London, Feb. 1, 2021 // As human beings, each and every one of us is unique yet so many of us rely on universal methods to thrive in our lives and businesses, and feel disheartened when things dont go as wed hoped.

Human Design allows us to understand ourselves on a deep level and shines a light on the simple and bespoke strategies we can use to embrace our magical uniqueness and flourish at work and at home.

According to Bloom Communications, finding expert guidance and support on your journey of self-discovery and transformation is of the utmost importance take a look at our top Human Design coaches leading the way.

Danielle Eyman (@hdbydanielle)

California-based Danielle Eyman launched her business after living according to her design for 3 years a process that saw her wean herself off antidepressants, narcissistic men and friendships, leave a toxic job as a Registered Nurse and repair her relationship with her children.

She said: Ive seen the power of Human Design at work in my own life and its a privilege to see so many of my clients experience these huge shifts too. At the beginning of our journey together, many of them are at rock bottom often with no idea how they got there and they know they need to do something different if life is ever going to feel successful.

Working and experimenting with Human Design means gaining control of your mind and managing your thoughts and thats exactly what we do together with unbiased support and accountability. I help my clients align to and trust their own authority in just three weeks and I have seen results from business transformations to quitting drinking alcohol and boosting self-confidence it truly is incredible to see what we can achieve when we realign to the truth of who we really are.

Danielle is committed to making Human Design more accessible to all and works with her clients through monthly masterclasses, individual chart readings and 1:1 coaching support for women looking to truly embody and integrate the practice into their lives.

Victoria Jane (@victoriajane.hd)

Victoria Jane is a 6/2 Splenic Projector and non-specific manifestor in Human Design. Her mission is to empower growth-oriented folks to live with less hustle and more flow.

The Human Design coach and educator said: Its possible for you to live the life you desire and fulfill your dreams with ease instead of struggle. The reason that Human Design is so amazing is that it gives you a unique blueprint of how your energy works the best part is when I hear from clients who have experimented with living their design the incredible success, confidence, and fulfillment they experience.

After hitting several rock bottom moments including chronic health issues and burnout, Victoria recognised these signs from the Universe and took the leap to start her own business. Working from her home in Oakland CA, Victoria now runs the Human Design Coaching Certification and works with one-on-one clients to uplevel their career and relationships by following their human design.

Victoria added: In addition to the 1:1 work that which I love, what Im most excited about right now is the HD Coaching Cert - because Ive seen Human Design allow coaches to get their clients better results...You literally have a roadmap to how someones designed, so you can give more relevant and personalized guidance to your clients. Plus the community we have, where we are always discussing and going deep on human design topics is the best!

Kyla Derkach (@hathaastro)

Women feeling lost, stuck and hoping to discover their purpose and direction in love, life and business will find their perfect match in Palma De Mallorca-based Kyla Derkach. With a strong background in astrology and certified through the AFA, this Human Design Coach, Modern Astrologer and NLP Practitioner in training has a deep understanding of the patterns and unconscious programming of her clients.

Kyla said: I love working with bold, entrepreneurial, self-aware women who are committed to transforming anything holding them back from living their highest vibe life and making an impact on the world with their unique gifts. Keeping it real with my clients is important and my goal is to take the eye roll out of this stuff.

Kyla works with her clients through a range of consultations and programs across Astrology and Human Design, as well as her online course, Aphrodite Rising, which brings women into deeper alignment with their feminine nature. In 2021, she is launching a group coaching program and mentorship opportunities to help other women learn more about these modalities and how to incorporate them into their own businesses.

Kyla added: Ive been on a real healing journey throughout my life, which saw me pack up my party-filled, glamorous corporate life in Vancouver and set myself up on a majestic little island in the Mediterranean.

I tried many different things to stop getting in my own way you name it, Ive tried it! but it was only when I started integrating my knowledge of Astrology and discovered Human Design that things really started to shift. My mission now is to inspire others to beat self-sabotage, discover who they really are, and create a life and business they love too.

Taylor Eaton (@tayloreatoncoaching)

Washington-based Money Mindset and Human Design Expert, Taylor Eaton, is on a one-woman mission to heal societys relationship with money.

She explains: I dream of seeing our entire society shift away from the toxic patterns we currently have around money and showing people how they can harness the power of abundance for good. I want to create a new paradigm around this energy and help others to approach money in a way that empowers them.

Taylor offers private Human Design readings as well as programs and trainings that help individuals identify their unique blueprint for financial abundance, create aligned strategies for success, and shift their mindset to set them up for effortless income and impact.

Taylor adds: Learning how we are each uniquely designed to make money allows us to welcome more money into our lives with ease and heal blocks that keep money from flowing.

Ive helped countless clients scale their income on their terms and seeing them achieve this never gets old! I love blowing the old ways of doing business and money out of the water and helping people to learn to trust themselves and their own inner guidance.

Corinne Winters (@serveyourmuse)

Creative Living Mentor, Corinne Winters, uses a combination of Human Design, inner work and everyday tools to help creatives own who they are and release the pressure to conform.

Corinne said: Theres nothing more rewarding than helping clients embrace all parts of themselves, especially the things they once saw as quirky or unacceptable, and seeing how the full expression of who they are contributes to their work in the world. Thats why I advocate for Creative Living over self improvement, which implies that we have to change who we are to be good enough. My work is all about reconnecting people with the latent qualities within them originality, depth, courage, authenticity and resilience and helping them live from the inside out.

As a multi-hyphenate creative, Corinne has also spent two decades honing her craft as an internationally acclaimed opera singer, and now uses her expertise and love of teaching to help other curious and introspective people from artists and creatives to parents and entrepreneurs to navigate the same blocks that shes encountered in her journey so far.

People looking to let go of perfectionism, imposter syndrome or self-sabotage can work with Corinne through a variety of 1:1 sessions, interactive group workshops, made-to-order products tailored to their Human Design chart as well as a range of free resources.

Kendra Woods (@SoulfulSuccessByDesign)

Kendra Woods is a Human Design Business Alignment Coach on a mission to help ambitious, heart-centered, high-achieving women in business create success on their terms.

Kendra said: I spent over a decade in the corporate world and completely burned myself out so much so that I began to suffer from anxiety, bouts of depression and several physical health issues. When I finally woke up to the fact that something needed to change, I realized that my truth was that I wanted to life my life on my terms and for me and there was no other way to do that than to start my own business and create my own reality in a way that felt good for me.

The Alabama-based coach works with her clients through a range of services including high-level private coaching, courses, Human Design readings, Business Alignment Blueprints and masterclasses, all designed to help women in business to create success on their terms and in a way that is in alignment for them, creating more ease and flow. She is also the co-author of bestselling book, Girl Get Up and Win.

She added: Its such a blessing to be able to witness the beautiful transformations that my clients experience when we work together. I absolutely love what I do and Im passionate about helping others overcome confusion, self-doubt, low confidence and feeling defeated so that they can create lives that truly light them up.

Tiffani Purdy (@newparadigmbizbestie)

Florida-based Marketing Strategist and Human Design Teacher, Tiffani Purdy, helps coaches, consultants and service-providers to escape the burnout cycle and build businesses that fit in with their ideal life.

Tiffani said: Im all about helping entrepreneurs to get seen and sell their products and services with ease. When we finally drop the comparison and hustle culture and learn how to do things our way according to our Human Design, we can create businesses where we can freely express ourselves, have a lot of fun and make even more money.

Its my dream to see a world where more people have control over their lives and their income. I want Human Design With Tiffani to ultimately contribute to ushering in a new era of business where everyone gets paid well no matter what kind of job theyre doing.

Business owners can work with Tiffani in her signature program, The ENRICH Formula, where theyll learn the basics of Human Design, a therapeutic process to use and apply it in a personal development format, and how to use it to build a business that makes sense for their energetic design.

Cat Skreiner (@cat.skreiner)

Cat Skreiner started her entrepreneurial journey when she was seeking more balance in her life after becoming a new mother. Despite intending to return to her corporate role in digital for a global beauty brand after maternity life, she knew it was time to follow her true purpose in life and has never looked back.

Today, the Perth-based coach is now on a mission to help women in business to truly understand how they best operate in this world and what theyre here to do in their lifetime.

Cat said: I fuse more than 14 years experience in the Digital Marketing industry with Human Design to help my clients catapult their business success and drive massive impact through the integration and embodiment of their unique energetic gifts.

Whether Im working with female entrepreneurs through coaching and mentoring or personal readings, I use a combination of Human Design, Gene Keys and Team Energetics help them to create a business that is more intentional, aligned with their design and allows them to share their greatness with the world in a way that feels easy, fun and abundant.

Alexandra Danieli (@alexandra.danieli)

After years in the corporate and tech industry following leadership that wasnt in alignment with her values and vision, Alexandra Danieli took the leap to pursue her soul purpose supporting people in their spiritual growth and helping them to create the life they desire in their wildest dreams.

Working from her home in California, she now works with her clients through a range of private 1:1 and group coaching programs, as well as through the Ultimate Deconditioning System which she co-founded with her business partner and close friend.

Alexandra said: I work with people who are determined not to settle for a mediocre life theyve decided they want to live in abundance, confidence and have a supportive and harmonious romantic relationship. Theyre ready to finally implement the missing piece of the puzzle.

As we work together, I support them to activate their confidence, step into their authentic self, implement healthy relationship patterns, and call in the money they want to make consistently. This is about getting to know the Self on a deep level and transforming what doesnt work anymore upleveling in all aspects of life.

Leslie Collins (@wholeheartedbeing)

Leslie Collins uses Human Design, astrology and self-reflection to support her clients in digging deep to build an intricate understanding of their problems when navigating their partnerships, families, work, friendships and more.

Leslie commented: Wholehearted Being is here for anyone looking for the empowerment to show up authentically in their lives no matter who you are or what your background is. My work is focused on providing my clients with a safe and impartial support system whilst they develop the knowing, understanding and acceptance of themselves, which then equips them to show up fully in their lives.

Leslie offers counseling and coaching sessions to her clients to work on the major pillars of relating and life: Understanding, Communication, Boundaries, Confidence, Clarity and Mindset.

Leslie added: Prior to our sessions, I research everything I can about my clients Human Design, enneagram, love languages, astrology All of this knowledge helps me to be the best support provider I can be, helping them to understand why they are who they are, as well as how they interact with the people in their lives too.

Nadia Gabrielle (@_nadiagabrielle & @projectorsinvited)

Nadia Gabrielle is a multifaceted entrepreneur working at the intersection of business and wellbeing, merging her background in Design Thinking, Service Design and business building with more than 12 years of experience working in the wellness & self-development space.

Nadia said: All of my work is Human Design-informed. By looking up every single clients chart prior to working with them one-on-one, Im able to understand their energetic blueprint; their needs, strengths and areas for us to zoom in on, which makes our time together even more impactful. I work with all types, though being a Projector myself, Im particularly interested in Human Design Projectors, and offer specific Projector Coaching to integrate the mechanics, beauties and particularities of their aura into daily life and work.

Clients can work with Nadia on a 1:1 basis to build subconscious capacity and confidently embody who they wish to be in their lives and work, or in a group setting to learn proven strategic frameworks to create ease, profitability and longevity in their businesses.

Nadia also teaches regular classes on varied topics such as Human Design and the Subconscious Mind, or the Projector Aura in Business, as well as taking service-based business owners like coaches, consultants, creatives and practitioners through her annual Service Design School curriculum that teaches them to design spell-binding service experiences for their clients.

Nadia concluded: Im so lucky to get to work with so many incredible clients and students from all over the world. As a service-based entrepreneur, I get to build strong relationships with the people I work with, and seeing them have real and lasting results and making big strides in their lives and businesses is my favourite thing.

You can keep up with each of these inspirational coaches curated by Bloom Communications on their journeys by following them on Instagram.

Media DetailsContact: Amy WilliamsEmail: amy@bloomcomms.co

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Meet the Human Design Coaches to watch in 2021 - GlobeNewswire

Getting old is a complex matter. Research has shown that gut microbes are one of the factors that can influence several aspects of human life, including aging. Elucidating how a specific microbial species contributes to longevity is quite challenging given the complexity and heterogeneity of the human gut environment.

To explore the influence of bacterial products on the aging process, researchers at Baylor College of Medicine and Rice University developed a method that uses light to directly control specific gene expression and metabolite production from bacteria residing in the gut of the laboratory worm Caenorhabditis elegans.

We used optogenetics, a method that combines light and genetically engineered light-sensitive proteins to regulate molecular events in a targeted manner in living cells or organisms, said co-corresponding author Dr. Meng Wang, Robert C. Fyfe Endowed Chair on Aging and professor of molecular and human genetics and the Huffington Center on Aging at Baylor.

In the current work, the team engineered E. coli bacteria to produce the pro-longevity compound colanic acid in response to green light and switch off its production in red light. They discovered that shining the green light on the transparent worms carrying the modified E. coli induced the bacteria to produce colanic acid, which protected the worms gut cells against stress-induced mitochondrial fragmentation. Mitochondria have been increasingly recognized as important players in the aging process.

When exposed to green light, worms carrying this E. coli strain also lived longer. The stronger the light, the longer the lifespan, said Wang, an investigator at Howard Hughes Medical Institute and member of Baylors Dan L Duncan Comprehensive Cancer Center. Optogenetics offers a direct way to manipulate gut bacterial metabolism in a temporally, quantitatively and spatially controlled manner and enhance host fitness.

For instance, this work suggests that we could engineer gut bacteria to secrete more colanic acid to combat age-related health issues, said co-corresponding author Dr. Jeffrey Tabor, associate professor of bioengineering and biosciences at Rice University. Researchers also can use this optogenetic method to unravel other mechanisms by which microbial metabolism drives host physiological changes and influences health and disease.

Read the complete report in the journal eLife.

Other contributors to this work include first author Lucas A. Hartsough, Mooncheol Park, Matthew V. Kotlajich, John Tyler Lazar, Bing Han, Chih-Chun J. Lin, Elena Musteata and Lauren Gambill. The authors are affiliated with one of more of the following institutions: Baylor College of Medicine, Rice University and Howard Hughes Medical Institute.

Funding for this project was provided by Human Health Services and National Institutes of Health grants (1R21NS099870-01, DP1DK113644 and R01AT009050), National Aeronautics and Space Administration (grant NSTRF NNX11AN39H), the John S. Dunn Foundation and the Welch Foundation.

By Ana Mara Rodrguez, Ph.D.

The rest is here:
Light-activated genes illuminate the role of gut microbes in longevity - Baylor College of Medicine News

The Longevity and Anti-senescence Therapy market is expected to grow from USD X.X million in 2020 to USD X.X million by 2026, at a CAGR of X.X% during the forecast period. The global Longevity and Anti-senescence Therapy market report is a comprehensive research that focuses on the overall consumption structure, development trends, sales models and sales of top countries in the global Longevity and Anti-senescence Therapy market. The report focuses on well-known providers in the global Longevity and Anti-senescence Therapy industry, market segments, competition, and the macro environment.

Under COVID-19 Outbreak, how the Longevity and Anti-senescence Therapy Industry will develop is also analyzed in detail in Chapter 1.7 of the report., In Chapter 2.4, we analyzed industry trends in the context of COVID-19., In Chapter 3.5, we analyzed the impact of COVID-19 on the product industry chain based on the upstream and downstream markets., In Chapters 6 to 10 of the report, we analyze the impact of COVID-19 on various regions and major countries., In chapter 13.5, the impact of COVID-19 on the future development of the industry is pointed out.

A holistic study of the market is made by considering a variety of factors, from demographics conditions and business cycles in a particular country to market-specific microeconomic impacts. The study found the shift in market paradigms in terms of regional competitive advantage and the competitive landscape of major players.

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Key players in the global Longevity and Anti-senescence Therapy market covered in Chapter 4:, Acorda Therapeutics, Unity Biotechnology, Antoxerene, Celgene, Cohbar, Senex Biotechnology, Human Longevity Inc., T.A. Sciences, Agex Therapeutics, Recursion Pharmaceuticals, Calico Life Sciences, Spotlight Bioscience, Powervision Inc., Sierra Sciences Llc, Restorbio, Insilico Medicine, Oisin Biotechnology, Senolytic Therapeutics, Proteostasis Therapeutics Inc., Prana Biotechnology Ltd., Cleara Biotech

In Chapter 11 and 13.3, on the basis of types, the Longevity and Anti-senescence Therapy market from 2015 to 2026 is primarily split into:, Senolytic Drug Therapy, Gene Therapy, Immunotherapy, Others

In Chapter 12 and 13.4, on the basis of applications, the Longevity and Anti-senescence Therapy market from 2015 to 2026 covers:, Longevity, Senescence Inhibition, Cardiovascular Diseases, Neural Degenerative Diseases, Ophthalmology Disorders, Cancer

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Geographically, the detailed analysis of consumption, revenue, market share and growth rate, historic and forecast (2015-2026) of the following regions are covered in Chapter 5, 6, 7, 8, 9, 10, 13:, North America (Covered in Chapter 6 and 13), United States, Canada, Mexico, Europe (Covered in Chapter 7 and 13), Germany, UK, France, Italy, Spain, Russia, Others, Asia-Pacific (Covered in Chapter 8 and 13), China, Japan, South Korea, Australia, India, Southeast Asia, Others, Middle East and Africa (Covered in Chapter 9 and 13), Saudi Arabia, UAE, Egypt, Nigeria, South Africa, Others, South America (Covered in Chapter 10 and 13), Brazil, Argentina, Columbia, Chile, Others, Regional scope can be customized

Years considered for this report:, Historical Years: 2015-2019, Base Year: 2019, Estimated Year: 2020, Forecast Period: 2020-2026

Some Point of Table of Content:

Chapter One: Report Overview

Chapter Two: Global Market Growth Trends

Chapter Three: Value Chain of Longevity and Anti-senescence Therapy Market

Chapter Four: Players Profiles

Chapter Five: Global Longevity and Anti-senescence Therapy Market Analysis by Regions

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Chapter Six: North America Longevity and Anti-senescence Therapy Market Analysis by Countries

Chapter Seven: Europe Longevity and Anti-senescence Therapy Market Analysis by Countries

Chapter Eight: Asia-Pacific Longevity and Anti-senescence Therapy Market Analysis by Countries

Chapter Nine: Middle East and Africa Longevity and Anti-senescence Therapy Market Analysis by Countries

Chapter Ten: South America Longevity and Anti-senescence Therapy Market Analysis by Countries

Chapter Eleven: Global Longevity and Anti-senescence Therapy Market Segment by Types

Chapter Twelve: Global Longevity and Anti-senescence Therapy Market Segment by Applications 12.1 Global Longevity and Anti-senescence Therapy Sales, Revenue and Market Share by Applications (2015-2020) 12.1.1 Global Longevity and Anti-senescence Therapy Sales and Market Share by Applications (2015-2020) 12.1.2 Global Longevity and Anti-senescence Therapy Revenue and Market Share by Applications (2015-2020) 12.2 Longevity Sales, Revenue and Growth Rate (2015-2020) 12.3 Senescence Inhibition Sales, Revenue and Growth Rate (2015-2020) 12.4 Cardiovascular Diseases Sales, Revenue and Growth Rate (2015-2020) 12.5 Neural Degenerative Diseases Sales, Revenue and Growth Rate (2015-2020) 12.6 Ophthalmology Disorders Sales, Revenue and Growth Rate (2015-2020) 12.7 Cancer Sales, Revenue and Growth Rate (2015-2020)

Chapter Thirteen: Longevity and Anti-senescence Therapy Market Forecast by Regions (2020-2026) continue

List of tablesList of Tables and Figures Table Global Longevity and Anti-senescence Therapy Market Size Growth Rate by Type (2020-2026) Figure Global Longevity and Anti-senescence Therapy Market Share by Type in 2019 & 2026 Figure Senolytic Drug Therapy Features Figure Gene Therapy Features Figure Immunotherapy Features Figure Others Features Table Global Longevity and Anti-senescence Therapy Market Size Growth by Application (2020-2026) Figure Global Longevity and Anti-senescence Therapy Market Share by Application in 2019 & 2026 Figure Longevity Description Figure Senescence Inhibition Description Figure Cardiovascular Diseases Description Figure Neural Degenerative Diseases Description Figure Ophthalmology Disorders Description Figure Cancer Description Figure Global COVID-19 Status Overview Table Influence of COVID-19 Outbreak on Longevity and Anti-senescence Therapy Industry Development Table SWOT Analysis Figure Porters Five Forces Analysis Figure Global Longevity and Anti-senescence Therapy Market Size and Growth Rate 2015-2026 Table Industry News Table Industry Policies Figure Value Chain Status of Longevity and Anti-senescence Therapy Figure Production Process of Longevity and Anti-senescence Therapy Figure Manufacturing Cost Structure of Longevity and Anti-senescence Therapy Figure Major Company Analysis (by Business Distribution Base, by Product Type) Table Downstream Major Customer Analysis (by Region) Table Acorda Therapeutics Profile Table Acorda Therapeutics Production, Value, Price, Gross Margin 2015-2020 Table Unity Biotechnology Profile Table Unity Biotechnology Production, Value, Price, Gross Margin 2015-2020 Table Antoxerene Profile Table Antoxerene Production, Value, Price, Gross Margin 2015-2020 Table Celgene Profile Table Celgene Production, Value, Price, Gross Margin 2015-2020 Table Cohbar Profile Table Cohbar Production, Value, Price, Gross Margin 2015-2020 Table Senex Biotechnology Profile Table Senex Biotechnology Production, Value, Price, Gross Margin 2015-2020 Table Human Longevity Inc. Profile Table Human Longevity Inc. Production, Value, Price, Gross Margin 2015-2020 Table T.A. Sciences Profile Table T.A. Sciences Production, Value, Price, Gross Margin 2015-2020 Table Agex Therapeutics Profile Table Agex Therapeutics Production, Value, Price, Gross Margin 2015-2020 Table Recursion Pharmaceuticals Profile Table Recursion Pharmaceuticals Production, Value, Price, Gross Margin 2015-2020 Table Calico Life Sciences Profile Table Calico Life Sciences Production, Value, Price, Gross Margin 2015-2020 Table Spotlight Bioscience Profile Table Spotlight Bioscience Production, Value, Price, Gross Margin 2015-2020 Table Powervision Inc. Profile Table Powervision Inc. Production, Value, Price, Gross Margin 2015-2020 Table Sierra Sciences Llc Profile Table Sierra Sciences Llc Production, Value, Price, Gross Margin 2015-2020 Table Restorbio Profile Table Restorbio Production, Value, Price, Gross Margin 2015-2020 Table Insilico Medicine Profile Table Insilico Medicine Production, Value, Price, Gross Margin 2015-2020 Table Oisin Biotechnology Profile Table Oisin Biotechnology Production, Value, Price, Gross Margin 2015-2020 Table Senolytic Therapeutics Profile Table Senolytic Therapeutics Production, Value, Price, Gross Margin 2015-2020 Table Proteostasis Therapeutics Inc. Profile Table Proteostasis Therapeutics Inc. Production, Value, Price, Gross Margin 2015-2020 Table Prana Biotechnology Ltd. Profile Table Prana Biotechnology Ltd. Production, Value, Price, Gross Margin 2015-2020 Table Cleara Biotech Profile Table Cleara Biotech Production, Value, Price, Gross Margin 2015-2020 Figure Global Longevity and Anti-senescence Therapy Sales and Growth Rate (2015-2020) Figure Global Longevity and Anti-senescence Therapy Revenue ($) and Growth (2015-2020) Table Global Longevity and Anti-senescence Therapy Sales by Regions (2015-2020) Table Global Longevity and Anti-senescence Therapy Sales Market Share by Regions (2015-2020) Table Global Longevity and Anti-senescence Therapy Revenue ($) by Regions (2015-2020) Table Global Longevity and Anti-senescence Therapy Revenue Market Share by Regions (2015-2020) Table Global Longevity and Anti-senescence Therapy Revenue Market Share by Regions in 2015 Table Global Longevity and Anti-senescence Therapy Revenue Market Share by Regions in 2019 Figure North America Longevity and Anti-senescence Therapy Sales and Growth Rate (2015-2020) Figure Europe Longevity and Anti-senescence Therapy Sales and Growth Rate (2015-2020) Figure Asia-Pacific Longevity and Anti-senescence Therapy Sales and Growth Rate (2015-2020) Figure Middle East and Africa Longevity and Anti-senescence Therapy Sales and Growth Rate (2015-2020) Figure South America Longevity and Anti-senescence Therapy Sales and Growth Rate (2015-2020) Figure North America Longevity and Anti-senescence Therapy Revenue ($) and Growth (2015-2020) Table North America Longevity and Anti-senescence Therapy Sales by Countries (2015-2020) Table North America Longevity and Anti-senescence Therapy Sales Market Share by Countries (2015-2020) Figure North America Longevity and Anti-senescence Therapy Sales Market Share by Countries in 2015 Figure North America Longevity and Anti-senescence Therapy Sales Market Share by Countries in 2019 Table North America Longevity and Anti-senescence Therapy Revenue ($) by Countries (2015-2020) Table North America Longevity and Anti-senescence Therapy Revenue Market Share by Countries (2015-2020) Figure North America Longevity and Anti-senescence Therapy Revenue Market Share by Countries in 2015 Figure North America Longevity and Anti-senescence Therapy Revenue Market Share by Countries in 2019 Figure United States Longevity and Anti-senescence Therapy Sales and Growth Rate (2015-2020) Figure Canada Longevity and Anti-senescence Therapy Sales and Growth Rate (2015-2020) Figure Mexico Longevity and Anti-senescence Therapy Sales and Growth (2015-2020) Figure Europe Longevity and Anti-senescence Therapy Revenue ($) Growth (2015-2020) Table Europe Longevity and Anti-senescence Therapy Sales by Countries (2015-2020) Table Europe Longevity and Anti-senescence Therapy Sales Market Share by Countries (2015-2020) Figure Europe Longevity and Anti-senescence Therapy Sales Market Share by Countries in 2015 Figure Europe Longevity and Anti-senescence Therapy Sales Market Share by Countries in 2019 Table Europe Longevity and Anti-senescence Therapy Revenue ($) by Countries (2015-2020) Table Europe Longevity and Anti-senescence Therapy Revenue Market Share by Countries (2015-2020) Figure Europe Longevity and Anti-senescence Therapy Revenue Market Share by Countries in 2015 Figure Europe Longevity and Anti-senescence Therapy Revenue Market Share by Countries in 2019 Figure Germany Longevity and Anti-senescence Therapy Sales and Growth Rate (2015-2020) Figure UK Longevity and Anti-senescence Therapy Sales and Growth Rate (2015-2020) Figure France Longevity and Anti-senescence Therapy Sales and Growth Rate (2015-2020) Figure Italy Longevity and Anti-senescence Therapy Sales and Growth Rate (2015-2020) Figure Spain Longevity and Anti-senescence Therapy Sales and Growth Rate (2015-2020) Figure Russia Longevity and Anti-senescence Therapy Sales and Growth Rate (2015-2020) Figure Asia-Pacific Longevity and Anti-senescence Therapy Revenue ($) and Growth (2015-2020) Table Asia-Pacific Longevity and Anti-senescence Therapy Sales by Countries (2015-2020) Table Asia-Pacific Longevity and Anti-senescence Therapy Sales Market Share by Countries (2015-2020) Figure Asia-Pacific Longevity and Anti-senescence Therapy Sales Market Share by Countries in 2015 Figure Asia-Pacific Longevity and Anti-senescence Therapy Sales Market Share by Countries in 2019 Table Asia-Pacific Longevity and Anti-senescence Therapy Revenue ($) by Countries (2015-2020) Table Asia-Pacific Longevity and Anti-senescence Therapy Revenue Market Share by Countries (2015-2020) Figure Asia-Pacific Longevity and Anti-senescence Therapy Revenue Market Share by Countries in 2015 Figure Asia-Pacific Longevity and Anti-senescence Therapy Revenue Market Share by Countries in 2019 Figure China Longevity and Anti-senescence Therapy Sales and Growth Rate (2015-2020) Figure Japan Longevity and Anti-senescence Therapy Sales and Growth Rate (2015-2020) Figure South Korea Longevity and Anti-senescence Therapy Sales and Growth Rate (2015-2020) Figure Australia Longevity and Anti-senescence Therapy Sales and Growth Rate (2015-2020) Figure India Longevity and Anti-senescence Therapy Sales and Growth Rate (2015-2020) Figure Southeast Asia Longevity and Anti-senescence Therapy Sales and Growth Rate (2015-2020) Figure Middle East and Africa Longevity and Anti-senescence Therapy Revenue ($) and Growth (2015-2020) continue

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NOTE: Our report does take into account the impact of coronavirus pandemic and dedicates qualitative as well as quantitative sections of information within the report that emphasizes the impact of COVID-19.

As this pandemic is ongoing and leading to dynamic shifts in stocks and businesses worldwide, we take into account the current condition and forecast the market data taking into consideration the micro and macroeconomic factors that will be affected by the pandemic.

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Longevity and Anti-senescence Therapy Market 2020 Study Report by Industry Types, Growth, Share, Size, Key Manufacturers, Revenue, Trends, COVID-19...

The pandemic has forced many people to rethink how they lead their lives. Research by Cambridge Weight Plan has found that more than two thirds of the public (68 percent) will be switching up their diet in 2021. Knowing how to maximise the health benefits of your dietary decisions can be challenging, however.

As Gilbert explains, type-2 diabetes is "virtually absent" in those who restrict calories and follow a low-calorie diet such as the 1:1 Diet.

In fact, the 1:1 Diet has been shown to reverse diabetes in those who undertake it, as long it is sufficiently nutritious, Gilbert says.

The Cambridge 1:1 diet is a VLCD (Very low-calorie diet) meal replacement diet in which 415 to 1500 calories are consumed daily through a combination of meal replacement bars, smoothies, shakes and soups.

Extensive evidence points to the benefits of following a low-calorie diet.

One study published in Cell Metabolism journal this month concluded that cutting calorie intake by 15 percent over two years can slow ageing and protect against diseases such as cancer, diabetes, and Alzheimers.

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Vitamin D, otherwise known as the sunshine vitamin, is obtained through direct exposure to sun, although supplements are usually required to top up the vitamin in winter time.

"Vitamin D is intimately involved in immunity, protecting us particularly by helping our T cell immune response," Gilbert explains.

Studies have shown that vitamin D levels in the body are inversely related to the risk of death.

According to a large review study, low vitamin D levels have been linked to all-cause, cardiovascular, cancer and infectious-related mortality.

Gilbert explains: Berries have a number of health advantages and have been shown to improve heart health, reduce incidence and risk of cancer and diabetes, and to reduce blood pressure.

According to Gilbert, adding berries to a sugary meal can slow and reduce the appearance of blood sugar (glucose) in your blood.

"In turn this assists blood flow by helping your blood vessels dilate but also reduce the 'stickiness' of your blood, preventing inflammation and build-up of cholesterol," he says.

Cholesterol is a waxy substance that raises your risk of heart disease.

Test-tube and human studies suggest that they berries protect your cells from high blood sugar levels, help increase insulin sensitivity, and reduce blood sugar and insulin response to high-carb meals.

"Those who drink green tea seem to be protected from the dreaded all-cause mortality (death from any cause), even when researchers control for other behaviours," explains Gilbert.

This should raise few eyebrows. As Gilbert points out, green tea consumption protects DNA, helps with blood sugar control and may help prevent diabetes, decreases blood pressure and reduces arterial plaque.

According to a review of seven studies with a total of 286,701 individuals, tea drinkers had an 18 percent lower risk of diabetes.

See more here:
How to live longer: Four simple dietary decisions that are proven to boost longevity - Express

Hello! Im Mark Olsen. Welcome to another edition of your regular field guide to a world of Only Good Movies.

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This is our first newsletter of 2021, and it has already been quite a year.

The events of this past week surpass any thoughts on movies at the moment. I feel I have likely said this before, but there is no one better at sorting through the cultural confusion of a moment like Wednesday than Times TV critic Lorraine Ali. As she wrote, Wednesdays violent attack cannot be seen as yet another preparatory stress test for democracy. It was the real thing. We, as a nation, are not immune to the crises in which we are so often intervening overseas, parachuting in to save the day and frequently mucking things up further by trying we should never again assume well be saved from the fate of nations that have fallen victim to tyrants by mere privilege alone.

Mary McNamara wrote about the weeks events as well. Ignorance, misunderstanding, claims of party divisions are no longer applicable the division is not about big government versus small, its about democratic government versus dictatorship. This is not about the grievances, real and imagined, of small-town America or the danger of elitist bubbles, real and imagined, of coastal cities. This is about people who believe America wont be great again until representative democracy is not just suppressed through racist voter restrictions and regional gerrymandering but completely destroyed.

And Carolina Miranda had these sharp thoughts on the Capitol building itself: The Capitol is indeed a symbol of democracy a troubled one, but an evolving one. One whose narratives are not yet fully written. That will be up to us.

There was nevertheless other news as well. Over the holidays, filmmaker Joan Micklin Silver died at age 85. Silver was the groundbreaking director of movies such as Hester Street, Between the Lines, Chilly Scenes of Winter and Crossing Delancey. In 1991, while speaking to an audience at the American Film Institute, she said, Be tenacious. Be strong. Be courageous. What can I say? Keep it up. You have to learn to take rejection. You have to learn to believe in yourself.

The first episode of The Envelope podcast of the new year features my conversation with Kemp Powers, who wrote the screen adaption of his own play One Night in Miami and co-wrote and co-directed the new Pixar animated film Soul. As Powers said of this rather remarkable moment of having two films out at the same time, That wasnt the plan. The world were living in has plans of its own.

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Directed by Kornl Mundrucz from a screenplay by Kata Weber, Pieces of a Woman is an exploration of one woman (Vanessa Kirby) working through the grief of losing a baby in childbirth. The movie starts with an extended single-take sequence of a home birth gone wrong depicted with startling momentum and gets more intense. Kirby won the prize for best actress when the film premiered at the Venice Film Festival, and the cast also includes Ellen Burstyn, Shia LaBeouf, Molly Parker and Sarah Snook. The film is streaming on Netflix.

If Burstyn were to be nominated for an Oscar, at 88 years old, she would become the oldest actor ever nominated by eight days. I really want that, I must say, she told Gary Goldstein for The Times. I think thats a badge of something. Of longevity, certainly!

Reviewing the film for The Times, Justin Chang wrote about the supporting characters orbiting Kirby. Arrestingly showy though they can be, these performances never threaten to eclipse or overwhelm Kirbys concentration. While this remarkable actor can unleash hell with the best of them, her most eloquent gestures here are her quietest, whether shes staring distractedly into the middle distance or deflecting her moms affectionate gesture, as if it were a slap in the face. Kirbys authority is commanding, even unassailable: At times Martha seems at odds with not only her loved ones but with the very movie shes in, firmly steering it away from the courtroom drama, or even the portrait of a relationships bitter end, that it seems on the verge of becoming. She keeps you off balance right through the dreamlike close, a final scene brave, misguided or both that suggests nothing is ever truly final.

In a review for rogerebert.com, Monica Castillo wrote, Kirby has to navigate her character through every parents waking nightmare, which she does impressively. As Martha, Kirby shifts from catatonic to chaotic, becoming just as destructive as her partner without feeling like a clich. Shes angry at Sean, her co-workers, her family especially her mom, Elizabeth (Ellen Burstyn), who talks about her loss as if it were a personal failure and chides Martha for not actively pressing charges against the midwife. Its a tension that leads to the best scene of the movie, a showdown between mother and daughter, both grieving and each with entirely different ideas on how to move forward. Its a moment so electric, it makes the marital drama feel like window dressing.

For Vanity Fair, Katie Rich wrote, Pieces of a Woman tends to tell instead of show, with Elizabeth admitting to Sean that she never liked him before weve really gotten a grasp on their relationship, or Sean escalating a fight into name-calling that feels out of character. It makes the excruciating childbirth sequence stand out all the more, as Benjamin Loebs camera swoops past Parkers worried eyes, LaBeoufs tightly coiled body language, or Kirbys throat letting out the guttural moans of a woman who thinks the labor is going to be the most painful part. That long, beautiful, heartbreaking scene finds bracing cinematic language for a process that is so often euphemized until the tragic conclusion, it is a remarkably realistic childbirth for a narrative film, in all its gross wonder. It is a relief when the scene ends, but also a bit of a shame, watching that lightning bolt recede into a more modest flicker.

Vanessa Kirby as Martha in Pieces of a Woman.

(Benjamin Loeb / Netflix)

Directed by Phyllida Lloyd from a screenplay by Malcolm Campbell and Clare Dunne, Herself tells the story of a woman (Dunne) in Dublin trying to rebuild her life for her and her daughters after leaving an abusive husband. Having premiered at last years Sundance Film Festival, it is streaming on Amazon Prime Video.

For The Times, Robert Abele wrote, Lloyd, directing her first film since telling a most opposite tale in The Iron Lady that of a powerful woman (Meryl Streeps Oscar-winning Margaret Thatcher) on the wane is very much in sync with the plucky empowerment saga Dunne wants to tell and embody. (Its collaborative synchronicity born from the pairs work together in theater.) Yet that silver-lining nature is also what keeps Herself from entirely distinguishing itself, too often leaving an admittedly powerful story about female fortitude to rely on schematics and clichs instead of the accumulated impact of its many well-played human details.

For the Washington Post, Ann Hornaday wrote, A colorful cast of friends and friends-of-friends helps to make Herself not just a celebration of one womans determination, but of community a portrait that feels like a lets-put-on-a-show fantasy grounded in the social principles of Ken Loach. Its a not always a convincing combination but, in Dunnes capable hands, its a fetching and absorbing one.

Clare Dunne, from left, Ruby Rose OHara and Molly McCann in the movie Herself.

(Pat Redmond / Amazon Studios)

Directed by Bryan Fogel, The Dissident is a documentary on Jamal Khashoggi, the Saudi Arabian journalist who was murdered in Turkey in 2018. Featuring interviews with Khashoggis fiance, Hatice Cengiz, and others, the film is something of a real-life international espionage thriller. The movie is available on video on demand.

Stuart Miller wrote about the movie for The Times, talking to Fogel about the path that took him from his Academy Award-winning debut documentary Icarus to this new film. The filmmaker said, Winning the Oscar, I felt an obligation to make more stories that would have an impact on society.

In a review for The Times, Robert Abele wrote, Some of Fogels techniques speak more to the slick state of advocacy docs these days than to what would most effectively tell the story, from the overworked score and editing to some regrettable computer animation that briefly feels like one has entered a video game simulation. Tyranny and its effects are no video game, but The Dissident overall retains the impact of its alarming narrative, never more so than when were reminded of how much support President Trump gave MBS despite his own intelligence agencies conclusion that the crown prince ordered the hit on Khashoggi. One can only hope the future wont see a preference for arms deals over principles of human decency.

Reviewing the movie for the New York Times, Devika Girish wrote, All of this material is so chilling and effective on its own that the movies emphatic music and computer-generated graphics which include a Twitter battle pictured as a showdown between 3-D flies and bees can feel like overkill. But these flourishes serve the films ultimate objective: to impress acutely upon us the injustice of a world where money and geopolitics supersede human rights.

Saudi Crown Prince Mohammed bin Salman, left, and journalist Jamal Khashoggi in the documentary The Dissident.

(Briarcliff Entertainment)

See the original post here:
Indie Focus: Grief and resilience in 'Pieces of a Woman' - Los Angeles Times

The 2021 predictions to back are the ones grounded in genuine

human understanding

The beginning of every year always sees a wave of inspirational trends look ahead pieces. The full-on bombardment of thinking often makes it hard to tell which are grounded in fact, which are just blue-sky thinking and who really is on the money.

There is an even greater onslaught of this will happen thinking out there than normal, partly since so many of last years forecasts went out of the window at the start of March. Also, arguably, no year in history has been more eagerly anticipated than 2021, with consumers battling conflicting emotions:

The hope that it will be better than 2020 and a collective determination to make it so

A nagging concern that it will be just as bad as last year

This makes it only natural for marketers to look even more closely than usual at the body of published trends work: which trends to believe and, more crucially, which to pin their companys 2021 on? Of course, it doesnt help when the various POVs are awash with contradictions and vested interests, or when there are so many.

Thats why weve done the hard work for marketers, ploughing our way through 30+ of the 2021 lookaheads in the public domain. Weve added our own expertise, backed by leading edge research, and run the ideas past our gold-standard teams specialising in comms, marketing and digital.

Based on all of that, here is our pick of 10 trends. Five in the consumer space and five in the marketing space to focus on.

5 Consumer trends to focus on

1. A changing relationship with physical spaces, town centres and a heightened focus on the local.

25% of UK urbanites want to move out of the metropolitan areas where they currently live

2. Sustainability: a green (re)awakening the end of more, moving away from big lifestyles, contentment with less, reducing waste.

72% of global consumers said companies behaving sustainably was more important to them because of COVID-19

3. A new fluidity. Weve lost many of the rituals that used to signpost our lives resulting in a sense of collective displacement. We may have replaced them with digital equivalents but over the coming year(s) well see a more proactive emergence of new models and rules.

Microsoft Japans experiment with a four-day workweek earlier this year resulted in a 40% in worker productivity.

4. In 2021, well see the emergence of a newly resilient consumer, taking control of their lives, balancing forward planning with an ability to roll with the punches, and innovating their own solutions.

Studies show that consumers are significantly more likely to try new brands when they go through a major life event.

5. Kindness culture and a return to we as the new-found appreciation of others will manifest itself in a greater focus on community, helpfulness, kindness, support, and empathy.

39% of those living with friends/roommates are concerned about their mental wellbeing.

5 Marketing trends to focus on

1. Organising for agility and flex. With the economy more unpredictable than ever, and with companies having all of last years pivoting stories fresh in their minds, organisations will be trying to be disruption-ready, setting themselves up in such a way that they can rapidly alter course to take account of any new wind direction.

82% said when brands pivoted to offer new, more relevant products or services it increased their desire to do more business with them.

2. Taking customer experience to the max. The rise of DTC will continue. Brands will shift the bar ever higher on service. The emphasis in delivery will shift from last mile to last few feet as organisations realise that product handovers represent something too important to trust to time pressured and disinterested couriers.

62% of marketers agreed that they actively consider the impact of packaging and delivery on customer experience.

3. 2021 will see brand purpose get real as consumers demand brands walk the walk as well as talking the talk with firm brand promises or pledges and acts not mere words.

60% of millennials & Gen Z say they plan on buying more from large businesses that have taken care of their workforces and positively affected society during the pandemic

4. The holy grail of distinctiveness: COVID was such a powerful disruptor that it encouraged convergence of product offerings and marketing message channel choice content, tone, and execution. 2021 will see brands making concerted efforts to refind themselves and re-express their uniqueness though such high-risk strategies are bound to create both winners and losers.

64% of marketers agree that advertising suffered from a lack of distinctiveness during quarantine, and there is a danger that this will persist

5. E-commerce innovation will surge. 2021 will see innovation in what online retail looks and feels like well see shoppable social surge ahead, purchasing via livestreaming take off, and efforts to make the online shopping process look and feel more like being in store, start to bear fruit.

In China, a Tommy Hilfiger livestream event attracted 14 million viewers and sold out of 1,300 hoodies in two minutes

Focus on Human Understanding signals, not noise

With so much noise out there, the brands that thrive in 2021 will be the ones that can correctly pick out the ones that fit a consumer truth and offer real longevity.

Link:
New Year, New Noise: 2021 predictions | UNLIMITED | Open Mic - The Drum

Ready to blast off and join thousands of attendees around the world atTC Sessions: Space 2020 on December 16-17? The event, focused on space technology and dedicated to helping early-stage startups succeed in this exciting yet daunting industry, features panel discussions and interviews with the top leaders, visionaries and makers on the planet.

Want to save $50? Buy your pass before Tuesday, December 15 at 11:59 p.m. (PT) to lock in the Late Registration price before rates increase.

While youll find many of these brilliant experts speaking from the Main Stage, dont miss the focused programming we have lined up for the Breakout Sessions. Thats where youll find our partners sharing their in-depth expertise on a range of topics. Check out these breakouts waiting to drop a galaxys worth of knowledge on you.

(all times in PST)

9:00 10:00 a.m.

Fast Money SMC Space Ventures, AFWERX and Space Force Accelerators

Learn how SMC Space Ventures, AFWERX and Space Force Accelerators work together to connect startups to government organizations and resources in the space industry.

10:00 11:00 a.m.Sponsored bySP8CEVC

Introducing the launch of the Worlds First Space Technology and Human Longevity focused Rolling Fund in partnership with AngelList

Fireside chat with the general partners and team from SP8CEVC covering the verticals of Space Technology and Human Longevity.

11:00 11:30 a.m.

Fast Money Working with the Army to Operationalize Science for Transformational Overmatch

Learn about DEVCOM Army Research Laboratory and the xTech Program of prize competitions that accelerate innovative solutions that can help solve Army challenges.

11:30 12:30 p.m.

Pitch Feedback Session

Join us for a pitch feedback session open to all startups exhibiting at TC Sessions: Space 2020 moderated by TechCrunch staff.

1:00 1:50 p.m.Sponsored byThe Aerospace Corporation

University Showcase Boldly Innovating in Space, for Space (Part One)

Technologies to Go Boldly in Space For the past half century, space exploration and technology has been earth-centric. Weve studied the earth, orbited the earth and sent images of distant places back to earth. In the coming decade, well embark on a new commitment: Were going to space to stay. Were committing to space commerce, space habitation and space exploration in order to not just stay in space, but to extend our human footprint into this solar system. To be successful, we need bold people and new technology to build and deploy the next generation of space capabilities. We need to capture these space opportunities, avoid potential threats and deliver on the promise of a multi-planet human race. This session showcases our partners USC and MIT, as they provide insight into their space programs. They are joined by university partners UCLA, ASU and Caltech, showcasing a range of emerging space technologies. Working with the Aerospace Corporation, these emerging capabilities can be evaluated and integrated into government space-faring missions for communicating, navigating and exploring in space with NASA, NOAA and the Air Force.

9:00 9:30 a.m.

Cislunar Space: Building a Self-Sustaining Lunar Economy

We are standing on the threshold of a post-scarcity human future. Cislunar space, the area between the Earth and the moon, holds the keys to a tremendous wealth of opportunities.

9:30 10:00 a.m.

Fast Money Advancing Space Technology with NASA SBIR

Learn about the Small Business Innovation Research (SBIR) and the Small Business Technology Transfer (STTR) programs powered by NASA.

10:00 10:30 a.m.

Fast Money NAVWAR SBIR/STTR Primer: The SBIR/STTR is a robust program designed to help small businesses address government needs while promoting commercialization. This session is dedicated to providing a primer on the program with tips on getting involved and getting engaged with the Naval Information Warfare Systems Command (NAVWAR).

10:30 11:00 a.m.

Fast Money Introduction to In-Q-Tels investing activities in the commercial space sector: In-Q-Tel is a strategic investment firm that works with the national security community of the United States. For 20 years, In-Q-Tel has served one mission: to deliver the most sophisticated strategic technical knowledge and capabilities to the U.S. government and its allies through its unique investment model. Over the past decade, In-Q-Tel has been one of the most active investors in the commercial space sector, with a broad investment thesis that touches many aspects of the sector. This session will provide an overview of In-Q-Tel as a whole, as well as a discussion of the firms activities in the commercial space sector.

11:00 11:30 a.m.

Fast Money Enabling a dual-use business model with Defense Innovation Unit (DIU)

Learn how you can take a part of DIUs development of on-demand access to space, persistent satellite capabilities and broadband space data transfer

11:30 12:30 p.m.

Starburst x TechCrunch Pitch Me to the Moon: Starburst Aerospace and TechCrunch are teaming up to launch a pitch competition like no other Pitch Me to the Moon. Think Startup Battlefield, but for space. Ten promising early-stage space startups (selected by Starburst) will have an opportunity to present their innovations live to a panel of high-profile judges from across the industry.

1:00 1:50 p.m.Sponsored byThe Aerospace Corporation

University Showcase Boldly Innovating in Space, for Space (Part Two)

Bold Missions For the past half century, space exploration and technology has been earth-centric. Weve studied the earth, orbited the earth and sent images of distant places back to earth. In the coming decade, well embark on a new commitment: Were going to space to stay. Were committing to space commerce, space habitation and space exploration in order to not just stay in space, but to extend our human footprint into this solar system. To be successful, we need bold people and new technology to build and deploy the next generation of space capabilities. We need to capture these space opportunities, avoid potential threats and deliver on the promise of a multi-planet human race. This session showcases our partners USC and MIT, as they provide insight into their space programs. They are joined by university partners UCLA, ASU and Caltech, showcasing a range of emerging space technologies. Working with the Aerospace Corporation, these emerging capabilities can be evaluated and integrated into government space-faring missions for communicating, navigating, and exploring in space with NASA, NOAA and the Air Force.

Whew, talk about a great lineup. You might say its out-of-this-world which raises the question: Can you hear a rimshot in space? Dont forget to peruse the rest of our programming in the event agendaand start planning your schedule now.

Pro Tip: Say goodbye to FOMO. Our virtual platform makes it easy to toggle between the Main Stage and Breakout Sessions. Plus, youll have access to video on demand, so you wont miss a beat (excluding the Expo Ticket).

Remember, late registration savings end on Tuesday, December 15 at11:59 p.m. (PT). We also offer discount passes for groups, students and government, military and nonprofit employees. Buy the pass thats right for you today!

Is your company interested in sponsoring TC Sessions: Space 2020?Click hereto talk with us about available opportunities.

Read the original:
Dont miss these breakout sessions at TC Sessions: Space 2020 - TechCrunch

The coronavirus pandemic has been a tremendous accelerator of the secular trends we predicted back in December 2019. One thing is clear 2020 marks the end of the neoliberal era, exemplified by extreme monetarism and austerity. In advanced economies, the coming decade will be about fiscal dominance and unprecedented policy intervention in the real economy and financial markets, blurring traditional market signals and thereby reinforcing the importance of a robust strategic asset allocation based on established macro economic trends.

Bipolar Sino-US World The divide between the US and China continues to grow. While trade issues seem to have been put on the backburner, there are continued hostilities between the two countries on other fronts. The most notable subject is the coronavirus, as China is being blamed for the pandemic getting out of hand. With Joe Biden in the White House as of January 20, Democrats might tackle the conflict in a more diplomatic manner and give a greater importance to human rights issues, but the overall hawkish strategy should remain unchanged, if not strengthened.

As China ploughs ahead with the aim of restoring the nation to its previous glory, this 21st century cold war over economic, technological, and military supremacy will usher in a new dual world order, with separate economic and financial cycles and technological ecosystems. In this context, the benefits of international diversification are revived after having been significantly undermined by globalisation, giving investors reason to own both US and Chinese assets in their portfolios.

The emergence of a bipolar Sino-US world and the rise of China are of special interest to investors from the Gulf region in a world with declining interest rates and scarce growth, it is more important than ever to have exposure to regions and sectors which can still deliver positive real returns. China, and Asia more generally, is a hub of growth and innovation, with ever-growing and deepening financial markets, and is set to become the largest global economy this decade.

Unorthodox macroeconomic policies With the end of the neoliberal era comes the inevitable end of the policy toolbox dominated by monetary instruments. This policy template, which was in fact designed to solve problems that predated this period of extreme globalisation and financialisation, is dead, and the coronavirus crisis has buried it.There are four major aspects to the new policy landscape. First, with the credit channel out of commission, there will be much more emphasis on fiscal stimulus. As long as developed economies are subject to structural demand deficits and the private sector is unable to sustain growth on its own, the public sector must intervene and spend the savings glut accumulated by households and corporates.

Second, in line with Modern Monetary Theory, central banks will cooperate much more closely with governments to finance (i.e. monetise) the accumulated deficits from these fiscal interventions. Higher debt-to-GDP ratios will be more widely accepted, and the fear of resulting runaway inflation should diminish as deflationary pressures are acknowledged as being much stronger.

Third, stimulus will be implemented more directly. With the merger of the fiscal and monetary arms, central banks could deliver funds directly to households, a tool that could be further supported by the introduction of central bank e-currencies. Policy will thus become more efficient, as it could easily reach all sections of the population, including the most modest households with the highest propensity to consume. In that way, authorities could tackle the income inequality problem as well. We expect that governments will move to reduce inequalities through tools like symmetric taxation (eg. negative taxes for lower-income households, which is a much better option than universal income for all).

Lastly, the unconventional monetary policies that emerged following the 2008 financial crisis will remain, as the main objective of developed-market central banks has by now become financial stability. In fact, it has already been at least a decade since monetary authorities have been practising asset price targeting, that is, supplying liquidity when necessary in order to avoid a negative wealth shock that could in turn derail the real economy. Eventually, these policies should reflate the economy, which is when they would really be put to the test. We are not at that stage yet. We believe, in any case, that the conditions for hyperinflation in developed countries are not even close to being met.

Energy abundance World energy markets and related industries are undergoing profound structural changes. The dependence on fossil fuels, the past decades high prices, climate change, and environmental pollution are only some of the many challenges that have spurred investments and nourished innovation. We believe that we are in the midst of a transition, where new technologies satisfy our growing energy needs without further depleting fossil resources.

The transition to renewables is accelerating thanks to affordability, scalability, and access to infinite resources. Electric cars, air conditioning, and heat pumps mark the next phase of electrification, underpinning the energy carriers future dominance.

Traditional utilities are losing their customer base, as clean energy and new business models are breaking market barriers. From power trading to infrastructure finance, new players are altering the playing field.Meanwhile, the Covid crisis is accelerating the competitive dynamics in the oil business. Private oil companies have to venture to other areas, such as clean energy, to deliver growth and satisfy investors. Yet providing oil will still offer the opportunity to produce valuable cash flows for years to come. Ultimately, this is a shift from resources to technology and from producers to users, bearing broader geopolitical impact and raising the risks of related tremors.

The major transition currently experienced by energy markets is of particular importance to GCC investors. Investors heavily-tilted towards oil companies will need to internalise these structural shifts and turn their attention to renewables and companies that embrace these changes.

Stakeholder economy The benefits of extreme financialisation and globalisation have not been equally distributed across all social and economic groups. Worker compensation has lagged, while corporate profit margins in the developed world have soared, increasing both wealth and income inequality to levels not seen since the 1930s.Meanwhile, climate change and social equality issues have taken centrestage, especially in the eyes of younger generations. These pressure points are pushing the corporate sector to rethink their role in society. Increasingly, corporates are expected to assume ownership of their entire value chain and take active measures to promote sustainability and social responsibility, going beyond the satisfaction of regulatory rules and codes of ethics. This constitutes a major pivot point and a complete rejection of the shareholder-focused model.

Life science disruptions Healthcare areas that are related to digital health, genomics, and extended longevity should see further upside potential over the longer term, given political tailwinds, momentous demographic shifts around the world, the emergence of chronic diseases associated with ageing, and ever-rising medical costs.The Covid-19 pandemic may very well be a watershed moment for the healthcare industry, as it has certainly laid bare the weakness of the entire healthcare value chain. At the same time, the pandemic has given greater impetus to strengthen our resilience for present and future health threats, through greater adoption of digital health technologies and other innovative solutions.

Yves Bonzon is the group chief investment officer at Julius Baer

Continued here:
Five macro trends set to shape the next decade - Gulf Business

The term longevity refers to the number of years you live, and it does have a limit. Our bodies are not designed to live to 120 years, although many of us would like to live that long if we had quality of life for that long, says Gary W. Small, MD, the physician in chief for behavioral health at Hackensack Meridian Health in New Jersey and the former director of the UCLA Longevity Center.

In reality, the normal (and inevitable) processes of oxidative stress and inflammation are thought to contribute to our gradual decline in health as we get older. That doesnt mean were helpless when it comes to our health. In fact, the foods we eat every day play a major role in healthy aging and longevityand a few herbs and spices may be especially helpful.

Inflammation is a natural part of the immune response to fight infection and repair damage from injuries. Excess inflammationis associated with chronic diseases including cardiovascular disease, cancer, diabetes, kidney disease, and non-alcoholic fatty liver disease. We know that heightened inflammation and oxidative stress contribute to age-related diseases, says Dr. Small. If you look at a lot of studies and blood markers of inflammation, we find that age itself is often associated with heightened inflammation. Lifestyle habits, including poor diet, lack of exercise, stress, and a shortage of quality sleep play an important role in accelerating inflammation, he adds.

Thats where plant-based foods can come in. Plants naturally have anti-inflammatory and antioxidant properties, which Dr. Small says may play some role in healthy aging and longevity. This may slow down the process of aging as well as support the immune system and protect against chronic conditions that are more common with age, explains Rachelle Robinette, a clinical herbalist and holistic health practitioner (and host of Well+Goods YouTube show, Plant Based). While we dont know for sure exactly how many antioxidants we need to consume for these effects, studies show that people who consume these kinds of foods live longer and better, says Dr. Small.

That doesnt prove that consuming any one particular food or supplement will have enough of an effect on your inflammation levels to actually have an impact on disease, Dr. Small adds. Were always looking for a quick fix or magic bulletEveryone wants a remedy, but none can even work well if diet and lifestyle are not in place, adds Robinette. In terms of longevity, diet and lifestyle are going to matter more than any herb or supplement. Herbs work wonderfully as medicine, but they really are supplemental.

Caveats aside, some foods really do boast more concentrated levels of disease- and age-fighting compounds than othersand that certainly cant hurt in moderation when you integrate them into your cooking routine. Whats great about spices is it makes your diet more palatable, you want a diet thats nutritious but delicious, says Dr. Small. (Just remember: You should always talk to your doctor before starting any new supplement; some can be toxic at higher doses, especially if youre taking certain prescription medications.)

Ginger is the epitome of food medicine, as Robinette calls it. The compound gingerol in ginger is the source of most of the plants many benefits; it has powerful anti-inflammatory and antioxidant effects and may have anti-cancer properties. (Which, hello longevity!) The Mayo Clinic is currently investigating whether eating 2,000 mg of ginger a day for six weeks can boost the microbiome, aka the collection of bacteria, fungi, and viruses that make up a large part of the human body. That would be a big deal, Robinette explains, since your microbiome affects your overall health, including your brain, mood, and immune system.

Robinette recommends having ginger a few times a week as a fresh extract, grated into food, added to stir-fries, or sliced in a hot cup of tea. You can also try Robinettes recipe for ginger shotswhich may be especially helpful during cold and flu season. I do several shots per day in winter, she says.

Heres the step-by-step for making Robeinettes ginger shot to reap the benefits of the plant:

You cant talk about herbs for longevity without talking about turmeric. Another powerful antioxidant and anti-inflammatory spice, turmeric is where curry gets its flavorand the antioxidant compound curcumin. In 2018, Dr. Small authored a small double-blind studyshowing that taking two 90 mg curcumin supplements daily for 18 months improved memory and attention in older adults with mild memory problems. We did find it has a significant effectcompared to placebo, says Dr. Small, who is currently expanding the research to a much larger sample size across the U.S. While hes not sure exactly how curcumin works to boost brain health, my best guess is its the reduction in inflammation, he says.

Robinette points out that turmeric has been called a natural immunomodulator, or a substance that helps keep the immune system in check by boosting immunity when you need it and tamping it down to prevent excess inflammation involved in many chronic conditions. Some research suggests that turmeric could potentially even play a role in preventing and treating cancer, cardiovascular disease, metabolic conditions, neurological disease, and skin diseases.

Although it certainly doesnt hurt to enjoy more foods with turmeric, youll need to pop a curcumin supplement to get the full health benefits of the spice. For therapeutic purposes, you want to take higher doses, says Robinette. Try to take the supplement when you eat your meals, preferably with fat (like fatty fish or nuts) to increase the bioavailability of curcumin. (Just check with your doctor before you start supplementing to ensure it doesnt interact with any health conditions you have or medications you take.)

Heres even more intel on all the benefits of turmeric:

Spirulina is a type of cyanobacteria (or algae) thats grown in water and sold as tablets or in powder form. It contains a high amount of protein for a plant. And with loads of vitamins, including iron, potassium, zinc, calcium, and B vitamins, its almost identical, nutritionally, to mothers milk, Robinette adds.

Given that following a plant-forward diet is key to healthy aging, Robinette says supplementing with spirulina can be beneficial for healthy aging. Nobody eats enough plants. Supplementing with something thats really concentrated like spirulina is acheat way to get more greens. Just be sure to check your spirulina comes from a clean water source. Aim for a teaspoon per day, says Robinette; since spirulina has a seaweed-esque flavor, she suggests tossing it into pesto or any savory recipe with greens, like salad dressings, soups, or dips.

Jalapenos, cayenne, and other types of peppers contain capsaicin, a chemical compound that makes food spicy and has antioxidant and anti-inflammatory properties. Dr. Small points to a 2015 observational study of nearly half a million people in China, which concluded that people who ate more spicy foods were less likely to die of all causesand specifically of cancer, heart disease, and respiratory diseasesthan people who didnt or rarely ate these foods. The authors concluded the effect may be due to capsaicin.

How often should you hit the hot sauce? The Chinese researchers found that the benefits of capsaicin were cumulative; people who ate spicy foods six or seven times per week were least likely to die of any cause. But eating spicy meals even a couple of times a week seemed to have some benefit.

There are only a couple dozen plant adaptogens, including ginseng, that help increase the bodys resilience to stressors of all kinds. While you might associate ginseng with Traditional Chinese Medicine, its one of the oldest medicinal herbs used all over the world to support human health, Robinette says.

Robinson explains that adaptogens like ginseng micro-trigger the body, so it gets stronger over time to physical, emotional, and environmental stressors (like light and sounds). Its not impervious to stress, but youre better able to recover and not overreact, she says. Its helping move you between the sympathetic and parasympathetic states with more ease. Many of us are dealing with some level of stress these days, which can, over time, suppress the immune system and even shorten your lifespan by contributing to inflammation in the gut and disrupting sleep. Chronic stress is counterproductive for longevity in many ways, says Robinette.

Like most herbs, ginseng has antioxidant anti-inflammatory properties, says Robinette. A wealth of research suggests ginseng may have immunomodulatory and anti-cancer properties, and that it may even help control blood sugar in people with diabetes and improve learning and memory. Unlike most of the other herbs and spices on this list, you really need to take ginseng every day for an extended period of time to see benefits, says Robinette. You can enjoy it in any form, including tea, powder, capsule, and tincturejust be sure to talk to your doctor first, as ginseng can interact with some drugs (like warfarin and insulin).

The powerful phytochemicals, or plant antioxidants, in blueberries helps clean up free radicals, fighting the effects of inflammation that can in turn impact your health and longetivity. There are studies showing antioxidant foods like blueberries or pomegranatesshow moderate effects [on oxidative stress], though not as consistent or as big of an effect as we saw with curcumin, says Dr. Small. While were waiting to support this science, it certainly makes sense to try to consume colorful fresh fruits and veggies.

Wild blueberries, in particular, tend to be highest in gut-boosting fiber and antioxidants, says Robinette: They have more skin than grocery store blueberries (which are still good for you but bred to be sweet). Eat them fresh, sprinkle blueberry powder into your smoothies and cereal, or spread blueberry (or any other superfruit) paste onto toast like thick jam.

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6 Longevity-Promoting Herbs and Spices To Add to Your Cooking Rotation - Well+Good

DUBLIN--(BUSINESS WIRE)--The "Stoma/Ostomy Care - Global Market Trajectory & Analytics" report has been added to ResearchAndMarkets.com's offering.

Focus on Stoma Quality of Life Paves Way for Increased Spending on Stoma/Ostomy Care Products. Market to Reach $3.8 Billion

The global market for Stoma/Ostomy Care is projected to reach US$3.8 billion by the year 2027, trailing a post COVID-19 CAGR of 4.2% over the analysis period 2020 through 2027.

The growth will be driven by rapidly aging population increase in the number of operative procedures involving creation of intestinal stoma and the resulting focus shed on stoma quality of life. World's population is rapidly aging supported by the increase in longevity as modern medicine becomes increasingly effective in preventing chronic disease, and reducing mortality. Also, easy access to age-friendly primary healthcare and growing sophistication of healthcare infrastructure play key roles in longevity.

For the first time in human history the percentage of older people in the total population is continuing to increase. In addition to the aforementioned increase in life expectancy, falling fertility rates are accelerating the trend. The aging population creates massive challenges for the healthcare system since it means larger chronic disease burden.

Among the many diseases of the elderly such as dementia; arthritis; blindness; chronic bronchitis; motor neurone diseases; osteoporosis; Parkinson's disease; stroke; CKD; and Alzheimer's, incontinence and bowel obstruction caused by colorectal cancer and other diseases that require surgical removal parts of the rectum, anus and colon requires the highest nurse care and self-care management needs. Colorectal cancer is the leading cause for creation of stomas/ostomy accounting for 45.6% of the prevalence rate. Juxtaposed with this fact, the high prevalence of colorectal cancer, over 60% of the incidence rate, among the elderly aged over 70+ makes aging population a powerful demographic growth driver for stoma/ostomy care products.

Colostomy is the most popular type of procedure performed on 45.2% of ostomy patients in the 60+ age group, while Ileostomy is the second most common procedure performed on people aged over 60 with over 38.7% of ostomy patients in the 60+ age group having Ileostomy. Urostomy is performed on 16.1% of ostomy patients in the 60+ age group. The ostomy market also benefits from the increasing survival rates from colorectal and bladder cancer. Mortality rate from these cancers has improved considerably during the past decades, both for women and for men. Resultantly, the increasing life expectancy of people bodes well for the ostomy care products market, considering the chronic nature of the conditions and the increasing need to use ostomy products. The annual ostomy product costs per patient are estimated in the range of US$1,000 to US$1,200 on an on average globally.

Prices of ostomy products remain stable due to fixed reimbursement levels. Caring for stoma is extremely important given the high risk and financial burden of complications following ostomy surgery. Lack of proper ostomy care is the leading cause for hospital readmission rates and ER visits in the United States second to kidney transplants. Over the years, rising awareness and improving standards of ostomy care have helped drive the market for stoma/ostomy care products.

The field of stoma care is also evolving and improving with stoma care emerging into a unique field in nursing. Popularity and easy availability of specially qualified stoma care nurses; development of best practice guidelines; easy access to new clinical insights and tools are all helping to deliver the best possible care for stoma patients.

Among the noteworthy trends in the global market for ostomy bags has been the increasing tender based and bulk purchases of the bags by large hospitals and healthcare facilities with huge number of inpatients on whom ostomies have been performed and also patients with fresh stomas. In order to maintain uninterrupted supply of these bags for better ostomy care for inpatients, healthcare facilities have been following the tender-based procurement of the bags.

Key Topics Covered:

I. INTRODUCTION, METHODOLOGY & REPORT SCOPE

II. EXECUTIVE SUMMARY

1. MARKET OVERVIEW

2. FOCUS ON SELECT PLAYERS

3. MARKET TRENDS & DRIVERS

4. GLOBAL MARKET PERSPECTIVE

III. MARKET ANALYSIS

IV. COMPETITION

For more information about this report visit https://www.researchandmarkets.com/r/4d7qea

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Global Stoma/Ostomy Care Market Trajectory & Analytics Report 2020: Focus on Stoma Quality of Life Paves Way for Increased Spending on...

Life expectancy has come to be the gold standard in assessing the health of a population, especially during Covid-19, where the Centres for Disease Control and Prevention and others advised the elderly to "shield" for months in isolation. Health services across the industrialised world have kept their citizens alive for longer, often adding more than a decade of life over the last two generations.

But as lifespan the total number of years someone will be alive has increased exponentially, healthspan the part of a persons life when they are in good health has largely stayed the same. This creates a huge crisis a demographic, economic and, above all, a humanitarian one. And it doesnt have to be this way.

A Chinese winter swimming enthusiast swims in a cold Houhai lake in Beijing, China, December 3. Winter swimming is popular among middle-aged and elderly citizens as they believe it can keep them in excellent health. EPA

Unhealthy ageing is a human tragedy. If governments and health authorities can focus on healthspans, not just lifespans, longevity technology can remedy it. Looking and feeling younger for longer is not the preserve of beauty brands or Silicon Valley billionaires. The science is real. It just needs investment, a favourable regulatory environment and health policies that are as focused on allowing people to live as much, rather than just keeping them alive.

The quality of life is just as, if not more important, than the length of life

The adverse health effects of ageing, just like high cholesterol or high blood pressure, is a risk factor for a variety of diseases. This means ageing should be treated the same way as any other risk factor that is, something to be treated and reduced. Health policy, however, has not always caught up with the science. Ageing is not an inevitable part of life that must be accepted. It is a technical problem that can and should be overcome.

It is no mystery that some individuals age better (healthier) than others. Now we know why: In 2006, the stem cell researcher Shinya Yamanaka identified four key proteins that seemed to turn the clock back on the ageing of cells, otherwise known as the "Yamanaka factors". This discovery was so profound that it led him to win the Nobel Prize. It has been hailed by some as the most important advancement since Francis Cricks discovery of the Double Helix.

But those discoveries havent always found their way into health policy. "Bio-conservatives" have resisted the notion of dramatically tampering with the ageing process, with some describing it as nothing more than billionaires' bid to buy their way out lifes only certainty: death.

Palestinian grandmother Jihad Butto, 85, celebrates obtaining a bachelor's degree in religious studies with her family at her home in Nazareth, Israel, on October 9. Reuters

Azra draws henna on her grandmothers hands in Dubai. Azra Khamissa is a Dubai based Canadian/South-African chiropractor, fashion designer, and henna artist, on August 1, 2019. Reem Mohammed / The National

This misses the point. Every new medical discovery is seen by some as "playing God", until the meaning of playing God becomes simply "being an effective Doctor". No one is saying that we should aim to live forever. And we can all agree that human life is sacred and should be preserved. But the quality of life is just as, if not more important, than the length of life.

This is something medics, investors, policymakers and the public should support because poorly managed ageing is a huge drain on global healthcare systems and economies. According to the World Health Organisation, the number of people aged 65 or older is projected to grow from more than 524 million in 2010 to nearly 1.5 billion in 2050.

If those people are economically inactive and hugely dependent on a constant stream of expensive medical procedures, economies will collapse. That strain is already huge. According to a report in the US by the Congressional Budget Office, the US Federal government spent 40 per cent of its budget, a total of $1.5 trillion, on elderly care in 2018. The same report predicts that by 2029, over half of Federal healthcare spend, approximately $3bn, will be spent on elderly care.

When populations grow older and the age of a society becomes an inverted pyramid, older people become increasingly dependent on a shrinking working-age population. That means higher spending and taxes for the young, which disincentivises them from working. The downward spiral caused by the symptoms of ageing is something that must be avoided at all costs.

Elderly people pose in clothes they have made themselves in front of a town hall in Hongseong, South Korea, November 24. EPA

Beyond the demographic and economic statistics lies human tragedy. Ageing and its associated diseases force children to watch their parents and grandparents slowly lose their independence. People who have worked their entire lives are robbed of the opportunity to enjoy their hard-earned retirement or to keep working. A couple can be robbed of their relationship if one of them is lucky enough to have the "good ageing gene" and the other isnt.

Regulators, healthcare providers and investors must work today to close the gap between healthspan and lifespan. While the average human lifespan has increased from 47 to 73 in seven decades, the gap between healthspan and lifespan is growing. It is predicted that the average global healthspan-lifespan gap is approximately nine years. Living for more than 10 per cent of our lives in relative suffering should be consigned to the past.

Health, as the WHO defines it, is a state of complete physical, mental and social well-being, and not merely the absence of disease or infirmity. This definition should serve as a north star. Regulatory bodies like the FDA should create an accommodating environment for anti-ageing patents, including gene therapies, to be developed and licensed.

Similarly, healthcare providers should also look to partner with private longevity providers to get the leading products onto market if we are to have a fighting chance at closing the healthspan-lifespan disparity.

This thinking is already there: The UKs National Institute for Clinical Excellence decides which medicines to fund based on how many "quality life years" they will create.

It is time to set the bar for quality of life much higher, based on the best science available.

Published: December 23rd 2021, 4:00 AM

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Scientists should be allowed to cure ageing - The National

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A new report from the Global Coalition on Aging (GCOA) and the Infectious Diseases Society of America (IDSA), a first of its kind known as the AMR Preparedness Index, provides an evaluation and roadmap for the 11 largest global economies and their efforts to tackle rising cases of antimicrobial resistance.

While recognition of the threat has risen, according to the organizations, there has been a broad failure to match public promises and actual actions to avert a crisis. The U.K. and the United States have fared best along with Brazil, Canada, China, France, Germany, India, Italy, Japan, and South Korea. Case studies were presented from Australia, Kenya, Russia, Saudi Arabia, and Sweden as well.

Increasing resistance to life-saving antimicrobials, together with our broken innovation pipeline, threatens to erode the very foundation of modern medicine and, with it, erase one of the principal achievements of the 20th century the miracle of human longevity, Michael Hodin, CEO of the GCOA, said. As the United Nations (UN) and World Health Organization (WHO) Decade of Healthy Ageing brings greater attention and energy to our remarkable demographic achievement and the COVID-19 experience make clear the compounded risk to older adults from infectious disease, we must fully acknowledge the threat that AMR poses to the very prospect of healthy and active aging. Without true action to effectively address AMR, tens of millions of lives both young and old will be cut short, and so many others will be diminished as a result of care foregone over concerns about now untreatable infection.

It is estimated that 700,000 people die each year from drug-resistant infections, and those figures are expected to grow as the problem worsens. Resistance is increasing to existing drugs, increasing the risk of even routine medical care.

If unaddressed, the continued rise of AMR is expected to lead to as many as 10 million deaths per year, disability and lower quality of life for millions more, and $100 trillion in lost GDP by 2050, the organizations said in a statement.

Countries were ranked based on seven categories. The results led the GCOA and IDSA to recommend several means of bolstering government action, as well, including:

The COVID-19 pandemic has made painfully clear to all the far-reaching impact of untreatable infectious diseases across societies and economies, Dr. Barbara Alexander, IDSA president, said. As we enter the next stage of the pandemic and with global momentum for AMR action building among G7 countries in the UK with the launch of the subscription pilot, and most recently, with the reintroduction of the PASTEUR Act in the US Congress the 2021 AMR Preparedness Index comes at a pivotal moment. We are pleased to partner with the Global Coalition on Aging to create this vital tool that will help governments around the world reinforce their words with actions.

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First AMR Preparedness Index finds UK, US top charts amid first world failures to address antimicrobial resistance threat - Homeland Preparedness News

First, it's important to note that everyone reacts to stress differently and you can't pigeonhole entire age groups. But generally speaking, research shows that your ability to manage stress isn't staticit waxes and wanes over time.

Part of this is inevitable and biological. Hormonal fluctuations during puberty and perimenopause can make us particularly susceptible to stress during these periods, for example. Past circumstances also play a role. Some people have had to go through more periods of stress and trauma than others, which can affect the way they react to hardship.

But interestingly enough, there is a growing body of research finding that our ability to regulate our emotions seems to improve with age. Take one study out of Stanford University, which included 184 adults of various ages. Starting in 1993, participants were asked to record their emotions (both positive and negative) multiple times over the course of a week once every five years. This data collection lasted 15 years, and the results were published in 2011.

At the end of the study, researchers found that, overall, self-reported emotional well-being increased with age. As participants got older, their outlooks also tended to even out and there was less variability between positive and negative emotions. And finally, those who experienced relatively more positive than negative emotions in everyday life were more likely to have survived over the study period, suggesting a link between emotions and longevity. "The observation that emotional well-being is maintained and in some ways improves across adulthood is among the most surprising findings about human aging to emerge in recent years," the paper reads.

Now, this study didn't focus on how stress, in particular, affects mood over time. But some shorter-term research focused on stress has also found that older adults tend to maintain a positive mood in the face of it than younger ones do.

Lifestyle physician and stress educator Cynthia Ackrill, M.D., suspects that this has to do with the widened viewpoint that age can bring. "You've been through a lot so you have a longer perspective to know that this too shall pass," she tells mbg.

AmyLorek, Ph.D., of the Center for Healthy Aging at Penn State Universityadds that, on average, older adults have accrued more self-awareness with time, giving them a better handle on their personal stressors.

"When we have a better understanding of our lives, we get better at selecting the things that are meaningful and important for us," Lorek says, adding that "older people actively opt out of things that are going to produce stress."

This may be true more generally, but again, Ackrill reminds us that stress is personal. While someone who has always practiced healthy stress management routines might find them strengthened with age, in her work she's seen the opposite to be true too. Someone with poor coping mechanisms might find that they have even more trouble handling stress as they get older. Some relaxing practices like exercise and social interaction can also become more difficult for older folks, especially if they have mobility issues or live alone.

The good news is that stress management is a skill that can always be trainedand it's never too late to practice it.

Read more:
The Link Between Stress & Longevity (And How To Stress Less As You Age) - mindbodygreen.com

People are fascinated by the extremes of humanity, whether its going to the moon, how fast someone can run in the Olympics, or even how long someone can live,says Michael Pearce from the University of Washington (UW) in the U.S., who recently led a study that estimates with almost a 100% probability that the present record for maximum reported age at death 122 years, 164 days will be broken by 2100.

And with a continuous expansion in the world population, the likelihood of breaking records is only rising, the researchers believe.

Published in Demographic Research, their study assessed the extremes of human life by studying longevity records of more than a thousand people from 13 countries across the world, as well as of almost 14,000 individuals, who died between the ages of 105 and 109. Using statistical modeling to analyze the data, the researchers found that a lifespan of 125 years, or even 130 years, is possible in his century.

Basically, the researchers based their findings on two factors: how the risk of dying flattens after age 110, and growth in the number of people to reach age 110 this century, according to an article in The Conversation by Pierce and his co-author on the study, Adrian Raftery, who is a professor of statistics at UW.

Related on The Swaddle:

Graying of Hair Due to Stress May Be Reversible, New Study Finds?

On the one hand, life expectancy is on the rise globally due to advances in healthcare, and due to these same advancements, the researchers believe there is a flattening of the mortality rate after people reach a certain age someone who hits 110 has the almost same probability of living another year as someone reaches the age of 114.

This is a very select group of very robust people, Raftery explained, adding that if theyve gotten past all the various things life throws at you, such as disease, [then] they die for reasons that are somewhat independent of what affects younger people.

However, it may be pertinent to note, here, that the study is based on data gathered before the pandemic hit, and claimed more than 43 lakh lives globally. And, in any case, as the researchers clarified, the maximum is not the average, and just because we may break records by the end of the century, doesnt mean everyone or even most people will live to be 110.

A study from June had found that while we may live longer now, we cant really slow the process of aging in any manner. Our findings support the theory that, rather than slowing down death, more people are living much longer due to a reduction in mortality at younger ages, Jos Manuel Aburto, one of the studys co-authors from the Oxford University, had told The Guardian.

Yet another study from May had found that even if a person manages to avoid dying of heart disease, cancer, or road accidents, the human bodys structural and metabolic systems do fail beyond a point that lies between 120 to 150 years; making 150 years the absolute longest a human being can live.

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Scientists Say Gut Microbes May Reverse Aging Process in Human Brains

But so many studies on the subject of human lifespans beg the question: what drives our desire to live longer especially at a juncture when climate change is expected to make life difficult in myriad ways?

Experts believe it could be because we dont understand death. So the prospect of not living triggers a kind of FOMO. The quest to live forever, or to live for great expanses of time, has always been part of the human spirit The most difficult and inscrutable thing to us as mortal beings is our own death We dont understand it, we dont get it, and as meaning-laden beings, we cant fathom what it means to not exist, Paul Root Wolpe, an American sociologist and bioethicist, told Time.

As for people like Teslas Elon Musk and Googles co-founder Sergey Brindriving researchin increasing longevity to the point of, perhaps, being immortal, ego may be an important factor. Obviously they believe the world cant possibly survive without their existence, and so they think their immortality is so critical to the survival of the world, Ezekiel Emanuel, an oncologist and bioethicist, said.

Wolpe, however, notes that younger people have a harder time [dealing with the idea of dying] compared to older people. My youngest is upset that I do not want to be frozen and woken up in the future, Suzanne Moore, a columnist for The Guardian wrote last year.

According to Wolpe, older people dont care about living as long as younger people do because living longer doesnt make aging slower just as the study from June proved. What you see when you actually look at people at the end of life, to a large degree, is a sense of a life well-lived and a time for that life to transition itself, he notes.

Read more:
People's Lifespans May Increase In the Future. Why Do They Desire Longer Lives? - The Swaddle

Mark Allen, CEO of Elevian, pictured above. Photo courtesy of Elevian.

Once the domain of mythical fountains of youth and movies like The Curious Case of Benjamin Button, the science of aging prevention and reversal is beginning to enter the mainstream with reputable academic institutions launching companies to accomplish this once improbable feat.

One such company,Elevian, founded by a team of Harvard scientists and physician-turned entrepreneurDr. Mark Allen, is working to restore regenerative capacity with the aim of preventing and treating age-related diseases. A critical factor, they say, is a single protein called Growth differentiation factor 11 (GDF11).

Allen, Elevians chief executive officer, first became interested in the science of aging after taking a course focused on exponential thinking.

All of a sudden, problems that were heretofore unsolvable become solvable, Allen said of the theory that is the opposite of incremental and encourages one to think outside of the box. They talked about examples of problems that weve always thought to be unsolvable, one of them being aging and longevity. So that was it for me. I was like thats perfect for me. Thats what I want to work on.

Searching for clues into the diseases associated with aging, Elevians founders, including Harvard professor of Stem Cell and Regenerative BiologyDr. Amy Wagers, mined the proteome, looking into how proteins change with age. They uncovered several, including one with potentially groundbreaking regenerative capabilities, GDF11.

Elevian believes that this single protein, a key player in the circulatory system, could be a game-changer in regenerative medicine.

GDF11 is one of those proteins that change with age, Allen said.They [the founders] really dug into GDF11 because so little was known about it at the time of their discoveries. They did side-by-side studies with the parabiosis model, injecting just GDF11, to see if it could reproduce some of the effects of parabiosis in the aged animal. And they found, much to everybodys surprise, that replenishing just this one circulating factor was able to reproduce many of the beneficial effects of parabiosis.

Parabiosis, which means living beside, is performed by joining two living organisms surgically to develop a single, shared physiology. It has been used to study conjoined twins, and more recently, in a 1972 lifespanstudyattaching old and young rats, scientists Frederic C. Ludwig and Robert M. Elashoff showed evidence of an extended lifespan for the older animals.

As a post-doc at Stanford, Dr. Wagers expanded upon this research using modern histology techniques. When Wagers and her colleagues attached the circulatory systems of young mice to old ones, they found strong evidence of a biological reversal of many characteristics of aging. Later, Dr Wagers and colleagues discovered that injecting only GDF11 in aged animals can reproduce many of the benefits of parabiosis, in apaperpublished in Science in 2014 and recognized as arunner-upto the publications Breakthrough of the Year.

What they found is that the old animals exposed to young blood experienced a biological reversal of aging by many different measures. Their brains grow younger, their hearts grow younger, their lungs, their bones all over their body. And interestingly, the young animals exposed to old blood have accelerated aging. So this is just really strong proof that circulating factors regulate aging, said Allen.

The mechanism of action appears to be that GDF11 binds directly to endothelial progenitor cells that line our blood vessels and improves both the quality and quantity of the vasculature. It does not cross the blood-brain barrier, so we think its mechanism is primarily by improving vasculature, he explained.

Elevian, the recent beneficiary of an initial round ofseed financing,is actioning this potent protein to develop a potential regenerative treatment for stroke patients.

English biomedical gerontologistAubrey de Grey, whom Allen credits with doing a lot to start the medical field of aging reversal, outlined several hallmarks of aging in his 2007 book, Ending Aging. These include stem cell exhaustion, protein aggregate buildup, failed intercellular communication, and senescent cells.

One of the barriers to developing therapeutics based on these factors is the inherent incongruence with the usual regulatory approval systems. Following customary protocol, proving that a drug prevents aging or age-related diseases would quite literally take a lifetime.

Theres no regulatory path for treating aging. Even doing a prevention trial would take years and years and years, because you have to take people and wait until they get disease to see effects. So instead, to get a drug to market, we take the opposite extreme. We look at what is the most devastating possible disease, unmet need, where we could treat for the shortest possible duration and see clinically meaningful effects, Allen explained.

Elevian decided on stroke, which is thenumber two causeof death worldwide and the third leading cause of disability.

The only existing treatments for a stroke are limited to the acute phase, where an IV injection of a drug such as recombinant tissue plasminogen activator (tPA) (Activase)restores blood flow by dissolving the clot causing the event.

In an ischemic stroke, which makes up87%of cases, a blood clot forms and prevents blood and oxygen from reaching an area of the brain, impacting breathing and heart function and often leading to paralysis. This is where Elevian believes a drug utilizing GDF11, which acts on the circulatory system, holds such promise for rehabilitation.

Allen revealed that his team has already demonstrated GDF11s impact on stroke-stricken animals.

When we give GDF11 to animals that have had strokes and are paralyzed or have severe motor function debilitation, it returns them almost to normal function. It significantly improves motor function recovery, he said.

On the strength of these preclinical results, Elevian is gearing up to enter human clinical trials with GDF11 for the treatment of stroke.

We really got the green light to go into humans based upon the animal data that we got there, Allen said, adding that there is still a lot of work to be done before they reach this phase. We still have to scale up production of the drug and we have to do extensive safety and toxicology tests IND-enabling studies. The longest pole in the tent is figuring out how to make manufacturing costs effective. The cost of goods is going to be really, really high. So were doing a lot of work in process development right now, and then were going to hand it off to a manufacturing partner to scale up. Were about two years from initiating our human clinical trial in stroke.

Another unmet need where Elevian believes GDF11 can have an impact is Type 2 diabetes, a disorder whose pathology is also intricately connected to the circulatory system and often to aging.

Along with blood clotting factors, glucose resides within the inside lining of blood vessels. InType 2 diabetics, the lining of an individuals blood vessels begins to become glycosylated, which causes them to narrow, impeding blood flow. Glucose tolerance is known to decrease with age.

In a study published in March 2020, Wagers and her colleagues stated that GDF11 was shown to significantly improve glucose tolerance in aged mice and increase glucose homeostasis, under a variety of dietary conditions.

Allen believes that addressing the aging process is the ultimate exponential strategy to solving a whole host of humanitys biggest killers:

This idea that we could, by targeting the aging progress, potentially promote healthy aging, promote a healthy longevity, and reduce the burden of age-related diseases, and that the same treatment could be used to treat and prevent multiple age-related diseases. That concept was like, why arent we working on that? Why are we spending billions of dollars on Alzheimers and billions of dollars on cancer, billions of dollars on heart disease? We could instead target the aging process and potentially treat them all.

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Elevian Targets Aging to Solve Humanity's Toughest Diseases - BioSpace

How do you measure the risks of pandemic travel, and when will the time be right to go again?

We asked five infectious disease experts, including one who hadnt left home in four days, one who has taken two Mexican vacations since March and one who recently awakened from a COVID/Disneyland nightmare.

The first thing we must do, they agreed, is stay close to home for at least several more months, get vaccinated, and watch virus transmission and ICU numbers closely. Putting down the pandemic in California and elsewhere, they said, will depend on how faithfully we use masks, keep our distance and wash our hands habits that will remain vital as authorities strive to vaccinate 300 million or more Americans by summer.

I will never get on an airplane again without a mask, said Dr. Kimberly Shriner, an infectious disease specialist at Huntington Hospital in Pasadena.

Now is not the time to be traveling. For leisure or business, said Dr. Luis Ostrosky, a professor of infectious diseases at McGovern Medical School at UTHealth in Houston.

If you fly now, said Dr. Krutika Kuppalli in Charleston, S.C., you can almost guarantee that there are going to be people on the airplane with you who have COVID.

These experts all are wary of new variants of the virus. None is flying now. Three have spent recent months within 120 miles of their home, as authorities urge all Californians to do. (That advisory remains in place, despite Gov. Gavin Newsoms loosening of many restrictions on Jan. 25.) But their perspectives vary.

Ostrosky, born in Mexico City, has a lot of family there. So when his grandmother died recently, he thought about making the trip south. Mexico is one of the few countries Americans can visit without a mandated quarantine.

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But he didnt go because of the pandemic. After much talk, he stayed put in the U.S. Before he resumes travel, he said, hell ask several questions.

Whats the positivity rate? I would avoid traveling to any place that has a positivity rate over 5%, he said. Above that, you dramatically increase your chances of exposure. Californias seven-day average positivity rate the number of COVID tests that yield positive results was 12.4% on Jan. 27.

How full and how capable are the hospitals? Scores of U.S. hospitals are at surge capacity, with shortages of ICU beds. Because most county governments report COVID information daily, Ostrosky said, its actually pretty easy to find data. As for capability, any hospital with a Level 1 trauma center (the most comprehensive trauma care) would satisfy him, Ostrosky said. The American College of Surgeons maintains a database.

Does this destination require testing to enter or leave? Many travelers might hope for that, but I just dont want to get stuck somewhere, Ostrosky said. People can test positive for a long period of time without being infectious.

This is now a factor in any flight to the U.S., including returning round-trip flights. As of Jan. 26, the U.S. Centers for Disease Control requires all air travelers to show a recent negative COVID test result before they can board any flight heading to the U.S.

Shriner, who also is a tropical disease specialist and director of the Pasadena Travel Medicine clinic, has been vacationing in Europe for years and has spent more than 20 years making regular visits to a medical project in Tanzania.

But at Huntington Hospital, ever since the holidays, were just absolutely getting hammered with cases of people who traveled, she said.

Outside the hospital, Shriner has done some driving around California, but hasnt flown since March. Like her colleagues, she believes that driving (especially if you bring food and avoid public toilets) is safer than flying and much safer than cruise ships (most of which are idle now).

Like Ostrosky, she wants to see a positivity rate of 5% or less at her departure point and at her destination. For data, she recommends the Johns Hopkins University Coronavirus Resource Center.

Shriner likes the idea of airlines and destinations requiring negative test results or vaccination. Whether or not those are required, Shriner said, people should get vaccinated, wait at least four weeks (to allow resistance to strengthen), and consider their age and immunity history before making travel plans.

In darker moments, she said, she worries that this could just go on for another year or two if people dont widely accept the vaccine. She also shared a recent nightmare: She was on the Pirates of the Caribbean ride at Disneyland (which remains closed) surrounded by unmasked strangers.

On the brighter side, shes hopeful that travel might be safe as soon as late summer or early fall. But it is all dependent on human behavior, Shriner said, and we know how unreliable that is!

Kuppalli moved in August from the San Francisco Bay Area to Charleston, where she is an assistant professor in the division of infectious diseases at the Medical University of South Carolina. She grew up in the Bay Area and had planned to visit her parents there this month.

Then the numbers surged. I decided not to travel, she said in mid-January. I havent left my house in the last four days.

To assess risk, you cant look at one particular piece of information, she said. You have to look at the entire thing. ... I totally get that this is hard for everybody. But this is not the time to travel. We all need to be thinking not just about ourselves, but everybody.

Before Dr. Nancy Binkin became a professor at the Wertheim School of Public Health and Human Longevity Science at UC San Diego, she lived for 12 years in Italy, doing epidemiology training for the Italian National Institute of Health.

So when that countrys fatalities soared in the early weeks of the pandemic, followed by escalating U.S. numbers, it put fear into me, Binkin said. I have not been out of San Diego County since March.

One pandemic number she watches closely is the adjusted case rate. That count measures the seven-day average of daily new cases per 100,000 people (jails and prisons excluded). Any number above seven per 100,000 puts a county in the states most dangerous category, the purple tier. On Jan. 27, Californias statewide rate was 71.6 per 100,000. Before she travels, Binkin wants to see that number below seven.

When it comes to flying, she worries about jet cabins and tiny bathrooms, but perhaps even more, she worries about the lines of people and gathering points at airports, she said.

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Would I feel comfortable going down to Mexico? No, she said. I wouldnt.

Dr. W. David Hardy, former director of Cedars-Sinai Medical Centers infectious diseases division and adjunct clinical professor at USCs Keck School of Medicine, has mixed feelings.

Hes angry about rampant disregard for science and inconsistent messaging under the Trump administration. But Hardy sees great hope in the vaccines.

When he was treating HIV patients during the grimmest years of the 1980s, Hardy recalled, there was no such cause for encouragement.

To have a vaccine [that prevents] 90-95% of people from getting sick is amazing, Hardy said. He suggests that the vaccines are going to be the final answer, especially if the vaccines thwart transmission of the virus as well as block symptoms.

Yet the metrics for measuring transmission are ever changeable, and it may be difficult planning travel based on those, he said. They are going to be fluctuating for a while. I would say from six months to a year.

Since March, Hardy said, he has scrubbed trips to Europe, North Africa and Hawaii. But in September, after Californias first surge had passed, Hardy and his partner flew to Los Cabos, in Baja California, for a vacation. It went well. So in December Hardy and his partner flew again, this time to Cancn and Playa del Carmen on Mexicos east coast, where they found the local people there were using masks religiously.

The other visitors? Not so much.

I would say 50-60% of the tourists were completely ignoring the mask requirements.

Most of them were Americans, Hardy said, and he began asking people to put on their masks or if they had no mask, to step away from where I was standing.

The whole experience was confusing and disconcerting, he said. When I got home from my second trip to Mexico, I turned to my partner and said, This is not a good time to travel. People are not adhering to what they should be adhering to.

In some respects, Hardy said, that behavior reminds him of the 1980s when HIV was new. Then as now, he said, until one of your friends, family or work associates dies of this disease, you still look at it as a sort of distant thing that doesnt affect you.

Link:
When will COVID travel safety improve? 5 experts weigh in - Los Angeles Times

By TEE NGUGI

I was amazed to hear Yoweri Museveni lamenting about foreign interference in the internal affairs of Uganda. These fellows, he said, in reference to foreign news networks in particular and the West in general, have a primitive culture that allows interference in other peoples affairs. He intimated that African culture would never allow him to interfere in other peoples business.

Now, this was exactly the sentiment voiced by African leaders in the 1980s when they were faced with agitation for a return to democracy. They castigated news networks and the West for trying to impose a foreign ideology on otherwise peace-loving Africans. Democracy, they said, was a system alien to African culture, because it was adversarial while African traditional democracy was consentaneous. They dismissed those calling for democracy as foreign stooges.

Human rights originations, such as Amnesty International, were accused of trying to bring about a re-colonisation of Africa.

When Museveni took power in 1986, he represented a new kind of leadership. He brought stability to a country ravaged by murderous chaos for decades. He revived an economy ruined by corrupt regimes, beginning with Milton Obotes in the 1960s. In the rest of Africa, his progressive ideas were a beacon of hope on a continent in the vicious grip of tyranny and consequent poverty. He supported progressive forces in Kigali when the rest of Africa looked the other way. Likewise, he gave support to forces attempting to overthrow Mobutu Sese Sekos rapacious dictatorship.

Kenyan dissidents, facing death or jail, found safe passage through Uganda. He memorably called the Organisation of African Unity, the predecessor body to the African Union, a trade union of dictators. He advocated for a new Africa where leaders served the people, not their stomachs. He did not object when the West and human rights organisations, which he now criticises for interfering in the internal affairs of Africa, praised the new breed of African leadership he represented.

But oh, how years at the top change everything! Critics and oppositions members like Bibi Wine are regularly arrested. Elections are accompanied by intimidation and violence.

In the region, Museveni is a defender of the old order. He is now an ardent supporter of the AU which, like its predecessor body, looks the other way as leaders terrorise and impoverish their citizens, but is quick to condemn ill-treatment of African-Americans in America. Museveni, who once said that the problem of Africa was leaders not wanting to leave power, now says that longevity in power has made him an expert in governance.

Now, if he Museveni were a Lee Kuan Yew, the man who presided over Singapores spectacular rise, perhaps his longevity in power could be justified. But like last weeks column argued, his continuation in power is detrimental to the economic and social welfare of Uganda in particular and Africa in general. Who would have thought back then that Museveni, like Mugabe, would transform from liberator to oppressor.

Tee Ngugi is a Nairobi-based political commentator

View original post here:
Oh! How the stay at the top has changed Comrade Museveni - The East African

HE may not be quite as old as his cartoon namesake but at the grand old age of 26, Snoopy could well be Scotland's oldest cat.

The hardy rescue moggy, who has clawed his way up the equivalent of 120 human years, was discovered abandoned and 'near feral' in the gutter and was the runt of the litter, according to his owner.

However, the six-week-old kitten thrived under the care of his new family and even overcame cat flu - which can often be fatal in felines.

The average lifespan for a domestic cat in the UK is 14 with animals described as geriatric if they survive beyond 15.

Snoopy may be frail but apart from losing his hearing he has no other health problems and is now enjoying the high life with the odd potter around the garden and regular helpings of his favourite meal of mince and tatties.

READ MORE: Donations pour in after death of wildcat kitten Huntleigh

His owner Lorraine Leskovec, 57, says she's amazed by his longevity - he's survived three other, younger cats.

"I've always felt that when I've lost other cats that they have left a bit of themselves in Snoopy," she said.

"He's a good old boy. As far as I remember, I had been looking for a kitten for a wee while and phoning the cat and dog home because at that time they were hard to get.

"They phoned me one morning to say they had a litter of kittens in. So we went down and there was a wee one that kept hiding in the corner and he was the runt of the litter and I thought that's the one I'm having.

READ MORE: Huntleighthe rescued wildcat kitten passes away

"He used go outside a lot but now it's just now and again. In the Summer he loves to finda sunny spot but not in this cold weather, he's too frail now.

"When he was younger he was quite robust, he was quitethe cat of the town," added Snoopy's owner, who lives in Carnwath, near Lanark andhas another Ragdoll cat called Rocky, who is blind.

"His appetite has gone through the roof but I think that is part of being an older cat. At the moment he will eat everything from mince and tatties to cheese. He gets what he wants now."

Cats may not really have nine lives, but factors such as diet, healthcare and environment can have an impact on how long they live.

Older catsgenerally succumb to illnesses such as kidney disease, arthritis, congestive heart failure, liver disorders, and renal disease.

READ MORE: Cat missing for 12 years re-homed after living as a stray on the shores of Loch Lomond

The oldest cat ever, according to the record books was called Creme Puff. It was born on 3 August, 1967, and lived for 38 years and three days.

"I would never have thought he would have lived to this age, " said Ms Leskovec, who works for Tesco.

"He's an amazing cat. Every day I say to my partner, 'IsSnoopy still breathing?' I'm hoping he will just slip away when the time comes."

See the original post:
Is this Scotland's oldest cat? | HeraldScotland - HeraldScotland

I began to write this essay in January 2020, what feels like years ago. The issues I wanted to raise are no longer even partly hidden. The effects of racism on the body, especially the black body, are in plain sight.

Most of these problems have been there for centuries, but are now called pandemics. Pandemics of murder, of disease and of social inequality. In the face of new waves of deaths, including those that precipitated the Black Lives Matter movement, the world is reawakening to the power of racism to kill people.

The Effects of Race Project at the Stellenbosch Institute for Advanced Study started in 2013. The goal of a team of academics was to better understand the everydayness of race and how race-thinking created durable and seemingly inescapable racialised realities in South Africa, the US and elsewhere.

Race thinking the idea that people belong to a race determined mostly by their skin colour has so framed our realities that we can scarcely imagine a world without it.

But race thinking has deformed us and society because its based on constructs of otherness and difference. These, in turn, underpin expectations of character, intelligence, motivation and behaviour. They can pave the way for the unleashing of suspicion, derogation and dehumanisation.

Racism affects health and often leads to early death. We now know in greater and more disturbing detail how this occurs. It kills directly and abruptly when people are murdered by police or vigilantes, but it also kills through disease. COVID-19 is new, but diseases common to the survival zones of the urban poor have been with us for a long time. It was only a century ago that the bone disease rickets was so common among African American children of eastern US cities that it was considered a rite of passage.

More sinister even are the health problems caused by acute and chronic stress on people who are subjected to racial othering and overt racial discrimination. The trauma of humiliation caused by racism creates recurrent stress in individuals, families and wider communities. These stresses manifest in manifold ways, and often transcend generations.

Racism has been described by sociologist Gran Therborn as an existential inequality that diminishes or denies agency and personhood. But racism is also a vital inequality in his classification because it shapes the human life course by determining life expectancy and overall health and well-being.

Racism operates at multiple levels to negatively affect health. Physical violence and rampant infectious diseases are the tip of the iceberg. Institutional racism negatively affects access to health services and healthy lifestyle choices by creating neighbourhoods or districts where people cannot thrive.

And when members of stigmatised racial populations respond to the pervasive negative racial stereotypes by accepting as true the dominant societys beliefs about their biological and cultural inferiority, they can internalise the racism. Internalised racism manifests itself in many ways. It leads to lower self-esteem and psychological well-being.

When people are worried, day in and day out, about their safety, their future, and how they are being perceived by others because of racism, they experience stress and anxiety from recurrent humiliation. These effects are not transient, nor merely psychological.

Its been known for years that the psychological stress attendant with racism has, for example, a significant effect on the development and progression of atherosclerosis, a precursor to serious heart disease. This outcome arose from a lifetime of experience.

But the full weight of psychological and physical damage caused by the chronic stress of racism is only now beginning to be fully understood.

The social context in which a child lives is a powerful predictor of their adult health. It can also affect their genes, in ways that are only now being recognised.

One of the most disturbing set of discoveries in the field of epigenetics is stress can affect the way an individuals genes work, and that some of the stress-related changes can be inherited.

Epigenetics is the study of changes caused by modification of how genes work rather than by altering the genetic code itself. Epigenesis is the transmission of information to new cells during cell division that determines how genes are expressed which genes present are turned on and which are silenced.

Read more: How the dimensions of human inequality affect who and what we are

Studies of epigenetic changes can illustrate the specific biological mechanisms by which social conditions become physically embodied. What we are now understanding is how feedback loops are established by early life stressors causing negative emotions which cause biochemical and physiological changes. These in turn cause changes in behaviour that alter the chemical environment in which genes are being expressed.

The chain of events from genetic modification to behaviour is long and there is no predetermined conclusion, but the mere fact that this can happen is profoundly disturbing. That some of the genetic changes may be inherited is even more so.

When we grasp the reality that human bodies and genes are being constantly remodelled by the physical and social environment and by life experience, the inescapable conclusion is that we must fight the origins of health disparity at their root, in the early social environment and life experiences of every person.

Its incumbent on all governments to recognise the seriousness of epigenetic influences on human well-being, especially in early life. Findings such as these should be used to promote widespread social reforms that fight the larger geographic, sociocultural, economic and political contexts in which health disparities are embedded.

Read more: We need to unpack the word 'race' and find new language

In short, the development of a healthy citizenry depends on people growing up with adequate nutrition, protected from violence, gross insecurity and humiliation, and raised in environments conducive to the development of emotional security. We have known for a long time that poverty, poor nutrition, child abuse, trauma and fear were bad for health.

What epigenetic research offers is the shedding of light on the biological pathways through which such exposures are translated into concrete, measurable, increased risks of various diseases such as bipolar disease, asthma, adverse birth outcomes and the now widely recognised problem of decreased longevity.

Understanding how genes are differentially regulated by experience will affect how we conceptualise social inequalities and health disparities.

Rather than engaging in outdated nature vs nurture debates concerning race as a genetic or social construct, considering race as an epigenomic construct may be the most accurate and appropriate perspective yet.

The real world is the one in which we understand genes and the socially experienced world as perpetually entwined in the human body.

This article is part of a series that has been running for seven months. Other authors include Barney Pityana, Gran Therborn, Njabulo Ndebele, George Chaplin, Kira Erwin and Kathryn Pillay.

The three edited volumes of essays published by African Sun Media in 2018 (The Effects of Race, edited by Nina G. Jablonski and Gerhard Mar), 2019 (Race in Education, edited by Gerhard Mar), and 2020 (Persistence of Race, edited by Nina G. Jablonski) contain the complete representation of the projects scholarship.

Here is the original post:
Racism has a physical impact on the body -- here's how - The Conversation CA

Editor:

Im writing in response to Rich Lowrys December 31 opinion piece on the climate crisis.

His premise is that climate change does not pose an existential threat to humanity and that its preposterous for President Elect Biden to make that claim. His reasoning requires that we equate existential threat with the threat of human extinction. Then he outlines what in fact are the existential threats of climate change as the reasons why humans wont go extinct. When sea level rises, we move inland. When temperatures continue to rise, we deploy more air conditioning. When droughts persist, use less water. Theres really nothing to worry about. Humancleverness will save the day.

He then shifts gears. There really isnt anything bad happening now. The world has been getting warmer for decades (currently 2 degrees F above the 1895 2015 average) with no adverse effects on human population or longevity. Here he dismisses all the unprecedented wild fires, hurricanes producing hundred year rain totals, and record droughts and floods by criticizing the President Elect for claiming that they are caused by climate change. We all know the difference between climate and weather and have heard the scientists insist that any given weather event cant be directly attributed to climate change. But I invite everyone to step back and look at the totality of weather related disastersover the past 5 years and draw your own conclusions.

Even Mr. Lowry concedesThere is no doubt thathuman activity contributesto climate change. So,what is Mr. Lowrys plan while the world puts 32.5 billion metric tons of CO2 into the atmosphere annually (US share 5.1 billion) and the average global temperature rises 1/20 degree F per year? ...seek to understand better and prepare to address through adaptation and innovation should the worst come decades from now. And whats President Elect Biden proposing? According to Mr. Lowry to suspend all rational thought-especially the downsides of costly measures to crimp the US economy in the name ofsaving the planetMr. Lowry doesnt saywhat these costly measures are. Here are a few: encourage sustainable energy alternatives, revamp the electrical grid, require more energy efficient buildings, institute more sustainable agricultural practices, encourage the move to electric vehicles, make conventional vehicles more efficient, maybe start planting trees like mad. The list is endless. The article claims we are an innovative species.

Do we follow Mr. Lowrys advice and sit and contemplate our navels while digging up the Canadian wilderness to get at the tar sands, etc etc i.e. business as usual, or do we start doing what we know must be done and what President Elect Biden is proposing.

Jim DeFelice, Richmond Hill

The Bryan County News welcomes letters to the editor. Letters cannot be libelous, must be factual and should be brief, typically 250 words or less. Letters may be edited for length, accuracy and clarity, and are limited to two letters per writer per month. No unsigned letters will be printed. Contact information, including the writers address and telephone number must be submitted with letters. We make no guarantee your letter will be published, though we will make every effort to print those meeting our guidelines. Send letters to editor@bryancountynews.com.

Link:
Letter to the editor: Lowry's take on climate wrong - Bryan County News