Lab monkeys infected with coronavirus in race to find life-saving vaccine to stop the deadly outbreak – The Sun

US scientists believe they have made a breakthrough after they injected monkeys with a form of coronavirus just to see what happens.

However, the test on the rhesus macaque monkeys may have come up with a vaccine that heavily reduced the spread of a strain of coronavirus.

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The National Institutes of Health (NIH) scientists at NIAID's Rocky Mountain Laboratories in Hamilton, Montana, jabbed the luckier groups of monkeys with experimental antiviral "wonderdrug" remdesivir after or before infecting all of them with Middle East respiratory syndrome coronavirus (MERS-CoV).

They found that after six days the vaccinated ones were fine, the treated ones were ok and the untreated ones were suffering the full-blown symptoms.

They are now hopeful that they can trial the drug with the COVID-19 (Wuhan) epidemic strain, which is part of the same family of viruses and has the same symptoms.

Remdesivir is also being trialed in China and some patients with the disease have already been trying it in a desperate bid to recover.

Things are looking promising, however, scientists still need to go through human trials to be sure that the drug works before mass production can begin.

What happened in the trial?

The work involved three groups of animals:

The scientists observed the animals for six days.

Findings

All control animals showed signs of respiratory disease.

Animals treated before infection (vaccinated) fared well: no signs of respiratory disease, significantly lower levels of virus replication in the lungs compared to control animals, and no lung damage.

Animals treated after infection fared significantly better than the control animals: disease was less severe than in control animals, their lungs had lower levels of virus than the control animals, and the damage to the lungs was less severe.

An NIH spokesman said:"Remdesivir has previously protected animals against a variety of viruses in lab experiments. The drug has been shown experimentally to effectively treat monkeys infected with Ebola and Nipah viruses.

"The scientists indicate that the promising study results support additional clinical trials of remdesivir for MERS-CoV and 2019-nCoV.

"At least two clinical trials of remdesivir for 2019-nCoV are under way in China, and other patients with 2019-nCoV infection have received the drug under a compassionate use protocol."

Coronavirus has so far killed almost 2500 people and infected around 79,000 world wide.

The Venice Carnival and Giorgio Armanis Milan fashion show were shut down today after the deadly bug killed three people in Italy and 50,000 people were quarantined.

There has been a lot of backlash against the use of monkeys in research.

The UK's RSPCA estimates thousands of monkeys, mainly macaques and marmosets, are used in research and testing.

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PeTA believes that over 106,000 primates are currently used in lab reasearch in the US.

The RSPCA said: "In the UK alone, around 3,000 monkeys are used annually.

"Much of this use is to develop and test the safety and effectiveness of potential human medicines and vaccines. Primates are also used for studying how the brain functions and in research relating to human reproduction."

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Lab monkeys infected with coronavirus in race to find life-saving vaccine to stop the deadly outbreak - The Sun

Kim Westfall on traumatic cuteness and social reproduction – Artforum

February 18, 2020 Kim Westfall on traumatic cuteness and social reproduction

The New Yorkbased artist Kim Westfalls cheeky compositions of tufted yarn contend with the banality of selfhood. Her works find humor in the insatiable human ambitions for uniqueness and authenticity, but also manifest real longing for deeper meaning and social cohesion. Her latest tapestries draw connections between human reproduction, the mechanical reproduction inherent in her medium, and ideologies of the ego that keep us stuck on repeat. Splendid Bitch opened on January 23, 2020, and runs through March 7, 2020, at White Columns in New York.

THE THING ABOUT TEXTILES IS ITS THE FREAK ZONE. I work with yarn; I cant be that self-serious because its the same material you make into sweaters and stuffed animals. Its not heroic like painting because it doesnt have the same theoretical framework and history. I never go to an art supply store. I go to Michaels in the middle of the day, and its all knitters collecting balls of yarn for their Game of Thrones fan blankets and women with carts full of faux flowers to make Sandra Lee tablescapes. There are huge signs with laughing children all over the walls. Its a very Lynchian shopping experience, but were all in it together. Its very comforting to me.

I want to make a large-scale image without being chained to a loom for six months. My works are handmade, but also mechanical. I use a tufting gun, which is similar to a sewing machine in how it punches in and out. I start off with a drawing or painting done digitally, and then I project it and edit as I tuft. The gun has different speeds, so you can really fly on it. You can never achieve a perfectly clean contour. The tufted line has a nubby, almost pixelated look. As a Korean with no inherited Korean culture, Ive always found the concept of finding yourself to be a strange and ironic pursuit. In All You Can Ever Know Is Ive Never Been to Me, I depict myself flying an anthropomorphized airplane, which looks like me, to an unknown destination. Its a cursed image about the irony and inevitable failure of my self-actualization, at least according to popular notions of Asian American subjectivity. The title is a composite of All You Can Ever Know by Nicole Chunga best-selling memoir about her adoption from Koreaand the Charlene song Ive Never Been to Me. To me, both are bad-faith examples of how to find yourself.

The pop star Kyary Pamyu Pamyu has said, I try to show cuteness in a traumatic way. I do too, but I also want to show trauma in a cute way. In Korean restaurants, you can find signs with smiling cartoon hot dogs grilling themselves and baby chicks cutting up some fresh chickenmaybe their own family! In public restrooms, there are signs with a smiling cartoon toilet inviting you to throw soiled papers into its mouth and flush them out of sight. I think about Georges Batailles limit-experience, about Julia Kristevas idea of the abject as a place where meaning collapses. For me, Korea is the place where meaning collapses. I had so many ego-shattering experiences there. When Im there, Im at once an abomination and an object of envy. I am as tragic as I am lucky.

Women are treated best by society when they are newborn children, young and hot, or pregnant. I Frankensteined them all together in the piece I call Forever Young, which depicts two bodies with reproductive organs stitched together from their waists down, pumping out innocent babies in an endless cycle. Reproduction still requires a womans organs to host a baby. Maybe this wont always be the case and in the future there will be technology beyond in vitro, surrogacy, and adoption. International adoption from Korea is viewed as humanitarian by most people, but it was also pioneering in terms of commodifying intimate relationships. It also allowed Korea to outsource social welfare so it could concentrate on strengthening its other cultural exports. I am an unreliable narrator of my own history. I feel like I am endlessly guest-starring in a bunch of bad TV shows. In one, Im a white girls assistant. In another, Im an orphan. In another, Im just another artist taking up space in Brooklyn! Im every Asian girl youve ever known! My work Flaming Wheel of Law, which shows a figure spinning manically out of control, is about the feeling of being trapped in someone elses narrative. Its a cycle that keeps going around. Making textiles is so maddeningly repetitive that language really lends itself to my concerns. Its hellish, but worth the ride.

As told to Vanessa Thill

Continued here:
Kim Westfall on traumatic cuteness and social reproduction - Artforum

EASTERN AFRICA: Locusts invasion, another impact of climatic fluctuations – AFRIK 21

East Africa has been hit by a locust invasion on an unprecedented scale for several decades. In Somalia and Ethiopia, about 70,000 hectares of agricultural land have already been destroyed. Meanwhile, in Kenya, swarms up to 60 kilometres long and 40 kilometres wide have been observed, causing significant damage to agricultural production. According to the Food and Agriculture Organization of the United Nations (FAO), locusts can eat the equivalent of the food consumed by 80 million people in a single day.

The challenge for the sub-region is to find ways to limit the multiplication of these insects. The challenge for the sub-region is to find ways to limit the multiplication of these insects because Southern Sudan and Uganda are also under threat and can be attacked overnight, says Keith Cressman, a locust invasion specialist for the Food and Agriculture Organization of the United Nations (FAO), in an interview with the newspaper Le Monde. Even more so since a very large number of larval bands have been observed and new generations of these insect pests are expected to hatch in the coming weeks.

West Africa is not threatened, but the situation is such that governments in surrounding countries are also afraid of the consequences and are trying to take measures to deal with them. In Burundi, the Minister of Agriculture and Livestock held a press conference on February 4, 2020, to present the strategic axes of his action plan to the populations.

The authorities set up an inter-ministerial monitoring committee and a commission in charge of technical monitoring. Also as part of the response, a campaign to raise awareness among the population on the collection and consumption of locusts was launched. This would reduce the number of locusts to preserve crops in case of attack.

However, these measures are unlikely to be very effective in the face of a phenomenon that experts attribute to climate change on an exceptional scale.

East Africa is one of the areas most affected by climate change. According to specialists, it is caused by an ocean-atmosphere interaction phenomenon called the Indian Ocean Dipole. The climate phenomenon is created by the difference in sea surface temperature between the eastern and western zones of the Indian Ocean. According to scientists, a dipole of such intensity has not been observed for years or even decades.

This climate disruption has created ideal conditions for insect reproduction. During periods of calm known as recessionary periods locusts are generally restricted to the semi-arid and arid deserts of Africa, the Near East and South-West Asia, which receive less than 200 mm of rain per year.

According to Richard Munang, a United Nations Environment Programme expert on climate and Africa, The last five years have been the hottest since the Industrial Revolution. Studies have linked a warmer climate to more threatening locust swarms. Wet weather also encourages locusts to multiply.He also noted that widespread and above-average rains up to 400% above normal hit the Horn of Africa from October to December 2019. These abnormal rains were caused by the Indian Ocean dipole, a phenomenon accentuated by climate change.

Kenya is plagued by locust invasion since late December 2019. The Kenyan government now fears that the threat is spreading to grazing areas. A possibility that would be devastating for pastoralists. And if the locust threat has not been contained by the start of the next planting season, around March, farmers could see their fields destroyed.

To reinforce control, the country has therefore called on private companies, such as Farmland Aviation, which specialises in fertiliser spraying. Kenya now has five aircraft that spray pesticides on locusts. Even if, as Richard Munang reminds us, the impact of these chemicals on the environment and other ecosystems essential to food security cannot be neglected. For example, bees and other insects pollinate up to 70 percent of our food. Not to mention the direct impact of pesticides on human health. If nothing is done, the number of insect pests could be multiplied by 500 by the month of June, said Friday Guleid Artan, from the Climate Prediction and Applications Centre (ICPAC), part of the Intergovernmental Authority on Development, quoted by the magazine Science et Avenir.

Ins Magoum

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EASTERN AFRICA: Locusts invasion, another impact of climatic fluctuations - AFRIK 21

How did the last Neanderthals live? – BBC News

In recognition of this, Gibraltar received Unesco world heritage status in 2016. Of particular interest are four large caves. Three of these caves have barely been explored. But one of them, Gorham's cave, is a site of yearly excavations. "They weren't just surviving," the Gibraltar museum's director of archaeology Clive Finlayson tells me of its inhabitants.

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"It was in some way Neanderthal city," he says. "This was the place with the highest concentration of Neanderthals anywhere in Europe." Its not known if this might amount to only dozens of people, or a few families, since genetic evidence also suggests that Neanderthals lived in many small subpopulations.

Their occupation in Gibraltar was first established in 1848, with the discovery of the first fully adult Neanderthal skull. Since then bones of seven other Neanderthal individuals have been found, as well as numerous artefacts they used in their daily lives, such as tools, animal remains and shells.

We can date each discovery based on where it was found. Inside Gorham's cave there are many metres of sediment layers. Each layer depicts a different point in geological time. Fossil remains discovered in these layers suggest that Gibraltars Neanderthals occupied the cave on and off for more than 100,000 years.

Neanderthals may have clung on in the region until as recently as 24 to 33,000 years ago, according to the dating of one of the layers in Gorham's cave. This puts this area as one of the last known places where Neanderthals lived.

They may have spread to the surrounding coastal areas too, but the water has risen considerably in the last 30,000 years. This means any other fossil evidence has long been submerged. "We are lucky that in Gibraltar because of its steep cliffs, the evidence has stayed in these caves," says Clive.

Clive, along with his wife Geraldine and son Stewart, has been excavating these caves for many years. All three are scientists.

While the front part of the cave is relatively open, bathed in natural sunlight with a direct view of the ocean, the back is darker and splits off into several chambers. The caves remain cool in the summer and slightly warm in the colder months a perfect place to rest tired eyes and stay safe from dangerous predators.

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How did the last Neanderthals live? - BBC News

Medically Assisted Reproduction: France grapples with who should benefit – Euronews

In France, the government's bioethics bill and its emblematic measure to widen out the availability of Medically Assisted Reproduction (MAR) to all women, including singles or those in a lesbian couple, is the subject of fierce debate.

Thousands of opponents of the bill demonstrated in Paris on January 19, in a protest organised by the right-wing conservative "Marchons, enfants" collective comprising "La Manif pour Tous which, in 2012, gathered hundreds of thousands in the streets to oppose same-sex marriage.

Parliament, whose majority is centrist, passed a first draft of the bill in October but the Senate, held by a right-wing majority, sought to impose some limits last week, rekindling the debate.

The European branch of the International Lesbian and Gay Association distinguishes between two types of MAR:

"Eighty-five per cent of French people agree with the statement that 'gays, lesbians and bisexuals should have the same rights as heterosexual," Katrin Hugendubel, director of advocacy for ILGA-Europe, told Euronews citing the latest Eurobarometer survey.

She added that when "the new bioethics law finally comes into force, France will join the majority of EU member states which already guarantee access to these insemination practices."

Eighteen EU countries already allow MAR for single women. Fewer 11 have opened it up to all couples.

Some French senators say they oppose extending MAR to single women and lesbian couples because they fear a "slide" towards surrogacy.

They also say it raises questions over parenthood with Jean-Pierre Leleux, a senator for the right-wing Les Republicains party, equating opening up MAR to "the manufacture of fatherless children" while Alain Richard, a senator from the centrist La Republique En Marche, said he feared the "artificialisation of the creation of life".

Senators, like MPs before them, rejected 'post-mortem insemination' which allows women to undergo MAR despite the death of their partners but they included an amendment whereby only infertile women would have the procedure fully reimbursed by the social security welfare system.

Hugendubel said she regretted that opponents of the PMA wanted to "once again put an end to equal access" to these procedures and did so "[they are actively advocating] to perpetuate discrimination against women. for certain people in society".

For her, "this new legislation is an important step towards guaranteeing equality for all."

The advocacy director of ILGA-Europe is particularly against organisations that, on the street or on social networks, continue to press against the opening of the PMA to lesbian couples or single women.

"While groups like the Manif pour Tous present themselves as a citizen movement that speaks for the people on the street, the truth is that it is a powerful organisation with plenty of resources to fight against the sexual, reproductive and human rights of LGBTI people," she added.

The draft has now gone back to MPs who will vote on the second reading on February 4.

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Medically Assisted Reproduction: France grapples with who should benefit - Euronews

Whales Help Explain the Evolutionary Mystery of Menopause – WIRED

There's a rare human trait that doesn't often make it into debates about what makes our species unique: menopause. Humans are among just a handful of species where females stop reproducing decades before the end of their lifespan. In evolutionary terms, menopause is intriguing: how could it be advantageous for reproductive ability to end before an individual's life is over?

One possible answer: the power of the grandma's guidance and aid to her grandchildren. A paper in PNAS reports evidence that supports this explanation, showing that killer whale grandmas who have stopped reproducing do a better job of helping their grandchildren to survive than grandmothers who are still having babies of their own.

Its Not All About the Babies

The engine of evolution is offspring. In simple terms, the more babies you have that survive, the more your genes are passed on, and the better the chance of the long-term survival of those genes.

ARS TECHNICA

This story originally appeared on Ars Technica, a trusted source for technology news, tech policy analysis, reviews, and more. Ars is owned by WIRED's parent company, Cond Nast.

But there are other ways to improve the long-term survival of your genes, and that's where evolution gets a little bit more complicated than just brute-force reproduction. If you invest in your siblings' children, or your children's children, you also improve the survival of the genes you share with them. Like every other survival problem that a species must overcomefood, safety, finding a matethe dynamics of natural selection generate different solutions to the question of how to propagate your genes.

The "grandmother hypothesis" suggests that grandmas play a crucial role in the survival of their grandchildren, which obviously gives the grandmas' own genes a boost. But that doesn't explain why humansalong with killer whales, short-finned pilot whales, belugas, and narwhalsstop reproducing with decades left to live. Wouldn't it be better to just keep having babies of your own and help your grandchildren? Possibly not: in certain species, with certain family dynamics, evolutionary models show that it's more worthwhile for grandmas to invest all their resources in their grandchildren, rather than compete with their own daughters.

There's evidence from humans to support this: the grandchildren of post-reproductive grandmas get a survival boost. But there hasn't been any direct evidence of a post-reproductive grandma benefit in other species that have menopauselike killer whales. Similarly to humans, female killer whales stop reproducing around their late 30s or early 40s but can continue to live for decades after that point. Do killer whales also give their grandkids a boost?

Grandma Has Tricks Up Her Sleeve

Like humans, killer whales live in intensely social family groups. Also like humans, young killer whales need help finding food even after they've been weaned. This means an important role for grandmothers, who can share food with their grandchildren and also impart their decades of accumulated experience and wisdom by guiding their families to historically successful feeding spots.

To test whether post-reproductive killer whale grandmas improve the survival of their offspring, a group of researchers collected data on killer whale populations off the coast of Washington state and British Columbia. They tracked the interactions between hundreds of individual whales, recording births and deaths and controlling for the all-important environmental factor of salmon abundance.

Just like humans, whales can become grandmothers while they're still having babies themselves. Because they were interested in the effects of menopause, the researchers wanted to compare the effects of grandma whales that had stopped reproducing to those that were still having their own offspring.

The results showed that grandma whales played a significant role in the survival of their grandchildren. Survival rates dropped sharply for whales that had recently lost a grandmothereven adult whales of 15 or 20 years old. And this effect was more marked when the grandmother was no longer reproducing herself. It was also more extreme when salmon abundance was lower, suggesting that the ecological knowledge of grandmother killer whales is a crucial resource for their families.

Less Competition

This result ties in well with previous evidence on menopause in killer whales, which found that menopause meant a reduction in competition for resources between grandmas and their daughters.

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Whales Help Explain the Evolutionary Mystery of Menopause - WIRED

6 Facts Men Must Know About CBD and Testosterone – The Leaf Online

https://pixabay.com/photos/cbd-cbd-kapseln-cannabidiol-4474897

Testosteronelevels in men start declining after they turn 30. That worries manybecause that is where they get their sex drive, strength, and energy.

Areyou wondering what effect taking CBD has on your testosterone levels?Lets take a look at what science says, and whether cannabis canhelp you to boost testosterone levels in your body!

Accordingto a study conducted in 2017, using marijuana might contribute to increasedtestosterone levels. Researchers who led the study revealed that menwith recent cannabis use had a higher concentration of this hormonethan those who werent consuming it.

Morethan 2,000 men participated in that study, and the results indicatedthat current cannabis users have 4.27 ng/mL of testosterone, which isthe highest of all groups. Other groups included those who used to beregular users (4.03 ng/mL) and those who never consumed products fromthe plant regularly (3.6 ng/mL).

https://pixabay.com/photos/bed-sleeping-couple-covered-cover-1822497

Asthey age, men worry about their sexual stamina and sex drive themost. However, a study published in 2017 reveals that people who use cannabis products haveimproved sexual relations.

Theresearch was population-based and revealed that there is a definiteconnection between sexual frequency and cannabis use in the UnitedStates. According to participants in the study, those who consumedcannabis had 20% more sex than those who havent consumedcannabinoids-based products.

CBDis a cannabinoid that might make you more relaxed, which can benecessary after a long and tiring day at work. It can help you get inthe mood for bedroom action and improve sexual stamina. CBD workswith the endocannabinoid system (ECS) in the human body. Thanks tothat, it can promote a positive mood and pleasure. Therefore, itcreated the requirements needed to feel more aroused, which canincrease sex drive.

Youmust stick to top-quality products to experience the potentialbenefits of cannabidiol. You can choose from a variety of CBDproducts, from premiumCBD hemp flower toCBD oil and tinctures, everything is just a click away.

We already mentioned that the use of CBD and cannabis-based products could increase testosterone levels andboost your libido. According to another study, cannabis use canaffect male fertility. And although you can find research that speaksnegatively about marijuana effect on male reproductive health, nostudy mentions that about CBD in particular.

However,exciting research was published in the Human Reproduction Journal. Scientists focusedon men who visited the Massachusetts General Hospital Centre forfertility treatment. A total of 662 men participated in the study,and they agreed that the researchers can use semen and blood samples,and answer a questionnaire related to using cannabis and otherlifestyle habits.

The first interesting discovery is that more than half of the users who participated admitted to using marijuana at some point. According to the questionnaire, 11% were using cannabis-based and searching for weed online products at that moment.

Althoughthey didnt specify which products, the results still showed thatthey had 62.7 million sperm count per millimeter, if you compare thatto those who have never tried cannabis and had a 45.7 million count,you will find that the number is significantly higher in cannabisusers.

Asfor the low sperm count, the World Health Organization explains thatit is below 15 million per millimeter. The study revealed that only5% of the users who tried cannabis were under this limit, and 12% ofnon-users were in the same group.

https://pixabay.com/illustrations/hustle-and-bustle-woman-face-arrows-1738072

Haveyou ever felt anxious before you need to speak at a corporate event?That indicates you might be dealing with social anxiety nervousness and fear when you need to talk to people. High-qualityCBD oil can help you to relax and focus on your performance.

Cannabidiolcan also help handle stress. It is a common occurrence these days you might feel stressed about your job and having too many dailytasks without getting enough hours of sleep. Unfortunately, thataffects your overall health and wellness, including testosteroneproduction.

Youcan improve testosterone levels in your body by reducing stress, andthat is where CBD comes into play. Thousands of users report thatthey consume CBD oil and other cannabidiol-based products to helpwith the stress and promote a positive mood. Make sure you get yourhigh-quality cannabis from industryleader weedsmart that offers doorstep delivery.

The human body is a complex structure, and everything is related. For example, you might have had a stressful day at work, and you dont feel like exercising. On the other hand, you are aware of finding the best dabs for sale that even short training can help to improve testosterone levels.

Ifyou choose high-quality CBD products, they can positively affect yourfocus and concentration and put you in a good mood for exercising.That should help you to get up and hit the gym, head running, orengage in your favorite physical activity.

Exerciseis essential to improve testosterone production, which is whyphysical activity is crucial for men who crossed the age of 30 orwant to boost levels of this hormone. CBD might help to boost yourmotivation and get through the training, no matter how intense it is.

Thescientific name for this is gynecomastia, and even young men that arein the 20s and 30s are facing this issue. According to CNN,those who visited plastic surgeons for their man boobs problemwere advised to stop using cannabis products.

The first thing to clarify is that human research on this issue is seriously lacking. You can find indications that animals who consumed THC might have low testosterone levels.

However,that still doesnt have anything to do with CBD. The new federallaw requires hemp and hemp-based products to have under 0.3% of THCto be considered legal. That is not a concentration high enough tocause issues with gynecomastia. As long as you choose your CBDproducts wisely, you can positively affect your testosterone levels,as well as experience other potential benefits of cannabidiol.

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6 Facts Men Must Know About CBD and Testosterone - The Leaf Online

In the Face of Female Oppression, Take Refuge in the Spotted Hyena – VICE

In August 2017, former Google software engineer James Damore wrote a ten-page manifesto claiming that the disparity between men and women working as software engineers could be explained by biology. The now-infamous document (Damore's Twitter bio reads: "Author of the pro-diversity #GoogleMemo") said that men and women biologically differ in many ways and that this is what led to their representation, or lack thereof, in tech fields.

The idea that men and womens differences are derived from biology has haunted the entire decade, in fact. You may recall, for instance, that in 2005, Lawrence Summers, the president of Harvard University, similarly announced that there weren't very many women scientists at elite universities due to "issues of intrinsic aptitude."

In May of 2013, when a Pew study found that mothers were the sole or primary source of income in four of ten American households with children, Fox Business held an all-male panel to respond. Fox News contributor Erick Erickson said that women being breadwinners went against the rules of nature.

Im so used to liberals telling conservatives that theyre anti-science, Erickson said. But liberals who defend this and say it is not a bad thing are very anti-science. When you look at biology, when you look at the natural world, the roles of a male and a female in society and in other animals, the male typically is the dominant role.

People still believe that men are somehow biologically programmed to be in charge. As Angela Saini wrote in her 2017 book, Inferior: How Science Got Women Wrong and the New Research Thats Rewriting the Story: "Summers may have dared to say it, but how many people haven't thought the same? That there might be an innate essential difference between the sexes that sets us apart?"

The unspoken assertion is that women don't biologically belong in leading and demanding fields, and that they are supposed to be in more domestic and servitudinal roles. As we enter the 2020s, its clear that refuting this idea is still necessary, even though understanding sex differences this way gets the scientific evidence so wrong.

Men and women do think there are variations in how they express themselves, their physical abilities, how they parent, and their hobbies and interests, according to a 2017 Pew survey. But when it comes to the reason for those differences, men and women point to a different cause. Most men thinklike Damorethat biology explains it, while more women attribute it to societal expectations. To explain differences between men and women in the things theyre good at in the workplace, 61 percent of men said its because of biology, compared to 35 percent of women who thought so.

Erickson doubled down on his position from the Fox panel in a follow-up blog post. Pro-science liberals seem to think basic nature and biology do not apply to Homo sapiens. Men can behave like women, women can behave like men, they can raise their kids, if they have them, in any way they see fit, and everything will turn out fine in the liberal fantasy world. Except in the real world it does not work out that way.

For a deep dive into the science of gender differences, Saini's book is excellent. For a narrower counterpoint to the notion of a biologically-mandated male-dominated society, here is a pro-science example for female-dominance: the spotted hyena. It is one of several species of animals where the females run the show, and while comparing human societies to animals is problematic (more on that later), reflecting on totally matriarchal hyenas can at least remind us that it's not a steadfast rule that males have to be #1.

Native to several countries in Sub-Saharan Africa, female spotted hyenas are the typical rulers of their societies, which is rare among mammals. They are about 10 percent larger than males, much more aggressive, and socially dominant to adult males that live alongside them; their clans can comprise up to 90 hyenas all together.

Its pretty strikingly obvious when you watch these animals interact that the females are in charge, said Eli Strauss, a behavioral ecologist who works in the lab of Kay Holekamp, a zoologist at Michigan State University who has been observing hyena behavior for nearly 30 years. You can see that males are displaced from kills, prevented from feeding, and the females will come in and take the food that the males may have killed themselves.

After reaching adulthood, males will leave their biological families to become the lowest-ranking members of a new hyena clan. The females remain, and inherit the ranks of their mothers. If youre the female daughter of the highest-ranking hyena in the clan, youll get the most to eat, be the most aggressive, and produce the most successful offspring. In these and many other respects, spotted hyenas appear to violate many of the accepted rules of mammalian biology, Holekamp wrote in 2011, in a travel diary of her research for the New York Times.

Besides increased aggression, female spotted hyenas have another fascinating feature: masculinized genitalia. Their genitals are so similar to male genitalia at first glance that people believed hyenas to be hermaphrodites for centuries.

The spotted hyena doesn't have a conventional vaginal opening. Instead, her clitoris elongates out of her body, creating a pseudo-penis (also called a pseudo-phallus) that can become fully erect and is the same length as the males penis. The females urinate, get pregnant, and give birth through their pseudo-penis. Their labia are folded over and filled with fat and connective tissue to form a structure that looks remarkably like the males scrotal sac, Holekamp wrote. Even when she was examining a hyena close up, she added: I thought I was palpating real testes.

For decades, researchers have tried to explain the female spotted hyenas masculinized traits. When searching for a hormonal explanation, scientists found that spotted hyenas did have higher concentrations of androgens, or male sex hormones, compared to other female mammals. Hyena cubs that were born to mothers with higher androgens, along with their masculinized genitalia, had higher rates of aggression.

But in experiments at the University of California Berkeley, researchers found that giving pregnant spotted hyenas anti-androgens did not prevent their offspring from having masculinized genitals. They found that the ones that received the treatment, their offspring ended up still having masculinized genitalia, although it was less extreme, Strauss said. So, the androgens werent the whole story.

Holekamps lab thinks that the masculinized genitals are partially explained by evolutionary adaptation, independent of hormonal differences. When hyenas greet each other, they do so by sniffing each others erect penises (pseudo or not), so the pseudo-phallus could have evolved to serve a social role.

It also gives female hyenas control over reproduction because mating is so logistically difficult. As such, they determine which male hyena's sperm fertilizes their eggs. While observing two spotted hyenas mating in 2011, Holekamp saw a female named Baez stand still in front of a male, named Oakland, with her hindquarters toward him and her head lowering to the ground, a signal that she wouldnt bite him. Oakland attempted to mount a few times, but would veer off at the last second as if he was simply overcome by nervousness, Holekamp wrote. Finally, he managed to put his penis into Baezs pseudo-penis, which points forward and downward, so the male must hop around behind the female while he squats behind her, thrusting blindly upward and backward.

Oakland eventually achieved [penetration] while Baez remained motionless, then he lowered his chin to her shoulders, and even groomed her back with his tongue, Holekamp noted.

The social dominance of the females, combined with their genital structure, means that sexual coercion is impossible. "If the female is not keen to mate with a particular male, then hes just plain out of luck, Holekamp wrote in her travel diary.

Researchers at Holekamps lab think there could be an adaptive influence for female hyenas' aggression too: Spotted hyenas have a powerful skull and jawtheir teeth can crush bones up to 3 inches in diameterbut they don't achieve that level of strength until sexual maturity. The competition for food among hyenas is high, so Strauss said that females had to compensate with aggression, to protect and feed their offspring for longer periods of time.

Strauss said there is recent evidence that the way hyenas form and use social alliances help maintain female dominance too. Hyenas will team up together to bully a third hyena, and prefer to buddy up with their close relatives. "New work has shown that females with many social allies can overtake other females with fewer social allies and ascend to higher positions in the social hierarchy," he said. Since the males leave their families to go to new groups, they don't have as much of this supportreinforcing the female-led clan.

Spotted hyenas arent alone as a mammalian species that break the so-called normal male-dominated society. They are joined, albeit with less extreme examples, by lemurs, bonobos, red colobus monkeys, and elephants. While it's a fact that most mammalian societies are male-dominant, the point is that nature doesnt have to follow that rule, as evidenced by the wide spectrum of behaviors that exist.

In a lot of societies, its not clear cut that its either female- or male-dominant, Strauss said. There can be females that are dominant to certain males, or more of a mixed hierarchy, where certain males and females both outrank each other depending on the individual.

Strauss said that in some primate societies, theyre finding that even when males are more aggressive, it doesnt automatically make them dominant. The females can be the glue that holds society together, supporting males in competition, and determining which males are the leaders. The female [primates] are playing a much more important role than people initially thought, he said.

Ultimately, though, applying animal behavior to humans directly is what got us into this whole mess in the first place.

Sari van Anders, a neuroscientist and professor of Psychology & Women's Studies at the University of Michigan, studies how social behaviors are related to gender, and how intimacy or sexual behavior affect hormones in humans, in a field called social endocrinology. She said in humans, everything is much more complicated because we have to take culture and social constructs into account. With those caveats, she can still find it helpful to be aware of sexual diversity in nature.

[It] helps us understand that, in animals themselves, theres no one way that their reproductive capabilities, interests, or physiologies look, van Anders said. Arguments that rely on whats 'natural' can be very problematic. Thats not to say that I think that we should make decisions about humans based on what is or isnt in other speciesbut it is important because people do make those arguments.

To consider men and womens role in human society, we need a more nuanced approach. Alice Eagly is a social scientist at Northwestern University whos been conducting psychological research about sex and gender for almost 50 years. She explains gendered behavior differences in humans using a biosocial model that takes both biology and environmental determinants into account, not just one or the other.

Her theory says that every society has a division of labor between men and women and much of our psychology follows from that, meaning that the jobs and roles men and women hold lead to how they behave and think of themselves. As to how people get into their job or role, biology can be relevant. For example, for thousands of years women were more burdened by reproductionthere was little access to safe birth control, and they shouldered most of the childcare. That limited the types of work they could do.

But those divisions can change, and it reflects in our societies. There were once sex differences in average mathematical ability that favored men, and those have gone away. Women are gaining leadership roles, even if slowly. There are still some differences in the types of careers women seek out, and the fields they're interested in, but that might be because caregivers promote sex-typical activities and interests in children and very young children form gender stereotypes as they observe women and men enacting their societys division of labor, Eagly wrote in an essay about the Google memo for The Conversation. They automatically learn about gender from what they see adults doing in the home and at work.

Though it would be nice to claim pure biology or social construction to explain our gender roles as humans, we will never be able to. Many pundits make the mistake of assuming that scientific evidence favoring sociocultural causes for the dearth of women in tech invalidates biological causes, or vice versa, Eagly wrote. These assumptions are far too simplistic because most complex human behaviors reflect some mix of nature and nurture.

For better or worse, we are not hyenas. As women, we dont unilaterally control intercourse, nor do we have totally dominant behavior over the men in our society. But what we do have is the capacity to change at paces faster than evolutionary ones, and use our large cerebral cortexes and culture to restructure the division of labor, and, along with it, stereotypes, expectations, and behavior.

Even if it were true that nature had strict gender and sex rolesand hyenas prove that it isntthats not the whole story for humans, as evidenced by the fact that gender roles have shown so much change, even in the last 50 years.

People will often invoke whats 'natural' to make arguments about what is natural for humans, van Anders said. One of the important things about sexual diversity is it helps us see that theres no one right or natural way for mammals or any species to be when it comes to reproduction, sex, or sexuality.

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In the Face of Female Oppression, Take Refuge in the Spotted Hyena - VICE

The 25 best films of 2019 – The A.V. Club

About a month ago, The A.V. Club counted down its favorite movies of the 2010s. Even at 100 selections, the list couldnt hope to capture the full scope of 10 years of cinemaas plenty were eager to inform us, we excluded tons of notable movies, dammit. Who knows how our decade rundown will age from here, but one thing does seem certain already: It will look woefully light on the great movies of 2019. Whether through a reluctance to call something a masterpiece too quickly or because they just hadnt yet seen all the pertinent triumphs, our contributors went light on films from the past few months. (Call it the opposite of recency bias.) And those absences will stick out, because just one month later, its now fully clear what a powerhouse year its been for moviesfor space odysseys and class-warfare thrillers, for romances fated and doomed, for the anxieties of aging directors becoming very aware of their age. So dont just think of the list below, reflecting the individual tastes and consensus favorites of our 13 ballot-filing critics, as a salute to what 2019 had to offer theatergoers and streamers. Also think of it as an asterisk on that 2010s retrospective, celebrating the films we knew were great then andin the case of our late-breaking #1 of the yearthe ones weve rallied around since.

From the distinction the first and final film from Hu Bo on down, a bone-deep sadness permeates every aspect of this unsparing look at quotidian life in desolate, post-industrial China. With no escape, no future, and no hope, a collection of interconnected locals fixate on the rumors theyve heard about an elephant in the nearby city of Manzhouli that peacefully sits, indifferent to the suffering of the world. The four-hour runtime, gray-beige color palette, and nonstop waves of misery warded off all but the most tenacious, and those choosing to see it through to the credits werent rewarded with any hard-won kernel of comfort. The endpoint is a reckoning with the crushing weight of everyday pain, a common goal attained here by virtue of the late directors sheer conviction. Before tragically taking his own life two years ago, Hu transmuted his own depression into a force that cannot be overcome and cannot be looked past. Like air, it simply is. [Charles Bramesco]

Gaspar Nos latest stylistic provocation assembles a set of 20 or so dancers in an abandoned school forwhat else?a deranged drug trip to hell. Like the French directors previous films, this LSD-fueled dance movie overwhelms the viewer with sheer bodily sensation, and in this case features two of the most impressive set pieces of his career: an opening number set to Cerrones Supernature, captured in a single unbroken take; and a hypnotic, Busby Berkeleystyle overhead view of a dance circle thats impossible not to imagine in 3D. As ever, Nos nihilistic tendencies are on full display: Life is a collective impossibility, reads one of the films hilariously juvenile pronouncements on birth, life, and death. But theres a kind of blissful transcendence in watching this diverse dance troupes ecstatic movements, accompanied by the directors aggressive yet elegant orchestrations of light and sensation. While the film lasts, nothing else seems to matter. [Lawrence Garcia]

Were all weve got, Brad Pitts sadsack astronaut declares at the end of his journey and the edge of space. Its an admission that would leave Fox Mulder crestfallen, but comes across like a glimmer of therapeutic hope in James Grays bluntly sentimental, visually spectacular sci-fi melodrama about a stoic spaceman crossing the solar system in search of a father who never taught him how to handle his feelings. With the world on fire, its no wonder so many major filmmakers are looking now to the stars. (See the other cosmic journey a few spots down from here.) But to Gray, the inky unknown is less escape route from earthbound concerns than a roundabout path back to them. Structured like a zero-gravity Apocalypse Now but gooey as Xenomorph guts, Ad Astra says its the mysteries of inner space rather than the outer kind that really matter. All the same, it finds fresh wonders up there, from lunar pirates to fast-food franchises gone intergalactic. [A.A. Dowd]

Over the years, Jennifer Lopez has been consistently underrated as an actor, which is part of why its satisfying to see her command the screen as the fierce den mother to a money-mad crew of exotic dancers. In the crowd-pleading Hustlers, shes the center of an ensemble whose camaraderie is so genuine, you cant help but get an empowering contact high. While many filmmakers attempt to emulate Martin Scorsese, Lorene Scafaria is one of the few to really nail the balance between moral ambiguity and charisma that makes his mobsters so compelling. And like Marty, she employs flashy editing and camerawork in service of more than just pure sensation. Under her direction, Hustlers becomes a feminist counterpoint to typically all-male mob stories, taking the misogynist language of gaslighting and slut-shaming and turning it back onto men who underestimate and objectify women. In short, those Wall Streeters had it coming. [Katie Rife]

For more than two decades, the Chinese filmmaker Jia Zhangke has chronicled the shifting mores and generational values of his home province of Shanxi with a poets sense of irony. His latest centers on a gangsters girlfriend (Zhao Tao) who takes the fall for her man (Liao Fan); emerging from prison five years later, she goes searching for him in central China, where he and his old underworld partners have established themselves as semi-legitimate businessmen. With a three-part structure of changing eras and fortunes that recalls the directors flawed but compelling Mountains May Depart, Ash Is Purest White feels in many ways like a summary of Jias career to date. But at its heart is a poignant, deceptively old-fashioned story of emotional constancy in a world that refuses to keep its promises. Jia may have made his reputation on depictions of modern ennui, but he stands now as one of his generations finest directors of sincere melodrama. [Ignatiy Vishnevetsky]

Steven Soderberghs filmography is dotted with portraits of people who are very good at what they do professionally, from Brad Pitts constantly eating con artist in the Oceans franchise to Gina Caranos thigh-smothering operative in Haywire. In High Flying Bird, Soderbergh applies that same interest to the high-powered world of the NBA, where everyone is grasping for power and paper. During a six-month lockout, agent Ray Burke (Andr Holland) plans to revolutionize how basketball is played. His vision is of organized labor, worker solidarity, and profound upheaval, and Moonlight playwright Tarell Alvin McCraney deftly moves Ray from penthouse offices to community courts as he criticizes each component of this multibillion-dollar system. They invented a game on top of a game, says Bill Dukes Coach Spencer of the capitalist structure of professional sports. How High Flying Bird dismantles that makes it one of Soderberghs most urgent films in years. [Roxana Hadadi]

In My Room sports a familiar post-apocalyptic scenario: a man wakes up to discover hes seemingly the last person on Earth, and following a period of reckless freedom, decides to make the best of it. It turns out that Armin (Hans Lw), a fuckup in his professional and personal life, needed humanitys unexplained demise to discover his own utility. Though his behavior adapts to fit his new surroundings, his personality remains defiantly static. When Armin meets another survivor (Elena Radonicich), they cautiously enter into a relationship, but eventually come up against numerous red flags, all of which would have become apparent even if they had met under less extreme circumstances. Director Ulrich Khler crafts a cosmic joke about how their relationship would play out the same way, with or without an apocalypse. Yet, like all good jokes, a kernel of discomfiting truth lies at its center: People dont ever really change; they can only adjust. [Vikram Murthi]

Jordan Peeles second film doesnt offer a hook as clean or clear as the body-snatching racial appropriation of Get Out; his story of a family (and a world) stalked by subterranean doppelgngers is knottier, weirder, and less immediately digestible. Its also an ambitious piece of horror filmmaking, and maybe even funnier in its evocations of social unease than his excellent previous film. Appropriate to Peeles expertly navigated horror-to-comedy-to-domestic-drama tonal shifts, theres a virtuosic range to the performancesespecially that of Lupita Nyongo, playing predator and prey, sometimes within the same seamless split-diopter shot. Peele, working with the talented cinematographer Mike Gioulakis (who also shot another movie on this list, as well as M. Night Shyamalans Glass), has only grown as a visual artist, summoning a richly shadowed world that follows his characters around, even in broad daylight, in a kind of permanent haunting. Us also makes a perfect class-vengeance-from-below double feature with #3 on this very list. [Jesse Hassenger]

Last year, Sorry To Bother You and Blindspotting examined Bay Area gentrification with contrasting absurdity and sincerity. This year, Joe Talbot and Jimmie Fails combined those approaches in the raw, lyrical The Last Black Man In San Francisco. Playing a version of himself, Fails wanders the Black neighborhood of Bayview-Hunters Point with best friend Mont (a fantastic Jonathan Majors), observing all the changes to their community. Regularly, they travel to the home in which Fails once lived, a gorgeous Victorian that Jimmie swears his grandfather built. His clinging to the story and Monts struggle to understand his role as a playwright both serve as responses to San Franciscos transformation into a nouveau riche enclave ignorant of its own history. The Last Black Man In San Franciscos multifaceted questions about belonging are answered by a staggeringly tragic conclusion that argues, bleakly but believably, that no amount of culture can rival capital. [Roxana Hadadi]

A young woman is abandoned by her lover, only to fall for a man who looks just like him some years later, triggering a series of emotional dilemmas pestered by the memory of her first romance. Thats the basic premise of Asako I & II, which cant help but appear slight in comparison to its directors last film, the acclaimed five-hour family drama Happy Hour (2015). Yet while it comes clothed as a pop melodrama, this latest film from the Japanese writer-director Rysuke Hamaguchi brings remarkable depth to the trope of the cinematic double by probing the nature of fantasy and the slippery expectations often appended to our understanding of love and desire. Filled with warm, occasionally absurdist humor, Asako goes down easy as a high-concept romance, one equally interested in what we (fail to) value in our loved ones and our often fractured relationships with ourselves. [Beatrice Loayza]

Like the dashing, troubled Anthony (Tom Burke), The Souvenir is always hiding something. Joanna Hoggs semi-autobiographical drama manages to be many things at oncea portrait of addiction from the outside, a making-of-the-artist story, a tale of obsessive love and the ways it can make even the most sensible among us foolswithout ever feeling overstuffed, thanks in part to Helle le Fevres elliptical, elusive editing. As young filmmaker Julie, Honor Swinton Byrne remains our constant in the story that keeps ruthlessly, elegantly cutting ahead in time; her endless empathy anchors us from the moment we arrive in a new present tense. Hoggs framing, meanwhile, marries immense vulnerability with restraint; through her lens, the sight of bodies standing in a room can be almost breathtakingly beautifulwhich of course they are, in all their cruelty, fragility, and terrible life. [Allison Shoemaker]

The Farewells premise makes it sound like a farce: A large Chinese family gathers for a fake wedding banquet, as a way of saying goodbye to their dying matriarch without letting her know her diagnosis is terminal. Writer-director Lulu Wang actually lived a real-life version of this story, and while she brings some ace comic timing to its wackier elements, her film is more of a gentle and relatable domestic portrait, shaded with an understanding of the many ways that families lie to each other. Awkwafina gives an alternately funny and heartbreaking lead performance, as a nonconformist New York artist who finds this whole scheme ridiculous and who could, at any minute, blow it all up. Wang organically develops this plot to a finale as tense and emotional as any in cinema this year. [Noel Murray]

Claire Denis meditative sci-fi drama High Life lives in the extremes of human experience. Its a film about cold stars and warm bodies, set in a claustrophobic prison hurtling across an endless vacuum. This is a vision of space travel that completely rejects the square-jawed, all-American NASA paradigm, populating its self-sustaining spacecraft en route to intergalactic oblivion with a crew of dirtbag convicts that includes Robert Pattinson, Mia Goth, and Andre Benjamin. Theyre ruled over by a mad scientist played by Juliette Binoche, whose perverse obsession with human reproduction makes her the warped creation goddess of the piece. (The Greek gods were horny, too.) High Life is Denis first movie in English, but as in many of her films, long stretches of time pass in silence. As a result, its most potent moments are visual. Theyre also provocatively sexual and strange, as Denis stares into the void and finds little to inspire hope. Not nothing, but not a lot either. [Katie Rife]

Jennifer Kent could have haunted a hundred different (Blum)houses in the aftermath of her spooky sleeper The Babadook, and gotten paid handsomely to do so. Instead, the Aussie writer-director chased her debut with a much riskier kind of horror movie: a wilderness rape-revenge thriller of such extreme violence and despair that it screened with a trigger warning at some venues. Set in the occupied Tasmania of 1825, The Nightingale starkly depicts the evils of colonialism as visited upon an Irish convict (Aisling Franciosi) and the Aboriginal tracker (Baykali Ganambarr) shes hired to guide her through the bush in pursuit of the English soldiers who destroyed her life. There are sequences almost too brutal to watch, but this harrowing plunge into a dark historical chapter never slips into grindhouse gratuitousness. Those who stick with it are rewarded with a powerfully moving vision of solidarity among survivorsa film that resonates, like most of the great Westerns, with the present world. No paranormal activity could be so haunting. [A.A. Dowd]

Christian Petzolds adaptation of a 1944 Anna Seghers novel collapses the past and the present into a liminal temporal space. The plot and dialogue evokes WWIIoccupied France, talks of camps and cleansing, refugees anxiously waiting for safe passagebut Petzold uses a modern setting, eschewing period signifiers entirely. This choice engenders a hazy sense of cognitive dissonance that perfectly meshes with his characters anxious, transitional state. Georg (Franz Rogowski) flees from Paris to Marseilles with the manuscript and identification papers of a dead writer. When the Mexican consulate mistakes him for the man in question, Georg assumes his identity and takes his boat ticket out of the country, but ends up wrestling with the deception after he falls in love with the writers wife (Paula Beer). Although he cannibalizes Casablanca, mid-50s Hitchcock, and Kafka, Petzold paints a portrait of romance and displacement amid national unrest that feels entirely his own. In this fraught political climate, rarely has a film made such an obvious point so effectively: It is happening again. [Vikram Murthi]

When life seems difficult or incomprehensible, it can be comforting to believe that everYthing is secretly cOntrolled by some sinister cabal, and energizing to find clUes hidden everywhere in plAin sight. Thats the centRal idea of David RobErt Mitchells wonderfully Weird pseudo-noir, Under The Silver LAke, in which a bliSsfully unemployed, perpeTually lascivious, morally dubIous L.A. goofball (ANdrew Garfield, hilariously self-deprecatinG) starts inVestigating the mysterious disappearance of A new neighbor (RiLey Keough) and finds himself sUcked deeper and deeper into what Appears to be an elaBorate citywide cipher. Some folks mistook the protagonists paranoid, borderLine misogynistic viewpoint for the films, but Mitchell is unmistakably ridiculing thE prevalence of outlandish conspiracy Theories, even as he acknowledges their vIsceral appeal (and throws in nuMerous coded puzzles for fans to solve). No other 2019 movie spoke so clearly to the mess we find ourselvEs in. [Mike DAngelo]

Rian Johnsons witty and phenomenally entertaining whodunit may have been inspired by classic Agatha Christie adaptations, but its underlying story of fortune and upward mobility owes more to Charles Dickens (who had his own fondness for mystery plots). Explaining why, however, would involve spoiling some of the films crucial twists. After a famous mystery novelist dies of an apparent (but very suspicious) suicide on his 85th birthday, an anachronistic gentleman sleuth (Daniel Craig) arrives to investigate the family of the deceaseda rogues gallery of useless modern-day aristocrats that includes a trust-fund playboy, an alt-right shitposter, and a New Age lifestyle guru. Johnson, who made his name with geeky delights like Brickand Looperbefore hitting it big with Star Wars: The Last Jedi, finds ingenious solutions to the rules of the murder-mystery movie formula. But more impressively, he manages to stake out a moral position in a genre in which everyone is supposed to be a suspect. [Ignatiy Vishnevetsky]

Much will be written in the coming months (and years) of Greta Gerwigs Little Women, based on a beloved novel with several nearly-as-beloved adaptations. This new version does not diminish the earlier onesit elevates them, and its source material, by eschewing reverence in favor of treating the March sisters like living, breathing, messy, contradictory people. Gerwigs masterstroke was scrambling the storys chronology and reassembling it, a choice that allows us to see the growth and transformation of Louisa May Alcotts famous characters through a new lens, and which even grants unexpected ambiguity to a narrative that will be familiar to many viewers. Like a flat piece of paper folded upon itself and cut along the seams, the film unfurls to reveal a beautiful design; the uniformly excellent performances are the candle that sits behind it, sending lovely shadows dancing on the wall. [Allison Shoemaker]

A thread of quiet rebellion runs throughout Portrait Of A Lady On Fire. Painter Marianne (Nomie Merlant) challenges the limits placed on female artists in the 18th century, while young noblewoman Hlose (Adle Haenel) refuses to sit for a portrait thats part of an arranged marriage she doesnt want. Together, the two women push past the boundaries of social propriety with their slow-burning romance. Yet the greatest act of defiance comes from writer-director Cline Sciamma, who subtly shifts the lens on how historical stories are told, starting with the fact thatevery single character in her film is a woman. Sciamma presents lesbian love affairs, abortions, and warm friendships between women not as uncommon outliers but as ordinaryand, in many cases, intentionally erasedparts of human history. Portrait Of A Lady On Fire joins the canon of our most lushly realized period romances, all while defiantly carving out a space of its own. [Caroline Siede]

Elisabeth Moss hits such ferocious heights and depths as Becky Something, the self-destructive frontwoman of punk band Something She, that its easy to perceive Her Smell simply as a showcase for her intense performance. But that would be overlooking writer-director Alex Ross Perrys structural savviness, which extends beyond dividing the film into five discrete segments spanning roughly a decade, each one of which plays out virtually in real time. Perry also expertly calibrates just how much of Beckys sometimes poignant, oft-disturbing volatility we can take, repeatedly moving her out of the room or into a soundproof area and letting supporting characters (Agyness Deyn and Gayle Rankin as Beckys bandmates, Eric Stoltz as her manager, Dan Stevens as her ex) provide contextualizing counterpoint. Theres a certain theatricality to this approach, but it creates a truly indelible portrait of an artistand motherin turmoil. [Mike DAngelo]

Expanding the frenetic, panic-attack-inducing cinema of Good Time with novelistic ambition, the brothers Josh and Benny Safdie created a thrilling study of one mans compulsive self-destruction with this tragicomedy about a hustling Manhattan jewelry dealer (Adam Sandler, in the best performance of his career) who owes a fortune in gambling debts. Already on the brink of implosion, Sandlers Howard Ratner cant stop making bets, convinced that his financial (and personal) salvation will come by way of a grapefruit-size lump of Ethiopian black opal. Hes reckless, neurotic, self-deluding, an addict, equal parts sucker and scammerand perhaps more like us than wed care to admit. Packed with memorable supporting characters (and impressive turns from newcomers like Julia Fox, Keith Williams Richards, and NBA star Kevin Garnett, who plays himself), Uncut Gems establishes the Safdies as masters of anxious existential grit; their style of overlapping dialogue and tension feels like the unlikely fusion of Robert Altman and Abel Ferrara. [Ignatiy Vishnevetsky]

In Noah Baumbachs most complete picture to date, the stalwart indie filmmaker combines the vivid slice-of-life vignettes of Frances Ha with the unflinching self-examination of The Squid And The Whale. He also tells a rich and provocative story, about two basically decent people who suffer mightily once they turn their irreconcilable differences over to the rough justice of family court. Adam Driver and Scarlett Johanssonjoined by an all-star cast of supporting playersare at their best, bringing such nuance to their characters that the audience can see both why this couple fell in love and why they have to split. But Marriage Story is really Baumbachs show, as he takes what hes learned from Brian De Palma and The New Yorker short stories, breaking the arc of a messy divorce down to a series of riveting set pieces. [Noel Murray]

At the beginning of Bong Joon Hos Parasite, a familys cramped basement apartment fills with menacing-looking fumigation chemicals, and for a moment it seems that this might be one of the writer-directors more overtly fantastical horror shows, like The Host or Snowpiercer. Parasite is not quite that, but its genius lies in the way it zigzags around some genres and zips straight through others; this is a con-artist movie and a farce, a family drama, and, yes, a horror movie of sorts, even if its not a creature feature. Despite the movies eclecticism, Bongs hairpin turns are executed with sleek precision, never dropping focus from how this family will do what they can to spend some time above ground, heads above water, inside the wealthy host home where theyve insinuated themselves. Likewise, the filmmaking never loses its controlled sense of showmanship, as rhythmic and catchy as Park So-dam reciting her mantra-like cover story: Jessica, only child, Illinois, Chicago. [Jesse Hassenger]

You have to spend some time with Once Upon A Time... In Hollywood to really appreciate it. Its a film that rewards multiple viewings: Knowing the shrieking bloodbath thats to come in the explosive finale somehow takes the pressure off, allowing the viewer to put up their feet, mix a whiskey sour (or maybe a pitcher of margaritas), and just hang out with Cliff Booth (Brad Pitt) and Rick Dalton (Leonardo DiCaprio) for a couple of hours. Cliff and Rick arent quite over the hill, but theyre definitely cresting it, and the film grapples with the collision of the male ego against the brick wall of middle age with both comedy and pathos. The first is to be expected from Quentin Tarantino, whos made a career out of witty, reference-laden banter. But the second, a bittersweet wish that the good times could go on forever, reveals a wistful new side to the writer-director. Rick likes to yell about hippies, but Tarantinos hate is focused on Charles Manson (Damon Herriman) and his followers, who not only deprived the world of the sweetness and virtue of Sharon Tate (Margot Robbie) but also ended the dream of the 60s in one horrific night. Through meticulous costuming and production design, Tarantino rebuilds the Los Angeles of his childhood for Once Upon A Time, letting his vision of an unspoiled 1969 stand as a temple both to what was and what might have been. [Katie Rife]

One day, Martin Scorsese will die. Thats a difficult thing to acceptdifficult because it will be a staggering loss for film culture, but also pretty hard to even believe. Scorsese, at a very spry 77, was everywhere in 2019: igniting a debate about what is or isnt cinema; inspiring autumn hits so indebted to his style that he should have received royalties; executive-producing two of the other movies on this very list and piecing together a lost Bob Dylan concert. And yet to watch The Irishman, his gangster opus to end all gangster opuses, is to be constantly reminded of the promise of mortalityhis, ours, everyones. Make no mistake, this is a remarkably brisk three and a half hours, dramatizing half a century of organized crime through dark-comic confrontations (and an outsized Al Pacino performance) so deliriously funny, theyve already generated a whole library of memes. But right from his opening shot, a morbid parody of the Copacabana sequence in Goodfellas, Scorsese foregrounds the inevitable. And his film becomes, in its magnificently bleak final stretch, a meditation on the true consequences of the mob life, the ignoble end awaiting men like Henry Hill, Sam Rothstein, and the films own protagonist, mafia hitman Frank Sheeran (Robert De Niro, weaponizing the sleepiness of his latter-day work into a devastating portrait of moral absence). One of the many ironies of the movie is that it uses distinctly modern meansfrom de-aging technology to streaming-platform resourcesto eulogize a time-honored genre and the careers of the artists who shaped it. But however firmly Scorsese has planted himself on the vanguard, however relevant and vital and, yes, alive he remains as an artist, his latest triumph is a stark acknowledgment of whats coming. If were lucky, The Irishman says, we get to pick out our own coffin. Watching the movie, its hard to shake the feeling that Scorsese has picked his. [A.A. Dowd]

See more here:
The 25 best films of 2019 - The A.V. Club

CAMPUS: EGG DONATION – Artificial sperm cells to remove the genetic worries of sperm donation – ESHRE

A Campus meeting in November reviewed the arguments for and against donor conception, and the sometimes difficult ethical arguments raised by the prospect of a donor-conceived child. 'Artificial' sperm cells derived from testicular tissue or stem cells may resolve some of those arguments.

The problem is especially acute in cancers diagnosed in prepubertal boys in whom there are no sperm cells available for storage. Their only option for future fatherhood in the face of cancer treatment is adoption or donor sperm. And this, added Goossens, is not an exceptional problem. Incidence rates are around 17 cases per 100,000 population, with leukemia and CNS tumours the most commonly diagnosed. So the usual pathway to fertility preservation in these young cases is for the oncologist to warn of the risk to future fertility from the cancer treatments and refer to the fertility clinic. Biopsy of testicular tissue, of course, must be performed before any radio- or chemotherapy.

Goossens described two experimental techniques, spermatogonial stem cell retrieval and transplantation, and homotopic tissue grafting. The danger in the former procedure is a risk of introducing malignancy, so banked tissue must be free of malignant contamination. Experiments in mouse-to-mouse models have demonstrated spermatogenesis from tissue grafting, and most recently fully functional conception and delivery in a non-human primate (Grady). Similarly, experiments in mouse models with spermatogonial stem cell transplantation have so far proved efficient, with spontaneous pregnancy already possible.

Of course, the objective of this impressive experimental work is not merely a resolution to the question of genetic continuity in couples faced with third-party donation, but the future fertility and long-term quality of life of so many unfortunate young boys. Advances in cancer treatment have led to the increased survival of all children with cancer, and with it a new imperative for the restoration of their fertility. Not all cancer treatments cause complete testicular damage, but around one-third of children having treatment for pediatric cancers will end up infertile. Following the proof-of-concept study which saw the birth of Grady - in which testicular samples removed from prepubertal monkeys was frozen, thawed and regrafted under scrotal skin - the research group declared that their next logical step, with safety and feasibility apparent, is human trials.

1. Fayomi AP, Peters K, Sukhwani M, et al. Autologous grafting of cryopreserved prepubertal rhesus testis produces sperm and offspring. Science 2019; 363: 1314-1319.

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CAMPUS: EGG DONATION - Artificial sperm cells to remove the genetic worries of sperm donation - ESHRE

Researcher who uncovered the sex life of marsupials awarded Academy’s most prestigious medal – Australian Academy of Science

December 09, 2019

A scientist whose research has transformed our understanding of Australias iconic mammals has been recognised by the Australian Academy of Science. Professor Marilyn Renfree AO FAA has been awarded the Academys highest honour in the biological sciencesthe Macfarlane Burnet Medal and Lecture.

For half a century the committed reproductive and developmental biologist and conservationist from the University of Melbourne has been using the tammar wallaby, a small macropodid marsupial native to South and Western Australia, to study their reproduction and development.

Professor Renfree has developed contraceptive strategies for kangaroos and koalas and established marsupials as unique biomedical models for understanding human reproduction.

She is now a world authority on marsupial reproduction and development and has pioneered research on some of Australias most iconic creatures including kangaroos, koalas and now echidnas.

And with passion for her work as strong as ever, she has no plans of slowing down. Professor Renfree has just embarked on the worlds first study of the development of the embryo and newly hatched pouch young from the echidna.

Professor Renfree said hardly anything was known about marsupials when she started out.

Im passionately Australian and I really wanted to work on something Australian but when I started honours I said to my prospective supervisors: I wanted to do biochemistry and fieldwork. And they laughed at me. Well, Im still really doing biochemistry and fieldwork.

Her first paper published from her PhD in 1972 was aNaturepublication.

In her distinguished career Professor Renfree has made numerous research breakthroughs. In research with colleagues Professor Renfree conducted the first genome sequencing of an Australian marsupial, the tammar wallaby, providing new information on their evolution.

She also showed that certain genes directly control sexual development during pregnancy and even after birth in marsupials, providing a new understanding of the relative influence of genes versus hormones in sexual differentiation in all mammals. With colleagues she also discovered a new hormone pathway that explains some human disorders of sexual development.

Professor Renfree said Australia is sitting on a biological goldmine because it is home to a unique assembly of mammalsthe marsupials and monotremes.

The impact of Australias recent bushfires on Australian mammals has highlighted Australia and the worlds fascination with these special animals. We really need to put more effort, time and money into conserving and doing research on them, Professor Renfree said.

Australia has the distinction of having the worst record of mammal extinctions of any developed country and thats not a record you want to be proud of.

Professor Renfree said the Academy award is a huge honour.

Im receiving it on behalf of all of my students, PhD students and postdocs and collaborators. Without them I could have only done a fraction of what I've done, Professor Renfree said.

She was nominated for the medal by Professor James Angus FAA from the University of Melbourne.

Professor Renfree is a pioneer and forward thinker who has an ability to excite and inspire scientists from around the world by providing new insights through the study of the unique evolutionary innovations in the reproductive systems of marsupials and monotremes, Professor Angus said.

The basic science and the clinical impact of her work for humans are as important as the direct benefits of her work for Australias marsupials. Her research has undoubtedly opened the eyes of the academic world and beyond to the value of these iconic Australian mammals both for their intrinsic interest and as unique biomedical models.

Professor Renfree will receive the medal and give a lecture at the Academys Science at the Shine Dome event in May 2020. The Macfarlane Burnet Medal and Lecture honours the contributions to science by Sir MacFarlane BurnetOMKBMDFAAFRSNobel Laureate.

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Researcher who uncovered the sex life of marsupials awarded Academy's most prestigious medal - Australian Academy of Science

The Senate Just Confirmed a Trump Judge With No Real Trial or Litigation Experience – Esquire

WASHINGTONAh, you may be wondering, is the Republican Senate still installing judges in the federal judiciary with all this other stuff going on, and does this mean that the dark energy powering this administration* will be with us long after the president* goes off to his eternal reward in a sand trap somewhere?

Why, yes. Why do you ask?

Three more were blessed with lifetime employment security on Thursday, and by fairly safe, bipartisan margins, too. (Democrats. Boy, I dunno.) On Wednesday, however, we got a real doozy in one Sarah Pitlyk, yet another Federalist Society drone, and a former clerk to Supreme Court Justice Brett Kavanaugh back when the latter was an annoyance on a lower court. This, despite her being yet another nominee rated unqualified. From the Washington Post:

Most excellent qualifications, and thats not even to mention that Pitlyk holds views on human reproduction that make the College of Cardinals look like Masters and Johnson. Mark Joseph Stern of Slate clued us in on those. Apparently, where many of these people are fetus obsessives, Pitlyk is an embryo obsessive. And, wowser.

Senator Chris Coons, Democrat of Delaware, rose on the Senate floor to point out that the Federalist Society fast-track may well not be the best way to staff the federal judiciary.

Tom WilliamsGetty Images

All of which is true and, of course, completely irrelevant.

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The Senate Just Confirmed a Trump Judge With No Real Trial or Litigation Experience - Esquire

Physical Interventions on the Bodies of Children to Affirm their Gender Identity Violate Sound Medical Ethics and Should be Prohibited – Catholic…

By Ryan T. Anderson and Robert P. George, The Public Discourse, December 8, 2019

Rather than teaching children to identify based on how well they fit prevailing cultural expectations on sex, we should be teaching them that the truth of their sexual identity is based on their bodies, and that sometimes cultural associations attached to the sexes are misguided or simply too narrow. There is a wonderfully rich array of ways of expressing ones embodiment as male or female.

Several weeks ago, many Americans were concerned about a seven-year-old boy in Texas who was the subject of a custody battle after his parents divorced. Fights over the custody of children are always tragic, but what made this one especially disconcerting was that the parents disagreed about medical care for their son. This wasnt just any usual medical decision for a child, where parents need to consider the treatment options and weigh the respective likelihoods of success, potential side-effects, and risks. No, this was a case where the parents favored radically different treatment options because they disagreed about the identitythe genderof their little boy. One of the parents believes the child is actually a girl, a girl trapped in a boys body.

It was this disagreement that led to the bitter battle over treatment. So, without saying anything specific about this childs case, we want to offer readers our best take on what is at stake: the anthropology, ideology, and ethics at issue.

We argue that gender affirmation procedures violate sound medical ethics, that it is profoundly unethical to reinforce a male child in his belief that he is not a boy (or a female child in her belief that she is not a girl), and that it is particularly unethical to intervene in the normal physical development of a child to affirm a gender identity that is at odds with bodily sex.

We argue that gender affirmation procedures violate sound medical ethics, that it is profoundly unethical to reinforce a male child in his belief that he is not a boy (or a female child in her belief that she is not a girl), and that it is particularly unethical to intervene in the normal physical development of a child to affirm a gender identity that is at odds with bodily sex. Childhood and adolescence are difficult enough as it is. Adults should not corrupt the social ecology in which children develop a mature understanding of themselves as boys or girls on the pathway to becoming men or women. Medical professionals certainly should not make radical interventions into the bodies of young people on the basis of a misguided ideology of identity.

We Are Not In Our Bodies, We Are Our Bodies

No one is born in the wrong body, because no one is born in a body. Rather, we are our bodies. There is nothing that could be in the wrong body, for the soul is the substantial form of the bodynot some sort of separate substance.

No one is born in the wrong body, because no one is born in a body. Rather, we are our bodies.

Human beings are not non-bodily persons who inhabit and use non-personal bodies. We are not ghosts in machines. Our bodies are essential aspects of ourselves as the kind of entity we area certain type of animal with a rational nature, a human being. Weyou, I, and every other human beingare personal bodily organisms. And the sex of an organism is determined by how that organism is organized with respect to sexual reproduction. As there are two complementary ways of being sexually organized, so there are two sexes: male and female.

The sexual binary is a biological reality. There is no scientificindeed, no non-ideologicalground for denying it. That some people experience disorders of sexual development, sometimes referred to as intersex conditions, does not negate this reality. Disorders of sexual development do not constitute a third sex or a spectrum of sex. There is no third gamete, no third gonad, no third genital, no third reproductive system. Nor is there a spectrum between the two reproductive systems, despite the reality that these two systems can and sometimes do develop in certain disordered ways. (For more on this, see Chapter 4 of When Harry Became Sally.) It is a red herring to point to physical developmental disorders to justify an ideological view of gender as something fluid, non-binary, and utterly detached from our embodiment as male or female.

Gender Affirmation Is Based on Ideology and Sex Stereotypes

Of course, people can express their sexual identity as male or female in a variety of ways. They can conform to prevailing cultural norms or stereotypes, or they can deviate from them. They may feel comfortable with prevailing cultural expectations for persons of their sex, or they may feel uncomfortable. They can decide to act in a gender non-conforming way, or they can opt to be conventional. None of this, however, changes whether someone is male or female.

And yet, a growing and influential segment of our medical and educational establishments insist that someones sex is merely assigned at birth, and therefore might have been misassigned and can now be reassigned through gender affirming therapies. Here we see ideology calling the tune and scientific fact being shunted aside. According to this ideology, the appropriate determinant of sex is gender identityones putative internal sense of gender (what exactly that is, no one knows, but we are told that gender on this understanding is fluid and exists along a spectrum). When someones gender identity is at odds with his or her body, medical interventions are said to be appropriate and even desirable to align the body with the identity. The claim, made insistently and even indignantly, is that someone who identifies as a woman is a woman (even if shethe pronoun is insisted uponis biologically male), and so medical technology should be used to provide that person with a female body.

This has obvious philosophical problems. If someone who identifies as a woman is a woman, then whatever sort of body that person has already is a womans body. A womans body, on this account, is just whatever body someone who identifies as a woman has. This, after all, is how you get headlines about a womans penis, or a pregnant man. So what is it that the person is aligning the body to?

Why should someone who identifies as a woman abide by stereotypical notions of what a womans body ought to look like? Why should that person take hormones and undergo surgery to conform to those stereotypes? Weve gone from breaking down cultural sex stereotypes to creating an industry in plastic surgery to refashion bodies according to them. And if gender is fluid and exists along a spectrum, what sorts of bodies should gender non-binary or gender-ambidextrous people be given? What sort of hormones and surgery should doctors be providing them? One doctor offers Penile Preservation Vaginoplasty where a neovagina is created while preserving the penis and testicles.

Rather than recognize the incoherence of their worldview, however, those on the cutting edge of gender theory take up this last question and reply: whatever body parts, modifications, and hormones that person desires. As a 2019 Journal of Adolescent Health article put it:

With approximately one-third of TGD [transgender and gender diverse] adults and 40 percent of TGD youth identifying as nonbinary, care guidelines that reinforce binary systems of gender identity may limit access to clinical services and restrict the ability of nonbinary people to navigate medical systems. Framing gender as solely binary defines therapeutic options and outcomes only in reference to two gender experiences, which impacts access.

Moving beyond the binary is the next horizon of medical intervention. It also requires moving beyond medical diagnosis. Indeed, the most recent proposals for gender care assert that it need not be based on any diagnosis of gender dysphoria at all, and should merely operate based on an individuals choiceprovided the individual give informed consent for that choice. According to one recent state report,

Healthcare for TNG [transgender, nonbinary, and gender expansive/nonconforming] youth must be patient-centered and as low-barrier as possible. Informed Consent Models of transition-related healthcare access allow TNG patients to access the essential medical care that they need [sic: desire] without needing to get approval from a therapist or other mental health provider.

So a minors say-so is all it should take to radically transform their bodyeven to the point of causing permanent sterility.

Affirming Falsehoods, Mutilating Bodies

The philosophical problems highlight why this treatment protocol is misguidedindeed, why it violates sound norms of medical ethics. The purpose of medicine is to bring about human health and wholeness, human flourishing in the physical and psychological domains. Here health is understood not as the satisfaction of desires but as the well-functioning of the mind and body, where our various bodily systems achieve their endsthe circulatory system to circulate blood, the digestive system to digest nutrients, the respiratory system to absorb oxygen, etc.and where our thoughts and feelings achieve their ends of bringing us into contact with reality. Thus, any medical intervention intended to affirm someones false beliefs is inherently misguided. Affirming a falsehood via medical technology gets it wrong, right from the start.

It should go without saying that merely because someone identifies as something doesnt necessarily mean that he or she is that thing. Some aspects of reality are determined by how someone identifies, but many aspects of reality are quite independent of our chosen identities. So, sometimes identifying as somethinga Red Sox fan, for examplemakes you that thing. But often it does not. Rachel Dolezals identifying as African-American didnt make her African-American. When she claimed to be African-American, she was saying something that wasnt truesomething that didnt correspond to realityno matter her self-identification. Similarly, identifying as female or as a woman does not make a male a female or a man a womansuch an identity doesnt correspond to reality. What makes someone a woman (or a man) is being a human being (and, as such, a certain type of organism) who is organized for sexual reproduction in a certain way. And so medical professionals who seek to affirm people in a gender identity at odds with reality set themselves about a misguided purpose.

Thats not all. Not only are some medical professionals affirming falsehoods, they are mutilating bodies in the process. So they are deploying bad means (mutilation) in the service of bad ends (affirming falsehoods). Administering high doses of estrogen to a man who rejects his male reality for some alternative identity (whether as a woman, non-binary, gender-ambidextrous, etc.), or administering high doses of testosterone to a woman who rejects her female reality for some alternative identity (whether as a man, non-binary, etc.), or removing reproductive organs and using plastic surgery to create parts or appendages that resemble those of the opposite sex (or neither, or both), mutilates the body in an effort to reinforce false beliefs at odds with reality. This is a misdirection of the medical profession, a violation of sound medical ethics.

Interfering with Childrens Development

Things only get worse when it comes to prepubescent and adolescent children. Whatever one may think about the ethics of medical professionals transitioning adults, everyone should be able to agree that adults should not interfere with the natural, healthy development of the bodies and minds of children. Children must be provided with the time and space to develop to maturity. To tell a child that he or she is of the opposite sex (or both, or neithersomething underwritten today by standard childrens gender books), or to encourage a childs mistaken belief that he is something other than a boy, or she something other than a girl (however sensitively one may, and should, be handling such a situation), is deeply unjust to that child. To intervene in a childs physical development, to block the child from going through normal pubertyall in an attempt to affirm a gender identity that rejects bodily realityis profoundly unethical.

Adults should not interfere with the natural development of a childs body to alter its appearance based on ideology. Yet that is precisely what many medical associations now advocate. They prescribe a four-part treatment protocol starting in early childhood for transgender and gender diverse children: social transition, puberty blockers, cross-sex hormones, and surgery.

These guidelines are based on a faulty philosophical anthropology, a misguided understanding of the purpose of medicine, and virtually no scientific evidence. Indeed, the Endocrine Societys official statement promoting this treatment protocol notes that all six of their treatment recommendations for adolescents are based on low or very low quality evidence. Even apart from the philosophical and ethical problems with the treatment protocol, there is a glaring medical science problem: how can such a radical medical plan to transform childrens bodies be promoted based on research of such poor quality? Part of the explanation is that the medical associations as a whole have not embraced these standards, but ideologically driven subcommittees within those associations have taken it upon themselves to promulgate them.

Five Points to Remember

So what more can we say about these interventionsstrictly speaking, these non-medical interventionson the bodies of young people?

1. Experimental

First, these procedures are entirely experimental. There is not a single long-term prospective study of the long-term consequences of blocking an otherwise physically healthy child from undergoing normal pubertal development. Indeed, the drugs being used to indefinitely delay normally timed puberty are not FDA-approved for this purpose and are being used off-label. While we know certain negative consequences of this sort of long-term puberty-blockingincreased risk for low bone density, shorter height, and reduced memorywe simply have no idea what all of the physical and psychological consequences are. Theres no way of knowingapart from conducting this experiment on the bodies of young people. That itself is unethical human experimentationand on children. We wont know the full consequences for twenty or thirty or forty or more years. Furthermore, the clinics conducting these experiments are typically not appropriately classifying them as experimental. They are neither disclosing this to patients and families nor seeking Institutional Review Board (IRB) approval, which is necessary for all experimental research on human subjects.

2. Irreversible

Second, parents are told that these procedures are fully reversible, but that is not true. Going off of puberty-blocking drugs, with the hope that development resumes, does nothing to reverse the delayed biologically appropriate development. You cant go back in time and reverse that delay. That said, as an empirical matter, virtually all children placed on puberty-blocking drugs as part of gender affirmation care go on to receive cross-sex hormones, continue to identify as of the opposite sex, and attempt to make their bodies appear as if of the opposite sex. The end result is sterilization. And so it is entirely accurate to say that placing a child on puberty-blocking drugs as part of a gender affirming intervention is to set that child on a pathway to irreversible, permanent infertility. This is something no child can fully understand, let alone consent to.

3. Self-Fulfilling

Third, many experts fear that these treatment protocols are self-fulfilling. Telling a little boy that he is a girl (or something else) or a girl that she is a boy (or something else), blocking his or her natural biological development into a man or a woman, and then flooding him or her with opposite-sex hormones will simply reinforce false beliefs. Indeed, it may very well be pubertal development that helps young people feel comfortable in their own bodies. Imagine the rush of testosterone, growth spurt, and maturation into a mans body and how it may help a young boy feel comfortable as a man. Indeed, 80 to 95 percent of young people with a gender identity conflict will naturally reconcile their identity with the body if their development is not interfered with. By comparison, 100 percent of children in a Dutch study who were placed on puberty blockers went on to receive cross-sex hormones. Puberty blockers, rather than buying more time to decide, seem to lock in transgender identity.

4. Lack of Diagnostic Rigor, Especially for Immature Children

Fourth, while the diagnosis that someone is of the opposite sex is medically and scientifically baseless, it is particularly outrageous when applied to children. On what other issue do we allow a childs self-assertion to be the basis for such life-altering decisions, or to allow children to undergo such permanent changes to their bodies? Children lack the experience and cognitive abilities even to know what it means to be a boy or a girl, a man or a woman. And yet gender experts tell parents that if a child is persistent, insistent, and consistent in asserting that he or she is of the opposite sex (or neither, or both), that means he or she is of the opposite sex (or neither, or both). This is nonsense. Of course gender dysphoriaa feeling of distress at ones bodily sexis a very real and serious condition. All sexual confusion is. It deserves compassion and proper treatment, treatment to help a patient feel comfortable with his or her own body. But experiencing gender dysphoria or other sexual confusion doesnt make someone of the opposite sex. Or both sexes. Or neither sex.

Driving the diagnoses of the gender experts are ideological judgments based on stereotypes. Leading gender experts claim that nonconformity to sex stereotypes is a sign of someones true gender identity. For example, when asked how one- or two-year-old, pre-verbal children could communicate their true gender identity, Dr. Diane Ehrensaft, the Director of Mental Health of the Child and Adolescent Gender Center at the University of California, San Francisco, gave the following answer: I have a colleague who is transgender. And there is a video of him as a toddlerso he was assigned female at birththeres a video of him as a toddler tearing barrettes out of then-her hair. And throwing them on the ground. And sobbing. Thats a gender message. Ehrensaft continued:

Sometimes kids between the age of one and two, with beginning language, will say, I BOY! when you say girl. Those two words. Thats not a pre-verbal, but an early verbal message. And sometimes theres a tendency to say, Well, honey, no youre a girl because little girls have vaginas, and you have a vagina so youre a girl. And then when they get a little older youll hear them say, Did you not listen to me? I said I am a boy with a vagina. Ok, but they cant say that between one and two. But they can show you about what they want to play with and if they feel uncomfortable about how you are responding to them and their gender, if youre misgendering them.

This is the sort of diagnostic rigorself-reports of gender from childrenthat leads medical doctors to make these drastic interventions into the bodies of young people. Rather than recognize that children at early developmental stages are simply too immature even to understand what makes someone a boy or a girl, this diagnostic approach simply reifies internal feelings based on limited human experience and knowledge. From a scientific and medical perspective, what does it even mean to say someone is a boy with a vagina? What does it mean to be a boy in such an ideology? And yet, doctors are using medical technology to profoundly mutilate the bodies of young peopleall because they say they are boys with a vaginaand surgeons believe they can create something that would resemble a penis. Though, as we mentioned above, why a boy needs a penison this ideological understanding of genderis never explained. Adults in the medical profession are exploiting the confusion of children.

We could readily supply countless additional examples of this gender-affirming approachattempting to diagnose an impossibility (being trapped in the wrong body, being a boy/girl) based on an ideology founded on stereotypes (internal sense of gender), all disclosed by children who lack the bodily development, intellectual capacity, and social experiences even to know what it means to be fully male or female. But perhaps one more example will suffice for now. Johanna Olson-Kennedy, the Medical Director of The Center for Transyouth Health and Development at the Childrens Hospital of Los Angeles, describes how she helped an eight-year-old girl discover she was really a boy:

I said, Do you ever eat pop tarts? And the kid was like, oh, of course. And I said, well you know how they come in that foil packet? Yes. Well, what if there was a strawberry pop tart in a foil packet, in a box that said Cinnamon Pop Tarts.? Is it a strawberry pop tart, or a cinnamon pop tart? The kids like, Duh! A strawberry pop tart. And I was like, so And the kid turned to the mom and said, I think Im a boy and the girls covering me up.

This is body-self dualism on full display. The body is just the foil packet of the real self, the machine in which the ghost resides. This is the sort of expert advice dished out by medical directors of leading gender clinics.

This same embrace of dualism has led Olson-Kennedys clinic to perform double-mastectomies on thirteen-year-old girls. Its this same embrace of dualism that led Olson-Kennedy to cavalierly dismiss concerns about transition regret: And heres the other thing about chest surgery: if you want breasts at a later point in your life you can go and get them. She dismisses concerns about the cognitive capacity of adolescents to make such life-altering decisions, with sheer assertion: Actually, people make life-altering decisions in adolescence. All the time. All the time. . . . What we do know is that adolescents actually have the capacity to make a reasoned, logical decision. Oh, and those thirteen-year-old double-mastectomies took place as part of an NIH-funded study that Olson-Kennedy is leading on transitioning children.

5. Reassignment Doesnt Produce Good Outcomes

Fifth, and finally, not only is sex reassignment physically and metaphysically impossible, it doesnt even produce good psychosomatic results. So even if you disagreed with us about the philosophy of the body and the medical ethics of transitioning, you would still need to be concerned that an entirely experimental, self-fulfilling treatment protocol that is based on nonsensical diagnostic criteria doesnt even produce the desired outcomes of happiness and wholeness. Forty-one percent of all adults who identify as transgender attempt suicide at some point in their lives, and adults who have had sex reassignment surgery are nineteen times more likely than the general population to die by suicide. These outcomes are unacceptable. And the best research shows that reassignment procedures do little to nothing to improve well-being.

As even the Obama Administration reported in 2016, the best studies of sex-reassignment procedures did not demonstrate clinically significant changes or differences in psychometric test results after the reassignment. A large, long-term data set from Sweden released just this year (2019) shows a similar result: hormonal transition produced absolutely no mental health benefits for those patients. Meanwhile, the data from that study demonstrate that the beneficial effect of surgery for transgender people is so small that a clinic may have to perform as many as 49 gender-affirming surgeries before they could expect to prevent one additional person from seeking subsequent mental health treatment. Imagine suffering so much, feeling so uncomfortable with your own body that you would contemplate transitioning, and then receiving virtually no improvement. If these are the results of transitioning, why would anyone encourage a child down this path?

What Children Need

Children who feel deep discomfort with their bodily sex should be treated with kindness, respect, compassion, and love. They need to be protected from bullying, teasing, discrimination, and any form of mistreatment. They are precious human beings who need to be given whatever assistance we can give to help them feel comfortable with their bodies.

This includes providing counseling for any underlying trauma or for social dynamics at home or school that may play a role in the dysphoria. And it includes helping them to break down misguided sex stereotypes or cultural expectations that may underlie their dysphoria. But it must also entail a resolute refusal to go along with ideologies that reinforce sex stereotypes. Preferring the color pink or playing with dolls does not make someone a girl. Rather than teaching children to identify based on how well they fit prevailing cultural expectations on sex, we should be teaching them that the truth of their sexual identity is based on their bodies, and that sometimes cultural associations attached to the sexes are in fact misguided or simply too narrow. (On this last point, see Chapter 7 of When Harry Became Sally.) Girls can like football and hunting without being boys or nonbinary. There is a wonderfully rich array of ways of expressing ones embodiment as female.

Prudent legislation is needed to prevent adults from interfering with a childs normal, natural bodily development. Gender affirmation procedures violate sound medical ethics. It is profoundly unethical to intervene in the normal physical development of a child as part of affirming a gender identity at odds with bodily sex. While puberty-blocking drugs may be an appropriate treatment for precocious pubertythe early onset of pubertyin order to delay puberty to a biologically appropriate age, that is not what is going on here. The use of puberty blockers to delay or permanently block natural biological puberty is unethical and violates the rights of children to bodily integrity. Administering cross-sex hormones to minors, in an attempt to make their bodies cosmetically resemble those of the opposite sex or of their preferred gender identity, is likewise a violation of sound ethical norms and the rights of minors. Surgically removing genitals or secondary sex characteristics in an effort to affirm a gender identityas done to those thirteen-year-old girls who underwent double-mastectomies in taxpayer-funded researchis particularly heinous. Governments should prohibit this misuse of medical technology and protect children from these harms.

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Physical Interventions on the Bodies of Children to Affirm their Gender Identity Violate Sound Medical Ethics and Should be Prohibited - Catholic...

A Masterful Charles White Painting Could Smash the Artists Auction Record, But Lets Not Forget That He Was Devoted to Making Art for the Masses -…

One of the key points that Barbara Jones-Hogu made in her 1973 manifesto for the influential group that went by the unforgettable name African Commune of Bad Relevant Artists Work (or AFRI-COBRA for short) was that black artists should ensure that their work was accessible to their audiences. She didnt just mean what artists drew, printed, painted or sculpted; she also meant artists ensuring that their work, or reproductions of it, were within easy reach of the people with whom it was intended to dialogue.

Jones-Hogu stressed the importance of modes of expression, that lend themselves to economical mass production techniques such as Poster Art so that everyone who wants one can have one. Jones-Hogu may well have been mindful of the strategies of audience engagement pioneered by the renowned American artist Charles White, whose work is becoming ever more celebrated, as two current exhibitions on the campus of the University of Texas at Austinat the Blanton Museum of Art and the Christian-Green Galleryattest.

Relatively speaking, Whites work has consistently achieved respectable prices at auction. How could they not? With his work widely reproduced in print, and featuring in so many published or exhibited histories of African American art, the chance to own a Charles White original is something many collectors are keen to do. Even so, this months auction at Christies New York of one of the artists lesser known works, Banner for Willie J., a 1976 oil painting, will be something of a milestone, because the work carries an estimate of between $1 million and $1.5 million.

No doubt the escalation in appreciation of Whites work, in part a consequence of his major exhibition that traveled from Chicago to New York to Los Angeles, has helped increase valuations of his originals, but we still might be tempted to think that such financial appraisals are overdue. Banner for Willie J. is a beautiful, hugely engaging work, instantly recognizable as coming from the artists mid-1970s period, and its a work that has wider stylistic similarities with Homage to Sterling Brown, produced a few years earlier. Both have a lyricism, a deep affection for the black male figure, and Whites characteristic attachment to depicting human anatomy. The price that Banner for Willie J. might realize could significantly exceed the handsome prices his work has already been achieving at auction in recent years.

Charles White, Banner for Willie J. (1976). Courtesy of Christies Images, Ltd.

Yet we shouldnt let the excitement over this high-profile work obscure one the most salient aspects of Whites practice: that he was steadfastly committed to making art accessible to all, a pursuit he achieved by mass-producing his images on book jackets, record sleeves, and other printed materials.

Born in Chicago in 1918, White, who died at the relatively young age of 61, was a highly accomplished draughtsman, painter, printmaker, and muralist. He dedicated his life to his art, which was characterized by his commitment to depicting African Americans as dignified, resilient survivors, and to this end, his drawings of black Americans resonated with hope, fortitude, humanity, and pride.

With a highly distinctive drawing style, Whites recent exhibitions have firmly, though belatedly, established him as one of the most respected and admired American artists of the 20th century. His drawings, though in some respects hugely accessible, were nuanced creations embodying many layers of meaning, history, and culture.One of Whites strategies was to produce folios of reproductions of his drawings, and he saw to it that at least six different folios were brought into existence over the course of a career cut short by illness. These folios attested to his determination to see his work brought within reach of those who could ill afford gallery prices and may well have been somewhat alienated from the world of art galleries and museums.

Charles Whites Awaken from the Unknowing (1961) on the cover of Freedomwaysjournal, a quarterly review of the freedom movement. Collection of Eddie Chambers.

The first of these folios was issued in 1953 and contained reproductions of what were already widely regarded as classic works by White. Remarkably, the folio cost a mere $3, which even in todays money is somewhere in the region of just $30. The other folios, published over the next couple of decades, were similarly modestly priced. It is, however, Whites prolific work as an illustrator of record sleeves, book jackets, and so on that is perhaps the least remembered or appreciated aspect of his work, even though such reproductions were the means through which many African Americans came to know and love the artist. Poet Nikki Giovanni perfectly expressed the affection many people have for Whites images, in her poem named for the artist: Charles White and his art were introduced to me through magazines and booksthats why I love them.

No other artist lent more reproductions of their work to book jackets, magazine covers, and record sleeves than White. With their potency, articulation, and awesome visual beauty they are an absolute pleasure to behold. Given Whites particular appreciation of black culture in its many forms, including black American music, his evocative, poetic drawings were perfect for the sleeves of the jazz records they frequently came to adorn. Make no mistake, these were beautifully crafted images that not only functioned perfectly as distinct drawings (at a time when photography and graphic design were increasingly being deployed in the service of record sleeve illustration), but also managed to directly dialogue with the music of the records themselves.

White supplied drawings for a number of Vanguard label records, for the most part with 10-inch sleeves. Now, in 2019, seeing the record sleeves of these jazz and blues recordings we can appreciate just how wonderful a draughtsman White was, and just how committed he was to bringing his work to wider audiences. Though Whites work gained widespread appreciation from the 1940s onwards, he took time during his particularly productive mid-20th century years to undertake these record sleeve commissions.

Drawing by Charles White on the cover of Brother John Sellers, Jack of Diamonds (ca. 1954) record. Collection of Eddie Chambers.

Not infrequently, his successes as an artist were noted on the backs of the record sleeves he had illustrated, with words such as:

The drawing on the cover is one of a series commissioned by Vanguard Recording Society, Inc., from the distinguished American artist, Charles White, for use on its Jazz Showcase and classical releases. Aside from our belief that it takes a creative artist to capture the full human feeling of creative music, we hope by this means to bring to the public a knowledge of contemporary American art such as this, which has only to be seen to be loved. Charles White won the Julius Rosenwald Fellowship in 1942, an Academy of Arts and Letters Award in 1952, and a National Prize of the Metropolitan Museum of Art in New York. His work is represented in the Whitney Museum, Library of Congress, and other famous collections.

Like Whites art itself, his record sleeve illustrations were every bit as committed to portraying African Americans as dignified and resilient, with his images resonating with hope, fortitude, humanity, and culture. And because what I refer to as Whites 10- and 12-inch messages came directly into peoples homes, individuals could appreciate the crosshatching, exquisite draughtsmanship, and perfect compositions of his drawings, without having to stand behind a gallery barrier, or be separated from a drawing or print by glazing. Within the Charles White exhibitions on the University of Texas at Austin campus, seeing a work such as Awaken from the Unknowing (a drawing of a young African American woman, studying, her copious papers spread across the table at which she reads) and, a short distance away, being able to see the same drawing, reproduced in miniature, on the cover of Freedomways journal is indeed a special experience in which a remarkable dialogue is created between the two images, one an original, the other a much smaller reproduction.

Would that more artists of the present time had such a singular, broad-based commitment to sharing their work with multiple audiences. It is perhaps extraordinary that such a dynamic aspect of Whites practice has received relatively little scholarship. Perhaps that will change.

Professor Eddie Chambers joined the department of art and art history at the University of Texas at Austin in 2010, teaching African Diaspora art history. He is the editor of the forthcomingRoutledge Companion to African American Art History.

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A Masterful Charles White Painting Could Smash the Artists Auction Record, But Lets Not Forget That He Was Devoted to Making Art for the Masses -...

Human Reproduction – Leaving Certificate Biology Free …

As in all other organisms reproduction is the formation of new individuals of the same species. Sexual reproduction is the only method of reproduction in our species. Sexual reproduction involves the fusion of specialised haploid sex cells. The fusion of sperm and egg cell is called fertilisation. Fertilisation results in the formation of a diploid zygote from which a new individual develops.

Both the male and female reproductive structures have 3 levels of organisation:

1. Production of sex cells.2. Transport tubes.3. Glands to secrete hormones.

The gonad is the name for the organ that produces sex cells in organs. The male gonads are called the testes.The testes are contained in the scrotum.

The testes produce the sperm cells by meiosis. The temperature must be lower than body temperature for this to occur. There are tubules that are lines with sperm producing cells. Testosterone, the male sex hormone, is also produced in the testes. Once the sperm are produced they mature in the epidymis. This structure is located outside of the testis. If they are not released within about 6 weeks they are broken down and released to the bloodstream by a process called resorption. The sperm are carried to the urethra by the sperm duct. The urethra carries both sperm and urine.

The sperm cells are carried within a liquid called semen. The semen is produced by the seminal vescicles, theprostate gland, and Cowpers glands. The semen also contains nourishment for the sperm cells.

Sperm cells are released by ejaculation. About 50-300 million sperm cells are released at one time.

Sperm cells, also called spermatozoa, are haploid containing 23 chromosomes. Their production begins at puberty.

The penis is adapted to place sperm cells into the female. The tip is called the glans. Erection occurs when blood rushes into the penis.

Male hormones are produced by the pituitary gland during puberty. They are:

FSH- Follicle Stimulating Hormone: This causes the production of sperm by meiosis.LH- Leuteinising Hormone: Stimulates the testes to produce testosterone.

During the period of pregnancy testosterone causes the development of primary male sex characteristics. These include the development of the penis and the other male reproductive parts.

Later in life, at puberty, testosterone causes the enlargement of the reproductive parts as well as the development of secondary sexual characteristics. These are characteristics that distinguish males from females.

Male secondary sexual characteristics included:

1. hair growth on the face, underarm, chest and pubic region2. enlarged larynx producing a deeper voice3. wider shoulders4. greater skeletal muscular development5. growth in height and weight

The most common cause of male infertility is the low production of sperm. There are many causes of low sperm production. Stress, alcohol and drug abuse, high temperature of the testes, and low testosterone production are all causes.

Ovaries produce eggs and female hormones. At puberty there are about 40,000 diploid eggs. Each egg is enclosed in a group of cells called a follicle. About 20 haploid eggs are produced each month. Usually all but one die. The haploid egg cell is called the ovum and is surrounded by the Graafian follicle which produces the female hormone called oestrogen. Ovulation is the release of the egg from the follicle. This occurs when the follicle bursts.

The fallopian tubes are about 12 cm long and have ends that are funnel shaped. These ends collect the egg after ovulation. Cilia and peristalsis move the egg along the tube. The egg will die in the tube if it is not fertilised.

The uterus, also known as the womb, is made of involuntary muscle. It is lines with the endometrium. This lining thickens with cells and blood every month. This happens in order to nourish the embryo (if present). The opening of the uterus is called the cervix.

The vagina is a muscular tube which allows the sperm to enter the female as well as the baby to exit. It is lined with mucous secreting cells. The urethra opens near the vagina. The vagina is protected by folds of skin called the vulva. The hymen partially blocks the entrance of the vagina. It is broken by sexual intercourse or with the use of tampons.

The menstrual cycle occurs every 28 days from puberty to menopause (the end of the females reproductive life). It occurs only if fertilisation of the egg has not taken place.

The typical events of the menstrual cycle are:

Day 1 to day 5-

a. The endometrium breaks down and is shed from the body. This is called menstruation.

b. Meiosis occus in the ovary to produce a new egg surrounded by the Graafian follicle.

Day 6 to day 13-

a. Oestrogen is produced by the Graafian follicle. Oestrogen also stimulates the endometrium to thicken again. One Graafian follicle with one egg develops.

b. Oestrogen stimulates the production of LH (leuteinising hormone)

Day 14-

a. The surge of LH stimulates ovulation.

b. The egg enters the funnel of the Fallopian tube. It can be fertilised for the next 48 hours.

Day 15 to day 26-

a. The corpus luteum (yellow body) develops from the remains of the Graafian follicle. This produced progesterone and some oestrogen. The progesterone causes the endometrium to continue to thicken. It also prevents new eggs from forming.

b. The egg that was released at day 14 will die if it is not fertilised.

c. If fertilisation did not take place the corpus luteum begins to degenerate.

Day 26 to day 28-

a. Oestrogen and progesterone levels decline.

b. The endometrium begins to break down.

c. Day one of the cycle begins.

In summary:

Endometrium thickened by oestrogen in days 1-14 and by progesterone in days 15-28.

Both prevent egg development.

At puberty, oestrogen causes the primary female sexual characteristics of the growth of the sex organs. At puberty both oestrogen and progesterone cause the secondary female characteristics.

They include:

a. The enlargement of the breastsb. Widening of the hipsc. Increased body fatd. Growth of public and underarm haire. General growth spurt in height

HORMONE

SITE OF PRODUCTION

TIME OF PRODUCTION

FUNCTIONS

FSH-follicle stimulating hormone

Pituitary Gland

Days 1-5 of menstrual cycle

Stimulates egg production withinGraafian follicles.

Sometimes used in fertilitytreatment to stimulate egg production.

Graafian follicles secreteoestrogen.

Oestrogen

Graafian follicle

Days 5-14 of menstrual cycle

Development of endometrium.

Inhibits FSH so no new eggsdevelop.

Stimulates the release of LH(luteinising hormone).

LH- leuteinising hormone

Pituitary Gland

Day 14 of menstrual cycle

Causes ovulation.

Causes Graafian follicle to developinto the corpus luteum. The corpus luteum makes progesterone.

Progesterone

Corpus luteum

Days 14-28 of menstrual cycle

Maintains endometrium.

Inhibits FSH so no new eggsdevelop.

Inhibits LH so no new ovulationsoccur.

Prevents contractions of the uterus.

Female infertility is the inability to conceive either by fertilisation failure or implantation failure. Egg cell formation or ovulation may not occur due to a hormone imbalance. The egg cell may not be able pass to the uterus due to blockage of the Fallopian tubes. Treatment with hormones may be successful. In-vitro fertilisation and implantation is often used to treat female infertility.

Fibroids are benign tumours of the uterus. They are slow growing and range in size. Small fibroids produce no symptoms while large ones can cause heavy and prolonged menstrual bleeding. They can also cause pain, miscarriage, or infertility. Some science shows that they may be caused as an abnormal response to oestrogen. Large fibroids are removed by surgery. In severe cases where there are many large fibroids the uterus may have to be removed. This is called a hysterectomy.

Copulation is also called coitus or sexual intercourse. During this process the penis moves into the vagina in order to deposit semen which contains sperm cells. The depositing of the semen is called insemination.

a. After insemination the sperm will move up the Fallopian tubes.b. If ovulation has occurred and an egg is present the egg will release a chemical that attracts the sperm. This is called chemotaxix.c. The sperm that reaches the egg will use an enzyme in its acrosomes to make an opening in the membrane of the egg.d. Once one sperm enters the egg (only the head enters) the egg forms a membrane that prevents other sperm from entering.e. The nucleus of the egg fuses with the nucleus of the egg. A diploid zygote forms.f. Fertilisation may take place during days 11-16 of the menstrual cycle.

About 6-9 days after fertilisation the fertilised egg becomes embedded into the lining of the uterus. The zygote has now become an embryo. A membrane called the amnion develops around the ebbryo. This membrane will secrete amnion fluid which surrounds and protects the embryo.

a. After implantation the embryo forms another membrane called the chorion. This surrounds the embryo.b. Projections of the chorion called villi join with blood vessels in the endometrium to form the placenta.c. The placenta become fully functional in about 3 months.d. The umbilical cord connects the embryo (at the navel) with the placenta.

1. Protection of the Embryo:

A. It hinders the entry of pathogens from the mother.B. It allows the entry of antibodies from the mother (passive induced immunity).C. It keeps the embryo separated from the mothers higher blood pressure.D. It prevents exchange of red blood cells avoiding the deadly possibility of agglutination

2. Gas Exchange:

A. It supplies O2 from the mother.B. It excretes CO2 from the embryo to the mothers blood.

3. Nutrient Supply:

Glucose, amino acids, lipids, vitamins and minerals pass to the embryo from the mothers blood.

4. Endocrine:

It secretes a variety of hormones including oestrogen and progesterone. The hormones maintain the pregnancy and prepare the mothers body for birth and lactation.

5. Excretion:

Metabolic wastes, CO2 and urea, pass from embryo into the mothers blood.

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Human Reproduction - Leaving Certificate Biology Free ...

A Power Teacher Duo Gives Back With Brooklyn Cares – BKLYNER – BKLYNER

Levin with her kids holding the Brooklyn Cares logo on their stoop. (Photo via Levin)

BROOKLYN HEIGHTS Two teachers from the private St. Anns School are giving back to their community during the coronavirus pandemic by fundraising, organizing, and donating meals to essential workers all while teaching virtually full-time. They call it Brooklyn Cares.

During the early days of the coronavirus, Michele Levin, 41, had reached out to her former colleagues at Columbia Childrens Hospital of New York asking if they needed volunteers Levin was once a practicing pediatrician. At the time, they told her they werent in need of extra hands in pediatrics, so, she began talking with her colleague Stephanie Schragger, 48. Both of them co-teach an interdisciplinary class at Saint Anns School for high school juniors and seniors called Sex: A Historical and Biomedical Exploration of Human Reproduction, though they acknowledge that students often refer to it simply as Sex.

Schragger and Levin wanted to find a way to help out frontline workers who were risking their lives, and local restaurants that had been hurt economically. Levin had gone to Harvard Medical School and completed residency training in Pediatrics. Schraggers husband is a non-clinical worker who was initially working late nights at New York-Presbyterian Hospital. For both of them, it was personal.

So three weeks ago, they came up with Brooklyn Cares.

In these weeks, the two teachers have raised over $16,000, delivered over 1,000 meals, working with local restaurants who do the cooking. About 300 of those meals were delivered to Cobble Hill Health Center, a local nursing home hit hard by COVID-19, others have gone to University Hospital of Brooklyn- SUNY Downstate, NYC Health + Hospitals/Kings County, Maimonides Medical Center, NYU Langone Hospital- Brooklyn, NYC Health + Hospitals/Bellevue, and Manhattan VA Medical Center.

Where do these meals come from? Local restaurants. So far, they have worked with Bar Toto, Purslane, Kitchen at Cobble Hill, La Vara, Insa, Butler, and Mile End Delicatessen. They plan on expanding to others soon.

Living in a building of health care workers and hospital employees, Ive talked to so many people who are working grueling hours, under unimaginably stressful conditions to help those patients fighting COVID-19, Schragger said. I wanted to help out hospital workers in any way possible, and helping to donate meals felt like a productive way to show support since I couldnt help out in person. I also really value the way that local restaurants bring so much life and vibrancy to Brooklyn neighborhoods, and I wanted to do anything I could to help them to survive.

Schagger and Levin dont pick up and deliver the meals alone; St. Anns psychologist Liz Bernbach and nurse Pumpkin Wentzel help them out. With a goal to provide at least 1,500 meals by the end of this month, it seems this power duo plans on getting no sleep but to them, its all worth it.

Levin lives in Cobble Hill. A former teacher, she returned to the classroom about eight years ago after doing her residency in Pediatrics. Along with co-teaching with Schagger, she also teaches Science and is the tenth-grade dean. For Levin, it was frustrating not to be able to spring into action and put her medical training to use, but she soon directed her energy to teaching, being a mother, and helping those in need.

Its been very, very busy trying to plan this fundraiser while teaching full time and also helping with virtual schooling at home for our children, she said, but it has made both of us feel a sense of purpose and pride in being able to contribute to our communities in this one small way during such an incredibly difficult time for so many here in our city.

Schragger lives on the Upper East Side. Shes been teaching history at St. Anns School since 2002. She too juggles work with being a mother with her efforts of giving back. For her, its about putting frontline workers in the spotlight.

I feel like health care workers are starting to be seen as the heroes that theyve always been, and I hope that this support and respect will continue well beyond the COVID-19 pandemic, she said. Ive also been so touched by the outpouring of support and kindness that weve already received from the restaurants that weve worked with, as well as the friends, family, and even strangers who have supported our fundraiser.

There are a lot of really wonderful people working to help and a tremendous amount of community strength here in Brooklyn and throughout New York City, Schragger continued. Im hopeful that New York City can continue to do everything possible to make its way through these trying times.

And no matter how hectic it all gets, these teachers want to continue giving back. They feel as if it is their duty to do so.

Rainbows in our windows to brighten the world of children walking by, clapping and ringing bells in support of our healthcare workers at 7 p.m. each night there is such a sense of togetherness and community here in Cobble Hill, Levin said, and finding a way to contribute to these efforts and support healthcare workers, as well as restaurants and their staff here in our neighborhood is what planted the seed for us that has grown into Brooklyn Cares.

To donate, check out their GoFundMe page.

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A Power Teacher Duo Gives Back With Brooklyn Cares - BKLYNER - BKLYNER

CBSE Class 12 Biology || Human Reproduction || Full Chapter || By Shiksha House

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In clinical trials and laboratories, the hunt is on to find vaccines and drugs to treat, prevent novel coronavirus – 60 Minutes – CBS News

With the novel coronavirus extending its shadow of illness and death globally, the U.S. Food and Drug Administration and the National Institutes of Health are now slashing red tape to expedite research so promising vaccines and therapies can be developed as quickly as possible. To date there is no proven medical way to stop this coronavirus - no treatment, no vaccine. The best defense has been tried-and-true public health measures: social distancing and hand washing. But the rapid spread of the deadly virus prompted medical researchers the world over to go on offense. Old medicines are being dusted off and repurposed, new vaccines are being developed in government and commercial labs. We went to Omaha, Nebraska, where one of those drugs is being tested on some of the sickest American patients.

At the University of Nebraska Medical Center, one of the eerier scenes we've witnessed in recent weeks. Cocooned inside that bubble, called an isopod - a 36-year-old woman - unlucky to have been infected with the new coronavirus, but lucky to be here. This facility was one of the first in the country built for outbreaks like this. Some of the sickest patients from the Diamond Princess cruise ship were taken there. Quarantined in Yokohama, Japan, more than 700 passengers and crew contracted the virus, including 67-year-old American Carl Goldman. He was quarantined here for a month. We had to talk to him through thick glass.

Carl Goldman: When we landed in Omaha, more officials came onboard with hazmat suits. They unloaded me, put me on a stretcher. They were wheeling me through passageways that were deserted then up an elevator, and then into a room that was set up as a bio-containment room.

Bill Whitaker: They moved you to a bio-containment room?

Carl Goldman: Yeah.

Dr. Angela Hewlett is the medical director of the bio-containment unit, equipped to care for patients with highly contagious, dangerous diseases. Built in response to the 2001 anthrax scare, the unit is isolated from the rest of the medical center, with its own ventilation system, security access and highly trained staff: about 100 nurses, therapists, critical care and infectious disease doctors.

Bill Whitaker: How many patients can you treat at one time?

Dr. Angela Hewlett: We could actually accept up to probably eight patients in the biocontainment unit, totally dependent on how sick they are and how much equipment is required.

Bill Whitaker: How many facilities like this are there around the country?

Dr. Angela Hewlett: We have 10 regional treatment centers with those capabilities.

Bill Whitaker: Given the scope of this outbreak, that doesn't seem nearly enough. And when I see the Isopods being used to bring people into this facility, that makes me think that this is pretty bad.

Dr. Angela Hewlett: If we had a-- a therapeutic agent that we knew worked or if we had a vaccine that could help prevent the spread of this illness, then-- you know, then this would be something a little more controllable than what we have now.

Researchers at the University of Nebraska Medical Center modeled a worst case scenario in the U.S.: over the course of a year, 96 million cases of COVID-19; 4.8 million hospitalizations; almost a half-million deaths. Scientists hope the measures the country is taking will keep the worst from happening, but the urgency of this moment has medical researchers all over the world racing to find some way to fight the killer virus. Last month, the National Institutes of Health tapped the Nebraska Medical Center to launch the first clinical trial in the U.S. of an antiviral drug, remdesivir, which is administered intravenously to treat patients who have already contracted the virus. It's being tested against a placebo.

Dr. Angela Hewlett: It was actually studied in Ebola, interestingly. Didn't work as well for Ebola. However-- there have been some animal studies as-- as well as some studies in the lab that demonstrate that it worked fairly well against illnesses like SARS and MERS, which are also coronaviruses.

Bill Whitaker: How does the drug work?

Dr. Angela Hewlett: It inhibits replication of the virus and so when a virus would normally try to reproduce itself, this drug inserts itself into that process and then stops viral replication, so it stops reproduction of the virus.

Bill Whitaker: This clinical trial is up and running in the middle of this outbreak.

Dr. Angela Hewlett: I will say this is the fastest clinical trial that I've ever seen come to-- to fruition in this amount of time.

Bill Whitaker: Ordinarily, how long would it take to get a trial up and running?

Dr. Angela Hewlett: that can range from many months to-- to years.

The maker of the anti-viral, remdesivir, Gilead Sciences in California, is ramping up production to provide multiple clinical trials in the U.S., Asia, and Europe. The U.S. Army also is testing the drug.

With no proven treatments, hundreds of trials of different drugs are underway worldwide. Researchers in the U.S. and China are investigating whether the common anti-malarial drug Chloroquine and related drugs might inhibit the virus. In New York, Regeneron Pharmaceuticals is testing a cocktail of antibodies to see if they can temporarily boost immune systems to fight the virus. Scripps Research in San Diego is using a robot to go through its extensive library of existing drugs looking for antiviral compounds to send to labs around the world to test if any combination might prove effective in combating the new coronavirus and quell the pandemic.

Kate Broderick: I can't express to you the pressure-- that I personally feel under, and I think the whole scientific community feels under. There's a great deal of responsibility-- in working towards a solution for this outbreak, literally as it's happening.

Scottish born Kate Broderick is Senior Vice President of Research and Development at Inovio Pharmaceuticals in San Diego. Employees are working against the clock to create a vaccine to prevent people from ever getting the virus. Inovio is using DNA biotechnology, cutting edge science that has yet to produce a marketable vaccine.

Bill Whitaker: How optimistic are you that this is the solution?

Kate Broderick: I feel very confident in the technology that we've developed here at Inovio. And I feel very cautiously optimistic that our vaccine will be effective when we test it in the clinic.

Inovio has already started testing its vaccine on animals and expects to start human trials next month. The company's race to create a vaccine was triggered by this: the genetic sequence of the new coronavirus. Chinese scientists posted it online just weeks after the outbreak was identified.

Kate Broderick: all we need is that genetic code. So it's just a series of A's, and T's, and C's, and G's that make up the blueprint to the virus. We use a computer algorithm to generate the design of the vaccine. So we plugged in the viral sequence. And after three hours, we had a fully designed vaccine on paper. And then, after that, the stages to manufacture went straight into effect.

Bill Whitaker: Three hours?

Kate Broderick: Yeah, absolutely.

Bill Whitaker: Is that unusually fast?

Kate Broderick: Certainly, if you're thinking of traditional vaccines. They take months to years.

Using the genetic code, Inovio scientists are able to zero in on the part of the deadly virus, these spikes, that attach to human cells. They then recreate that bit of coronavirus DNA in the lab. The synthetic snippet of virus is grown inside bacteria. After sloshing around all night, there are thousands, if not millions of copies of the synthetic DNA. Filtered and processed it looks like this. The vaccine is made from this liquid.

Kate Broderick: Then it's injected into the subject or the patient. And your own body is able to react and mount what we call an immune response against that part of the virus.

Stephen Hoge: I don't feel like we get to choose when an epidemic happens. We just get to decide how we're gonna respond. And what we've decided to do is try and use our platform to bring forward a safe and effective vaccine.

Former emergency room doctor, Stephen Hoge, is president of Moderna, a Boston area biotechnology company also working on a vaccine. We met Dr. Hoge shortly after the CDC recommended social distancing. Teaming up with the NIH, Moderna started human trials last week in Seattle, where the North American outbreak took hold. Forty-five healthy volunteers will receive injections over six weeks and be monitored for a year to see if the vaccine is safe. Moderna started work on the vaccine as soon as China posted the virus genetic sequence online.

Bill Whitaker: So how long did it take you to go from getting this genetic information to actually having a vaccine ready for human trial?Stephen Hoge: 25 days. It was released to the clinic within 42 days. Dr. Tony Fauci called it the-- I think the world indoor record. But it's definitely faster than we think anybody's-- done before.

Moderna's process pushes the envelope of biotechnology. Its scientists manipulate the genetic code to instruct cells what to do - in this case trigger the body's immune system to fight the new coronavirus.

Stephen Hoge: Once you realize that you can essentially put a software-like program into a cell the opportunities to address human disease are pretty broad.

Bill Whitaker: How did your relatively small biotech get to be the first one to go into human trials?

Stephen Hoge: Some of that has the advantage of the technology we're using. it allows us to move incredibly quickly-- when we have a pandemic situation like the one we're in.

Bill Whitaker: So you-- you have never brought a-- vaccine to market using this technology.

Stephen Hoge: No. We have not.

Bill Whitaker: Have not?

Stephen Hoge: We have not yet.

The National Institutes of Health is collaborating with Moderna to accelerate the development of a coronavirus vaccine. They hope to start a second phase of human trials in a few months.

Bill Whitaker: The whole world is sort of watching and waiting. So if you find that this works, when will people be able to start getting vaccines?

Stephen Hoge: Well, if we're able to show there's a clear benefit-- we're gonna need to be able to make sure that it's accessible to everybody who needs it. And so we've actually already started the investment to scale up supply into the millions of doses. But ultimately what we really need to focus on is generating the clinical data that shows that the vaccine, in fact, does have a benefit, that it's safe and effective.

Bill Whitaker: this is the purest form--

Kate Broderick: This is-- this is the purest form of the DNA.

Kate Broderick of Inovio told us technology is accelerating vaccine development, but it's no match for people's expectations.

Bill Whitaker: what is the realistic timeline for this vaccine being administered to the public?

Kate Broderick: We're hoping to have our vaccine tested in what we call a large, phase two trial by the end of the year, which would be potentially hundreds, if not thousands, of subjects being treated. But to have it rolled out to the public is likely to take longer than that.

Bill Whitaker: So the best case scenario is more than a year. Any way to speed up that process?

Kate Broderick: Really, I-- I have to say, we're going as absolutely fast as we possibly can.

With the number of people with the virus growing exponentially and deaths climbing inexorably that timeline just doesn't seem fast enough. With so much human suffering, hospitals in the U.S., Europe and Japan have given several hundred desperate patients the experimental antiviral drug, remdesivir, for what is called compassionate use. That's the drug being studied in clinical trial at the University of Nebraska Medical Center.

Dr. Angela Hewlett: We wanna make sure that, you know, we're not giving-- drugs to people that could have side effects.

Bill Whitaker: Now I know you don't know who's getting the drug and who's getting the placebo. But from what you've observed of the patients who are in the trial, what have you seen?

Dr. Angela Hewlett: So we have seen patients improve.

Bill Whitaker: You have?

Dr. Angela Hewlett: but it-- it's hard to tell if they would've just gotten better on their own, or if was due to the drug. And that's the reason that we really need to study this drug in this fashion.

Director of the CDC, Dr. Robert Redfield, told Congress this month we should know in a matter of weeks whether remdesivir is effective. But until a proven treatment and vaccine are available to fight this pandemic, doctors and researchers will keep working at a fevered pitch.

Bill Whitaker: Is this like a race to get to a vaccine?

Stephen Hoge: not really.

Bill Whitaker: How would you describe it?

Stephen Hoge: there's a lot of fear out there right now. And there is a competition. But it's not between the companies. It's between all of us and the virus. It's not us and them. It's us versus it. And the only way we're gonna beat the coronavirus is all working together. No one group, no one company can possibly expect to do this alone.

Produced by Marc Lieberman and Ali Rawaf. Edited by April Wilson. Broadcast associate, Emilio Almonte.

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In clinical trials and laboratories, the hunt is on to find vaccines and drugs to treat, prevent novel coronavirus - 60 Minutes - CBS News

COVID-19 Throws A Wrench Into Surrogacy (Along With Everything Else In The World) – Above the Law

(Image via Getty)

COVID-19 is affecting every facet of our lives, and the world of surrogacy is no exception. The news is changing so fast that anything written today will likely be out of date tomorrow. However, in the effort to provide helpful information, heres the latest.

Expect Delays.We are all being told to stay home and not leave unless its an absolute necessity. So it is no surprise that we are seeing delays and postponements for clinical and other providers. The European Society of Human Reproduction and Embryology (ESHRE) issued astatementon March 14.That date was a Saturday, so you know things are really drastic.

The statement from the European entity said: As a precautionary measure and in line with the position of other scientific societies in reproductive medicine we advise that all fertility patients considering or planning treatment, even if they do not meet the diagnostic criteria for Covid-19infection, should avoid becoming pregnant at this time. For those patients already having treatment, we suggest considering deferred pregnancy with oocyte or embryo freezing for later embryo transfer.

So halt everything for now.But thats Europe.

What about in the United States? I spoke with fertility specialist Dr. Althea OShaughnessy, on Monday, March 16, as to what she is seeing in the United States and with her practice. At that time (two days ago), she explained that things were generally still full speed ahead but subject to change. The next day, March 17, her clinic announced that all noninitiated frozen embryo transfers and intrauterine inseminations were cancelled or indefinitely postponed. Shortly after that announcement, the American Society for Reproductive Medicine (ASRM), the American counterpart to ESHRE, issued new guidance with the following recommendations.

OShaughnessy explained that if a patient was actively in a cycle - meaning that her body has been subject to the medical protocol to prepare for an egg retrieval, for example, and there was a risk of hyperstimulation if she did not go through with the retrieval - then even if the patient was showing active signs of illness, the clinic may go forward with the procedure for the safety of the patient. The clinic would, of course, take all precautions for its staff. Moreover, OShaughnessy clarified that the clinic was proceeding with IVF cycles for cancer patients needing to freeze eggs or embryos prior to gonadotoxic chemotherapy.

COVID-19, so far, isnt believed to be like the Zika virus, where there was a reason to fear birth defects for pregnant women who contracted the disease. But the evidence for that good news is scant so far, and at least one country has designated pregnant women as an at risk group.

Have A Plan AZ. Or At Least Through C.

Of course, in more urgent matters, numerous intended parents are awaiting the imminent birth of their children via surrogacy. And while everyone is concerned for the health of the surrogate and the child, there is also a basic problem of logistics. Many intended parents do not live locally to their surrogates, and some are in Europe or China, making travel especially difficult.

I spoke withCarey Flamer-Powell, the director of a surrogacy matching and support program in the United States. Flamer-Powell explained that while the current situation is stressful for many, her organization has always required a three-step plan for intended parents to be responsible for their children in case they are unable to make it to the birth. For Plan A, intended parents should be doing everything they can to be sure at least one of them can make it to the birth to care for their child from the first moment. She noted that one parent she worked with from China recently had to route through Thailand, go through a 14-day quarantine, and then was allowed to proceed to the United States. He missed his childs birth by two days, but was thankful to have made it fairly close behind.

For Plan B, all intended parents must have a local caregiver ready to take care of the child. That can be as simple as having a local friend or family member or a paid caregiver. Flamer-Powell explained that Plan C was that her organization would step in and provide care. (For an example of this happening, check out this podcast episode.) She has worked with other professionals in the field to form a network of people throughout the United States, and they are ready and willing to step in and provide care for a newborn if called to do so. That is one of those heartwarming moments where it is nice to see competitors coming together during difficult times, collaborating for the greater good.

Limiting In-Person Contact May Be Especially Significant.One provision of every basic surrogacy contract addresses who is permitted to be in the delivery room. Generally, the concern is only an issue when a C-section is necessary and the anesthesiologist limits persons present in the room. It may result in a difficult choice between the surrogates spouse (or other support person) or one of the intended parents being there to see their child come into the world. Now, that choice may become standard even if the birth isnt by C-section, or, worse, a surrogate may be on her own, without anyone aside from medically necessary persons present as hospitals work on evolving protocols to minimize risk. And, if intended parents, or support persons, meet certain risk criteria, they may not be permitted in the hospital at all!

Legal Problems Ahead. In almost every state, the law presumes that a woman giving birth is the legal parent of the child. A judicial process is used to correctly name the intended parents as the legal parents of the child, and to relieve the surrogate of any presumed responsibility. As courts close, these legal presumptions are likely to become a bigger problem. Temporary fixes will need to be utilized - such as delegations of power - and birth certificates may be issued late or may need to be amended.

In the meantime, some of the routine work of surrogacy, such as the legal contracts, is charging ahead and incorporating new COVID-19 clauses. These are predictable so far; basically that everyone agrees to follow doctors recommendations to minimize risk. And I suspect these will expand to requiring parties to also follow governmental edicts and recommendation.

Of course, the situation could look very different in a week. Or tomorrow. Heres to hoping it doesnt get that much worse, and that we see improvement soon. In the meantime, take all of this seriously. Listen to what the professionals are saying. And be safe. For you and your future children.

Ellen Trachman is the Managing Attorney ofTrachman Law Center, LLC, a Denver-based law firm specializing in assisted reproductive technology law, and co-host of the podcastI Want To Put A Baby In You. You can reach her atbabies@abovethelaw.com.

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COVID-19 Throws A Wrench Into Surrogacy (Along With Everything Else In The World) - Above the Law

Scientists are racing to model the next moves of a coronavirus that’s still hard to predict – Science Magazine

This model shows the most probable routes that the novel coronavirus will take tospread from the international airport in Beijing to airports around the world. Bubble size represents relative risk at each airport.

By Jon CohenFeb. 7, 2020 , 6:15 PM

Beyond China itself, Thailand is the country that most likely will have people who arrive at one of its airports with an infection by the novel coronavirus (2019-nCoV) that has sickened more than 30,000 people. So says the latest update of a global risk assessment model created by a team of researchers from the Humboldt University of Berlin and the Robert Koch Institute that relies on air travel data.

Next on the teams list is JapanOsakas international airport, interestingly, is more at risk than Tokyoswhich is followed by South Korea, Hong Kong, and then the United States. Russia likely has more infected people flying in than India, Germany (mainly the Frankfurt and Munich airports) is the most vulnerable country in Western Europe, and Ethiopia is the only sub-Saharan African country to break into the top 30 of virus-threated countries.

So, how seriously should this model, and the dozens of other computer simulations of the outbreak, be taken? Scientists studying the 2019-nCoV outbreak are getting plenty of data to groundtruth and tweak their models. As of yesterday, for example, the most confirmed cases outside of mainland China were in Japan (45), Singapore (28), Thailand (25), Hong Kong (24), and South Korea (23). That could be considered a partial success for the Berlin model, but it also reflects that this is a dynamic outbreak that upends assumptions at a blinding speed; for example, the airport in Wuhan, China, the outbreaks epicenter, was closed on 23 January, which radically altered airline exportation of the virus, and today there are 61 confirmed cases on a cruise ship off the coast of Japan.

This is not so much a tool for making quantitative predictions, says Dirk Brockmann, a physicist at Humboldt who leads the modeling team. Public health officials and policymakers have to develop an intuition because this virus is something unknown. Models can help you develop an intuition.

A flurry of models of the 2019-nCoV outbreak have been shared on websites, preprint servers, and in peer-reviewed journals, and many attempt to do far more than just sharpen hunches about where infected air travelers are going to land. If they have robust enough data, models can forecast the rate at which an outbreak will grow and help predict the impact of various interventions. When you start to include disease dynamics and population information, theres more information than just intuition, says Alessandro Vespignani, an infectious disease modeler at Northeastern University.

The centerpiece of many outbreak/infectious disease/pathogen models is the basic reproduction number, or Ro (pronounced R zero or R naught). Its essentially how many people each infected person can infect if the transmission of the virus is not hampered by quarantines, face masks, or other factors. Modelers also look at the incubation time, which is how long it takes for the virus to cause symptoms. The serial interval factors in the time between a person developing symptoms and a contact becoming ill. In this young outbreak, unknowns riddle every model. The current estimate for 2019-nCoVs incubation time has been hard to pin down with the U.S. Centers for Disease Control and Prevention suggesting theres a range of 2 to 14 days. There are many things that should be carefully weighted at this point, and thats why the modeling has difficulties, Vespignani says.

One of the first models to come outby a group at Imperial College London on its website on 17 Januarylooked at confirmed infections outside China to infer the number of infections that likely had occurred in Wuhan. At the time the group released that model, Wuhan had only reported that 41 illnesses were caused by the virus, and the model estimated that by 12 January, the infection had actually sickened 1723 people in the city. Those estimates, which were startling at the time, seem quaint now: As of 5 February, there were 27,619 confirmed cases, and a modeling study by the University of Hong Kongs Joseph Wu and colleagues that was published online by The Lancet on31 January estimated that Wuhan alone had 75,815 cases by 25 January.

Many of the early calculationsincluding the initial airport analysis done by Brockmanns team (which does daily updates)lost all meaning after Wuhan shut down public transportation. That was just over 2 weeks ago, which seems like 2 years ago now, Vespignani says.

One of the most vexing mysteries at the moment that can undermine modeling is whether people with 2019-nCoV who do not have symptoms can transmit an infection. Its possible that there are infected people who never become ill but still transmit. There also may be infected people who transmit before they develop symptoms. Most of the fate of the epidemic is in this element, Vespignani says.

The viral diagnostic tests being used to confirm cases now typically are only done on people seeking care because they are ill. One way to find asymptomatic or presymptomatic cases is to examine peoples blood for signs of an immune response to 2019-nCoV. To know the full extent of spread youd like to collect blood samples from contacts of infected people and do the same 2 weeks later and see if theyve developed antibodies to the virus, says Marion Koopmans, whose team at Erasmus Medical Center is racing to develop an antibody test for 2019-nCoV. That gives you a better estimate of spread without symptoms.

Models may also become sharper as researchers have a finer understanding of the epidemiology of infected cases, which means details about their location, health, age, and gender. Those data can help modelers make more reliable assumptions about factors like incubation time. To that end, computational epidemiologist Moritz Kraemer at the University of Oxford has spearheaded an unusual effort to compile a line list of confirmed cases by sifting through government reports, the medical literature, reliable media accounts, and social media. Line lists contain incredibly useful information that are not visible in aggregated case counts, Kraemer says. Unfortunately, line list data are rarely available during outbreaks and until now only routinely collected by governments that do not share them openly.

This line list, which has more than 15,000 cases on it now, documents everything thats public about infected individuals. His group has already used the data in a study that assesses the capacity of countries in Africa to detect and respond to cases; two of the five most vulnerable countries on the continent, Ethiopia and Nigeria, have what they call variable capacity to respond to the outbreak. A modeling study by a different group used the data to assess transmission dynamics, concluding that once a place has three cases, there is more than a 50% chance the virus can become established in the population.

On top of needing better data, models also suffer from how their forecasts are interpreted by journalists or the public. Robin Thompson, a mathematical epidemiologist at Oxford who has modeled the outbreak, contends many news stories have garbled descriptions of Ro, the basic reproduction number, and exaggerated the risk of spread. Its being misused in this outbreak, Thompson says.

Most estimates for 2019-nCoV calculate that Ro is between two and threethat an infected person will infect two or three others. But this is just an average. Some infected people, by chance, wont transmit the virus to anyone else. The real question from a population standpoint is what is the probability with an Ro of, say, 2.2, that there will be sustained transmission of the virus? With this new virus, Thompson calculates theres a 54.5% chance of sustained spread starting from a single infected person if nothing, for example a vaccine, prevents transmission.

Ro does not change during an outbreak: A virus has a certain, fixed contagiousness factormeasles, for example, more easily spreads between people than influenza. But even in the absence of a vaccine, human behavior and the environment itself can alter the likelihood of spread. Hospitals isolate infected people or they choose to stay home. A further decrease also often occurs as an outbreak matures and many people become immune because of previous exposure, reducing the number of susceptible hosts. Hand washing, wearing protective garb, and social distancing can also reduce transmission rates. A climactic shift, like winter becoming spring, may affect the ability of a respiratory virus to transmit through the air.

In the lingo of modelers, what matters most is not the unchanging basic reproduction number of Ro, but what they somewhat unimaginatively refer to as the reproduction number, or R, that factors in these other variables. R is constantly in flux. Heres an example of R, expressed as a percentage: Thompson calculates that if 50% of infected symptomatic people are isolated and 20% are asymptomatic, then the risk of sustained transmission is 24.2%.

The take home message from this R analysis is that countries other than China still have a good chance of containing 2019-nCoV. Early on in an outbreak, you can take advantage of the fact that theres this probability of the thing fading out, Thompson says. And if you can isolate the few infected people you have very quickly, then the probability of this fading out is much higher.

Ultimately, models are a science-based attempt to inform public health policy. Take travel restrictions. Wu says he doubts that restricting travel from Wuhan will have any impact on spread within China at this point. He points to calculations by an international team of scientists that the Wuhan travel restrictions, which those researchers described as the largest quarantine in human history, delayed spread to other cities in China by just 2.91 days. Keeping Wuhan locked down now would not make a difference for [epidemiological] curves for other cities in China now, Wu says. Now, social distancing there is essential.

Hong Kong, which has 24 confirmed cases to date, waited until today to close its own borders to people from mainland China. The public had asked the government to reduce the flow from the mainland, and the government had different reasons for not wanting to do that, Wu says. Public health is a priority, but the economy is also a major concern. If it cuts people flow, it can also cut the supply chain of necessary products to Hong Kong.

So the balance between public health and politics factor in to 2019-nCoVs spreadwhich means a refined understanding of Ro and R, incubation time, the serial interval, and other variables can only sharpen a models predictive powers to a point. As most every honest modeling paper cautions, There are limits to this analysis.

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Scientists are racing to model the next moves of a coronavirus that's still hard to predict - Science Magazine