

As one half of Chester French, D.A. has released three full-length albums, and has written and performed on records with Janelle Monae, Rick Ross, Diddy, and many others. His solo debut for Capitol Records, Time Machine, is available at: http://www.TimeMachineAlbum.com

Beyond music, D.A. invests in and advises several start-up technology companies, including SpaceX, Doctor On Demand, Ripple, Emulate and Spotify, where he was the official Artist in Residence. Forbes selected D.A. as one of its 30 Under 30 and Fast Company named him one of the 100 Most Creative People in Business. In 2015, he launched Inevitable Ventures, an investment partnership with multibillionaire Ron Burkle that supports radical entrepreneurs in areas including health care, the life sciences, and financial technologies.

In 2016, D.A. made his feature film debut in La La Land, which won a record number of Golden Globe Awards and received 14 Academy Award nominations, making it one of the 3 most nominated films in history. He frequently publishes essays on media, technology, and philosophy at dawallach.com and Medium. [dawallach.com]

DA on Facebook: D.A. Wallach

DA on Instagram: @dawallach

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#06 - D.A. Wallach: music, medicine, longevity, and ...

Dramatic breakthroughs in medicine, public health, and social and economic development have resulted in unprecedented extensions of the human lifespan across the world over the past century. This triumph for humanity provides new opportunities as well as new challenges. Globally, we are facing a major demographic shift. Today, 8.5% of people worldwide (617 million) are aged 65 and over. By 2050, this percentage is projected to more than double, reaching 1.6 billion. The global population of the oldest oldpeople aged 80 and olderis expected to more than triple between 2015 and 2050, growing from 126 million to 447 million.

At the current pace, population aging is poised to impose a significant strain on economies, health systems, and social structures worldwide. But it doesnt have to.We can envision, just on the horizon, an explosion of potential new medicines, treatments, technologies, and preventive and social strategies that could help transform the way we age and ensure better health, function, and productivity during a period of extended longevity. Multidisciplinary solutions are urgently needed to maximize the number of years lived in good health and a state of well-being. Now is the time to support the next breakthroughs in healthy longevity, so that all of us can benefit from the tremendous opportunities it has to offer.

Register to get updates!

The National Academy of Medicine is launching a Grand Challenge for Healthy Longevity a major initiative to catalyze transformative innovation and inform policies and priorities to advance healthy aging and longevity globally. The initiative will have two components: a series of inducement prizes and awards to stimulate innovation and transform the field; and a comprehensive global roadmap report that will assess the challenges and opportunities of global aging with recommendations for action. The combined objectives of the initiative are to:

The Healthy Longevity Challenge Awards and Prizes will engage innovators, scientists, and entrepreneurs as they compete to catalyze breakthrough discoveries and technologies that will transform the field and stimulate new research and solutions around healthy longevity. The NAM has developed a model of major inducement prizes for breakthrough innovations built on a foundation of catalyst and proof-of-concept awards.

The Challenge will roll out over three distinct phases and employ a tiered model of awards and prizes. Phases 1-2 will prospectively fund new, bold ideas and advance promising research through catalyst and challenge awards respectively. Phase 3 will issue grand prizes to reward the achievement of bold, transformative innovations representing the culmination of previous research.

The Global Roadmap for Healthy Longevity will produce a comprehensive report assessing the challenges presented by global aging and demonstrating how these challenges can be translated into opportunities for societies globally through levers across policy, practice, and socioeconomic infrastructure. The report will be informed by workstreams in three domains: 1) research and innovation; 2) design and operation of healthcare delivery systems; and 3) social, economic, and physical enablers. Across these domains, particular considerations will be given to: policy and practice, health equity and disparities, technology solutions, sustainable financing, and monitoring metrics. The initiative will bring together thought leaders from science, medicine, health care systems, engineering, technology, economics, and policy to identify the necessary priorities and directions for improving health, productivity, and quality of life for older adults worldwide.

Fundraising for the Healthy Longevity Grand Challenge is ongoing. To learn more about the program or ways to get involved, please contact Elizabeth Finkelman at efinkelman@nas.edu.

Register to get updates!

Laura Carstensen of the Stanford Center on Longevity delivers the keynote address at the 2015 NAM Annual Meeting

Innovation in Aging:Victor Dzau, Hal Barron, Joe Coughlin, J. Craig Venter, and Joon Yun

Link:
Grand Challenge for Healthy Longevity - National Academy ...

Endorsements

"Dr. Svoboda literally embodies the wisdom of Ayurveda. He is a spiritual seeker and practitioner of the highest order and lives in that most rare of worlds...one that exists in perfect balance, here mystical and medical become one."

Krishna Das, spiritual vocalist in the bhakti yoga tradition, creator of five CDs including Breath of the Heart, Pilgrim Heart, and Door of Faith, which bring to the West his unique approach to the practice of devotional chanting.

"This book is probably the best of its kind on the market. Ayurveda is one of the best systems for self-healing and the author does not just present an authentic introduction to Ayurveda, but also gives the keys to understand its application in our lives. I recommend it to all my students."

Dr. Swami Shankardevananda, a pioneer in the field of yoga therapy, author of several notable texts on yoga therapy, Australian medical practitioner and international lecturer.

"In this book Dr. Svoboda has beautifully explained the history of Ayurveda, its basic principles and applications in our daily lives. Following these will help to expand the scope of your life, including your mental and physical health as well as longevity. Reflecting Dr. Svobodas Eastern and Western integrative approach to Ayurveda, this book is a practical guide for the student and layperson alike."

Vasant Lad, B.A.M.S., M.A.Sc., Ayurvedic Physician, author of Ayurveda: The Science of Self-Healing, Textbook of Ayurveda, and many others as well as an internationally known teacher, lecturer and founder of The Ayurvedic Institute in Albuquerque, New Mexico.

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Ayurveda: Life, Health, and Longevity: Dr. Robert Svoboda ...

The Longevity Code

Dr. Verburgh tackles age-old questions and arrives at some startling conclusions - with practical suggestions for how to slow down our biological clock.

- Professor Dr. David Ludwig, Harvard University

A brilliant and important book. Kris Verburgh, like no other, is able to represent the complex relationships between nutrition and aging. Recommended for anyone who wants to know what to eat in order to age as healthily as possible.

- Hanno Pijl, MD, PhD, endocrinologist and professor of diabetology at Leiden University Medical Centre, Netherlands

Informative, fascinating, and inspiring... Based on current knowledge, The Longevity Code clearly describes how we ourselves can delay the unwelcome symptoms of aging and presents an extraordinary preview of what the future will bring.

- William Cortvriendt, MD, author of Living a Century or More and Total Health Reset

The Longevity Code summarizes current scientific knowledge of the topic, dispels common and persistent fallacies, and offers perspectives on the future. It does all this in easy-to-read and understandable language.

- Emmy Van Kerkhove, professor emeritus of physiology, Faculty of Medicine and Center for Environmental Sciences, Hasselt University, Belgium

Order online on Amazon,Barnes and Noble,Books a Million, Indigo, Indiebound, Powells, Workman.Order the ebook on iTunes,GooglePlay, Amazon, Kobobooks, Barnes and Noble.Languages: English, Dutch, German, Russian (in preparation), Chinese(in preparation).

Written and developed by Dr Kris Verburgh, this book addresses health and weight loss from a unique new angle, namely the aging process. It debunks many diet myths and introduces a revolutionary new food model, the food hourglass.

The hourglass will show you how to immediately identify what is healthy and unhealthy food, and how to replace unhealthy foods with alternatives. The hourglass helps you lose weight, slow down the aging process and reduce the risk of age-related diseases. Never before has such a food model been developed.

The food hourglassisnt a diet so its easy to start and simple to continue. Just begin eating the right food to see a healthier and thinner you.

PRAISE FOR "THE FOOD HOURGLASS"

In this fluently written book the author critically reveals the link between our genetic determined aging process and our way of eating. Highly recommended for everyone who intends to eat healthier."

- Herman Becq, MD, endocrinologist

Nutrition is an important factor not only in the prevention, but also inthe development of cancer. This book makes you think about habits we take forgranted.

- An Vandebroek, MD, oncologist

The greatest merit of the author is that he provides more depth on nutritional issues in general and in the West. In plain language he brings clarity to thestrongly hyped and advertised topic called nutrition.

- Hans Decoster, MD, cardiologist

Healthy food is our best medicine, as this book shows. If the recommendations of the author are followed, our health care will be more fun and cheaper. Highlyrecommended!

- Adjiedj Bakas, Trendwatcherof the Year and author of'The future of our health''

Languages: Dutch, English, Italian, German, Danish, Russian, Spanish, Polish, Chinese.

Publisher: Houtekiet8th printingFirst release date: 2007Language: DutchNominated for the Eureka Science Prize 2008

Publisher: Athenaeum-Polak & Van GennepFirst release date: 2009Language: Dutch

Publisher: Pandora (pocket), Houtekiet (paperback)4th printing Release date: 2003Language: DutchNominated for the Eureka Science Prize 2004

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Books about health, aging and science - KRIS VERBURGH ...

As futurist and researcher on aging Aubrey de Grey told us about living to 100 and beyond: Aging is the one disease were all born with. Though a magic anti-aging elixir eludes scientists, we spoke with three doctors who go beyond the prescription pad and pill popping to explore root causes, practicing a preventive approach incorporating alternative anti-aging treatments to keep patients feeling healthier longer.

We believe that their approach to longevity is the future of medicine. Get to know them here.

A pioneering figure in alternative/integrative medicine, Dr. Allen founded the La Jolla Clinic of Preventative Medicine and was medical director of the Center for Holistic Health in Solana Beach, California, one of the earliest alternative medical facilities in the United States. At his private practice in Santa Monica, hesearches for the root causes of patients illnesses rather than merely treating symptoms.

When we consider aging, we must look at the beginnings of modern medicine. With the discovery of penicillin and bacteria, the world of medicine changed. There was a certain drug (penicillin) to kill a specific bacteria (strep) and the patient was cured. This one-drug-for-one-disease model has dominated modern medicine, but it is not effective for modern times. We now live to 100 instead of 50, and must deal with dementia, heart disease, stroke, osteoporosis, and cancer. We want to avoid these diseases of modern life and be healthy, fit, sexual, mobile, and pursue our interests and goals as we age. Just as a Ferrari has more reserve than a VW, a 20-year-old has more reserve than an 80-year-old. Lets have 100 healthy, vibrant years and then maybe one bad week at the end.

In order to achieve this goal, we need to look at our lifestyle. Our lifestyle is the information we give to our genes. This is called epigenetics the information we give to our DNA. Diet, stress, exercise, and toxins all affect how our genes express.

Two main areas I see in my patients are stress in their lives and toxicity in their bodies. High cortisol levels kill brain cells; wreak our immune system; and predispose us to dementia, heart disease, and low energy. Adding daily meditation, exercise, and getting adequate sleep can help lower our stress levels. I test mercury, lead, and other toxins in most of my patients. Many have high mercury levels from fish intake. Increased body burden of mercury can show up as fatigue, autoimmune disease, and brain fog. The No. 1 problem that patients come to doctors for is fatigue, but mercury levels are rarely checked. We need to lower the toxins in our bodies. Detoxification with diet, sauna, and intermittent fasting can all be helpful. I like to do a detox at the change of the seasons four times a year.

In my practice, Im not just treating illnesses but showing patients how they can be healthy longer. Some just want to stay healthy, others want to balance hormone levels, and others come with problems that have not be previously solved. Its like a tree: If we treat the roots of the tree, all the branches begin to blossom. We do need specialists, but the different branches of modern medicine have often become too isolated from each other. As I learned when I studied Oriental medicine, you cannot separate the body from the mind.

I want to treat people so they feel better. We must get away from the idea that a doctor can give you a magic pill that will take care of everything. Its about lifestyle and taking responsibility for your health. Doctor and patient should collaborate, with the doctor as a coach. Of course that means the patients needs to be coachable.

I had a patient, one of the richest men in the United States, who had a heart attack that left him unable to walk across the room. He said he would give up all his wealth just to get his health back. Id like to challenge everyone to make it a year of the best mental and physical health of your life to make the changes in your life to make this happen.

Learn more about Dr. Allen atdavidallenmd.com.

Left to right: Dr. David Allen, Dr. Constantine Kotsanis, Dr. Patricia Deckert

Dr. Deckert began her private practice in 2001 with the goal of educating, guiding, and empowering people to maintain or restore their health. Rather than just treating disease, she works to decrease the risk of future health problems and maximize wellness withcutting-edge research, the best of conventional medicine, and nutrition and lifestyle medicine.

You have to consider the big picture. I always look at the patient and ask, Where are they in the continuum of health, vigor, and vitality? And how do we move them to a greater level of wellness in the aging/anti-aging equation towards the vitality end of the continuum? Most of us are carrying around weak links. But it takes time and sitting and listening to help people live their healthiest, because the most we learn about patients is from what they tell us, not just their medical file. I think increasingly women, in particular, understand that a big first step to their wellness and longevity is finding a doctor who cares about them as a person and gives the time to consider new approaches and treatments.

I particularly look at stress and cortisol levels big issues for women that can have an extreme impact on aging. And I put a lot of focus on gut issues, because the gut is so very important to overall wellness. The largest interface to the world is through our GI tract. We have more cells of flora in our gut than cells in our body. Having a gut analysis, looking at what organisms live there and what pathways need supporting, is something I believe all women (and men) should have done. Its important, also, to look at genetic analysis and look at pathways supporting inflammation and detoxification, as both can create unhealthy aging issues.

Women also critically need support for their hypothalmic pituitary adrenal axis and where theyre at hormonally, which can do a number on how we feel and function. So we look at does a patient need more estrogen or are they poor estrogen detoxifiers? Traditional practice only checks TSH (thyroid-stimulating hormone) for thyroid function health, which is the poorest way. We need to look at all aspects of adrenal, thyroid, and cortisol function. Most physicians today are not being taught to assess and treat that. You also have to step back and look at the whole bodys health and functioning, including our musculoskeletal system beyond chiropractic adjustments. Muscle and tendon health and stretching is so important for women as we age.

There are exciting new treatments happening, and Im always researching the latest alternative treatments and got excited about ozone, which has three oxygen atoms that all our tissues need to help activate the immune system and optimize the bodys use and intake of oxygen. Im seeing highly beneficial results from ozone therapy injected for pain trigger points or piped into the ears in gas form to support tissue health for a variety of issues. I got interested in salt therapy, too, for various respiratory issues, as I have allergies myself and sitting in a salt chamber is naturally therapeutic, like going to the ocean.

Im a big believer in supplements, which traditional medicine ignores. Its overwhelming for a woman walking into a GMC or Whole Foods, so its important to find help knowing what you need and getting high-quality products. I have a supplement area in my office to support my holistic practice, that way I can talk them through what I think they need including, many times for women, CBD. We have an endocannabinoid system [found to be important in regulating mood, physiology, and general well-being], and in my experience CBD is especially helpful for anxiety, sleep, and pain.

Right now Im getting excited about the disease management and anti-aging possibilities of stem cells and using not just our own or cord stem cells but CGF (concentrated growth factor), which contains stem cell materials but is not so expensive.

I believe alternative approaches are beneficial and necessary for living longer. Im a primary care physician and prescribe meds, which are still important for disease and health management, but Ive always believed that new and alternative modalities are vital to a long life.

Learn more aboutDr. Patricia Deckert atmdvip.com.

Born in Greece and raised in Chicago, Dr. Kotsanis is a board-certified otolaryngologist and certified in clinical nutrition. At his privatepractice in Texas, he focuses on wellness and anti-aging. He uses an integrative approach to treat patients for everything from allergies to cancer, carefully considering each persons unique physical, metabolic, and biochemical makeup.

Anti-aging is a catch-all phrase. People expect longevity, which is wonderful. But what good is longevity if youre not healthy?You have to add life into your years and years into your life. Ideally all our systems are fine-tuned and working, so we look at why they break down find out what went wrong and fix the broken problem. So my approach is first to look at the lay of the land of your health to identify whats broken, and my work-up is extensive and very specific.

Its most important to look at the brain, which controls everything, physical and emotional. Fifty percent of all the problems in the world are emotional. We use chromatotherapy, in which a psychologist works with color therapy to regress a person all the way back to when they were born. A lot of health and emotional issues have been forgotten, so lots of tears fly and a lot is learned.

We look at hormones, which are key players in our health to help women feel healthier. Insulin is the most important hormone in the body, so we need to fix any insulin resistance. Right now Im working on research for how to reverse insulin resistance. Its such a huge issue. Insulin is a hormone that controls your metabolism, your energy, and emotions, not just sugar. If we can reverse insulin resistance it can help with hundreds of diseases. Insulin is underplayed. Its super gasoline for the body! I look at cortisol resistance and normalize electrolytes, also.

A healthy digestive system is one key for lifelong health your 28 feet of gut are an important part of the immune system. If your mouth is full of crowns and fillings, it impacts the gut. Looking at the electromagnetic fields is also important. Compare the human body to a car: You need gasoline to make it run but you also need a battery. Its biophysics; we need a certain voltage to maintain cell health, which drops when we are sick. We treat deficiencies with supplements and intravenous infusions that correct the bodys electrolyte imbalances and use microcurrent technology Tesla technology! with a handheld microcurrent device the size of a mouse to jump-start electricity to help boost energy, sleep, hormones, and much more. Removing toxicity from the body is also very important to adding life to your years.

And then what you have to do is be happy, maintaining a continuous mind-body-spirit connection. Have happy thoughts; watch funny movies; meditate and pray every day; and have good friends. We completely neglect our emotions. But the absence of disease does not equal health: Vibrant health means enjoying your life. At the end of the day, everybodys mortal. But my approach is: How can I help you live to 100 and feel like 40? You also have to be an engaged patient. Its like the joke how many psychiatrists does it take to change a lightbulb? One, as long as the lightbulb wants to change.

Learn more about Dr.Constantine Kotsanis atkotsanisinstitute.com.

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Longevity Medicine - Integrative Medical Doctors | The ...

Spinal Muscular Atrophy MedicineMarket 2020: Inclusive Insight

Los Angeles, United States,June 2020:The report titled Global Spinal Muscular Atrophy Medicine Market is one of the most comprehensive and important additions to Alexareports archive of market research studies. It offers detailed research and analysis of key aspects of the global Spinal Muscular Atrophy Medicine market. The market analysts authoring this report have provided in-depth information on leading growth drivers, restraints, challenges, trends, and opportunities to offer a complete analysis of the global Spinal Muscular Atrophy Medicine market. Market participants can use the analysis on market dynamics to plan effective growth strategies and prepare for future challenges beforehand. Each trend of the global Spinal Muscular Atrophy Medicine market is carefully analyzed and researched about by the market analysts.

Spinal Muscular Atrophy Medicine Market competition by top manufacturers/ Key player Profiled: Astellas Pharma Inc.AveXis, Inc.Bioblast Pharma Ltd.Cytokinetics, Inc. 24F. Hoffmann-La Roche Ltd.GenethonGenzyme CorporationGMP-Orphan SASIonis Pharmaceuticals, Inc.Longevity Biotech, IncNeurodyn Inc.Neurotune AGNovartis AGSarepta Therapeutics, Inc.Voyager Therapeutics, Inc.Vybion, Inc.WAVE Life Sciences Ltd.

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Global Spinal Muscular Atrophy Medicine Market is estimated to reach xxx million USD in 2020 and projected to grow at the CAGR of xx% during 2020-2026. According to the latest report added to the online repository of Alexareports the Spinal Muscular Atrophy Medicine market has witnessed an unprecedented growth till 2020. The extrapolated future growth is expected to continue at higher rates by 2026.

Spinal Muscular Atrophy Medicine Market Segment by Type covers: LMI-070, ND-602, NT-1654, Nusinersen, NXD-30001

Spinal Muscular Atrophy Medicine Market Segment by Application covers:Hospital, Clinic

After reading the Spinal Muscular Atrophy Medicine market report, readers get insight into:

*Major drivers and restraining factors, opportunities and challenges, and the competitive landscape*New, promising avenues in key regions*New revenue streams for all players in emerging markets*Focus and changing role of various regulatory agencies in bolstering new opportunities in various regions*Demand and uptake patterns in key industries of the Spinal Muscular Atrophy Medicine market*New research and development projects in new technologies in key regional markets*Changing revenue share and size of key product segments during the forecast period*Technologies and business models with disruptive potential

Based on region, the globalSpinal Muscular Atrophy Medicine market has been segmented into Americas (North America ((the U.S. and Canada),) and Latin Americas), Europe (Western Europe (Germany, France, Italy, Spain, UK and Rest of Europe) and Eastern Europe), Asia Pacific (Japan, India, China, Australia & South Korea, and Rest of Asia Pacific), and Middle East & Africa (Saudi Arabia, UAE, Kuwait, Qatar, South Africa, and Rest of Middle East & Africa).

Key questions answered in the report:

What will the market growth rate of Spinal Muscular Atrophy Medicine market?What are the key factors driving the global Spinal Muscular Atrophy Medicine market size?Who are the key manufacturers in Spinal Muscular Atrophy Medicine market space?What are the market opportunities, market risk and market overview of the Spinal Muscular Atrophy Medicine market?What are sales, revenue, and price analysis of top manufacturers of Spinal Muscular Atrophy Medicine market?Who are the distributors, traders, and dealers of Spinal Muscular Atrophy Medicine market?What are the Spinal Muscular Atrophy Medicine market opportunities and threats faced by the vendors in the global Spinal Muscular Atrophy Medicine industries?What are sales, revenue, and price analysis by types and applications of Spinal Muscular Atrophy Medicine market?What are sales, revenue, and price analysis by regions of Spinal Muscular Atrophy Medicine industries?

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Table of ContentsPart I Spinal Muscular Atrophy Medicine Industry OverviewChapter One Spinal Muscular Atrophy Medicine Industry Overview1.1 Spinal Muscular Atrophy Medicine Definition1.2 Spinal Muscular Atrophy Medicine Classification Analysis1.2.1 Spinal Muscular Atrophy Medicine Main Classification Analysis1.2.2 Spinal Muscular Atrophy Medicine Main Classification Share Analysis1.3 Spinal Muscular Atrophy Medicine Application Analysis1.3.1 Spinal Muscular Atrophy Medicine Main Application Analysis1.3.2 Spinal Muscular Atrophy Medicine Main Application Share Analysis1.4 Spinal Muscular Atrophy Medicine Industry Chain Structure Analysis1.5 Spinal Muscular Atrophy Medicine Industry Development Overview1.5.1 Spinal Muscular Atrophy Medicine Product History Development Overview1.5.1 Spinal Muscular Atrophy Medicine Product Market Development Overview1.6 Spinal Muscular Atrophy Medicine Global Market Comparison Analysis1.6.1 Spinal Muscular Atrophy Medicine Global Import Market Analysis1.6.2 Spinal Muscular Atrophy Medicine Global Export Market Analysis1.6.3 Spinal Muscular Atrophy Medicine Global Main Region Market Analysis1.6.4 Spinal Muscular Atrophy Medicine Global Market Comparison Analysis1.6.5 Spinal Muscular Atrophy Medicine Global Market Development Trend AnalysisChapter Two Spinal Muscular Atrophy Medicine Up and Down Stream Industry Analysis2.1 Upstream Raw Materials Analysis 2.1.1 Proportion of Manufacturing Cost 2.1.2 Manufacturing Cost Structure of Spinal Muscular Atrophy Medicine Analysis2.2 Down Stream Market Analysis2.2.1 Down Stream Market Analysis2.2.2 Down Stream Demand Analysis2.2.3 Down Stream Market Trend AnalysisPart II Asia Spinal Muscular Atrophy Medicine Industry (The Report Company Including the Below Listed But Not All) Chapter Three Asia Spinal Muscular Atrophy Medicine Market Analysis3.1 Asia Spinal Muscular Atrophy Medicine Product Development History3.2 Asia Spinal Muscular Atrophy Medicine Competitive Landscape Analysis3.3 Asia Spinal Muscular Atrophy Medicine Market Development TrendChapter Four 2015-2020 Asia Spinal Muscular Atrophy Medicine Productions Supply Sales Demand Market Status and Forecast4.1 2015-2020 Spinal Muscular Atrophy Medicine Production Overview4.2 2015-2020 Spinal Muscular Atrophy Medicine Production Market Share Analysis4.3 2015-2020 Spinal Muscular Atrophy Medicine Demand Overview4.4 2015-2020 Spinal Muscular Atrophy Medicine Supply Demand and Shortage4.5 2015-2020 Spinal Muscular Atrophy Medicine Import Export Consumption4.6 2015-2020 Spinal Muscular Atrophy Medicine Cost Price Production Value Gross MarginChapter Five Asia Spinal Muscular Atrophy Medicine Key Manufacturers Analysis5.1 Company A5.1.1 Company Profile5.1.2 Product Picture and Specification5.1.3 Product Application Analysis5.1.4 Capacity Production Price Cost Production Value5.1.5 Contact Information5.2 Company B5.2.1 Company Profile5.2.2 Product Picture and Specification5.2.3 Product Application Analysis5.2.4 Capacity Production Price Cost Production Value5.2.5 Contact Information5.3 Company C5.3.1 Company Profile5.3.2 Product Picture and Specification5.3.3 Product Application Analysis5.3.4 Capacity Production Price Cost Production Value5.3.5 Contact Information5.4 Company D5.4.1 Company Profile5.4.2 Product Picture and Specification5.4.3 Product Application Analysis5.4.4 Capacity Production Price Cost Production Value5.4.5 Contact InformationChapter Six Asia Spinal Muscular Atrophy Medicine Industry Development Trend6.1 2020-2024 Spinal Muscular Atrophy Medicine Production Overview6.2 2020-2024 Spinal Muscular Atrophy Medicine Production Market Share Analysis6.3 2020-2024 Spinal Muscular Atrophy Medicine Demand Overview6.4 2020-2024 Spinal Muscular Atrophy Medicine Supply Demand and Shortage6.5 2020-2024 Spinal Muscular Atrophy Medicine Import Export Consumption6.6 2020-2024 Spinal Muscular Atrophy Medicine Cost Price Production Value Gross MarginPart III North American Spinal Muscular Atrophy Medicine Industry (The Report Company Including the Below Listed But Not All)Chapter Seven North American Spinal Muscular Atrophy Medicine Market Analysis7.1 North American Spinal Muscular Atrophy Medicine Product Development History7.2 North American Spinal Muscular Atrophy Medicine Competitive Landscape Analysis7.3 North American Spinal Muscular Atrophy Medicine Market Development TrendChapter Eight 2015-2020 North American Spinal Muscular Atrophy Medicine Productions Supply Sales Demand Market Status and Forecast8.1 2015-2020 Spinal Muscular Atrophy Medicine Production Overview8.2 2015-2020 Spinal Muscular Atrophy Medicine Production Market Share Analysis8.3 2015-2020 Spinal Muscular Atrophy Medicine Demand Overview8.4 2015-2020 Spinal Muscular Atrophy Medicine Supply Demand and Shortage8.5 2015-2020 Spinal Muscular Atrophy Medicine Import Export Consumption8.6 2015-2020 Spinal Muscular Atrophy Medicine Cost Price Production Value Gross MarginChapter Nine North American Spinal Muscular Atrophy Medicine Key Manufacturers Analysis9.1 Company A9.1.1 Company Profile9.1.2 Product Picture and Specification9.1.3 Product Application Analysis9.1.4 Capacity Production Price Cost Production Value9.1.5 Contact Information9.2 Company B9.2.1 Company Profile9.2.2 Product Picture and Specification9.2.3 Product Application Analysis9.2.4 Capacity Production Price Cost Production Value9.2.5 Contact Information

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2020 Current trends in Spinal Muscular Atrophy Medicine Market Estimated To Experience A Hike in Growth | Global Industry Size, Growth, Segments,...

As medical instruments and technologies grow more sophisticated and complex, it is increasingly important to guard sensitive components from the autoclaving process while supporting their longevity. Glass offers a solution.

Jochen Herzberg, Schott Electronic Packaging

Autoclavable glass-sealed connector from Schott [Image courtesy of Schott Electronic Packaging]

Implementation of high-quality connectors using the right materials is crucial. Inferior components can weaken the protection of the devices electronics. Glass-to-metal sealing technology, already used in other harsh-environment applications such as aviation, aerospace and automotive safety, has emerged as an ideal solution in the development and manufacture of medical connectors. Glass-to-metal sealed connectors offer a resilient and dependable option that remains reliably gas-tight for over 3,500 autoclaving cycles, subsequently helping extend the lifespan of medical devices.

Many medical connectors are sealed with polymers or epoxy resins, which are not capable of maintaining a dependable seal over a long period. During the autoclaving process and especially after repeated cycles, polymer-based connectors will allow for a certain permeability of moisture. This can cause damage to electronic components. The binders and chemicals that make up polymer seals deteriorate over time, leaving a brittle shield incapable of providing truly reliable protection from autoclaving conditions.

The aging process and breakdown of these organic materials can happen quickly, sometimes after as few as 100 autoclaving cycles. The potential inability of polymer seals to stand up to the fundamentally important autoclaving process can lead to a plethora of problems: shortened device lifespan, failure during a procedure and increased total cost of ownership from compromised seal integrity.

A common argument against glass as a material is the idea that it is easily broken. Glass-to-metal sealing technology challenges this concept. Using advanced manufacturing processes, the glass preform and metal pieces are heated to a temperature that melts the glass, fusing glass and metal to create a gas-tight and pressure-proof seal.

During their use, glass seals maintain integrity because glass is inorganic and non-aging. It is non-porous and resistant to drastic environmental changes. This makes it a choice material to use in the manufacture of medical connectors because it has a proven ability to withstand the autoclaving process more than 3,500 times. The strong seal effectively prevents the ingress of moisture and other outside contaminants, safeguarding electronics from damaging humidity and particulates.

Confidence is of the utmost importance in medicine. A doctors confidence in his abilities, decisions, colleagues and treatment all come together in the effort to create a successful patient outcome. The same need for confidence applies to medical devices. Medical professionals must be able to have trust in their equipment. The use of devices with glass-to-metal sealed connectors goes a long way to help establish this on many fronts.

Cross-contamination incidents are one of the most substantial threats to patient safety and professional integrity in the medical industry. Mitigating the risk of such incidents is why the autoclaving process is extremely important in medical environments. Traditionally, steam sterilization presents a major strain on devices because it can accelerate wear on components. With protection for electronics from glass-to-metal connectors, devices can undergo a complete and intensive autoclaving cycle over 3,500 times without risk of accelerated damage or wear on the electronics.

Increased reliability aided by the use of glass-to-metal connectors eases worry both in the operating room and finance office. Glass-to-metal connectors can help extend device service life, reduce maintenance costs, and lessen the chance of warranty claims and physician frustrations. Surgeons and patients can experience the safety benefit of a decreased chance of device failure, while hospital budgets can experience a reduced burden thanks to a less-frequent device replacement schedule.

Versatility is another key benefit that sets glass-to-metal sealed connectors apart in a constantly developing medical landscape. Integration possibilities for medical applications include surgical tools, endoscopes or instruments for spectrometry and pulse oximetry. Customization possibilities can be met for individual and exact application needs, enabling design flexibility for medical device engineers. This creates the opportunity to conceptualize distinct ideas while still meeting strict regulatory requirements for medical devices.

Glass-to-metal sealed medical connectors can be custom-designed in a number of ways, including varying shapes, sizes and pin configurations to match requirements for integration in medical devices that require power and data supply and must be repeatedly autoclaved.

Devices and techniques will change, but the rigid standards for autoclaving requirements for hygienic operating rooms will remain a constant. As medical instruments and technologies grow more sophisticated and complex, it is increasingly important to guard sensitive components from the autoclaving process while supporting their longevity. Glass, in its distinct role as an inorganic and reliable sealing material, offers a way.

Jochen Herzberg is an innovation leader at Schott Electronic Packaging in Landshut, Germany.

(See the best minds in medtech live at DeviceTalks Boston on Oct. 2.)

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How glass-sealed connectors increase medical device longevity - Medical Design & Outsourcing

The Tourism Authority of Thailand is holding the Amazing Thailand Health and Wellness Showcase 2017 to encourage Thailand's health tourism business in order to demonstrate the potentiality and readiness of health service products of Thailand at an international level, in order to create opportunities for health service providers of Thailand. Sellers can meet health tourism business representatives, buyers and media from all over the world to introduce Thailand's products and services to sales representatives worldwide.

Bangkok, Thailand (PRWEB) August 19, 2017

Mr. Noppadon Pakprot, Deputy Governor for Tourism Products and Business, Tourism Authority of Thailand presided over the Amazing Thailand Health and Wellness Tourism Showcase 2017 yesterday, which unveiled the latest "Functional & Regenerative Medicine" innovation in Thailand.

Mr. Noppadon Pakprot, Deputy Governor for Tourism Products and Business at TAT said, "Thailand has long been recognized as a world destination for medical tourism. According to a report by VISA and Oxford Economics, Thailand has once more been confirmed as one of Asia's top medical tourism destinations. Thailand now has 58 JCI-accredited hospitals, more than any other Southeast Asian country."

The Amazing Thailand Health and Wellness Tourism Showcase 2017, under the concept "Thailand: a Paradise for Longevity", showcased Thailand as a destination for longevity products and services.

Thailand has adopted the latest innovative medicine of the century: "Functional & Regenerative Medicine," the most popular health trend in the world. In fact, Thailand is the first and only country in Asia that has specialized Functional & Regenerative Medicine hospitals, namely Better Being Hospital and MALI hospital

Moreover, Thailand has become an anti-aging center in Asia with the largest number of American Academy of Anti-Aging Medicine-certified medical professionals in Asia with 500 doctors.

"Recently, the government implemented new medical tourism policies extending the visitor stay period to 90 days for members of CLMV countries and Republic of China in order to accommodate medical tourists traveling to Thailand. In addition, the long-stay visa has also been extended to 10 years for 14 countries as follow: Japan, Australia, Denmark, Finland, France, Germany, Italy, Netherlands, Norway, Sweden, Switzerland, UK, Canada and the U.S. These two recent policies should further enhance the positioning of Thailand to be a world-class medical tourism hub recognized the world over."

Mr. Noppadon noted: "This is the 4th such event that TAT has organized, and this year we proudly present the top 44 Health and Wellness providers in Thailand. This event will display the potential of Thailand along with its plethora of health and wellness products to international awareness. It will also provide a marketing platform for Thai health and wellness providers to discuss prospective business deals with medical tourism facilitators and travel agencies from across the globe."

The one-day event highlighted why Thailand is a "Paradise for Longevity", along with holding an informative presentation on the concept of "Functional & Regenerative Medicine." In the afternoon, buyers had the chance to discuss business deals with the top 44 health and wellness provider in Thailand, including: General Hospital, Plastic Surgery Hospital, Regenerative Functional Medicine Hospital, Anti-Aging Clinic, Cosmetic & Aesthetic Clinic, Dental Clinic, Cell Therapy Clinic, and Lab Check Up, all of whom were ready to discuss prospective business deals with international buyers.

Mr. Noppadon Pakprot concluded as follows: "We hope that this event will further strengthen the awareness of Thailand as the premier destination for health and wellness tourism, and that the trade event would help generate more than 500 millions Baht to the Thai economy."

Ms. Jittima Udayachalerm, Director, Royal Orchid Plus Business Unit said, "Royal Orchid Plus is delighted to be part of this global medical tourism event at this time. We've created exciting marketing activities to support this project. We've organized a special event, inviting Royal Orchid Plus Platinum and Gold members to come and get health check-ups for free, and also given them the chance to meet and buy special packages from the hospitals and clinics at the event. Additionally, we will promote an exclusive health and wellness deal to Royal Orchid Plus members through our online channels, including email, social media, and our website."

For the original version on PRWeb visit: http://www.prweb.com/releases/ThailandHealthWellness/2017/prweb14612783.htm

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TAT Holds Global Medical Tourism Event: "Amazing Thailand Health and Wellness Tourism Showcase 2017 ... - Benzinga

Life expectancy graphs provide much cause for optimism in 2020, especially if you trace it back to when records first began. The steep rise in global life expectancy over the last few decades paints a particularly pleasing picture. The upward trend can in part be attributed to pioneering research in the field of science and medicine, which continues to add further weight to universally accepted truths, such as the importance of eating a healthy, balanced diet to stave off the risk of developing life-threatening complications.

Another truism that has been supported by rigorous research is that going on holiday is good for your health.

According to a 40-year study published in the The Journal of Nutrition, Health & Aging, vacationing can extend your lifespan.

To support this hypothesis, researchers analysed data on 1,222 middle-aged male executives born in 1919 to 1934 and recruited into the Helsinki Businessmen Study in 1974 and 1975.

Participants had at least one risk factor for cardiovascular disease (smoking, high blood pressure, high cholesterol, elevated triglycerides, glucose intolerance, overweight).

READ MORE:Best supplements for heart health: Four supplements to ensure a healthy heart

Participants were randomised into a control group (610 men) or an intervention group (612 men) for five years.

The intervention group received oral and written advice every four months to do aerobic physical activity, eat a healthy diet, achieve a healthy weight, and stop smoking.

When health advice alone was not effective, men in the intervention group also received drugs recommended at that time to lower blood pressure (beta-blockers and diuretics) and lipids (clofibrate and probucol).

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Men in the control group received usual healthcare and were not seen by the investigators. As previously reported, the risk of cardiovascular disease was reduced by 46 percent in the intervention group compared to the control group by the end of the trial. However, at the 15-year follow-up in 1989 there had been more deaths in the intervention group than in the control group. The surprising finding prompted the researchers to do some deeper digging, which revealed that shorter vacations were associated with excess deaths in the intervention group.

In the intervention group, men who took three weeks or less annual vacation had a 37 percent greater chance of dying in 1974 to 2004 than those who took more than three weeks.

Accounting for the findings, Professor Timo Strandberg, of the University of Helsinki, Finland, said: "The harm caused by the intensive lifestyle regime was concentrated in a subgroup of men with shorter yearly vacation time.

In our study, men with shorter vacations worked more and slept less than those who took longer vacations.

He continued: This stressful lifestyle may have overruled any benefit of the intervention. We think the intervention itself may also have had an adverse psychological effect on these men by adding stress to their lives."

Professor Strandberg concluded: "Our results do not indicate that health education is harmful. Rather, they suggest that stress reduction is an essential part of programmes aimed at reducing the risk of cardiovascular disease.

Lifestyle advice should be wisely combined with modern drug treatment to prevent cardiovascular events in high-risk individuals."

According to the American Heart Association, stress may affect behaviours and factors that increase heart disease risk, such as high blood pressure, cholesterol levels, smoking, physical inactivity and overeating.

Some people may choose to drink too much alcohol or smoke cigarettes to manage their chronic stress, however these habits can increase blood pressure and may damage artery walls, it adds.

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How to live longer: Find time in your year to do this to extend your lifespan - Express

Therapy using light has accumulated some convincing science. This has led us to think that it could be a very healthy kind of drug, which is why its getting more popular in the wellness sphere. It sounds a bit crazy. However, weve got reasons to believe that light therapy might help prevent the aging process. As you know, marketing and anti-aging gimmicks are not uncommon. Especially when theres more money to be made.

Weve got to be careful about the kind of therapy we choose. There are many new companies promising the amazing effects of sitting under a small panel of red lights. But are these claims true and does light therapy work? Supposedly light therapy can help improve sleep and athletic performance, and speed up muscle recovery and joint repair. If this is true, then light therapy is a good way to go. Its said to increase melatonin production and promote a healthy circadian rhythm. Better yet, it may even be able to improve skin quality because it can reduce inflammation and increase collagen production. Wow!

Interestingly, this kind of therapy is becoming quite mainstream too. In fact, these kinds of treatments are not just found in spas, gyms or dermatologists offices. These gadgets are affordable for the average consumer, like you and I. The question remains, what does it do and does it work? Theres research about these new treatments coming out of our ears. Studies today show how light therapy can heal the brain and body of just about anything and everything. Perhaps its just the light we need in general? Either way, we are very intrigued.

This treatment is usually conducted using a line of red lights. You are meant to expose yourself to them for a certain amount of time to get the benefits. There are some may home-versions available nowadays too. Experts call this treatment light therapy, photo medicine, or photobiomodulation. Its based on the idea that light can change us on a cellular level.

New studies have even made jokes about the treatment since it seems kind of obvious. Just get more sunshine guys! Just like plants, we too need more light to thrive. However, there might be more to it than that. Lets take a closer look. It seems logical that light could help improve ones skin. Think about babies with yellow jaundice and how they need to sit under a light to heal their skin. Or when you sit in the sun, you tan or get burnt if done without sunblock. Then theres those who experience seasonal depression. Apparently light technology can help lift their mood and reduce the effects of depression. So, theres definitely some truth in the theory.

The part that gets us is how does light help somebody with diabetes? It also doesnt explain how certain studies related light therapy to improve neurological problems. These include Alzheimers and even traumatic brain injuries. Light and neurology? How do they connect? Theres no doubt that vitamin D from the sun is good for our skin, but how would light therapy alter or improve the skin? Were talking epic results like reducing wrinkles and acne. Perhaps were more like plants than we thought.

The treatment uses different kinds of light, from invisible, near-infrared light through the visible-light spectrum (red, orange, yellow, green, and blue). However, the light stops before you get exposed to harmful ultraviolet rays. Studies seem to have only covered the effects of red and near-infrared light. Apparently red light is often used to treat skin conditions. Then near-infrared allows you to penetrate much deeper, so it can work its way through skin and bone and even into the brain. How amazing is that?

Then you get a blue light. Researchers believe this light therapy is brilliant at treating infections and can help treat acne. The effects of green and yellow light are less understood. However, green light might improve hyper pigmentation, and yellow light might reduce photoaging. When it comes to sunlight, people have used it as a means of healing for centuries. People believe that it can help cure diseases and destroy bacteria. So light therapy is nothing new to us. Even astronauts who experienced wounds and exposed themselves to LED lights were able to heal quicker than those without light. So theres a lot we dont understand yet about tissue repair.

Scientists are fascinated by the healing potential of light therapy. In fact, other studies discovered that people who exposed themselves to blue light improved their depression. They also experienced a reduction in other concussion symptoms including sleep disturbance, fatigue, concentration, restlessness, and irritability.

The technology today is incredible. We are able to complete treatments like light therapy in the comfort of our own homes. Some of these gadgets are small enough to keep on your bedside table. You can complete targeted treatments for your face, joints, and muscles, or one at a time.

Apparently theyre not hot to touch either. They are room temperature. Yet after a few minutes of sitting in front of them, you feel warm. The theory says that this is your cells, heating you from the inside out. I suppose its very similar to a day out in the sun, just without the skin damage. Apparently light therapy is also effective for reducing the appearance of scars.

Light therapy scientists say that they arent exactly certain of how the mechanism works. However, they know that light sparks a cellular response because our cells respond to light. In addition, scientists think that red and near-infrared light interacts with something called cytochrome c oxidase, or CCO. This is a photosensitive enzyme found within the mitochondria. This enzyme is light that basically gives the mitochondria a little kick in the pants. Scientists dont know if the mitochondria favors this zap of light. However, it does tell the cell to start making the proteins that will protect it and make it healthier.

Essentially when CCO finds the light, it converts it to energy. It then uses that energy to do whatever that cell is supposed to do, only more efficiently. SO instead of applying expensive creams every day, this light is meant to help you protect your skin naturally.

Experts state that mitochondria and chloroplasts in plants are basically evolutionary kissing cousins. Chloroplasts absorb light and make energy for plants during photosynthesis, and our mitochondria convert light to energy in a similar way. So youre not a plant, but your cells behave very similarly to a plant.

As confusing and complicated as the treatment is.

We all need to pause for a moment because its the most obvious concept around. We need light to survive and thrive.

Take time to ensure youre getting the basics to healthy living before thinking of everything else. Dont overlook the basics of being human. Water is good, sleep is good, socializing with friends is good, alcohol is not always so good. Light is good.

Whilst theres no doubt that getting lots of light is beneficial for our health. Try not to fall victim to marketing tactics that claim the yellow or green light will do magical things. The science just isnt there yet. Theres nothing wrong with a bit of scepticism. A lot of these concepts are just based on theories. The problem with wellness fads is that they often blur the lines between the science of photo medicine and light therapy gimmicks.

You know how it goes, ancient natural practices are always better than modern ones. It makes sense as to why light therapy would be so much more popular now. These theories do have some truth and even celebrities like Shailene Woodley are claiming the benefits of exposing yourself to more light. There is some evidence that blue light can destroy fungi likeCandida albicans, which can cause yeast infections. This is particularly important for those who live in cold or winter climates.

There is also a massive shift in mindset patterns. A lot of youngsters are feeling distressed about climate change. Were seeing an increase in environmental anxiety and not knowing what to do to prevent the end of the planet. Some are fearing that we might not even be able to live in a world where it is safe to go outside. No wonder light therapy is getting so popular. Smoke and dust storms from wildfires have caused heart disease, lung disease, and even premature death.

So the thought of a future indoors terrifies many of us. Its no surprise there that were revelling at the opportunity for new technologies to use artificial light therapy to help us heal. More science is required to decide whether light therapy truly works.

Nobody stops to think twice about the fact that they can eat berries in January or avocado on toast every day of the year. In reality, this isnt how its supposed to work, and were not really meant to be eating fruits and vegetables when theyre not in season. This is why.

Light Is My New Drug The Actually Convincing Science Of Light Therapy. The Cut. https://www.thecut.com/2020/03/does-light-therapy-work.html

Best Beauty Tools And Gadgets In 2020: Nuface, Foreo And More. CNET. https://www.cnet.com/news/best-beauty-tools-gadgets-2020-nuface-foreo/

Can Light Therapy Help Improve Mood In People With Concussion? Science Daily. https://www.sciencedaily.com/releases/2020/03/200302162250.htm

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Therapy From The Light Might Be The Best Kind Of Drug - Longevity LIVE

XconomySan Francisco

Cell therapies have reached the market as a new treatment option for some cancers. But the scientists of Sonoma Biosciences say this approach also holds promise for autoimmune disorders, and the biotech startup has unveiled $40 million in financing to develop its technology.

The investors in Sonomas Series A round of funding include Lyell Immunopharma, ARCH Venture Partners, Milky Way Ventures, and 8VC.

Cell therapy involves removing a patients immune cells, engineering them, and then infusing them back into the patient to perform their therapeutic tasks. The cancer cell therapies that have been approved by the FDA are made by engineering T cells, the frontline defenders of the immune system.

Sonoma, which splits its operations between South San Francisco and Seattle, is working with a different immune cell called a regulatory T cell (Treg). Whereas T cells target pathogens, Tregs target other immune cells, suppressing excessive immune responses, CEO and co-founder Jeff Bluestone tells Xconomy. Research by Sonomas scientific co-founders uncovered evidence, in studies in mice and humans, that the absence of these cells sparked the development of some autoimmune diseases. Those diseases led to death in about one year without a bone marrow transplant, Bluestone adds.

Sonoma is developing Treg therapies intended to shut down unwanted immune responses. The approach involves harvesting these cells from patients and engineering them with features that make them stable, durable, and targeted specifically to the site of inflammation. Those cells would then be infused into the patient to stop the autoimmune response. Bluestone says its too soon to talk about a lead disease target, but he adds that this approach has potential applications in rheumatoid arthritis, inflammatory bowel disease, and multiple sclerosis.

The hope is that a Sonoma cell therapy is a one-time treatment. Bluestone says that because these therapies are cells that multiply, they should survive in the patient on standby until theyre needed again to address an autoimmune response.

Theres another feature that could contribute to the longevity of a Treg treatment. When these cells shut down an autoimmune response, they influence other cells in the vicinity to join in, Bluestone explains. By educating these other cells to take up this immunosuppressive role, Bluestone says the effect of these therapies could be long lasting. But he cautions that the durability of a Treg therapy wont be known until more tests are done in humans.

Bluestones knowledge about Tregs stems from his own research. He and another Sonoma co-founder, Qizhi Tang, studied Tregs at the University of California, San Francisco, for 12 years. Their research included diabetes, organ transplantation, and lupus, among other conditions. That work led to small patient studies testing the technology for safety.

In addition to his UCSF research, Bluestone was the president and CEO of the Parker Institute for Cancer Immunotherapy. Over the course of a career that has bridged academia and industry, Bluestones immunology research has led to the development and commercialization of immunotherapies for organ transplants and cancer. He says he is joining Sonoma now because theres only so far that you can get in an academic lab if you want to impact peoples lives. Cell therapy could be the next major medicine for humans, he adds, and he wants to be involved as part of a company developing these treatments.

The other co-founders are Chief Scientific Officer Fred Ramsdell who, like Bluestone, joined Sonoma from the Parker Institute, and Alexander Rudensky, an immunologist at the Memorial Sloan Kettering Cancer Center. Ramsdell and Rudensky are credited as co-discoverers of the FOXP3 gene that is critical to the development and function of Tregs.

Bluestone says that Sonoma continues the Treg research that he and the other co-founders had done. The company also builds on the successes and failures in cancer cell therapy research. While those therapies can treat blood cancers, its been much harder to use them to treat solid tumors. Bluestone hopes that Lyell, a South San Francisco cell therapy company, can help the company get its therapies into tissues. In addition to being a Sonoma investor, Bluestone says Lyell will be a research partner, providing access to its technology and cell therapy insights.

Sonoma also aims to go beyond autoimmune diseases. Bluestone says the companys approach could potentially address degenerative disorders, such as amyotrophic lateral sclerosis and Alzheimers disease. In the nearer term, Bluestone says the company will use the funding to better understand Tregs.

The way were approaching this field is not to be in a hurry, in a sense of feeling this pressure or need to get into the clinic with these engineered cells as quickly as possible, he says. We want to spend the time to make sure were working with the best cells possible, that we understand the science and the biology, so that it has the best chance of success.

Public domain image by Flickr user NIH Image Gallery

Frank Vinluan is an Xconomy editor based in Research Triangle Park. You can reach him at fvinluan [[at]] xconomy.com.

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Sonoma Bio Launches With $40M to Take Cell Therapy Beyond Cancer - Xconomy

QY Research recently generated a research report titled, Precision Medicine Software Market Report: Company Analysis, History and Future Overview, Global Sales Trends by 2025. The research report represents the potential growth opportunities that prevail in the global market. The report is analyzed on the basis of secondary research methodologies acquired from historic and forecast data. The global Precision Medicine Software market is expected to grow substantially and thrive in terms of volume and value during the forecast period. The report will provide an insight into the growth opportunities and restraints that construct the market. Readers can gain meaningful comprehension about the future of the market.

Competitive Landscape

The report includes numerous key players and manufacturers operating in the regional and global markets. This section demonstrates the strategies adopted by players in the Precision Medicine Software market to stay ahead in the competition. New trends and its adoption by players help readers understand the dynamics of the industry and how it can be used to their own profit. The readers can also identify the footsteps of players to understand the global market better. Company outlining of the key players such as Syapse Inc., Fabric Genomics Inc., Translational Software Inc., SOPHiA GENETICS SA, N-of-One Inc., Human Longevity Inc., Gene42 Inc., Sunquest Information Systems Inc., PierianDx Inc., LifeOmic, Foundation Medicine Inc. and 2bPrecise LLC.

Request a Sample of this report https://www.qyrconsulting.com/request-sample/7343

Global Precision Medicine Software Market: Drivers and Restraints

This section of the report includes drivers, restraints, and trends that are likely to shape the Precision Medicine Software market. The influence of drivers and restraints affect the market in each region differently. The report offers underlying drivers that compel the consumers to invest in the products and services. This section includes consumer demand and government policies that affect the Precision Medicine Software market. The detailed information assists readers in understanding the needs of consumer demands. The report provides drivers at the local and global levels to help determine the market forces. This information will help readers decide potential strategies that can help them stay ahead in the competitive industry.

Restraints provided in this section of the report contrasts the drivers segment as it explains the factors that can hamper the growth of the Precision Medicine Software market during the forecast period. Restraints play a pivotal role in the global and regional market as it bends the prospective opportunities in the market. Readers can weigh and asses the drivers and restraints before making any investments or strategies.

Global Precision Medicine Software Market: Segment Analysis

The report includes major segments such as product type and end-user that provide an array of components that determine the portfolio of the Precision Medicine Software industry. Each type furnishes information regarding the sales value during the forecast period. The application section also provides sales by volume and consumption during the forecast period. The understanding of the segment directs the readers in recognizing the importance of factors that shape the market growth.

The Market is split into Following segments which are as follows:

By Delivery Mode

Cloud-based

On-premise

By Application

Rare Diseases

Oncology

Pharmacogenomics

By End User

Healthcare Providers

Pharmaceutical and Biotechnology Companies

Global Precision Medicine Software Market: Regional Analysis

This section of the report provides detailed information about each region and how numerous factors of that particular region affect the growth of the Precision Medicine Software market. The government policies, weather, politics, and other factors determine the future of the market differently in each region.The major regions covered in the report include North America, Europe, Asia Pacific, the Middle East, and Africa, and others.

Access Full Report Details athttps://www.qyrconsulting.com/reports/precision-medicine-software-market

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Precision Medicine Software Market 2020 Growth Analysis, Share, Demand by Regions, Industry Development and Growth opportunities for Leading Players...

Embark announces preliminary research findings linking elevated levels of inbreeding to shorter lifespan in dogs; partners with breeders in commitment to improve long-term canine health

BOSTON, Feb. 10, 2020 /PRNewswire/ --Embark Veterinary, Inc., a global leader in dog genetics, today announced its partnership with the iconic Westminster Kennel Club Dog Show. This marks the second year Embark and Westminster have teamed up; the two organizations share a common goal to advance canine health research and increase the longevity and vitality of dogs.

Embark Logo (PRNewsfoto/Embark Veterinary, Inc.)

"We are excited and proud to partner with the Westminster Kennel Club Dog Show," said Ryan Boyko, co-founder and CEO of Embark. "The show's global reputation is unparalleled and gives us a chance to jointly raise awareness and increase the use of genetic health testing to positively impact the health and wellness of dogs."

Embark recently completed a preliminary research study using genetic coefficient of inbreeding (COI), that demonstrates that a higher COI is a partial predictor of shortened lifespan and decreased litter size. When looking at a single breed, the least inbred dogs can live on average a full year longer than the most inbred dogs; in some breeds this effect is even larger. The same holds true across mixed breed dogs accounting for body size and other important factors.

Responsible breeders have recently become increasingly aware of the importance of diversity in breeding healthy dogs. Before Embark, they used a dog's pedigree to help inform optimal mating pairs. However, while pedigrees provide a useful reference point, they are less accurate than robust genetic measures of inbreeding. By combining the art of breeding with the science of Embark's DNA testing, breeders can help future generations of dogs live longer, healthier lives.

"Measuring and utilizing genetic COI information empowers breeders to improve the long term health of their lines in a way that's impossible to do with pedigree data alone," said Adam Boyko, co-founder and chief science officer of Embark. "The owners and breeders involved in dog sports have long been supporters of canine health research, which makes announcing these preliminary findings at Westminster that much more empowering. We've already published several papers on genetic COI and genetic diversity in purebred dogs, and will be continuing to expand this research and build tools for breeders to support our shared goal of canine genetic health."

In addition to supporting responsible breeders, an Embark Dog DNA Test enables a mixed-breed dog owner to learn about their dog's breed ancestry, health, and more with a simple cheek swab. Through its research-grade DNA genotyping platform, Embark identifies more than 250 dog breeds in mixed-breed dogs and more than 170 genetic health conditions and traits in purebred and mixed breed dogs.

The Westminster Kennel Club Dog Show takes place from Saturday, February 8, 2020 to Monday, February 10, 2020 in New York City, NY.

About EmbarkEmbark Veterinary, Inc. launched in 2015 with a mission to end preventable disease in dogs. An Embark Dog DNA Test enables pet owners to learn about their dog's breed, ancestry, health, and what diseases may be in the future all with a simple cheek swab. By using over twice as much genetic information than any other test available, the company offers the most accurate results on the market. Embark was started by two brothers, Adam and Ryan Boyko, who have a passion for scientific research and a lifelong love of dogs. Embark is an official research partner of Cornell University College of Veterinary Medicine.

Embark is the official dog DNA test of the Westminster Kennel Club Dog Show. For further information, visit Embark's website atEmbarkvet.com, or follow Embark onFacebook,Twitter, andInstagram.

View original content to download multimedia:http://www.prnewswire.com/news-releases/embark-returns-as-the-official-canine-dna-test-of-the-westminster-kennel-club-dog-show-301001699.html

SOURCE Embark Veterinary, Inc.

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Embark returns as the official canine DNA test of the Westminster Kennel Club Dog Show - Yahoo Finance

Our friend, the telomere

Studies of the nutritional impact of milk, like those of other single foods, are all over the map, some showing benefits, other risks. Researchers have focused, of late, on the fat content of milk, thinking that the devilment is found in that particular fraction. This current study uses a unique biomarker, the length of ourtelomeres. Telomeres are the caps on the ends of our chromosomes, keeping them separate from one another. Over time, those telomeres shorten and lose their protective role. Telomeres are considered a biomarker of cellular as compared to chronological age. Truth be told, chronologic age is a significant factor in telomere shortening, but lifestyle, diet, and even the great villain oxidative stress play a role. [1]

Although much is understood about diet, oxidative stress, and cellular longevity, the role of cows milk consumption, particularly milk fat, remains unclear. To date, the relationship between milk fat intake and telomere length has rarely been studied.

The study

The researchers made use of our old friend, NHANES, or the National Health and Nutritional Examination Survey, which collected telomere lengths as part of a national sample between 1999 and 2002. That yielded roughly 7,800 DNA samples as well as information on milk and other nutritional consumption. Telomere length was measured in a scientifically objective and exacting way. Consumption of various foods was measured through self-reporting of whether participants drank milk or used it in their cereal, never, rarely (less than once a week), sometimes (once a week or more), or often (daily or more).

Additionally, they were asked about the fat content of their milk (whole, 2%, 1%, skim, nonfat). Of course, the usual covariant suspects like age, gender, ethnicity, smoking, BMI, and physical activity were also noted.

For those mathematically inclined and who like a good scare, the reduction in the base-pairs was about 69, meaning that drinking whole milk would add 4+ years to your chronologic age. So you might come away with the belief that whole milk isnt going to kill you outright, but it will age you. But wait, there is a bit more data to consider.

Fiber intake is associated with longer telomeres, as is the consumption of less dietary fats. So it is hard to implicate milk as the only nutritional factor at play here. The authors write:

Some of the dietary differences revealed among the milk fat groups were likely due to the milk composition differences that exist across the milk fat categories. However, it is possible that other dietary differences account for some of the biological aging differences among the milk fat categories. .

Apparently, if total saturated fat intake is low, the amount of milk fat consumed matters little and does not relate to biological aging. However, when total saturated fat intake is high (or moderate), milk fat consumption plays a significant role in cellular aging and telomere length.

We are left with a true, true, but not necessarily related conclusion. Whole milk consumption does reduce telomere length, whether that ages you is a different conversation. But whole milk consumption is a marker of high-fat consumption overall, so to say that milk is the underlying culprit is problematic. And that, in a nutshell, is the great difficulty of nutritional studies, we eat a variety of things, and it is the interaction and aggregation of them that may play a role. There is no one superfood, and there is no one superfood villain.

[1] Oxidative stress is related to mitochondrial leakage and subsequent oxidation and is the misunderstanding underlying the prescription of specific anti-oxidants to retard aging.

Source: Milk Intake and Telomere Length in US Women and Men: The Role of Milk Fat Fraction Oxidative Medicine and Cellular Longevity DOI: 1155/2019.1564021

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Got Milk? Milk, Telomeres & Lifespan - American Council on Science and Health

The latest iteration of Gwyneth Paltrow's controversial lifestyle brand has landed on Netflix, and hoo boy there is a lot to unpack.

Like anyone with a penchant for evidence-based medicine, I went into the series, The Goop Lab, with a sceptical eye (but an open mind).

Goop has a reputation for making unfounded health claims, and ahead of the show's release, health professionals expressed concern that it could spread pseudoscientific information and encourage a distrust in medical experts.

While Goop is careful to start each episode with a disclaimer that the show is designed to "entertain and inform not provide medical advice", it goes on to present alternative therapies (some with very limited evidence) as a treatment for various ailments, often without much-needed context.

Each episode of the six-part series generally follows the same formula: Paltrow and Goop executive Elise Loehnen sit down with a couple of experts (genuine or otherwise), discuss a health-related intervention, and send off Goop employees (or sometimes themselves) to test said intervention.

Despite being described as a "lab", the series is fairly light on science where it does have it, it tends to exaggerate and instead relies heavily on testimonials and anecdotes.

There is, however, one episode that really gets it right. So let's start there.

Goop's record on women's health is not strong (I'm looking at you, vagina steaming), so I was naturally apprehensive going into the episode on female sexuality and pleasure.

You can imagine my surprise (and utter delight) to find 35 minutes of vulva anatomy, body positivity and frank discussions about women's sexual health and autonomy.

The success of this episode is, in large part, thanks to Betty Dodson, a 90-year-old feminist sex educator and her colleague, Carlin Ross, who run workshops that aim to empower women with knowledge about their bodies.

Dodson notes that many women feel shame or embarrassment when it comes to sex, and most of the episode is spent trying to counter this.

Sex educators Carlin Ross and Betty Dodson are a highlight of The Goop Lab.

(Netflix)

Sex educators Carlin Ross and Betty Dodson are a highlight of The Goop Lab.

We get a rare and welcome glimpse of diverse, naked female bodies of all ages, and, more radically, a montage of vulvas, to demonstrate the diversity of female genitalia.

There are discussions about how porn has created unrealistic expectations about sexuality, and how women are increasingly turning to cosmetic surgery to change the appearance of their genitals.

The episode culminates in Dodson coaching Ross to achieve an on-camera orgasm, in a way that is educational, realistic, and not fetishised.

The whole approach is unabashed, yet sensitive, and feels genuinely refreshing. It left me wishing Goop would do this all the time: promote the message that vaginas and vulvas are great just as they are.

The only down-side to the episode was discovering Paltrow didn't know the difference between a vulva and vagina. To be fair, this is not uncommon.

But for someone selling products to put inside the vagina, I'd say that's a fairly major anatomical oversight.

There are a handful of episodes in the series which attempt to explore topics of genuine scientific interest, but struggle to execute them with much credibility.

Let's take the first episode, which focuses on psychedelic medicine, as an example.

In recent years, there has been a renaissance of research into the possible therapeutic effects of drugs like MDMA and psybicilin (magic mushrooms), and there are currently studies underway in Europe, the US and Australia investigating their potential to treat depression, trauma, and anxiety at the end of life.

While psychedelic-assisted psychotherapy is a genuinely promising area of research, what drug researcher Mark Haden makes clear in the episode is that the use of psychedelics in research is "completely different" to recreational use and "at no point are [researchers] advocating that people start taking MDMA or LSD or anything else".

In 2018, Gwyneth Paltrow's wellness company was estimated to be worth $250 million.

(Netflix)

In 2018, Gwyneth Paltrow's wellness company was estimated to be worth $250 million.

But Goop ignores this advice and sends four employees to Jamaica to trip on magic mushrooms under the guidance of "psychedelic elders" anyway.

A good portion of the episode is dedicated to watching the four Goopers (technical term for Goop staff) drink mushroom tea, hallucinate at the sight of the sky, and cry to themselves.

In typical Goop fashion, we hear very positive reviews: "I feel like I went through five years of therapy in about five hours".

What we don't hear is any of the side effects or risks associated with drug taking. Or how participants in clinical trials are heavily screened, and there are some mental health disorders for which psychedelic drugs are advised against.

Similarly, in episode two, the personal experience of Goop staff is favoured over scientific analysis, when we're introduced to Wim Hof, a Dutch athlete known for his ability to withstand freezing temperatures.

In the middle of winter, Hof takes a group of Goopers out to Lake Tahoe to learn his eponymous controlled breathing and cold-therapy method, which he claims can make the human body more resilient to physical and psychological stress.

Dutch athlete Wim Hof teaches Goop employees yoga in the snow at Lake Tahoe.

(Netflix)

Dutch athlete Wim Hof teaches Goop employees yoga in the snow at Lake Tahoe.

After learning to hyperventilate, meditate, and plunge into extremely cold water, one woman with a panic disorder claims to not have panic attacks any more.

Another man, not on the Goop bootcamp, says the Wim Hof method helped cure him of his auto-immune disorder.

As noted in the episode, a small 2014 study found the combination of meditation, breathing techniques and exposure to cold resulted in a temporary anti-inflammatory immune response.

However, the episode fails to include another 2014 study which suggests Hof's ability to tolerate extreme cold may come down to his genetics and high brown-fat levels.

There's interesting science to be explored around the mind-body connection and biofeedback, but we don't get much of it here.

In the fourth episode, the Goop team sets out to explore anti-ageing regimens, and this is where we really start to veer off the scientific road, so to speak.

Elise Loehnen gets facial acupuncture in The Goop Lab.

(Netflix)

Elise Loehnen gets facial acupuncture in The Goop Lab.

In a bid to reverse their "biological ages", Paltrow, Loehnen and fellow Goop executive Wendy Lauria adopt one of three diets: vegan, pescatarian or the "fast mimicking" diet (an alternative to fasting).

At the end of the episode, we learn Paltrow, who undertook the latter for five days reduces her so-called biological age the most: by 1.7 years.

While there is legitimate research investigating the connection between fasting and longevity, and evidence that calorie restriction can improve the biomarkers of ageing in animals, there is limited evidence so far that it can influence the biology of ageing in humans.

We also see in this episode Paltrow, Loehnen and Lauria undergo various cosmetic facial procedures.

The treatments which include injecting blood into the face, acupuncture needles, and inserting metal threads through cheeks (in what is ostensibly a face lift) are described by Loehnen as "a little bit more natural".

More natural than what? It's not clear.

You know how I said that at episode four, we start to veer off the scientific road? Well, in the final two episodes of The Goop Lab, the road seems to completely disappear underneath us; we are now freefalling in the Goop universe.

Episode five, titled The Energy Experience, is centred on the idea of "energy healing".

We meet John Amaral, a chiropractor and "body worker" to the stars, who claims to influence how energy moves through the body.

John Amaral supposedly works with people's energy fields moving his hands through the air as their bodies squirm below.

(Netflix)

John Amaral supposedly works with people's energy fields moving his hands through the air as their bodies squirm below.

As Julia Belluz notes in Vox, "energy" is presented uncritically as "an amorphous catch-all cause, and treatment for, so many our ailments", from psychological distress to physical pain.

At one point, Amaral invokes quantum physics, specifically the double-slit experiment which suggests the act of observing a particle has an effect on its behaviour to effectively prove that what he's doing is real.

I was *very* sceptical about the veracity of this claim, but I called Ben Buchler, a professor of quantum physics at the Australian National University, just to be sure. His response?

"It's unequivocal crackpottery."

(For context, Professor Buchler says the double-slit experiment does raise interesting questions about the nature of reality, but that it doesn't provide any scientific basis for "energy healing".)

A better way to assess the evidence for Amaral's work would be to look at studies on reiki, which are largely inconclusive.

A randomised control trial suggests the effects of energy therapy are likely to be a placebo which, should be noted, can be very powerful.

In the final episode of The Goop Lab, we meet psychic medium Laura Lynne Jackson, who, according to Goop, "gives a powerful, unexpected reading and invites the Goop gang to open up energetically".

My energetic response to this episode was mostly laughter, but that may have been because I was not wearing Goop's "psychic vampire repellent" spray.

As Goop reminds us each episode, "you should always consult your doctor when it comes to your personal health". I'd say that's sage advice.

Read more:
The Goop Lab exaggerates science and speculates, but shines on women's health - ABC News