She is what she eats: Keeping cows fit and healthy longer with the right feeding strategy – Farmers Review Africa

Home Feature She is what she eats: Keeping cows fit and healthy longer with the right feeding strategy

What goes for human beings, also goes for dairy cows: A healthy and individually tailored diet is one of the most important requirements for high performance and well-being. With GEAs automated feeding systems, the perfect recipe can be conveniently delivered to each animal group. Years of experience as well as the latest scientific findings advise systems for precision feeding. The success speaks for itself: Farmers are achieving significantly improved animal health with above-average herd performance. In addition, better feed quality and resource-friendly feed conversion go hand in hand with huge time and labor savings, as well as the ability to optimize feeding strategies in a targeted and result-oriented manner.

Measuring out fodder is surprisingly easy in the feed kitchen. Depending on the size of an operation and the number of animals needing to be fed, space-saving bunkers for basic feed types as well as containers for minerals are installed. The recipes selected feed types and desired quantities can be conveniently entered into the WIC System. Weighing and mixing take place automatically in the stationary mixer or directly in the feed wagon. And while the feed wagon provides the selected animal groups with individual, freshly prepared rations at predetermined times, current milking results can be checked against the feeding strategy. Precisely these valuable conclusions help dairy farmers achieve short- and long-term goals. Because results can be replicated, producers are able to continually optimize the feeding strategy.

Its clear that individual feed mixes designed to suit a cows nutritional needs will best support its performance. In conventional feeding systems, however, dividing animals into performance groups, means a corresponding increase in work hours. With GEAs automated feeding systems, it doesnt matter how many groups are desired, the only work required is filling the bunkers, which only takes about 30 minutes. Every animal group is provided with the optimal feed ration: cows at the beginning or the end of lactation, dry cows as well as youngstock and heifers receive exactly the rations they need for their current lactation phase, their calculated calving period, or their recommended weight gain.

Heifers are the cows of the future. The way they are fed improves not only their well-being, but has a direct influence on their lifelong productivity. To support growth in the best possible way, GEA has developed automated feeding systems, where even small batches can easily be mixed and distributed according to plan. The latest research shows that heifers that were fed according to a precise feeding plan grew faster. In addition, they calved significantly earlier than in the conventionally fed control group (22.2 compared to 24.6 months). Meanwhile, the costs for rations as well as feed and supplements were nearly identical in both groups. Thanks to the earlier age at first calving and the increased willingness to perform over the animals entire life cycle, an investment in the automated feeding system pays off. The additional time required for preparing and distributing smaller rations is taken on by the system.

Feeding that is efficient for the farmer also helps cows absorb nutrients better for their own energy balance. In a cows stomach, there are millions of active bacteria that support the digestion of plant fibers. Because microorganisms cannot adapt very well, they need a relatively stable environment to carry out their tasks. The ideal pH level for a good feed conversion is at 5.5 6. An efficient method to keep the pH level in the rumen as consistent as possible is to provide feed throughout the day. Another argument for frequent feeding is supplied by the cow herself: her tendency to sort against small particles in her feed contributes to an unbalanced diet, which in turn has a negative impact on the pH level in the rumen. Here, too, frequent feeding is a successful countermeasure, as it verifiably reduces variations in the pH value during the day.

The last in line only get the leftovers: this often applies when feed is conventionally distributed on the feeding table. Since the nutritional value of the ingredients begins to deteriorate as soon as feed is distributed, low ranking cows, who are initially denied access to the feeding table, can maintain neither their feed and nutrient intake nor milk production to the full extent. The common practice of pushing the feed forward may provide all cows with access to it, but cannot guarantee the uniform quality of the feed mix. When animals are fed more often, they distribute their feed intake more evenly throughout the day. At the same time, the movement profile of lower ranking cows reveals that when they get equal access to the feeding table, they are better fed with all the necessary nutrients. The otherwise labor-intensive processes of weighing, mixing and distributing can conveniently be carried out by the automated feeding system. All programmed tasks are taken care of on time, precisely according to plan.

Back to feed quality and the advantages of a feed kitchen: At conventionally feeding dairy farms, mixed feed rations are often exposed to the air for long periods, which accelerates the deterioration and decay of nutrients particularly during the summer months. In automated feeding systems, this process is slowed down by the storage in feed bunkers, because feed is only prepared and mixed during each day as needed. Aside from the order of feed components, a feed mixture can be optimized by the type of cut applied as well as single or multiple mixing. Best results are achieved when starting with dry and ending with wet ingredients. Thats why farmers using GEAs systems recommend beginning with dry fodder and grains, then adding concentrates, minerals and vitamins and finishing with silage, molasses and water. This is how the feed kitchen offers the best conditions, because its the quality of the mix that determines whether cows take in the right amount of nutrients for milk production, reproduction and good health.

A pioneering function in automated feeding consists of updated performance indicators supplied by process control and the software. To this end, daily procedures such as feed quantities distributed per group, mixing times or feed intake are recorded and referenced. The immediate evaluation and analysis in connection with information on milk performance of individual animal groups or heifers weight gain make it particularly easy for the farmers to make changes to feeding plans in real time and to improve feeding efficiency step by step. It makes no difference whether the farm feeds a full, partial or mixed ration in combination with grazing.

Latest research findings served fresh to the feeding table The proof is in the research: for cows well-being, health and vitality, freshly prepared feed should be distributed multiple times a day and as individually as possible. Feeding strategy, feeding frequency and feed mix are directly connected to animal stamina, milk yield and milk quality. The fact that efficient feeding and a successful feed strategy is not only good for cows, but is generally the decisive factor for the profitability of dairy farms, can not only be seen in improved herd performance, but is directly connected to sustainable feed implementation, savings in feed costs as well as improved reproduction. With significant labor savings, GEAs automated feeding systems offer every opportunity to test, analyze and reproduce promising feeding strategies at any time..

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She is what she eats: Keeping cows fit and healthy longer with the right feeding strategy - Farmers Review Africa

Marie Stopes International name change will put a focus on the future of reproductive choice, CEO says – The World

Marie Stopes Internationalis one of the largest organizations in the world providing women's health care and family planning services. Recently, they announced that starting Tuesday, they are changing their name to MSI Reproductive Choices.

That's because their namesake, Marie Stopes, was a birth control pioneer in early 1900s England, but was also a supporter of eugenics, a now-discredited movement to improve the human race through selective reproduction.

Stopes opposed interracial marriage and advocated for the sterilization of people considered unfit for parenthood.

MSI said the change was a clear signal that we neither adhere to nor condone Stopes' views, who was also a womens rights campaigner andfounded Britains first birth control clinicknown as The Mother's Clinic, in London, in 1921.

The modern organization was founded in 1976 when Dr. Tim Black saved the financially struggling Marie Stopes clinic from closure. The organization now operates more than 600 clinics around the world.

Simon Cooke is the chief executive officerof MSI Reproductive Choices and joins The World's host Marco Werman,from London, to talk about the name change and the future of MSI in 37 countries around the world.

Related:How the US presidential election could impact women's health

Simon Cooke: Marie Stopes International, which is the organization we've just transitioned the name away from, was founded in 1976, by Dr. Tim Black. And we took the name of Marie Stopes because Tim Black took over The Mother's Clinic [the original Marie Stopes clinic] which is in central London. So, there's actually no direct connection to Marie Stopes, apart from the fact that we took over that particular clinic, which was very well-known in the UK as the first birth control clinic in England. Marie Stopes is a person who was born in 1880. She was certainly a woman of her time, an acknowledged family planning pioneer, an extraordinary woman in many ways. But as you say, she did have extreme views on eugenics, as many people did at the time. And we felt that those views were not really compatible with MSI's values and principles today and hence the need for the change of name.

Related:Activists in Kenya challenge abortion ban in court

It is right, yeah. I mean, we originally had a resolution from our board of trustees back in November 2019 to change the name because this is not a new topic for us. And we had been discussing it for some time. Obviously, with Black Lives Matter and the discussions that came up around that within our organization, with many people hearing some of Marie Stopes' views for the first time, we felt it was entirely the right time to make that decision. And at the same time, we're launching a new 10-year strategy, which obviously allows us to reposition ourselves to explain a little bit more about what we do in the name and to really put a focus on the future rather than continue to focus on the past.

To some extent, it hasn't really affected us because most of our work is done overseas, and we're in 37 countries where those connections are not really understood or known. And our work is very much focused on alleviating poverty and gender empowerment and gender equality, so really trying to focus on those with the greatest unmet need for contraception or safe abortion services. So, those connections are not made. Increasingly, though, in the UK, some of the Marie Stopes connections have come up again and again in the last three or four years, particularly, and mainly inside our own organization, among our staff, that they felt increasingly uncomfortable with the association and felt that there was an appropriate time to to make that disassociation. And therefore, we're very happy to have done that. The Black Lives Matter movement, clearly for us, was another matter of internal discussion that allowed us to make that decision. And we feel it was entirely right.

Related:From Burkina to Zimbabwe, US aid cuts squeeze family planning

No, I don't think so. I mean, it's come up surprisingly little. I mean, most people who fund us and who work with us understand that we were founded in 1976, and that we took over The Mother's Clinic, and that's the reason why we took the name. But beyond that, that the association really hasn't become an issue until quite recently and actually most notably in the US, because we have more of a presence in the US now as a fundraising organization to support our mission overseas. That was a problem for us as we tried to reach out to potential donors in the US who had never heard of it before. But at that point, I think the discussion became more pivotal and we felt that we needed to do something, to take action.

Our vision for 2030 is that no abortion will be unsafe and every individual will have access to contraception. And today, as I said, we operate in 37 countries. We provide 28,000 services a day. But there is a huge amount to be done because there are 230 million women and girls worldwide who have no access at all to contraception but want it. That is a need that needs to be met, we know how to do this and we know what it costs. We are going to use the new strategy really to define how to close that gap and how to make sure that every woman and every girl who wants access to contraception will be able to get it. The strategy is really to focus on choice, which is in the name reproductive choices and also to broaden services beyond just safe abortion and contraception to a range of services to support women and girls from their first period through menopause.

This interview has been edited and condensed for clarity. The Associated Press contributed to this report.

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Marie Stopes International name change will put a focus on the future of reproductive choice, CEO says - The World

A 3D atlas of the dynamic and regional variation of pancreatic innervation in diabetes – Science Advances

Understanding the detailed anatomy of the endocrine pancreas, its innervation, and the remodeling that occurs in diabetes can provide new insights into metabolic disease. Using tissue clearing and whole-organ imaging, we identified the 3D associations between islets and innervation. This technique provided detailed quantification of and cell volumes and pancreatic nerve fibers, their distribution and heterogeneity in healthy tissue, canonical mouse models of diabetes, and samples from normal and diabetic human pancreata. Innervation was highly enriched in the mouse endocrine pancreas, with regional differences. Islet nerve density was increased in nonobese diabetic mice, in mice treated with streptozotocin, and in pancreata of human donors with type 2 diabetes. Nerve contacts with cells were preserved in diabetic mice and humans. In summary, our whole-organ assessment allows comprehensive examination of islet characteristics and their innervation and reveals dynamic regulation of islet innervation in diabetes.

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A 3D atlas of the dynamic and regional variation of pancreatic innervation in diabetes - Science Advances

The Many Abuses at the Irwin County Detention Center in Georgia – The Nation

Dawn Wooten, left, a former nurse at Irwin County Detention Center in Ocilla, Georgia, speaks at a news conference in Atlanta protesting conditions at the facility. (Jeff Amy / AP Photo)

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This place is hell. My experience was darkness, dirtiness, muddiness. The floorsdirty. The wallsdirty. Everything was dirty.Ad Policy

In 2019, Jaromy Floriano Navarro was sent to the Irwin County Detention Center in Georgia, where she was held for nearly a year before being deported to Mexico in September. While at Irwin, she had a distressing experience with a medical provider who treated detainees at the facility. I met [gynecologist] Dr. [Mahendra] Amin in March. He said I had a cyst. He told me about the process to get my cyst removed. I was going to have three little dots on my belly, and it would take 20 minutes. One hole by my belly, one by my womb, one by my vagina, she said. The nurse who was taking me to the hospital told me that I was going to have my womb removed. I was like, What? No, thats not right. I am going to have my cyst removed.

Upon arriving at the hospital for the procedure, Floriano Navarro learned that she was positive for Covid-19 antibodies and her procedure would be delayed. When she returned to Irwin, she said, she was put in isolation. A few days later, she was told that she could now have her surgery. She said, I refused, and this made them mad. They were so mad. [They said,] You stay here. You get the surgery. Weve already paid for it.

Floriano Navarro began talking to other women housed at Irwin and learned that others had had similar experiences. Then on September 14 of this year, whistleblower Dawn Wooten went public with the claim that Amin had been performing an unusually large number of hysterectomies on women held at the center. You could quote me as the one that got away, Floriano Navarro said. Wooten, who was a licensed practical nurse at the facility, reported that several detained women told her they were given hysterectomies and did not understand why. In a complaint, she alleged that once the information about this practice spread, many detainees became wary of seeing doctors at the facility at all and other staffers began to wonder how widespread the practice was. Weve questioned among ourselves like goodness hes taking everybodys stuff out. Thats his specialty, hes the uterus collector, Wooten said in her complaint. I know thats uglyis he collecting these things or something. Everybody he sees, hes taking all their uteruses out or hes taken their tubes out.Related Article

The complaint, filed with the Office of the Inspector General of the Department of Homeland Security (DHS) by human rights groups, including Project South, quoted an Irwin detainee who had spoken with other detained immigrants who had received hysterectomies, saying that they reacted confused when explaining why they had one done. The woman told Project South that it was as though they were trying to tell themselves its going to be OK. She added, When I met all these women who had had surgeries, I thought this was like an experimental concentration camp. It was like theyre experimenting with our bodies.

Since the complaint went public, multiple women have come forward with accounts of similar experiences at Irwin. One former detainee, Pauline Binam, said she had her fallopian tubes removed without her consent. Mileidy Cardentey Fernandez told The Guardian that she was told she would undergo an operation to treat ovarian cysts but she remained unsure of what procedure she actually underwent. Most recently, the Los Angeles Times reported on the accounts of 19 mostly Black and Latinx women who underwent or were pressured to undergo overly aggressive or medically unnecessary surgeries without their consent while detained at Irwin, according to a report by nine board-certified ob-gyns and two nursing experts who reviewed thousands of pages of those womens medical records. Wendy Dowe, speaking to the Los Angeles Times, said she told Amin, Ive got the right to know whats going on with me. After surgery, she was surprised to see bandages on her stomach. She wrote to his medical office, asking, What type of surgery did I have?

Amin has seen at least 60 women detained at Irwin, according to a lawyer investigating the alleged wrongdoing, and is now under investigation by the DHSs inspector general. But the problems at Irwin are hardly limited to the alleged sterilizations. The women interviewed by Project South reported horrifying conditions at the detention center as well as widespread medical neglect. In the interviews, we found evidence of sexual abuse, inadequate medical care, lack of prenatal care for pregnant women, a lack of clean drinking water, and rampant use of solitary confinement at the facility, said Azadeh Shahshahani, Project Souths legal and advocacy director. Detained immigrants who have spoken out about the conditions have faced retaliation. A Southern Poverty Law Center report noted that an Irwin detainee was placed in solitary confinement for three days for helping another complete a grievance form.Current Issue

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Wooten and several of the immigrants also claimed that the facility failed to follow best practices to prevent the spread of the coronavirus. In the complaint, Wooten stated that Dr. Howard McMahan, the medical director at Irwin, pleaded with warden David Paulk in March to halt all transfers of individuals in and out the facility after it recorded its first Covid-19 case. Yet McMahans pleas went unheeded: People with Covid have been entering the facility, which has also transferred immigrants out who were Covid-positive or had been tested but had not yet received their results. Wooten and various people detained at Irwin have reported that entire dorm units are placed under quarantine for 14 days after one individual is suspected of having or is confirmed to have Covid. The staffers mix new transfers with people who are under quarantine, resulting in greater vulnerability and risk. Representative Raul Ruiz, a California Democrat and an emergency physician, toured the center with other legislators after the allegations became public and said he saw, among other horrors, black mold in the shower stalls, which can cause or exacerbate serious pulmonary diseases.

The Irwin County Detention Center is run by LaSalle Corrections, a private corporation contracted by Immigration and Customs Enforcement. LaSalle operates seven immigration detention facilities in four states; Irwin, which houses about 800 people, has long been known for its unsafe conditions. In 2017, ICEs own review of the center found that certain areas were unsanitary and that floors and patient examination tables were dirty. LaSalle receives $60 a day from the federal government for each immigrant it houses, a sum intended to cover food, shelter, and medical care, according to a report by the Southern Poverty Law Center.

In response to the recent revelations, Project South and other local groupsincluding Georgia Detention Watch, the Georgia Latino Alliance for Human Rights, and the South Georgia Immigrant Support Networkare gathering signatures for a petition to close the facility and to seek redress for those harmed inside it. Meanwhile, the US House of Representatives has passed a resolution condemning the medical abuse and calling on the DHS to pause the deportation of people who experienced any medical procedures at Irwin and to hold the individuals involved in the procedures accountable.

The United States has a long history of reproductive violence against people who have been incarcerated or institutionalized or are otherwise seen as unfit to have children. In 1899, Harry C. Sharp, a physician at the Indiana Reformatory in Jeffersonville pioneered a program to sterilize incarcerated men. At that point in Indianas history, a number of social upheavalsincluding industrialization, urbanization, and a fear that people of color and poor white Kentuckians were encroaching on homogeneous communitiesworried the states middle and upper classes. His solution was to sterilize those considered dangerous, particularly those with a mental or physical illness. In 1907, Indiana passed the countrys first sterilization law, intended to prevent [the] procreation of confirmed criminals, idiots, imbeciles, and rapists. Though the law was struck down as unconstitutional in 1921, the state government estimated that approximately 2,500 people were sterilized through 1974, before the practice ended.

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These sterilizations of incarcerated people were only the beginning of many similar efforts to sterilize members of other groups, including people of color and people with disabilities, as a public health intervention. From 1919 to 1952, California sterilized approximately 20,000 institutionalized people because they were deemed unfit or defective. From 1929 to 1974, at least 7,500 people were sterilized in North Carolina, most of them without their consent, because the state Eugenics Board claimed they were unfit to reproduce. Many of them were poor Black or Indigenous women, though records show that children as young as 10 were sterilized. Nor are these abuses confined to decades past. In 2013, Reveal reported that from 2006 to 2010, at least 148 inmates in two California prisons were sterilized without proper state approvals or oversight, and there may be 100 more such incidents dating back to the late 1990s.

Knowing this long history of state-sanctioned eugenics policies is the first step in understanding the significance of the allegations by Wooten and the women detained at Irwin. As Dorothy Roberts, a professor of law and sociology at the University of Pennsylvania, explains in her seminal text Killing the Black Body: Race, Reproduction, and the Meaning of Liberty, the idea of population control as a social good is part of the fabric of US public health policy. Roberts argues that the American project of eugenics is rooted in the enslavement of African people and the complete denial of reproductive control. For Amari Sutton, an organizer with Project South, the abuses alleged at Irwin must be understood as the result of fascist state control and abuse of Black and brown bodies [and] the historical capitalist interest in incarceration and detainment that mirrors chattel slavery.

Representatives Rashida Tlaib, Alexandria Ocasio-Cortez, Ayanna Pressley, and Ilhan Omar are calling on international agencies to conduct investigations. Holding the Department of Homeland Security accountable for its long history of abuses is a human rights, reproductive justice, and public health imperativeone that has been put on the backburner at the expense and detriment of our immigrant neighbors, Tlaib said in a statement.

Like prisons, immigration detention centers are often isolated spaces, hard to reach and to monitor by design. These activists and detainees are taking great risks to expose what they know. Speaking to The Nation from Mexico in October, Floriano Navarro was distraught. I wish I was back home in South Carolina with my daughters, she said. Its like I cant breathe. The mental abuse and the depression I go through is so hard. When Im alone and I drift into my thoughts, I think about how it felt to be there. I want you to write about the depression. Its so hard.

She added, When you are inside there, its like you have no control of your life, its like they can do whatever they want to you.

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The Many Abuses at the Irwin County Detention Center in Georgia - The Nation

The coronavirus can survive on skin for this many hours, study suggests – Fox News

New research out of Japan suggests the novel coronavirus can live on human skin for up to ninehours.

In a study published in the journal Clinical Infectious Diseaseson Oct. 3, researchersfrom the Kyoto Prefectural University of Medicinefound that SARS-CoV-2outlived the influenza A virus (IAV) on human skin, which remained viable for about twohours.

New research out of Japan suggests the novel coronavirus can live on human skin for nine hours. (iStock)

The researchers generated a model that allows the safe reproduction of clinical studies on the application of pathogens to human skin and elucidated the stability of SARS-CoV-2 on the human skin, they wrote. The models were created from samples of human skin taken from autopsies, per Live Science.

CORONAVIRUS OUTBREAK AT NORTH CAROLINA HAIR SALON TIED TO AT LEAST 1 DEATH

Using the model, the researchers found the survival of SARS-Cov-2 was significantly longer compared to IAV, with 9.04 hours and 1.82 hours, respectively.

When both viruses were subsequently mixed with mucus to imitate a cough or sneeze, the novel coronavirus lasted about 11 hours, the researchers found.

OKLAHOMA CORONAVIRUS HOSPITALIZATIONS HIT RECORD HIGH FOR STATE

Thankfully, however, both SARS-CoV-2 and the influenza A virus were completely inactivated within 15 [seconds] by ethanol treatment, or hand sanitizer containing 80% ethanol, they said.

The 9-[hour] survival of SARS-CoV-2 on human skin may increase the risk of contact transmission in comparison with IAV, thus accelerating the pandemic. Proper hand hygiene is important to prevent the spread of SARS-CoV-2 infection, they concluded.

EMERGENCY COVID-19 VACCINE APPROVAL TO REQUIRE 2 MONTHS OF FOLLOW-UP DATA, FDA SAYS

The study had at least one limitation, however. The researchers in their review did not consider the viral load needed to cause a COVID-19 infection from contact with contaminated skin, Live Science noted.

The research comes after a separate study conducted early on in the pandemic, in March, found that the novel virus can live on surfaces such as plastic and stainless steel for up to three days.

CLICK HERE FOR COMPLETE CORONAVIRUS COVERAGE

Thatresearch, published in the medRxiv depository, noted that the virus can remain on copper surfaces for four hours and carboard for up to 24 hours. The research also found it could stay on stainless steel and plastic for anywhere between two and three days.

Fox News Chris Ciaccia contributed to this report.

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The coronavirus can survive on skin for this many hours, study suggests - Fox News

Letters to the Editor: Pray Roe v. Wade is history – Auburn Villager

Don Eddins, in his article, is uncertain as to the legal status of the Roe v Wade decision allowing abortion on demand, and only during the first trimester, since Trump has nominated Judge Amy Coney Barrett as a replacement for Judge Ginsberg on the Supreme Court. Judge Barrett has previously said that the 1973 Court decision was not based on the Constitution but on a "right to privacy" that liberal justices invented. There is no reference to "privacy" in the Constitution.

If a woman can kill her unborn child in "privacy," why can't she kill her born children in "privacy?" Or her husband or grandmother? The Declaration of Independence guarantees "life, liberty, and pursuit of happiness;" but if someone is denied life, they will never experience liberty or pursuit of happiness.

These questions must be answered if one thinks the Roe v. Wade decision was correct and whether it can be invalidated by another succeeding Court:

(1) Is the thing aborted human life? Will it be something other than human life at birth? What it will become at birth, it already is; another human person. Calling it by terms that describe its development stages does not make it non-human at any one point and human at another.

(2) When did it become a right for anyone to kill another human being? Why is that decision only the woman's right and not also the father's? The child could only come about because of the two different genders engaging in sex. Roe v. Wade gives the father no rights in this abortion decision, only the mother.

(3) Have other Supreme Court decisions been invalided later? Why is Roe v. Wade untouchable? Many like Hillary Clinton think that a mother's abortion decision is almost "sacred." The Dredd Scott decision allowing slavery was overturned along with hundreds of State laws that allowed slavery and the relegation of Blacks to a second-class citizenship. It was also the law of the land for some time.

(3) Eddins says: "Abortion is a strange issue in that no one is really for abortion. Some just believe women cannot completely have reproductive freedom without a right to abortion." Is that true? Reproductive rights are exercised when a woman chooses to engage in sex. Nature and science have provided many means to prevent reproduction. If she becomes pregnant from that prior decision, should society allow her to correct it by killing the conceived child? Would it be acceptable if some people want to commit serious crimes because they limit their "freedoms," so everyone else, who think these crimes are immoral, should just go along with it and accept the consequences?

In the 2000 Stenberg v. Carhart case concerning whether a State could prohibit "partial-birth" abortion, where the child is partially removed from the woman's womb, then its brains are vacuumed out or crushed, Judge Ginsberg mocked what she called the "emotional uproar" the procedure caused. What a great humanitarian jurist; may she rest in peace with the 50 million aborted children whose deaths she was unconcerned about.

Let's all hope and pray that Roe v. Wade is history, a terrible holocaust of human life.

This November, vote your values. Many people focus on the personalities running for president, but much more is at stake than tweets or hurt feelings. Whoever wins the presidency will likely be gone in four years, but the laws passed, judges installed, and policies implemented could have lasting effects on our country. Here are some considerations.

An unborn child can experience pain by 22 weeks of gestation or earlier. Doug Jones and Joe Biden support abortion through nine months of pregnancy. There are documented cases where a child who survives attempted abortion is left to die without medical care. Democrats in Congress refused to support a bill to protect these children. If you believe that submitting an unborn child to the pain of late term abortion is cruel, that every child who is born has a constitutional right to life, that taxpayers should not be forced to pay for abortions, vote for Trump and Tuberville.

Under the deceptively named Equality Act (EA) passed by House Democrats, boys, who are generally stronger than girls, can compete in girls sports, win scholarships intended for women and violate womens privacy by using their locker rooms and bathrooms. Under EA, people suffering from gender dysphoria (transgender) must be provided dangerous hormones and doctors must, against their best judgment, remove healthy organs in so-called gender affirmation surgeries instead of addressing the underlying psychological disorder. No procedure having a suicide rate post-surgery 19 times the national average can be therapeutic. Parents of minor children often have no say.

The EA eliminates religious freedom protections for individuals and businesses. Under EA, Christian adoption agencies would be forced to place children in same-sex households. Studies show that children raised by a mother and a father have the best chance of success in life. The reverse is true of same-sex households.

If you believe that children should not be denied the chance to ever experience the love of both a mother and a father, that adoption agencies should act in a childs best interests, that womens sports should be reserved for women, that compassion means protecting people from self-harm, and that you should not be forced to violate your faith in your workplace, dont vote for Democrats.

Prominent Democrats express anti-Semitic sentiments without censure and associate with avowed anti-Semites. Where poor children attend failing schools, parents should have the option of choosing an alternative school. This especially affects minority communities. Biden opposes charter schools and school choice. Trump calls school choice a civil right. If anti-Semitism should not be tolerated, if you support school choice, vote Republican.

Republicans believe judges should not legislate and that the Constitution and laws should be interpreted based on the meaning of the text at the time they were written.

The differences between the two parties have never been starker. Religious liberty, parental rights, childrens rights, school choice, our Constitution and much more are on the ballot this November. If these values are important to you, your vote is important.

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Letters to the Editor: Pray Roe v. Wade is history - Auburn Villager

Social Justice Groups Call for Action Following Reports of Gynecological Procedures on ICE Detainees in Georgia – YubaNet

WASHINGTON, October 2, 2020 Weeks after nurse Dawn Wooten came forward with allegations of forced and coerced hysterectomies performed on immigrant women at the Irwin County Detention Center (ICDC), Planned Parenthood Federation of America and leading social justice organizations based in Georgia are reiterating the need for immediate action to end these atrocities. Recognizing the long history of similar abuse in the U.S., Representative Pramila Jayapal introduced a resolution, HR 1153, that condemns unwanted and unnecessary medical procedures without the full, informed consent of individuals, and recognizes that everyone deserves to control their own reproductive choices and make informed choices about their bodies. Additionally, the resolution further states that accountability, oversight and transparency is necessary to protect people in the custody of U.S. Immigration and Customs Enforcement. With 225 co-sponsors in the House of Representatives, todays House passage moves this important resolution one step closer to accountability, oversight, and transparency on this devastating issue.

According to a new report from the New York Times, concerns from women detained at Irwin emerged long before Ms. Wooten came forward. Action cannot wait. SisterSong, Project South, Planned Parenthood Southeast, and other leading reproductive justice and immigrant rights organizations have announced specific demands of state and federal politicians and health care regulators to address the reports, which continued to go unanswered.

The report from Ms. Wooten, who is being represented by lawyers from Project South, is not isolated, but part of a long history of forced sterilization and state violence that targets Black and Latino people. This latest assault is one more example of the horrific abuse, medical neglect, and human rights violations that immigrant detainees have faced under this administration.

Statement from Alexis McGill Johnson, president and CEO, Planned Parenthood Federation of America:

Forced sterilization is a tool of white supremacy used to control and dehumanize Black, Latino, AAPI, and Indigenous people and we know that there is no reproductive freedom without justice for immigrants. These horrifying reports are a reminder that the threats to bodily autonomy, particularly for people of color, have been widespread and too often ignored. This is sadly nothing new. Planned Parenthood is proud to stand with SisterSong, Project South, Dawn Wooten, and the reproductive and immigrant justice leaders on the ground who are leading this movement for change. Were honored to follow the lead of our partners in this fight and work with them in support of the accountability they are seeking from state and federal agencies.

Statement from Monica Simpson, executive director, SisterSong:

Recent reports of forced hysterectomies on ICE detainees at the Irwin Detention Center, privately owned and operated by LaSalle Corrections, have sent shockwaves that have been felt so deeply in Georgia and beyond. As Reproductive Justice leaders and advocates committed to securing our human right to bodily autonomy, we are horrified and angry. This brazen attack on incarcerated Black and Brown bodies is part of a long history of policies and programs inflicting violence and harm on migrants and immigrants seeking refuge, safety and opportunity in this country. Forced gynecological procedures and the calculated sterilization of those incarcerated by ICE are yet another attempt to control who has children and who can make decisions about their reproduction. We know and have always known what we need and are committed to defending our bodies, our families and our human rights.

Statement from Azadeh Shahshahani, Legal & Advocacy Director, Project South:

We have documented conditions at Irwin for many years. The treatment of immigrants at this prison has always been horrid. These new shocking revelations further highlight the extent of the egregious abuses at the facility. The fact that Black and Brown immigrant women are held in an extremely vulnerable position at this prison where they have no control over their bodies and no say about what is done to them is sickening. Irwin should be shut down immediately and people should be freed. The United States Government, as well as the private prison corporation running this prison, should be held accountable.

Statement from Dr. Georgina Amaral, Physician at Planned Parenthood Southeast

As a reproductive health care provider, I was sickened to hear about the inhumane treatment of the detainees at Irwin. It is our job as physicians to respect the dignity and humanity of every patient no matter who they are or where they came from. Bodily autonomy doesnt end at the gates of a detention center. Coercing or forcing patients to undergo medical procedures goes against the hippocratic oath and everything we have committed our lives to as physicians. It is unconscionable to think that a doctor would perform hysterectomies without consent. It is unethical, if not outright criminal, and this physician must be held accountable. We demand the Georgia Medical Board to investigate this doctor and anyone else involved, and revoke their licenses. We also demand that the Department of Homeland Security take action to close down the Irwin County Detention Center and its operator, LaSalle Southwest Corrections. I also urge my fellow medical professionals to stand up and speak out against this atrocity boldly and without hesitation.

You can listen to audio from a September 17, 2020 press call HERE.

Planned Parenthood is the nations leading provider and advocate of high-quality, affordable health care for women, men, and young people, as well as the nations largest provider of sex education. With more than 600 health centers across the country, Planned Parenthood organizations serve all patients with care and compassion, with respect and without judgment. Through health centers, programs in schools and communities, and online resources, Planned Parenthood is a trusted source of reliable health information that allows people to make informed health decisions. We do all this because we care passionately about helping people lead healthier lives.

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Social Justice Groups Call for Action Following Reports of Gynecological Procedures on ICE Detainees in Georgia - YubaNet

Scientists help reboot 50 years of plant advice to solve one of nature’s biggest challenges – Newswise

Newswise Scientists from the University of Portsmouth and Royal Botanic Gardens, Kew, have come up with a formula to help plant breeders and farmers around the world grow crops in a more sustainable way.

The new checklist, which has just been published in theBotanical Journal of the Linnean Society, will guide plant breeders to better understand the species they are trying to improve. It will also help them find ways to increase growth and yield of crops using wild plant species from which they were once domesticated.

There is an urgent and critical need for changes in farming techniques due to the growing challenges of global warming faced by crop producers. Plants that were selected and bred to suit certain climates, now need more help from the humans who are damaging the environment in which they grow.

Study author Dr Rocio Perez-Barrales, Senior Lecturer in the School of Biological Science at the University of Portsmouth said: "When the human race first domesticated crops, the climate and environment were completely different - what we are seeing in the last 50 years is a rapid change in climate. The world is now frequently facing catastrophic climate events like droughts and in the UK we are now seeing some crops being harvested up to a month earlier than they used to be.

"When plants were domesticated, they were artificially selected for a specific desirable trait. Artificial selection and farming have led to quality improvements in foods such as meat, milk, and fruit. However, over hundreds of years, there has been a negative impact to this process - a reduction in plant genetic diversity.

"Scientists believe genetic diversity is important for plants to cope with a change in environment. This leads to a choice of using an artificial process such as the use of pesticides, to protect crops against pests. An alternative for plant breeders is to use wild crop relatives and use the natural genetic variation in those species that protects them against the natural enemies.

"Climate change is altering the way crops behave. Crops have lost so much genetic diversity they are less able to adapt and respond to climate change. Scientists are now looking at wild crop relatives to see what traits can be improved to make crops better adapted to the current environmental challenges."

The researchers re-visited guidelines set out 50 years ago that have since become outdated. They used this classification as a basis to deliver a new method of improving crops, without destroying the very few natural environments left in the world to grow food.

Dr Perez-Barrales explained: "Some crops have just a few closely related species, whilst others might have a hundred or so. For example, linseed has more than 150 related species, and the challenge is how do we select the relevant traits and from what wild relatives? In answering this question, we realised that we needed to learn more from the biology of the species, which can only be done by using modern classification developed using the latest science. The classification developed in the early 1970's needed to be updated, and in effect rebooted, to integrate this modern information."

This new toolset for crop breeders relies on identifying which wild crop relative needs to be explored in order to improve the crops. Dr Perez-Barrales said: "There may be a demand to grow linseed, for example, in countries at different latitudes. Linseed (Linum usitatissimum) was domesticated in the Middle East 10,000 years ago, and we can grow it in England because it naturally captured genes from pale blue flax, Linum bienne, allowing the crop to grow in northern and colder environments. My research looks at the natural variation in flowering of wild Linum species to see if we can use it to improve linseed. That way the right genes can be selected and introduced into the crop, something that plant breeders do regularly. These new guidelines will help plant breeders become more sustainable and efficient. We believe it is the future of farming."

This paper recommends guidelines for plant breeders to select the one right species to improve the crops. The guidelines include:

2. To understand if there is genetic compatibility between species. This includes understanding variation in chromosome numbers. For two plant species to successfully cross, they need to have the same number of chromosomes. As with humans, if the number of chromosomes don't match there will be problems in reproduction. However, plants can have very different chromosome numbers, ranging from 14 to more than 100. It is important to understand chromosome variation so we can understand their compatibility.

3. To gather all the information of the pollination biology, reproduction and the mechanisms to avoid inbreeding. Plants can prevent self-pollination and inbreeding, so the pollen of a flower does not fertilise the ovules from the same flower. Just like in animals, inbreeding can cause genetic diseases. But the mechanisms that avoid selfing can create barriers between the crop and the wild relative, making it difficult to create new hybrids that could be tested to validate the newly improved crop

Dr Juan Viruel from Kew Garden said: "In this study we advise plant breeders to use phylogenetic distance metrics, cytogenetic compatibility data (for example, chromosome number and ploidy) and information about the breeding system to shortlist wild species for plant breeding programmes". With this information we can better select the wild species to improve our crops. It is an invaluable checklist for plant breeders and will help production of crops in a more sustainable way."

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Scientists help reboot 50 years of plant advice to solve one of nature's biggest challenges - Newswise

West Virginias reproductive factor is below one – WVNS-TV

Gov. Justice and state officials provide an update for media on COVID-19 preparedness and response plans. For more information about COVID-19 prevention and more, call the States toll-free hotline at 1-800-887-4304 or visit Coronavirus.wv.gov.

Gov. Justice paid his respects to those who passed away from COVID-19 over the weekend. He asked people to be thankful for the years of service these West Virginians gave to their families.

The Rt (reproduction factor) in West Virginia has fallen below one to 0.98. That makes the state 15th best in the country.

The West Virginia Department of Education is reporting outbreaks at 17 schools across the state. The list is available on the WVDE website.

Free testing is ramping up across the state. The goal is to get daily testing up to 10,000. The minimum target number is 7,000. Testing is being done at sites across the state.

Additional free testing is being done in Kanawha County. On Monday, Tuesday and Wednesday there will be a site set up at George Washington High School. It will be held from 3 p.m. to 7 p.m. The Governor stated they will increase testing in Barbour County as well. The announcement of when and where will be coming.

The COVID-19 pandemic has led to modernization of the contact tracing system used by the Department of Health and Human Resources. The change was recently completed at all health departments. The surveillance system allows the DHHR to an additional 150 contact tracers. The DHHR is also working to improve the online dashboard.

The National Guard is working on sanitization missions. They are also working to finish adding WiFi hot spots for the Kids Connection Initiative. They expect to finish those by Wednesday.

Maj. Gen. James Hoyer mentioned recent statistics showing the number of suicides among the U.S. military is up 20-percent since the pandemic began. A crisis hotline has been established for National Guard personnel. Maj. Gen. Hoyer stated West Virginians should be watchful for their neighbors mental wellbeing.

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West Virginias reproductive factor is below one - WVNS-TV

Dalit Feminist Voices on Reproductive Rights and Reproductive Justice – Economic and Political Weekly

Transnational commercial surrogacy and the outsourcing of reproductive labour to women of the global South is arguably the most controversial practice in an expanding market in body parts and reproductive labour. The central role of India in this market represents a particularly challenging example, given the historical symbiosis between reproductive policies and population control in the country. For roughly a decade, India was a hub for commercial surrogacy and biocrossings, facilitated through the global assemblages of a liberalised capitalist economy (Bharadwaj 2008). Within this transnational fertility circuit, bodies of underprivileged Indian women, formerly seen as waste and their reproduction as something to be controlled by the post-independence Indian state and policymakers in the first world, were transformed into sites of profit generation within the reproductive industry of the neo-liberal Indian state (Rao 2010).

While previous research on surrogacy has addressed the stratified reproduction (Colen 1995) of Indian women in terms of class and economic status (Pande 2014; Rudappa 2015; Vora 2015; Deomampo 2016), the question of caste has received little attention (Madge 2015). Responding to the lack of research on assisted reproductive technologies (ARTs) and caste, the aim of this article is to explore the significance of this intersection toARTsin general and commercial surrogacy and egg donation in particular. We draw on in-depth interviews with Dalit feminists whose perspectives onARTsare uncharted.1Our analysis explicates the need to connect these issues with broader questions of social justice that we theorise through the framework ofreproductive justice. This understanding challenges dominant articulations ofARTscentred onreproductive rights.

Trends and Transitions in Surrogacy in India

A world-leading destination for medical tourism (Pande 2011; Deomampo 2016), surrogacy was legalised in India in 2002 and benefited from the active promotion by the Indian government (Rudrappa 2015; Deompampo 2016). As Amrita Pande (2014: 13) notes, [c]linics in India (...), not only operate without state interference but often benefit from explicit state support for clinics catering to medical and reproductive travelers. In 2012, a study conducted by the Confederation of Indian Industry (CII) estimated the fertility industry to $2 billion, with 600 clinics registered with the government, and another 400 under the official radar (Bhatia 2012). Nearly 10,000 foreign clients, of which 30% were single parents or identified as queer, travelled to India for reproductive procedures during that year (Rudrappa 2015: 39). Low costs, the availability of highly qualified English-speaking medical doctors, women willing to work as surrogates, and the lack of legal regulation surrounding surrogacy arrangements are factors that contributed to Indias flourishing fertility industry.

In 2005, the National Guidelines for the Accreditation, Supervision and Regulation ofARTClinics in India,developed by the Indian Council of Medical Research (ICMR) and the Ministry of Health and Family Welfare (MoHFW), were published (ICMR2005). However, through cases such asBaby Manji Yamada v Union of India(2008) and the Jan Balaz case in 2008, insufficient guidelines regarding citizenship of children born through surrogacy or parentage were brought to public attention (Saravanan 2018). Responding to the growing pressure on the Indian government from stakeholders within theARTindustry to provide a legal framework, theICMRand theMoHFWoutlined the Draft Assisted Reproductive Technologies (Regulation) Bill and Rules in 2008, which was revised in 2010 and 2013. Both the 2008 and 2010 versions of the draft were criticised for harbouring a bias towards the private sector and for promoting the interests of the industry, while failing to address the vulnerability of surrogatemothers (Sama 2012). The 2013 draft restricted the issuing of surrogacy visas to married couples, thus excluding single and gay parents. As a consequence, parts of the business moved to Nepal. However, since Nepal banned its female citizens from being hired as surrogates, but permitted foreign women, Indian and Bangladeshi women were taken to Nepal. A number of highly mediatised cases contributed to the present Indian regulation of surrogacy. One pertains to the 2015 earthquake in Nepal, when the Israeli government arranged to bring back Israeli gay couples and their babies from Kathmandu while the surrogate mothers were left to fend for themselves. Thailand, another hub for transnational surrogacy arrangements, banned commercial surrogacy for foreigners in 2015, in the aftermath of the Baby Gammy case and the Mitsutoki Shigeta case in 2014.

In 2016, the Indian Surrogacy (Regulation) Bill was approved by the union cabinet,2which banned all commercial surrogacy, and prohibited foreigners from accessing surrogacy in the country, while permitting altruistic surrogacy for married couples with documented infertility, provided they use a close relative for the procedure. In August 2019, a revised version of the 2016 bill was passed by the Lok Sabha. Arguably, the intent of this bill was to prevent the oppression embedded in the idea of rent a womb, while simultaneously strengthening cultural nationalism. This was evident in the statements made by the external affairs minister, the late Sushma Swaraj, who claimed that the bill hadan Indian ethos, aligned with our [Hindu] values (Hindu2016). Nonetheless, within the ambit of economic globalisation and Prime Minister Narendra Modis nationalist ideology, Indian womens responsibilities remain bracketed as reproducersshifting marginally from (re)producers for the global bioeconomies (within the logics of outsourcing) to procreators for the Indian nation (as mothers of the nation).

Reproductive Rights vs Reproductive Justice

Western feminist discourses on reproductive rights have been centred around values, such as choice and bodily autonomy and have primarily concerned the right to access birth control. This discourse has been criticised by feminists of colour for not addressing the ways in which socio-economic contexts and geopolitical locations shape womens reproductive realities (Twine 2015). They draw attention to how childbearing by privileged women is encouraged and bolstered through the use of advanced technological interventions, while poor women of colour are subject to public policy measures that include invasive and abusive medical procedures, or forced child removal that prohibitmotherhood (Roberts 1996: 944).

Challenging Western liberal notions of reproductive rights, the concept of reproductive justice was coined in the early 1990s. Merging reproductive rights with social justice, this concept addresses how race- and class-based histories of population control, sterilisation abuse, high-risk contraception, poverty, and the effects of environmental pollution on fertility and maternal health shaped the reproductive lives of the third world (as well as women of colour in the first world) (Bailey 2011: 727; Ross and Solinger 2017; Mohapatra 2012). It decentres abortion and contraception to emphasise how issues, such as incarceration, immigration, racism, housing, and adoption policies affect biological and social reproduction. The political dimension of reproduction is visible in current geopolitical conflicts, exemplified by the implementation of the United States (US) zero-tolerance policy at the Mexican border in 2018, and the coerced abortion and sterilisation of Muslim Uyghurss, Kazakhs and other minority groups of women by the Chinese state in 2020 (Briggs 2012).

A reproductive justice perspective is particularly relevant in the Indian setting given the symbiosis between reproductive politics, eugenics and neo-Malthusian ideologies, which have shaped the ideas of over-population during the early 20th century. Neo-Malthusian concerns were transformed into upper-caste anxieties about the lower castes. Upper-class neo-Malthusian agenda interweaved with the upper-caste agenda of Brahminical Hinduism to reduce women to merely reproductive bodies requiring male control, in a reimbrication of patriarchy (Anandhi 1998). In the initial debates on birth control, the seamless welding of Hindu with upper castes, and the conflation of upper-caste practices and norms as Hindu was achieved (Rao 2004: 3602). Central arguments concerned the reproductive excesses of the lower castes and religious minorities, in particular Muslims. Anandhi points out that several political groups articulated the opposition between desexualised reproductive bodies as the ideal norm of respectable female sexuality and sexual bodies as representing immoral and disreputable sexuality (Anandhi 1998: 145). From an international perspective, growing populations in China and India were increasingly seen as geopolitical threats and third world womens sexual behaviour was specifically targeted (Wilson 2018: 92; Briggs 2002: 117).

The post-independence Indian state and policymakers in World WarIhave seen the bodies of poor women in India as waste and their reproduction as something to be controlled (Rao 2010; Wilson 2018). Negative eugenics has been aggressively practised in India and targeted towards vulnerable communities. The widespread use and abuse of sterilisation is a case in point, as exemplified by the Chhattisgarh sterilisation scandal in 2014 (Ghose 2018). With the exception of a short period of forced mass vasectomies between 1975 and 1977, female sterilisation has been the main instrument of Indias population policies and has been the most common form of contraception available since the late 1970s(Deomampo 2016: 40). We wish to draw attention to the way in which what was formerly considered as waste is transformed into sites of profit generation within the reproductive industry of the neo-liberal Indian state.

Colonial Legacies of the Indian Reproductive Industry

In 2011, Alison Bailey argued for a reproductive justice approach to Indian surrogacy, as a response to what she described as an ethnographic turn, replacing earlier studies focused on the normative and ethical dimensions of surrogacy arrangements: either claiming moral legitimacy by using a liberal discourse, which emphasises womens right to decide over their own bodies, or a Marxist understanding, which perceives surrogacy as exploitation and the ultimate human commodification. By focusing on womens agency and lived experiences, it avoids the Eurocentric fallacy of previous scholarshipthe taken for granted of a particular set of moral concernsthat runs the risk of distorting the realities of women in the global South:

The single-pointed focus on choice occidentalises Indian surrogacy work: it makes it difficult to raise questions about the kind of life a woman has to lead to make this work count as a good choice. It obscures the injustice behind these choices: the reality that, for many women, contract pregnancy is one of the few routes to attaining basic social goods such as housing, food, clean water, education and medical care. (Bailey 2011: 722)

Bailey sees Amrita Pandes work as emblematic of this ethnographic turn, as it evades the discursive colonialism of early writings on surrogacy by giving priority to the surrogate mothers own narratives (Mohanty 2003). Pande observes that these women explicitly reject the category of choice, speaking instead ofmajboori(a compulsion) and loyalty with their families. Her ethnographic accounts add a complexity that makes it impossible to see surrogacy as either a win-win situation or one that transforms surrogate mothers into passive victims of exploitation.

However, Bailey is critical of what she perceives as a lack of a normative perspective; a weak moral absenteeism, noting that [i]nterviews are oddly de-politicised, as if documenting surrogacy workers agency and then properly contextualising their choices is sufficient (Bailey 2011: 72526). Departing from the narratives of the surrogate mothers enables the scholar to address the problematics articulated by the women engaging in these practices (Bailey 2011). Reproductive justice, she argues, provides a theoretical framework capable of encompassing both the surrogates local moral worlds and reflections on the morality of a practice that builds on the labour of women living under abject conditions. Such a perspective is attentive to the acute intersectionality at work in practices ofARTs.

Jyotsna Agnihotri Gupta (2006) responds to a similar understanding of intersectionality and inequality when she argues for a transnational feminist response toARTs. As their impact varies significantly between different groups of women, Gupta perceivesARTsas a testing ground for transnational feminism. Her proposal is a framework based on human dignity: a moral framework that values individuals as ends in themselves and not as tools [and] which encompass(es) individual rights claims but go(es) beyond the narrow focus of individualism and autonomy for the protection of womens self-respect and human dignity (Gupta 2006: 35).

Guptas proposal is critically assessed by Michal Nahman (2008), who agrees with the need for a common feminist stance onARTs, but rejects turning to a universal notion of dignity and the human rights discourse that this notion is based on. Modelled on Western conceptions of the human, dignity was used as a tool during colonialism and capitalism to dehumanise and instrumentalise colonised people. Instead, Nahman foregrounds the logic of the marketplace by recognising how one may attempt to gain a sense of dignity within global capitalism by doing precisely what will perpetuate the system, buying and selling (Nahman 2008: 76). Nahmans approach includes a critical recognition of neo-liberal capitalisms capacity to assimilate and live off the very attempts aimed at resisting it. She advocates a shift of focus to the neo-liberal global forces that position women in situations where they feel a need to commodify their bodies at all. This includes being attentive to how certain bodies are perceived as potential biological material: [W]ho is positioned asmore appropriateto sell a bit of their body (Nahman 2008: 77).

Kalindi Voras (2008, 2009, 2012) work offers the kind of account that Nahman argues for. Whilst Black feminists (Roberts 1996; Twine 2015; Weinbaum 2019) have drawn attention to how the current market in reproductive labour is prefigured by theUSslave economy, Vora draws parallels between surrogacy and Indian indentured labour that replaced slave labour after 1807, when the trade in slaves was abolished within the British Empire (Vora 2009; Lowe 2015). She argues that the colonial past offers the conditions of possibility for the present international division of reproductive labour, that is, why some bodies and not others are seen as the possible sources of commodification.

Others note connections between surrogacy and colonialism tangentially, through Indias history of reproductive politics, leading scholars like Bailey (2011) to argue for a reproductive justice approach. Pande (2014) and Sharmila Rudrappa (2015) address Indias history of population control and coercive reproductive policies targeted against marginalised communities. While Pande acknowledges the paradox of an aggressively anti-natalist state becoming a global hub forARTprocedures, Rudrappa explicitly rejects the relevance of a reproductive rights approach to address the distinct stratifications of Indian society. Instead, she argues for a reproductive justice framework that accounts for the endemic social, political and economic inequalities among different communities which shape individuals abilities to access a good life (Rudrappa 2015: 170).

Intersectionality of Dalit Feminism

The assertions by Dalit feminists in the 1990shave been part of a discourse of dissent to both mainstream womens movements and male-dominated Dalit movement. Sharmila Rege (2018) argues that middle class, upper-caste womens experience, or alternatively Dalit male experience became universalised, resulting in a masculinisation of dalithood and a savarnisation of womanhood (Rege 1998, 2018: 12). Akin to these articulations, one of our research participants, an activist from Bengaluru, stated:

One of the things that I have been doing a lot is critiquing Indian feminists: there is a lack of connect [ion] with real life issues of marginalised women. But the fact is that they are the ones who set the agenda and basically define the issues which feminists talk about in India.

Dalit feminism implies an interrogation of privilege and discrimination embedded within the Ambedkarian notion of Brahminical patriarchy, a specific modality of patriarchy governed by a set of discriminatory levels constituting a hierarchical organisation of society based on caste, which is quite unique to the Indian subcontinent (Arya and Rathore 2020: 8). This graded inequality determines the location of all individuals according to caste and gender, with upper-caste men and lower-caste women at the beginning and end of the spectrum. The Ambedkarian understanding of caste positions endogamy as its grounding principle, which makes the control of womens sexuality central to caste ideology (Rege 1998: 165; Velayudhan 2018).

While both Dalit women and caste Hindu women are disempowered by patriarchal practices, Dalit and lower caste women are more prone to violence as they face oppression at three levels (i) caste, (ii) class, and (iii) gender (Dutt 2019; Moon 2000; Malik 1999), that is, the triple burden of economic marginalisation (low wage labourers working for upper-caste landowners as most of the land is owned by upper caste or upwardly mobile castes), caste discrimination, and gender subordination. Our research participants would commonly refer to this intersectionality of oppression. Thus, engaging with a Dalit feminist perspective demonstrates the importance of intersectionality for grasping gender inequality in India. However, prominent feminists, such as Nivedita Menon oppose its relevance to Indian feminism, which Dalit feminists have perceived as a reluctance on the part of mainstream feminists to acknowledge and address their own caste privilege (Menon 2020).

Towards a Dalit Feminist Standpoint Theory

A Dalit feminist standpoint, as elaborated by Rege (2018) and Kanchana Mahadevan (2020), has significant parallels to other feminist standpoint theories (Collins 2009; Harding 2004; Haraway 1988). Standpoint theory designates the epistemological shift that occurs when marginalised communities gain public voice, and foregrounds the concept of experience. The location of the subject affects the experience and thus the knowledge that it generates. From a Dalit feminist perspective, experience is the origin of knowledge, and like standpoint theories, power is seen as integral to epistemology. The failure of dominant groups to critically interrogate their advantaged situation makes their social position a disadvantaged one for generating knowledge. As stated by one of our research participants, a Dalit journalist: we need to articulate womens experience and theory from the perspective of the marginalised sections, which mainstream feminists clearly are not doing. Indian feminists lack an insight or an experience (...) the entire perspective that we would bring to the table. In the same vein, a social activist among our research participants describes the importance of having worked in the slums: my feminist theory sprung from there you know, and my understanding of caste, class, gender came from the slums that I work [in]. What is emphasised in these narratives is the importance of lived experience, a kind of knowledge that has been omitted from traditional epistemologies, which spans over a register that includes feelings and more elusive elements, what Linda Martn Alcoff (1996, 2008: 294) describes as textures.

Grounding knowledge in experience is democratic and provides an alternative to normative understandings. However, this does not imply a belief in unmediated authentic experience. Rather than a subject merely registering the imprint of reality which then qualifies as knowledge, experience is regarded as a dialectical process of collective articulation by persons belonging to conflicting social locations. As Alcoff elaborates

the oppressed do not have an epistemic privilege over understanding oppression generally; they are not more likely, for example, to know the causes of their oppression. However they are more likely to know the lived reality of the oppression, its emotional costs, its subtler manifestations, what it is like to live it. (Alcoff 2008: 294)

Claiming ones experience as the foundation of knowledge and theory is particularly audacious in the Indian context, where a divide has been instituted between theory (theoretical Brahmins) and experience (empirical shudras) (Patil 2020: 219; Guru 2020). As Cynthia Stephens (2009) suggests, Dalit feminist theoretical claim is a conscious effort to break the existing stereotype of Dalit women as mainly activists (doers) who have little to contribute (as thinkers) to ideological discourses in society, politics, governance, ethics, economics, and development.

There is a risk of subsuming Dalit feminism within dominant feminist discourse through a mere acknowledgement of difference, and making room for different voices from non-hegemonic locations within mainstream feminism (Harding 2008: 158). If that was sufficient, caste discrimination would be a concern only for Dalit and other lower-caste women, just as feminists of colour reject seeing race as something only they should attend to. Instead, seriously engaging with Dalit feminist perspectives entails challenging the dominant paradigm of thought. The goal is not difference in itself, but the relations of power that it legitimates. In Reges words, the aim is to address the social relations that convert difference into oppression (Rege 1998: 157). Here, there are significant parallels to Black feminist standpoint theory which challenges what counts as knowledge. Constructing new knowledge is crucial for empowerment because it provides alternatives to the way things are supposed to be (Collins 2009: 286). Reges idea of oppositional Dalit feminist pedagogies resonates with Black feminist thought when she describes that the importance of Dalit womens narratives lies in the potential to destabilise received truths and locate debates in the complexities and contradictions of historical life (Rege 1998: 133).

Importantly, standpoint theorys rethinking of experience is not an excluding gesture. The we designated by Dalit feminism is an acquired community. Although it may not be possible to speak as or for Dalit women, it is possible to reinvent oneself as a Dalit feminist, which entails rejecting the Brahminical, middle-class outlook that structures mainstream Indian feminism, and become sensitive to the specific disempowerment created by the intersection of caste, class and gender. Furthermore, as Gopal Guru (2020) points out, the subject of a Dalit feminist standpoint is not homogenous but multiple, heterogeneous, and sometimes even contradictory.

Caste, Sexuality and Reproductive Labour

Gender and caste are inseparable in both their material and cultural dimensions. Our analysis demonstrates how these intersections and interactions shape the choices Dalit women make in terms of labour and sexuality, not the least in the area of sexual labour. A characteristic way that our research participants approached commercial surrogacy was through the lens of sex work. Prabha Kotiswaran (2011) speaks of two international agendas having shaped perceptions on sex work in India during the last decades: the abolitionist movement and the antiHIV/AIDSprevention efforts. The abolitionist movement has gained force from the United Nations Global Initiative to Fight Human Trafficking (UNGIFT) launched in 2007. Through media representations, such as the Oscar-winning documentaryBorn into Brothelsdirected by Zana Briski and shot in 2004, set in Kolkatas red-light districts, third world enslaved sex workers have become pre-eminent examples of human trafficking (Kotiswaran 2011: 4). The Immoral Traffic (Prevention) Act (ITPA) conflates trafficking and sex work, which defines the discursive space for conversations on sex work in India.

Sex work is commonly referred to as forced labour or sexual slavery by our research participants; coercion and not choice is emphasised, and there are those among our participants that adhered to the abolitionist view, as the journalist who spoke of all commodification as problematic per se:anything that commercialises () the body () has to be seriously questioned. However, rather than radical feminist understandings of sex work, most of our participants highlighted the socio-economic conditions that make women turn to sex work as a livelihood. Entering the surrogacy industry is described as shaped by the same forces. As one of the Dalit academics and social activists with the experience of working with women in prostitution explained:

[R]ural women likeX, sex work, forced by the husband, by the family and also absence of work at the agricultural sector. All this made them ... it is not theirchoice. I feel no women will get into this kind of selling sex, also selling their wombs for surrogacy. And the ... the whole economic conditions forces them to get into this. And I blame the society which has the purityimpurity concept in everyones mind which is also the sexual purity. Where they dont bother about the purityimpurity and they have the sexuality aspect. The most exploited women are the Dalit women []. Surrogacy is another thing that we cannot accept []. One woman in our area she received`30,000 only.

The same academic/social activist said she knew of rural women forced into sex work as a result of cuts in educational budgets, which makes unaffordable private schooling the only remaining option. Lack of jobs and collapsing farm prices trap families who seek ways out through self-exploitation. In combating commercial surrogacy and sex workmodern kinds of slaverythe rejuvenation of the agricultural sector is key, she argues.

The traditional hierarchical political economy of labour on which caste reproduces itself and Dalit demands for dignity of life and labour have to some extent been addressed by constitutional provisions. The government has tried to aid the empowerment of marginalised communities, especially women, Scheduled Castes (SCs) and Scheduled Tribes (STs) through large anti-poverty alleviation programmes, such as the one under the Mahatma Gandhi National Rural Employment Guarantee Act (MGNREGA). But, the same social activist suggests that the government measures are not always sufficient:

they are getting very poor wages, now this uh ... hundred days work ...MGNREGAwork. It also comes once in a while, and then one job for one family, not all the family members are ... and uh how do you expect Dalit women to depend on this.

More specifically addressing reproductive issues, she reflects on the increasing medicalisation of childbirth and the rapid growth inARTclinics in her city. She also brings up the ways in which exposure to pollution and other environmental issues disproportionately affect marginalised communities, not the least in their reproductive lives: The implication of chemical fertilisers on reproductive health systems of women, they keep on talking about. So I feel somewhere that is also an issue. In bringing unequal access to essential resources, such as clean water to the conversation onARTs, she demonstrates an understanding of reproductive justice as intimately connected to social justice. Ultimately, she argues that sex work and surrogacy is a question of the economic realities that Dalit women are confronted with: We are questioning the failure of (the) economic system. So you know like, what is happening to agriculture? What is happening to the economics?

Surrogacy and sex work are seen as parallel social phenomena not only in relation to how social locations shape womens choice of becoming surrogate mothers, but also the conditions in which they find themselves once within the industry. As one of the Dalit academics/social activists stated:

[F]or instance this`30,000 paid to a Dalit woman may not be the case for the non-Dalit woman who may bargain better. With her colour, with her sort of you know social capital. She may bargain, she may have a choice of going into surrogacy and bargaining for better allowance, better kind of conditions of gestation, etc. That may not exist for the Dalit.

The narratives suggest that economic and other exploitative conditions of Dalit surrogates within the reproductive industry parallels the vulnerability of Dalits working in the sex industry. Furthermore, many of our participants referred to the historical exploitation of Dalit womens sexuality, and the practices of devadasis andjoginisas contributing to the coercive forces surrounding womens labour. As stated by one of the journalists:

We have experienced sexual slavery for ... for simply centuries, whereas mainstream feminists havent had this experience. So they should hardly be the ones, you know, wanting to talk about it. I feel we as a society have failed if women have to sell their vaginas or rent their wombs to survive. You see the question is not of reproductive freedom or choice.Where is the choice when they have no choice?.[our emphasis]

One of the academics specified, Dalit devadasis have nothing to do with the art of dancing at all, they never had temple inheritance () Dalit devadasis were performing a kind of temple prostitution. Following this historical pattern, lower caste women constitute the majority of sex workers in contemporary India. This academic drew attention to the embeddedness of prostitution in caste and class, which, as she points out, was referred to as slavery by B R Ambedkar in 1936.

These intersecting levels of gender, caste and class reveal inherent contradictions in the practices of untouchability, as Aloysius et al (2020: 177) notice,

no more apparent than in dominant castes physical or sexual violence against Dalit women, where an undisputed claim is assumed [on] their bodies. Moreover, the touch of the womens agricultural labour in the dominant castes fields and their domestic work in the dominant castes houses are interpreted as essential services that preclude the strict practice of untouchability.

Detailing the vulnerability of Dalit women working in upper-caste families, one of our academic research participants spoke about the endemic problem of sexual harassment:[T]here is a caste link there where the man of the house and the women of the house believe in some way that this woman is sexually available. As Suruchi Thapar-Bjrkert (2006: 782) argues, the ideological construction of purity/pollution are conveniently forgotten when pure upper caste men are engaged in sexual encounters with impure lower caste women. This is not to deny patriarchal inequalities in Dalit households. In fact, as one of our academic participants said, a lot of Dalit women in my own circles are treated very objectively, like objects in their own relationships. For example, in their families, the man is only educated because of the poverty. So all those things disable the women to talk about the next level of you know rights. So the first thing is to survive. To get food on her table, the second thing is to educate herself if possible, the third thing is to enter a healthy relationship where she is not you know insecure or unsafe.

What Dalit women are capable of pursuing as labour depends on these limiting circumstances of income-generation. One of the journalist participants explains that a framework of choice is uncommon among sex workers from Dalit and lower-caste communities: this is stigmatised, this is despised and yet they do it, exposed to constant violence. One of the academic participants elaborates on the notions of respect and dignity introduced by the journalist:

They dont have the choice. Precisely the kind of structural condition which Dalit women are embedded, the question is not to ask about the agency of Dalit women or to talk about the rhetoric of sex work being dignified, to convert it into a dignified work does not arise given the fact that its an extremely embedded kind of condition in which Dalit women go into sex work () So its not a question of you know sex work being a taboo, here the question [is] of who is performing the work? And this is where Dalit women are saying that inevitably all said and done despite all this kind of talk about giving dignity and self-respect, eventually it is our women who are performing it.

The research participants emphasis on the particular vulnerability of Dalit women and the exposure to violence that a life in prostitution often entails, articulates with the Dalit movements understanding of prostitution as caste exploitation: caste privilege sexually exploits women of lower castes and destroys their self-respect thereby preserving the unequal power relations of a caste-based society (Tambe 2008). While economic desperation and social marginalisation is a recurrent reason for entering into sex work and surrogacy, our research participants simultaneously emphasised how this counteracts the equally important struggle for dignity, as both sex work and surrogacy are stigmatised occupations in the Indian context. As reiterated by one of the social activists: money is not a matter, recognition in the society is the matter. Dignity! ... they are not recognised even by the family. The acute need for survival and the equally pressing struggle for respect become irreconcilable realities; seizing economic opportunity simultaneously enhances social vulnerability.

Dismissing the framework of choice and insisting on the importance of structural conditions resonate with debates on sexuality and labour in which Dalit feminists have become a divergent voice. The legislative ban on bar dancing, critiqued by mainstream feminists as moral policing and an attack on womens right to exercise agency, and stances on sex work, are cases in point (Makhija 2010). Partly as a de-exceptionalising and destigmatising move, and with reference to the first national survey of sex work in India,3sex work has been conceptualised by dominant feminists through the liberal framework of bodily autonomy, rights and choice (Menon 2020), whereas reports by the National Federation of Dalit Women (NFDW) and National Campaign on Dalit Human Rights (NCDHR)emphasising that a majority of sex workers come from lower caste backgroundspoint to the caste-ordained linkage between sexuality and labour. Thus, the social position of the women choosing sex work needs to be acknowledged, in addition to their economic status (Rege 1998: 44).

Brahminisation of Surrogacy

Female reproductive biology is a main generative site in the growing global biomarkets, including emerging stem cell industries that are dependent on high volumes of human embryos, oocytes, fetal tissue and umbilical cord blood (Cooper and Waldby 2008, 2014). The gaining ascendancy of oocyte economies in the aftermath of the new regulatory framework on surrogacy was an important revelation during the course of our interviews. The commercialisation of ova, in particular, surfaced when our research participants addressedLGBTQIA+ (lesbian, gay, bisexual, transgender, queer, intersexed, and agender) communities acute lack of livelihood choices. Several of our research participants spoke of an expanding bio-economy in which lesbians and transgender persons sell their eggs and sperms as a mode of survival. As one of our research participants detailed, transmen and lesbians have very difficult time continuing their education because of family, they run away from home or because they have tough lives. So they are outside, they need money. They are running you know, running scared.

Our research participants give us reason to believe that these practices are inflected by gender, class and caste dynamics, as is surrogacy. One of the journalists shared the following account:

[T]he doctors I have discussed with at that time have told me [] they want fair looking babies, they want intelligent babies so they openly ask for Brahmin eggs. Some doctors have told me that people openly ask for some Brahmin eggs, or Brahmin sperm. So for uterus they are hiring lower caste people ... women They wont opt [for] their eggs () but for eggs and sperm they only seek upper caste [donors].

Brahmin eggs and Brahmin sperm are juxtaposed with the womb of the lower-caste woman, whose defiled and impure sexuality makes their own eggs undesirable. As earlier studies suggest, intended parents would ideally prefer a higher caste or Brahmin surrogate, with the expectation that they would produce healthy and good-looking babies (Dhar 2012). Nonetheless, both these cases reinstate the ideology of purity/pollution, whereby the institutionalised inequalities of the Brahminical system are fortified. We suggest that these reproductive practices assist in building caste capital, which confers benefits comparable to those accrued from social capital. As embodied in relations among persons (Coleman 1988: 118), social capital is productive and enables the achievement of certain ends while conferring power and profit to its holders (Skeggs 1998)in this case upper-caste women and menwhose caste capital protect them from economic and social vulnerability. We conceptualise this assemblage of practices as the Brahminisation of Surrogacy; creating new roles for lower caste women while confining them within the frame of non-valuable breeders for the embryos of valuable women (Corea 1985: 276). Significantly, such practices articulate with earlier Indian eugenic discourses and more recent Hindu nationalist arguments on caste supremacy, which construct oppressed castes as unfit to reproduce.

In conclusion, we reinstate the central purpose of our article which was to analyse caste as a significant parameter for understandingARTs, in particular surrogacy and egg donation. By incorporating Dalit feminist perspectives, that have been marginalised in mainstream debates, we demonstrate the relevance of bringing caste and social justice centre stage, and how this is crucial for forging new conversations.

Notes

1 Semi-structured qualitative in-depth qualitative interviews were conducted by the third author with 11 research participants, all of whom identified as women, who work in areas of reproductive healthas activists, journalists and academicsand who are from the Dalit caste. The respondents are based in Bengaluru (Karnataka) and Chennai (Tamil Nadu).Karnataka and Tamil Nadu share a trajectory of strong Dalit movements, and more importantly, Dalit womens movements in which our research participants are involved. Not all the participants identified as primarily Dalits. Some of them, especially the academics, emphasised that they were feminists who were also Dalits. The interviews were conducted in locations suggested by the participants: in their offices, homes and in cafes.

2 The Surrogacy (Regulation) Bill, 2016. The Ministry of Health and Welfare, Government of India, New Delhi, Bill No 257, https://dhr.gov.in/document/acts-circulars/surrogacy-regulation-bill-2016.

3 The survey was published in 2012, and indicates that approximately 71% of female sex-workers have chosen sex-work ahead of other occupations (www.plri.org).

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Dalit Feminist Voices on Reproductive Rights and Reproductive Justice - Economic and Political Weekly

Like rose-colored glasses, a ‘sexy mindset’ helps you see what you want to see – University of Rochester

September 22, 2020

Researchers find that having a sexy mindset makes people perceive potential partners as way more attractive.

Theres something to rose-tinted glasses after all.

A group of psychologists at the University of Rochester and the Israeli-based Interdisciplinary Center (IDC) Herzliya discovered that we see possible romantic partners as a lot more attractive if we have what the scientists call a sexy mindset. Under the same condition we also tend to overestimate our own chances of romantic success.

The researchers examined what would happen if a persons sexual system is activatedthink feeling friskyby exposing test subjects to brief sexual cues that induced a sexy mindset. Such a mindset, the team found, reduced a persons concerns about being rejected, while simultaneously inducing a sense of urgency to start a romantic relationship.

The US-Israeli team noticed that people often have overly optimistic views when it comes to a potential partner and their own chances of landing a date. Their latest research, published in the Journal of Social and Personal Relationships, sought to explain the biased perception. Its precisely this bias, the team concluded, that may provide people with the necessary confidence to worry less about rejection and instead motivate them to take a leap of faith to pursue a desired romantic relationship without hesitation.

If people anticipate that a partner shares their attraction, it is that much easier to initiate contact, because the fear of rejection is lessenedcoauthor Harry Reis, a professor of psychology and the Deans Professor in Arts, Sciences & Engineering at Rochester

People are more likely to desire potential partners and to project their desires onto them when sexually aroused, says lead author Gurit Birnbaum, a social psychologist and associate professor of psychology at the IDC. Our findings suggest that the sexual system prepares the ground for forming relationships by biasing interpersonal perceptions in a way that motivates human beings to connect. Clearly the sexual system does so by inspiring interest in potential partners, which, in turn, biases the perceptions of a potential partners interest in oneself.

Having evolved over millennia, the sexual behavioral system of humans ensures reproduction and survival of the species by arousing sexual urges that motivate us to pursue mates. Success depends on targeting the right potential partners who are not only perceived as desirable but also as likely to reciprocate our advances. In previous studies the researchers found that people often refrain from courting desirable possible partners because they fear rejection.

Forming stable sexual relationships had, and continues to have, a great deal of evolutionary significance, says study coauthor Harry Reis, a professor of psychology and the Deans Professor in Arts, Sciences & Engineering at Rochester.

If people anticipate that a partner shares their attraction, it is that much easier to initiate contact, because the fear of rejection is lessened, says Reis. One of the main purposes of sexual attraction is to motivate people to initiate relationships with potentially valuable, and valued, partners.

Across three experiments the team discovered that sexual activation helps people initiate relationships by inducing them to project their own desires onto prospective partners. In other wordsyou see what you want to see if youve been sexually primed.

To test the effects of a sexy mindset, the team exposed participants across three sperate studies either to sexual (but not pornographic) stimuli or to neutral stimuli. Next, the participants encountered a potential partner and rated this partners attractiveness and romantic interest in them. Participants interest in the partner was self-reported or evaluated by raters.

In the first study, 112 heterosexual participants, aged 20 to 32, who were not in a romantic relationship, were randomly paired with an unacquainted participant of the other sex. First, participants introduced themselves to each other by talking about their hobbies, positive traits, and future career plans while being videotaped. Then the team coded the videotaped introductions for nonverbal expressions of so-called immediacy behaviorsuch as close physical proximity, frequent eye contact, and flashing smilesthat indicates interest in initiating romantic relationships. They discovered that those participants exposed to a sexual stimulus (versus those exposed to the neutral stimulus) exhibited more immediacy behaviors toward potential partners and perceived the partners as more attractive and interested in them.

For the second study, 150 heterosexual participants, aged 19 to 30, who were not in a romantic relationship, served as a control for the potential partners attractiveness and reactions. Here, all participants watched the same prerecorded video introduction of a potential partner of the other sex and then introduced themselves to the partner while being videotaped. The team coded the videotapes for attempts to induce a favorable impression. Just as in the first study, the researchers found that activation of the sexual system led participants to perceive potential partners as more attractive as well as more interested in a romantic relationship.

In the third study, the team investigated whether a participants romantic interest in the other participant might explain why sexual activation affects perceptions of others romantic interest in oneself. Here, 120 heterosexual participants, aged 21 to 31, who were not in a romantic relationship, interacted online with another participant, who in reality was an attractive opposite-sex member of the research team, in a get-to-know-each-other conversation. The participants rated their romantic interest in the other person as well as that persons attractiveness and interest in them. They found again that sexual activation increased a participants romantic interest in the other participant, which, in turn, predicted perceiving the other as more interested in oneself. Having active sexual thoughts apparently arouses romantic interest in a prospective partner and encourages the adoption of an optimistic outlook on courting prospects with a partner, concluded the researchers.

Sexual feelings do more than just motivate us to seek out partners. It also leads us to project our feelings onto the other person, says Reis. One important finding of the study is that the sexual feelings need not come from the other person; they can be aroused in any number of ways that have nothing to do with the other person.

Yet, theres also the obvious possible pitfall: when sexual feelings are present, people tend to assume that the other person shares their attraction, whether warranted or not, notes Reis. Or you end up kissing a lot of frogs, adds Birnbaum, because a sexy mood makes you mistake them for princes.

Birnbaum and Reis have spent the last few decades studying the dynamics of human sexual attraction. In a 2019 study, the duo found that when people feel greater certainty that a prospective romantic partner reciprocates their interest, they will put more effort into seeing that person again. Furthermore, people will rate the possible date as more sexually attractive than they would if they were less certain about the prospective dates romantic intentions.

The research team for the latest study, which was supported by the Binational Science Foundation (BSF) also included Mor Iluz, Einat Plotkin, Lihi Tibi and Ronit Hematian at the IDC, and Moran Mizrahi at Ariel University.

Tags: Arts and Sciences, Department of Psychology, Gurit Birnbaum, Harry Reis, research

Category: Society & Culture

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Like rose-colored glasses, a 'sexy mindset' helps you see what you want to see - University of Rochester

America’s Ugly History With Selective Sterilization Against Women of Color – POPSUGAR

A prisoner shines a light from a window at an LA ICE detention center.

Last week, Dawn Wooten became the latest whistleblower regarding the treatment of migrants inside US Immigration and Customs Enforcement (ICE) facilities. A former detention center nurse, Wooten filed a claim with the Department of Homeland Security claiming that mass hysterectomies were being performed on women without their full consent and sometimes, without their knowledge.

These allegations rightfully shocked many, as politicians, celebrities and social media users drew comparisons between ICE conditions and Nazi Germany. But forced sterilization in America is not a random imitation of Nazi's eugenic history; it's a vile continuation of our own. In fact, it was California's mass sterilization in the 1920s, then recorded by the Eugenics Record Office, that in part helped form Hilter's blueprint for racial purification in Germany. Eugenics is the belief that the human species can be improved by preselecting those with "desirable" traits to reproduce in an effort to "breed out" disease, criminal traits, and mental illness.

In the early 1900s, sterilization in America thrived through federally funded programs used to control growing Asian and Mexican immigrant populations in the west and Black populations in the south. Originally targeting "undesirable" genes in people with criminal records and mental illnesses, it strategically evolved to include immigrants, people of color, and low-income citizens soon after. These programs purposefully sought out the most vulnerable communities, with victims who legally and financially could not fight against a government that had already predetermined their fate.

Below is a brief timeline of our country's history with sterilization, which has disproportionately affected women of color for more than 100 years.

The Eugenics movement enters the American political and economic system in an effort to eliminate "unfavorable" genetics of people with disabilities and those perceived as "socially inferior."

Michigan is the first state to introduce a compulsory sterilization bill. It does not pass.

Pennsylvania passes a sterilization bill that is later vetoed.

Indiana becomes the first state to legally pass eugenics laws and mandate sterilization of the "feebleminded," criminals, and "imbeciles."

By this year, 12 states, including California, Connecticut, and Washington, have some form of sterilization legislation in place.

By this time, 3,000 people have already been involuntarily sterilized in the country since the eugenics movement began.

Virginia's Eugenical Sterilization Act is signed into law under the guidance of Dr. Albert Priddy, the first superintendent of the Virginia Colony for Epilectics. Later that year, Priddy presents 18 subjects (all women) for a sterilization case study. The first proposed subject is Carrie Buck a 17-year-old pregnant girl who was raped by her foster family's nephew.

In Buck v. Bell, the Supreme Court approves the sterilization of individuals in all public institutions showcasing characteristics of "imbecility, epilepsy, and feeblemindedness." This included Priddy's first subject case, Buck, who became the first patient in America to face a legally mandated sterilization.

Sterilization begins in Puerto Rico. Approximately one-third of all Puerto Rican women were sterilized up until the 1970s.

Elaine Riddick, a 14-year-old Black girl in North Carolina is recommended for sterilization by a social worker after being raped. Her procedure is signed with an "x" by her illiterate grandmother, who was not informed of the procedure.

A five-person committee in North Carolina begins a sterilization program that lasts 45 years, sterilizing over 7,600 women, children, and men of color.

Two Black, mentally disabled sisters, Mary Alice Relf, 14, and Minnie Relf, 12, are sterilized without consent in Alabama after doctors tell their illiterate mother they were receiving birth control shots.

The Relf v. Weinberger case draws nationwide attention to the 100,000-150,000 people being involuntarily sterilized each year across the country.

By this year, 20 to 25 percent of Indigenous women have undergone forced sterilization in America since 1970.

In Madrigal v. Quilligan, the Supreme Court sides with Los Angeles County USC Medical Center, refusing to acknowledge coercion used to sterilize 10 female Mexican-American patients, despite a whistleblower going on the record.

By this year, California is responsible for 20,000 sterilization procedures, the highest number of any state.

Since 2006, almost 150 female prisoners in California have been secretly and illegally sterilized.

The Eugenics Compensation Act is signed into law to provide protections and reparations for victims.

As you can see, this is a devastating history, and one that isn't widely known. These eugenics methods were intentional tactics to disrupt the history and lineage of families and cultures. This drive to control marginalized groups, especially women of color, still has roots in our reproduction rights and decisions today.

If you're interested in learning more about America's history of sterilization, documentaries are a great place to start. I recommend watching The Eugenics Crusade (available on PBS and Amazon Prime) about the origins of eugenics and its role in American history. To learn how sterilization affected women specifically, No Ms Bebs (available on PBS) is a documentary about California's history of sterilizing Latina women, and Belly of the Beast is a documentary about the recent sterilizations in California's female prisons, premiering next month.

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America's Ugly History With Selective Sterilization Against Women of Color - POPSUGAR

‘Me First!’: Vaccine Nationalism and the Tragedy of Human Insecurity – The McGill International Review

Eight months into the COVID-19 pandemic, healthcare systems have been stretched to their limits after over half a million deaths, and the global economy has taken a hit unseen since the Great Depression. Until this point, the desperate international community has viewed a vaccine as the cure-all to the crisis. Such vaccines typically require up to ten years of research and testing before reaching the market. Still, scientists internationally are racing to create a safe and effective COVID-19 vaccine by next year. With more than 165 vaccines currently in development and 32 already in human trials, it has become clear that top vaccine-manufacturing nations are already competing to secure early access.

Though global health solutions warrant a coordinated global response, international cooperation to fight COVID-19 has been absent. With national interests beating out global cooperation, the global race to a coronavirus vaccine has morphed into something of a scientific gold rush with geopolitical undertones. In this risky game of vaccine nationalism, the scramble to a pandemic solution poses top-down consequences: a dangerous playing ground for major powers unchecked ambitions, and one that only breeds human insecurity.

With vaccine nationalism, self-interested states undertake a me-first approach to the development and distribution of vaccines and vie to secure doses of the vaccine for their own citizens before they are made available to the rest of the world. This nationalistic behaviour has been observed during COVID-19, with countries pumping the most money into their home teams.

When it comes to creating the vaccine, the US has opted to take an America Alone stance, which only further affirms the US abdication of global leadership. Acting on his pledge to deliver an American vaccine by the end of the year, President Trump in April announced that the US would be embarking on Operation Warp Speed, a federal initiative to coordinate efforts and fast-track the development of a coronavirus vaccine. Through this operation, the US has cut billion-dollar advance deals with pharmaceutical and manufacturing companies for exclusive access to millions of doses. For many observers, Trumps Operation Warp Speed translates as an extension of his America First political agenda. Accordingly, with the US retreat from multilateralism, the overarching assumption in the international community is that Trump will seek to vaccinate Americans first with an American vaccine.

While vaccine nationalism alone poses a credible threat to populations around the globe, it also serves as a dangerous proxy for geopolitical tensions. The race to develop a COVID-19 vaccine holds great rewards for the victor; achieving such a prominent scientific victory would signify economic recovery and national glory. Inevitably, this pursuit has resulted in the deep politicization of vaccine development. While public health should indeed be paramount for leaders, adopting a zero-sum approach does more harm than good.

At the forefront of COVID-19s nationalistic vaccine-geopolitics is the rivalry between the worlds two superpowers, the US and China. Since the outbreak of the pandemic, the US has underscored an accusatory China-virus rhetoric that has only succeeded in pushing the rapidly deteriorating US-China relationship into a dangerous phase unlike anything seen in fifty years. In competing quests for political glory, both superpowers are deviating from the multilateral path, opting instead to pour resources en masse into their respective national vaccine efforts. For the US, winning the race before the presidential election would fulfill Trumps America First agenda and secure a victory to boast over China. For China, on the other hand, the pandemic presents a unique opportunity to repent for its initial failures in Wuhan; a chance to project its soft power, rebuild its influence, and brand itself as a responsible nation, in contrast to the Western democracies that have demonstrated reprehensible pandemic responses. Beijings urgency has been highlighted in its plans to vaccinate its soldiers first, a military-civil fusion between the vaccine developer CanSino and the Peoples Liberation Army. To be the first to the coronavirus vaccine would mean cementing Chinas position as a viable candidate for global leadership a role it has sought to fill in Americas place.

Other authoritarian rivals like Russia have also engaged in vaccine nationalism. For the Kremlin, being first to the vaccine is a matter of national prestige as it tries to assert the image of Russia as a global power of stature capable of competing with the US and China. On July 17, Russian drugmaker R-Pharm announced a licensing deal with British pharmaceutical manufacturer AstraZeneca to transfer the entire process for full reproduction of the University of Oxfords COVID-19 vaccine in Russia. Russias AstraZeneca deal follows accusations from the Canadian, British, and American governments of the Kremlins attempt to steal vaccine data. While the Russian government denies these charges, the allegations draw attention to Russias nationalistic behaviour amid the pandemic. Not only does Russias AstraZeneca deal secure its doses of a potentially successful Oxford vaccine, but it also complements the nations attempts to produce its own. This proved to be the case when, on August 11, Russia announced that it was the first country to secure regulatory approval of its vaccine, Sputnik-V an alarmingly quick, albeit rushed feat that has created worry among many members of the international community.

While these countries are doing what it takes to compete for the cure, the lower-level outcomes prove rather contradictory to the principles of global public health and vaccine development. Such projects typically entail a collaborative effort between multiple parties from different countries not one in which wealthy nations in pursuit of political clout fail to ensure human security.

With developed nations erecting barriers to vaccine access, the issue of vaccine distribution has become a challenge of supply and demand. The most proximate consequence of vaccine nationalism sees a disproportionate burden placed onto the worlds vulnerable populations as the coronavirus cure becomes a private good inaccessible to both developed and developing nations.

Known for its notoriously high drug prices, the United States provides a prime example of vaccine nationalisms shortcomings in wealthy countries. Medical monopolies hold the power to steer vaccine distribution and threaten to limit supply. Thus, Americans in need become priced-out. As the Trump administration attempts to buy exclusive rights to a coronavirus vaccine, it is very possible that it will be priced far too high for many Americans. In February, US Secretary of Health and Human Services Alex Azar told Congress that the government will not intervene to guarantee the affordability of COVID-19 vaccines for Americans. In such a case, with a lifesaving vaccine inaccessible to many underinsured and marginalized communities, only more lives will be lost.

For developing countries with less bargaining power and resources, populations are left insecure as major powers rush to hoard vaccine doses. Such a failure of the international community was observed during the swine flu pandemic in 2009, when wealthier countries monopolized the initial supply of the vaccine. A repeat of the tragedy poses numerous consequences; for one, poorer nations will be forced to watch as their wealthier counterparts deplete supplies, allowing high-risk people to go unprotected in the interim of vaccine replenishment. The pressures of vaccine nationalism may even force desperate countries to block the export of vital vaccine components, leading to the breakdown of supply chains. In short, vaccine nationalism, in its paradoxical neglect of public welfare, only succeeds in extending the pandemic.

The threat of vaccine nationalism is well recognized, as some countries and health organizations have taken it upon themselves to develop preventative mechanisms. One of the most prominent of these efforts is the COVID-19 Vaccine Global Access (COVAX) Facility, a fund that, much like the US, invests into vaccine candidatesthis time on behalf of the rest of the world. While such initiatives bring an optimistic light to COVID-19 and the possibility of global cooperation, the dire reality of the situation is that the latent ability of any nation to jeopardize access to the vaccine only succeeds in undermining the collective effort thus extending the pandemic. As long as vaccine nationalism persists, nobody is safe until everybody is safe.

Featured Image: This untitled image is in the public domain

Edited by Nina Russell

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'Me First!': Vaccine Nationalism and the Tragedy of Human Insecurity - The McGill International Review

In Dark Times, I Sought Out the Turmoil of Caravaggios Paintings – The New York Times

Less than a year after I went to Naples, the Metropolitan Museum received The Martyrdom of St. Ursula on loan. I was able to see it side by side with The Denial of St. Peter, which is in the Mets collection. Because we know he died not long after, we cannot help reading these paintings through the lens of a late style, as works that convey both the tremendous skill of the artist and his sense of hurry. They are paintings of great economy and psychological depth. The fear in St. Peters eyes, the grief on St. Ursulas face: Was this the insight of a man who knew his life was almost over? Its tempting to think so. But Caravaggio expected to recover from his injuries of the previous year. He expected a pardon from the pope. Even with a large body of work behind him already, he was only 38. He must have thought he was just getting started. He wasnt moving from life into death, like John the Baptist. He was moving from death back into life, like Lazarus. So he thought; so he hoped.

It was in the summer of 1610 that Caravaggio received word that a pardon was being arranged for him in Rome, with the involvement of his old patron Cardinal Scipione Borghese. He left Naples on a felucca, a sailing boat, in the middle of July, taking three paintings with him as presents for the cardinal. A week later, he was in Palo, a coastal fort town 20 miles west of Rome, from which he presumably planned to make his way to the city. But something went wrong in Palo. On disembarking, Caravaggio got into a scuffle with the officers of the fort and was arrested. The felucca set sail without him but with his paintings still on board. It headed north to the coast of Tuscany, to the small town of Porto Ercole. Possibly there was another passenger to drop off. When Caravaggio was released, days later, he hurried over land in the direction of Porto Ercole, a days ride. Upon arrival, he collapsed in an exhausted heap. The felucca arrived around the same time.

It was a hot July day in 2016 when I headed to Porto Ercole. My train from Rome passed by Palo after about 30 minutes and arrived in Orbetello-Monte Argentario an hour and a half later. I imagined it could have been a fever-inducing journey in July 1610. I stayed in Orbetello and took a taxi from there the following morning, across a spit of land that ends in the promontory of Monte Argentario, on the southern side of which is Porto Ercole. I had breakfast at a cafe on the rocky beach. A quartet of visitors was seated near me, two of them, from their accents, American. One American was an older man. Well maybe this guy will win the election, and he can put an end to all that, the man said. Political correctness is just crazy. Youre not even allowed to compliment anyone anymore. Theyll cry sexual harassment. He held forth with the attitude of one who wished to be overheard. He complained about his ex-wife. The other three companions nodded sympathetically.

Caravaggio never painted the sea. I search his oeuvre in vain for a seascape; vistas of any kind are rare. We can address only what has survived of his work, and in what has survived, there are no swells, no waves, no oceanic calms, no shipwrecks or beaches, no sunsets over water. And yet his final years made a chart of the sea, and his ports of call were all literal ports, portals of hope, of which Porto Ercole was the final, unanticipated stop. Hes buried somewhere there, perhaps on the beach, perhaps in a local church. But his real body can be said to be elsewhere: the body, that is, of his painterly achievement, which has gone out to dozens of other places around the world, all the places where wall labels say d. 1610, Porto Ercole.

He was a murderer, a slaveholder, a terror and a pest. But I dont go to Caravaggio to be reminded of how good people are and certainly not because of how good he was. To the contrary: I seek him out for a certain kind of otherwise unbearable knowledge. Here was an artist who depicted fruit in its ripeness and at the moment it had begun to rot, an artist who painted flesh at its most delicately seductive and most grievously injured. When he showed suffering, he showed it so startlingly well because he was on both sides of it: He meted it out to others and received it in his own body. Caravaggio is long dead, as are his victims. What remains is the work, and I dont have to love him to know that I need to know what he knows, the knowledge that hums, centuries later, on the surface of his paintings, knowledge of all the pain, loneliness, beauty, fear and awful vulnerability our bodies have in common.

I walked down to the harbor in Porto Ercole. Small boats in their neat dozens bobbed on the water, and I asked one of the waiting men to take me out. The air was clear, the water a deep blue with faint hints of purple. For the second time on my journey, I got into a boat. We zipped along, and when the boatman took his shirt off, I did the same. He seemed to be in his early 50s, and he said he had always lived in Porto Ercole. He spoke little English. When I told him I was from New York, he grinned and gave me a thumbs up. Oh, New York! he said. We were a couple of miles out. Did he know of Caravaggio? Of course he did. He pointed to the beach. Caravaggio! he said, still smiling.

I signaled to him to cut the engine. It sputtered to a stop, and the silence came rushing in, so that the only sound was that of the waves lapping at the hull as the boat rose and fell on the Mediterranean.

Teju Cole is a writer and photographer. He wrote the magazines National Magazine Award-nominated On Photography column from 2015 to 2019. His novel Open City won the PEN/Hemingway Award in 2012 and the Internationaler Literaturpreis in 2013 and was on the short list for the National Book Critics Circle Award. His photo book Blind Spot was a finalist for the Paris Photo-Aperture Foundation First PhotoBook Award in 2017. Cole is a 2018 Guggenheim fellow and teaches writing at Harvard.

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In Dark Times, I Sought Out the Turmoil of Caravaggios Paintings - The New York Times

Verzenio Significantly Reduced the Risk of Cancer Recurrence by 25% for People with HR+, HER2- High Risk Early Breast Cancer – PRNewswire

INDIANAPOLIS, Sept. 20, 2020 /PRNewswire/ -- Eli Lilly and Company (NYSE: LLY) today announced Verzenio (abemaciclib) in combination with standard adjuvant endocrine therapy (ET) significantly decreased the risk of breast cancer recurrence by 25 percent compared to standard adjuvant ET alone for people with hormone receptor-positive (HR+), human epidermal growth factor receptor 2-negative (HER2-) high risk early breast cancer (HR: 0.747; 95% CI: 0.598, 0.932; p = 0.0096). This statistically significant benefit was consistent across all pre-specified subgroups and corresponds to a 3.5 percent difference between arms (92.2 percent in the Verzenio arm and 88.7 percent in the control arm) at two years. These results are from a preplanned interim analysis with 323 IDFS events observed in the intent-to-treat population across both arms, including 136 in the Verzenio arm and 187 in the control arm. The data were presented today in the Presidential Symposium at the European Society for Medical Oncology (ESMO) 2020 Virtual Congress and simultaneously published in the Journal of Clinical Oncology.

Safety data from monarchE were consistent with the known safety profile of Verzenio and no new safety signals were observed. At the time of analysis, approximately 70 percent of patients in each arm were still on the two-year treatment period. The median follow up was approximately 15.5 months in both arms. The median duration on Verzenio was 14 months.

"This is a major milestone for people living with high risk HR+, HER2- early breast cancer potentially one of the most notable treatment advances in the last two decades for this population of breast cancer patients," said Stephen Johnston, M.D., Ph.D., Professor of Breast Cancer Medicine and Consultant Medical Oncologist at The Royal Marsden NHS Foundation Trust (London, U.K.) and lead investigator for the monarchE trial. "Abemaciclib added to adjuvant endocrine therapy significantly improved invasive disease-free survival in women and men with HR+, HER2- early breast cancer at high risk of early recurrence, and if approved could represent a new standard of care for this population."

monarchE randomized 5,637 patients with HR+, HER2- high risk early breast cancer from more than 600 sites in 38 countries. High risk was defined by cancer that spread to the lymph nodes, a large tumor size, or high cellular proliferation (as determined by tumor grade or Ki-67 index). Patients were treated for two years (treatment period) or until meeting criteria for discontinuation. After the treatment period, all patients will continue ET for five to 10 years, as clinically indicated.

"We are excited that Verzenio has demonstrated a clinically meaningful reduction in the risk of recurrence for people with HR+, HER2- high risk early breast cancer, and Lilly would like to thank the patients and investigators around the world who made this trial possible," said Maura Dickler, M.D., vice president, late phase development, Lilly Oncology. "The results on invasive disease-free survival are significant and provide hope for people with high risk early breast cancer living with concerns of recurrence. Lilly will submit these results to regulatory bodies around the world as soon as possible and we look forward to being able to offer Verzenio as a new treatment option for these patients. We are proud of the way monarchE builds on the vast body of clinical evidence established for Verzenio."

The addition of Verzenio to endocrine therapy also resulted inan improvement in distant relapse-free survival, or the time to developing cancer that has spread to other parts of the body. The combination reduced the risk of developing metastatic disease by 28 percent (HR: 0.717; 95% CI: 0.559, 0.920), with the largest reductions occurring in rates of metastases to the liver and bone. This treatment benefit was consistent across all prespecified subgroups. Two-year distant relapse-free survival rates were 93.6 percent in the Verzenio arm and 90.3 percent in the control arm.

"The results of monarchE are welcome news for our community," said Jean Sachs, MSS, MLSP, CEO of Living Beyond Breast Cancer. "Up to 30 percent of people with hormone receptor-positive early breast cancer may have a recurrence, so this finding is an exciting development for those with high risk hormone receptor-positive, HER2- early breast cancer, especially because the trial included women of any menopausal status as well as men."

Overall survival results were immature and monarchE will continue through the completion date, estimated for June 2027. At the time of the interim analysis, the IDFS results are considered definitive. All patients on monarchE will be followed until primary analysis and beyond to assess overall survival and other endpoints. Lilly will submit the monarchE data to regulatory authorities before the end of 2020.

About the monarchE StudymonarchE is a Phase 3, multicenter, randomized, open-label trial that enrolled 5,637 patients with HR+, HER2- node-positive, high riskearly breast cancer. Patients were randomized 1:1 to Verzenio (150 mg twice daily) plus standard adjuvant endocrine therapy or standard adjuvant endocrine therapy alone. Patients were treated for two years (treatment period) or until meeting criteria for discontinuation. After the treatment period,all patients will continue on endocrine therapy for five to 10 years, as clinically indicated. The primary objective is invasive disease-free survival (IDFS)defined according to the Standard Definitions for Efficacy Endpoints (STEEP) criteria. In adjuvant breast cancer trials,thisincludes the length of time before any cancer comes back, a new cancer develops or death. Secondary objectives include distant relapse-free survival, overall survival, safety, pharmacokinetics and health outcomes.

High risk was specifically defined as women (any menopausal status) and men with resected HR+, HER2- invasive early breast cancer with either 4 pathologically positive axillary lymph nodes (ALNs) or 1 to 3 positive ALNs and at least one of the following high-risk features: primary invasive tumor size 5 cm, histological grade 3 tumor, or central Ki-67 index 20%. If applicable, patients must have also completed adjuvant chemotherapy and radiotherapy prior to enrolling and have recovered from all acute side effects.

About Early Breast CancerBreast cancer is the most common cancer among women worldwide.1 An estimated 90 percent of all breast cancer is diagnosed at an early stage.2 Approximately 70 percent of all breast cancers are HR+, HER2-, the most common subtype.3 Even within this subtype, HR+, HER2- breast cancer is a complex disease, and many factors such as if the cancer has spread to the lymph nodes and the biology of the tumor can impact the risk of recurrence. Approximately 30 percent of people diagnosed with HR+ early breast cancer are at risk of their cancer returning, potentially to incurable metastatic disease.4

About Verzenio (abemaciclib) Verzenio (abemaciclib) is an inhibitor of cyclin-dependent kinases (CDK)4 & 6, which are activated by binding to D-cyclins. In estrogen receptor-positive (ER+) breast cancer cell lines, cyclin D1 and CDK4 & 6 promote phosphorylation of the retinoblastoma protein (Rb), cell cycle progression, and cell proliferation.

In vitro, continuous exposure to Verzenio inhibited Rb phosphorylation and blocked progression from G1 to S phase of the cell cycle, resulting in senescence and apoptosis (cell death). Preclinically, Verzenio dosed daily without interruption resulted in reduction of tumor size. Inhibiting CDK4 & 6 in healthy cells can result in side effects, some of which may be serious. Clinical evidence also suggests that Verzenio crosses the blood-brain barrier. In patients with advanced cancer, including breast cancer, concentrations of Verzenio and its active metabolites (M2 and M20) in cerebrospinal fluid are comparable to unbound plasma concentrations.

Verzenio is Lilly's first solid oral dosage form to be made using a faster, more efficient process known as continuous manufacturing. Continuous manufacturing is a new and advanced type of manufacturing within the pharmaceutical industry, and Lilly is one of the first companies to use this technology.

INDICATION Verzenio is indicated for the treatment of HR+, HER2- advanced or metastatic breast cancer:

IMPORTANT SAFETY INFORMATION FOR VERZENIO (abemaciclib)

Diarrhea occurred in 81% of patients receiving Verzenio plus an aromatase inhibitor in MONARCH 3, 86% of patients receiving Verzenio plus fulvestrant in MONARCH 2 and 90% of patients receiving Verzenio alone in MONARCH 1. Grade 3 diarrhea occurred in 9% of patients receiving Verzenio plus an aromatase inhibitor in MONARCH 3, 13% of patients receiving Verzenio plus fulvestrant in MONARCH 2 and in 20% of patients receiving Verzenio alone in MONARCH 1. Episodes of diarrhea have been associated with dehydration and infection.

Diarrhea incidence was greatest during the first month of Verzenio dosing. In MONARCH 3, the median time to onset of the first diarrhea event was 8 days, and the median duration of diarrhea for Grades 2 and 3 were 11 and 8 days, respectively. In MONARCH 2, the median time to onset of the first diarrhea event was 6 days, and the median duration of diarrhea for Grades 2 and 3 were 9 days and 6 days, respectively. In MONARCH 3, 19% of patients with diarrhea required a dose omission and 13% required a dose reduction. In MONARCH 2, 22% of patients with diarrhea required a dose omission and 22% required a dose reduction. The time to onset and resolution for diarrhea were similar across MONARCH 3, MONARCH 2, and MONARCH 1.

Instruct patients that at the first sign of loose stools, they should start antidiarrheal therapy such as loperamide, increase oral fluids, and notify their healthcare provider for further instructions and appropriate follow-up. For Grade 3 or 4 diarrhea, or diarrhea that requires hospitalization, discontinue Verzenio until toxicity resolves to Grade 1, and then resume Verzenio at the next lower dose.

Neutropenia occurred in 41% of patients receiving Verzenio plus an aromatase inhibitor in MONARCH 3, 46% of patients receiving Verzenio plus fulvestrant in MONARCH 2 and 37% of patients receiving Verzenio alone in MONARCH 1. A Grade 3 decrease in neutrophil count (based on laboratory findings) occurred in 22% of patients receiving Verzenio plus an aromatase inhibitor in MONARCH 3, 32% of patients receiving Verzenio plus fulvestrant in MONARCH 2 and in 27% of patients receiving Verzenio alone in MONARCH 1. In MONARCH 3, the median time to first episode of Grade 3 neutropenia was 33 days, and in MONARCH 2 and MONARCH 1, was 29 days. In MONARCH 3, median duration of Grade 3 neutropenia was 11 days, and for MONARCH 2 and MONARCH 1 was 15 days.

Monitor complete blood counts prior to the start of Verzenio therapy, every 2 weeks for the first 2 months, monthly for the next 2 months, and as clinically indicated. Dose interruption, dose reduction, or delay in starting treatment cycles is recommended for patients who develop Grade 3 or 4 neutropenia.

Febrile neutropenia has been reported in <1% of patients exposed to Verzenio in the MONARCH studies. Two deaths due to neutropenic sepsis were observed in MONARCH 2. Inform patients to promptly report any episodes of fever to their healthcare provider.

Severe, life-threatening, or fatal interstitial lung disease (ILD) and/or pneumonitis can occur in patients treated with Verzenio and other CDK4/6 inhibitors. Across clinical trials (MONARCH 1, MONARCH 2, MONARCH 3), 3.3% of Verzenio-treated patients had ILD/pneumonitis of any grade, 0.6% had Grade 3 or 4, and 0.4% had fatal outcomes. Additional cases of ILD/pneumonitis have been observed in the post-marketing setting, with fatalities reported.

Monitor patients for pulmonary symptoms indicative of ILD/pneumonitis. Symptoms may include hypoxia, cough, dyspnea, or interstitial infiltrates on radiologic exams. Infectious, neoplastic, and other causes for such symptoms should be excluded by means of appropriate investigations.

Dose interruption or dose reduction is recommended in patients who develop persistent or recurrent Grade 2 ILD/pneumonitis. Permanently discontinue Verzenio in all patients with grade 3 or 4 ILD/pneumonitis.

Grade 3 increases in alanine aminotransferase (ALT) (6% versus 2%) and aspartate aminotransferase (AST) (3% versus 1%) were reported in the Verzenio and placebo arms, respectively, in MONARCH 3. Grade 3 increases in ALT (4% versus 2%) and AST (2% versus 3%) were reported in the Verzenio and placebo arms respectively, in MONARCH 2.

In MONARCH 3, for patients receiving Verzenio plus an aromatase inhibitor with Grade 3 increases in ALT or AST, median time to onset was 61 and 71 days, respectively, and median time to resolution to Grade <3 was 14 and 15 days, respectively. In MONARCH 2, for patients receiving Verzenio plus fulvestrant with Grade 3 increases in ALT or AST, median time to onset was 57 and 185 days, respectively, and median time to resolution to Grade <3 was 14 and 13 days, respectively.

For assessment of potential hepatotoxicity, monitor liver function tests (LFTs) prior to the start of Verzenio therapy, every 2 weeks for the first 2 months, monthly for the next 2 months, and as clinically indicated. Dose interruption, dose reduction, dose discontinuation, or delay in starting treatment cycles is recommended for patients who develop persistent or recurrent Grade 2, or Grade 3 or 4, hepatic transaminase elevation.

Venous thromboembolic events were reported in 5% of patients treated with Verzenio plus an aromatase inhibitor as compared to 0.6% of patients treated with an aromatase inhibitor plus placebo in MONARCH 3. Venous thromboembolic events were reported in 5% of patients treated with Verzenio plus fulvestrant in MONARCH 2 as compared to 0.9% of patients treated with fulvestrant plus placebo. Venous thromboembolic events included deep vein thrombosis, pulmonary embolism, pelvic venous thrombosis, cerebral venous sinus thrombosis, subclavian and axillary vein thrombosis, and inferior vena cava thrombosis. Across the clinical development program, deaths due to venous thromboembolism have been reported. Monitor patients for signs and symptoms of venous thrombosis and pulmonary embolism and treat as medically appropriate.

Verzenio can cause fetal harm when administered to a pregnant woman based on findings from animal studies and the mechanism of action. In animal reproduction studies, administration of abemaciclib to pregnant rats during the period of organogenesis caused teratogenicity and decreased fetal weight at maternal exposures that were similar to the human clinical exposure based on area under the curve (AUC) at the maximum recommended human dose. Advise pregnant women of the potential risk to a fetus. Advise females of reproductive potential to use effective contraception during treatment with Verzenio and for at least 3 weeks after the last dose. There are no data on the presence of Verzenio in human milk or its effects on the breastfed child or on milk production. Advise lactating women not to breastfeed during Verzenio treatment and for at least 3 weeks after the last dose because of the potential for serious adverse reactions in breastfed infants. Based on findings in animals, Verzenio may impair fertility in males of reproductive potential.

The most common adverse reactions (all grades, 10%) observed in MONARCH 3 for Verzenio plus anastrozole or letrozole and 2% higher than placebo plus anastrozole or letrozole vs placebo plus anastrozole or letrozole were diarrhea (81% vs 30%), neutropenia (41% vs 2%), fatigue (40% vs 32%), infections (39% vs 29%), nausea (39% vs 20%), abdominal pain (29% vs 12%), vomiting (28% vs 12%), anemia (28% vs 5%), alopecia (27% vs 11%), decreased appetite (24% vs 9%), leukopenia (21% vs 2%), creatinine increased (19% vs 4%), constipation (16% vs 12%), ALT increased (16% vs 7%), AST increased (15% vs 7%), rash (14% vs 5%), pruritus (13% vs 9%), cough (13% vs 9%), dyspnea (12% vs 6%), dizziness (11% vs 9%), weight decreased (10% vs 3%), influenza-like illness (10% vs 8%), and thrombocytopenia (10% vs 2%).

The most common adverse reactions (all grades, 10%) observed in MONARCH 2 for Verzenio plus fulvestrant and 2% higher than placebo plus fulvestrant vs placebo plus fulvestrant were diarrhea (86% vs 25%), neutropenia (46% vs 4%), fatigue (46% vs 32%), nausea (45% vs 23%), infections (43% vs 25%), abdominal pain (35% vs 16%), anemia (29% vs 4%), leukopenia (28% vs 2%), decreased appetite (27% vs 12%), vomiting (26% vs 10%), headache (20% vs 15%), dysgeusia (18% vs 3%), thrombocytopenia (16% vs 3%), alopecia (16% vs 2%), stomatitis (15% vs 10%), ALT increased (13% vs 5%), pruritus (13% vs 6%), cough (13% vs 11%), dizziness (12% vs 6%), AST increased (12% vs 7%), peripheral edema (12% vs 7%), creatinine increased (12% vs <1%), rash (11% vs 4%), pyrexia (11% vs 6%), and weight decreased (10% vs 2%).

The most common adverse reactions (all grades, 10%) observed in MONARCH 1 with Verzenio were diarrhea (90%), fatigue (65%), nausea (64%), decreased appetite (45%), abdominal pain (39%), neutropenia (37%), vomiting (35%), infections (31%), anemia (25%), thrombocytopenia (20%), headache (20%), cough (19%), leukopenia (17%), constipation (17%), arthralgia (15%), dry mouth (14%), weight decreased (14%), stomatitis (14%), creatinine increased (13%), alopecia (12%), dysgeusia (12%), pyrexia (11%), dizziness (11%), and dehydration (10%).

The most frequently reported 5% Grade 3 or 4 adverse reactions that occurred in the Verzenio arm vs the placebo arm of MONARCH 3 were neutropenia (22% vs 2%), diarrhea (9% vs 1%), leukopenia (8% vs <1%), ALT increased (7% vs 2%), and anemia (6% vs 1%).

The most frequently reported 5% Grade 3 or 4 adverse reactions that occurred in the Verzenio arm vs the placebo arm of MONARCH 2 were neutropenia (27% vs 2%), diarrhea (13% vs <1%), leukopenia (9% vs 0%), anemia (7% vs 1%), and infections (6% vs 3%).

The most frequently reported 5% Grade 3 or 4 adverse reactions from MONARCH 1 with Verzenio were neutropenia (24%), diarrhea (20%), fatigue (13%), infections (7%), leukopenia (6%), anemia (5%), and nausea (5%).

Lab abnormalities (all grades; Grade 3 or 4) for MONARCH 3 in 10% for Verzenio plus anastrozole or letrozole and 2% higher than placebo plus anastrozole or letrozole vs placebo plus anastrozole or letrozole were increased serum creatinine (98% vs 84%; 2% vs 0%), decreased white blood cells (82% vs 27%; 13% vs <1%), anemia (82% vs 28%; 2% vs 0%), decreased neutrophil count (80% vs 21%; 22% vs 3%), decreased lymphocyte count (53% vs 26%; 8% vs 2%), decreased platelet count (36% vs 12%; 2% vs <1%), increased ALT (48% vs 25%; 7% vs 2%), and increased AST (37% vs 23%; 4% vs <1%).

Lab abnormalities (all grades; Grade 3 or 4) for MONARCH 2 in 10% for Verzenio plus fulvestrant and 2% higher than placebo plus fulvestrant vs placebo plus fulvestrant were increased serum creatinine (98% vs 74%; 1% vs 0%), decreased white blood cells (90% vs 33%; 23% vs 1%), decreased neutrophil count (87% vs 30%; 33% vs 4%), anemia (84% vs 33%; 3% vs <1%), decreased lymphocyte count (63% vs 32%; 12% vs 2%), decreased platelet count (53% vs 15%; 2% vs 0%), increased ALT (41% vs 32%; 5% vs 1%), and increased AST (37% vs 25%; 4% vs 4%).

Lab abnormalities (all grades; Grade 3 or 4) for MONARCH 1 were increased serum creatinine (98%; <1%), decreased white blood cells (91%; 28%), decreased neutrophil count (88%; 27%), anemia (68%; 0%), decreased lymphocyte count (42%; 14%), decreased platelet count (41%; 2%), increased ALT (31%; 3%), and increased AST (30%; 4%).

Strong and moderate CYP3A inhibitors increased the exposure of abemaciclib plus its active metabolites to a clinically meaningful extent and may lead to increased toxicity. Avoid concomitant use of the strong CYP3A inhibitor ketoconazole. Ketoconazole is predicted to increase the AUC of abemaciclib by up to 16-fold. In patients with recommended starting doses of 200 mg twice daily or 150 mg twice daily, reduce the Verzenio dose to 100 mg twice daily with concomitant use ofstrong CYP3A inhibitors other than ketoconazole. In patients who have had a dose reduction to 100 mg twice daily due to adverse reactions, further reduce the Verzenio dose to 50 mg twice daily with concomitant use of strong CYP3A inhibitors. If a patient taking Verzenio discontinues a strong CYP3A inhibitor, increase the Verzenio dose (after 3 to 5 half-lives of the inhibitor) to the dose that was used before starting the inhibitor. With concomitant use of moderate CYP3A inhibitors, monitor for adverse reactions and consider reducing the Verzenio dose in 50 mg decrements. Patients should avoid grapefruit products.

Avoid concomitant use of strong or moderate CYP3A inducers and consider alternative agents. Coadministration of strong or moderate CYP3A inducers decreased the plasma concentrations of abemaciclib plus its active metabolites and may lead to reduced activity.

With severe hepatic impairment (Child-Pugh Class C), reduce the Verzenio dosing frequency to once daily. The pharmacokinetics of Verzenio in patients with severe renal impairment (CLcr <30 mL/min), end stage renal disease, or in patients on dialysis is unknown. No dosage adjustments are necessary in patients with mild or moderate hepatic (Child-Pugh A or B) and/or renal impairment (CLcr 30-89 mL/min).

AL HCP ISI 17SEP2019

Please see full Prescribing Information for Verzenio.

About Lilly Oncology For more than 50 years, Lilly has been dedicated to delivering life-changing medicines and support to people living with cancer and those who care for them. Lilly is determined to build on this heritage and continue making life better for all those affected by cancer around the world. To learn more about Lilly's commitment to people with cancer, please visit http://www.LillyOncology.com.

About Eli Lilly and Company Lilly is a global health care leader that unites caring with discovery to create medicines that make life better for people around the world. We were founded more than a century ago by a man committed to creating high-quality medicines that meet real needs, and today we remain true to that mission in all our work. Across the globe, Lilly employees work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to communities through philanthropy and volunteerism. To learn more about Lilly, please visit us at lilly.com and lilly.com/newsroom.P-LLY

Lilly USA, LLC 2020. ALL RIGHTS RESERVED.

Verzenio is a trademark owned by or licensed to Eli Lilly and Company, its subsidiaries, or affiliates.

This press release contains forward-looking statements (as that term is defined in the Private Securities Litigation Reform Act of 1995) about Verzenio (abemaciclib) as a treatment for patients with breast cancer and reflects Lilly's current beliefs. However, as with any pharmaceutical product, there are substantial risks and uncertainties in the process of development and commercialization. Among other things, there can be no guarantee that future study results will be consistent with the results to date or that Verzenio will receive additional regulatory approvals or be commercially successful. For further discussion of these and other risks and uncertainties, see Lilly's most recent Form 10-K and Form 10-Q filings with the United States Securities and Exchange Commission. Except as required by law, Lilly undertakes no duty to update forward-looking statements to reflect events after the date of this release.

1World Health Organization. Breast cancer: prevention and control. https://www.who.int/cancer/detection/breastcancer/en/index1.html. Accessed: September 8, 2020.

2Howlader N, et al. SEER Cancer Statistics Review, 1975-2013. http://seer.cancer.gov/csr/1975_2013/. Accessed: September 8, 2020.

3Howlader N, Altekruse S, Li C. US incidence of breast cancer subtypes defined by joint hormone receptor and HER2 status. J Natl Cancer Inst. 2014;106(5).

4Reinert T and Barrios CH. Optimal Management of Hormone Receptor Positive Metastatic Breast Cancer in 2016. Ther Adv Med Oncol. 2015;7(6):304-20.

SOURCE Eli Lilly and Company

http://www.lilly.com

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Verzenio Significantly Reduced the Risk of Cancer Recurrence by 25% for People with HR+, HER2- High Risk Early Breast Cancer - PRNewswire

This Week’s Awesome Tech Stories From Around the Web (Through September 19) – Singularity Hub

ARTIFICIAL INTELLIGENCE

How to Give A.I. a Pinch of ConsciousnessChris Baraniuk | OneZeroThat higher, attentive level of processing is not always necessary or even desirable but it seems to be crucial for humans to learn new skills or adapt to unexpected challenges. A.I. systems and robots could potentially avoid the stupidity that currently plagues them if only they could gain the same ability to prioritize, focus, and resolve a problem.

Synthetic Biologists Have Created a Slow-Growing Version of the Coronavirus to Give as a VaccineAntonio Regalado | MIT Tech ReviewIt might seem scary to imagine getting infected by the coronavirus on purpose, but attenuated-virus vaccines are common. The kids flu vaccine FluMist has a weakened influenza virus in it. And Serum Institute sells 750,000 doses a year of vaccines using live measles. The only disease ever successfully eradicated from the globe, smallpox, was wiped out with shots of a live virus.

IBM Publishes Its Quantum Roadmap, Says It Will Have a 1,000-Qubit Machine in 2023Frederic Lardinois | Tech CrunchGil believes that 2023 will be an inflection point in the industry, with the road to the 1,121-qubit machine driving improvements across the stack. The most importantand ambitiousof these performance improvements that IBM is trying to execute on is bringing down the error rate from about 1% today to something closer to 0.0001%.

Is There a Black Hole in Our Backyard?Dennis Overbye | The New York TimesWhat is an astrophysicist to do during a pandemic, except maybe daydream about having a private black hole? Although it is probably wishful thinking, some astronomers contend that a black hole may be lurking in the outer reaches of our solar system. All summer, they have been arguing over how to find it, if indeed it is there, and what to do about it, proposing plans that are only halfway out of this world.

This Tiny Reproduction ofGirl With a Pearl EarringIs Painted With LightJennifer Ouellette | Ars TechnicaScientists have fabricated tiny nanopillarscapable of transmitting specific colors of light, at specific intensities, which hold promise for improved optical communication and anti-counterfeit measures for currency. For proof of concept, they decided to digitally reproduce Dutch master Johannes Vermeers famous paintingGirl With a Pearl Earringjust painted in light instead of pigment.

Forget Planting Trees: This Company Is Making Carbon Offsets by Putting Seaweed on the Ocean FloorAdele Peters | Fast CompanyDone at a large scale, the process could make a meaningful difference. A 2019 study that looked at the potential for seaweed farming to offset carbon emissions calculated that growing and sinking macroalgae in a tiny fraction of the federal waters off the California coastline could fully offset emissions from the states enormous agriculture industry, for example.

Is the Internet Conscious? If It Were, How Would We Know?Meghan OGieblyn | WiredDoes the internetbehave like a creature with an internal life? Does it manifest the fruits of consciousness? There are certainly moments when it seems to. Google can anticipate what youre going to type before you fully articulate it to yourself. Facebook ads can intuit that a woman is pregnant before she tells her family and friends. It is easy, in such moments, to conclude that youre in the presence of another mindthough given the human tendency to anthropomorphize, we should be wary of quick conclusions.

Image credit:Juskteez Vu / Unsplash

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This Week's Awesome Tech Stories From Around the Web (Through September 19) - Singularity Hub

Viruses Are Both the Villains and Heroes of Life As We Know It Natures Powerhouses for Genetic Innovation – SciTechDaily

Bacteriophages are viruses that infect bacteria and play a potential role in the evolution of life.

Viruses have a bad reputation. They are responsible for the COVID-19 pandemic and a long list of maladies that have plagued humanity since time immemorial. Is there anything to celebrate about them?

Many biologists like me believe there is, at least for one specific type of virus namely, bacteriophages, or viruses that infect bacteria. When the DNA of these viruses is captured by a cell, it may contain instructions that enable that cell to perform new tricks.

Bacteriophages, or phages for short, keep bacterial populations in check, both on land and at sea. They kill up to 40% of the oceans bacteria every day, helping control bacterial blooms and redistribution of organic matter.

Bacteriophages are viruses that kill specific types of bacteria.

Their ability to selectively kill bacteria also has medical doctors excited. Natural and engineered phages have been successfully used to treat bacterial infections that do not respond to antibiotics. This process, known as phage therapy, could help fight antibiotic resistance.

Recent research points to another important function of phages: They may be natures ultimate genetic tinkerers, crafting novel genes that cells can retool to gain new functions.

Bacteriophage caspids can carry extra DNA that the virus can tinker with.

Phages are the most abundant life form on the planet, with a nonillion thats a 1 with 31 zeroes after it of them floating around the world at any moment. Like all viruses, phages also have high replication and mutation rates, meaning they form many variants with different characteristics each time they reproduce.

Most phages have a rigid shell called a capsid that is filled with their genetic material. In many cases, the shell has more space than the phage needs to store the DNA essential for its replication. This means that phages have room to carry extra genetic baggage: genes that are not actually necessary for the phages survival that it can modify at will.

To see how this plays out, lets take a deeper look at the phage life cycle.

Phages come in two main flavors: temperate and virulent. Virulent phages, like many other viruses, operate on an invade-replicate-kill program. They enter the cell, hijack its components, make copies of themselves and burst out.

Temperate phages, on the other hand, play the long game. They fuse their DNA with the cells and may lay dormant for years until something triggers their activation. Then they revert to virulent behavior: replicate and burst out.

Many temperate phages use DNA damage as their trigger. Its sort of a Houston, we have a problem signal. If the cells DNA is being damaged, that means the DNA of the resident phage is likely to go next, so the phage wisely decides to jump ship. The genes that direct phages to replicate and burst out are turned off unless DNA damage is detected.

Virulent phages follow the lytic cycle of viral reproduction, destroying their hosts as soon as they complete replication. Temperate phages, on the other hand, follow the lysogenic cycle and stay dormant inside their hosts DNA until theyre triggered to burst out. Credit: CNX OpenStax/Wikimedia Commons

Bacteria have retooled the mechanisms controlling that life cycle to generate a complex genetic system that my collaborators and I have been studying for over two decades.

Bacterial cells are also interested in knowing if their DNA is getting busted. If it is, they activate a set of genes that attempt to repair the DNA. This is known as the bacterial SOS response because, if it fails, the cell is toast. Bacteria orchestrate the SOS response using a switch-like protein that responds to DNA damage: It turns on if there is damage and stays off if there isnt.

Perhaps not surprisingly, bacterial and phage switches are evolutionarily related. This prompts the question: Who invented the switch, bacteria or viruses?

Our previous research and work by other researchers indicates that phages got there first. In our recent report, we discovered that the SOS response of Bacteroidetes, a group of bacteria that comprise up to a half of the bacteria living in your gut, is under control of a phage switch that was retooled to implement the bacterias own complex genetic programs. This suggests that bacterial SOS switches are in fact phage switches that got retooled eons ago.

When a temperate phage infects a bacterial cell and integrates its genome with the cells DNA, it typically lays dormant until its triggered to burst out of the cell. But once the phages DNA is part of the bacteriums, mutations can disrupt the phages genetic material and render it inactive. This means that when DNA damage occurs, the phage wont be able to reform itself and burst out. Over time, the bacterium may adapt the phages switch to control its own SOS response genes. Credit: Miquel Snchez-Osuna/Created with BioRender.com

Its not just bacterial switches that appear to be phage inventions. Beautiful detective work has shown that a bacterial gene needed for cell division also arose through domestication of a phage toxin gene. And many bacterial attack systems, such as toxins and the genetic guns used to inject them into cells, as well as the camouflage they use to evade the immune system, are known or suspected to have phage origins.

OK, you may think, phages are great, but the viruses that infect us are certainly not cool. Yet there is mounting evidence that the viruses that infect plants and animals are also a major source of genetic innovation in these organisms. Domesticated viral genes have been shown, for instance, to play a key role in the evolution of mammalian placentas and in keeping human skin moist.

Recent evidence suggests that even the nucleus of a cell, which houses DNA, could have also been a viral invention. Researchers have also speculated that the ancestors of todays viruses may have pioneered the use of DNA as the primary molecule for life. Not a small feat.

So while you may be used to thinking of viruses as the quintessential villains, they are arguably natures powerhouses for genetic innovation. Humans are likely here today because of them.

Written by Ivan Erill, Associate Professor of Biological Sciences, University of Maryland, Baltimore County.

Originally published on The Conversation.

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Viruses Are Both the Villains and Heroes of Life As We Know It Natures Powerhouses for Genetic Innovation - SciTechDaily

Coronavirus fact-check: Can the Pfizer vaccine affect a woman’s reproductive health? Myth debunked! – Times of India

CLAIMVaccine hesitancy and anti-vaccine claims are surging across the world, even as we get closer to having a COVID-19 vaccine ready. This has also affected one of the prime vaccine candidates we have right now, Pfizer, which has also applied for emergency authorization in India. Pfizer-BionTechs novel COVID-19 vaccine, BNT-162, which is one of the most promising vaccines approved for selective use right now has, too, been subjected to criticism and false claims, despite its strong safety and efficacy reports.

According to reports surfacing on social media pages, some users suggest that Pfizers vaccine could be bad for women of reproductive age.

The growing claims are raising concerns on the public level, as authorities draw up lists to inoculate the first doses amongst healthcare workers, senior citizens and hospital staff in the coming week.

A viral report, which cites Pfizers head of research suggests people to not take the vaccine jab, as it can cause female sterilization.

The social media post, which has been widely shared and circulated also offers a sort of explainer, adding that the vaccine works to deliver a robust immune response against a spike protein, 'synctin-1', which is vital for placental formation and once the vaccine is administered, it could cause sterilization and problems related to infertility.

The post reads:

"The vaccine contains a spike protein (see image) called syncytin-1, vital for the formation of human placenta in women. If the vaccine works so that we form an immune response AGAINST the spike protein, we are also training the female body to attack syncytin-1, which could lead to infertility in women of an unspecified duration."

The claim is similar to the one which suggested that the Oxford-Astrazeneca shot may be bad for males, and contains parts of human aborted fetus.

Related posts also suggests that some of the leading scientists and ex-heads of Pfizer have urged the medical community to draw COVID vaccination studies to an end because of significant safety concerns and threats to reproduction

TRUTHEven though the vaccine studies being conducted right now are happening in an accelerated, unprecedented manner, Pfizers vaccine jab is one of the earliest shots in the offering right now which carries a strong 94% efficacy rate.

Pfizer's vaccine, which is wrapping up phase III trials makes use of a novel mRNA approach, which trains the immune system to 'recognize' an illness-causing strain or germ.

The vaccine, which has been widely tested on 30,000 + volunteers (both healthy and young) hasnt been observed to carry adverse reactions or side-effects which could impact its functioning.

Also, most trials are being regulated under the purview of the World Health Organisation (WHO) and subject to stringent norms. None of the trials differentiate between male and female volunteers. Hence, the odds of any vaccine being bad for just one sex would be a tall claim to make.

Secondly, as of right now, none of the volunteers who have spoken up about the vaccine trials have reported suffering from mysterious side-effects such as the one being reported on social media.

VERDICT

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Coronavirus fact-check: Can the Pfizer vaccine affect a woman's reproductive health? Myth debunked! - Times of India

Another wedding season in Nepal: Why too few dates for too many couples every year? – Online Khabar (English)

Mangsirthe eighth month of the Nepali calendar system has two major connotations. For farmers of the country, this is the harvest season. For marriageable young men and women, however, this is the time to find their life partners or to tie conjugal knots with their loved ones.

Generally, four months, before Mangsir, are not considered auspicious for the wedding in the traditional Hindu astrology whereas the next month is also not a favourite. This years case is even harder; if any couple misses the chance of Mangsir, they will have to wait until Baishakh (mid-April to mid-May 2021) to find an auspicious date. Therefore, it is likely that you might have several wedding receptions to attend this Mangsir.

But, why is that?

We have some helpful information for you.

Astrologer Basudev Krishna Shastri says it is important for a wedding to happen on a holy date because it is one of the 16th samskaras (rites of passage) as per Hindu Vedic traditions.

Marriage is related to the continuation of human species in this world, he explains, The Vedic tradition, hence, considers a wedding as the combination of two souls that should be united with the blessings of all the gods and goddess from all four directions, the sun, the moon and the stars.

And because fire is also considered a god as well as an agent via which all other gods receive offerings given by humans, it is important that one weds beside a fire on an auspicious date, according to him.

The traditional calendar system divides a year into two halves, called Uttarayana and Dakshinayana. According to astrologer Laxmi Prasad Baral, most weddings take place in Uttarayana (Magh to Asaar or mid-January to mid-July). During these months, the sun travels to north from south in the celestial sphere, he says, But, Chaitra (mid-March to mid-April) is an exception when weddings cannot be scheduled.

The Yamalok lies in the south where the god of death, Yama, lives. Basically, the south is known as the direction of pitris (ancestors) and the north is of gods and goddesses, adds Baral, Therefore, the weddings in the Dakshinayana (when the sun travels towards the south from the north) are not considered good. But again, there is also an exception of Mangsir (mid-November to mid-December).

For him, the practice of performing weddings in the Mangsir month (one of the months of Dakshinayana) was lately developed considering that Lord Vishnu had also awoken from his four-month sleep by this time, describes Baral.

Shastri says astrologers calculate good dates for a wedding after studying the movement and positions of the sun, the moon and other planets in the solar system, mainly, Jupiter and Venus. Likewise, the five elements of time (Panchanga)tithi, nakshatra, yog, bar, and karanare also considered.

Among nine planets recognised in the traditional astrology, positions of Jupiter and Venus are important in fixing a wedding date. Jupiter is the guru of all gods whereas Venus has a role in reproduction, Shastri explains One can wed only when both Jupiter and Venus are on the rise (udaya).

The months of Magh and Phalgun this time (mid-January to mid-March 2021) do not have any wedding date. Jupiter will set on the western direction on January 17 and Venus will set on the eastern direction on February 12, Shastri informs, Jupiter will rise back on February 14, but Venus will be set beyond mid-March.

Meanwhile, Surya Prasad Dhungel, the member-secretary of Nepal Panchanga Nirnayak Samiti, the government authority assigned to decide festival dates and auspicious times, adds, There are only 11 (out of 27) nakshatras ideal for weddings. Hindu scriptures have also clearly mentioned the ideal tithis and months for weddings and other occasions. Also, weddings cannot be held during a malamaas or kshayamaas.

Understanding an exact calculation requires a deep study of astrology and a long time, Dhungel says, adding the avid learner consults astrological masterpieces such as Muhurta Chintamani while calculating wedding dates.

Because there are a few selected dates for weddings in a period, finding a space for wedding receptions on and around those dates is a real hurdle for residents of crowded cities such as Kathmandu. Moreover, families find it difficult to attend multiple parties on a single day.

That is why, nowadays, there are many who do not wait for the auspicious dates to get married. Likewise, people have begun considering weddings on other festivals such as Akshaya Tritiya, Bibaha Panchami, Krishna Janmashtami, and Navaratri as auspicious too.

But, Baral highlights weddings cannot take place on Krishna Janmashtami or Navaratri as Lord Vishnu, the main god of yagyas who grant the worshippers the fruit of yagyas, is asleep this time.

Moreover, Shastri finds the trend of defying set dates and marrying on other dates completely wrong and comments, If the wedding is to be performed as per Vedic tradition, the couples have to wait for an auspicious date. If not, there will negative consequences on their marital life. Also, there will be difficulty in reproduction; their child might be born with several disabilities.

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Another wedding season in Nepal: Why too few dates for too many couples every year? - Online Khabar (English)

Spinal motoneurons of the human newborn are highly synchronized during leg movements – Science Advances

Motoneurons of neonatal rodents show synchronous activity that modulates the development of the neuromuscular system. However, the characteristics of the activity of human neonatal motoneurons are largely unknown. Using a noninvasive neural interface, we identified the discharge timings of individual spinal motoneurons in human newborns. We found highly synchronized activities of motoneurons of the tibialis anterior muscle, which were associated with fast leg movements. Although neonates motor units exhibited discharge rates similar to those of adults, their synchronization was significantly greater than in adults. Moreover, neonatal motor units showed coherent oscillations in the delta band, which is directly translated into force generation. These results suggest that motoneuron synchronization in human neonates might be an important mechanism for controlling fast limb movements, such as those of primitive reflexes. In addition to help revealing mechanisms of development, the proposed neural interface might monitor children at risk of developing motor disorders.

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Spinal motoneurons of the human newborn are highly synchronized during leg movements - Science Advances