Human reproductive technologies like sperm freezing and IVF could be used to save threatened species – The Conversation AU

More and more threatened species are relying on captive breeding to avoid extinction. Some species on the brink only exist in captivity, and others depend on captive breeding for their recovery before theyre released to the wild.

Captive breeding programs face major challenges to achieve the best conservation outcomes, particularly high economic costs, and loss of vital genetic diversity from wild populations after even a few generations in captivity.

Our economic and genetic modelling published today shows how freezing genetic material and using assisted reproduction could provide a much-needed support-tool for captive breeding programs, solving genetic and economic issues and allowing zoos to breed more species and expand their valuable work.

These are the same tools and technologies commonly used in animal agriculture, research, medicine and disease and human fertility to boost production, lower costs, and produce healthy and strong humans and animals.

No-one should doubt the value of captive breeding to conservation. The European bison, California condor and Australias Southern Corrobboree Frog are three iconic species which would be extinct without captive breeding. Iconic Australian species the Orange-bellied Parrot and greater bilby have been captive bred for over 30 years.

Captive breeding is expensive in resources, labour and capital. Programs have high start-up costs, in the hundreds of thousands or even millions of dollars. High annual on-going costs, on average, are over $200,000 per year for a single species. Many programs are open-ended and will be required for many years or even decades if they are to achieve their objectives.

The high costs of current programs prevent conservationists from assisting many species that desperately need captive breeding. Amphibians are a case in point. Disease and habitat loss is decimating wild amphibian populations globally. There are now over 900 amphibian species which need captive populations. Over 200 of these species need it urgently to avoid extinction. Despite hundreds of species in need, the estimated global capacity and available resources can provide captive populations for no more than 50 amphibian species.

Read more: Swingers' hookup program can find the right match for endangered species

The costs are one thing, the genetics are something else. Captive breeding programs face significant challenges with genetic diversity. These are common even in some of the longest running and well-resourced captive breeding programs, such as giant pandas and Tasmanian devils.

Genes are lost after even one generation of captive breeding, and in just a few generations, animals most likely to thrive and breed in captivity show traits of domestication and adaptation to captivity. Inbreeding depression is unavoidable in small captive colonies typical of some captive programs. The loss of wild genes affects the overall fitness of captive bred animals for release back to the wild.

To counter the loss of genes in captive populations, the common global target for captive programs is to maintain 90% of the original captive populations genetic diversity for one hundred years. This is considered gold standard practice and aims to ensure reintroductions of animals into the wild long in the future will occur using animals with minimal genetic issues.

This target is unachievable in most programs because it is not feasible to keep colonies large enough to reduce inbreeding rates to the level required. But using biobanking and existing or developing assisted reproductive technologies could solve genetic and cost issues and finally make this target achievable.

Biobanking is the frozen storage of various living cells from threatened species, particularly sex cells, including sperm, eggs and embryos. Frozen samples can be kept long-term as insurance against extinction or thawed for use in conservation genetic management.

Read more: Tasmanian devils reared in captivity show they can thrive in the wild

Biobanking is not uncommon. Large commercial biomedical biobanks routinely store cell lines for cancer and other medical research. Biobanking is used extensively to store seeds of crops and threatened plants and in animal agriculture to store rare or valuable breeds of livestock animals.

Biobanks exist for conservation also, for example the Frozen Zoo in San Diego, the UKs Frozen Ark and the Australian Frozen Zoo store frozen samples of some of the worlds most threatened species. Biobanking is helping save the black-footed ferret from extinction after the last remaining ferrets (less than twenty) were brought into a captive breeding program in the 1980s and supplemented with frozen sperm after many years to add back lost genes.

Using real data on the economic costs of captive breeding, we generated models for the threatened Oregon spotted frog (Rana pretiosa), a native of Canada and North America, which predict program costs and rates of genetic diversity loss for captive populations of any size. We then calculated how these costs change, and inbreeding rates reduce, when genes are added back into captive populations each generation using cryopreserved sperm. These models will work on any species where costs of captive breeding are available.

Read more: Personality matters: when saving animals, fortune favours the bold

The results for the Oregon spotted frog model were startling. Biobanking dramatically slowed the rate of inbreeding and required far fewer live frogs to be held. Under normal captive breeding conditions, over 1,800 live frogs were required to meet the genetic target. By using biobanking, this number was reduced to 58 live frogs.

The estimated cost savings and the improved genetic fitness for the Oregon spotted frog were profound. The conventional captive population required to meet the genetic target of 90% genetic diversity would cost over $2.8 million to set up, followed by $537 million in a total 100-year program. The biobanked population would cost $121,000 to set up, followed by total costs of only around $20 million over the same period. This represents a 26-fold reduction in overall costs from normal captive breeding to the biobanking approach.

Investment in the biobanking approach could allow captive breeding institutions to maintain animals that are fitter and more like those from wild populations. Captive breeding programs could meet genetic targets which have never been achieved and produce animals more suited for release to the wild.

The drastically reduced costs would allow institutions to hold many more species. With investment in research on the underlying technologies, the approach would not be limited to amphibians and could work in any species. Building in biobanking could usher in a new era of captive breeding for a much greater number of species in desperate need.

Read more: Zoos aren't Victorian-era throwbacks: they're important in saving species

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Human reproductive technologies like sperm freezing and IVF could be used to save threatened species - The Conversation AU

16 Days of Activism What have our Members been up to? – International Federation of Gynecology and Obstetrics

Today marks the end of the official 16 Days of Activism against Gender-Based Violence, which falls on International Human Rights Day. This years theme was Orange the World: Fund, Respond, Prevent, Collect! We spoke to some of our Members of the Human Rights, Refugees and Violence Against Women Committee about the activities they carried out to ensure that awareness around the theme of the 16 Days was increased and to increase commitment to the elimination of this tragedy.

Dr Diana M. Galimberti from Argentina, tells us how, alongside colleagues, they committed to addressing violence against women in Latin America.

Dr. Miguel Gutirrez Ramos and I committed to address the topic of sexual abuse and violence throughout Latin America when in Istanbul.Although in El Salvador, Guatemala and Argentina we received immediate support for our activities, the worldwide quarantine impeded continuation of this project until mid- 2021.However, Dr. Gutirrez has actively participated in several meetings that were nevertheless held: at the University of Santa Fe in October of this year, where I acted as coordinator;once at a nation-wide course for obstetricians in Peru, and he will be a speaker at a meeting on sexual and reproductive rights in Arequipa, Per shortly.He habitually represents the topic of GBV from FIGO perspective at the professional meetings he attends.

During times of war, general disruption of the normal way of life conduces to higher levels of violence in society.

Argentinais one of the most advanced countries in facing GBV against women and girls.Social programmes, judicial backing and general campaigns are forwarded by the Ministry of Health and also the Ministry of Justice and Human Rights. A federal survey for all health workers has recently been launched and, based on its results, training programs on GBV will beinstituted in all public hospitals of the country.

Dr Chiara Benedetto, Chair of the FIGO Subcommittee for Refugees, explains the current situation in Italy and what they are doing to advocate for an end to violence against women.

Winning rights for girls and women is about more than giving opportunities, it is also about changing how countries and communities work, and how the fabric of society evolves. It means investing in a fairer, more equal society, free from violence. Indeed, we are living through a trying time where Gender Based Violence (GBV) is ever more behind locked doors as the waves of the COVID Pandemic confine victims with perpetrators. In Italy, there were 91 feminicides in the first 10 months of 2020, i.e., 1 every 3 days and a 73% increase in requests for help to the various associations (Istat -TheItalian National Institute of Statistics).

In line with FIGOs declarations on Violence Against Women, we recognisethat violence against women and against girls is highly prevalent and may be exacerbated in situations of crises such as conflict, displacement and among refugees. Indeed, we are in constant contact with our migrant focus group members, also through emergency numbers and assistance. Despite the COVID Pandemic and the heavy restrictions on meetings/congresses in person, numerous initiatives have been, and will be taken in Italy to raise awareness as to GBV, including a webinar, video appeals, and a number of online meetings and initiatives.

Dr Colleen McNicholas from the United States comments on their situation and what we need to do to centre the most vulnerable.

The United States continues to provide example after example of why the work of addressing and eliminating human rights violations, especially acts committed against minority communities, is so important. The devastating revelation of forced hysterectomies and sterilisation on migrant detainees reawakened an awareness of the shameful history this country has of prioritising the fertility and reproduction of some while decimating others. When I think of the most impacted by violence against women, I cant help but acknowledge the horrific rates of murder amongst transgender women, particularly women of colour. If raising awareness about gender-based violence is to have a meaningful impact, we must centre the most vulnerable.

From Mexico, Dr Atziri Ramirez tells us about online support groups for victims of violence.

I have committed myself to an online facebookgroup called "Feminist Doctors" where we touch upon several topics one of them regarding "how to educate and disseminate the Violentometer" which is a scale where a woman can realise that she is being a subject of violence. We have concluded that a good way is by posting this information in groups and offering access to public resources (such as public telephone numbers of agencies that are supporting women who are victims of violence in their homes). Following the line of online content I also became part of a group called "Trueka Feminist" which supports victims of violence by online trade. I have disseminated this information among my peers,undergraduatestudents and trainees.

Finally, Dr Taghreed Alhaidari shared posters that were created by the Iraq Member Society which were published on social media, highlighting facts and figures on the rates of GBV.

We hope these examples inspireyou to continue to carry out this important advocacy work and help to eliminate violence against women, beyond the 16 Days of Activism. For more resources on GBV and the 16 Days, visit the UN website.

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16 Days of Activism What have our Members been up to? - International Federation of Gynecology and Obstetrics

Dead mans sperm off limits: B.C. court – Vancouver Is Awesome

A widow hoping to have another child with her late husband was denied her appeal.

B.C.'s Court of Appeal has ruled against a widow seeking to have a child using sperm from her dead husband's body.

Not long before his death, a couple referred to by the court as Mr. and Ms. T had a child, the unanimous ruling of three BC Court of Appeal judges said. They had been in a long-term relationship and married for three years before his death.

Mr. T died October 2, 2018. Ms.T contacted a fertility centre the next day about retrieving Mr.Ts sperm for future reproductive use. She was told such a retrieval should occur within 36 hours of death and needed a court order.

So, on October3, 2018, an urgent after-hours application was brought before BC Supreme Court Justice David Masuhara seeking orders to remove and store Mr. Ts reproductive material.

Masuhara authorized the removal by a qualified physician and ordered it be stored at the identified fertility centre. He further stipulated it could not be released, distributed or used until further order of the court.

However, Mr. T had not given his consent for post-mortem removal of his sperm prior to his death.

However, people close to Mr.T testified he wished to have more children, that his child have siblings.

The federal Assisted Human Reproduction Act and regulations prohibit the removal of human reproductive material from a donor without the donors prior, informed, written consent.

So, Masuhara ruled in December 2019, our policy makers require an individual to formalize their informed consent in writing if she or he wishes to permit the posthumous removal of their reproductive material. Regrettably, that is not the case here.

He ordered the sperm destroyed but stayed the order for an appeal.

However, on November 24, appeal court Justice David Harris said, I would dismiss the appeal. I do so with regret, aware of the painful and tragic circumstances confronting Ms.Ts family.

Harris said the legislation is a clear and unequivocal prohibition on removal of reproductive material to create an embryo unless the donor (here Mr.T) has given written consent for that use in accordance with the regulations (which he had not).

Further, Harris said, I cannot agree that the prohibition is only intended to apply in the case of a foreseeable death and not an unanticipated one where a couple are planning to have children together. To read the statute in that way would be to amend it by judicial decree. We have no right to do so.

Harris also dismissed the suggestion that Masuharas interim order permitting the removal of Mr.Ts reproductive material has created property that she was entitled to possess.

Her potential claim to have such a right would have been lost without the order, Harris said.

However, Harris stayed his order for 60 days to permit the possibility if an appeal to the Supreme Court of Canada.

jhainsworth@glaciermedia.ca

@jhainswo

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Dead mans sperm off limits: B.C. court - Vancouver Is Awesome

Joe Mathews: The number of COVID-19 deaths in the US would fill Forest Lawn Memorial Park by January – KCRW

The numbers keep going higher and higher. California reported more than 11 thousand new COVID-19 cases Wednesday--bringing the states total so far to just over one (m)million. And nationwide we have surpassed a quarter million deaths.

That is an impossibly large number to comprehend. Thats why in this edition of Zocalos Connecting California, commentator Joe Mathews took a trip to Forest Lawn Memorial Park, where 340,000 bodies are laid to rest. The United States is projected to reach 340,000 recorded COVID deaths by January.

Read Mathews column below:

If youre having a hard time processing the scale of death produced by the COVID-19 pandemic, heres a California alternative for wrapping your mind around the carnage:

Visit the largest, prettiest cemetery you can find. I recommend the original Forest Lawn, in Glendale, the most Californian of cemeteries.

I recently walked the 290 acres of this memorial park, the first of six Forest Lawn parks in Southern California, and found that it clarified my thinking and improved my mood.

It also helped me to put in perspective the full human toll of COVID-19. Since Forest Lawn opened here 114 years ago, in 1906, it has interred 340,000 souls on this property. Under current projections, the U.S. will reach 340,000 COVID deaths in January.

Such statistics reflect a fundamental human failure: We experience individual death intensely (be it a friends death or the killing of George Floyd), but struggle to recognize death in the aggregate. This myopia is why we need cemeteries right now.

Cemeteries are not just a place to reflect on the past, wrote longtime Forest Lawn chief executive John Llewelyn, in A Cemetery Should Be Forever. They remind us to keep the present in perspective.

Especially when the present is so frightening.

Forest Lawns mission was about putting a sunny California spin on death.

I believe in a happy eternal life, Forest Lawns first real leader Hubert Eaton wrote in 1917. I therefore know the cemeteries of today are wrong, because they depict an end, not a beginning I shall try to build at Forest Lawn a Great Park filled with towering trees, sweeping lawns, splashing fountains, singing birds, beautiful statuary, cheerful flowers, noble memorial architecture with interiors full of light and color, and redolent of the worlds best history and romances.

The resulting memorial-park has been critiqued as a Disneyland of Death. But at this moment, I found visiting the happiest cemetery on Earth soothing, and thought-provoking.

I encountered joggers, bikers, painters, and babies in strollers. I heard birds sing as I enjoyed 360-degree L.A. views from the esplanade. A half-dozen people chatted amiably while admiring The Mystery of Life, a sculpture group of 18 human figures gathered at stream that flows toward an unknown destination.

By its usual standards, Forest Lawn was pretty quiet. Its art museumwhich houses an important collection of stained glass and William Bouguereaus 1881 painting Song of the Angelswas closed. There were no school field trips on the grounds. Tens of thousands of people, including Ronald Reagan, have been married at Forest Lawn, but during my visit there were no weddings in the cemeterys three churches, which were locked.

Still, I enjoyed the way the place resembles Southern California in miniature, with its varied topographies (hills, valleys, a sprawling basin), and obsession with being big (Forest Lawns wrought-iron gates are twice as wide as those at Buckingham Palace).

In.an older, flatter cemetery section I walked amidst the century-old graves of people who died in their 20s of Spanish flu. In the Court of Freedom, I admired a giant outdoor reproduction of John Trumbulls Signing of the Declaration of Independence and reflected on Jeffersons wisdom in putting life before liberty and pursuit of happiness.

This pandemic is killing so fast that were not stopping to appreciate the lives lost. We will need to remember the plagues lessons, to honor its sacrifices, so we might see its after-life as a beginning, not an end.

Here in California, we should memorialize every last one of our pandemic dead, with a monument that is beautiful and big, and makes people happy when they visit it.

Joe Mathews writes the Connecting California column for Zcalo Public Square.

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Joe Mathews: The number of COVID-19 deaths in the US would fill Forest Lawn Memorial Park by January - KCRW

Embryology: Understanding the science and the scientists behind a successful IVF procedure – Economic Times

In the success rates of IVFs or any assisted reproduction procedure, the role of Embryologists is often underrated. Most of the people are unaware of their very presence behind their journey towards achieving parenthood. Despite this ignorance, we should not overlook the fact that these embryologists are essentially scientists, who play a crucial role in the successful conception of babies through advanced assisted reproductive technologies.

An embryologist is nothing short of a scientist, who helps to create viable embryos to either be used in IVF treatment or while embryo freezing. The responsibilities of embryologist involve prudently managing and maintaining the genetic fabric used in creating embryos. They also take care of the development of the embryos closely. This requires deep understanding of the science behind nurturing eggs, sperm and embryos outside human body clinical methods and technological backup to ensure success rates. With the rising incidents of infertility globally approximately 1 in 7 of reproductive age being diagnosed as infertile the role of embryologist has also been intensified over the years. Globally, every year over five million ART babies are born through ART treatment.

If we talk about India, the IVF industry is expected to grow at a compound annual growth rate (CAGR) of 28 per cent, and is assumed to be around USD 775 million (Rs 495 crore) by 2022.

Comprehending the role of embryologist

Before learning about embryologist, its imperative to understand the whole IVF process. It starts from extracting the eggs, retrieving sperm sample, and then fertilizing them manually by injecting sperm into an egg in the laboratory on a dish. The embryo is then transferred into the uterus. After the retrieval of eggs, the eggs are handed over to a team of highly trained embryologists that perform these procedures in a sophisticated and well-controlled environment

Embryologists are the experts of Clinical Embryology, a branch of biology concerned with the study of fertilization of eggs and development of embryos. They are the scientists who help to create embryos outside the womb using sperms and eggs.

Future of embryologists

As more and more couples are now going for IVF when they are unable to conceive naturally, it shows there is an increase in the demand for ART treatments. This also indicates that there will be a demand for trained embryologists. The surplus of embryologist demand will also call for the requirement of intense knowledge in application of emerging technologies in the near future as technology is no doubt ruling the IVF industry.

An embryologist can be employed by assisted reproductive clinics in government as well as private hospitals. Gradually, one can also be given more responsible positions as Lab manager or Lab director. But embryologist is such a job which needs rigorous training in laboratory skills, management and be updated about the latest technologies. Seeing the trend, many educational institutions have introduced embryology courses in their module. One can also join these institutes after completion of their course as faculty of embryologist.

DISCLAIMER : Views expressed above are the author's own.

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Embryology: Understanding the science and the scientists behind a successful IVF procedure - Economic Times

Explainer: The Allegations Against Akshaya Patra, and Why a Probe Is Needed – The Wire

News of the Akshaya Patra Foundations (APFs) independent trustees resigning, which was in the air for over a month, thrust itself into the public domain when the Deepavali crackers were being burst. Why it took such a long time to be confirmed by both parties the missionary and independent members we will see a little later. But first, let us explore the nature of the controversy that had enveloped the APF until the independent trustees resigned, and why that had a moral bearing on all those involved in running the APF.

The controversy with regard to the APF, until recently, had to do with their diet, which excluded onion and garlic. The fact that they also refused to serve eggs to children had gone against the science of nutrition. It was seen as the intransigent ideological position of ISKCON-Bangalore, which reflected upper-caste food values in India.

The ISKCON-Bangalore, as an independent private entity, was free to pursue its faith, but sadly the APF, which it hosted, was portrayed as independent of ISKCON-Bangalore right from its inception around 2000. It received public and private donations with this particular appeal, and importantly, became the agency of many state governments to implement the midday meal welfare programme. Currently, 14 state governments and the Government of Indias Ministry of Human Resources Development are partnering with the APF to serve around 19,000 schools across the country.

Also read: The Egg Debate Boils Over Will Governments Stop Playing With Childrens Food?

By perusing the names on its board of trustees, advisors and donors, one can see how the APF, over two decades, became a cherished hub where missionaries met corporates and influenced bureaucrats and politicians to hand over the governments midday meal programme. Till the ISKCON-corporate partnership happened, midday meal scheme had an autonomous community structure, and still does in many places where the APF does not reach.

It was obvious to anybody looking that in the new arrangement, faith mingled with philanthropy in a not-so-subtle way. Since this was about meals to underprivileged children, and since the APF aggressively advertised hygienic kitchens, a corruption-free milieu, a hassle-free delivery system and happy faces of kids, many were reluctant to question the intermingling of faith and philanthropy that was explicitly supported by public funds. The impression that the APF gave until recently was that it was a well-run foundation with professional expertise that came from the very cream of Indian corporates. Gradually, over the years, the reinforcement of APFs branding was such that it became an ISCKON-Bangalore programme and not one heavily subsidised by governments. There was very little effort to correct this perception by government officials or politicians.

The legitimacy that was constructed for the APF with big names like N.R. Narayana Murthy, Gururaj Desh Deshpande, Dr Devi Shetty, Deepak Chopra and others made it difficult for the media to question the group. Whenever they did, there would be enormous pressure to either retrace the opinion or abort follow up questions. Paradoxically, after all this image management in two decades, the independent trustees T.V. Mohandas Pai, Raj P. Kondur, V. Balakrishnan and Abhay Jain have now issued statements which suggest that the APF has serious governance issues and has also had to contend with wrongdoings and whistle-blower complaints.

Mohandas Pai. Photo: PTI

The outgoing trustees, who did not have qualms when ISKCON-Bangalore was imposing its skewed diet plan on unsuspecting, needy children, are ironically speaking out loud now on the APF as an independent charity that has to cede greater control to independent trustees. Why is it being belatedly emphasised that the APF is a custodian of public money, and that there has to be greater transparency? It is surprising that for two decades when ISKCON-Bangalore and APF were drawing strength from each other, there was no talk of related-party transactions and quid pro quo, both literally and metaphorically speaking. The books were perhaps kept clean and separate, but there was a moral poser continuously hanging over the trustees, donors and governments on the diet. If there was a pact and a compromise between the missionaries and independents trustees on the APF board for two decades, why has it been broken now? What has caused this rupture?

An over 3,500-word letter that a member of APFs internal audit committee wrote to the trustees a few weeks ago (his name is being withheld on the request of The Wires source) has the following paragraphs that raise issues that are alarming. Here is a verbatim reproduction of some passages from the letter:

Also read: Private Sector Ideas on Nutrition Should Be Taken with a Pinch of Fortified Salt

At the end, the internal audit committee member concludes that a comprehensive forensic investigation may be necessary. The Wire has not independently verified the veracity of the charges made in the letter. After the committee offered its opinion on the lines illustrated above, it is alleged that the missionaries sought an opinion from a retired judge of the Supreme Court on the other board affiliations of Suresh Senapaty, one of the audit committee members. These enquiries were unrelated to the APF. This was apparently used as moral leverage to get him to quit the committee. This was one of the triggers for the independent trustees to get behind their corporate colleague.

After the missionary trustees reconstituted the APF on November 14, 2020, a prominent outgoing trustee wrote an angry, hard-hitting, yet a revealing mail [his name is again being withheld on request from the source] to the missionary trustees. Here are a few verbatim extracts from the letter:

The Wire has not been able to independently verify the allegations made in this letter either. Another outgoing trustee agreed with the internal audit panel report, cited a November 9, 2020 letter written by yet another independent trustee, and wrote: I do hope and pray that you get your full comeuppance soon. And more importantly, I hope these issues get investigated by credible parties to reveal the full extent of the rot over which you have presided, and the work of Akshaya Patra saved from your greedy clutches.

Among the independent trustees, Abhay Jain resigned in February 2020 citing governance issues, but interestingly none of his colleagues stood up for him at that point, although they had journeyed together for two decades. The matter heated up only subsequently, and according to one source the independent trustees never intended to resign, but it could be a case of their brinkmanship having gone terribly bad. In fact, when the controversy began, the chairman of the APF, Madhu Pandit Dasa, made a fervent appeal to one of the independent trustees on October 18, 2020. Here are verbatim extracts from Dasas letter:

Given the nature of the allegations, and the fact that public funds are involved, perhaps only a multi-agency probe may offer clarity and truth. The invocation of the divine to deliver justice, as we have seen in the letters of both missionaries and independents, can wait until the probe is completed. Or, it could happen simultaneously as one has no control over it.

Sugata Srinivasaraju is a senior journalist, author and columnist.

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Explainer: The Allegations Against Akshaya Patra, and Why a Probe Is Needed - The Wire

Third Committee Approves 11 Drafts, among Them 4 Covering Women’s Rights, Omnibus Text on High Commissioner for Refugees Report, as Myriad Amendments…

GA/SHC/4310

In a day of intense action, the Third Committee (Social, Humanitarian and Cultural) approved 11 draft resolutions, including 4 on the broad theme of the advancement of women, which touched on the special needs of women and girls living in conflict-affected areas, complex humanitarian emergencies and terrorism.

Among them was a draft approved by a recorded vote of 170 in favour to none against, with 11 abstentions on preventing and eliminating all forms of violence against women and girls. By its terms, the Assembly would urge States to take effective action to eliminate all such violence and to address structural and underlying causes and risk factors.

Its passage weathered unyielding attempts to pass seven draft amendments, proposed by the Russian Federation, and three proposed by the United States, to address wording concerns. Each of the measures failed in recorded votes.

The representative of the Netherlands, presenting the draft resolution, highlighted the dramatic increase in violence against women and girls during the COVID19 pandemic. The draft expresses an unambiguous condemnation of violence, and presents a global compromise, based on agreed language. We all had to compromise, he said, rejecting the proposed amendments as hostile. Echoing those concerns, the United Kingdoms representative rejected the amendments, several of which sought to weaken language on sexual and reproductive rights. South Africas delegate likewise said the proposed amendments contradict the principle of multilateralism. Terms, such as sexual and reproductive health, were agreed upon in the 1990s. Meanwhile, Egypts representative expressed support for amendment L.59, stressing that the concept of intimate partner violence remains unclear and lacks an internationally agreed definition.

In other action, the Committee approved its omnibus draft resolution on the report of the Office of the United Nations High Commissioner for Refugees (UNHCR), by a recorded vote of 174 in favour to none against, with 7 abstentions (Cameroon, Eritrea, Hungary, Iran, Libya, Poland, Syria). By its terms, the Assembly would urge States to uphold the civilian and humanitarian character of refugee camps and settlements. It would also call on those that have not yet contributed to burden- and responsibility-sharing to do so, with a view to broadening the support base.

Several delegates, including from the United Kingdom and Portugal, on behalf of a group of countries, expressed regret over the call for a vote on a purely humanitarian text. Norways representative, presenting the text on behalf of the Nordic countries, said it represents a technical rollover of the one approved in 2019. Due to COVID19, and following the Third Committee bureaus guidance, no substantial negotiations were held.

Syrias delegate, however, called for a vote, explaining that his delegation would abstain, as amendments to the drafts substance submitted by Syria and Iran were never entertained. Syria had suggested negotiating in New York on several occasions in hopes of reaching a balanced text. There was no response to our calls, he stressed.

More broadly, the Committee approved several drafts without a vote, among them a draft on literacy, by which the Assembly would urge Governments to cooperate in ensuring that sufficient funds are channelled through existing international financing mechanisms for education including during the COVID19 pandemic and that they also explicitly target and benefit youth and adult literacy.

Among other drafts approved by consensus was one on human rights and extreme poverty, by which the Assembly would call on Member States to design COVID19 recovery strategies and implement gender-responsive social protection and fiscal policies that promote gender equality.

Also approved today were draft resolutions on: trafficking in women and girls; child, early and forced marriage; the human rights treaty body system; the world drug problem; obstetric fistula; female genital mutilation; and protecting children from bullying.

The Committee will reconvene at 10 a.m. on Tuesday, 17 November, to continue its work.

Action

Launching the day, the Committee took up the draft resolution titled Trafficking in women and girls (document A/C.3/75/L.14).

The representative of the Philippines, presenting the draft resolution, said human trafficking robs women and girls of their dignity in the most heinous way, which is why the Philippines applies the full force of law against human traffickers. Her country added a new paragraph on the impact of COVID19 on human trafficking. Online sexual exploitation has significantly increased as a result of lockdowns and restrictions imposed by authorities. However, considering the many challenges of the online platform of the meetings, the Philippines decided to introduce only technical and minor updates to the resolution. She expressed regret over the amendment to operative paragraph 31, which reflects agreed and delicately crafted language. References to sexual and reproductive healthcare services do not necessarily include abortion, she stressed, calling for a victim-centred approach.

The representative of the United States presented amendment L.68, which would delete the words including sexual and reproductive healthcare services from operative paragraph 31.

The representative of Germany, speaking on behalf of the European Union, objected to the amendment, stressing that the reference to sexual and reproductive healthcare services is based on long-agreed language and that trafficking of women and girls has increased during the COVID19 pandemic. The European Union will vote against this amendment, he said, urging all States to do the same.

The representative of Argentina, on behalf of a cross-regional group of countries, expressed surprise over the proposed amendments, as they seek to modify agreed language that stems from the 1994 International Conference on Population and Development. She called for universal access to healthcare services, expressing regret that delegations are forced to vote on this issue and urging Member States to vote against the amendment.

The Committee then rejected draft amendment L.68, by a recorded vote of 120 against to 9 in favour (Libya, Nauru, Palau, Qatar, Russian Federation, Sudan, Syria, Tonga, United States), with 28 abstentions.

The representative of Hungary, stressing the importance of protecting victims and prosecuting perpetrators, disassociated from preambular paragraph 10, underscoring that the causes of migration should be addressed nationally.

The representative of the United States called for an effective implementation of the Protocol to Prevent, Suppress and Punish Trafficking in Persons, Especially Women and Children, supplementing the United Nations Convention against Transnational Organized Crime. Traffickers have exploited COVID19 restrictions for profit, he said, highlighting the vulnerability of women and girls during the pandemic. He disassociated from operative paragraph 31 of the draft resolution as the United States cannot accept references to sexual and reproduction health and healthcare services or any similar language that would promote abortion or recognize the right to abortion. We do not recognize abortion as a method of family planning, he said, noting that there is no international right to abortion. Regarding references to the 2030 Agenda for Sustainable Development and the International Criminal Court, he referred to the United States statement delivered on 13 November, stressing that the United States disassociates from preambular paragraph 10 and does not accept the Global Compact for Safe, Orderly and Regular Migration and objects to such references in the draft. He also opposed the term child prostitution and called for its substitution with the term child trafficking.

The Committee approved the draft resolution on Trafficking in women and girls. By its terms, the Assembly would urge States that have not yet done so to consider ratifying or acceding to the United Nations Convention against Transnational Organized Crime and the Protocol to Prevent, Suppress and Punish Trafficking in Persons, Especially Women and Children.

Among other terms, the Assembly would call on Governments to intensify their efforts to prevent and address, with a view to eliminating, the demand that fosters the trafficking of women and girls, and to put in place or to enhance preventive measures including legislative and punitive measures to deter exploiters of trafficked persons, as well as to ensure their accountability.

The representative of the Russian Federation said she was not convinced that the International Criminal Court represents the appropriate instrument for exercising justice, even if the crimes stipulated in the draft resolution could hypothetically fall under its jurisdiction. The Court must restore its own authority and refrain from a policy of double standards and politicized investigations, he stressed, rejecting the wording in preambular paragraph 16 about the Rome Statute and disassociating from consensus on this paragraph.

The representative of Qatar said her country views operative paragraph 31 from the perspective of national laws and in accordance with its traditions.

The representative of Iraq disassociated from preambular paragraph 16.

The Committee then took up the draft resolution titled Child, early and forced marriage (document A/C.3/75/L.18/Rev.1), which contained no programme budget implications.

The representative of Zambia, introducing the draft, said child, early and forced marriage constituted a grave abuse of human rights. Unfortunately, COVID19 has impeded progress towards eliminating this problem, he said, citing an extremely concerning finding in a report by the United Nations Population Fund (UNFPA), suggesting that the socioeconomic impact of the pandemic would likely generate 13 million additional cases of forced marriage by 2030. We cant afford to see hard-won progress set back, he said. The draft proposed by Zambia and Canada has the support of a cross-regional group of countries, and is a strong, balanced text reached through extensive, transparent negotiations. It contains language concerning the impact of the pandemic on efforts to end harmful practices affecting children, particularly girls, as well as proposals to eliminate such behaviour. Negotiations took place in a collegial manner. Therefore, we are disappointed that some delegations decided to table amendments, which compromises the integrity of principles underlying negotiations, he said, urging that the draft be approved by consensus.

The representative of the Russian Federation, introducing amendments L.77 through L.83, said she is disappointed by the reluctance of those who drafted the text to consider her delegations numerous concerns, thereby forcing her to submit several amendments.

On amendment L.77, she said it proposes changes related to the COVID19 pandemic in preambular paragraph 26.

On amendment L.78, she said it replaces the words humanitarian situations with the words humanitarian emergencies in preambular paragraph 27 and removes the non-factual list of risks faced by girls because of the pandemic, including female genital mutilation and obstetric fistula.

On amendment L.79, she said it proposes changes to operative paragraph 22, aligning new unagreed passages with consensus language from the 2030 Agenda.

On amendment L.80, she said it proposes changes to operative paragraph 23, on measures to be taken against the pandemic, which aim to replace terminology in it with terms mentioned in previous agreements.

Turning to amendment L.81, she said it aims to clarify clear inconsistences in references to children and adolescents in operative paragraph 23(a), by deleting the words and adolescents. Adolescents are also children, she stressed.

Meanwhile, amendment L.82 seeks to delete a reference to marginalized people from operative paragraph 23(c), she said.

On amendment L.83, she said it aims to change vague references to humanitarian settings to humanitarian emergencies in operative paragraphs 21, 23(f) and 26.

These are far from the full list of amendments we would like to be made to the draft, she said. But due to the circumstances, we chose to focus on the most problematic passages in the new paragraphs introduced in the text.

The representative of the United States, introducing amendment L.84, said it proposes alternate language preferred by his country on sexual and reproductive health, contained in many parts of the text, including in operative paragraphs 18 and 23(a). The United States views on this are well known, he stressed.

The representative of Canada said he was confident in the quality of the negotiation process, since 114 co-sponsors had chosen to support it. He expressed deep regret over the many amendments proposed on language that has long enjoyed consensus. Through multiple bilateral consultations, Canada and Zambia made considerable efforts to accommodate other delegations concerns and made an extensive range of deletions to the text. Most proposed changes did not enjoy wide support, he said, adding that it is unfortunate that this same unfair pattern of negotiation by amendment has been witnessed in other drafts. It suggests that it is not the text under consideration that is the problem, he said. The changes proposed by the United States would be irresponsible to make, given that negative outcomes related to provisioning of reproductive and sexual healthcare services are the leading cause of death of girls aged between 15 and 19 worldwide. Therefore, Canada is voting against all proposed amendments, and calls on other States to do so.

The representative of Germany, speaking on behalf of the European Union, welcomed the fair, inclusive consultations by facilitators in which all delegations, including the United States and the Russian Federation, had participated. While no delegation is pleased with the outcome, pushing for changes is not fair to others who accepted compromises, and it undermines the principles of diplomacy, she said. She expressed concern over the numerous attempts made to weaken human rights language in the text, as well as its scope. In particular, she took issue with the proposed change to operative paragraph 23, which would replace the word victim with the word people, which would send a negative signal to all girls, who are subjected to harmful practices, she said, adding that she would oppose all amendments.

The representative of Costa Rica, speaking on behalf of a large crossregional group of countries, expressed regret about the approach of proposing multiple amendments, which goes against the Committees working methods as well as the principles of multilateralism. Language in the text pertaining to health-care services is long agreed upon and must be recognized as striking a balance to accommodate different views on the scope of healthcare needs. Moreover, terms such as sexual and reproductive healthcare services have been used since the 1990s and encompass a wide range of positions. Such attempts to undermine the normative framework underpinning the Committees work is deeply unfortunate. Costa Rica will vote against the amendments and she urged all delegates to vote against them as well.

The representative of the United Kingdom welcomed the new parts of the text, which outline the devastating impact of the pandemic, and said he supported national and international efforts to create inclusive societies for everyone, regardless of their marital status. He expressed deep disappointment with the Russian Federations proposed changes, which are highly disruptive and undermine work done to achieve consensus. He also expressed regret over the amendment proposed by the United States, which touches on consensus language used by the Committee and other United Nations bodies for many years. Any attempt to reduce access to healthcare services to girls, including family planning services, would be detrimental to their health, educational access and life choices, he said.

The representative of Argentina, aligning with the statement made by Costa Rica, said the draft provides alarming figures for child, early and forced marriage, which could have been avoided by 2030. She expressed regret about the last-minute amendments aimed at weakening consensus that was built years ago and are unjust to those who participated in negotiations in good faith. It also sets a bad precedent, she said, adding that she will vote against the amendments and encourages other States to do so. We cannot accept language that restricts the rights of women and girls, she stressed.

The Committee then took up the draft amendment L.77, which it proceeded to reject by a recorded vote of 109 against to 20 in favour, with 31 abstentions.

The Committee then turned to the draft amendment L.78, which proposed changes to preambular paragraph 27, rejecting it by a recorded vote of 111 against to 21 in favour, with 29 abstentions.

The Committee then took up draft amendment L.79, which proposed changes to operative paragraph 22, rejecting it by a recorded vote of 105 against to 26 in favour, with 30 abstentions.

The Committee then took up draft amendment L.80, which proposed to amend operative paragraph 23. It rejected the draft amendment by a recorded vote of 101 against to 29 in favour, with 34 abstentions.

The Committee then turned to draft amendment L.81, which it rejected by a recorded vote of 110 against to 19 in favour, with 31 abstentions.

The Committee then rejected draft amendment L.82, which proposed changes to operative paragraph 23(c), by a recorded vote of 108 against to 23 in favour, with 31 abstentions.

The Committee then rejected draft amendment L.83, which proposed changes to operative paragraphs 21, 23(f), and 26, by a recorded vote of 103 against to 24 in favour, with 37 abstentions.

The Committee then rejected draft amendment L.84, which proposed changes to preambular paragraph 23 and operative paragraphs 14, 17, 18, and 23(f), by a recorded vote of 121 against to 11 in favour, with 32 abstentions.

The Committee then approved draft resolution L.18/Rev.1, on Child, early and forced marriage, without a vote.

By its terms, the Assembly would urge Governments to respect the right to enjoy the highest attainable standard of physical and mental health, through the development and enforcement of policies and legal frameworks and the strengthening of health systems, including health information systems, that make universally accessible and available quality, gender-responsive, adolescent-friendly health services, and sexual and reproductive healthcare services.

By other terms, it would note with concern that child, early and forced marriage disproportionally affects girls who have received little or no formal education, and is itself a significant obstacle to educational opportunities and the development of employable skills for girls and young women in particular, girls who are forced to drop out of school owing to pregnancy, marriage, childbirth and/or childcare responsibilities.

The representative of Germany, speaking on behalf of the European Union in explanation of vote, said girls, especially those who are marginalized, are disproportionately affected by the secondary impact of the pandemic. Their exposure to harmful practices is of serious concern. In the context of the pandemic, girls face a double jeopardy, which sets back hard-won progress in achieving gender equality. She welcomed the action-oriented sections of the text, and its strong human rights focus, as well as its inclusion of proposed additions, which pertain to menstrual hygiene and domestic violence.

The representative of the Russian Federation said her country did not break consensus and is committed to its obligations to eliminate child marriage. However, this important subject is getting contentious due to a group of countries that stuff it with their politicized approaches, she stressed, adding that her main concerns were ignored by the authors of the draft. She expressed regret that mutually respectful dialogue was not possible, adding that she is therefore forced to disassociate from preambular paragraphs 26 and 27, as well as operative paragraphs 21, 22, 26, and 23, including sections (a) to (g). The Russian Federation is not bound by the provisions it disassociates from and does not see them as agreed-upon language in future negotiations.

The representative of the United States said he disassociates from preambular paragraph 23, as well as operative paragraphs 14, 17, 18, and 23(f), because of its concerns about phrasing related to reproductive healthcare services. The United States fully supports voluntary choice but does not recognize abortion as a method of family planning, he said.

The representative of Guatemala said child marriage is a harmful violation of human rights, and noted that her country has reproductive policies, but does not guarantee reproductive rights, nor the right to abortion, which contravenes the legislation of Guatemala.

The representative of Qatar, likewise, said any mention of sexual and reproductive healthcare services in the text must be understood to adhere to the countrys tradition and values.

Meanwhile, the representative of Egypt said she wished to co-sponsor the draft resolution, but that any mention of sexual and reproductive healthcare services must be understood to adhere to the countrys traditions and values.

The representative of Iraq joined consensus on the draft, in compliance with its national laws and resolutions.

An observer for the Holy See expressed disappointment about the inordinate focus on issues that polarize debate and stated his reservation with two concepts used in the draft: References to sexual and reproductive healthcare services must not be understood to include access to abortion, and references to gender must be understood to apply to biological difference.

The Committee then took up the draft resolution titled Human rights treaty body system (A/C.3/75/L.39), which was introduced by the representative of Iceland, on behalf of Belgium and Slovenia. The text is similar to that adopted two years ago as Assembly resolution 73/162 and contains three notable changes.

The Committee then approved draft resolution L.39 without a vote.

By its terms, the Assembly would recognize the valuable role of each of the human rights treaty bodies in the promotion and protection of human rights and fundamental freedoms. It would reaffirm the paramount importance of the equality of the six official languages of the United Nations for the effective functioning of the human rights treaty bodies. The Assembly would reiterate its request that the SecretaryGeneral submit to the General Assembly at its seventy-seventh session a report on the status of the human rights treaty body system.

The representative of Japan said his country attaches great importance to strengthening the human rights treaty system while avoiding unnecessary duplication. It is important to optimize existing resources, which should be provided to the treaty bodies according to resolution 668/268, he said, calling on Member States to actively strengthen the treaty body system.

The Committee then turned to the draft resolution International cooperation to address and counter the world drug problem (document A/C.3/75/L.10/Rev.1).

The representative of Mexico, introducing the omnibus draft, said the issues addressed by the text affect all countries, and that the current version presents technical updates reflecting developments within the Commission on Narcotic Drugs. Mexico would like to strengthen links between specialized bodies in Vienna and discussion within United Nations Headquarters. The pandemic can generate new trends and dynamics in the global drug problem, he warned the Committee, adding that the draft calls for all States to promote a substantive exchange of information related to best practices to counter the global drug problem.

The Committee then adopted L.10/Rev.1 without a vote.

By its terms, the Assembly would reiterate its call on Member States to attain the goals and targets set out in the Political Declaration and Plan of Action on International Cooperation towards an Integrated and Balanced Strategy to Counter the World Drug Problem, adopted at its sixty-fourth session. Further, it would call on Member States to engage in cooperation aimed at countering the world drug problem on the principle of common and shared responsibility, urging them to ensure non-discriminatory access to health care and social services in prevention, primary care and treatment programmes.

The representative of the United States, delivering an explanation of vote, disassociated from operative paragraph 81, stressing that Washington, D.C., submitted a notice of withdrawal from the World Health Organization (WHO). He further disassociated from operative paragraph 109 because the text ignores consensus in Vienna and undermines the treaty-mandated obligations of the Commission on Narcotic Drugs.

The Committee then took up the draft resolution titled Literacy for life: shaping future agendas (document A/C.3/75/L.12/Rev.1), which contained no programme budget implications.

The representative of Mongolia, introducing the draft resolution, described literacy as a building block for achieving human rights. It is crucial to promote literacy as an integral part of the right to education, she said, noting that new elements of the draft reflect the progress made in literacy. However, the outbreak of COVID19 has forced schools to close in more than 190 countries, affecting 90 per cent of the worlds students. Many non-literate people have been the hardest hit by the economic, social and educational impact of the pandemic, she added.

The Committee then approved draft resolution L.12/Rev.1 without a vote.

By its terms, the Assembly would urge international development partners and Governments to cooperate in ensuring that sufficient and sustainable funds are mobilized by and channelled through existing international financing mechanisms for education including during the COVID19 pandemic and that they also explicitly target and benefit youth and adult literacy. It also would call on States to implement the 2030 Agenda, including all literacy-related Sustainable Development Goals and targets.

The representative of the United States underscored that the 2030 Agenda is non-binding and does not create rights or obligations under international law, nor does it create any new financial commitments. The United States recognizes the 2030 Agenda as a global framework for sustainable development that can help countries to work towards global peace and prosperity. He welcomed the call for shared responsibility, including national responsibility in the 2030 Agenda, emphasizing that all countries have a role to play in achieving its vision.

Next, the Committee took up the draft Intensification of efforts to end obstetric fistula (document A/C.3/75/L.17).

The representative of Senegal, speaking on behalf of the African Group, introduced the draft noting that SecretaryGenerals reports on the rights of women are a clear representation of the urgent need for action. Citing the health consequences of obstetric fistula, he said the condition mainly affects women in underdeveloped communities. He underscored that the draft has always been adopted by consensus and noted that the current version presents technical updates. As such, he regretted the late submission of amendments and called on Member States to vote against the proposed changes.

The representative of the United States introduced amendments L.73 and L.86, stating that they would replace language on sexual and reproductive health and remove references to UNFPA and WHO. He said the amendments were tabled within the deadline, and the claim that they were last-minute submissions was inaccurate.

The representative of Denmark, speaking on behalf of a group of countries, voiced regret that the amendments would modify agreed-upon language on the scope of womens health needs. Acknowledging that sexual and reproductive health could be controversial issues, she noted that through the 2030 Agenda, States committed themselves to advancing reproductive health rights.

The representative of Germany, speaking on behalf of the European Union, said it goes against the practice of the Committee to present an amendment to a rollover draft. She called for a redoubling of efforts to enhance sexual and reproductive rights, especially as resources for such initiatives have been diverted to address the COVID19 pandemic.

The representative of Senegal said the African Group decided to submit a technical update on the draft that was duly communicated to Member States. He expressed regret that one delegation presented multiple amendments and that those proposed changes had not been presented earlier in the process.

The Committee then decided by a recorded vote of 141 against to 6 in favour (Belarus, Nauru, Qatar, Russian Federation, Tonga, United States), with 18 abstentions, to reject amendment L.73.

By a recorded vote of 153 against to 1 in favour (United States), with 11 abstentions, the Committee also rejected amendment L.86.

The Committee then approved draft resolution L.17 as a whole without a vote. Through its terms, the Assembly would stress the need to address as causes of obstetric fistula the links between poverty, lack of or inadequate education, gender inequality, lack of or inadequate access to healthcare services, including sexual and reproductive healthcare services, early childbearing and child, early and forced marriage. The Assembly would also request the Campaign to End Fistula to develop a road map for accelerating action to end obstetric fistula within a decade, towards achieving the 2030 Agenda.

The representative of Guatemala, delivering an explanation of vote after action on L.17, said she joined consensus on the draft because it underscores the link between poverty and inadequate access to health services for women. She expressed reservations related to operative paragraph 3, as issues of reproductive rights could be misinterpreted.

The representative of the United States said untreated fistula can have devastating effects on women and that his country funds related projects that have helped thousands of women. He expressed regret that the two amendments were rejected, and disassociated from preambular paragraph 9 and operative paragraphs 2 and 3. There is no international right to abortion, he said, adding that the draft must not single out specific organizations, and rather, refer to broader relevant partners.

The representative of Sudan said that, despite her delegations sponsorship of the draft, she believes that States have the sovereign right to implement policies consistent with their national legislation.

The Committee then took up the draft resolution titled Human rights and extreme poverty (document A/C.3/75/L.43/Rev.1), which contained no programme budget implications.

The Committee approved draft resolution L.43/Rev.1 without a vote.

By the text, the Assembly would emphasize that extreme poverty is a major issue to be addressed by Governments, the United Nations, international financial institutions, the private sector, civil society and community-based social organizations. It would reaffirm that political commitment is a prerequisite for the eradication of poverty. Further, it would call on Member States to design recovery strategies based on risk-informed, sustainable financing policies, supported by integrated national financing frameworks in accordance with the Addis Ababa Action Agenda of the Third International Conference on Financing for Development. It would also call on States to implement gender-responsive social protection policies, as well as fiscal policies that promote gender equality and the empowerment of all women and girls.

The representative of the United States welcomed references to persons with disabilities, calling for a more inclusive approach to development. This is particularly important as persons with disabilities are more likely to experience adverse socioeconomic outcomes, which impact their access to health care, education and employment. He further welcomed the integration of the United Nations Guiding Principles on Business and Human Rights in preambular paragraph 22 and operative paragraph 4. Opposing the assertion in preambular paragraph 22 that extreme poverty may amount to a threat to the right to life, he cited article 6 of the International Covenant on Civil and Political Rights, which prohibits arbitrary deprivation of life by State actors.

The representative of Somalia raised a point of clarification. Recalling the principles of universality, impartiality, objectivity and non-selectivity, he clarified that Somalia is not a signatory to a statement on the human rights situation in Belarus. In New York and Geneva, and as a Human Rights Council member and country that advances human rights, Somalia disassociates from that statement.

The Committee then took up the draft resolution titled, Intensification of efforts to prevent and eliminate all forms of violence against women and girls (document A/C.3/75/L.19/Rev.1), which the Chair noted had no programme budget implications.

The representative of the Netherlands, presenting the draft, highlighted the dramatic increase in violence against women and girls during the COVID19 pandemic. The draft expresses an unambiguous condemnation of violence, proposing measures to strengthen collective action. It presents a global compromise, based on agreed language, including on the socalled sensitive issues. We all had to compromise, he said, noting that the text represents delicate balance and inviting all Member States to reject the hostile amendments presented.

The representative of the Russian Federation, introducing amendments L.59 through L.65, turned first to L.59, which concerns preambular paragraph 16 and the phrasing including intimate partner violence that was not discussed during negotiations. Amendment L.60 seeks to address inconsistencies in the wording of preambular paragraph 28 related to paid work for girls. Amendment L.61 concerns operative paragraph 6 (b) and proposes that after the word girls, to add the words with appropriate direction and guidance from parents or legal guardians. Amendment L.62 opposes the term femicide which is not widespread. On the basis of previously agreed language, the Russian Federation proposes to replace the words including femicide with the words also known as femicide in certain regions of the world. Amendment L.63 proposes to delete operative paragraph 11. Amendment L.64 opposes the language of operative paragraph 13. The focus of amendment L.65 is on operative paragraph 17, he said, suggesting to replace the words taking into account their diverse situations and conditions with the phrase while respecting their diverse situations and conditions. The amendments balance and improve the document, she said, calling on States to support them.

The representative of the United States presented amendments L.69 through L.71, explaining that L.69 concerns the final preambular paragraph and proposes to replace the words essential health services with the words responsive interventions to meet their health needs. Amendment L.70 proposed to delete operative paragraph 15. Amendment L.71 focuses on operative paragraph 6 (i), proposing to replace the words comprehensive education that is relevant to cultural contexts with the culturally sensitive, healthfocused sex education and after the words reproductive health add in accordance with national legislation and programmes.

The representative of the United Kingdom welcomed the draft resolutions focus on genderbased violence during the pandemic. She expressed deep disappointment to see multiple amendments seeking to weaken language on sexual and reproductive rights. Opposing the efforts to modify previously agreed language, she rejected the amendments and encouraged all other States to do the same.

The representative of South Africa, also speaking for several other countries, said the proposed amendments contradict the principle of multilateralism and longstanding agreed language. Terminology, such as sexual and reproductive health, was agreed upon in the mid1990s. She expressed regret that Member States have been forced to vote and urged delegations to reject the amendments.

The representative of Egypt, commenting on amendment L.59, said the concept of intimate partner violence remains unclear and not internationally agreed upon. Many countries disassociated from this paragraph during the adoption of the resolution during the Assemblys seventyfirst session, she recalled, expressing surprise to see the concept return during the current session. Egypt will vote in favour of the amendment. On amendment L.62, Egypt does not support the change in agreed language, and thus, will vote in favour of the presented amendment. On L.70, she said Egypt has consistently disassociated from operative paragraph 15 and will vote in favour of the amendment.

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Third Committee Approves 11 Drafts, among Them 4 Covering Women's Rights, Omnibus Text on High Commissioner for Refugees Report, as Myriad Amendments...

Christakis’ Book on COVID-19 Featured in the New York Times – The National Herald

NEW YORK Apollo's Arrow: The Profound and Enduring Impact of Coronavirus on the Way We Live by Nicholas A. Christakis offers a riveting account of the impact of the coronavirus pandemic as it swept through the U.S. in 2020, and of how the recovery will unfold in the coming years. The book was featured in the New York Times on November 3, just before news broke of the developments in vaccines from Pfizer and more recently Moderna.

Drawing on momentous (yet dimly remembered) historical epidemics like the 1918 influenza pandemic, contemporary analyses, and cutting-edge research from a range of scientific disciplines, bestselling author, physician, sociologist, and public health expert Christakis explores what it means to live in a time of plague an experience that is paradoxically uncommon to the vast majority of humans who are alive, yet deeply fundamental to our species.

Unleashing new divisions in our society as well as opportunities for cooperation, this 21st-century pandemic has upended our lives in ways that will test, but not vanquish, our already frayed collective culture. Featuring new, provocative arguments and vivid examples ranging across medicine, history, sociology, epidemiology, data science, and genetics, Apollo's Arrow envisions what happens when the great force of a deadly germ meets the enduring reality of our evolved social nature.

The title refers to the arrows, representing plague, that Apollo rained down on the Greeks in Book 1 of the Iliad, the Times reported, noting that the book is a useful contribution to this initial wave of COVID books, sensible and comprehensive, intelligent and well sourced.

Questions about where the virus originated, how it first infected people, and how it is evolving are still being examined by scientists who are trapping wildlife in China, taking fecal samples and blood, culturing viruses, sequencing genomes from bats, pangolins and humans, and comparing them, as the clock ticks, the Times reported.

The National Herald

Apollo's Arrow: The Profound and Enduring Impact of Coronavirus on the Way We Live by Nicholas A. Christakis. (Photo: Amazon)

Apollo's Arrow is a broad survey, not a deep dive, and sweeps across most of the signal topics: the inept early responses to the outbreak, first in China and then in the United States; the back story of modern pandemics and pandemic threats, notably the 1918 influenza and SARS in 2003; the social shutdowns, the mask issue and the tension between civil liberties and public health; the grief, fear and lies that make a pandemic emotionally as well as medically punishing; the social and economic changes, forced by this virus, that may become permanent; the general question of how plagues end and the specific, more speculative question of how this one might, the Times reported.

Since Christakis is a physician and sociologist, the co-author of an earlier book about social networks and how they shape lives, the co-author also of an influential paper on `social contagion theory' and the co-director of the Institute for Network Science at Yale, one naturally expects that `network science' might afford him special insight into COVID-19, the Times reported, adding that this book delivers on that expectation moderately, with a short section on the superspreader phenomenon and such disease-math variables as the basic reproduction number (the average number of persons infected by each infected person in a nave population), the case fatality rate, the threshold for herd immunity and a few others that have become familiar in recent months.

The book also includes dispersion which is the variation in actual (not average) reproduction number from one infected person to another, the Times reported, noting that if some people cause few secondary infections and some cause many, the dispersion is high. The dispersion of COVID-19 is high.

Christakis explains the high dispersion may be partially due to some individuals simply shed more virus, or wash their hands less, or refuse to wear masks or cough more, another contributor to superspreading, but there are also certain people have many more social contacts than the average, the Times reported.

Christakis calls those `popular people,' and notes that they `are more likely to become infected themselves as well as more likely to infect numerous others,' the Times reported, adding that he illustrates this with some dots-and-lines network figures, showing who might have contact with whom.

Although superspreader events in a choir, at a funeral, during a White House reception seem alarming, the existence of high variation in reproduction number for COVID-19 may actually have an ameliorating effect, the Times reported, noting that according to Christakis, it may reduce the threshold for herd immunity, since `popular people' are more likely to get infected early in the pandemic, and most of them will survive, presumably with some immunity.

And if all the popular people became immune early, relatively more paths for the virus to spread through society would be cut off, Christakis writes, the Times reported, adding that that's the good news, but because of its capacity to spread from asymptomatic cases and its relatively low case fatality rate, Christakis estimates, COVID-19 may still infect 40 percent of the global human population, and possibly as much as 60 percent, unless a vaccine becomes available soon.

Christakis also examines the idea that the virus may become less virulent, noting that one way a pandemic can come to an end is that the virus mutates over a period of years to get much milder, the Times reported.

Christakis offers the example of the virus called OC43 is a human coronavirus that causes nothing more severe than the common cold, the Times reported, noting that in fact, along with one other coronavirus, it accounts for as much as 30 percent of all colds, and Christakis cites research suggesting that OC43 spilled into people, from cattle, around 1890, which happened to coincide with the beginning of a severe pandemic that was known as the `Russian flu,' because its first major outbreak occurred in St. Petersburg, in December 1889.

This `flu' swept out of Russia, across Europe, to the United States and much of the rest of the world, as fast as trains and ships could carry it, killing about a million people, the Times reported, noting that Christakis suggests that the 1890 event was a pandemic of OC43, a coronavirus passed to humans from some Russian cow.

After being among us for a century, this virus would have further evolved to be a mild pathogen that just causes the common cold today, Christakis writes, the Times reported, noting that concerning COVID-19 mutating into a milder form, it is still too early to know.

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Christakis' Book on COVID-19 Featured in the New York Times - The National Herald

How the IVF lab influences the chance of implantation after embryo transfer – ESHRE

A well attended online Campus meeting in November considered implantation from clinical, embryological and endometrial perspectives, but also focused on the day-to-day working of the IVF lab.

An online Campus meeting in November, with more than 250 remotely registered, reviewed the latest on successful and failed implantation from the perspectives of the meetings three organising SIGs (Embryology, Stem Cells and Implantation & Early Pregnancy). But what was also high on the meetings agenda were the effects which everyday laboratory practices might have on the fate of the embryo after transfer.

Barcelona embryologist Gemma Arroyo noted chromosomal testing and culture conditions as prominent factors but also added quality management systems, lab design and location, ambient conditions (lighting, air quality), biosecurity and culture equipment as important in the optimisation of embryo viability. For example, air conditioning, she said, should have air recycling at least 15 times per hour, with control of circulating particles and air pressure.(1) Similarly, she advised that oxygen concentrations during incubation would affect outcome, noting a Cochrane review supporting embryo culture with low oxygen concentrations for improved success rates in IVF and ICSI.(2) However, a recent study in which oxygen levels were reduced from 5% (low) to 2% (ultra low) found no added benefit.(3) Similarly, fluctuations in pH concentrations have been evident in blastulation rate reduction and alterations in gene expression (raised pH) and in fetal weight (lower pH).

While the introduction of time-lapse systems has allowed labs to maintain consistent and controlled culture environments, no such consistency is yet evident in the culture media single-step or sequential - behind the huge global shift to blastocyst transfer. Arroyo described several studies meta-analyses and RCTs reflecting inconsistent comparative results in blastulation and outcome. For example, a systematic review performed by ESHREs SIG Embryology co-ordinator Ioannis Sfontouris and colleagues found insufficient evidence to identify either one as superior, despite the practical advantages of single-step and higher blastocyst formation rates.(4) Similarly, Ubaldis group in Rome found no differences in cumulative delivery rates between the two approaches.(5)

While acknowledging the no-touch stability which time-lapse systems provide, Arroyo nevertheless recommended that their routine adoption should remain an experimental strategy. She noted that no single morphokinetic parameter has so far been consistently shown to predict implantation - indeed, with considerable disagreement over which parameters are even useful, normal or abnormal. This echoed the conclusions of ESHREs recent recommendations on time-lapse, that a clear clinical benefit of its use, an increase in IVF success rates, remains to be proven.(6) However, as the recommendations also noted, hopes of an outcome advantage are not lost.

So, as Ioannis Sfontouris asked of the lab, are we better than nature? Well, nature is certainly not perfect, as Johannes Ott emphasised before his presentation on routine office hysteroscopy before IVF. Citing a recent meta-analysis, he reported that reproductive failure is more common than success, and that embryo quality is implicated in many of these failures.(7) So is embryo culture, and notably extended culture, responsible for compromising embryo quality, asked Sfontouris. He reviewed the pros and cons of embryo transfer from day 1 to day 7 and concluded that, despite the potential for extended culture to trigger epigenetic changes, blastocyst transfer is associated with a higher pregnancy and live birth in the fresh cycle (though similar rates in cumulative cycles), a shorter time to pregnancy, and a more pronounced benefit in good-prognosis patients (while poor prognosis patients may benefit from cleavage-stage transfer.

Abha Maheshwari from the Aberdeen Fertility Centre in Scotland also found a distinction between the effect of ovarian stimulation in the fresh and frozen cycle, indicating that supraphysiological estrogen doses may affect implantation via the uterus. Describing ovarian stimulation as the most important thing in ART, and recognising the shift in defined success from pregnancy per cycle to cumulative healthy delivery, she urged the need of a very delicate balance between generating an adequate number of eggs while not impairing uterine receptivity.

1. Mortimer D, Cohen J, Mortimer ST, et al. Cairo consensus on the IVF laboratory environment and air quality: report of an expert meeting. Reprod Biomed Online 2018; 36: 658-674. doi:10.1016/j.rbmo.2018.02.005.2. Bontekoe S, Mantikou E, van Wely M, et al. Low oxygen concentrations for embryo culture in assisted reproductive technologies. Cochrane Database Syst Re 2012; CD008950. doi:10.1002/14651858.CD008950.pub2.3. De Munck D, Janssens R, Segers I, et al. Influence of ultra-low oxygen (2%) tension on in-vitro human embryo development. Hum Reprod 2019; 34: 228-234. doi:10.1093/humrep/dey370.4. Sfontouris IA, Martins WP, Nastri CO, et al. Blastocyst culture using single versus sequential media in clinical IVF: a systematic review and meta-analysis of randomized controlled trials. J Assist Reprod Genet 2016; 33: 12611272. doi:10.1007/s10815-016-0774-5.5. Cimadomo D, Scarica C, Maggiulli R, et al. Continuous embryo culture elicits higher blastulation but similar cumulative delivery rates than sequential: a large prospective study. J Assist Reprod Genet 2018; 35: 1329-1338. doi:10.1007/s10815-018-1195-4.6. ESHRE working group on time-lapse technology. Good practice recommendations for the use of time-lapse technology. Hum Reprod Open 2020; 2: doi.org/10.1093/hropen/hoaa0086. Craciunas L, Gallos I, Chu J, et al. Conventional and modern markers of endometrial receptivity: a systematic review and meta-analysis. Hum Reprod Update 2019; 25: 202-223. doi:10.1093/humupd/dmy044.

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How the IVF lab influences the chance of implantation after embryo transfer - ESHRE

Fertility treatment and COVID-19: lessons from, and for, lockdown – BioNews

2 November 2020

This year has seen a variety of measures and restrictions the most stringent and fiercely debated being 'lockdowns' introduced around the world in order to address the COVID-19 pandemic. This week, England is due to enter a lockdown which is expected to last for at least a month. What will this mean for fertility patients?

Authorities in England hope to avoid mandatory closure of clinics, of the sort that was imposed during the UK's previous lockdown. The country's fertility regulator the Human Fertilisation and Embryology Authority (HFEA) has said that there are currently 'no plans to implement a national closure of fertility clinics', but has noted that 'we expect all clinics to demonstrate how their service can be safely maintained and how they can minimise any possible further impact on the wider NHS'.

There are important lessons to be learned from the UK's previous lockdown, as well as from the experiences of other countries, when it comes to supporting fertility patients through these challenging times. That is why this coming Thursday (5 November) the day that England's new lockdown measures are expected to begin the Progress Educational Trust (PET) will be holding a free-to-attend online event, from 5pm-6.30pm (GMT), entitled 'Lessons from Lockdown: How to Improve Support for Fertility Patients'.

At this event, we will begin by looking back at early April 2020, when UK fertility clinics closed their doors. This disrupted and delayed the treatment of thousands of patients. An atmosphere of uncertainty prevailed, with little clarity as to when treatments could resume, how waiting lists and funding arrangements would be affected, or how patients would be prioritised once clinics reopened.

This situation added to the stress and anxiety experienced by many patients. Infertility can be associated with a sense of lack of control, even at the best of times, and for some patients this feeling was intensified during and after lockdown.

Things improved in May, when the HFEA issued guidance allowing clinics to begin reopening if they could meet certain criteria (see BioNews 1045). Even then, however, the situation was inconsistent across the UK. Some patients were able to resume treatment almost immediately, while others grew increasingly frustrated because they were unable to access information, make plans or receive adequate support.

Thursday's event which we are producing in partnership with University College London's EGA Institute for Women's Health, with sponsorship from CooperSurgical will explore questions including:

What have been the greatest concerns and anxieties of fertility patients during the recent period?

What support do fertility patients need in such circumstances? And what support have they actually received?

What lessons should be taken on board by fertility clinics, policymakers and others, as we enter another lockdown?

How can fertility patients best be supported in relation to COVID-19? Or in the event of a different disease pandemic? Or in any such period of widespread disruption and uncertainty?

To help us answer these questions, we will be hearing from academics who have led research into fertility patients' experiences of the pandemic (Professor Jacky Boivin and Dr Zeynep Gurtin), from a patient and advocate whose own fertility treatment has been disrupted (Seetal Savla), and from a fertility counsellor who has been supporting patients during this difficult period (Carmel Dennehy).

All are welcome to attend Thursday's event. Find out more here, and register for your free place here.

After this week, we will continue to explore these issues at PET's annual conference, which for the first time we will be holding entirely online. The conference is entitled 'Fertility, Genomics and COVID-19', and is taking place from 9.15am-5.30pm (GMT) on Wednesday 9 December.

The conference will open with a session entitled 'The Impact of COVID-19 on the Fertility Sector', where speakers will include the chair of the HFEA (Sally Cheshire), the chair of the British Fertility Society (Dr Jane Stewart) and a leading figure in medical ethics (Professor Julian Savulescu).

The conference will close with a session entitled 'Resuming Treatment: What Can European Countries Learn from One Another?', featuring an international lineup of speakers (Dr Anna Veiga, Dr Luca Gianaroli, Dr Edgar Mocanu and Dr Nathalie Vermeulen) from the COVID-19 Working Group of the European Society of Human Reproduction and Embryology.

The conference's other sessions are detailed in the full timetable, and many other speakers are listed in the full lineup. Register to attend here, and note that the Institute of Medical Ethics has provided funding for 20 medical students to attend the conference free of charge to apply for one of these places, please email.

As with all of PET's public events, Thursday's 'Lessons from Lockdown' event and next month's 'Fertility, Genomics and COVID-19' conference will devote substantial time to letting you put questions and comments to the speakers. At our online events, you have the additional option of making contributions either identifiably or anonymously.

2020 continues to be a turbulent year, but PET is more determined than ever to provide you with a wide variety of information, opinion and opportunities for discussion. See details of all our upcoming events here, and if you are able to do so, please support our efforts by becoming a registered Friend of PET.

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Fertility treatment and COVID-19: lessons from, and for, lockdown - BioNews

Human Reproductive System – Male and Female Reproductive …

Overview

Reproduction can be defined as the biological process of producing a new individual or an offspring identical to the parents. This process ensuresthe increase in the number of individuals of a species when conditions are favourable. It is one of the fundamental characteristics of living things and an essential life process.

There are two types of reproduction asexual and sexual.

Sexual Reproduction This process of reproduction is very complex that involves the formation and transfer of gametes, followed by fertilization, the formation of the zygote, andembryogenesis.

Asexual Reproduction This process of reproduction involves only one parent and the new offspring produced is genetically similar to the parent.

Also read:Asexual Reproduction

All human beings undergo a sexual mode of reproduction. In this process, two parents are involved in producing a new individual. Offspring are produced by the fusion of gametes (sex cells) from each parent. Hence, the newly formed individual will be different from parents, both genetically and physically. Human reproduction is an example of sexual reproduction.

In human beings, both males and females have different reproductive systems; hence, they are known to exhibit sexual dimorphism. Males have testes- also calledtesticles, while the females have a pair of ovaries.

Also read:Sexual Reproduction

The reproduction in human beings involves the fusion of male and female gametes produced in their reproductive system. The male reproductive system is different from the female reproductive system, both in structure and in function.

Male Reproductive System

The male gametes, i.e., sperms are produced within the male reproductive system. Sperms are small unicellular structures with a head, middle piece, and a tail.

The male reproductive system consists of :

Explore more:Male Reproductive System

Female Reproductive System

The female reproductive system is active before, during and after fertilization as well. It consists of the following parts:

Female reproductive system has two functions

During puberty, eggs in the ovaries start to mature. One of the ovaries releases the matured ovum in every 28 to 30 days and is called ovulation.

The process of fusion of sperm with egg (ovum) to produce zygote is called fertilization. Fertilization is a crucial stage of reproduction in human beings. The fertilized egg is called the zygote. Zygote starts to divide into many cells and develops into an embryo.

Embryo moves into the uterus and gets attached to its walls. This process is referred to as implantation, and the implanted embryo eventually develops into a fetus.

Learn more about reproduction in human beings, its types, process, significance and other related topics atBYJUS Biology

Reproduction is a fundamental biological process of producing young ones or offspring, which are identical to their parents.

Fertilization is the fusion of male and haploid female gametes (egg and sperm) resulting in the formation of a diploid zygote.

Cell Differentiation is the process through which a young and immature cell develops into a specialized and matured cell.

The process of reproduction in humans usually begins with copulation, followed by the Pre-fertilization, Fertilization, and Post-fertilization. During this fundamental process, both male and female reproductive organs play an important role.

In Biology, the trimester system mainly refers to three months. A complete pregnancy period lasts for 38-40 weeks or 9 months from the first day of your last menstrual period to the birth of the baby. This period is divided into three stages, which are collectively called trimesters.

Parturition is the process of delivering the baby after the completion of pregnancy or a fully grown developed fetus and placenta from the uterus to the vagina to the outside world. This process occurs in three stages, which includes:

Humans reproduce their young ones sexually by the interaction between the male and female reproductive organs.

Sexual Reproduction is carried out by a set of events and are divided into three stages: Pre-fertilization, Fertilization, and Post-fertilization

Reproduction is a fundamental biological process carried out by different living organisms to produce their young ones or offspring. In human, reproduction plays a significant role in the continuity of species from one generation to another generation. Without reproduction, there would no life existing on the planet earth.

Both sexual and asexual are two different modes of reproduction. Sexual mode reproduction takes place in all multicellular organisms including humans, animals, and higher plants. Asexual mode reproduction occurs only in lower invertebrates and other simpler living species such as amoeba, bacteria, and hydra.

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Human Reproductive System - Male and Female Reproductive ...

Human sexuality

This article is about human sexual anatomy, sexuality and perceptions. For information specifically about sexual activities, see Human sexual activity.

The way people experience and express themselves sexually

Human sexuality is the way people experience and express themselves sexually.[1][2] This involves biological, erotic, physical, emotional, social, or spiritual feelings and behaviors.[3][4] Because it is a broad term, which has varied with historical contexts over time, it lacks a precise definition.[4] The biological and physical aspects of sexuality largely concern the human reproductive functions, including the human sexual response cycle.[3][4]

Someone's sexual orientation is their pattern of sexual interest in the opposite or same sex.[5] Physical and emotional aspects of sexuality include bonds between individuals that are expressed through profound feelings or physical manifestations of love, trust, and care. Social aspects deal with the effects of human society on one's sexuality, while spirituality concerns an individual's spiritual connection with others. Sexuality also affects and is affected by cultural, political, legal, philosophical, moral, ethical, and religious aspects of life.[3][4]

Interest in sexual activity typically increases when an individual reaches puberty.[6] Although no single theory on the cause of sexual orientation has yet gained widespread support, there is considerably more evidence supporting nonsocial causes of sexual orientation than social ones, especially for males. Hypothesized social causes are supported by only weak evidence, distorted by numerous confounding factors.[7] This is further supported by cross-cultural evidence, because cultures that are very tolerant of homosexuality do not have significantly higher rates of it.[8][9]

Evolutionary perspectives on human coupling, reproduction and reproduction strategies, and social learning theory provide further views of sexuality.[10] Sociocultural aspects of sexuality include historical developments and religious beliefs. Some cultures have been described as sexually repressive. The study of sexuality also includes human identity within social groups, sexually transmitted infections (STIs/STDs), and birth control methods.

There is considerably more evidence supporting innate causes of sexual orientation than learned ones, especially for males. This evidence includes the cross-cultural correlation of homosexuality and childhood gender nonconformity, moderate genetic influences found in twin studies, evidence for prenatal hormonal effects on brain organization, the fraternal birth order effect, and the finding that in rare cases where infant males were raised as girls due to physical deformity, they nevertheless turned out attracted to females. Hypothesized social causes are supported by only weak evidence, distorted by numerous confounding factors.[7]

Cross-cultural evidence also leans more toward non-social causes. Cultures that are very tolerant of homosexuality do not have significantly higher rates of it. Homosexual behavior is relatively common among boys in British single-sex boarding schools, but adult Britons who attended such schools are no more likely to engage in homosexual behavior than those who did not. In an extreme case, the Sambia people ritually require their boys to engage in homosexual behavior during adolescence before they have any access to females, yet most of these boys become heterosexual.[8][9]

It is not fully understood why genes causing homosexuality persist in the gene pool. One hypothesis involves kin selection, suggesting that homosexuals invest heavily enough in their relatives to offset the cost of not reproducing as much directly. This has not been supported by studies in Western cultures, but several studies in Samoa have found some support for this hypothesis. Another hypothesis involves sexually antagonistic genes, which cause homosexuality when expressed in males but increase reproduction when expressed in females. Studies in both Western and non-Western cultures have found support for this hypothesis.[7][11]

Psychological theories exist regarding the development and expression of gender differences in human sexuality. A number of them (including neo-analytic theories, sociobiological theories, social learning theory, social role theory, and script theory) agree in predicting that men should be more approving of casual sex (sex happening outside a stable, committed relationship such as marriage) and should also be more promiscuous (have a higher number of sexual partners) than women. These theories are mostly consistent with observed differences in males' and females' attitudes toward casual sex before marriage in the United States. Other aspects of human sexuality, such as sexual satisfaction, incidence of oral sex, and attitudes toward homosexuality and masturbation, show little to no observed difference between males and females. Observed gender differences regarding the number of sexual partners are modest, with males tending to have slightly more than females.[12]

Like other mammals, humans are primarily grouped into either the male or female sex,[13] with a small proportion (around 1% or 0.018%[14]) of intersex individuals, for whom sexual classification may not be as clear.[15]

The biological aspects of humans' sexuality deal with the reproductive system, the sexual response cycle, and the factors that affect these aspects. They also deal with the influence of biological factors on other aspects of sexuality, such as organic and neurological responses,[16] heredity, hormonal issues, gender issues, and sexual dysfunction.[17][pageneeded]

Males and females are anatomically similar; this extends to some degree to the development of the reproductive system. As adults, they have different reproductive mechanisms that enable them to perform sexual acts and to reproduce. Men and women react to sexual stimuli in a similar fashion with minor differences. Women have a monthly reproductive cycle, whereas the male sperm production cycle is more continuous.[18][19][20]

The hypothalamus is the most important part of the brain for sexual functioning. This is a small area at the base of the brain consisting of several groups of nerve cell bodies that receives input from the limbic system. Studies have shown that within lab animals, destruction of certain areas of the hypothalamus causes the elimination of sexual behavior.[citation needed] The hypothalamus is important because of its relationship to the pituitary gland, which lies beneath it. The pituitary gland secretes hormones that are produced in the hypothalamus and itself. The four important sexual hormones are oxytocin, prolactin, follicle-stimulating hormone, and luteinizing hormone.[18][pageneeded]

Oxytocin, sometimes referred to as the "love hormone,"[citation needed] is released in both sexes during sexual intercourse when an orgasm is achieved.[citation needed] Oxytocin has been suggested as critical to the thoughts and behaviors required to maintain close relationships.[21][22][verification needed] The hormone is also released in women when they give birth or are breastfeeding.[23] Both prolactin and oxytocin stimulate milk production in women.[citation needed] Follicle-stimulating hormone (FSH) is responsible for ovulation in women, which acts by triggering egg maturity; in men it stimulates sperm production.[24] Luteinizing hormone (LH) triggers ovulation, which is the release of a mature egg.[18][pageneeded]

Males also have both internal and external genitalia that are responsible for procreation and sexual intercourse. Production of spermatozoa (sperm) is also cyclic, but unlike the female ovulation cycle, the sperm production cycle is constantly producing millions of sperm daily.[18][pageneeded]

The male genitalia are the penis and the scrotum. The penis provides a passageway for sperm and urine. An average-sized flaccid penis is about 334 inches (9.5cm) in length and 115 inches (3.0cm) in diameter. When erect, the average penis is between 412 inches (11cm) to 6 inches (15cm) in length and 112 inches (3.8cm) in diameter. The penis's internal structures consist of the shaft, glans, and the root.[18][pageneeded]

The shaft of the penis consists of three cylindrical bodies of spongy tissue filled with blood vessels along its length. Two of these bodies lie side-by-side in the upper portion of the penis called corpora cavernosa. The third, called the corpus spongiosum, is a tube that lies centrally beneath the others and expands at the end to form the tip of the penis (glans).[25]

The raised rim at the border of the shaft and glans is called the corona. The urethra runs through the shaft, providing an exit for sperm and urine. The root consists of the expanded ends of the cavernous bodies, which fan out to form the crura and attach to the pubic bone and the expanded end of the spongy body (bulb). The root is surrounded by two muscles; the bulbocavernosus muscle and the ischiocavernosus muscle, which aid urination and ejaculation. The penis has a foreskin that typically covers the glans; this is sometimes removed by circumcision for medical, religious or cultural reasons.[18][pageneeded] In the scrotum, the testicles are held away from the body, one possible reason for this is so sperm can be produced in an environment slightly lower than normal body temperature.[26][27]

Male internal reproductive structures are the testicles, the duct system, the prostate and seminal vesicles, and the Cowper's gland.[18][pageneeded]

The testicles (male gonads), are where sperm and male hormones are produced. Millions of sperm are produced daily in several hundred seminiferous tubules. Cells called the Leydig cells lie between the tubules; these produce hormones called androgens; these consist of testosterone and inhibin. The testicles are held by the spermatic cord, which is a tubelike structure containing blood vessels, nerves, the vas deferens, and a muscle that helps to raise and lower the testicles in response to temperature changes and sexual arousal, in which the testicles are drawn closer to the body.[18][pageneeded]

Sperm gets transported through a four-part duct system. The first part of this system is the epididymis. The testicles converge to form the seminiferous tubules, coiled tubes at the top and back of each testicle. The second part of the duct system is the vas deferens, a muscular tube that begins at the lower end of the epididymis.[18][pageneeded] The vas deferens passes upward along the side of the testicles to become part of the spermatic cord.[25] The expanded end is the ampulla, which stores sperm before ejaculation. The third part of the duct system is the ejaculatory ducts, which are 1-inch (2.5cm)-long paired tubes that pass through the prostate gland, where semen is produced.[18][pageneeded] The prostate gland is a solid, chestnut-shaped organ that surrounds the first part of the urethra, which carries urine and semen.[18][pageneeded][25] Similar to the female G-spot, the prostate provides sexual stimulation and can lead to orgasm through anal sex.[29]

The prostate gland and the seminal vesicles produce seminal fluid that is mixed with sperm to create semen.[18][pageneeded] The prostate gland lies under the bladder and in front of the rectum. It consists of two main zones: the inner zone that produces secretions to keep the lining of the male urethra moist and the outer zone that produces seminal fluids to facilitate the passage of semen.[25] The seminal vesicles secrete fructose for sperm activation and mobilization, prostaglandins to cause uterine contractions that aid movement through the uterus, and bases that help neutralize the acidity of the vagina. The Cowper's glands, or bulbourethral glands, are two pea sized structures beneath the prostate.

The mons veneris, also known as the Mound of Venus, is a soft layer of fatty tissue overlaying the pubic bone.[30] Following puberty, this area grows in size. It has many nerve endings and is sensitive to stimulation.[18][pageneeded]

The labia minora and labia majora are collectively known as the lips. The labia majora are two elongated folds of skin extending from the mons to the perineum. Its outer surface becomes covered with hair after puberty. In between the labia majora are the labia minora, two hairless folds of skin that meet above the clitoris to form the clitoral hood, which is highly sensitive to touch. The labia minora become engorged with blood during sexual stimulation, causing them to swell and turn red.[18][pageneeded]

The labia minora are composed of connective tissues that are richly supplied with blood vessels which cause the pinkish appearance. Near the anus, the labia minora merge with the labia majora.[31] In a sexually unstimulated state, the labia minora protects the vaginal and urethral opening by covering them.[32] At the base of the labia minora are the Bartholin's glands, which add a few drops of an alkaline fluid to the vagina via ducts; this fluid helps to counteract the acidity of the outer vagina since sperm cannot live in an acidic environment.[18][pageneeded]

The clitoris is developed from the same embryonic tissue as the penis; it or its glans alone consists of as many (or more in some cases) nerve endings as the human penis or glans penis, making it extremely sensitive to touch.[33][34][35] The clitoral glans, which is a small, elongated erectile structure, has only one known functionsexual sensations. It is the main source of orgasm in women.[36][37][38][39] Thick secretions called smegma collect in the clitoris.[18][pageneeded]

The vaginal opening and the urethral opening are only visible when the labia minora are parted. These opening have many nerve endings that make them sensitive to touch. They are surrounded by a ring of sphincter muscles called the bulbocavernosus muscle. Underneath this muscle and on opposite sides of the vaginal opening are the vestibular bulbs, which help the vagina grip the penis by swelling with blood during arousal. Within the vaginal opening is the hymen, a thin membrane that partially covers the opening in many virgins. Rupture of the hymen has been historically considered the loss of one's virginity, though by modern standards, loss of virginity is considered to be the first sexual intercourse. The hymen can be ruptured by activities other than sexual intercourse. The urethral opening connects to the bladder with the urethra; it expels urine from the bladder. This is located below the clitoris and above the vaginal opening.[18][pageneeded]

The breasts are the subcutaneous tissues on the front thorax of the female body.[31] Though they are not technically part of a woman's sexual anatomy, they do have roles in both sexual pleasure and reproduction.[40] Breasts are modified sweat glands made up of fibrous tissues and fat that provide support and contain nerves, blood vessels and lymphatic vessels.[31] Their main purpose is to provide milk to a developing infant. Breasts develop during puberty in response to an increase in estrogen. Each adult breast consists of 15 to 20 milk-producing mammary glands, irregularly shaped lobes that include alveolar glands and a lactiferous duct leading to the nipple. The lobes are separated by dense connective tissues that support the glands and attach them to the tissues on the underlying pectoral muscles.[31] Other connective tissue, which forms dense strands called suspensory ligaments, extends inward from the skin of the breast to the pectoral tissue to support the weight of the breast.[31] Heredity and the quantity of fatty tissue determine the size of the breasts.[18][pageneeded]

Men typically find female breasts attractive[41] and this holds true for a variety of cultures.[42][43][44] In women, stimulation of the nipple seems to result in activation of the brain's genital sensory cortex (the same region of the brain activated by stimulation of the clitoris, vagina, and cervix).[45] This may be why many women find nipple stimulation arousing and why some women are able to orgasm by nipple stimulation alone.[40]

The female internal reproductive organs are the vagina, uterus, Fallopian tubes, and ovaries. The vagina is a sheath-like canal that extends from the vulva to the cervix. It receives the penis during intercourse and serves as a depository for sperm. The vagina is also the birth canal; it can expand to 10cm (3.9in) during labor and delivery. The vagina is located between the bladder and the rectum. The vagina is normally collapsed, but during sexual arousal it opens, lengthens, and produces lubrication to allow the insertion of the penis. The vagina has three layered walls; it is a self-cleaning organ with natural bacteria that suppress the production of yeast.[18][pageneeded] The G-spot, named after the Ernst Grfenberg who first reported it in 1950, may be located in the front wall of the vagina and may cause orgasms. This area may vary in size and location between women; in some it may be absent. Various researchers dispute its structure or existence, or regard it as an extension of the clitoris.[47][48][49]

The uterus or womb is a hollow, muscular organ where a fertilized egg (ovum) will implant itself and grow into a fetus.[18][pageneeded] The uterus lies in the pelvic cavity between the bladder and the bowel, and above the vagina. It is usually positioned in a 90-degree angle tilting forward, although in about 20% of women it tilts backwards.[31] The uterus has three layers; the innermost layer is the endometrium, where the egg is implanted. During ovulation, this thickens for implantation. If implantation does not occur, it is sloughed off during menstruation. The cervix is the narrow end of the uterus. The broad part of the uterus is the fundus.[18][pageneeded]

During ovulation, the ovum travels down the Fallopian tubes to the uterus. These extend about four inches (10cm) from both sides of the uterus. Finger-like projections at the ends of the tubes brush the ovaries and receive the ovum once it is released. The ovum then travels for three to four days to the uterus.[18][pageneeded] After sexual intercourse, sperm swim up this funnel from the uterus. The lining of the tube and its secretions sustain the egg and the sperm, encouraging fertilization and nourishing the ovum until it reaches the uterus. If the ovum divides after fertilization, identical twins are produced. If separate eggs are fertilized by different sperm, the mother gives birth to non-identical or fraternal twins.[31]

The ovaries (female gonads), develop from the same embryonic tissue as the testicles. The ovaries are suspended by ligaments and are the source where ova are stored and developed before ovulation. The ovaries also produce female hormones progesterone and estrogen. Within the ovaries, each ovum is surrounded by other cells and contained within a capsule called a primary follicle. At puberty, one or more of these follicles are stimulated to mature on a monthly basis. Once matured, these are called Graafian follicles.[18][pageneeded] The female reproductive system does not produce the ova; about 60,000 ova are present at birth, only 400 of which will mature during the woman's lifetime.[31]

Ovulation is based on a monthly cycle; the 14th day is the most fertile. On days one to four, menstruation and production of estrogen and progesterone decreases, and the endometrium starts thinning. The endometrium is sloughed off for the next three to six days. Once menstruation ends, the cycle begins again with an FSH surge from the pituitary gland. Days five to thirteen are known as the pre-ovulatory stage. During this stage, the pituitary gland secretes follicle-stimulating hormone (FSH). A negative feedback loop is enacted when estrogen is secreted to inhibit the release of FSH. Estrogen thickens the endometrium of the uterus. A surge of Luteinizing Hormone (LH) triggers ovulation.

On day 14, the LH surge causes a Graafian follicle to surface the ovary. The follicle ruptures and the ripe ovum is expelled into the abdominal cavity. The fallopian tubes pick up the ovum with the fimbria. The cervical mucus changes to aid the movement of sperm. On days 15 to 28the post-ovulatory stage, the Graafian folliclenow called the corpus luteumsecretes estrogen. Production of progesterone increases, inhibiting LH release. The endometrium thickens to prepare for implantation, and the ovum travels down the Fallopian tubes to the uterus. If the ovum is not fertilized and does not implant, menstruation begins.[18][pageneeded]

The sexual response cycle is a model that describes the physiological responses that occur during sexual activity. This model was created by William Masters and Virginia Johnson. According to Masters and Johnson, the human sexual response cycle consists of four phases; excitement, plateau, orgasm, and resolution, also called the EPOR model. During the excitement phase of the EPOR model, one attains the intrinsic motivation to have sex. The plateau phase is the precursor to orgasm, which may be mostly biological for men and mostly psychological for women. Orgasm is the release of tension, and the resolution period is the unaroused state before the cycle begins again.[18][pageneeded]

The male sexual response cycle starts in the excitement phase; two centers in the spine are responsible for erections. Vasoconstriction in the penis begins, the heart rate increases, the scrotum thickens, the spermatic cord shortens, and the testicles become engorged with blood. In the plateau phase, the penis increases in diameter, the testicles become more engorged, and the Cowper's glands secrete pre-seminal fluid. The orgasm phase, during which rhythmic contractions occur every 0.8 seconds[verification needed], consists of two phases; the emission phase, in which contractions of the vas deferens, prostate, and seminal vesicles encourage ejaculation, which is the second phase of orgasm. Ejaculation is called the expulsion phase; it cannot be reached without an orgasm. In the resolution phase, the male is now in an unaroused state consisting of a refactory (rest) period before the cycle can begin. This rest period may increase with age.[18][pageneeded]

The female sexual response begins with the excitement phase, which can last from several minutes to several hours. Characteristics of this phase include increased heart and respiratory rate, and an elevation of blood pressure. Flushed skin or blotches of redness may occur on the chest and back; breasts increase slightly in size and nipples may become hardened and erect. The onset of vasocongestion results in swelling of the clitoris, labia minora, and vagina. The muscle that surrounds the vaginal opening tightens and the uterus elevates and grows in size. The vaginal walls begin to produce a lubricating liquid. The second phase, called the plateau phase, is characterized primarily by the intensification of the changes begun during the excitement phase. The plateau phase extends to the brink of orgasm, which initiates the resolution stage; the reversal of the changes begun during the excitement phase. During the orgasm stage the heart rate, blood pressure, muscle tension, and breathing rates peak. The pelvic muscle near the vagina, the anal sphincter, and the uterus contract. Muscle contractions in the vaginal area create a high level of pleasure, though all orgasms are centered in the clitoris.[18][pageneeded][50][51][52]

Sexual disorders, according to the DSM-IV-TR, are disturbances in sexual desire and psycho-physiological changes that characterize the sexual response cycle and cause marked distress and interpersonal difficulty. The sexual dysfunctions is a result of physical or psychological disorders. The physical causes include hormonal imbalance, diabetes, heart disease and more. The psychological causes includes but are not limited to stress, anxiety, and depression.[53] The sexual dysfunction affects men and women. There are four major categories of sexual problems for women: desire disorders, arousal disorders, orgasmic disorders, and sexual pain disorders.[18][pageneeded] The sexual desire disorder occurs when an individual lacks the sexual desire because of hormonal changes, depression, and pregnancy.The arousal disorder is a female sexual dysfunction. Arousal disorder means lack of vaginal lubrication. In addition, blood flow problems may affect arousal disorder. Lack of orgasm, also known as, anorgasmia is another sexual dysfunction in women. The anorgasmia occurs in women with psychological disorders such as guilt and anxiety that was caused by sexual assault. The last sexual disorder is the painful intercourse. The sexual disorder can be result of pelvic mass, scar tissue, sexually transmitted disease and more.[54]

There are also three common sexual disorders for men including, sexual desire, ejaculation disorder, and erectile dysfunction. The lack of sexual desire in men is because of loss of libido, low testosterone. There are also psychological factors such as anxiety, and depression.[55]The ejaculation disorder has three types: retrograde ejaculation, retarded ejaculation, premature ejaculation. The erectile dysfunction is a disability to have and maintain an erection during intercourse.[56]

As one form of behavior, the psychological aspects of sexual expression have been studied in the context of emotional involvement, gender identity, intersubjective intimacy, and Darwinian reproductive efficacy. Sexuality in humans generates profound emotional and psychological responses. Some theorists identify sexuality as the central source of human personality.[57] Psychological studies of sexuality focus on psychological influences that affect sexual behavior and experiences.[17][pageneeded] Early psychological analyses were carried out by Sigmund Freud, who believed in a psychoanalytic approach. He also proposed the concepts of psychosexual development and the Oedipus complex, among other theories.[58]

Gender identity is a person's sense of their own gender, whether male, female, or non-binary.[59] Gender identity can correlate with assigned sex at birth or can differ from it.[60] All societies have a set of gender categories that can serve as the basis of the formation of a person's social identity in relation to other members of society.[61]

Sexual behavior and intimate relationships are strongly influenced by a person's sexual orientation.[62]

Sexual orientation is an enduring pattern of romantic or sexual attraction (or a combination of these) to persons of the opposite sex, same sex, or both sexes.[62] Heterosexual people are romantically/sexually attracted to the members of the opposite sex, gay and lesbian people are romantically/sexually attracted to people of the same sex, and those who are bisexual are romantically/sexually attracted to both sexes.[5]

The idea that homosexuality results from reversed gender roles is reinforced by the media's portrayal of male homosexuals as effeminate and female homosexuals as masculine.[63][pageneeded] However, a person's conformity or non-conformity to gender stereotypes does not always predict sexual orientation. Society believes that if a man is masculine he is heterosexual, and if a man is feminine he is homosexual. There is no strong evidence that a homosexual or bisexual orientation must be associated with atypical gender roles. By the early 21st century, homosexuality was no longer considered to be a pathology. Theories have linked many factors, including genetic, anatomical, birth order, and hormones in the prenatal environment, to homosexuality.[63][pageneeded]

Other than the need to procreate, there are many other reasons people have sex. According to one study conducted on college students (Meston & Buss, 2007), the four main reasons for sexual activities are; physical attraction, as a means to an end, to increase emotional connection, and to alleviate insecurity.[64]

Until Sigmund Freud published his Three Essays on the Theory of Sexuality in 1905, children were often regarded as asexual, having no sexuality until later development. Sigmund Freud was one of the first researchers to take child sexuality seriously. His ideas, such as psychosexual development and the Oedipus conflict, have been much debated but acknowledging the existence of child sexuality was an important development.[65]

Freud gave sexual drives an importance and centrality in human life, actions, and behavior; he said sexual drives exist and can be discerned in children from birth. He explains this in his theory of infantile sexuality, and says sexual energy (libido) is the most important motivating force in adult life. Freud wrote about the importance of interpersonal relationships to one's sexual and emotional development. From birth, the mother's connection to the infant affects the infant's later capacity for pleasure and attachment.[66] Freud described two currents of emotional life; an affectionate current, including our bonds with the important people in our lives; and a sensual current, including our wish to gratify sexual impulses. During adolescence, a young person tries to integrate these two emotional currents.[67]

Alfred Kinsey also examined child sexuality in his Kinsey Reports. Children are naturally curious about their bodies and sexual functions. For example, they wonder where babies come from, they notice the differences between males and females, and many engage in genital play, which is often mistaken for masturbation. Child sex play, also known as playing doctor, includes exhibiting or inspecting the genitals. Many children take part in some sex play, typically with siblings or friends.[65] Sex play with others usually decreases as children grow, but they may later possess romantic interest in their peers. Curiosity levels remain high during these years, but the main surge in sexual interest occurs in adolescence.[65]

Adult sexuality originates in childhood. However, like many other human capacities, sexuality is not fixed, but matures and develops. A common stereotype associated with old people is that they tend to lose interest and the ability to engage in sexual acts once they reach late adulthood. This misconception is reinforced by Western popular culture, which often ridicules older adults who try to engage in sexual activities. Age does not necessarily change the need or desire to be sexually expressive or active. A couple in a long-term relationship may find that the frequency of their sexual activity decreases over time and the type of sexual expression may change, but many couples experience increased intimacy and love.[68]

Human sexuality can be understood as part of the social life of humans, which is governed by implied rules of behavior and the status quo. This narrows the view to groups within a society.[17][pageneeded] The socio-cultural context of society, including the effects of politics and the mass media, influences and forms social norms. Throughout history, social norms have been changing and continue to change as a result of movements such as the sexual revolution and the rise of feminism.[71][72]

The age and manner in which children are informed of issues of sexuality is a matter of sex education. The school systems in almost all developed countries have some form of sex education, but the nature of the issues covered varies widely. In some countries, such as Australia and much of Europe, age-appropriate sex education often begins in pre-school, whereas other countries leave sex education to the pre-teenage and teenage years.[73] Sex education covers a range of topics, including the physical, mental, and social aspects of sexual behavior. Geographic location also plays a role in society's opinion of the appropriate age for children to learn about sexuality. According to TIME magazine and CNN,[full citation needed] 74% of teenagers in the United States reported that their major sources of sexual information were their peers and the media, compared to 10% who named their parents or a sex education course.[18][pageneeded]

In the United States, most sex education programs encourage abstinence, the choice to restrain oneself from sexual activity. In contrast, comprehensive sex education aims to encourage students to take charge of their own sexuality and know how to have safe, healthy, and pleasurable sex if and when they choose to do so.[74]

Proponents for an abstinence-only education believe that teaching a comprehensive curriculum would encourage teenagers to have sex, while proponents for comprehensive sex education argue that many teenagers will have sex regardless and should be equipped with knowledge of how to have sex responsibly. According to data from the National Longitudinal Survey of Youth, many teens who intend to be abstinent fail to do so, and when these teenagers do have sex, many do not use safe sex practices such as contraceptives.[75]

Sexuality has been an important, vital part of human existence throughout history.[76][pageneeded] All civilizations have managed sexuality through sexual standards, representations, and behavior.[76][pageneeded]

Before the rise of agriculture, groups of hunter/gatherers (H/G) and nomads inhabited the world. Within these groups, some implications of male dominance existed, but there were signs that women were active participants in sexuality, with bargaining power of their own. These hunter/gatherers had less restrictive sexual standards that emphasized sexual pleasure and enjoyment, but with definite rules and constraints. Some underlying continuities or key regulatory standards contended with the tension between recognition of pleasure, interest, and the need to procreate for the sake of social order and economic survival. H/G groups also placed high value on certain types of sexual symbolism.

Two common tensions in H/G societies are expressed in their art, which emphasizes male sexuality and prowess, with equally common tendencies to blur gender lines in sexual matters. One example of these male-dominated portrayals is the Egyptian creation myth, in which the sun god Atum masturbates in the water, creating the Nile River. In Sumerian myth, the Gods' semen filled the Tigris.[76][pageneeded]

Once agricultural societies emerged, the sexual framework shifted in ways that persisted for many millennia in much of Asia, Africa, Europe, and parts of the Americas. One common characteristic new to these societies was the collective supervision of sexual behavior due to urbanization, and the growth of population and population density. Children would commonly witness parents having sex because many families shared the same sleeping quarters. Due to landownership, determination of children's paternity became important, and society and family life became patriarchal.[citation needed] These changes in sexual ideology were used to control female sexuality and to differentiate standards by gender. With these ideologies, sexual possessiveness and increases in jealousy emerged. With the domestication of animals, new opportunities for bestiality arose.

Males mostly performed these types of sexual acts and many societies acquired firm rules against it. These acts also explain the many depictions of half-human, half-animal mythical creatures, and the sports of gods and goddesses with animals.[76] While retaining the precedents of earlier civilizations, each classical civilization established a somewhat distinctive approach to gender, artistic expression of sexual beauty, and to behaviors such as homosexuality. Some of these distinctions are portrayed in sex manuals, which were also common among civilizations in China, Greece, Rome, Persia, and India; each has its own sexual history.[76][pageneeded]

Before the High Middle Ages, homosexual acts appear to have been ignored or tolerated by the Christian church.[77] During the 12th century, hostility toward homosexuality began to spread throughout religious and secular institutions. By the end of the 19th century, it was viewed as a pathology.[77]

During the beginning of the industrial revolution of the 18th and 19th centuries, many changes in sexual standards occurred. New, dramatic, artificial birth control devices such as the condom and diaphragm were introduced. Doctors started claiming a new role in sexual matters, urging that their advice was crucial to sexual morality and health. New pornographic industries grew and Japan adopted its first laws against homosexuality. In Western societies, the definition of homosexuality was constantly changing; Western influence on other cultures became more prevalent. New contacts created serious issues around sexuality and sexual traditions. There were also major shifts in sexual behavior. During this period, puberty began occurring at younger ages, so a new focus on adolescence as a time of sexual confusion and danger emerged. There was a new focus on the purpose of marriage; it was increasing regarded as being for love rather than only for economics and reproduction.[76][pageneeded]

Havelock Ellis and Sigmund Freud adopted more accepting stances toward homosexuality; Ellis said homosexuality was inborn and therefore not immoral, not a disease, and that many homosexuals made significant contributions to society.[77] Freud wrote that all human beings as capable of becoming either heterosexual or homosexual; neither orientation was assumed to be innate.[63][pageneeded] According to Freud, a person's orientation depended on the resolution of the Oedipus complex. He said male homosexuality resulted when a young boy had an authoritarian, rejecting mother and turned to his father for love and affection, and later to men in general. He said female homosexuality developed when a girl loved her mother and identified with her father, and became fixated at that stage.[63][pageneeded]

Alfred Kinsey initiated the modern era of sex research. He collected data from questionnaires given to his students at Indiana University, but then switched to personal interviews about sexual behaviors. Kinsey and his colleagues sampled 5,300 men and 5,940 women. He found that most people masturbated, that many engaged in oral sex, that women are capable of having multiple orgasms, and that many men had had some type of homosexual experience in their lifetimes. Many[who?]believe he was the major influence in changing 20th century attitudes about sex. Kinsey Institute for Research in Sex, Gender, and Reproduction at Indiana University continues to be a major center for the study of human sexuality.[18][pageneeded]

Before William Masters, a physician, and Virginia Johnson, a behavioral scientist, the study of anatomy and physiological studies of sex was still limited to experiments with laboratory animals. Masters and Johnson started to directly observe and record the physical responses in humans that are engaged in sexual activity under laboratory settings. They observed 10,000 episodes of sexual acts between 312 men and 382 women. This led to methods of treating clinical problems and abnormalities. Masters and Johnson opened the first sex therapy clinic in 1965. In 1970, they described their therapeutic techniques in their book, Human Sexual Inadequacy.[full citation needed][18][pageneeded]

In the first edition of The Diagnostic and Statistical Manual of Mental Disorders, the American Psychiatric Association classified homosexuality as a mental illness, and more specifically, a "sociopathic personality disturbance".[78] This definition remained the professional understanding of homosexuality until 1973 when the American Psychiatric Association removed homosexuality from their list of diagnoses for mental disorders.[78] Through her research of heterosexual and homosexual men, Evelyn Hooker revealed that there was no correlation between homosexuality and psychological maladjustment,[79] and her findings played a pivotal role in shifting the scientific community away from the perspective that homosexuality was something that needed to be treated or cured.[citation needed]

European conquerors/colonists found sexuality out of their norm about 1516 when Vasco Nunez de Balboa, a Spanish explorer, discovered indigenous people in Central America with different sexual practices. Balboa found some indigenous men dressed up as women,[clarification needed] resulting in him feeding forty of these men to his dogs for having different sexual practices. In North America and the United States, Europeans have used claims of sexual immorality to justify discrimination against racial and ethnic minorities.[80][full citation needed]

Scholars also study the ways in which colonialism has affected sexuality today and argue that due to racism and slavery it has been dramatically changed from the way it had previously been understood.[81]

In her book, Carnal Knowledge and Imperial Power: Gender, Race, and Morality in Colonial Asia, Laura Stoler investigates how the Dutch used sexual control and gender-specific sexual sanctions to distinguish between the rulers from the ruled and enforce colonial domination onto the people of Indonesia.[82]

In America, there are 155 native tribes that are recorded to have embraced two-spirit people within their tribes, but the total number of tribes could be greater than what is documented.[83] Two-spirit people were and still are members of communities who do not fall under Western gender categories of male and female, but rather under a "third gender" category.[84] This system of gender contradicts both the gender binary and the assertion that sex and gender are the same.[85] Instead of conforming to traditional roles of men and women, two-spirit fill a special niche in their communities.

For example, two-spirited people are commonly revered for possessing special wisdom and spiritual powers.[85] Two-spirited people also can take part in marriages, either monogamous and polygamous ones.[86] Historically, European colonizers perceived relationships involving two-spirited people as homosexuality, and therefore believed in the moral inferiority of native people.[85] In reaction, colonizers began to impose their own religious and social norms on indigenous communities, diminishing the role of two-spirit people in native cultures.[87] Within reservations, the Religious Crime Code of the 1880s explicitly aimed to "aggressively attack Native sexual and marriage practices".[85] The goal of colonizers was for native peoples to assimilate into Euro-American ideals of family, sexuality, gender expression, and more.[85]

The link between constructed sexual meanings and racial ideologies has been studied. According to Joane Nagel, sexual meanings are constructed to maintain racial-ethnic-national boundaries by the denigration of "others" and regulation of sexual behavior within the group. She writes, "both adherence to and deviation from such approved behaviors, define and reinforce racial, ethnic, and nationalist regimes".[88][89] In the United States people of color face the effects of colonialism in different ways with stereotypes such as the Mammy, and Jezebel for Black women; lotus blossom, and dragon lady for Asian women; and the "spicy" Latina.[90] These stereotypes contrast with standards of sexual conservatism, creating a dichotomy that dehumanizes and demonizes the stereotyped groups. An example of a stereotype that lies at the intersection of racism, classism, and misogyny is the archetype of the welfare queen. Cathy Cohen describes how the "welfare queen" stereotype demonizes poor black single mothers for deviating from conventions surrounding family structure.[91]

Reproductive and sexual rights encompass the concept of applying human rights to issues related to reproduction and sexuality.[92] This concept is a modern one, and remains controversial since it deals, directly and indirectly, with issues such as contraception, LGBT rights, abortion, sex education, freedom to choose a partner, freedom to decide whether to be sexually active or not, right to bodily integrity, freedom to decide whether or not, and when, to have children.[93][94] These are all global issues that exist in all cultures to some extent, but manifest differently depending on the specific contexts.

According to the Swedish government, "sexual rights include the right of all people to decide over their own bodies and sexuality" and "reproductive rights comprise the right of individuals to decide on the number of children they have and the intervals at which they are born."[95] Such rights are not accepted in all cultures, with practices such criminalization of consensual sexual activities (such as those related to homosexual acts and sexual acts outside marriage), acceptance of forced marriage and child marriage, failure to criminalize all non-consensual sexual encounters (such as marital rape), female genital mutilation, or restricted availability of contraception, being common around the world.[96][97]

In 1915, Emma Goldman and Margaret Sanger,[98] leaders of the birth control movement, began to spread information regarding contraception in opposition to the laws, such as the Comstock Law,[99] that demonized it. One of their main purposes was to assert that the birth control movement was about empowering women with personal reproductive and economic freedom for those who could not afford to parent a child or simply did not want one. Goldman and Sanger saw it necessary to educate people as contraceptives were quickly being stigmatized as a population control tactic due to being a policy limiting births, disregarding that this limitation did not target ecological, political, or large economic conditions.[100] This stigma targeted lower-class women who had the most need of access to contraception.

Birth control finally began to lose stigma in 1936 when the ruling of U.S. v. One Package[101] declared that prescribing contraception to save a person's life or well-being was no longer illegal under the Comstock Law. Although opinions varied on when birth control should be available to women, by 1938, there were 347 birth control clinics in the United States but advertising their services remained illegal.

The stigma continued to lose credibility as First Lady Eleanor Roosevelt publicly showed her support for birth control through the four terms her husband served (19331945). However, it was not until 1966 that the Federal Government began to fund family planning and subsidized birth control services for lower-class women and families at the order of President Lyndon B. Johnson. This funding continued after 1970 under the Family Planning Services and Population Research Act.[102] Today, all Health Insurance Marketplace plans are required to cover all forms of contraception, including sterilization procedures, as a result of The Affordable Care Act signed by President Barack Obama in 2010.[103]

In 1981, doctors diagnosed the first reported cases of AIDS in America. The disease disproportionately affected and continues to affect gay and bisexual men, especially black and Latino men.[104] The Reagan administration is criticized for its apathy towards the AIDS epidemic, and audio recordings reveal that Ronald Reagan's press secretary Larry Speakes viewed the epidemic as a joke, mocking AIDS by calling it the "gay plague".[105] The epidemic also carried stigma coming from religious influences. For example, Cardinal Krol voiced that AIDS was "an act of vengeance against the sin of homosexuality", which clarifies the specific meaning behind the pope's mention of "the moral source of AIDS."[106]

Activism during the AIDS crisis focused on promoting safe sex practices to raise awareness that the disease could be prevented. The "Safe Sex is Hot Sex" campaign, for example, aimed to promote the use of condoms.[107] Campaigns by the U.S. government, however, diverged from advocacy of safe sex. In 1987, Congress even denied federal funding from awareness campaigns that "[promoted] or [encouraged], directly or indirectly, homosexual activities".[107] Instead, campaigns by the government primarily relied on scare tactics in order to instill fear in men who had sex with other men.[107]

In addition to prevention campaigns, activists also sought to counteract narratives that led to the "social death" for people living with AIDS.[108] Gay men from San Francisco and New York City created the Denver Principles, a foundational document that demanded the rights, agency, and dignity of people living with AIDS.[108]

In his article "Emergence of Gay Identity and Gay Social Movements in Developing Countries", Matthew Roberts discusses how international AIDS prevention campaigns created opportunities for gay men to interact with other openly gay men from other countries.[109] These interactions allowed western gay "culture" to be introduced to gay men in countries where homosexuality wasn't an important identifier. Thus, group organizers self-identified as gay more and more, creating the basis for further development of gay consciousness in different countries.[109]

In humans, sexual intercourse and sexual activity in general have been shown to have health benefits, such as an improved sense of smell,[citation needed] reduction in stress and blood pressure,[110][111] increased immunity,[112] and decreased risk of prostate cancer.[113][114][115] Sexual intimacy and orgasms increase levels of oxytocin, which helps people bond and build trust.[116][117][118]

A long-term study of 3,500 people between ages 30 and 101 by clinical neuropsychologist David Weeks, MD, head of old-age psychology at the Royal Edinburgh Hospital in Scotland, said he found that "sex helps you look between four and seven years younger", according to impartial ratings of the subjects' photographs. Exclusive causation, however, is unclear, and the benefits may be indirectly related to sex and directly related to significant reductions in stress, greater contentment, and better sleep that sex promotes.[119][120][121]

Sexual intercourse can also be a disease vector.[122] There are 19 million new cases of sexually transmitted diseases (STD) every year in the U.S.,[123] and worldwide there are over 340 million STD infections each year.[124] More than half of these occur in adolescents and young adults aged 1524 years.[125] At least one in four U.S. teenage girls has a sexually transmitted disease.[123][126] In the U.S., about 30% of 15- to 17-year-olds have had sexual intercourse, but only about 80% of 15- to 19-year-olds report using condoms for their first sexual intercourse.[127] In one study, more than 75% of young women age 1825 years felt they were at low risk of acquiring an STD.[128]

People both consciously and subconsciously seek to attract others with whom they can form deep relationships. This may be for companionship, procreation, or an intimate relationship. This involves interactive processes whereby people find and attract potential partners and maintain a relationship. These processes, which involve attracting one or more partners and maintaining sexual interest, can include:

Sexual attraction is attraction on the basis of sexual desire or the quality of arousing such interest.[135][136] Sexual attractiveness or sex appeal is an individual's ability to attract the sexual or erotic interest of another person, and is a factor in sexual selection or mate choice. The attraction can be to the physical or other qualities or traits of a person, or to such qualities in the context in which they appear. The attraction may be to a person's aesthetics or movements or to their voice or smell, besides other factors. The attraction may be enhanced by a person's adornments, clothing, perfume, hair length and style, and anything else which can attract the sexual interest of another person. It can also be influenced by individual genetic, psychological, or cultural factors, or to other, more amorphous qualities of the person. Sexual attraction is also a response to another person that depends on a combination of the person possessing the traits and also on the criteria of the person who is attracted.

Though attempts have been made to devise objective criteria of sexual attractiveness, and measure it as one of several bodily forms of capital asset (see erotic capital), a person's sexual attractiveness is to a large extent a subjective measure dependent on another person's interest, perception, and sexual orientation. For example, a gay or lesbian person would typically find a person of the same sex to be more attractive than one of the other sex. A bisexual person would find either sex to be attractive.

In addition, there are asexual people, who usually do not experience sexual attraction for either sex, though they may have romantic attraction (homoromantic, biromantic or heteroromantic). Interpersonal attraction includes factors such as physical or psychological similarity, familiarity or possessing a preponderance of common or familiar features, similarity, complementarity, reciprocal liking, and reinforcement.[137]

The ability of a person's physical and other qualities to create a sexual interest in others is the basis of their use in advertising, music video, pornography, film, and other visual media, as well as in modeling, sex work and other occupations.

Globally, laws regulate human sexuality in several ways, including criminalizing particular sexual behaviors, granting individuals the privacy or autonomy to make their own sexual decisions, protecting individuals with regard to equality and non-discrimination, recognizing and protecting other individual rights, as well as legislating matters regarding marriage and the family, and creating laws protecting individuals from violence, harassment, and persecution.[138]

In the United States, there are two fundamentally different approaches, applied in different states, regarding the way the law is used to attempt to govern a person's sexuality. The "black letter" approach to law focuses on the study of pre-existing legal precedent, and attempts to offer a clear framework of rules within which lawyers and others can work.[138] In contrast, the socio-legal approach focuses more broadly on the relationship between the law and society, and offers a more contextualized view of the relationship between legal and social change.[138]

Issues regarding human sexuality and human sexual orientation have come to the forefront in Western law in the latter half of the twentieth century, as part of the gay liberation movement's encouragement of LGBT individuals to "come out of the closet" and engaging with the legal system, primarily through courts. Therefore, many issues regarding human sexuality and the law are found in the opinions of the courts.[139]

While the issue of privacy has been useful to sexual rights claims, some scholars have criticized its usefulness, saying that this perspective is too narrow and restrictive. The law is often slow to intervene in certain forms of coercive behavior that can limit individuals' control over their own sexuality (such as female genital mutilation, forced marriages or lack of access to reproductive health care). Many of these injustices are often perpetuated wholly or in part by private individuals rather than state agents, and as a result, there is an ongoing debate about the extent of state responsibility to prevent harmful practices and to investigate such practices when they do occur.[138]

State intervention with regards to sexuality also occurs, and is considered acceptable by some, in certain instances (e.g. same-sex sexual activity or prostitution).[138]

The legal systems surrounding prostitution are a topic of debate. Proponents for criminalization argue that sex work is an immoral practice that should not be tolerated, while proponents for decriminalization point out how criminalization does more harm than good. Within the feminist movement, there is also a debate over whether sex work is inherently objectifying and exploitative or whether sex workers have the agency to sell sex as a service.[140]

When sex work is criminalized, sex workers do not have support from law enforcement when they fall victim to violence. In a 2003 survey of street-based sex workers in NYC, 80% said they had been threatened with or experienced violence, and many said the police were no help. 27% said they had experienced violence from police officers themselves.[141] Different identities such as being black, transgender, or poor can result in a person being more likely to be criminally profiled by the police. For example, in New York, there is a law against "loitering for the purpose of engaging in prostitution", which has been nicknamed the "walking while trans" law because of how often transgender women are assumed to be sex workers and arrested for simply walking out in public.[142]

In some religions, sexual behavior is regarded as primarily spiritual. In others it is treated as primarily physical. Some hold that sexual behavior is only spiritual within certain kinds of relationships, when used for specific purposes, or when incorporated into religious ritual. In some religions there are no distinctions between the physical and the spiritual, whereas some religions view human sexuality as a way of completing the gap that exists between the spiritual and the physical.[143]

Many religious conservatives, especially those of Abrahamic religions and Christianity in particular, tend to view sexuality in terms of behavior (i.e. homosexuality or heterosexuality is what someone does) and certain sexualities such as bisexuality tend to be ignored as a result of this.[citation needed] These conservatives tend to promote celibacy for gay people, and may also tend to believe that sexuality can be changed through conversion therapy[144] or prayer to become an ex-gay. They may also see homosexuality as a form of mental illness, something that ought to be criminalised, an immoral abomination, caused by ineffective parenting, and view same-sex marriage as a threat to society.[145]

On the other hand, most religious liberals define sexuality-related labels in terms of sexual attraction and self-identification.[144] They may also view same-sex activity as morally neutral and as legally acceptable as opposite-sex activity, unrelated to mental illness, genetically or environmentally caused (but not as the result of bad parenting), and fixed. They also tend to be more in favor of same-sex marriage.[145]

According to Judaism, sex between man and woman within marriage is sacred and should be enjoyed; celibacy is considered sinful.[18][pageneeded]

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Human sexuality

A tiny particle collider yields new evidence for a type of ‘quasiparticles’ called anyons – Massive Science

The president has had a life-threatening, infectious disease for over a week, and he and his doctors havent been very transparent about the timeline and course of his affliction. In lieu of detailed disclosures, reporters have to piece together his condition based on the treatments hes been receiving.

Trump was started off on an experimental therapeutic an antibody cocktail and then advanced to another remdesivir. The other biomolecules coursing through Donald Trump's system (and this week's headlines) are corticosteroids, called dexamethasone.

You may have heard of cytokine storms, where the body's immune response to severe COVID-19 bombards healthy cells, making the illness worse. Trump has been given dexamethasone, an immuno-supressant that doctors prescribe to temper that effect. Unlike the other experimental treatments, dexamethasone is common and somewhat easy to access. However, it is rarely administered to a patient with a case as (self-)reportedly mild as Donald Trumps. In an interview with New York Magazine's Intelligencer, the co-author of a recent study testing dexamethasone elaborates:

That lack of evidence is concerning as Trump heads into a critical point in the course of his illness. COVID-19 is known for being a bit of a roller coaster, with intermittent fevers, mysterious symptoms, and rapid declines. Abraar Karan, a physician with experience treating patients with COVID-19, told Monique Brouillette at Scientific American that some people have turned corners and left the hospital, only to come back feeling much sicker, with even worse oxygen levels and possibly other harm to the bodys organs.

It is theoretically possible that the early steroid treatment may ward off a dangerous auto-inflammatory reaction. But beyond the inherent risks of immuno-supression, corticosteroids may also cause behavioral side effects in the President. Trump's cognitive and behavioral state has been a point of concern for years. Potent steroids such as dexamethasone are known to increase appetite, decrease restful sleep, and bring about heightened "maniacal" energy states.

As the nation enters the weekend, Speaker of the House Nancy Pelosi is rolling out a 25th amendment commission, Trump is boasting a miraculous recovery with a Fox News doctor, and the rest of us continue to wait and learn how biology will run its course. For better or worse, the side effects our president experiences may prove to have historical consequences. To my knowledge, roid rage has never been a factor in nuclear geopolitics.

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A tiny particle collider yields new evidence for a type of 'quasiparticles' called anyons - Massive Science

A pathway to nowhere? A critique of the National Academy of Sciences report on genome editing – BioNews

12 October 2020

Research Fellow in Biomedical Ethics, University of Melbourne/Murdoch Children's Research Institute

The transformative impact of CRISPR/Cas9 genome editing was recognised last week, with the Nobel Prize being awarded to its founders Jennifer Doudna and Emmanuelle Charpentier.

Since the prize winners first described this new approach to editing DNA, CRISPR has been used for hundreds of applications in biological research, agriculture, conservation biology and somatic medicine. However, its most controversial use has been in human reproduction, a practice called heritable genome editing (HGE). In 2018 Dr He Jiankui, an associate professor at the Southern University of Science and Technology in China announced he had used CRISPR to edit the CCR5 gene in embryos, resulting in twins who had already been born (see BioNews 997). The goal was to make the children resistant to infection from HIV.

Dr He Jiankui's announcement shocked the world and was condemned as a great violation of research ethics. In response, the US National Academy of Medicine, the US National Academy of Sciences, and the UK's Royal Society formed an 'International Commission on the Clinical Use of Human Germline Genome Editing' with the goal of 'defining a responsible pathway for clinical use of human HGE (HHGE), should a decision be made by any nation to permit its use' (see BioNews 1000). The outputs are a list of 11 recommendations that states should follow should they wish to implement HGE.

The strength of the report is the great detail it gives about the technical progress that has been made with genome editing technologies, their current limitations, and the hurdles such technologies should meet before we proceed to clinical applications. The report makes important general points like the need to engage with diverse communities likely to be affected by HGE.

However, in this article, I wish to discuss two reasons to be critical of the report. One concerns its framing and general relevance. The other is the way it categorises different possible future applications of HGE.

Framing and relevance

A convincing need for a clinical pathway for HGE is not provided in the Commission's report. The actions of Dr Jiankui, which were its catalyst, did not challenge our traditional clinical pathways. Dr Jiankui was a rogue actor, who took steps to hide what he was doing from others. His actions were incompatible with basic research ethics principles and existing guidelines for germline genome editing. If the goal is to prevent repeat actors like Dr Jiankui, we need to focus on compliance with existing standards rather than developing new ones.

Furthermore, if a specific clinical pathway for HGE is warranted, it's not clear why you would attempt to define one now. We are still far from having enough evidence to establish the safety of HGE. This will likely remain the case for some time, given restrictions on research in many places. Furthermore, HGE remains illegal in many parts of the world, including the USA, Europe, and the UK. No countries have announced intentions to relax laws and allow HGE, and China has recently passed legislation to restrict it. While the Commission's report is useful for suggesting some safety hurdles that must be cleared (for example recommendations five and six), the fact that we are so far from doing so raises questions about the need for further recommendations. Why not wait until we have safe technologies that some countries are considering implementing before devising detailed clinical pathways? As knowledge of the opportunities and risks posed by HGE increases, a pathway that is currently appropriate for HGE may well be obsolete in the future.

Categorising different applications

To further the above criticism, consider the six categories of HGE applications the Commission's report distinguishes:

A: Cases in which all of the prospective parents' children would inherit the disease-causing genotype for a serious monogenic disease (defined in this report as a monogenic disease that causes severe morbidity or premature death).

B: Cases in which some but not all of the prospective parents' children would inherit the pathogenic genotype for a serious monogenic disease.

C: Cases involving other monogenic conditions with less serious impact.

D: Cases involving polygenic diseases.

E: Cases involving other applications of HGE, including changes that would enhance or introduce new traits or attempt to eliminate certain diseases from the human population.

F: The special circumstance of monogenic conditions that cause infertility.

The Commission considers that only applications in Category A and some in Category B qualify for a clinical pathway. It's no doubt true that the most likely and logical initial application for HGE will be to prevent a serious monogenic disease, in cases where there are no other options. However, it's not clear whether other applications might become more compelling in the future, or indeed if there is a need to draw distinctions like this at all.

Consider how the report deals with applications to prevent infectious disease: a timely application considering we are currently experiencing a pandemic. Applications of HGE which gives individuals resistance to infectious disease are placed in Category E the same category as genes which enhance normal traits like intelligence. We are told a responsible clinical pathway cannot be defined for this application. But consider the following hypothetical case:

A new infectious disease Cebola has become endemic in some parts of the world, and no vaccine is available. Many die of Cebola in childhood. By altering one base-pair, it is possible to make children immune to Cebola. Base editing technologies are developed which can make these changes precisely, with no other changes made in the genome. It is possible to make individuals immune to Cebola by editing embryos used in IVF or editing men's spermatogonial stem cells.

Although such an application of HGE is unlikely, who knows what the world will be like by the time HGE is safe. The fact that this application is classed by the Commission's report in the same category as one which enhances intelligence is problematic, in my view. What is important is whether an application is safe and is expected to do good and prevent harm it doesn't matter ethically whether the harm would have been caused by an inherited disease or an infectious disease. What I think this shows is the need to assess HGE on an application by application basis, and not draw arbitrary distinctions far ahead of time.

Too many reports?

The Commission's report is the latest of dozens into genome editing and will be followed by another by the World Health Organisation soon. What often gets overlooked in these reports is the existing barriers to basic research into genome editing in germ cells, which is illegal or unfeasible in many parts of the world. If our goal is to use HGE to prevent the death and harm caused by genetic disease, we should be focusing on defining pathways that make responsible research easier around the world, rather than prematurely describing clinical pathways.

Read more:
A pathway to nowhere? A critique of the National Academy of Sciences report on genome editing - BioNews

Superficial white matter imaging: Contrast mechanisms and whole-brain in vivo mapping – Science Advances

Superficial white matter (SWM) contains the most cortico-cortical white matter connections in the human brain encompassing the short U-shaped association fibers. Despite its importance for brain connectivity, very little is known about SWM in humans, mainly due to the lack of noninvasive imaging methods. Here, we lay the groundwork for systematic in vivo SWM mapping using ultrahigh resolution 7 T magnetic resonance imaging. Using biophysical modeling informed by quantitative ion beam microscopy on postmortem brain tissue, we demonstrate that MR contrast in SWM is driven by iron and can be linked to the microscopic iron distribution. Higher SWM iron concentrations were observed in U-fiberrich frontal, temporal, and parietal areas, potentially reflecting high fiber density or late myelination in these areas. Our SWM mapping approach provides the foundation for systematic studies of interindividual differences, plasticity, and pathologies of this crucial structure for cortico-cortical connectivity in humans.

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Superficial white matter imaging: Contrast mechanisms and whole-brain in vivo mapping - Science Advances

Detained migrants susceptible to a range of reproductive abuses and medical neglect – University of Rochester

September 22, 2020

The history of eugenics in the United States leaves todays migrant women vulnerable, arguesBrianna Theobald, an assistant professor of history at theUniversity of Rochester, in aWashington PostMade by History op-ed.

Theobald writes in response to a whistleblower complaint, one claiming that a migrant detention facilitythe Irwin County Detention Centerhas been the site of egregious reproductive injustices,including alleged coerced hysterectomies.

The author of Reproduction on the Reservation: Pregnancy, Childbirth, and Colonialism in the Long Twentieth Century(University of North Carolina Press, 2019), Theobald argues that the structural vulnerability of detained migrants leaves them susceptible, as has historically been the case for many marginalized communities, to a range ofreproductive abuses, as well as to medical neglect and inadequate care.

According to Theobald, these alleged abuses occur in systems that are driven by dangerous ideas about racial hierarchies and eugenic interventions. She writes that todays allegations of coerced hysterectomies and sterilization echo the history of eugenics and neo-eugenics, noting that:

Prominent eugenicist Charles Davenport defined the practice of eugenics as the science of the improvement of the human race by better breeding.Eugenics gained popularity in the United States in the early 20th century, appealing broadly across the political spectrum because it promised a scientific solution to social problems stemming from industrialization, urbanization, immigration and changing gender norms.

Theobald further explains the now-discredited notion of eugenics: The theory held the human race could be improved by encouraging the reproduction of fit individuals, specifically the white middle-class families whose declining fertility rates had become the source of much anxiety, and discouraging the reproduction of individuals believed to possess undesirable traits.

She then outlines several cases of sterilization targeting marginalized populations in US history, including ontheCrow Reservation in Montana in the 1930s and in California prisons during the late 1990s and early 2000s, while highlighting the ongoing work of the reproductive justice movement.

Tags: Arts and Sciences, Brianna Theobald, Department of History

Category: Voices & Opinion

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Detained migrants susceptible to a range of reproductive abuses and medical neglect - University of Rochester

What are the wider implications of Covid-19 on our overlooked health services? – TheJournal.ie

THE THIRD WAVE of the pandemic has hit the country harder than could have been imagined, bringing an already stretched health service to breaking point.

Unwelcome records have been broken within the first weeks of the new year, with deaths, cases and numbers in ICU rocketing as frontline staff work around the clock to quell the rising storm.

As staff and resources are again pooled to tackle the latest string of admissions, a host of other services and procedures have been postponed at hospitals across the country.

While attention has been put on elective or non-urgent surgeries or consultant appointments deferred, this month the team at our community-led investigative platform, Noteworthy decided to take a closer look at the impact that Covid-19 is having on services flying under the radar.

We discovered that, among other areas, the crisis has exacerbated a long-term lack of adequate support in emergency psychiatric care, eating disorder services, and for the roll-out of publicly funded IVF treatment.

Emergency mental health services at breaking point

One area that has a need for more support and resources, according to Mater Hospital psychiatrist Anne Doherty, is specialist mental health teams in emergency departments (EDs).

Last month, Dr Doherty explained to us that they are the new frontline in mental health care but are now at a breaking point due to years of underfunding and a lack of hospital beds for psychiatric care.

The data would appear to bear this out. Today, we have just 22 acute public mental health beds per 100,000 population, compared with the EU average of 70 per 100,000.

Services are also underfunded compared to EU colleagues, receiving around 6% of our healthcare budget compared with 10 to 13% in the UK, France, Germany, Sweden and the Netherlands.

The Noteworthy team wants to investigate the measures being taken to tackle a pandemic-induced mental health crisis in Ireland. You can support this project here.

Failed by the health system

A bid to shore up some of the gaps in general mental health funding during the pandemic has, in turn, highlighted serious failings in other areas, including support for people with eating disorders.

As we revealed last month, the entire amount of last years development funding for eating disorder services was used to cover other areas of mental health provision.

This is not the first year funding failed to match the States promised spend. To date, just 137,000 (3.4%) of 4 million in development funding for eating disorders has been spent since 2018.

This lack of support has taken a toll, with several people with eating disorders, parents and medical professionals all contacting us about their struggles with the current system.

A letter to Noteworthy from one parent summed up the frustration of families trying to get the required medical attention for their loved ones:

This is just one of the personal stories that we want to highlight in our proposed Silent Treatment investigation to find out if people with eating disorders are being failed by the public health system. You can find out more details on how you can support this work here.

Funding Fertility

The frustration of various couples has also been expressed to us in recent months about another long overlooked but vitally important area infertility treatment.

Almost one in six couples in Ireland face fertility difficulties, leaving many to face thousands in costs for assisted human reproduction treatment, as they wait on public funding to support those undergoing fertility treatment, first announced in 2017.

This has led many people to travel overseas for cheaper fertility treatment something that the pandemic has impacted and as we showed last month, there continue to be long delays in the roll out of a public model.

According to Health Minister Stephen Donnelly, the development of planned regional fertility hubs has slowed due to the management of the Covid-19 pandemic. In addition, the Department of Health confirmed to us that it cannot provide a concrete timeline for rollout of publicly-funded IVF.

Rory Tallon, who has cystic fibrosis and underwent IVF with his wife Sarah before the birth of each of their two daughters,told us that the cost of treatmentwas comparable to the cost of a wedding or house deposit.

Emma McDade, who is currently undergoing fertility treatment, wrote an opinion piece for us recently where she called for promised regulation of the sector, citing costly tests and extra add-ons. She gave an example of a blood test which cost five times more in the clinic compared to her local GP office.

We want to shine a spotlight on this issue and examine if these long delays in publicly funding IVF has destroyed some peoples chance to have children. Here is how you can support this work.

How to help

You can also helpNoteworthyin a few other ways:

To find out how contributions are used, or anything else about howNoteworthyworks, clickhere. You can also sign up to ourInsider Newsletteror find us onTwitterandFacebook. If you have any questions or suggestions, feel free to email information@noteworthy.ie

Thanks so much for your continued support!

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What are the wider implications of Covid-19 on our overlooked health services? - TheJournal.ie

The world of mushrooms | Opinion | coastalview.com – Coastal View News

As the hope and promise of winter rain grows, I look forward to the season of mushroom hunting. While the semi-arid climate of southern California isnt as famous for mushroom hunting as the lush rainforests of the Pacific Northwest or the rainy redwoods of Northern California, there are still plenty of fungal treasures to discover in the oak woodlands and coastal sage scrub of the front range once rain arrivesif you practice a keen eye and patience.

Mushrooms are the fruiting bodies of underground mycelial webs which knit the world together. They are the visible, often delicious aboveground manifestation of subterranean fungal networks comprised of threadlike, hollow tubes called hyphae. Mushrooms emerge briefly, triggered by rain and humidity, to cast fungal spore into the wind for reproduction. Even after mushrooms release their spore to the wind and disappear the fungal webs from which they came persist for generations, sending up new fruiting bodies every rainy season.

Despite their reliance on humid climates, fungi thrive throughout the world from the Arctic Circle to the Mojave Desert. In fact, fungal networks are a critical component to the soil ecology of arid landscapes, including those of inland California. Fungi are long-lived and can grow to enormous proportions. The largest known organism on Earth is a honey mushroom in Oregon whose mycelial web underpins almost 2400 acres of the Malheur National Forest.

Fungi are essential to life on Earth. They are primary decomposers of decaying matter, recycling spent, dead and dying material into organic, fertile soil capable of growing carbon-storing forests, lush river valleys and rich fields for human agriculture. Because of their ability to break things down, fungi play a central role in the growing science of bioremediation, as humans begin to confront and repair ecosystems damaged with plastic litter, agricultural poisons, nuclear waste and chemical and oil spills. Fungi show incredible promise in returning these intractable-seeming waste streams into harmless environmental elements. Amazingly, in one recent experiment scientists grew oyster mushrooms out of plastic waste in just a few short months, reducing waste volume by 80% while producing edible oyster mushrooms.

Fungi are one of the most mysterious kingdoms of life on Earth. Scientists estimate that at least 90% of fungus species remain unknown and undocumented, despite their everyday importance in our lives. One of the most interesting developments in mycology (another word for fungus) research is that of mapping communication networks spanning the underground webs of fungal organisms and trees and plants within forest communities.

Recent research reveals that fungi are constantly communicating via electrical and chemical signals, and that different branches of the same fungal network spread over a vast space are capable of sharing nutrients with depleted areas of the network. Fungi also seem to facilitate a similar sharing of resources within separate, distinct trees and plants in old-growth forest communities. For example, scientists have shown through peer-reviewed field experiments that forest trees warn one another of insect pests, herbivore predations and toxic shifts in the physical environment, allowing surrounding trees to mount chemical defenses. In addition, mature trees dying of old age will share their remaining nutrient stores with younger, smaller trees nearby before their demise. Scientists speculate that much of this communication and chemical sharing is enabled by the fungal networks that span healthy, diverse forests, connecting trees to one another.

This research is groundbreaking because it calls into question one of the basic premises of evolutionary biology: survival of the fittest or the belief that life on Earth is a constant battle for limited resources. While the critical science of this work is still emergent, early conclusions drawn from decades of fieldwork provide a hopeful and helpful alternative moral compass for our human community as well, predicated on communication, resource-sharing and cooperation for the betterment of the whole.

This work underlines how little we still understand about the complexity and interdependence of old-growth habitats.

Much of the recent work on mycelial webs within forests was triggered by foresters who realized that the replanting of logged forests with a single species of trees wasnt working. Despite extra water and care, young trees were unable to survive in clear cut landscapes. Current scientific thought points to the fact that logged landscapes often cause the erosion and degradation of the recently-exposed soil surface, which damages or kills the fungal network partly responsible for feeding and nurturing young trees, to the detriment of replanted monocultures.

I wrote an article this September on the Forest Services proposal to log old growth pine forests in our backcountry backyard along the Pine Mountain ridgeline. Perhaps sciences growing recognition of the interconnection and interdependence of seemingly disparate wild lives is another caution against such a proposal.

Alena Steen is coordinator of the Carpinteria Garden Park, an organic community garden located at 4855 5th St., developed by the citys Parks and Recreation Department.Community members rent a plot to grow their own fresh produce. For more information, visit carpinteria.ca.us/parks-and-recreation or contact Alena at alenas@ci.carpinteria.ca.us.

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The world of mushrooms | Opinion | coastalview.com - Coastal View News

Legal but not accessible: abortion in Turkey from an ethical perspective – DiEM25

As has been reported by Amnesty International, Around 47,000 women die as a result of unsafe abortions every year. The testimony of Rajat Khosla, Amnesty Internationals Senior Director of Research and Advocacy shows the peril of the siege over womens bodies. Although the political authorities try to establish their presence under the subject of religious sensitivity with the slogan that abortion is murder, many women have died as a result of the operations carried out under improper conditions.

In countries where abortion is restricted or prohibited, women who are wealthy have the chance to get an abortion abroad and return to their countries, while the poor have to terminate their pregnancy using dangerous methods such as clothes hangers, as in Argentina.

In this context, it is not possible for women especially those that are struggling economically to make decisions about their own body and implement them under safe conditions.

Abortion debates get even more intensified when we consider how governments perceive womens bodies as a medium of capitalist reproduction (as described in Marxian Economics) and try to intervene in womens bodily integrity using religion as a pretext.

From the most conservative countries to the most modern ones, anti-abortion creates authority over the female body, albeit in different doses. By denying that abortion is a human right to bodily integrity, the abortion process is blocked by regulatory laws.

The access to abortion has been limited even in countries where abortion is legal. Abortion centers are being reserved for COVID-19 patients, pre-appointments are difficult when clinics are open, and the prohibition of abortion is expressed louder than ever.

In Turkey, where abortion is legal; anti-abortion policies have been implemented since the first years of the Republic. Especially after World War I, using the decrease in the population ratio as an excuse, parents were incentivised to have children. There was also a period during which having access to contraception methods and pregnancy termination were made difficult. The legal consequences of having an abortion was stated as imprisonment and fines. With an amendment made in 1938, under the title of Crimes Against the Unity of the Race and Health, abortion was even named a betrayal of Turkishness .

With the Law on Population Planning No. 2827, which became effective in 1983, it was stated that one can decide to get an abortion until the tenth week of pregnancy, and the abortion ban was abolished. Under the same law, arbitrary abortion is subject to the consent of the spouse if the pregnant woman is married, and the permission of the parent if the pregnant woman is a minor.

Especially after the AKP (Justice and Development Party) came to power, the abortion opposition was used as a means of consolidating society with the statement that the duty of women is motherhood by nature. I see abortion as murder, nobody should have the right to allow this stated AKP president, Recep Tayyip Erdogan in 2012 reflecting a patriarchal perception, and creating a period during which pressures on women have increased and abortion has become virtually prohibited.

Although abortion is a legal right in Turkey, there are certain situations in which abortions are not performed in public and even certain private hospitals unless it is deemed a medical necessity. Indeed, there remain obstacles to abortion; abortions are left to the doctors initiative, abortion appointments are given weeks after the request, and there is pressure against hospitals that perform abortions. Due to this, women experience shame and trauma when they return home.

According to the Abortion Services in State Hospitals report published by Kadir Has University in 2016; in 53 out of 81 provinces, there are no hospitals that provide abortion services on demand.

In an environment where abortion is de facto banned, we are also experiencing a period during which assistive mechanisms of contraception methods have decreased, and women have to face an increase of unwanted pregnancies.

The common feature of governments that try to make abortion illegal is that they oppose gender equality and clearly state this. Trump being the first US president to participate in anti-abortion actions in the USA, the recent discussion in Poland on abortion ban, the emphasis on political Islam in Turkey, supporting that women and men cannot be equal and that the sacred duty of women is to bear children, while discussions about the withdrawal from the Istanbul Convention are going on, show that the capitalist and patriarchal mentality is imposing its hegemony all over the planet.

The continuous subjection to violence, the disregard for domestic labor, marginalization in working life, exposure of immigrant women to pressure during and after migration are only some of the reflections of the efforts to put women in their place.

We will either live the life they try to convict us of, or build our future right from where the Dominican Mirabal sisters started, from who we inherited the International Day for the Elimination of Violence against Women on 25 November.

In the words of Margaret Atwood:

There isnt the future that were doomed to enact. There are all kinds of possible futures. And which one were going to get is going to depend on what we do now.

Right now, our sisters are defending their civil liberties and right to bodily autonomy in the streets against patriarchys domination over women all around the world.

We will not allow any government or sexist mentality to hide the discriminations they created by using womens bodies as a token on which they base political rhetoric and action.

We will increase our solidarity with women, LGBTQIA+ individuals, and all who are oppressed by patriarchy and capitalism. We will fight collectively for our present and future, against the darkness, and in doing so create a butterfly effect. We will fight against the darkness of patriarchy, which threatens to lock us in our houses and turn our bodies into a vessel for reproduction.

Photo Source: Daily Beast.

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Legal but not accessible: abortion in Turkey from an ethical perspective - DiEM25

‘It’s a huge source of stress’: Women going abroad for IVF hit out at mixed messages over travel restrictions – TheJournal.ie

THE GOVERNMENTS MIXED messaging on travel abroad has been criticised by people who need to travel overseas for fertility treatment.

Many people choose to travel to elsewhere in Europe for treatment because the process can be thousands of euro cheaper than in Ireland.

However, people are concerned about the impact Covid-19 travel restrictions, and flights being cancelled, could have on their treatment.

Some people are missing appointments or choosing to delay their treatment, but this is not an option for others particularly if age is an issue.

There has also been a lack of clarity on what is deemed essential medical treatment for travel purposes, and how long a person has to restrict their movements for when they return to Ireland after undergoing a medical procedure abroad.

Emma*, who lives in Dublin, began IVF treatment in Prague in the Czech Republic during the week. She said the process of undergoing fertility treatment is stressful enough without the added worry of travel restrictions and lack of clarity on what people should do.

She believes IVF is an essential journey, but said the governments messaging on travel has been lacking.

Im on a few social media groups for people getting IVF and everyone seems really confused.

We are allowed to travel abroad, but what is not clear and seems to be causing a lot of confusion for people, is the phase of restriction of movement.

Do we still have to restrict our movements when returning from treatment? My reading of [the guidelines] would be that if I was an essential worker like a high-level engineer, I would not have to restrict movements coming into Ireland, so is it the same for us?

Emma is currently taking two weeks of unpaid leave from work so she can self-isolate as a precaution.

TheJournal.ie asked Chief Medical Officer Dr Tony Holohan at Thursdays Covid-19 briefing if IVF is deemed an essential medical reason to travel, and how long people should restrict their movements for when they return to Ireland.

He replied: I would hope that anybody in that situation is under the care and direction of a consultant or clinician in this country who would be perfectly well able to understand not just the public health advice, but how it should apply to a particular individual in a particular clinical context.

And if an individual is worried or concerned about what advice they should be following they should speak to their own consultants.

Holohan said clinicians in Ireland will understand and interpret public health advice and provide that to an individual who need individualised advice about their specific circumstances.

So anybody in this situation, who is seeking treatment outside of the country, I would hope thats under the direction of a clinician in this country, to whom they should speak about how best to protect themselves and manage the risks that might arise for them.

Many of the people who undergo fertility treatment abroad, including Emma, are not under the care of a consultant here.

TheJournal.ie sought further clarification from the Department of Health and the Department of Transport on the issue.

A DOH spokesperson said this: Decisions as to what constitutes essential reasons for medical travel have to be judged on an individual clinical basis. If an individual is concerned about what advice they should be following, they should speak to their own consultants.

The governments latest travel advice can be read here.

PCR test

It was confirmed during the week that from midnight on 29 November, under new guidelines, travellers arriving into Ireland from so-called red regions in the EU (most European countries) can move freely once they pass a PCR Covid-19 test five days following their arrival.

This provision will also be available to arrivals from orange regions who may not have availed of a pre-departure test. You can read more about the traffic light system here.

Obviously, the new guidelines this week were welcome but they wont apply to me this time. What Covid brings to everyone is uncertainty and that includes those of us doing IVF, Emma said.

When she has to revisit Prague in a few months, Emma said she will try to get a PCR test when she returns but, even if it is negative, her employers have said she will likely be unable to work as she deals with the public every day so they dont want to take that risk. She works as a contractor and will need to take more unpaid leave.

File photo Source: Shutterstock/Africa Studio

Helen Browne, co-founder of the National Infertility Support and Information Group (NISIG), said other women are in the same position as Emma.

Its very very tough on people at the moment with Covid-19, she told TheJournal.ie.

Browne said some people will want to keep the fact they are undergoing fertility treatment abroad private, but those who are upfront with their boss often have to take unpaid leave.

Some women will be able to use holiday leave, but this isnt always an option.

Its very difficult to get paid leave, the employer will probably say it has to be unpaid leave, rather than giving them paid leave, Browne said.

They have two weeks of wage or salary not given to them, an added expense on top of everything that theyre going through.

Some women who undergo fertility treatment abroad attend a clinic that is linked to a clinic in Ireland, but many do not have a clinician based here.

A lot of them go independently, she said, so they cant consult with a doctor here about what they should do in terms of restricting their movements.

Browne said people want more clarity on the right thing to do.

She said shes aware of women having to stay abroad for longer than they typically would because of reduced flights.

They now have to stay for about a week, rather than two or three days, because of the reduced flights. Theyre actually having to pay more money for accommodation.

Normally if theyre going abroad for a few days, their partner would go with them. But now because the partner cant take a week off, most likely cant take two weeks off, they cant go with them. Its really tough all round, theyre all on their own over there as well.

Time is a factor

Its hard to get an accurate figure of how many people from Ireland travel abroad for fertility treatment each year but its believed to be in the hundreds.

Most people choose to go to the Czech Republic, Browne noted, but others go to countries such as Spain.

She said some people have chosen to delay their treatment but that this is not an option for everyone.

Unfortunately, some people that go abroad for treatments are told that their ovarian reserve is dropping, and they feel now that they can go.

By the time they get a chance to go, theyll have no choice but to go for donor egg. Whereas they would like to have the opportunity of using their own eggs before they embark on donor eggs if they have to.

If somebody said to me, Im 39 now and by the time I get to go Ill be 40, by the time I had my baby, if Im lucky, Ill be 41. Thats two years added on.

The older a woman is when she becomes pregnant, the higher the risk in terms of complications, and many people need more than one round of IVF to become pregnant.

Its a huge undertaking

During IVF, mature eggs are collected from ovaries and fertilised by sperm in a lab. The fertilised egg or eggs are transferred into the uterus.

One full cycle of IVF takes about three weeks, but can take longer. It may take several rounds of IVF sometimes over the course of years and costing tens of thousands of euro for a person to become pregnant, if its successful.

When you decide to do IVF at all its a huge undertaking, physically, emotionally and of course financially, Emma told us.

She said she made the decision to undergo IVF before the Covid-19 pandemic and, over the course of the first lockdown, decided to go abroad for financial reasons.

We decided to do IVF earlier this year but could not get over the cost of it in Ireland. While saving for a house it just seemed completely out of reach financially.

Emma did some research online and joined a number of social media support groups, and found out that Prague seemed to be a place that was affordable and also offered a good medical service.

We knew it would be a risk and would mean I would be travelling alone a lot of the time, but when your heart is set on starting a family, youll push and push until you find a way.

Emma said the Irish government should fund fertility treatment so people like her dont have to travel abroad.

We are a modern country with an advanced healthcare system and so many more people going for IVF. Its just prohibitive in its cost as it stands.

Cancelled flights

Emma was in Prague for her first round of treatment during the week. She said the service was great but the overall experience was stressful.

Ive just had my first trip to Prague to a great clinic there, but the added layer of having to book flights, presuming they werent going to be cancelled, then constantly watching the government advice on international travel and Covid isolation periods was a huge source of stress.

Im back now but I have to take two weeks off work to isolate and thats a tricky thing to do.

Emma is concerned that if increased restrictions are introduced early next year, she may be unable to travel to Prague.

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This is what really worries me. It will be another few months before I go back for the next round of treatment and Im really worried that international travel will be banned, we might be in a strict lockdown or the same thing could be happening in Prague.

What if I have appointments and flights booked and I have to cancel? Its a hugely stressful time as you have to follow strict hormone protocols for this kind of treatment, so Covid is a very unwelcome complication.

Publicly-funded IVF in Ireland

Health Minister Stephen Donnelly spoke about plans for a publicly-funded IVF system in Ireland, as set out in the Programme for Government, in the Dil earlier this month.

This model of care will ensure that infertility issues will be addressed through the public health system at the lowest level of clinical intervention necessary, Donnelly said.

He noted that the plan will comprise three stages, starting in primary care (GPs) and extending into secondary care (regional fertility hubs) and then, where necessary, tertiary care (IVF and other advanced assisted human reproduction (AHR) treatments).

Structured referral pathways will be put in place and patients will be referred onwards for further investigations or treatment as required and as clinically appropriate. It is intended that, in line with available resources, this model of care for infertility will be rolled out on a phased basis over the course of the coming years, Donnelly said.

The implementation of the model of care will help to ensure the provision of safe, effective and accessible infertility services at all levels of the public health system as part of the full range of services available in obstetrics and gynaecology, he added.

Browne believes it will take quite a few years for publicly funded fertility treatment to be available in Ireland making it too late for many people.

She said a part-funded model is more likely where investigations and blood tests may be paid for by the State.

I personally cannot see the model in the UK, or in other countries where they will fund for two or three IVF cycles, here. I dont know, maybe way down the line.

Guidelines in the UK recommend that IVF is offered on the NHS to women under the age of 40 who have not conceived after two years of regular unprotected sex, or who have had 12 cycles of artificial insemination. These women should be offered three full cycles of IVF, the guidelines say.

In women aged 4042 years, the guidelines say they should be offered one full cycle of IVF, once certain criteria is met.

Advice and support can be found on the NISIGs website.

*Emmas name has been changed to protect her identity.

With reporting by Michelle Hennessy

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'It's a huge source of stress': Women going abroad for IVF hit out at mixed messages over travel restrictions - TheJournal.ie