Newswise WINSTON-SALEM, N.C. April 25, 2022 Between 40% and 60% of patients who have an opioid use disorder (OUD) also experience chronic pain. While both of these conditions have been studied separately, very little research has been done to address the needs of patients who have both.

To fill this gap, researchers at Wake Forest University School of Medicine have been awarded a five-year, $4 million grant through the National Institutes of Health (NIH) Helping End Addiction Long-term (HEAL) Initiative.

With the grant, researchers will create an Integrative Management of Chronic Pain and OUD for Whole Recovery (IMPOWR): Coordination Center for a network of clinical research centers that includes the University of New Mexico, Yale University, Albert Einstein College of Medicine and the University of Pittsburgh.

Through the Center, the School of Medicine will coordinate and support the network in the development, evaluation and implementation of patient-centered interventions with each research center conducting two to three clinical trials.

Traditionally, treatments for these conditions have been very siloed, said Dr. Meredith C.B. Adams, principal investigator and assistant professor of anesthesiology at Wake Forest University School of Medicine. There are interventions to treat chronic pain. There are interventions for opioid use, misuse or disorder, but what about treatments for people who have both? Our objective is to find effective interventions to make sure were addressing patient pain while also avoiding an escalation of opioid use disorder.

Another key component of the project will be decreasing stigma associated with these conditions, improving health equity and diminishing health disparities through educational development.

Part of addressing this crisis is understanding patient and community needs, Adams said. Many people with co-occurring chronic pain and opioid use disorder do not seek treatment because of the stigma associated with these conditions. We hope to change that.

The NIH HEAL Initiative, which launched in 2018, was created to find scientific solutions to stem the national opioid and pain public health crises.

Link:
NIH Awards Wake Forest University School of Medicine $4 Million Grant to Study Chronic Pain and Opioid Use Disorder - Newswise

Robert N. Taylor, MD, PhD: One of the questions that has been asked is, can we use these new drugs, the new elagolix kind of drugs, and as I mentioned, I think in the future we'll be having other similar compounds become available. They're in the process of undergoing FDA [United States Food and Drug Administration] approval currently, and we would expect that there might be even more options than these 2 doses of elagolix in the not-too-distant future. Can they be used in association with other kinds of therapies? As we develop a more and more holistic approach to women with endometriosis, and pain in particular, a lot of us are trying to incorporate lifestyle changes, meditation, exercise, as well as certain kinds of more natural remedies to try to help assuage the pain associated with endometriosis. I haven't had experience doing clinical trials with some of these compounds, but I'll tell you that in my own laboratory, I've been very interested in the effects of curcumin-like medications, including some synthetic versions of curcumin that are more biologically active as adjuvants, potentially, to markers for endometriosis pain. Hence, we've been interested in this.

One of the things to be concerned about a little bit is that elagolix is metabolized in the liver, through cytochrome P3A4 enzyme systems as well as the P-glycoprotein. And some of those metabolizing enzymes can be inhibited by certain herbal remedies. St. John's wort is the classic one that actually also utilizes the CYP3A4 pathway, and so with drugs that interfere with that, we might need to be kind of particularly careful. But it is hoped that we can sort of use elagolix as part of a regimen that would include other lifestyle modifications that might actually help with endometriosis pain. There are a couple of real-life challenges in the prescription of these medications. One is that even though the pharmaceutical company has been quite good at providing coupons for discounts on the medication, the cost of the medicine out of pocket is close to $1,000 per month. Some prior authorization issues and insurance formulary issues have come up in the past few years, and I know that a few of us have been kind of frustrated by the challenges to get some of these medications approved for our patients who haven't really been able to respond to other medications. It's been difficult to get patients directly on some of these drugs without having to go through a trial of the first and second level therapies before moving on to these more potent medications.

Transcript Edited for Clarity

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Clinical Implications and Integrative Treatment Modalities With Elagolix in Endometriosis - Contemporary Obgyn

The Issue

The world had taken a deep break and was having doubts about continuing to revolve, Maya Angelou says in her 1969 memoir, I Know Why the Caged Bird Sings. What if the world has started revolving and it is you who has doubts about continuing to revolve in it?

This is a totally normal response to an extraordinary life event that to some may not seem real and to others who have lost loved ones, work, finances, friends, and even a part of themselves, it is all too real. You cannot un-feel it. How do we begin revolving again at our own comfort level? Or maybe you do not want to revolve endlessly as in pre-pandemic life because, in your mind-without having to explain or justify it-it is just too risky. What if both answers were acceptable and there was no wrong way for any one person to re-acclimate to before times?

Busy Busy Americans

Pre-pandemic, there were idiosyncratic sayings like FOMO and YOLO mirroring the pioneering American spirit of seizing the day. If you work hard enough at work, at nutrition, at health, it was essentially all in your control, including planning your day. Pre-pandemic life was filled with the illusion that we were in control of our work, relationships, and daily habits. We loved to be so busy with work, busy with friends, working out, family, etc. That ended abruptly and everyones life was literally stopped, and unfortunately for so many, literally.

Pandemic FOMO

Pandemic FOMO is a real thing that people are experiencing as the world opens again, though many are not quite ready for it to go back to the way it was-and still, countless others who may have different risk tolerance or physical ailments, who may need more time before getting back to any sense of normalcy, if at all. That is the thing about pandemic FOMO, that it is out of our control depending on all of our individual risk factors or idiosyncrasies, and life may not look at all like what it looked like back in February of 2020. There are (by choice or by not) radical changes that have shifted peoples identities, relationships with friends and families, and work that may be forever altered or lost. All of this is contributing to a collective, familial, and individual trauma in addition to the major life disruptions that have happened globally.

Trauma: The Pandemic Created a Global, Collective, and Individual Trauma

Carl Jung, Americas spiritual psychologist, was the first to discuss collective, family, and individual trauma. These all run together and are each distinct. Until we acknowledge the struggle, we cannot integrate a new way of living, being, and communicating. Although we have less control now than we thought we did over what happens to us (psychologists and doctors have always realized that we have less control over our lives than we want to accept on a conscious level), our self-agency has had to bolster itself to get through this time. It is not an easy adaptation backward. The pandemic has also emboldened a culture of rudeness and entitlement-part of the Are you in? or Are you out? paradigm that has emerged. This is low-level, crisis, animal brain thinking and functioning.

Healing From Trauma: High-Level Thinking

To heal from trauma, we must slow down and shed the fight or flight and busy busy busy all the time mentality so prevalent in American culture. All the busyness before the pandemic did not leave time or facilitate the existential dilemma many of us are dealing with as the world reopens and we may not be ready for it to do so. The pandemic also exposed many other viruses that the world is fighting, such as poverty and inequity. Like a Band-Aid being ripped off, many of us are newly aware of the gravity of ills and inequities exposed from the convergence of events in the spring/summer of 2020, and we are without healthy coping mechanisms for the new reality that pre-pandemic life is gone and we are in a new phase of integration. In general, Americans are not comfortable with thinking that they are not in control of their lives, their work, finances, etc., and integrating the new reality takes new skills of adaptation we have not seen or needed before.

Adapting and Integrating to the New World

One virus that no one discusses but goes to the heart of the issue (now that we have been forced to have the space to face existential questions of identity and self) is how people were able to take the time to reflect and ask, Am I happy being so busy? Am I comfortable with the world reopening? Why am I the only one with a mask on? Or how you may not have felt comfortable when your friends invited you to a concert and it puts a real rift in the connection. It seems that because without mindful adaptation, people are using binary models as a primitive fight or flight response-and the You are either with us or against us mentality seems present. It is not so simple at all. The pandemic has exposed our hearts to ourselves and made us rethink what is right on an individual level that may not flow with friends or family or work anymore We have to dig deep to communicate these differences in risk tolerance without disrupting those connections because there is still hope that one day we will get to a new normal.

How to Fix It? Remedies for Pandemic FOMO

Practice mindfulness. What am I feeling? Really focus on the emotion, whether it is joy or grief or sadness-do not judge it; just be with it-and slowly breathe in and out through the emotion not trying to change it or fix it. Just let it be and it will pass with deep breathing and some gentle mindfulness.

Practice radical self-acceptance. Acknowledge that we all have different motivations and reasons and accept that we all have to make, live or die by our choices; so, it is critical to honor yourself without judgment or criticism. It is okay if you are fearful and uncomfortable. There is no race or timetable to get back to the busyness of the world.

Practice radical self-care. Grounding every day by walking in grass, taking a bath with Epsom salts (widely believed in the integrative medicine field to calm the nervous system), and treating yourself as you would treat your grandparent or child if he or she were sick. Practice that kindness on yourself, especially in a world that is moving faster and more abruptly than we would want it to.

All we are is dust in the wind. Practice aligning yourself with a universal presence-could be spirituality, could be religion, or could just be nature, but find something outside of yourself that is meaningful to you and does not place you at risk if you are not comfortable with everyones different levels of risk-taking.

What Will This Psychobabble Do for Me?

Radical acceptance and radical self-care are the heart and souls way to find resilience and hope. We have to be captains and stewards of ourselves. So, as America enlivens itself again and pushes boundaries that many are not ready to face yet or ever again, we must practice accepting those feelings, whether momentary or lasting, without judgment or reprisal. That is the one thing you can control. You do you. To regain a sense of self-agency, let all else fall away. After all, we must remember that despite everything we have seen and been through, ultimately, the human spirit is resilient, and hope always springs eternal.

About the Author

Hope Phillips Umansky, PhD, Consulting Psychologist, American Culture Professor.

Dr. Hope, as she is professionally known, is an esteemed professor, keynote speaker & author. As a professor, her expertise is in American culture, Writing & Rhetoric, and Leadership. Additionally, after a near-decade as a CEO for a clinical and integrative psychology and integrative health graduate institute, Dr. Hope also now works as consulting psychologist and strategist.

Find Dr. Hope on the web:

Dr. Hopes Psycho-Edu Consulting Site [https://innovationsadvocacy.com]

Hope Health and Healing, Consulting & Integrative Psychology [https://hopehealthandhealing.org]

Dr. Hope On Point [https://www.askdrhope.com]

Available for Media Interviews:

Contact: Jo AllisonPhone: 917-207-1039Email: [emailprotected]Website: http://www.MediaAmbassadors.com [https://www.mediaambassadors.com/dr-hope-umansky]

Or, Contact:

Dr. HopeEmail: [emailprotected]Website: https://www.askdrhope.com

Media ContactCompany Name: Media AmbassadorsContact Person: Jo AllisonEmail: Send EmailCountry: United StatesWebsite: https://www.MediaAmbassadors.com

Link:
#Pandemica: Adapting and Integrating to the New World - Digital Journal

MUIHs program provides the essential wellness concepts, the role of herbal medicine supporting the clinical endpoints for cannabis, and quality assurance practices so that a graduate can provide guidance on safe and effective use of cannabis products.

LAUREL, Md. (PRWEB) April 20, 2022

National Cannabis Awareness Month brings attention to the untapped potential of the cannabis plant. Maryland University of Integrative Health (MUIH)s Post-Baccalaureate Certificate in Cannabis Science: Therapeutics, Product Design, and Quality Assurance educates students about products with an emphasis on health effects, safety, formulation, and quality assurance. Through this graduate-level academic program students will gain knowledge and skills which are not typically provided by non-credit training programs, and which are valued by employers and important for advancement in the field, including research literacy, critical thinking, and problem solving.

The program teaches the scientific basis of herbal medicine and engages students to develop innovative strategies for commercializing safe and effective products. Students develop the research literacy skills to identify and describe evidence-based clinical applications of cannabis. Unique to this program, students will explore ways to combine cannabis with other herbs to optimize health benefits and reduce risks.

The Post-Baccalaureate Certificate in Cannabis Science: Therapeutics, Product Design, and Quality Assurance program provides education in the following areas:

Whether students seek to be employed in dispensaries and retail, processing and manufacturing, or as a clinician, MUIHs program provides the essential wellness concepts, the role of herbal medicine supporting the clinical endpoints for cannabis, and quality assurance practices so that a graduate can provide guidance on safe and effective use of cannabis products, said Michael Bhodi Tims, PhD, Program Director, Herbal Product Design and Cannabis Science at MUIH. The MUIH Cannabis Program was recently featured on Fox 5 News during a Cannabis Awareness Month interview with MUIHs brand ambassador, Amy Riolo, and Dr. Bhodi Tims who talked about what the Maryland recreational cannabis market can learn from medical cannabis.

Processing and manufacturing are currently two areas where regulation, knowledge, and communication are greatly needed. MUIHs Cannabis program provides the basics for understanding how to design quality, wellness-based products combining herbal medicine and cannabis-based material while complying with reputable standards such as Good Manufacturing Practice (GMP), federal and state regulations, and third-party health and safety standards.

About MUIH

Maryland University of Integrative Health (MUIH) is a leading academic institution focused on the study and practice of integrative health and wellness and one of the few universities in the U.S. dedicated solely to such practices. Deeply rooted in a holistic philosophy, its model for integrative health and wellness is grounded in whole-person, relationship-centered, evidence-informed care.

Since 1974, MUIH has been a values-driven community educating practitioners and professionals to become future health and wellness leaders through transformative programs grounded in traditional wisdom and contemporary science. MUIH has more than 20 progressive graduate degree programs in a wide range of disciplines, offered on-campus and online.

In the on-campus Natural Care Center and community outreach settings, MUIH provides compassionate and affordable healthcare from student interns and professional practitioners, delivering clinical treatments and consultations throughout each year.

For more information about MUIH, please visit http://www.muih.edu or to schedule media interviews, presentations, or events, please contact: kmeyer@muih.edu

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Maryland University of Integrative Health (MUIH) Offers a Unique Cannabis Science Program Focused on Health, Wellness, and Herbal Medicine - PR Web

The London School of Hygiene and Tropical Medicine will team up with the All-India Institute of Ayurveda, an autonomous institution under the Ministry of Ayush, to test the effect of Ashwagandha tablets in patients dealing with Long Covid. The first such exercise, the study will be conducted by the Medicines and Healthcare products Regulatory Agency (MHRA) that regulates medicines, medical devices and blood components for transfusion in the United Kingdom.

Nearly 2,500 people with Covid-19 across the UK will be part of the study, said Dr Tanuja Nesari, Director of the Indian Institute of Ayurveda at the Global Ayush Investment and Innovations Summit in Gandhinagar.

Ashwagandha (Withania somnifera) or the Indian winter cherry is known for its energy boosting and stress relieving properties and has a proven safety profile (therapeutic and adverse effects of a substance).

Broadly defined as a complex sequel of acute Covid-19 illness, marked by fatigue, brain fog, and debilitating outcome on health and quality of life, among other symptoms, many patients have been complaining of Long Covid recently, as the pandemic recedes and returns.

Symptoms can persist for a long time after recovering from Covid and these could be fatigue, musculoskeletal pain, insomnia, restlessness and anxiety. Around 2,500 persons suffering from these symptoms after recovering from Covid in the UK will be given the Ashwagandha tablet 500 mg, twice a day, for three months. They will be monitored to check whether the herb helps in faster recovery, said Dr Nesari.

Unde the aegis of Ayush Central Council for Research in Ayurvedic Sciences (CCRAS) and CSIR (Council of Scientific and Industrial Research) we completed randomised controlled preventive drug trials of 800 high-risk subjects to show the efficacy and safety of Ashwagandha in Covid-19. While the precise cause and pathology is not known in these cases, inadequate immune recovery and immunity may be involved and ashwagandha seems to be a potential therapeutic for such patients, said Dr Arvind Chopra chief clinical coordinator, AYUSH-CSIR project.

So far ashwagandha has been promoted as a supplement and immune-modulator, and this is the first time that the MHRA has given approval for its use as a medicine. An EU GMP (European Union Good Manufacturing Practice)-certified manufacturing unit will make the tablets in India. We are the knowledge partner and will supply the Ashwagandha for the tablets, Dr Nesari added.

With an aim to develop AIIMS-like model for Ayurveda, the institute is collaborating with 39 premier organisations within the country and abroad, including the Harvard Medical School and the UK Prince Charles Foundation. And the standardisation and validation of Ayurveda drugs and treatment modalities is among the institutes top priorities.

We hope the study will commence soon, said Dr Nesari, as all formalities are complete and protocol, pre-screening, drug development and patient screening have started.

The All-India Institute of Ayurveda, New Delhi, is a tertiary care hospital under the Ministry of Ayush, with the primary mandate to create an evidence base for traditional practices which are supported by technology.

These are exciting times to generate evidence-based Ayurveda for global recognition and clinical use. Recent Covid research studies in India, including the one in collaboration with the UK centre, will eventually fuel futuristic integrative medicine, said. Dr Chopra.

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Ayush Summit: New India-UK study to focus on Ashwagandhas use in treating Long Covid - The Indian Express

In this latest episode of the special series Mind Matters: An invitation to wellbeing, the endeavour is to encourage more people to come forward and seek help when needed.

This episode will focus on the complexities of grief. Grief is a natural response to loss, the emotional suffering you feel when something or someone you love is taken away. This loss can be of any kind, the loss of a loved one, the loss of a job, the loss of a relationship, or even a subtle loss.

Grief or the pain caused by this loss can be overwhelming and can also disrupt physical health making it difficult to eat, sleep or think straight. Grief is both universal and a personal experience. Yet there is often a timeline given to grieving and this can often mean that it goes unresolved.

There is no correct way to grieve and yet because of certain pressures that society puts many leave it unacknowledged and this then becomes a cause for other mental illnesses. In an effort to understand grief better, CNBC-TV18 spoke to Dr Shyam Bhat, Psychiatrist, Integrative Medicine Specialist, and Chairperson of LiveLoveLaugh Foundation; and Urmila Kandha, a fintech specialist sharing her experience, her story of grief and also of hope.

Watch video for more

First Published:Apr 21, 2022, 07:59 PM IST

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Mind Matters: How To Deal And Cope With Grief - CNBCTV18

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Dr. Andrew K. Godwin

The Arkansas Integrative Metabolic Research Center will host a Zoom seminar at 1p.m. on Tuesday, April 26,featuring Dr. Andrew K. Godwin from the Kansas University Medical System, who will discuss liquid biopsies and extracellular vesicles in cancer detection.

Pathologic analysis of tumor tissue biopsies is the gold standard for the initial diagnosis of cancer. However, recently liquid biopsies, which analyze tumor-derived material circulating in the bloodstream and other bodily fluids, are rapidly gaining traction in the clinic. These tests offer considerable potential in oncology, which include early detection, monitoring treatment response and disease recurrence. Liquid biopsy biomarkers include circulating tumor cells, cell-free DNA and extracellular vesicles (EVs). Regarding the latter, EVs are showing great promise as circulating biomarkers. Center among EVs are nano-sized vesicles (40 to 150 nm) of endocytic origin also known as small EVs/exosomes, which are produced and released by most cell types under normal physiologic and in diseased states. sEVs carry cargo representative of their originating cell, including nucleic acids, cytokines, membrane-bound receptors and a wide assortment of other, biologically active lipids and proteins. Since sEVs/exosomes travel systemically throughout the body, efforts are underway to exploit them as potential biomarkers to detect and monitor disease states. Ways to exploit sEVs for cancer diagnostics will be discussed.

Godwin is a leader in the field of translational research and precision cancer medicine. He has dedicated his scientific career to improve the care for patients diagnosed with cancer. He is the Chancellor's Distinguished Chair in Biomedical Sciences Endowed Professor, the division director of genomic diagnostics and the director of molecular oncology at the KU Medical Center and the KU Health System, respectively. Godwin was recruited to the KU Medical Center and Cancer Center in October 2010 after 26 productive years at the Fox Chase Cancer Center in Philadelphia, and his engaged participation contributed towards NCI designation in 2012, resulted in him being named the deputy director in 2013.

He is the founding director of the Kansas Institute for Precision Medicine and has received numerous scientific and academic awards, including the 2020 Higuchi-KU Endowment Research Achievement Award in Biomedical Sciences the state higher education system's most prestigious recognition for scholarly excellence. His research program continues to focus on various aspects of both basic and translational research, with an emphasis on early detection of cancer, predictive and prognostic biomarkers, liquid biopsies based on extracellular vesicles, molecular therapeutics, companion diagnostics, clinical trials, cellular therapeutics, cancer immune microenvironment and biosample ascertainment.

If you have any questions about this event, please contact Kimberley Fuller at fullerk@uark.edu.

This event is supported by the NIGMS of the National Institutes of Health under Award Number P20GM139768. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

Continued here:
AIMRC Seminar Will Discuss Biomarkers for Early Cancer Detection and Disease Monitoring - University of Arkansas Newswire

A lot has happened since 2018 when published results of the first clinically relevant peer-reviewed study showed safety and efficacy of cannabidiol (CBD) in reducing pain in dogs with osteoarthritis.1

Despite being used for thousands of years in both humans and animals, cannabinoidsthe therapeutic molecules found in Cannabis sativa Linnaeushave been stigmatized or considered an illegitimate or illegal therapeutic tool for veterinary patients since the 1930s. This largely stemmed from legal prohibition at the federal level, which still exists today.2 There is much to be done to educate clinicians about the therapeutic indications for cannabinoids, as well as dosing ranges and harm reduction.

For clinical application, data from preclinical studies and veterinary specific clinical trials show the legitimacy and usefulness of these compounds in veterinary populations. This is especially true when comparing cannabinoid use with other novel or integrative techniques already well adopted by veterinary practitioners despite limited or conflicting evidence. However, the data on how these compounds work still need further research and dissemination to practitioners, in addition to larger powered studies and diversity in clinical use.

RESEARCH UPDATES

Although there is no FDA-approved veterinary CBD product currently available, at least 10 pharmacokinetic (PK) studies on CBD in dogs have been published, in addition to 3 safety studies evaluating clinical presentation of CBD-dominant products at various doses.1,3-12 For cats, there are 2 PK studies and 2 safety studies at variousdoses.12,13

In addition, there have been 2 published PK studies on horses, and 1 PK study on dairy calves, and multiple PK studies are underway on various species.14-19 It should be noted, given the vastly different formulations and ratios of various cannabinoids (there are more than 120 described so far), that it cannot be assumed all products will have the same bioavailability or efficacy when compared with those used in the published studies. Despite alkaline phosphatase elevations in a small percentage of dogs and a transient alanine aminotransferase elevation in 1 cat in 1 of the studies, the therapeutic index appears to be very high, meaning these products are safe when properly manufactured and tested.

Studies on pain management with cannabinoids such as CBD have not addressed effectiveness on acute pain, although anecdotes suggest effectiveness. However, 5peer-reviewed studies show moderate to good efficacy in decreasing pain scores in dogs with chronic pain from osteoarthritis.1,20-23 Another possible use of cannabinoids is for epilepsy. One published study showed an approximate 33% decrease in seizure frequency and severity with the addition of what is considered a low dose of aCBD-dominant product for dogs with intractable idiopathic epilepsy when comparing dosing of CBD for epilepsy in people.24 A longer-term study using a higher dose isunderway.

Results of a randomized PK study showed that administering phenobarbital with a CBD product led to no major concerns for drug-to-drug interaction.25 In addition, anxiety and behavior modification warrant better-designed clinical studies. Two published studies show some or no change in the temperament of shelter dogs given CBD when exposed to loud auditory triggers and animal caretakers.26,27 Other studies are investigating CBD use for conditions such as atopic dermatitis in dogs, stomatitis in cats, epilepsy in dogs, quality of life in canine patients with cancer, acute pain in dogs, and anxiety in cats.

LEGISLATIVE UPDATES

Products derived from hempdefined as any cannabis plant with less than 0.3% -9-tetrahydrocannabinol (THC)remain legal at the federal level, whereas the legality of products derived from marijuana (defined as any cannabis plant with more than 0.3% THC) varies from state to state. Even in states where all forms and uses of cannabis have been decriminalized, guidance from state boards of veterinary medicine ranges from no guidance to legislation and regulations around veterinarians ability to recommend or even discuss the use of cannabis in their patients. In Nebraska and Idaho, any cannabis-derived product is illegal, regardless of whether it comes from marijuana or hemp.

The authors reached out to 48states veterinary medicine boards and received responses from 19 (Table28-33). The authors believe that products derived from hemp belong in the same category as other nutraceuticals or supplements that veterinarians recommend every day, often with less scientific backing and data than what exists for cannabinoid-containing products. To that end, CBD has a monograph in Plumbs Veterinary Drug Handbook.34

EMERGING PRODUCT TRENDS

Cannabigerol (CBG)

Research on this cannabinoid is limited but growing.35 CBG is a precursor molecule for many of the cannabinoids produced by the cannabis plant, including both CBD and TCH. It is noninebriating and demonstrates effects on the neurological system, making it a potential therapeutic in epilepsy and other neurological conditions. Human studies are underway for its use in Huntington disease, Parkinson disease, irritable bowel syndrome, and inflammatory bowel disease. Ithas high affinity for both 2 and serotoninreceptors.

Cannabinol (CBN)

This cannabinoid is a product of oxidation or aging of THC and is often found in products that have been stored for long periods or those exposed to heat during storage. It binds to CB1 receptors in the endocannabinoid system, just as THC does, but is approximately 75%less potent at these receptors than THC. In historic studies, CBN has shown sedative and anticonvulsant effects, which has led to its use as a sleep aid in humans. Recent human-based research has not demonstrated clear evidence of CBN as a sleep aid, though it may work in this way as part of the entourage effect when combined with other cannabinoids and terpenes in full- and broad-spectrum products.36

Nepetalactone This terpene has been isolated as the primary active ingredient in catnip and silvervine and is 1 of the hundreds of terpenes found in cannabis. At least 1 veterinary cannabis company is looking to develop nepetalactone in feline products to harness its therapeutic effects of mild sedation andeuphoria.

-8 THC

The new kid on the block, -8 THC is a molecule that can be synthesized from CBD, including CBD that is derived from hemp. In this way, it is marketed as legal THC. It is completely unregulated and requires the heavy use of industrial solvents and other chemicals to force the conversion of CBD to -8 THC, some of which may remain in any final product. ProVerde Laboratories has tested hundreds of such products with a wide variation in cannabinoids and other molecules found, some of which have no safety data whatsoever. -8 THC is reported to be anywhere from 20% to 80% less potent than -9 THC (the naturally occurring isomer of THC found in cannabis), requiring much higher doses for similar effects. There is no veterinary indication for its use, and safety concerns, as well as lack of consistency, make it questionable for human use as well.37

For information on the legal status of all forms of cannabis in your state, visit https://www.norml.org/laws/

Liz Hughston, MEd, RVT, CVT, LVT, LMVT, VTS (SAIM) (ECC); and Stephen Cital, RVT, SRA, RLAT, CVPP, VTS-LAM, co-authored the textbook Cannabis Therapy in Veterinary Medicine: A Complete Guide, with fellow co-authors Katherine Kramer and James S. Gaynor. The book was released in 2021.

References

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Debate continues over CBD therapy - DVM 360

Leonard Perlmutter, Founder and Director of The American Meditation Institute

AVERILL PARK, N.Y. (PRWEB) April 26, 2022

To reduce burnout symptoms experienced from financial worries, inflation, the ongoing COVID pandemic, political incivility, and the Russian invasion of Ukraine, Leonard Perlmutter, Yoga Scientist and Founder of the American Meditation Institute, will teach a special six-session Foundation Course for optimizing the wisdom of the Conscience May 3 - June 6, 2022 Tuesday evenings 6:30 to 8:30pm ET on Zoom. This one-of-a-kind, time-tested program, which will offer easy-to-use tools to transform negative and poisonous emotional energy into beneficial, life-affirming assets, is open to the general public, and has been certified by the American Medical Association to provide attending medical physicians 18 CME (Continuing Medical Education) credit hours.

According to Leonard Perlmutter, Our modern American culture now faces a golden opportunity to go beyond its impoverished rigidity, superstition, blind customs and dogma to attain the spiritual and philosophical wealth necessary to solve all of lifes challenges. Today, a new reliance on our Conscience as our guide can make it possible for each of us to access and integrate intuitive wisdom, and to establish greater personal security, creativity and peace of mind. As we experiment with the profound gifts of the Conscience to determine our thoughts, words and deeds, we are destined to become both prophets and beneficiaries of our own Super Conscious Wisdom.

The Foundation Course begins with an understanding of the Four Functions of the Mind, as described in Perlmutters new book YOUR CONSCIENCE. Taught continuously since 1996, this unique and time-tested curriculum teaches individuals how to relieve stress and burnout, strengthen the bodys immune system, and experience increased security, self-confidence, optimism and peace of mind, while establishing a rewarding work-life balance. Perlmutters Foundation Course syllabus incorporates the following Mind/Body Medicine components: a systematic AMI Meditation procedure, meditation-in-action, easy-gentle exercises, the use of breath as medicine, an understanding of Ayurvedic medicine, and the practical power of prayer. Each weekly session combines the best of ancient Eastern wisdom with the practicality of modern Western medical science.

Mr. Perlmutters books, [YOUR CONSCIENCE], as well as The Heart and Science of Yoga have been endorsed by medical pioneers Dean Ornish MD, Bernie Siegel MD and Larry Dossey MD. Leonard has taught workshops on the benefits of the Conscience, mantra meditation and Yoga Science at the M.D. Anderson Cancer Center, Kaiser Permanente, numerous medical schools, The New York Times forum on Yoga, and the U.S. Military Academy at West Point Association of Graduates.

In 2008, AMI conducted a retrospective case study of participants who previously completed and practiced the material taught in Leonard Perlmutters Foundation Course. The study found that students experienced the following positive, reproducible, long-term health-promoting changes: lowered blood pressure, lowered heart rate, reduced cholesterol levels, decreased chest pain, diminished or extinguished acute and chronic pain, weight loss, increased breathing capacity, increased exercise capacity, improved quality and quantity of sleep, improved energy levels, increased creative capacity, diminishment of migraine headaches, significant reductions in stress and fear, elimination of irritable bowel syndrome, a general sense of happiness and optimism in all facets of life for every participant.

According to recent course graduate, Donald Starzinski MD,"As a Neurologist with a keen interest in Integrative Health and Wellness, I would strongly recommend the Foundation Course to both physicians and non-physicians. It was life-changing for me, both in my personal and professional life.

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About the American Meditation InstituteThe American Meditation Institute is a 501(c)3 non-profit educational organization devoted to the teaching and practice of Yoga Science, meditation and its allied disciplines as mind/body medicine. In its holistic approach to wellness, the AMI combines the healing arts of the East with the practicality of modern Western science. The American Meditation Institute offers a wide variety of classes, retreats, and teacher training programs. AMI also publishes Transformation, a quarterly journal of Yoga Science as holistic mind/body medicine. Call 518.674.8714 a mail or email subscription.

Media Contact:Robert Washington 60 Garner Road, Averill Park, NY 12018 Tel: 518.674.8714 Fax: 518.674.8714

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They look great in a pair of earrings, but chances are, you don't pay too much attention to your ears on a day-to-day basis. Yet social media influencers keeping up on the latest wellness trends have been seemingly obsessed with their ridged cartilage and lobes thanks to ear seeding, a modern take on acupressure that targets well-established acupuncture points within our ears.

In traditional Chinese medicine, the ear is considered a microsystem: A representation of the whole body. The ear looks like an upside-down baby with the lobe being the head, the interior ridge being the spine, and the internal organs along with the recessed areas, explains Tom Ingegno, a doctor of acupuncture and Chinese medicine based in Baltimore, Maryland.

Thats why, he explains, when pressure is applied to different spots of the ear in the ear seeding process, otherwise known as auriculotherapy, it can stimulate that point of the body. And when it does, it can help you in all sorts of ways by easing pain, lessening stress, easing allergies and more.

Ear seeds are, essentially, what they sound like: little seeds.

In traditional Chinese medicine, they are seeds of the Vaccaria plant, a type of seed that is roughly the size of poppy seeds. This [vaccaria plant] herb is used for its blood moving properties and also reduces swelling, relieves pain and promotes healing, says Sandra Subotich, a doctor of acupuncture and director of eastern medicine at Chicago-based Bian.

Today, ear seeds arent just seeds anymore. Some acupuncturists and stores sell some made of steel, silver, gold, crystal or magnets. Regardless of what theyre made of, the seeds are applied to different acupuncture spots of your ear using an adhesive or waterproof tape.

Once applied, you can wear the seeds all day or up to three to five days tops, if the adhesive holds.

Ear seeds are used to stimulate acupuncture points in the ear, by providing a constant stimulation, Subotich explains. Since the ear is a Microsystem of the entire body, ear seeds can be used to address a wide variety of issues.

These issues, according to Subotich, include sleep problems, stress and anxiety, depression, headaches, addiction, weight management and holistic pain management. Research on substantiated benefits associated with ear seeding is limited, but many practitioners convey these potential benefits to those interested in exploring naturopathic treatment options.

Ear seeding has enjoyed a boom in popularity during the pandemic. During these stressful times, ear seeding has included treating healthcare workers who are overworked and exhausted, explains Barbara Gosse, an acupuncturist and educator with Northwestern Health Sciences University, because they may help ease insomnia side effects, and help individuals deal with stress and anxiety.

Pressing on the seeds helps to more intensely stimulate the point and thereby stimulate the underlying nerves, Subotich says. This sends a stronger message through the neural pathways and helps to modulate the desired effect.

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In many ways, ear seeding is similar to acupuncture but it doesnt require any needles, which is an advantage to anyone thats got a bit of trypanophobia. Ear seeds are also easier to administer, which means that once you know where to put them, you can apply them yourself.

Ear seeds also only apply pressure to your ears skin, which makes it minimally invasive and now that the seeds are made of metals or even crystal, they can also be a bit of a fashion accessory because they look nice while you wear them. Ear seeds are also relatively low cost.

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According to those who practice traditional Chinese medicine, there are centuries of anecdotal evidence that it is effective for treating or at least easing the symptoms of many physical and psychological ailments. Thats why in 1957, Paul Nogier, a French physician, adopted the practice and published the ear map to help those in the west adopt the practice.

Unfortunately, though, there arent many large medical studies that have been published to back up the discussion of these benefits with direct correlation to ear seeds. Many smaller-scale studies, however, conducted independently have suggested that ear seeding may ease the pain on an individual basis.

A small 2013 study, for example, found that ear seeding could help reduce low back pain and improve mobility, while a 2015 study found the practice might increase pain tolerance. An older 2010 study shared in the Journal of Alternative Medicine also found ear seeding might relieve mild to moderate pain and a 2020 review of 14 other studies from Brazil found ear seeds could effectively reduce musco-skeletal pain. A 2021 study in the Journal of Personalized Medicine, meanwhile, found it could ease menstrual pain, causing people to need fewer pain medications.

Other studies have supported some of the other holistic health claims that ear seeding aficionados have floated in the past:

Still, says Ingegno, ear seeding works best on people who have moderate symptoms who are looking for simple relief and not expecting miracles. In addition, many people also find that it benefits them most when it is practiced alongside regular traditional acupuncture sessions.

The short answer? Yes! Ear seeds are generally considered safe to use as they are topically applied with little to no invasive materials used. There may be some application risks, however, that you should be aware of.

Some people are sensitive to the adhesive used to apply the seed (particularly if they have a latex allergy) or the metal of the seed itself, Gosse explains. This can cause some itching, discomfort or redness all signs that you should remove the ear seed right away.

Youll also want to avoid ear seeds if you have cracks, scratches or other injuries to your skin as the seeds could aggravate those injuries further.

In addition, Ingegno says, you dont want to leave them in place too long as you may develop a divot in the skin where the ear seed was placed.

Ear seeds generally stay in place pretty well but there is a small possibility they can fall off and fall into your ear canal, which could cause injury to your ear or lead to an infection. In 2015, the scientific community shared a record of what happened to a woman after the seed fell through a hole in her eardrum and had to be surgically removed.

You can buy ear seeds from an acupuncturist near you, which is recommended for ear seeding newcomers, as they often provide instruction or any of the products available online.

Consumer kits like the ones available from earseeds.com come with instructions, a chart of the relevant points and tweezers, Ingegno says.

That said, all the acupuncturists we spoke with recommended talking with a professional before trying ear seeds for the first time by yourself.

[If you] have your first treatment from a professional acupuncturist, they can help you decide which points are best for you, says Laura Erlich, acupuncturist and womens holistic health specialist with Mother Nurture Wellness in Los Angeles. They can also mark points in your ear with a skin-safe marker to make it easier for you to do at home.

Just make sure that while youre applying them, you use a mirror and tweezers to apply the seed to your ear, while consulting a diagram of the acupuncture points in your ear. Be aware that everyones ears have different shapes and that you might need to adjust placement based on the shape of your ear, Ingegno explains. Dont expect your ear to look exactly like the picture in the product's chart [and] dont stress about getting them perfect.

Given the variation in everyones ears, finding the perfect location may seem impossible so aim for close enough, he adds.

When its time to take them off, use a tweezer and tilt your head towards the ground so the seed doesnt accidentally fall into your ear canal.

You might also want to give your ears short breaks between ear therapy treatments so that the skin doesnt get aggravated over time. Some experts believe they stop being as effective when worn consistently. Ideally you want to change your seeds out every 3 days, as the body will get used to the pressure, says Subotich. I generally will leave my seeds in for no more than 5-7 days and then give my ears a break for a day or two.

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Ear Seeds: What Is Ear Seeding and How Does It Work? Experts Explain - Good Housekeeping

Alternative medicine advocate Dr. Deepak Chopra is teaming up with Verizon and CareSpan on a new platform called Chopra Integrative Medicine Center Telehealth, which was designed to bring a network of holistic medical providers into one space.

The platform specializes in prevention but says it can treat patients with all types of health conditions. Specifically, the platform examines genetic and lifestyle factors in a person's life. It takes a collaborative approach to healthcare by integrating providers and services.

"TheChopraIntegrative Medicine Telehealth Platform lives in the intersection of Allopathic, Alternative and Lifestyle medicine," Ara Suppiah, MD, leading the peak living program on the platform, said in a statement.

Patients using the platform meet with a physician for "a series of 60-minute visits"which covers everything from health history, to lifestyle factors and diet to spirituality. Clinicians may meet with other colleagues to come up with a users' personalized plan. The plan typically hits on nutrition, sleep, hormones, strength and mind-body medicine.

The telehealth service runs on Verizon's BlueJeans Telehealth and is HIPAA-ready. Meanwhile, CareSpan will provide the integrated digital care platform, which the company boasts also HIPAA and ONC compliant.

WHY IT MATTERS

Telehealth became popular during the first wave of COVID-19. Whilethe numbers have dropped slightly according to a recent McKinsey report, about 40% of survey consumers said they would continue to use telehealth going forwards, up from 11% prior to the pandemic.

Chopra is pitching this new platform as a way to integrate care while using telehealth, and incorporating holistic factors into the mix.

"Because of technology, the future of well-being is very precise, it's personalized, it's predictable, it's preventable and it is a process that requires everyone's participation," Chopra said during a Facebook live call today.

THE LARGER TREND

This isn't the first time Chopra has been involved with digital health projects. In February, Fitbit announced that Chopra would headline a collection of wellness content for Fitbit Premium members. His sessions included topics such as mindfulness, breathing and stress management.

Chopra has also teamed up with author and major digital health player Dr. Eric Topol on a study to measure the physiological effects of medication.

In 2009 he founded the Chopra Foundation, a non-profit dedicated to research around mind-body practices.

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Dr. Deepak Chopra launches telehealth platform at the intersection of modern and alternative medicine - Mobihealth News

SACRAMENTO Governor Gavin Newsom today announcedthe following appointments:

Yong Ping Chen, 58, of Camarillo, has been reappointed to the California Acupuncture Board, whereshehas served since 2020. Chen has been a Professor at Alhambra Medical University since 2020 and an Acupuncturist at Chens Chinese Medicine clinic since 2002. She was Director of the Experimental Acupuncture Teaching Department and Laboratory at Guangzhou University of Chinese Medicine from 2000 to 2002, Associate Professor and Deputy Chief Physician at Southern Medical University from 1989 to 1997 and Physician and Proctologist at Linhai Traditional Chinese Medicine Hospital from 1984 to 1986. Chen was chair ofthe California Acupuncturists United Association from 2018 to 2020. She was founding Vice President of theCalifornia Acupuncture and Traditional Medicine Association and board member of American Alliance for Professional Acupuncture Safety. Chen is a member of the Asian Pacific Islander American Public Affairs Association. She earned Doctor of Medicine and Doctor of Philosophy degrees in integrative Chinese Western medicine from Guangzhou University of Chinese Medicine and a Master of Science degree in classical Chinese medicine from Zhejiang Chinese Medical University. This position requires Senate confirmation and the compensationis$100 per diem. Chen is a Democrat.

Hyun Francisco Kim, 56, of Fremont, has been reappointed to the California Acupuncture Board, where he has served since 2018. Kim has been an Acupuncture Practitioner at Harmony Holistic Wellness Center since 2019, Clinic Director and Acupuncturist at Healtones Medical Clinic since 2014 and Adjunct Clinical Instructor at Touro University California, College of Osteopathic Medicine since 2014. He was Partner at Eastridge Medical Group from 2012 to 2013 and Owner of St. Francis Clinic from 2004 to 2012. Kim is a member of the Association of Korean Asian Medicine and Acupuncture. He earned a Master of Science degree in oriental medicine and acupuncture from South Baylo University. This position requires Senate confirmation and the compensation is $100 per diem.Kim is registered without party preference.

Amy L. Matecki, 54, of El Sobrante, has been reappointed to the California Acupuncture Board, where she has served since 2016. Matecki has been Medical Director for Complementary and Integrative Medicine at Sutter Health Alta Bates Summit Medical Center since 2008, where she was an Internal Medicine Hospitalist from 2004 to 2006. Matecki has been a Consultant for Integrative Medicine and an Internal Medicine Hospitalist at Northern California Hematology and Oncology Consultants Inc. since 2004. She was Chief of the Integrative Medicine Division at Alameda Health System from 2014 to 2019, where she was an Attending Physician from 2004 to 2019 and a Chief Resident for Internal Medicine from 2003 to 2004. She was Internal Medicine Hospitalist at Inpatient Consultants of California Inc from 2003 to 2007 and Chief Resident Clinic at the Kaiser Permanente Walnut Creek Medical Center from 2003 to 2004. Matecki is president of the International Center for Integrative Medicine. She is a member of the American Society of Clinical Oncology, Society of Chinese American Physician Entrepreneurs, National Federation of Chinese Traditional Chinese Medicine Organizations, Society for Integrative Oncology, California Medical Association and the American College of Physicians-American Society of Internal Medicine. She earned a Doctor of Medicine degree from Qingdao University Medical College and a Master of Science degree in traditional Chinese medicine from the Academy of Chinese Culture and Health Sciences. This position requires Senate confirmation and the compensation is $100 per diem. Matecki is registered without party preference.

Tian Feng, 62, of Walnut Creek, has been reappointed to the California Architects Board, where he has served since 2014. Feng has been District Architect for the San Francisco Bay Area Rapid Transit District (BART) since 2001.Feng is a fellow at the American Institute of Architects and at the Construction Specifications Institute. Feng earned a Master of Science degree in architecture from the University of Southern California. This position does not require Senate confirmation and the compensation is $100 per diem. Feng is a Democrat.

Ronald A. Jones, 59, of Oakland, has been reappointed to the California Architects Board, where he has served since 2020. Jones has been Principal at Hunt Hale Jones Architects since 1995. This position does not require Senate confirmation and the compensation is $100 per diem. Jones is a Democrat.

Mitra Kanaani, 69, of San Diego, has been appointed to the California Architects Board. Kanaani has been a Professor at NewSchool of Architecture and Design since 1992, where she has held several roles, including as Chair of the Architecture Department and the Undergraduate Program, Acting Dean and Director of Integrated Path to Architectural Licensure, IPAL Program. She has been Principal at Universal Design since 1997. Kanaani earned a Master of Science degree in urban planning from the University of Tehran, a Master of Science degree in architecture from the University of New Mexico and a Doctor of Architecture degree from the University of Hawaii. She is a fellow of the American Institute of Architects, secretary for the Association of Collegiate Schools of Architecture an international evaluator at the National Architectural Accrediting Board. Kanaani is a member of the Building Technology Educators Society, International Code Council and the American Institute of Architects. This position does not require Senate confirmation and the compensation is $100 per diem. Kanaani is registered without party preference.

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Governor Newsom Announces Appointments 7.2.21 | California Governor - Office of Governor Gavin Newsom

The committees current research expert is Dr Isaac Golden, a homeopath and national secretary of the anti-fluoridation Health Australia Party. Dr Golden has no involvement in the clinical trial and The Age and The Sydney Morning Herald are not aware of any complaints made about it.

The National Institute of Integrative Medicine, based in Hawthorn, offers treatments including intravenous vitamin therapy, hyperbaric oxygen and hyperthermia therapy, while the research department studies chronic fatigue and medical cannabis.

Associate Professor Karin Ried, the trials principal investigator and the institutes director of research, told The Age that the number of cells found is directly related to the progression, or risk, of cancer.

Its basically validated worldwide, she said. I call it a photograph of the inside. You can find out why Im feeling so sick. We know it works. Were just using it as a research trial because we dont have accreditation at this point.

According to her biography on the Institutes website, Dr Ried holds qualifications in chemistry, genetics and public health.

Professor John Rasko,who studies CTC tests as director of the Li Ka Shing Gene and Cell Therapy Initiative at the University of Sydney, said an accurate test for circulating tumour cells was a long-held dream but no such test has ever been approved for use in Australia.

It is an unvalidated assay that has not been rigorously established. This raises serious ethical questions about using an unvalidated test to give medical advice, Professor Rasko said. Any pay-to-participate clinical trial of an unproven clinical test is almost always unethical in my opinion.

Professor John Rasko studies CTC tests as director of the Li Ka Shing Gene and Cell Therapy Initiative at the University of Sydney.Credit:Wolter Peeters

C. Glenn Begley, a world leading cancer trials expert and former head of cancer research at major biotech Amgen, said: Based on what is disclosed publicly, it would appear that these investigators are using an unapproved, non-validated test ... This raises a concern that legitimate, approved treatment options might be withheld from those individuals.

New screening tests are often subjected to clinical trials to see if they work. But because it is not clear if the screening method being tested can accurately detect cancer, patients are generally not told their results, Professors Rasko and Begley said.

Professor Ried confirmed that as part of the institutes clinical trial the results of the screening tests are shared with a volunteers doctor.

If its an oncologist, a specialist, a GP, its a doctor whos going to have the conversation with the patient. We never give the patients the results directly.

Any treatment decisions were then made by the doctor, not the researchers, she said.

Professor Ried said if a volunteer who had chemotherapy scheduled had a CTC test and discovered the number of circulating tumour cells was low, it was plausible patients could discuss with their doctors delaying the scheduled treatment.

A spokeswoman for the National Health and Medical Research Council said asking patients to pay to be part of a clinical trial, and sharing the results of that trial, were not direct breaches of research ethics.

It is not within the remit of the NHMRC to investigate allegations concerning any individual clinical trial or any other research, she said.

Concerned clinicians would be advised to contact the approving human research ethics committee or relevant regulatory bodies.

The trial, which has now been running for almost seven years, has led to several publications. Comparable trials do occasionally run for that length of time.

Volunteers were advised about taking garlic and green tea if cancer markers were found.Credit:iStock

A 2017 paper from the trial notes that all patients with detected CTC were advised about integrative lifestyle changes and immune-stimulating therapies, including curcumin, green tea, garlic extract, vitamin D, grape seed, lycopene, citrus pectin, medicinal mushroom extract, black cumin seed, artemisinin, and other immune stimulating nutrients.

Professor Rasko said that advice raised serious ethical questions. None of these agents are approved for use in cancer, he said.

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In a statement, National Institute of Integrative Medicine spokesman Professor Ian Brighthope said the CTC test was a screening test, not a diagnostic test, that aims to provide a biomarker for the early detection of cancer and can be used by a patients treating doctor as part of their individual treatment plan.

We are proud to contribute to the scientific evidence base showing integrative medicine can help address complex illnesses and improve health outcomes for Australians.

The trials existence demonstrates how weak Australias clinical trial regulations are, Professor Vaux said.

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Absolutely scandalous: Experts raise concerns over unapproved cancer test used in trial - The Age

A diet higher in fatty fish helped frequent migraine sufferers reduce their monthly number of headaches and intensity of pain compared to participants on a diet higher in vegetable-based fats and oils, according to a new study. The findings by a team of researchers from the National Institute on Aging (NIA) and the National Institute on Alcohol Abuse and Alcoholism (NIAAA), parts of the National Institutes of Health (NIH); and the University of North Carolina (UNC), Chapel Hill, were published in The BMJ.

The NIH team was led by Chris Ramsden, a clinical investigator in the NIA and NIAAA intramural research programs, and a UNC adjunct faculty member. Ramsden and his team specialize in the study of lipids fatty acid compounds found in many natural oils and their role in aging, especially chronic pain and neurodegenerative conditions. The UNC team was led by Doug Mann, M.D., of the Department of Neurology, and Kim Faurot, Ph.D., of the Program on Integrative Medicine.

Migraine, a neurological disease, ranks among the most common causes of chronic pain, lost work time, and lowered quality of life. More than 4 million people worldwide have chronic migraine (at least 15 migraine days per month) and more than 90% of sufferers are unable to work or function normally during an attack, which can last anywhere from four hours to three days. Women between the ages of 18 and 44 are especially prone to migraines, and an estimated 18% of all American women are affected. Current medications for migraine usually offer only partial relief and can have negative side effects including sedation, and the possibility of dependence or addiction.

This research found intriguing evidence that dietary changes have potential for improving a very debilitating chronic pain condition such as migraine without the related downsides of often prescribed medications, said Luigi Ferrucci, M.D., Ph.D., scientific director of NIA.

This study of 182 adults with frequent migraines expanded on the teams previous work on the impact of linoleic acid and chronic pain. Linoleic acid is a polyunsaturated fatty acid commonly derived in the American diet from corn, soybean, and other similar oils, as well as some nuts and seeds. The teams previous smaller studies explored if linoleic acid inflamed migraine-related pain processing tissues and pathways in the trigeminal nerve, the largest and most complex of the bodys 12 cranial nerves. They found that a diet lower in linoleic acid and higher in levels of omega-3 fatty acids (like those found in fish and shellfish) could soothe this pain pathway inflammation.

In a 16-week dietary intervention, participants were randomly assigned to one of three healthy diet plans. Participants all received meal kits that included fish, vegetables, hummus, salads, and breakfast items. One group received meals that had high levels of fatty fish or oils from fatty fish and lowered linoleic acid. A second group received meals that had high levels of fatty fish and higher linoleic acid. The third group received meals with high linoleic acid and lower levels of fatty fish to mimic average U.S. intakes. Meal plans were designed by Beth MacIntosh, M.P.H., of UNC Healthcares Department of Nutrition and Food Services.

During the intervention period, participants monitored their number of migraine days, duration, and intensity, along with how their headaches affected their abilities to function at work, school, and in their social lives, and how often they needed to take pain medications. When the study began, participants averaged more than 16 headache days per month, more than five hours of migraine pain per headache day, and had baseline scores showing a severe impact on quality of life despite using multiple headache medications.

The diet lower in vegetable oil and higher in fatty fish produced between 30% and 40% reductions in total headache hours per day, severe headache hours per day, and overall headache days per month compared to the control group. Blood samples from this group of participants also had lower levels of pain-related lipids. Despite the reduction in headache frequency and pain, these same participants reported only minor improvements in migraine-related overall quality of life compared to other groups in the study.

Changes in diet could offer some relief for the millions of Americans who suffer from migraine pain, said Ramsden. Its further evidence that the foods we eat can influence pain pathways."

The researchers noted that these findings serve as validation that diet-based interventions increasing omega-3 fats while reducing linoleic acid sources show better promise for helping people with migraines reduce the number and impact of headache days than fish-oil based supplements, while reducing the need for pain medications. They hope to continue to expand this work to study effects of diet on other chronic pain conditions.

This study was supported by the NIH NIA and NIAAA intramural research programs; and NIH grants including 1R01AT00781301A1, T32 AT003378, DK056350, and UL1TR002489.

Reference: Ramsden, CE, et al. Dietary alteration of n-3 and n-6 fatty acids for headache reduction in adults with migraine: randomized controlled trial. BMJ 2021;374:n1448. doi: 10.1136/bmj.n1448.

About the National Institute on Aging (NIA): NIA leads the U.S. federal government effort to conduct and support research on aging and the health and well-being of older people. Learn more about age-related cognitive change and neurodegenerative diseases via NIAs Alzheimer's and related Dementias Education and Referral (ADEAR) Center website. Visit the main NIA website for information about a range of aging topics, in English and Spanish, and stay connected.

About the National Institutes of Health (NIH): NIH, the nation's medical research agency, includes 27 Institutes and Centers and is a component of the U.S. Department of Health and Human Services. NIH is the primary federal agency conducting and supporting basic, clinical, and translational medical research, and is investigating the causes, treatments, and cures for both common and rare diseases. For more information about NIH and its programs, visit http://www.nih.gov.

NIH...Turning Discovery Into Health

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Consuming a diet with more fish fats, less vegetable oils can reduce migraine headaches - National Institute on Aging

Many of our first-time patients ask us what integrative medicine means and how it will help with the treatment of their symptoms or condition.

Integrative medicine is an approach that uses the best evidence-based practices to enhance conventional care. It is distinct from alternative medicine, which generally means choosing to use healing modalities in place of conventional care, or complementary medicine, which incorporates other modalities whether or not there is scientific evidence to support their use.

Integrative medicine encompasses a broad range of therapeutic approaches to achieve optimal health and wellness for those who are ill or those who are concerned about disease prevention. It is a powerful resource for those seeking to participate actively in their healthcare. At your appointment, you have the opportunity to ask questions and discover what therapies are safe and actually helpful, so that you can make rational choices about your own healthcare. Integrative medicine evaluates and incorporates specific services that address the whole person, not just the disease.

Chronic disease, often associated with challenging symptoms, may create stress and anxiety, which in turn contributes to the difficulty in managing many of those symptoms. Our patients benefit from our multi-disciplinary approach, with practitioners providing a variety of services to enhance your conventional medical treatment.

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What is Integrative Medicine: Integrative Medicine and ...

Everyone thinks they know what an allergic reaction looks like: red, itchy eyes and a runny nose that erupts within 20 minutes of entering a house with a cat; a scratchy mouth and throat after eating raw carrots; hives after taking a medicine. Allergies can be triggered by anything from birch pollen to pet dander, peanuts to penicillin, and more than 50 million people in the U.S. suffer from seasonal, indoor/outdoor, food, skin, and drug allergies every year.

As you'll recall, an allergic reaction is an immune response in which the immune system mistakes a normally harmless antigen, such as a dust particle, as a threat and produces large numbers of IgE antibodies to combat it. When the immune system comes into contact with that antigen again, the IgE antibodies are ready and waiting to mount an attack, releasing histamines and other inflammatory molecules that can result in itchy or swollen eyes, drippy nose, asthma, rashes, and a host of other physical symptoms.

Food allergies are particularly commonit's estimated that 5.6 million children in America have them (that's about 8% or 1 in 13 kids). Eight foods are responsible for about 90% of food allergy reactions: milk, eggs, wheat, soy, tree nuts, peanuts, fish, and shellfishwith milk, eggs, and peanuts being the most common. However, just about any food can cause an allergic reaction.

And as it turns out, everyone doesn't actually know what an allergic reaction looks like. In fact, some allergies don't manifest with physical symptoms at all.

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3 Reasons Childhood Allergies May Be On The Rise, From An Integrative MD - mindbodygreen.com

Orange County Business Journal, May 24, 2021OC50 2021 The BuildersHoward Gillman, Chancellor, University of California, Irvine oversees 56-year old public university with more than 37,600 students, over 25,800 employees including medical center staff.

Chad Lefteris, CEO UCI Health oversees OCs only academic medical center and all clinical and patient-serving operations. Also heads the overall UCI health system, which includes UCI Medical Center .

Henry Samueli, Chairman, Broadcom and Susan Samueli, Samueli Foundation. Duo are among OCs biggest philanthropists, funding huge health college expansion at UCI, now under construction.

Mike Mussallem, CEO, Edwards Lifesciences Corp. A $5M gift to the University of California, Irvine from Linda and Mike Mussallem will support integrative cardiology training and research in the Susan Samueli Integrative Health Institute and initiate a UC system-wide health coaching program.[Subscription required, you can request an electronic copy of the article by sending an email tocommunications@uci.edu.]

HISTORY This Week, May 17, 2021 (Podcast)Not My FingerprintMay 20, 2004. A lawyer named Brandon Mayfield walks out of a Portland, Oregon courtroom a free man. About two weeks earlier, Mayfield was arrested by the FBI because they thought they had his fingerprint on a key piece of evidence in the investigation of a terrorist train bombing in Madrid, Spain earlier that year. But by this afternoon in May, that key evidence has completely fallen apart. Today: a case of mistaken identity. Why did the FBI arrest the wrong man? And how did this case change forensic science for good? Thank you to our guests, Professor Simon Cole from UC Irvine, Steven Wax .

KPCC, May 21, 2021 (Audio)COVID-19: Delaying Second Shot Increases Antibodies Study Shows, Some Agencies Turn Away Doses As Demand Decreases And MoreIn our continuing series looking at the latest medical research and news on COVID-19, Larry Mantle speaks with Dr. Shruti Gohil at UC Irvines School of Medicine.

CNN, May 21, 2021These companies were hybrid before the pandemic. Heres how they make it workThere are some real difficulties when some people are remote and everybody else is in person. You forget about that [remote] person, you dont know what they are doing, you dont think to talk to them because it takes extra effort, said Judith Olson, professor of informatics at the University of California Irvine. Managers need to go out of their way to communicate regularly with remote workers.

Orange Coast Magazine, May 2021UCI Jazz Small GroupsJazz pianist and composer Kei Akagi announces and conducts this end-of-year concert for UC Irvine undergraduate students in the jazz program where he teaches. Musicians will perform in small groups and as soloists, and the concert will include both livestreamed performances and prerecorded videos.May 26 via the Claire Trevor School for the Arts website.

Previously In The News

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UCI IN THE NEWS MAY 24, 2021 - UCI News

Health coaches work in all of these areas, providing patients with health-related information, navigational support, connections to community resources, and personal support. Coaches focus on helping patients to identify goals, create plans to make changes, and implement changes.

People tend to hire health coaches to help them with a broad variety of health issues, such as weight loss, stress reduction, the management of chronic conditions, improving diet and exercise, tobacco cessation, addiction, and adjusting to a life-altering health event, like a heart attack.

Theres an ever-increasing demand for health coaches, and the job outlook is bright. Previously drawing some skepticism, the health coaching market reached $6 billion in 2017, a 15 percent increase from 2014. The market is forecast to reach $7.85 billion by 2022, with 121,000 practicing coaches.

Most coaches offer two sessions per month, and the session time ranges from 45 60 minutes. New coaches that are just starting out charge around $50 $75 per session. More experienced coaches charge $100 $200 per session. There are also coaches that charge by the package ($1,200 $2,400) so there is quite a range.

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Asia Pacific Health Coaching Market Thriving Revenues by 2021-28| AFPA, Dr. Sears Wellness Institute, FMCA, ExpertRating, Duke Integrative Medicine,...

SAN FRANCISCO, Feb. 17, 2021 /PRNewswire/ --The globalcomplementary and alternative medicine marketsize is expected to reach USD 404.66 billion by 2028, according to a new report by Grand View Research, Inc. It is expected to expand at a CAGR of 22.03% from 2021 to 2028. The market has witnessed a significant expansion in its consumer base in recent years owing to the benefits and philosophies that have the potential to attract customers.

The core philosophies of alternative medicine practices and complementary therapies include high preference to natural products as compared to synthetic ones, avoiding implementation of quick-fix type therapies, ensuring sufficient duration is given for healing, the onset of any illness is attributed to body-imbalance, the body has the ability to heal itself, the whole patient has to be treated and not just a specific diseased body part, and gentle therapies have to be administered before the harsh ones.

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Read 140 page research report with ToC on "Complementary And Alternative Medicine Market Size, Share & Trends Analysis Report By Intervention (Botanicals, Mind Healing, Body Healing, External Energy, Sensory Healing), By Distribution Method, And Segment Forecasts, 2021 - 2028'' at: https://www.grandviewresearch.com/industry-analysis/complementary-alternative-medicine-market

The most commonly administered and popular complementary therapies include Alexander technique, acupuncture, herbal medicine, homeopathy, aromatherapy, reiki, naturopathy, and yoga. Profitable business expansion strategies are being adopted by not only market participants but also by medical settings to ensure effective marketing and promotion of alternative medicine therapies.

Yoga, mind, and body-oriented traditional medicines are expected to gain significant traction in the coming years. Expanding applications of yoga and mind healing across chronic ailments, such as cancer, diabetes, COVID-19, and cardiovascular diseases, are set to contribute to the growth of the mind healing intervention segment.

More than half of physicians based in office set-ups in the U.S. have recommended at least one complementary health intervention to their patients, as reported by a survey published in January 2020. Additionally, a large number of female physicians integrate alternative medicine approaches, whereas male physicians most commonly recommend osteopathic manipulation and chiropractic treatment interventions. An increase in the number of such surveys is expected to enable physicians, consumers, and medical schools to gain a better understanding of the potential differences in complementary and alternative medicine use.

Companies are initiating strategic product developments to sustain the market competition. For instance, in July 2019, Colombia Nutritional launched a new process solution having a multi-phase onboarding feature designed for the efficient online launch of the latest products. The key objective of this strategic product development was to maintain minimum order quantity (MOQ) that would further improve the quality of service provided.

Grand View Research has segmented the global complementary and alternative medicine market on the basis of intervention, distribution method, and region:

List of Key Players of Complementary And Alternative Medicine Market

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About Grand View Research

Grand View Research, U.S.-based market research and consulting company, provides syndicated as well as customized research reports and consulting services. Registered in California and headquartered in San Francisco, the company comprises over 425 analysts and consultants, adding more than 1200 market research reports to its vast database each year. These reports offer in-depth analysis on 46 industries across 25 major countries worldwide. With the help of an interactive market intelligence platform, Grand View Research helps Fortune 500 companies and renowned academic institutes understand the global and regional business environment and gauge the opportunities that lie ahead.

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Sherry JamesCorporate Sales Specialist, USAGrand View Research, Inc.Phone: 1-415-349-0058Toll Free: 1-888-202-9519Email: [emailprotected]Web: https://www.grandviewresearch.comFollow Us: LinkedIn| Twitter

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Complementary And Alternative Medicine Market Size Worth $404.66 Billion By 2028: Grand View Research, Inc. - PRNewswire

The call for a more balanced and healthy living is being answered in the pandemic with the re-emergence of traditional practices for the body, mind, and soul. One such age-old practice gaining popularity is Ayurveda indicative of ancient wisdom and knowledge that practitioners have amassed over years.

One look at social media, however, will tell you that many of todays Ayurvedic practitioners are young and well-connected with several hundreds of people through their channels. They also have an advanced educational degree in the practice and allied fields to further their case. So, what is driving this change? Indianexpress.com reached out to some practitioners to understand more about their tryst with this form of medicine, catering to an audience spread across the globe, and why Ayurveda retains an edge for them.

Before the Ayurvedic medical educational system, healers carried the rich tradition of Ayurveda on their shoulders for centuries. A traditional Ayurveda healer is one who acquires knowledge from family elders. Some of them have a thorough knowledge of principles, do strict and pure application, have no bias against the modern medical system, and have sound knowledge of rare Ayurvedic herbs, explained Dr Shyam VL, WHO member for Ayurveda Health Practices Benchmark, founder and director Back to Roots, Kerala, India.

Born to parents who insisted on living with a healthy discipline, the 47-year-old with an experience of 20 years, arrived in UAE in 2000 when Ayurveda was not a recognised system of medicine. Later in 2002, he got the first Ayurveda license in the country from the Ministry of Health in UAE. In 2017, he was awarded the Health Excellence Award for the best physician by Dubai Health Authority. I got admission into Ayurveda studies after my 12th standard in India. And then I came to the realisation that Ayurveda is not just a medical system that treats a few diseases; rather, it is the way of life and the intelligence of life and nature. I was able to connect Ayurveda with the traditional and cultural lifestyle practices of my family. Ayurveda teaches us how to live in sync and harmony with nature, Dr Shyam, who has studied eight-and-a-half years in an Ayurveda college for the BAMS (Bachelor of Ayurveda, Medicine, and Surgery) and MD (Doctor of Medicine), said.

Ayurveda has its foundations in the ancient schools of Indian philosophical teachings named Samkhya, Vaisheshika, and the school of logic Nyaya. From ancient physicians, the knowledge of traditional medicines was passed on to the disciples, and then to the common man by various writings and oral narrations. The information about Ayurveda and the healing properties of the herbs was composed in the form of poems, called shlokas, as per experts.

Calling Ayurveda a Bible in terms of sustainability, Dr Shyam explained how the treatment indentifies the root cause of the issue and then aims to cure it entirely. Ayurveda teaches about longevity, keeping the body, mind, and the world in perfect harmony. Metabolic and auto-immune diseases have become major health problems. It is so important to look back into this ancient intelligence and begin to put on its principles to protect the earth and ourselves, Dr Shyam, who has over 10,000 followers on social media, said.

Seconding him, Dr Dixa Bhavsar, an ayurvedic practitioner, who regularly shares Instagram videos on simple lifestyle tweaks that can come in handy said: Ayurveda is literally science (knowledge) of life rather than just a treatment modality unlike other systems of medicine. It inculcates the whole human life as it teaches us everything from dinacharya (daily-routine), ritucharya (seasonal-routine), ratricharya (night- rituals), and pathya- apathya (what to eat and what to avoid based on ones prakriti or nature), said the 27-year-old, who has been practising for the past four years.

Back in 2016, when Dr Dixa was about to complete her internship in Ayurveda medicine, she got diagnosed with hypothyroidism just like her mother. But she refused to take any allopathy medicines. My TSH or thyroid-stimulating hormone was 28 then (which is really high). But I followed a strict Ayurvedic regime, along with yoga, and within a month, my TSH reduced to 14. This made me believe in the healing powers of Ayurveda. Since then, Ive been following and suggesting Ayurveda, Dr Dixa, who has a social media following of more than 6,000, shared.

The first line of treatment in Ayurveda is avoiding the causative factors of diseases. With food and lifestyle changes and medicines (if needed) Ayurveda can completely cure many of the diseases, said Dr Aiswarya Santhosh from Kerala.

Dr Aparna K, BAMS, MD, PhD in Ayurveda with 12 years of clinical practice, also stands by its ability to heal, provided one takes the effort to stick to a routine. I see the youth today are somehow disconnected from their rootsstaying healthy has taken a back seat due to a highly competitive work-life schedule and stress. Many lifestyle disorders like diabetes, blood pressure, PCOD have crept in very early and many of the youth are not aware of having a routine, respecting ones biological clock, etc. Its the need of the hour to spread this ancient wisdom of living healthy, setting a routine, managing emotional and physical stressors on a daily basis, said the doctor, whose father was an Ayurvedic doctor with over 40 years of experience.

She added: Ayurveda stands for predictability and sustainability. The more we are in a routine, the more our nervous system will be at ease. And immunity will improve and susceptibility to falling sick reduces.

In the pandemic, herbs and spices became the go-to immunity boosters, suggesting Ayurveda could help improve the bodys immune system, an idea also strongly propagated by the Government of India through Ministry of AYUSH as well as Ministry of Health and Family Welfare. Practitioners, however, point out that Ayurveda, with a 5000-year-long history, needs a much broader approach and understanding beyond tips, home remedies, and solution-specific approach. Ayurveda is so much more than just home remedies or having chyawanprash, turmeric, and triphala. Ayurveda guarantees permanent treatment of disorders like thyroid, diabetes, blood pressure, for which people take medicines throughout their life, claimed Dr Dixa.

For a beginner, home remedy is a good way to introduce Ayurveda, but one must realise Ayurveda is beyond it. I am trying to focus on sharing case studies, experiences and photos of patients before and after healing. Ayurveda is all about imbibing practices of diet and lifestyle which help to live a better life. So many research studies are coming up on how things work and I am sure the future is bright, said Dr Aparna, who has over 5,000 followers on her social media channels.

While the ultimate goal for any patient is to heal whether through Ayurveda, homeopathy, naturopathy, yoga, reiki or modern medicine there is always a constant comparison with modern medicine, while being called alternative or parallel. While Dr Shyam mentioned that the world is gravitating towards integrative medicine to forgo the differences, Dr Aparna aims for co-existence with both systems of medicine being needed on a case-by-case basis. While Dr Aiswarya points out that Ayurveda holds good for old-age disorders, arthritis, gastrointestinal disorders, etc, Dr Dixa is of the opinion that its important to adapt to whichever system suits the body and helps to heal. Faith in your system of medicine is of prime importance. If you believe in it, it will give you health and happiness undoubtedly, she said.

Some Ayurvedic principles that can be incorporated are:

*Wake up early (before 7 am)*Practise 12 Surya Namaskars daily*Have light breakfast, moderate lunch, and lightest dinner*Have early dinner (best before 7 pm but never post 9 pm)*No gadgets one hour before bedtime*Practise alternate nasal breathing 11 times at bedtime daily

Dr Dixa suggested some simple everyday practices beneficial for all, based on Ayurveda:

*Kavala (Oil-Pulling)- Oil-pulling involves putting one tablespoon of oil in your mouth and swishing it for about 15- 20 minutes. It is ideally done on an empty stomach, which is best to pull out all kinds of built-up toxins from the mouth; the body but only after brushing your teeth. In Ayurvedic medicine, the mouth is considered to be a mirror for the entire body, so keeping your oral cavity healthy impacts positively on gut health and overall health of your body.*Nasya (nasal-drops)- Instilling 2 drops of warm cows ghee in nostrils daily helps in improving immunity, reduces stress, prevents and helps in managing sinusitis, migraine, and cold.*Vyayama (Exercise)- We all know how exercise makes us feel energetic physically and happy mentally. Dont spend a day without exercise.*Abhyanga (Oil-massage)- Self-massage daily can help delay ageing, strengthen muscles, and reduce dryness.*Garshana (Dry brushing while bathing)- It helps detoxify the lymphatic system which in turn refreshes your skin and mind.

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Young doctors on whats keeping them hooked to Ayurveda - The Indian Express