Will Wainwright wear a red jacket AND be invited to Cooperstown, or just one? I examined the veteran Cardinal after another vintage performance.

ST. LOUIS Adam Wainwright is going to own a red suit one day.

That is already cemented in stone, an announcement simply waiting for the pitcher to hang up his cleats. Perhaps Wainwright could be the first member to keep pitching even though he sits in a Hall of Fame. He'll get there as a Cardinal when it's all said and done.

But what about Cooperstown? Cardinal Nation asked this recently with Jim Edmonds and Scott Rolen, a pair of great Cardinals who came up short due to overall career statistics or unfortunate injury. Edmonds had a couple very good bursts of MLB action. He put together a six years stretch that is MVP-like. Rolen suffered a shoulder injury with the Cardinals that affected him the rest of his career. Is it the same case with Wainwright?

For Wainwright, the injury bug will most likely keep him out of MLB Hall of Fame contention. He'll get on a ballot with his two rings, and near 180 career wins with a moderate amount of dominance-but I wouldn't expect an introduction at Cooperstown.

And it's okay. The list of great pitchers who aren't in the Hall runs for miles. A particularly interesting case is Dwight "Doc" Gooden. He spent the majority of his career with the New York Mets, gathering 194 wins and a Cy Young award along with many other trophy accumulations. But his 16-year career is not in the Hall of Fame. A very good pitcher who simply didn't dominate for long enough.

Wainwright was robbed of nearly two seasons by the Tommy John surgery in 2011 and Achilles tendon rupture in 2015. If he gets 15-20 wins in those seasons, he easily over 200 wins at the moment. That win mark would seem to the opening of the conversation for a Hall of Fame stop. 300 wins is a sure thing, but 200 gets the ball rolling for pitchers.

This isn't a shot at Wainwright's career. Talk about a storied trip that should spurn stories and legends for decades to come. Coming to St. Louis in a big trade with the Atlanta Braves as a starter, but hitting it big with the team initially as a closer.

When Jason Isringhausen's hip worsened and his save percentage dropped in 2006, it was Wainwright flying in to the rescue, and throwing the final pitch of the playoffs that year. If anyone forgets to mention Wainwright freezing Carlos Beltran during the NLCS that fall, please rewrite their list for them in a hurry.

2007 found him as a full time starter, and it took two years for Wainwright to become an ace. He won 19 or more games in four different seasons. In three different seasons, Wainwright gave the Cardinals more than 227 innings. He was a boss for five seasons, with the worst one coming right after his arm surgery in 2011.

In four seasons, Wainwright was a top three finalist for the Cy Young award, and he gathered top 20 MVP votes in three seasons. He also owns a 2.81 ERA in 27 career playoff games, 14 of which he started. When the team needed a lift, Wainwright was there.

The Achilles incident really cost Wainwright. The Tommy John surgery was unfortunate and stopped a good run, but he had come all the back from that before the injury in Milwaukee that cracked his career in half. Since that injury, Wainwright has never finished with an ERA below 4.00.

But the good thing is, these days offer a place for pitcher who can keep the number right around 4.00. Right when you thought it was getting real close to the end in 2018, Wainwright made another comeback, the second of his career. After signing a one year contract packed with incentives, Wainwright offered the team 31 starts, 172 innings, and a 4.19 ERA last season. He was also one of the best arms in the playoffs, including 11 strikeouts and just one walk against the eventual World Series champion, Washington Nationals.

Wainwright keeps finding new ways to produce results. He kicked off 2020's weird yet fun season with a win on Saturday afternoon, shutting down the Pittsburgh Pirates for six innings. The only run he allowed, along with five strikeouts and just three hits, came off a generous call from the home plate umpire. Just like he mastered last year, Wainwright is using his location skills and brain to out-think hitters.

Think about it. He's always been a bulldog on the mound, raising the tenacity and no quit limits to the highest levels possible, pushing himself into his 15th year as a Major League pitcher. Wainwright doesn't have the overpowering fastball these days, and his curveball can be deadly but also suddenly become hit and miss in its existence. He's found new ways to get outs in order to extend his career.

So, why talk about the Hall of Fame all of a sudden? There's a variety of ways to answer that question. The first is that, like it or not, Wainwright is near the end. It will be a sad day in this town when he no longer climbs a pitching mound and plays catch with Yadier Molina. Wainwright turns 39 in August, so he can only go on for so long.

Another way would be to say I saw a tweet and it made me think for a few minutes. The lovely and esteemed baseball writer Chelsea Ladd put something out that got people talking. Here it is:

Now, let me acquit Ms. Ladd by saying she added in a follow-up tweet that she never meant to say he belonged in Cooperstown. Like me, Ladd thinks he is a sure-fire Cardinals Hall of Famer. He will get a red jacket after he retires.

And that shouldn't be a cheap alternative to the Hall. Think about it. Gooden was inducted into the Mets Hall of Fame in 2010. Like Wainwright, he had a few seasons where he was lights out, but after 6-7 seasons in New York, Gooden lost his magic and simply tried to get outs for the rest of his career.

For my money, the Hall of Fame is the top of the mountain for athletes. It's a recognition unlike any other. But if you asked Wainwright if he'd hand over his two World Series rings for a spot in Cooperstown, I'd like to think the answer would be quick and painless. Wainwright found his own brand of legend in St. Louis, a longevity most pitchers don't get to experience.

Let's face it. It's becoming a certainty that Wainwright is going to finish his career in St. Louis. I doubt if he wanted to pitch next year to some degree and it wasn't a sure thing for it to continue in St. Louis, he would step down and call it. That's the class in Wainwright, which along with his charity work in town, speaks to the first-class human that the pitcher is and has been for a decade and a half.

Wainwright is a Hall of Fame person, and a very good pitcher. He'll retire with honors and accolades, becoming a fine coach and St. Louis area legend.

Look at that. 2020 has given us many poor and distasteful things, but it's giving me a glimpse into the future for some wild reason. I am taking advantage of the very temporary superpower to talk about a guy who will start and finish his career in one town, pitching for one team.

For Adam Wainwright and the Cardinals, the future is still looking bright. Sounds Hall of Fame enough to me.

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Opinion | Is Adam Wainwright a Hall of Famer? - KSDK.com

HONG KONG, CHINA - Media OutReach - 22 July 2020 - Morepeople are living into old age than ever before. In 2018 The World HealthOrganization predicted that by 2020 there would be more people aged over 60years than there are children under 5 years. This prediction is on track to becorrect,and numbers in the older cohort continue to rise. This hascreated challenges in providing health and social services for burgeoning olderpopulations and governments across the globe have been slow to react.Priorities are now shifting from solely addressing the health of older people,to how societies can maximise this opportunity and provide effective, inclusiveenvironments in which to age.

This report from The Economist Intelligence Unit describesfindings from the "Scaling Healthy ageing, Inclusiveenvironments and Financial security Today" (SHIFT) Index", a benchmarking analysis around ageingsocieties, supported by Amgen. The SHIFTIndex benchmarks against a set of national-level leading practices increating an enabling environment supportive of longevity and healthy ageing forsocieties in the 19 countries comprising the Group of Twenty (G20). The SHIFT Index captures the multifactorialvariables that impact ageing across three domains: adaptive health and socialcare systems; accessible economic opportunity; and inclusive social structuresand institutions.

The research found that no G20 country isfully prepared to support healthy, financially secure, socially-connected olderpeople. The US, Australia, Canada and South Korea ranked highest in our indexwith scores in the 70s out of 100 (see table below). Broadly, those countrieswith a higher proportion of people aged over 50--including the three highest ranking countries plus South Korea,Germany, France and Japan--are implementing moreleading practices to enable inclusive environments. Wealthy countries may findit easier to respond, but wealth is not a prerequisite for providing supportiveenvironments. The best scoring health systems tend to be high-income countries,but upper-middle income Brazil, and lower-middle income Indonesia are alsomaking strides to improve health systems.

As a whole, the G20 countries perform bestin providing adaptive healthcare systems and worst in providing inclusivesocial structures and institutions, indicating that countries still have workto do to shift the focus towards building more welcoming societies for olderadults as they age. Countries also have room to improve in providing moreaccessible economic opportunities to older workers.

Despite clear progress made, governmentshave more work to do to make sure their health systems are adaptive to theneeds of older adults as they age, while also fostering inclusion and ensuringindividual economic security. A keybarrier to addressing this is lack of robust age-disaggregated data collectionby governments in areas such as dedicated health professionals, the extent ofisolation and loneliness as well as mental health.

The SHIFTIndex reveals several priority areas that may form the basis of policyresponses to develop more accessible and inclusive societies for older people:

Jesse Quigley Jones, managing editor at TheEconomist Intelligence Unit and editor of the report, said, "The challengesthat ageing populations present for economies and health systems have long-beenunderstood, yet provision of inclusive, supportive environments for olderpeople has not been a high-profile policy priority. Although wealth has emergedas a theme in the Index as a contributing factor towards healthy ageingindicators, it is not necessarily a prerequisite for providing supportiveenvironments. Lower-income nations can take low-cost measures that improveageing societies, such as enacting inclusive work environment policies andfostering inclusive and enabling social environments.

With older people particularly vulnerableto the health and societal impact of the covid-19 pandemic, it is moreimportant than ever for older people to lead healthy, independent lives for aslong as possible and avoid the need for institutional care. While our data werecollected pre-pandemic, the priorities identified in the report are now throwninto sharper light and may serve as a wakeup call for governments across theglobe for providing adaptable, accessible and inclusive environments in whichpopulations can age."

Forthe whitepaper, infographic and index workbook, please visitageingshift.economist.com

Shifting demographics: a global study oninclusive ageing is a report by The EconomistIntelligence Unit, supported by Amgen. It considers policy efforts to addressactive and inclusive ageing in 19 countries based on a first-of-its-kind indexthat benchmarks each country's performance across accessible and affordablehealthcare, social connectivity among older adults, and finance security practicesand policies.

The "Scaling Healthy ageing, Inclusiveenvironments and Financial security Today" (SHIFT) Index and the relatedresearch programme whose findings form the basis for this report were informedby extensive research and guided by an international panel of experts fromacross academia, government, non-governmental organizations (NGOs) andinternational financial institutions.

The following 19 countries (comprisingthe G20 and excluding the EU) are included in this analysis: Argentina, Australia,Brazil, Canada, China, France, Germany, India, Indonesia, Italy, Japan, Mexico,Russia, Saudi Arabia, South Africa, South Korea, Turkey, the UK and the US.These were selected to broadly represent the world: covering roughly 65% of thepopulation and 75% of global GDP.

The EconomistIntelligence Unit is the world leader in global business intelligence. It isthe business-to-business arm of The Economist Group, which publishes TheEconomist newspaper. The Economist Intelligence Unit helps executives makebetter decisions by providing timely, reliable and impartial analysis onworldwide market trends and business strategies.

More informationcan be found at http://www.eiu.com or http://www.twitter.com/theeiu

Amgen is committedto unlocking the potential of biology for patients suffering from seriousillnesses, by discovering, developing, manufacturing and delivering innovativehuman therapeutics. This approach begins by using tools like advanced humangenetics to unravel the complexities of disease and understand the fundamentalsof human biology.

Amgen focuses onareas of high unmet medical need, and leverages its expertise to strive forsolutions that improve health outcomes and dramatically improve people's lives.A biotechnology pioneer since 1980, Amgen has grown to be one of the world'sleading independent biotechnology companies, has reached millions of patientsaround the world, and is developing a pipeline of medicines with breakawaypotential.

For moreinformation, visit http://www.amgen.com or http://www.twitter.com/amgen.

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The US, Australia and Canada lead, but no G20 country is fully prepared for the needs of ageing populations, according to new research from the...

Bill Gates famously warned in 2015 that the next big threat to humanity was a pandemic that we are not ready for.But did he predict that the Covid-19 virus would take top spot as the greatest disruptor this century- ahead of technology and the aging population?

Living with the pandemic has become the new normal, and made the world realize that health is our greatest asset and cornerstone of prosperity.

But who could have imagined, even six months ago, that governments around the world would inject over $9 trillion to save the global economy?These bailouts are ushering in a new era of state intervention in our lives and the public is on side.

Respondents to the Edelman Trust Barometer conducted in April want government out front in all areas of the pandemic response: to provide economic relief (86%), to get the country back to normal (79%), to contain Covid-19 (73%), and to inform the public (72%). The barometer also shows the pandemic has cast a spotlight on systemic inequity- with 67% believing that those with less education, less money and fewer resources are bearing a disproportionate burden of the suffering.

There is no doubt that the fracture lines of society have been horribly exposed, with those in the poorest health and living in deprived communities hardest hit. For some countries, the immediate threat has receded at least for now- whereas for others, like in the U.S.A. and South America, worse is yet to come.Most experts agree that we will be living with the pandemic for some time, even if a vaccine becomes available later this year.

While governments and healthcare systems wrestle with the immediate crisis, businesses have had to act quickly too.

Almost overnight, major companies shifted most of their employees home to work remotely, and patients turned to chatbots, apps and video calls rather than travel to the clinic to see their doctors. The pandemic has shown how quickly we can make radical changes to our lifestyles, abandoning habits and practices long seen as essential- and leaving empty trains and desolate city centers in the process. These shifts may not be temporary either- indeed may become permanent reminders of dramatic behavioral and cultural shifts underway.

Rather perversely, many positives are unfolding that are powerful and compelling.For one thing, leaders have a once-in-a-lifetime opportunity to reshape how societies can provide healthier, better, greener, and more equitable outcomes for all, an opportunity that the World Economic Forum has hailed as the Great Reset.The cornerstone of this Reset is a new stakeholder capitalism; indeed, in May 2020, aFortune surveyfound that roughly half of chief executive officers believe the crisis will accelerate their move towards this more inclusive version of capitalism.

And it will be the innovative, ethical companies responding nimbly and creatively in addressing the urgent societal challenges facing us who will benefit most- as proponents argue that social returns will bring commercial returns too.Companies like Sainsburys prioritizing deliveries to the most vulnerable and Co-Op usingits community wellbeing index to triage support during the crisis; LMVH, the company behind Dior and Louis Vuitton, that converted their plants to make hand sanitizer for hospitals at no cost; and BrewDog, the UK brewer, that launched its own sanitizer for the NHS, with Anheuser-Busch,Pernod-Ricard, Bacardi, Tito and smaller distilleries doing the same in the U.S.A.In Asia, financial market operatorHKEX organized an emergency relief donation of HK$10 million to local communities and NGOs.

Beyond the immediate crisis, there is still a lot for business to do. Despite the many great examples of purpose-driven businesses doing great things, half of the people recently surveyed by Edelman believe business is doing poorly, mediocre or completely failing at putting people before profits. Fortunately, the changes we have already seen in response to Covid-19 prove that a reset of our economic and social foundations is possible, and is our best chance to instigate stakeholder capitalism.

The time is now to make this a permanent fixture of the new normal.

In February, the U.K.s All-Party Parliamentary Group (APPG) for Longevity published The Health of The Nation: A Strategy for Healthier Longer Livesto deliver 5 extra years of healthy life expectancywhile minimizing heath inequalities -a government ambition enshrined in the current government manifesto.Published just before the impact of the pandemic took old, its recommendations are no less important, and indeed have become more pressing and resonant.

The continued work of the APPG in seeking ways to improve the health of the nation and reduce health inequalities is so important to us all now more than ever," says Yvonne Sonsino, Global Co-Leader, Next Gen at Mercer.

One of the recommendations, a Business Coalition for a Healthier Nation, is now in the process of being set up, with leaders from insurance, banking and other sectors, and with the support of central government.The Coalition recognizes that shaping the recovery and charting a new course for growth ahead will require greater collaboration between businesses, academia, government institutions and citizens themselves.

It places preventative health firmly at the center to build up health and economic resilience. Indeed, arguably the even bigger crisis looming is the chronic disease epidemic- delays in cancer diagnosis andbacklogs of cases have all increased with people fearful of seeing doctors and going to hospitals, only adding to the significant burden that existed before the pandemic.The recent OpenSafely study showed that people with obesity, diabetes, coronary heart disease and hypertension were much more likely to die from Covid-19, all mostly preventable diseases linked to social inequalities too.

A recent McKinsey report estimates that the cost of ill health was about 15% of global real GDP in 2017, and that the Covid-19 pandemic and its repercussions will reduce global GDP by 3 to 8 % in 2020, concluding: Long-term prevention and health promotion, which encompasses more than 70% of the benefits we identified, cannot simply be left to healthcare providers or healthcare systems. It is quite literally everybodys business.

In response, the Business Coalition is proposing, amongst other things, to develop a risk management framework for health and corresponding index to measure business contributions to health.It recognizes the link between human health and planetary heath too. As Colin Matthews, Chairman of EDF Energy, said: Therell be no healthy economy without a healthy population and a healthy planet.

Indeed, health is where the climate change agenda was 10 years ago.Businesses involved in the Coalition argue we should be guiding investment and innovation decisions by Environmental, Social and Governance (ESG) mandates like we do for climate change, applying them to healthy life expectancy and societal health; institutional investors should be thinking about the stranded asset risk of things that cause health risks, and businesses should report on health risks like they are doing increasingly on climate issues. Crucially, Coalition leaders say we need to prioritize capital for large-scale, long-term, sustainable investment in preventative health.

Andy Briggs, CEO of Phoenix Group, Co-Chair of the U.K. Longevity Council, and founding member of the Coalition, says: We need to show how to make sustainability absolutely core in all businesses.

See more here:
The Greatest Disruptor Of The 21st Century Makes Health Our Most Precious Asset - Forbes

COVID-19 Updates We will be covering the overall impact of COVID -19 on the market value, market share & growth of the market and how the major players in the particular market are adapting these changes.

MarketResearchBazaar has added latest research report on Global Anti-Senescence Therapy Market, this report helps to analyze top manufacturers, regions, revenue, price, and also covers Industry sales channel, distributors, traders, dealers, Research Findings and Conclusion, appendix and data source.

The global Anti-Senescence Therapy market was valued at $XX million in 2019, and MAResearch analysts predict the global market size will reach $XX million by the end of 2026, growing at a CAGR of XX% between 2019 and 2026.

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In this report, the study analysis was given on a worldwide scale, for instance, present and traditional Anti-Senescence Therapygrowth analysis, competitive analysis, and also the growth prospects of the central regions. The report gives an exhaustive investigation of this market at country &, regional levels, and provides an analysis of the industry trends in each of the sub-segments, from sales, revenue and consumption. A quantitative and qualitative analysis of the main players in related regions is introduced, from the perspective of sales, revenue and price.

According to Research, the global Anti-Senescence Therapy market was valued at USD xxx million in 2019, and it is expected to reach a value of USD xxx million by 2026, at a CAGR of xx% over the forecast period 2021-2026. Correspondingly, the forecast analysis of Anti-Senescence Therapy industry comprises of Asia, North America, South America, Middle East and Africa, Europe, with the sales and revenue data in each of the sub-segments.

At the upcoming section, this report discusses industrial policy, economic environment, in addition to the fabrication processes and cost structures of the industry. And this report encompasses the fundamental dynamics of the market which include drivers, opportunities, and challenges faced by the industry. Additionally, this report showed a keen market study of the main consumers, raw material manufacturers and distributors, etc.

Geographically, this report is segmented into several key Regions, with production, consumption, revenue (M USD), market share and growth rate of Anti-Senescence Therapy in these regions, from 2014 to 2026 (forecast), covering

Asia-Pacific (China, Japan, Korea, India and Southeast Asia)

North America (United States, Canada and Mexico)

Europe (Germany, France, UK, Russia and Italy)

South America (Brazil, Argentina, Columbia)

Middle East and Africa (Saudi Arabia, UAE, Egypt, Nigeria and South Africa)

Global Anti-Senescence Therapy market competition by top manufacturers, with production, price, revenue (value) and market share for each manufacturer, the top players including

Unity Biotechnology

Siwa Therapeutics

Calico LLC

AgeX Therapeutics

Numeric Biotech

Human Longevity

Cleara Biotech

OisinBiotechnologies

Recursion Pharmaceuticals

Sierra Sciences

Proteostasis Therapeutics

Senolytic Therapeutics

Allergan

On the basis of product, this report displays the production, revenue, price, market share and growth rate of each type, primarily split into

Gene Therapy

Immunotherapy

Others

On the basis on the end users/applications, this report focuses on the status and outlook for major applications/end users, consumption (sales), market share and growth rate of Anti-Senescence Therapy for each application, including

Cardiovascular Diseases

Neural Degenerative Diseases

Ophthalmology Disorders

Others

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Major Point of TOC:

Chapter One: Anti-Senescence Therapy Market Overview

Chapter Two: Anti-Senescence Therapy Market Segment Analysis by Player

Chapter Three: Anti-Senescence Therapy Market Segment Analysis by Type

Chapter Four: Anti-Senescence Therapy Market Segment Analysis by Application

Chapter Five: Anti-Senescence Therapy Market Segment Analysis by Sales Channel

Chapter Six: Anti-Senescence Therapy Market Segment Analysis by Region

Chapter Seven: Profile of Leading Anti-Senescence Therapy Players

Chapter Eight: Upstream and Downstream Analysis of Anti-Senescence Therapy

Chapter Nine: Development Trend of Anti-Senescence Therapy (2020-2029)

Chapter Ten: Appendix

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Global Anti-Senescence Therapy Market 2020 Business Strategies, Product Sales and Growth Rate, Assessment to 2025 - Cole of Duty

The report is a comprehensive research study of the Global Genomics Market inclusive of the latest trends, growth factors, developments, opportunities, and competitive landscape. The research study includes an in-depth analysis of the market using advanced research methodologies such as SWOT analysis and Porters Five Forces analysis. The report is formulated from data gathered from primary and secondary research examined and validated by industry experts. The report provides an overview of market leaders, segmented by type, application, region, and technological advancements.

Furthermore, the report provides a comprehensive analysis of the impact of the COVID-19 crisis on the market. It offers a detailed insight into the impact of COVID-19 on the industry at a regional level and industry level. The report also covers the developments and regulatory policies related to COVID-19. It further analyzes the current and future impact of COVID-19 on the global market and provides insights into the situation post-COVID-19.

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The report provides assistance to the clients by providing insightful data about limitations and opportunities to enable a decision-making process. The report provides an in-depth insight into the growth factors, recent technological developments, and comprehensive profiling of the key market players. The report titled Global Genomics Market Report Forecast to 2027 provides essential information about the techniques of the key players in the industry, their technological advancements, and assists readers in making profitable business decisions.

The key players studied in the report are 23andMe, Oxford Nanopore Technologies, Precise.ly, 54Gene, Guardant Health, Allogene Therapeutics, Oxford Nanopore Technologies, Pacific Biosciences, CardioDx, Helix, Human Longevity, Foundation Medicine, Freenome, and Veritas Genetics.

The report further segments the market based on product type and end-use applications. It provides insightful data and strategic recommendations in order to gain a better understanding of the global scenario.

Product types in the market:

key applicationsin the market:

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Market Drivers and Constraints:

The global Genomics market research report provides a brief overview inclusive of the competitive landscape and key developments, policies, manufacturing costs, and processes. The report also provides an analysis of import/export, production and consumption ratio, supply and demand, cost, price, estimated revenue, and gross margins.

The report further discusses in detail the driving factors influencing the growth of the market currently and in the coming years. It also sheds light on restraints that are expected to hamper the growth of the industry.

Following significant market factors are discussed in the report:

To know more about the report @ https://www.reportsanddata.com/report-detail/genomics-market

The report studies the main players of the market along with their strategies, business expansion plans, and competitive prospects. The report also studies micro and macro-economic factors, government policies, consumer dynamics, and manufacturing aspects. The report provides a detailed COVID-19 impact analysis.

David is an Experience Business writer who regularly contributes to the blog, He specializes in manufacturing news

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Genomics Market Provides in-depth analysis of the Genomics Industry, with current trends and future estimations to elucidate the investment pockets By...

THURSDAY, July 16, 2020 (HealthDay News) -- Bats have been blamed as a possible source of the new coronavirus pandemic ravaging the globe. But they might also point to possible ways out of it.

Scientists say the winged mammals' immune systems may offer clues on how to fight the new coronavirus and other dangerous viruses in humans.

"Humans have two possible strategies if we want to prevent inflammation, live longer and avoid the deadly effects of diseases like COVID-19," explained study lead author Vera Gorbunova, a professor of biology at the University of Rochester in New York. "One would be to not be exposed to any viruses, but that's not practical. The second would be to regulate our immune system more like a bat."

Many deadly viruses that affect people are believed to have originated in bats, including rabies, Ebola and SARS-CoV-2, the strain that causes COVID-19. But bats have evolved a secret weapon: They're better able to tolerate viruses than humans and other mammals.

"We've been interested in longevity and disease resistance in bats for a while, but we didn't have the time to sit and think about it," Gorbunova said in a university news release.

"Being in quarantine gave us time to discuss this, and we realized there may be a very strong connection between bats' resistance to infectious diseases and their longevity. We also realized that bats can provide clues to human therapies used to fight diseases," she explained.

Typically, a species' lifespan is associated with its body size. The smaller a species, the shorter its lifespan. But many bat species have lifespans of 30 to 40 years, which is impressive for their size, the authors noted in a review article published recently in Cell Metabolism.

Bats' longevity and tolerance to viruses may be due to their ability to control inflammation, which is involved in both aging and disease. Viruses, including COVID-19, can trigger inflammation.

With COVID-19, this inflammatory response goes "haywire," Gorbunova said. In fact, in many cases it is the inflammatory response that kills the patient, more so than the virus itself.

"The human immune system works like that: Once we get infected, our body sounds an alarm and we develop a fever and inflammation. The goal is to kill the virus and fight infection, but it can also be a detrimental response as our bodies overreact to the threat," Gorbunova said.

In contrast, bats' immune systems control viruses without mounting a strong inflammatory response.

There are several possible reasons why bats evolved to fight viruses and live long lives. Flight may be one of them, the researchers noted.

Bats are the only mammals that can fly, which required them to adapt to rapid increases in body temperature, sudden surges in metabolism and molecular damage. These adaptations may also assist in disease resistance, the study authors suggested.

Another factor is that many species of bats live in large, dense colonies, and hang close together on cave ceilings or in trees. Those conditions are ideal for transmitting viruses and other pathogens.

According to Andrei Seluanov, a biology professor at the University of Rochester, "Bats are constantly exposed to viruses. They are always flying out and bringing back something new to the cave or nest, and they transfer the virus because they live in such close proximity to each other."

This means that bats' immune systems are continuously adapting to deal with new viruses. Studying bats' immune systems could lead to new ways to fight aging and diseases in humans, the researchers said.

More information

The U.S. Centers for Disease Control and Prevention has more on COVID-19.

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Coronavirus May Have Come From Bats; Could They Also Hold Clues to Treatments? - HealthDay News

Amid speculations over Covid-19 vaccines, a top official from the Indian Medical Association (IMA) has reportedly claimed that a vaccine would reach usable stage only after 2020.

A usable vaccine to cure COVID-19 and bringing the same to good use would go beyond 2020, a news agency quoted an Dr V K Monga, IMA Board of Hospitals Chairman as saying.

He said that developing a vaccine for viral infections is a longer process as firstly, these infections have shorter immunity and secondly, viruses mutate faster, so this makes developers clueless as to which mutation is there in which part of the country.

Dr Monga further said for developing a vaccine there are multiple stages and steps.

Developing a vaccine is not a political decision, it involves a lot of steps and procedures, he said.

First, we isolate the virus then you develop an antidote to that, followed by animal testing and then on human volunteers. Secondly, you see the efficacy, toxicity and then its longevity as to how long it sustains, Monga said.

He said since, the viral infections have shorter immunity; a vaccine with a longer effect is to be seen, secondly, we have to see that it has no side effect and thirdly, viruses mutate faster and hence, it has to be seen that the vaccine is effective on most of the mutants as we dont know which mutated virus is present in which part of the country.

Speaking about the rise in the recovery rate, Dr Monga said that in this particular disease, approximately 80 per cent of the people are recovering on their own.

These patients will automatically recover. Home isolation is a good thing, he said.

Monga said people using masks and adhering to social distancing norms is also increasing recovery.

However, he clarified that plasma therapy, which is being seen as the only solution to COVID-19 in place of the absence of the vaccine, cant minimise the need of a vaccine.

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Covid-19 vaccine will reach usable stage after 2020: Expert - Northeast Now

John Lewis served in Congress since 1987, representing Georgia in the House of Representatives. But his constituents were far from all the longtime legislator, who died on Friday at age 80, represented.

Lewis was a witness to, participant in and survivor of some of the most pivotal moments of the American civil rights movement: he gave a speech at the 1963 March on Washington; he marched across the Edmund Pettus Bridge in Selma, Ala., in 1965; he took part in more recent acts of resistance. In a movement in which so many great lights were extinguished early, his longevity left him to serve as a de facto spokesman for what he saw.

But its not by chance that Lewis name is tied so closely to the nations still-visceral memories of those moments. Throughout his life, the Congressman spoke often about his purposeful quest to tell and retell the story of what he had been through, so that nobody could forget. He turned his experiences into bestselling books and share-worthy speeches and even a catchphrase and he did so with intention.

In 2017, Lewis spoke to TIME for the magazines 10 Questions feature. In this previously unpublished excerpt from the conversation, Lewis explained why he kept telling his story, even though it wasnt easy for him:

Youve talked about the importance of telling the story [of the civil rights movement] over and over again, and how it affects the people who hear it. But how does telling that story again and again affect you?

Yes, when I tell the story, and I tell it over and over again, even for hundreds and thousands of students, to little children and adults who come to the office or when Im out on the road speaking, it affects me and sometimes it brings me to tears. But I think its important to tell it. Maybe it will help educate or inspire other people so they too can do something, they too can make a contribution.

I went up to Rochester, N.Y., back in October, with a colleague of mine, Louise Slaughter, who represents Rochester. [Slaughter died in March of 2018.] And I went to a church that Frederick Douglass had attended, an African American Methodist church, and I went to a house called the Motherhouse. Two of the nuns that took care of us at the hospital in Selma when we were beaten on March 7, 1965, they retired there. These two nuns are feeble, up in age, but they recognized me and they called me John and I called them sisters. There were many other nuns sitting around and they started crying and I cried with them and hugged them, and they showed me this stained glass that was taken from the chapel of the hospital in Selma, which is now closed, and theyd brought it to Rochester. And we stood there and did a song and a hymn.

Its uplifting and its powerful to me to tell the story and to respond to people asking questions. It makes us all stronger and more determined.

Civil Rights leaders, including future Congressman John Lewis (third left) and Gloria Richardson (third right), chair of the Cambridge Non-Violent Action Committee, link hands as they march in protest of a scheduled speech by the pro-segregationist Alabama governor, George Wallace in Cambridge, Md., in May 1964.

Francis MillerThe LIFE Picture Collection via Getty Images

Ive heard that one of the catalysts that inspired you to run for office was the run of terrible things that happened at the end of the 1960s, the assassinations of Robert Kennedy and Martin Luther King Jr. Whats the key to responding to terrible things by taking action rather than just collapsing?

You have to pull up on the best in the human spirit. You just say Im not going to be down. You have what I call an executive session with yourself. You could say, Listen self, listen John Lewis, youre just not going to get lost in a sea of despair. Youre not going to be down. Youre going to get up.

The assassinations of Dr. Martin Luther King Jr. and Robert Kennedy was the saddest time in my life. I admired both Martin Luther King Jr. and Robert Kennedy. I admired those two men. Martin Luther King Jr. had taught me how to stand up, to speak up and speak out, and how to get involved. When I first met him, he called me the Boy from Troy, and up until the time of his death, he still referred to me as the Boy from Troy, because I grew up outside of Troy, Alabama. And I met Robert Kennedy for the first time in 1963, when I was 23 years old, before the March on Washington. And he was so inspiring, so uplifting. In my Washington office, I have a picture with him when he was Attorney General, from a campaign poster from 1968. These two young leaders, I thought, represented the very best of America. And when Dr. King was assassinated, I was with Bobby Kennedy when we heard. And as a matter of fact, it was Bobby Kennedy that announced at this campaign rally at Indianapolis, Indiana, to the crowd. As I was working on this campaign, trying to get people to come out to the rally, he said, we have some bad news tonight, Martin Luther King Jr. was assassinated in Memphis, Tennessee. I heard that hed been shot but we didnt know his condition.

And I really felt when the two of them died that something died in America. Something died in all of us. And sometimes we never recover from situations like these. I became convinced in myself that I had to do something, I had to pick up where Dr. King left off and Bobby Kennedy left off.

One of the civil rights-era experiences that Lewis often recounted, as he told what he had been through, was the experience of hearing Martin Luther King Jr. speak on the radio when Lewis was a teenager. Lewis felt, he would say, that King was speaking directly to him, telling him to get involved and that the spirit of history was moving through him, too. The spirit of history told him that the moment was right to stand up, and that the time had come to take his place in the story of the world.

Now, as America remembers a civil rights leader who protected and advanced that legacy in the decades after Kings assassination, it seems safe to say that the spirit was right.

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Write to Lily Rothman at lily.rothman@time.com.

Original post:
Why John Lewis Kept Telling the Story of Civil Rights, Even Though It Hurt - TIME

Dr Villoo Morawala-Patell, Founder, Avesthagenand her team has been researching on genetic basis of disease risk associated with longevity and the endogamy prevalent within various communities. Theirpurpose is to deliver population-specific qualified biomarker targets to achieve the holy grail of genomics predictive, preventive, and personalised medicines. In an interview withRaelene Kambli, Dr Patell reveals more on their research and its application in the development and validation of cancer biomarker. She also delved into explaining theneed for a cross-disciplinary integration of scientific and clinical expertise for research especially in the field of cancer

What according to you is the most promising area of your current research?

The most promising area of our current work in terms of innovation is the significant and prolific outcomes from the Avestagenome Project for cancers, neurodegenerative conditions, and rare diseases. Our recent work on the genomics of the Zoroastrian-Parsis converges, ancient history, human migration, endogamous population genetics, social behaviour and customs that express in genetic signatures of wellness and health.

Specifically, we present a population genetics study wherein we assembled the first,de novoZoroastrian-Parsi Mitochondrial Reference Genome from one individual and the first Zoroastrian-Parsi Mitochondrial Consensus Genome derived from the assembly of 100 complete mitochondrial genomes of the dwindling, endogamous, non-smoking Zoroastrian-Parsi community of India. Phylogenetic analysis of the 100 Parsi mitochondrial genome sequences, showed a largely Persian origin for the Parsi community of India.Disease association mapping showed that the majority of the mitochondrial variants to be linked longevity and its associated conditions revealing the genetic basis for many of the heritable diseases in the community like cancer, neurodegenerative diseases like Parkinsons, Alzheimers and many rare genetic conditions.Our study is a first in tackling the genetic basis of disease risk associated with longevity and the endogamy prevalent within the community. The outcome of this study has an impact on all populations

So, your paper suggests that Zoroastrian-Parsi genes may help scientists characterise biomarkers predictive of diseases caused by tobacco use, such as lung, head and neck, and oesophagus cancers. Can you elaborate on the same?

We found 420 mitochondrial variants in our analysis of the 100 Zoroastrian-Parsi mitochondrial genomes. The detailed analysis brought to light the absence in the Zoroastrian-Parsi samples variants in mitochondrial genes like ND5, ND6 and tRNA that are shown to be associated with lung cancer and non-small cell lung cancer in other non-Parsi populations. Many of these reported genes have been associated with smoking-induced lung cancer and other smoking-induced cancers. Our study thus serves as a biological validation ofa well-known cultural phenomenon, reflecting the practice of abstinence from smoking in Zoroastrian-Parsis whose origins date back a millennium.

How helpful is this information for your research and what does it imply?

Our study is unique and provides a road map for understanding the genetic factors that underlie ageing and longevity associated diseases. A vast majority of the 420 mitochondrial variants are associated with longevity and conditions like Parkinsons disease, Alzheimers disease as well as breast, colon, prostate, ovarian cancer, infertility disorders like asthenozoospermia and rare neuronal diseases associated with mitochondrial dysfunction. Indeed, epidemiological studies of the community do show a preponderance of these diseases and a strong bias for the inheritance of these genetic disease variants owing to the practice of endogamy within the community. Our current study will complement our research goals as we accelerate our whole-genome analysis of the Parsi community to identify from the control population, alongside other comparative population subjects. The purpose is to deliver population-specific qualified biomarker targets to achieve the holy grail of genomics predictive, preventive, and personalised medicines.

What are the key findings of this study?

Our insights from the assembly of the archetypical Zoroastrian-Parsi mitochondrial genome extend from human migration to the genetic basis of disease prevalence. Our phylogenetic analysis showsalargely Persian origin for the Parsi community and revealed the presence of seven major haplogroups and 25 sub-haplogroups in our study group.We believethe strict endogamy practised by the Zoroastrian-Parsi community, has meant that their maternally inherited mitochondrial genome has remained largely unchanged from that of their ancestors in Old Persia. We also see the prevalence of genetic variants, specifically 217 unique variants linked to longevity and 41 longevity associated conditions like cancers, neurodegenerative disease, and rare diseases. We did not find any mitochondrial variants previously reported for lung cancer in our study and found an extremely low frequency of mutational signatures linked to tobacco carcinogens, reflective of the strong disapproval of smoking in the Zoroastrian religion. Another exciting outcome of our study is the discovery of 12 unique mitochondrial gene variants distributed across 27 subjects that have not been reported in public databases that index mitochondrial variants discovered thus far in other studies. We are currently in the process of investigating their function in the context of diseases.

So, you mean the gene expression picked from this study can be implemented to tailor adjuvant therapy among common cancers?

Mutations in mitochondrial DNA (mtDNA) can cause a range of incurable and life-limiting metabolic diseases in humans. Our current study has identified crucial disease associated with genetic variants in the mitochondrial genomes of the Zoroastrian-Parsi community. Our study is a necessary first step to tailor therapeutic strategies that involve targeting validated mitochondrial biomarkers involved in diseases. Given the advent of technologies that enable precise genome editing like CRISPR, we believe our study will benchmark crucial mitochondrial disease-associated variants, classify its prevalence and risk outcomes to complement and tailor therapies that can correct genetic mutations, thus improving patient outcomes in the case of complex genetic diseases like cancers.

How much of your study will pave the path to an era of personalised medicine?

It may be fortuitous that our current study is published on the heels of another study published describing important milestone in editing mitochondrial genomes. Mok, BY et al (Nature, July 2020) has demonstrated the ability to enable precise editing of mtDNA. Our study and its future outcomes will provide a database of mitochondrial variants associated with various conditions to further enhance the possibility of precisely editing the inheritable mutations in mitochondrial genomes, moving the needle towards personalised medicines.

Are there any indicators that may raise caution?

Indeed, any disease associations in a dwindling population is a cause for concern. We show an increased association of variants with conditions like Parkinsons disease, prostate, colon and ovarian cancers, rare diseases resulting in an inherited visual disability like LHON, hearing disability, muscular dystrophy like diseases and infertility. Understanding the molecular mechanisms of these variants resulting in clinical manifestations is extremely important in framing healthcare policies that include precise diagnostic platforms for early disease diagnosis and therapy, steps necessary to arrest the declining numbers in communities like the Zoroastrian-Parsis and other close-knit communities across the world.

What are your predictions for the next five years in cancer biomarker development and validation?

In the next five years, understanding of most cancers would be linked to population genetics and would be individualised into specific groups for treatment. Specific targeted drugs linked to a subset of biomarkers found in each individual patient leading to precision individualised therapies would be the order of the day.

Do you think that there is a need for a cross-disciplinary integration of scientific and clinical expertise for research especially in the field of cancer?

Cross-disciplinary research, especially in cancer, is increasingly relevant and important to reducing that gap in what is identified as best practice and what happens in clinical care. Narrowing this knowledgepractice gap continues to be a slow, complex, and poorly understood process, particularly for research that encompasses the notion of transdisciplinarity, as in the case of complex diseases like cancers. The assimilation of diverse perspectives, research approaches, and types of knowledge is important in helping research teams tackle real-world patient care issues, create more practice-based evidence, and translate the results to clinical and community care settings.

[emailprotected]

[emailprotected]

Continue reading here:
How genetic studies will become the holy grail to find cancer biomarkers in future - Express Healthcare

The Internet of Things refers to smart devices that are capable of transferring information on a network. Although Kevin Ashton, the acclaimed co-founder, and director of the MIT Auto ID Centre, is credited with inventing the term, it wasnt until 2008 2009 that the concept became widely known.

As internet-enabled devices multiplied in production and installations, there were 12.5 billion internet-connected devices in 2010, so did the general awareness associated with IoT. Fast forward to 2020, there are about 31 billion IoT devices amongst us and a considerably few questions around what is IoT.

As the IoT technology proliferates the marketplace, so does its form and utilities being realized by people in general. And why not? Combined with robotics and AI, the IoT technology hammers out human-dependencies from supply chains and reduces the cost to businesses. Nowhere is this more applicable than perhaps the food industry.

Beginning from the very farm that your food grows in, to the warehouses that store it and the retailers that distribute it, the food service industry has stepped in a new age of remote monitoring, sensing, and action that will have profound, and mostly positive, implications for its supply chain players. Let us find out how.

From disease control measures to cattle and field monitoring systems, IoT is transforming the industry of agriculture by putting the power back where it belongs. Into the farmerss hands. Major sectors where this tech has found a solid footing are indoor farming, livestock management, and aquaculture among others. But how is IoT overcoming challenges and breaking new ground in farming?

Robots have come a long way since the third industrial revolution, abetted by the development of the internet. Although far from changing the face of the F&B industry, agricultural robots aka agribots could offer a circumventing solution to the problem of labor shortages. Unmanned Aerial Vehicles (UAVs) can be deployed to detect and exterminate weeds from the field. They could save farmers time, human resources, and spray volumes by acting precisely as per the demand. This saving translates into a healthy soil that has a lesser amount of pesticides/weedicides to absorb and more positive bacteria to preserve.

Machine learning, GPS, and the internet of things are making manned machine navigation a thing of the past. Farmers can remotely control their tractors, rotavators, and a host of agricultural machinery with a smartphone. As the code memorizes rough patches, it learns to alter gears and smoothen navigation to both protect the crops and the equipment.

Crop harvesting often turns out to be the plight of farmers often due to untimely harvests. Factors influencing such events could be the weather, untrained personnel, or other poor farm management. Harvesting robots could be trained with the wealth of information that we now possess to pick the right fruit at the right time. With the Internet of Things technology, farmers could grow high-value crops at scale than hedge their bets with varieties supported by minimum support prices.

Another way by which the food industry is scaling its appetite for the Internet of Things is by installing on-field sensors. By design, sensors are engineered to detect discrepancies in weather conditions, crop nutrition, soil pH, and more. Such a smartly coded crop monitoring system offers advance intel to farmers and warns them to prepare for exigencies.

Drones are yet another example of IoT in the food industry. The self-guiding technology makes use of GPS, image processing, infrared cameras, and ground control systems. New generation farmers are leveraging Drones-as-a-Service (DaaS) to predict crop yields, diagnose pest infestation, precision fertigation, and field supervision. Aerobotics is one of the few food tech startups that have made their mark in the field, literally. It combines drone scouting and multi-sensor analysis to predict crop health for longevity.

The food manufacturing industry is high on the deployment of the Industrial Internet of Things (IIoT). The two most suited application areas of IoT that have emerged so far are manufacturing and packaging. Both the SMBs and enterprise vendors have realized the value-added, multifold benefits of IoT in the F&B industry and the following sections illustrate further on it.

The use of IoT in warehouse management is known to be a recurrent top IoT trend. Inventory tracking consumes a lot of overheads and unaccounted muscle-power in the food service industry. Massive swathes of data need constant reconciliation and therefore must be accurate. Sensors act as immaculate tracking devices for warehouse inventory, the data pertaining to which is updated in the software real-time. Consequently, the stock loading times are optimized, managers maintain a magnified vigil on supply chains, due to which the storage space is fully taken advantage of.

Automated guided vehicles (AGVs) and collaborative robots can go so far in fetching deeply buried stocks in densely packed shelf lines. So if human intervention cant be uprooted it can surely be made smart and that is what vision picking glasses do. Think Google glass with a lot more information packed in it. Vision picking marries the internet of things with the food industry helping humans identify the right storage zones.

Internet-enabled microchips can be embedded in state-of-the-art food packaging that will expose the originality of the product, once scanned. QR codes are spin-offs of the same concept that evaporate doubts over the authenticity of the product. Especially in times like COVID, customers ordering food online are terrified than ever about the origins of its supply chain. As a result of which an IoT app development company like us is working seriously to offer this feature to our clients.

You never know what customers demand, at least that is what our experience as a food delivery app developer tells us. Integrating QR codes isnt enough. They come in telling us that their stock keeping units are packages with such advanced sensors that indicate not just the veracity of quality but whether the sealing has been broken or not, the source of its ingredients, yadda yadda yadda. For the uninitiated, that is yet another way the internet of things technology is transforming the industry of food.

Modern-day customers love exploring the possibilities associated with food. While sharing the supply chain credentials established trust, offering insights on how to unleash and savor lesser-known recipes takes engagement to impressive levels. As a food app development company, we recommend IoT triggers that inform viewers of add-on combinations to enjoy edible items with. Its a strategic way to augment food packaging with dynamic, ever-changing information that cannot be printed in the first place.

One of the IoT challenges a food delivery app development company like us comes across on our daily roaster is how to make products fly off the shelf without any marketing gimmicks. Turns out we can use IoT (duh!) to run flash-sales for items with low shelf life or those closing in on expiry. Buy one get two offers makes most of us drool.

While open food markets and retailers are the two major platforms for distributing farm produce to consumers, restaurants, road-side eateries, and hotels act as other outlets. Due to this reason, restaurant mobile app developers have been reshifting focus on how to drive IoT in operations. Lets see how businesses can go about their business the smart way with IoT.

For locations that regulate strict recycling legislations, reverse vending machines are a common sight. They incentivize people to deposit disposable/recyclable materials such as cans and plastic bottles by paying them a certain sum. Integrating IoT-enabled programs notifies the retail staff to empty the machine before a queue begins to form. Lesser queues translate into happy customers the lifetime effect of which can be felt in return-customers and their purchase orders.

Refrigeration or storage is a huge concern for the food manufacturing industry. At most locations, operations still depend on the same old, fractured system of human aided supervision. This discounts the fact that the human eye is prone to judgemental errors not to mention the public holidays when the storage units could be under-staffed. IoT-enabled remote monitoring systems can play a cameo in filling such ubiquitous gaps. They can prompt supervisors to action if the temperatures are fluctuating beyond the requisite limits and save precious food. Restaurant app development services like us, can create handheld smart controllers with which the user could moderate temperatures without physical presence.

Temperatures inside large supermarkets, malls, and retail chains are usually regulated by HVAC systems. But they are not intelligent and lack the ability to alter air-conditioning/central heating. An all-encompassing IoT suite could stabilize room temperature in accordance with the outside world. This would help in preserving perishable consumables that cannot bear the brunt of frequent temperature change. In addition, this energy optimization would even save millions of dollars in utility bills contributing further to cost efficiency.

Key Takeaway

The Internet of Things will continue to expand its applications territory into the foreseeable future to varied industries the foremost of which shall remain F&B. Given the well-established line of achievements Appinventiv has won in the years since inception, IoT solutions are definitely up our alley. Lets put it this way, if we dont excite you with our elevator pitch when we meet, the drinks on us. Well be waiting for your call.

Prateek Saxena

Co-founder of Appinventiv

In search for strategic sessions?.

Originally posted here:
14 Ways IoT is Impacting the Food & Agriculture Industry - Appinventiv

What Was The Inspiration Behind New Single Biting My Tongue?

Jess: We've been finishing up this album, Human,and the first part of that piece is a big hitter. It's diving into the very human aspects of emotions on this album, and the different human experiences we've been going through. And this one draws on that really peak point of wanting to confess your love for someone that's really visceral. You've tried everything to bury that feeling or keep it in, but now you're at that point where you need to let somebody know. When we're creating a song, we really build an entire world around it, so we see visuals and hear production. And Lisa started this song with DNA and then brought this song to me, and it really embodied the spirit.It's that really fatalistic spirit that become like a bit of a part of how Lisa and I write.

Jess: I don't think that we ever think about our albums comparatively to each other. Rather like a cohesive period of time that embodies whatever we were going through at the time. And although we've been writing this album over a few years, the majority of it was created in a cohesive time period.It feels like a completion of something. It feels like we had all these mini-bursts through this creation. And that whatever shift needed to happen was completed by the end of this writing phase. And each record has felt like that. But our second record and this record, most predominantly for that feeling.

Jess: I don't think it's changed, as far as the dynamic of how Lisa and I love to work. Because it comes down to being as vulnerable as possible. It always has. When we first started songwriting, we were signed as songwriters before we were signed as artists, and it was us sitting on the floor with our guitars. Just writing really personal, intimate thoughts and feelings. Then it's always stayed that. It's just that we've also cultivated new relationships with different songwriters as well. And we have our really great chemistry with people that we're working with for this album.Toby Gad's one of them, and obviously DNA, who we did In My Blood with and Biting My Tongue with. Now as well, You Ruin Me. So when you cultivate that special relationship - because Lisa and I are so comfortable working with each other - when you bring other people in, you have to really trust them as well, because we work so intimately.We're just really blessed that we've had some great relationships with people, and that we continue to be able to create in that safe space.

Lisa:It hasn't hindered anything, but it definitely encourages us to go back to our roots, which is singing and playing guitar.I think, when it all sort of happened, the majority of our live shows did get cancelled.So for us, it became more introspective, and like Jess was saying, the creation process. So rather than focusing on the part where you're on stage, really just giving a lot of energy out. It actually started to go more introspective again and go back to that space of creation, rather than presentation.

And in every aspect of life, we went through that experience of introspection and starting to grow again from the ground up. We spent more time self-reflecting and growing individually, and really thinking about where life is taking us. Getting back on the acoustic guitars and just writing to write with no real urgency or agenda - rather just to feel that moment. And if this has taught us anything, it's that you're just taking day by day and living very much in the moment; because we don't know what the future holds. And there were schedules, and timeframes and expectation all sort of got thrown out the door and we just kind of had to take it day by day; and to really figure out what...There's coping mechanisms for that.

Lisa:It was a new experience. To a certain extent, we were saying, we tend to hermit by nature when we're in creation mode.And then the other half of the year where you become a Veronica, and on your onstage, and you're giving and all that. But the other side of us is, as Jessy said before, Lisa and Jessica are in creation mode.

So I think the year - obviously, for everyone - it was a bit unexpected, but we believe adaptability is the key to longevity. And you have to adapt in these times. It's the mindset. It's the perspective you take and what you do with that time. You can somehow create some sort of positive out of it. It's a way to adapt and survive. So we're very thankful for our health, and the time to spend with family, and each other, and to create again.

Jess: It's is about slowing down a little bit and reflecting, and being able to appreciate a lot. Being grateful for the journey that we've been on, the places that we've been to in the scene. And then try to find new ways to continue to grow. And that's so important for everybody, even while with standing still, what ways can we continue to grow: as people, as a community, as humanity? We're seeing those paradigm shifts greatly in the world right now.

Jess:Yeah. I think as far as the music community, there is a lot of anxiety at the moment. And I think it's just about supporting one another. Our scenes have always had that spirit anyway.So that hasn't really changed, except that I think that it's just more prevalent than ever. And I'm hoping that, it's a test on people's emotional and mental health right now. And I think it's just really important as a community of creatives that we can all be there for one another, first and foremost.

Jess: First and foremost, our Mummy has been our greatest inspiration. From the very beginning, she introduced us to a love of music and of everything that has been of value and importance to us. She was quite the activist, and nurturing person, within the LGBT community; within animal rights. Anything that we have grown to value deeply personally for ourselves, and through The Veronica's work as well, has really been inspired by her head-strength, and her values and morals. So our mums our absolute hero and our greatest inspiration.

Read more from the original source:
The Veronicas On Their First Album In Six Years, 'Human; - Marie Claire

My youngest son, Alister, and I stood by the crate, talking in hushed voices.

Our new puppy, home with us for the first time that afternoon, had gone into the crate an hour ahead of the schedule wed been provided by the breeder.

Is she down for the night, you think? I asked my 13-year-old, like he would somehow know.

I dont know. Maybe?

It was 10 in the evening. The breeder had said she could last from 11 p.m. to 5:30 a.m. in the crate. If she went down now, would she be up at 4:30 a.m.? I wondered aloud with all the uncertainty of a first-time mom to a human baby.

Well, if she is down for the night, well have to close the crate door then, I said, edging toward a decision.

Shell wake up if we close the door, said Alister.

But we cant not close the door ...

In the end we stealthily closed the door and backed out of the room, tiptoeing our way around the creakier parts of the hardwood floor, up the stairs and out of earshot where we could further speculate on Poppys sleep schedule.

It was the start of what has been close to four weeks now of canine caregiving lessons that have opened my two teen boys eyes to some of the responsibilities of parenting better than any episode of Degrassi or a Tamagotchi toy could have done.

With interest in pet ownership skyrocketing during the pandemic while many families have more time at home to bond with and train their new animal and little else to lift their spirits households across the country are in the throes of puppy parenting.

The Toronto Humane Society had a 100 per cent adoption rate of all the animals in its shelter during April and May, compared to 93.5 per cent the same time last year. Reputable dog breeders have wait lists that stretch well into 2021 and beyond.

Everyone tells prospective puppy parents that itll be just like having a newborn in the household again. Subtracting the breastfeeding, colic and diaper changes, theyre more right than I fully appreciated.

The vigilance required for house training and keeping puppies away from choking hazards and other things that shouldnt go in their mouths is a little like being on alert with a newly mobile crawling baby or toddler. The zombie-like fatigue from night waking is definitely reminiscent of early parenting, as is the way our new responsibilities shape dialogue in our home these days.

Now were reporting to each other when our dog last had a pee or poo, how long she napped and when she last ate.

While I work, my boys negotiate off-duty time with each other to do other things, like take a shower or play a little Mario Cart.

We talk about the witching hour when Poppy gets a little hyper and hard to handle in the evening, like a cranky period with a baby. We arrange her daily play dates with the little kids next door and chart her progress on things like responding to the sit command.

And just like isolated new parents stuck at home more than ever, we notice that life is a little easier to handle when were showing off our cute new addition to people we meet on the sidewalk or friends who come by for a socially distanced backyard visit.

Although it happens that welcoming a dog to our home was in the works before COVID-19 hit, the pandemic can present an opportune time to adopt a pet, said Hannah Sotropa, public relations specialist for the Toronto Humane Society.

We really advocate that when youre looking at an adoption, you need to look at especially during this time the longevity of that decision, said Sotropa. COVID-19 will come to an end and when that time does come, looking at whether an animal still suits your lifestyle will be great in setting you, but also the animal, up for success.

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Making it work with a COVID-19 puppy comes down to being proactive as opposed to reactive, she said. That means beginning to prepare your puppy now for life in the after times and whatever sort of return to a previous routine it will bring.

If normally youre out of the house for an eight-hour shift, that means slowly working your pet up to that level of independence.

Using a crate or sanctuary room, possibly gating off an area, get your pet adjusted to being on their own in that space while the family is in other parts of the home, said Sotropa. Work your way up to departures slowly and incrementally.

The other important thing is to spread the responsibilities for your new pet among the members of your household.

Animals often get hyper attached to one person who does most of the walking, the feeding, the loving, said Sotropa.

This person we want to make less significant so that if they do have to go back to work, the animal knows, well, the other members in the house are going to provide me with what I need.

Deena Cooper, who trains and boards dogs through her business DeenaSpeaksDog.com, is already getting calls from people who are in over their heads with the responsibilities of a new puppy. Most of these pets came home during the social distancing period when puppy training classes were mostly suspended or few and far between.

Im getting lots of people wanting me to board and train their dogs; their dogs could be as young as eight weeks old, said Cooper. In some cases these new owners have fond memories of growing up with a dog but are now struggling with a puppy waking them up at night and demanding a lot of attention during the day while theyre also trying to care for their human children.

In other cases the puppies are a bit older and theyve established a lot of crazy behaviours like jumping up, nipping and barking that havent been properly addressed early.

Sotropa asks that anyone still contemplating a pandemic pet adoption think the decision through carefully.

Make no mistake that having an animal is the most rewarding, the most incredible experience; its a bond like youll have with no other, she said. However, they are a commitment and they are a commitment through thick and thin. We dont want to see animals end up back in the shelter.

This article has been changed from a previous version to correct the name of Deena Coopers business.

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Is having a new puppy like having a newborn in the house? More than I ever appreciated. - Toronto Star

After the COVID-19 rules about social distancing went into effect, I developed a morning routine of jogging through the woods near my home. During the first months, I focused on the green branches that stretch upward towards the sky, but recently I started to notice the debris of tree trunks lying on the ground. There are many such remnants, eaten by termites, rotting and ultimately dispersing into the underlying soil. A glimpse at the forest reveals a sequence of evolutionary phases in the history of trees that lived or died at different times.

The phenomenon happens in other contexts. For example, I recently completed a nine-year term as chair of the Astronomy Department at Harvard. And only now have I begun to notice the former chairs scattered around me, just like those tree trunks in the woods.

Entering a new stage of life can be humbling. We acquire a false sense of permanence from reviewing the frozen past, as if it were a statue that will never erode. But this view is shortsighted, since each moment can also be seen a new beginning, shaped by forces beyond our control and swirling on a grander scale.

Old-fashioned astronomy was also permeated by a false sense of permanence. Astronomers collected still images of the universe, creating the impression that nothing really changes under the sunor above it, either. But just like the revelation from my stroll through the woods, these snapshots showed stars and galaxies of different ages, at various evolutionary phases along their history. Computer simulations helped us patch together the full story by solving the equations of motion for matter, starting from the initial conditions imprinted on the cosmic microwave background at early cosmic times. By generating snapshots of an artificial cosmos similar to those captured by telescopes, these simulations unraveled our cosmic roots. The scientific insight that emerged is that the likely origins for our existence were quantum fluctuations in the early universe. Perhaps we should add Quantum Mechanics Day to our annual celebrations of Mothers Day and Fathers Day.

There are some missing pages in the photo album made up of our observations, however: the period known as the cosmic dawn, for example, when the first stars and galaxies turned on. These missing pages will be filled in the coming decade by the next generation of telescopes, such as the James Webb Space Telescope (JWST), the ground-based "extremely large" telescopes and the Hydrogen Epoch of Reionization Array (HERA).

To reveal a more literal gap in the sky, the Event Horizon Telescope recently captured a still image of the silhouette of the black hole in the giant galaxy M87. The next goal is to obtain a sequence of images or a video, showing the time variability of the accretion flow around the black hole.

The tradition of still images makes sense when dealing with systems like galaxies, which evolve on a timescale of billions of years. But the universe also exhibits transient fireworks that flare up and dim during a human lifetime. Observing them is the motivation behind the Legacy Survey of Space and Time (LSST) on the Vera C. Rubin Observatory, which will have its first light soon. LSST will be a filming project, documenting nearly a thousand deep multicolor images per patch of the southern sky over a decade and recording the most extensive video of the universe ever taken with its plethora of transients in full glory.

Some of the LSST flares are expected to be the counterparts of gravitational wave sources detected by LIGO/Virgo or LISA. Their discovery will usher in multi-messenger astronomy based on both gravitational and electromagnetic waves emitted by the same sources, providing new insights about the central engines that power these transients. The related standard sirens could serve as new rulers for measuring precise distances in cosmology.

Within the Milky Way, transient events close to Earth could lead to catastrophe. A supernova explosion, for example, could cause a mass extinction on an unprecedented scale. If a meteor similar to the one that hit the unpopulated regions near Chelyabinsk in 2013 or Tunguska in 1908 hit New York City, it could cause a far larger death toll and economic damage than COVID-19. Or consider the impact of a blob of hot gas from the Sun, a so-called coronal mass ejection of the type that missed the Earth in 2012. Such an event could shut off communication systems, disable satellites and damage power grids. Altogether, astronomical alerts about such celestial threats could be crucial for securing the longevity of our species.

Of greatest relevance for our long-term survival is identifying large objects on a collision course with the Earth, similar to the Chicxulub asteroid that killed the dinosaurs 66 million years ago. In 2005, Congress passed a bill requiring NASA to find and track at least 90 percent of all near-Earth objects larger than 140 meters (enough to cause regional devastation) by 2020. Only a third of these objects have been identified in the sky so far. In a recent paper with my undergraduate student Amir Siraj, we explained some puzzling properties of the Chicxulub asteroid as a tidal breakup of a long-period comet that passed close to the sun. If future sky surveys alert us to another fragment whose apparent size grows rapidly against the sky, wed better have a contingency plan to deflect its trajectoryor else immediately call our realtor.

Keeping up with the challenge of precision cosmology for the next few decades can demonstrate that the Hubble constant, which describes the expansion rate of the universe, is not really a constant, in accordance with the expected Sandage-Loeb test. In the long run, the only thing that stays constant is change. The accelerated expansion of the universe under the influence of so-called dark energy will be the ultimate manifestation of extragalactic social distancing in the post-COVID-19 era, preventing any future contact between us and civilizations outside our galaxy.

View post:
A Movie of the Evolving Universe Is Potentially Scary - Scientific American

Edward Jones, in partnership with Age Wave, released a landmark study on Aug. 4 that takes a comprehensive look at retirement in Canada, focusing specifically on four central pillars: health, family, purpose and finances.

The study examines trends affecting the rapid transformation of retirement in Canada as the country's aging population approaches this new stage of life. This includes the impact of COVID-19 which has accelerated many of the trends unearthed in this study.

Despite COVID-19's severe and disproportionate impact on the health of aging adults, older Canadians reported they are coping far better than younger ones. "The Four Pillars of the New Retirement" study of 1,000 Canadian respondents across five-generations revealed that 38 per cent of Gen Z and 36 per cent of millennials said they have suffered mental health declines since the pandemic began, while only 20 per cent of baby boomers and 7 per cent of silent generation respondents said the same. The majority of Canadian retirees (51 per cent) defined retirement as a whole new chapter filled with new choices, freedoms and challenges, and they do so in a more holistic way across four important areas of health, family, purpose and finance.

"We've certainly seen COVID-19's disruptive influence on finances, with the pandemic impacting retirement timing and financial confidence," said David Gunn, Country Leader, Edward Jones Canada. "However, the pandemic has brought families closer and renewed the focus on important discussions about planning earlier for retirement, saving more for emergencies and even talking through end-of-life plans and long-term care costs."

"COVID-19's impact forever changed the reality of many Canadians, yet we've observed a resilience among Canadian retirees in contrast to younger generations," said Ken Dychtwald, Ph.D., psychologist/gerontologist and founder and CEO of Age Wave. "Older Canadians recognize the value of a long-term view, and so as they think about their lives, longevity and legacy, they're able to pull from an array of experiences that help them weather current storms, feel gratitude about many aspects of their lives and still plan for the future."

The four pillars to living well in the "new retirement"

The study goes beyond the impacts of COVID-19 and outlines what makes today's retirement "new". Canada's retirement landscape is unique - increasing longevity and a groundswell of Boomers entering retirement make this one of the most significant societal shifts in history. The study found, changing attitudes and aspirations coupled with external forces (i.e. economic downturns, the pandemic, technology, etc.) have drastically changed the expectations of those approaching or entering retirement and will shape what retirement looks like for generations to come.

The study identified four key pillars for living well in the "new retirement":

When it comes to living well in retirement, 97 per cent of retirees and 99 per cent of those age 75 and over, say that health is more important than wealth. 91 per cent of Canadian retirees say it's never too late to improve health, however, there is an intention/action gap as 51 per cent of Canadian retirees don't exercise regularly, and 33 per cent say they don't maintain a healthy diet. While physical health usually declines with age, for many Canadians mental health rises.

A bright spot coming out of the pandemic is the deepening of family ties. Two-thirds of Gen Z define family as "anyone they love and care for, regardless of whether they are related by blood, marriage or adoption." They believe in "families of affinity" or families of choice. As we approach what is expected to be the largest generational wealth transfer in recent memory, retirees cite they worry about their children more (44 per cent) and are willing to do whatever it takes, personally and financially, to support family members in need, even if it means sacrificing their own financial security (63 per cent). The study also found, 47 per cent of Canadians overall and 30 per cent of Canadians age 65 and over have yet to begin discussing their end-of-life care preferences with their family or close friends.

Retirees with a strong sense of purpose are happier, healthier and live longer, according to the study. This cohort reports they find their strongest sense of purpose from spending time with loved ones (72 per cent) and many (46 per cent) find purpose by being generous or helping others, particularly women (54 per cent). They are also looking for meaningful ways to carve out their free time. They don't just want to keep busy; they want to make useful and rewarding contributions to community and family. As the country's population continues to age, 89 per cent of Canadians agree that there should be more ways for retirees to help in their communities.

According to the study, a chief financial goal amongst retirees, is to have enough resources to provide security (48 per cent) and the freedom to live the lives they want (47 per cent). Retirees' greatest financial worry is not economic uncertainty like recessions, inflation or taxes, despite the disruption associated with COVID-19. Their greatest concerns are encountering unexpected expenses (54 per cent) and the cost of health care, including long-term care (47 per cent). Pre-retirees express even higher concerns about health and long-term care (59 per cent) with three quarters of those who plan to retire (74 per cent) stating they have no idea what their health and long-term care costs may be in retirement.

"Beyond finances, we can help our clients envision and truly realize a holistic and fulfilling retirement, which, we know includes decisions about their health, family and purpose," said Gunn. "Empathy and knowledge allow us to better serve as a trusted advisor to our clients in a human-centered way and work together to achieve what's most important to Canadians and their families."

While the above findings feature a selection of data regarding the new definition of retirement, further examination of the four pillars of health, family, purpose and finances reveal their highly intertwined nature and influence in shaping retirees' overall quality of life. For the complete study, please visit http://www.edwardjones.ca/newretirement

Edward Jones is a full-service investment dealer with more than 850 financial advisors in Canadian communities from coast-to-coast.

Edward Jones Canada, http://www.edwardjones.ca

Age Wave, http://www.agewave.com

AB

Read more from the original source:
In COVID-19 Crisis, Older Canadians Are More Resilient than Younger Generations, Research Finds - The Suburban Newspaper

After the COVID-19 rules about social distancing went into effect, I developed a morning routine of jogging through the woods near my home. During the first months, I focused on the green branches that stretch upward towards the sky, but recently I started to notice the debris of tree trunks lying on the ground. There are many such remnants, eaten by termites, rotting and ultimately dispersing into the underlying soil. A glimpse at the forest reveals a sequence of evolutionary phases in the history of trees that lived or died at different times.

The phenomenon happens in other contexts. For example, I recently completed a nine-year term as chair of the Astronomy Department at Harvard. And only now have I begun to notice the former chairs scattered around me, just like those tree trunks in the woods.

Entering a new stage of life can be humbling. We acquire a false sense of permanence from reviewing the frozen past, as if it were a statue that will never erode. But this view is shortsighted, since each moment can also be seen a new beginning, shaped by forces beyond our control and swirling on a grander scale.

Old-fashioned astronomy was also permeated by a false sense of permanence. Astronomers collected still images of the universe, creating the impression that nothing really changes under the sunor above it, either. But just like the revelation from my stroll through the woods, these snapshots showed stars and galaxies of different ages, at various evolutionary phases along their history. Computer simulations helped us patch together the full story by solving the equations of motion for matter, starting from the initial conditions imprinted on the cosmic microwave background at early cosmic times. By generating snapshots of an artificial cosmos similar to those captured by telescopes, these simulations unraveled our cosmic roots. The scientific insight that emerged is that the likely origins for our existence were quantum fluctuations in the early universe. Perhaps we should add Quantum Mechanics Day to our annual celebrations of Mothers Day and Fathers Day.

There are some missing pages in the photo album made up of our observations, however: the period known as the cosmic dawn, for example, when the first stars and galaxies turned on. These missing pages will be filled in the coming decade by the next generation of telescopes, such as the James Webb Space Telescope (JWST), the ground-based "extremely large" telescopes and the Hydrogen Epoch of Reionization Array (HERA).

To reveal a more literal gap in the sky, the Event Horizon Telescope recently captured a still image of the silhouette of the black hole in the giant galaxy M87. The next goal is to obtain a sequence of images or a video, showing the time variability of the accretion flow around the black hole.

The tradition of still images makes sense when dealing with systems like galaxies, which evolve on a timescale of billions of years. But the universe also exhibits transient fireworks that flare up and dim during a human lifetime. Observing them is the motivation behind the Legacy Survey of Space and Time (LSST) on the Vera C. Rubin Observatory, which will have its first light soon. LSST will be a filming project, documenting nearly a thousand deep multicolor images per patch of the southern sky over a decade and recording the most extensive video of the universe ever taken with its plethora of transients in full glory.

Some of the LSST flares are expected to be the counterparts of gravitational wave sources detected by LIGO/Virgo or LISA. Their discovery will usher in multi-messenger astronomy based on both gravitational and electromagnetic waves emitted by the same sources, providing new insights about the central engines that power these transients. The related standard sirens could serve as new rulers for measuring precise distances in cosmology.

Within the Milky Way, transient events close to Earth could lead to catastrophe. A supernova explosion, for example, could cause a mass extinction on an unprecedented scale. If a meteor similar to the one that hit the unpopulated regions near Chelyabinsk in 2013 or Tunguska in 1908 hit New York City, it could cause a far larger death toll and economic damage than COVID-19. Or consider the impact of a blob of hot gas from the Sun, a so-called coronal mass ejection of the type that missed the Earth in 2012. Such an event could shut off communication systems, disable satellites and damage power grids. Altogether, astronomical alerts about such celestial threats could be crucial for securing the longevity of our species.

Of greatest relevance for our long-term survival is identifying large objects on a collision course with the Earth, similar to the Chicxulub asteroid that killed the dinosaurs 66 million years ago. In 2005, Congress passed a bill requiring NASA to find and track at least 90 percent of all near-Earth objects larger than 140 meters (enough to cause regional devastation) by 2020. Only a third of these objects have been identified in the sky so far. In a recent paper with my undergraduate student Amir Siraj, we explained some puzzling properties of the Chicxulub asteroid as a tidal breakup of a long-period comet that passed close to the sun. If future sky surveys alert us to another fragment whose apparent size grows rapidly against the sky, wed better have a contingency plan to deflect its trajectoryor else immediately call our realtor.

Keeping up with the challenge of precision cosmology for the next few decades can demonstrate that the Hubble constant, which describes the expansion rate of the universe, is not really a constant, in accordance with the expected Sandage-Loeb test. In the long run, the only thing that stays constant is change. The accelerated expansion of the universe under the influence of so-called dark energy will be the ultimate manifestation of extragalactic social distancing in the post-COVID-19 era, preventing any future contact between us and civilizations outside our galaxy.

See the original post here:
A Movie of the Evolving Universe, Potentially Scary - Scientific American

Coherent Market Insights announced that its published an exclusive report namely Global Mesenchymal Stem Cells Market by Manufacturers, Regions, Type, and Application, Forecast to 2027 in its research database with report summary, table of content, research methodologies, and data sources. The research study offers a substantial knowledge platform for entrants and investors as well as veteran companies, manufacturers functioning in the Worldwide Mesenchymal Stem Cells Market. This is an informative study covering the market with an in-depth analysis and portraying the current state of affairs in the industry.

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Mesenchymal Stem Cells Market With Top 20 Countries data Analysis, Growth by Top Companies, Trends by Types and Application, Forecast Analysis to 2026...

Olivia de Havilland, one of the last pillars of Hollywood royalty and a contemporary of Bette Davis and Errol Flynn, died "peacefully from natural causes" Sunday at the age of 104, talent agent Jim Wilhelm told USA TODAY. Her death marks the passing of one of the last stars of classic films of the 1930s, an actress before her time in the fight for equality, and an icon who took on the studio system and won.

Best known for her sweet-natured role as Melanie Hamilton in "Gone With the Wind," the two-time Oscar winner (for 1946's "To Each His Own" and 1949's "The Heiress") will be remembered most for her beautiful diction, an air of refinement and gumption, and grace on and off camera. Outspoken and steely in real life, de Havilland starred in more than 50 films on the big and small screen from 1935 to 1988, and was known as a staunch advocate for actors rights and creative freedom in Hollywood.

Bound by the grip Warner Bros. held on her career, the 27-year-old star sued the studio in 1943, prompting a collapse of oppressive long-term contracts in Hollywood. And in the latter years of her life, the British-American actress reminded she was no pushover, making headlines by filing a lawsuit in Los Angeles over being portrayed as a gossip monger in Ryan Murphys FX show "Feud: Bette and Joan," which chronicled the longtime rivalry between actresses Davis and Joan Crawford.

She was born Olivia Mary de Havilland in 1916 in Tokyo, where her father Walter Augustus de Havilland taught English at the Imperial University and then became a patent attorney. Her mother Lilian Augusta Ruse was a stage actress educated at the Royal Academy of Dramatic Art in London, but she left her career to move to Japan with her husband.

On a family trip to California in 1919, Olivia became ill with a bronchial condition and her younger sister Joan (later to become the actress Joan Fontaine) developed pneumonia. Lilian decided to remain in California with Joan and Olivia for her daughters health. They settled in Saratoga, a suburb of San Francisco, while her father abandoned the family and returned to Japan. De Havillands mother divorced in 1925 and married George Fontaine, a strict stepfather the girls resented.

Fontaine died in 2013 at age 96. De Havilland's death was also preceded by son Benjamin Goodrich in 1991. She is survived by her daughter, Gisele Galante Chulack, son-in-law Andrew Chulack and niece Deborah Dozier Potter. Funeral arrangements will be private, Wilhelm said.

After making her Hollywood debut in a version of Shakespeare's "A Midsummer Night's Dream," de Havilland - named for the Bard's "Twelfth Night" character Olivia - made an early mark opposite Flynn. In 1934, she had signed a contract with Warner Bros., who decided to pair her with the then-unknown Australian They starred a year later in "Captain Blood," a swashbuckling hit that made the two of them bonafide stars, and they made seven more movies as one of Hollywoods most memorable on-screen romantic pairings. She played Maid Marian to Flynn's title rogue in "The Adventures of Robin Hood" in 1938, and they last appeared together in 1941s "They Died With Their Boots On."

With David O. Selznicks 1939 Civil War epic "Gone With the Wind," de Havilland said at the time that having read the Margaret Mitchell novel, she knew she could bring the character of Melanie to life, and the actress' soft voice and graceful manner made her the perfect fit for a pivotal role: Melanie's indelible goodness saved Scarlett OHara (Vivien Leigh) from social ruin more than once and even touched Scarletts hard heart. Though far less showy than Scarlett, de Havillands iconic role is deeply etched in audiences hearts.

The character earned de Havilland her first Oscar nomination, for best supporting actress, but she lost to her "Wind" co-star Hattie McDaniel. De Havilland's second nod came for 1941s "Hold Back the Dawn," where she shared the best actress category with her sister, who won for "Suspicion." De Havilland took home her own best actress Oscar five years later, for her performance in "To Each His Own," and they are still the only siblings ever to have won lead acting Academy Awards.

But de Havilland and Fontaine fostered a heated competitiveness that lasted all their lives, from childhood to stardom. That rivalry rumored to have escalated into a feud where the two didnt speak was the subject of Hollywood gossip for decades.

In 2016, three years after her sister's death, de Havilland finally broke her silence on their relationship to the Associated Press: "A feud implies continuing hostile conduct between two parties. I cannot think of a single instance wherein I initiated hostile behavior." However, she added, "I can think of many occasions where my reaction to deliberately inconsiderate behavior was defensive.

In 1949, Fontaine put it differently, telling columnist Hedda Hopper: You see, in our family, Olivia was always the breadwinner, and I the no-talent, no-future little sister not good for much more than paying her share of the rent."

De Havilland referred to her sister as Dragon Lady.

"Dragon Lady, as I eventually decided to call her, was a brilliant, multi-talented person, but with an astigmatism in her perception of people and events, which often caused her to react in an unfair and even injurious way," de Havilland said in 2016.

De Havilland, who won her second best actress Oscar for "The Heiress," was also nominated for her performance in 1948s "The Snake Pit," one of the earliest films to feature a realistic portrayal of mental illness. That role also cemented her reputation for embracing flawed and unglamorous characters.

I believed in following Bette Davis example, she told the Los Angeles Times in 1988. She didn't care whether she looked good or bad. She just wanted to play complex, interesting, fascinating parts, a variety of human experience. I wanted Melanie to be just one of the images. Let's have a few others.

Being as well-received as she was both by the public and critically for her part in "Gone With the Wind," de Havilland longed for more substantial parts early in her career, particularly more serious ones than as Flynns demure leading lady, who was usually a damsel in distress. But Warner Bros. did not support her efforts. De Havilland grew increasingly frustrated by the lack of challenging roles and began to reject scripts.

While De Havilland wanted to pursue opportunities with other studios, Warner Bros. told her they added six months more to her seven-year contract for times she had been on suspension. (Legally, studios could suspend contract players for rejecting a role, then add that time to the contract period.)

At the urging of her lawyer, she sued Warner Bros., supported by the Screen Actors Guild. The case went to the Supreme Court of California and the court ruled in her favor in 1945. Known as the de Havilland Law, the landmark decision proved to be one of the most important and far-reaching legal rulings in Hollywood, reducing the power of the studios and giving greater creative freedom to actors.

Performers of that era and later benefited from her legal case, and the law won de Havilland much respect among her peers and colleagues. Fontaine was even quoted as saying Hollywood owes Olivia a great deal. But Warner Bros. circulated a punitive letter that essentially blacklisted de Havilland. She did not work for a film studio for two years until Paramount signed her in 1946.

"As soon as my victory was legally confirmed and I was free to choose the films that I made, Paramount presented me with the script of 'To Each His Own,' " playing an unwed teenage mother. This was exactly the kind of challenge for which I fought that case," she told the AP with pride in 2016.

In addition to championing actors rights, de Havilland was known for her liberal political stance. She organized a fight for control of the Independent Citizens Committee of the Arts, Sciences and Professions, which she felt was being manipulated by a small group of Communists. She failed and then resigned, triggering a wave of resignations, including that of an actor she had recruited to the group, Ronald Reagan. Even though she had very publicly worked to organize Hollywood resistance to Soviet influence, she was called to testify before the House Un-American Activities Committee in 1958 because of her vocal liberal activism.

On the personal front, de Havilland was romantically involved with Flynn, Jimmy Stewart, director John Huston and filmmaking mogul Howard Hughes, though Havilland eventually married Navy veteran and novelist Marcus Goodrich in 1946, before divorcing in 1953. They had one son, Benjamin, who died in 1991 after a battle with Hodgkins disease.

She wed French journalist Pierre Galante in 1955, moved to Paris, and had a daughter, Gisele. De Havilland's adjustment to Parisian life was recounted in her 1962 memoir "Every Frenchman Has One." The couple divorced in 1979.

De Havilland only appeared occasionally in films in the 1950s and turned down the role of Blanche Dubois (which won Leigh her second best actress Oscar) in 1951's "A Streetcar Named Desire." While some thought it had to do with the suggestive themes of the story, she said in 2006 that she declined the part because she had recently given birth to her son.

Her few film roles in the 60s included "Lady in a Cage" (1964) and "Hush Hush Sweet Charlotte" (1964). In 1965, she was the first woman to preside on a jury for the Cannes Film Festival.

De Havilland continued acting in films until the late 1970s and on television through the 1980s. She won a Golden Globe in 1987 and also earned an Emmy nomination for "Anastasia: The Mystery of Anna." And In 2009, she lent her distinctive voice to the narration of a documentary on Alzheimers disease entitled "I Remember Better When I Paint."

In her later years, she maintained perspective on her impressive longevity: All the artists I had known during the Golden Era (live) elsewhere, she said in 2016, including the after world.

Originally posted here:
Olivia de Havilland, Gone With the Wind actress and Hollywood royalty, dies at 104 - Destin Log

Soy has been part of traditional Asian diets for the past millennium, and in recent years, its slowly become a staple in many vegans, vegetarian and plant-based diets. Now while the move away from meat products is welcome, you cant deny that youve heard the rumors. There are rumors about whether soy foods are a welcome alternative to meat or rather a serious health risk that we should be avoiding.

Soy continues to be one of the most controversial foods on the planet with many praising its benefits, whilst others claim that its actually bad for you especially because it contains plant estrogens.

So, which is it? Is soy the answer to all things plant-based, or should we avoid it just as much as we avoid red meat? Read on to find out.

Soy products are made from soybeans, which are plant food that belongs to the pea family. They come in many colors, most notably green, yellow and black. Whilst the majority of soybeans are processed into soy foods, soybeans also help to produce soy oil as well as protein powder and soy isoflavone supplements. Whats more, some people even use the remnants of soy oil processing as food for farm animals and pets.

Soy has been the subject of many studies, and before we delve into the benefits of soy, it should be noted that many soy-based studies have been financed by the soy industry. It is something worth keeping in mind.

Lignans and isoflavones are phytoestrogens found in the body that mimic the sex hormone estrogen. Research suggests that in mimicking estrogen, these two compounds can offer cancer-protective benefits.

For instance, a 2014 studyfound a strong correlation betweensoy-food and a 26% reduced risk of developing breast cancer. A more recent study echoed these findings by suggesting that suggested isoflavones in soy can help reduce the risk of hormone associated cancers, such as breast cancer.

If youre battling with lockdown weight, then you may need to look to soy-based products. Thats at least according to one animal study.

The study, published last yearin the journal Molecules, found thatcertain compounds in soy isoflavones helped to prevent the buildup of fat around the organsof rats.That said, the researchers believe that the findings provesoy isoflavones potential for managing obesity.

Studies suggest that soy may help you on your journey in starting a family.

One studyfound an association between soy consumptionand better outcomes for women undergoing fertility treatments. A separate study also found that womenwho ate soy before in vitro fertilization (IVF) faced a higher chance of a successful pregnancy than those who did not.

Funnily enough, a studypublished in the journal Andrology found that male soy food intake did not affect or influence IVF outcomes.

If youre battling with uncomfortable menopausal symptoms like hot flashes, soy foods may help.

Compounds found in soy can mimic estrogen, and this may then help alleviate menopausal symptoms.

A reviewof 17 studiespublished in the journal Menopause found that women who had takenadailydose of soy isoflavones for 12 weeks experienced 20.6% fewer hot flashesanda 26.2% reduction in symptom severityover the course of the study.

The isoflavones found in soy may help to improve insulin sensitivity. In fact, a previously mentioned study suggested that soy isoflavones may help to reduce the risk of diabetes. Exactly how it does this is still unknown.

Prostate cancer is currently the second most common cancer found in men worldwide, so its important to take the right precautions in reducing ones risk and it appears that consuming more soy products may help.

A2018reviewof 30 studies (a total of 266,000 men across North America, Europe, and Asia) found a strong correlation betweenhigh soy consumption anda lower risk of developing prostate cancer. The study found a 29% reduced risk in regards toall soy foods and a 35% lower risk when it came to non-fermented soy foods.

In 2000, the FDA supported claims that soy protein can support heart health, and the American Heart Association supported these claims (1).That said, in2008, the AHA sent a letter to the FDA requesting that it reconsider its authorized health claim. This then begs the question of what does current research say about soy products and heart disease?

Well, a 2015 reviewthat looked at 35 studies found that soy products helped to reduce levels ofLDL (bad) cholesterol and total cholesterol while raising HDL (good) cholesterol. The researchers also noted that soy supplements did not have the same cholesterol-lowering effect as soy foods.

Another review study published in 2017 looked at 17 observational studies, and that found a strong link between eating more soy foods and a 17% lowered risk of cardiovascular disease and coronary heart disease as well as an 18% lowered risk of stroke.

As mentioned, soy contains phytoestrogens which are plant compounds that can mimic the human hormone estrogen. The most popular of these plant compounds are isoflavones, and it is often linked to a number of soys health benefits. Unfortunately, its also responsible for a few of its health concerns.

This is because disrupting your hormones can affect the way your body functions. In men, hormonal imbalances can affect their libido, energy and it may even increase the risk of man boobs. With women, hormonal imbalances wont only disrupt your menstrual cycle, but it can also affect fertility and even increase the risk for some cancers. A reviewpublished in theJournal of Nutritionfound that high consumption of soy can affect ovarian functioning.

Some formulapreparationscontain soyand a baby consuming hormones in large quantitiesis sure to affect their health. Research suggeststhat exposure to soy phytoestrogens early in life can alter the timing and character of breast development(2). Another studylinkedsoy formula consumption to a greater risk of developing uterine fibroids.

Goitrogens are compounds found in soy that may affect thyroid function. According to research, goitrogens affect how much iodine your thyroid gets and this can lead to hypothyroid problems (3).

In fact, a study examining women and men on a vegetarian diet found that women with higher soy intake faced an increased risk of having higher levels of thyroid-stimulating hormone (TSH), which maysignify an underactive thyroid.

Phytates are anti-nutrients naturally found in a number of foods, including soy.

Being anti-nutrients, phytates affects the bodys absorption of minerals. These include zinc, calcium, iron, and magnesium, which can increase the risk of deficiencies.

While you can neutralize phytates in other foods through soaking and slow cooking, the phytates found in soy can only be neutralized through long fermentation.

Trypsin is a digestive enzyme that helps the body break down and digest protein.

Lack of trypsin can cause digestive problems. With soy being high in trypsin inhibitors, eating soy may increase the risk of stomach cramps and diarrhea.

A large majority of soybeans grown in the United States are genetically modified. While more studies are still needed, there has been some research highlighting the negative health effects of GMO foods (4).

Whats more, a lot of soybean crops are sprayed with the chemical herbicidesglyphosate, whichis rich in controversy.

While some studies suggest that soy can help with fertility, other studies have found that soy intake may negatively affect fertility.

A study done on 11688 women found an association between high soy isoflavone intake and a lower likelihood of having been pregnant or giving birth to a live child.

Its clear that more research is needed to properly examine the relationship between soy intake and fertility.

Now you may be reading this and wondering if soy is so bad, which is it so prominent in Asian diets and why is the Asian population so healthy?

Well, the fact is, Asians do not eat a lot of soy. Rather, they consume small amounts of soy (around 10 grams a day 2 teaspoons!) and most of it is fermented, such as nato, miso, or tempeh.

Its clear that more research is needed to determine all the positive and negative effects of eating soy. If you are looking to eat soy, the best thing to do would be to pick minimally processed forms of soy.

Whole soy products are the least processed, and they include soybeans and edamame. Soy milk and tofu are also included in this list as they are made from whole soybeans.

Fermented soy foods are processed by boiling, fermenting, and refining soybeans. Theyre also safer to consume as they are free of antinutrients. The most common fermented soy products include soy sauce, tempeh, and miso.

If you have a high risk for hormonal cancers and thyroid disorders, it would be advisable to stay clear of soy and soy-based foods.

Its clear that more high-quality research is needed to fully determine the effect soy consumption can have on our overall health. So, if you really want to be careful, you can opt to skip the soy all together and focus on other plant-based meat substitutes that boost your health, rather than jeopardize it.

Link:
Soy Foods: Are They Good Or Bad For Your Health? - Longevity LIVE

Myotis myotis(Greater mouse-eared bat), Credit: Olivier Farcy.

Bats are the only flying mammals in the animal kingdom but thats not all theyre known for. Bats have a number of quite extreme adaptations, such as echolocation, highly sensitive sensory perception, significant longevity for their size, resistance to cancer, and exceptional immunity to viral infections. In fact, the coronavirus that has caused the world to grind to a halt is believed to have evolved inside bats, before jumping into humans.

No doubt, bats are amazing creatures. Now, for the first time, researchers have sequenced the raw genetic material that contains the instructions for bats unique, superpower-like adaptations.

Given these exquisite bat genomes, we can now better understand how bats tolerate viruses, slow down aging, and have evolved flight and echolocation. These genomes are the tools needed to identify the genetic solutions evolved in bats that ultimately could be harnessed to alleviate human aging and disease, Emma Teeling, senior author of the new study and a researcher at the University College Dublin, said in a statement.

Teeling and colleagues affiliated with Bat1k, a global consortium of researchers on a mission to sequence the genomes of every one of the 14,210 living bat species, published a study today in which they describe the genomes of six bat species.

The genomes were highly accurately analyzed with state-of-the-art sequencing technology and are about 10 times more complete than any other bat genome published in the past.

Using the latest DNA sequencing technologies and new computing methods for such data, we have 96-99% of each bat genome in chromosome level reconstructions an unprecedented quality akin to for example the current human genome reference which is the result of over a decade of intensive finishing efforts. As such, these bat genomes provide a superb foundation for experimentation and evolutionary studies of bats fascinating abilities and physiological properties Eugene Myers, senior author of the study and Director of Max Planck Institute of Molecular Cell Biology and Genetics, and the Center for Systems Biology, said in a statement.

The first six bat genomes that were sequenced part of the Bat1K global genome consortium belonged to the greater horseshoe bat (Rhinolophus ferrumequinum), the Egyptian fruit bat (Rousettus aegyptiacus), the pale spear-nosed bat (Phyllostomus discolor), the greater mouse-eared bat (Myotis myotis), the Kuhls pipistrelle (Pipistrellus kuhlii) and the velvety free-tailed bat (Molossus molossus).

Their genetic blueprints were compared to 42 other mammals, which enabled the researchers to pinpoint the position of bats on the mammalian tree of life.

Due to their many unique quirks, the question of where bats fit in on the tree of life has always been unresolved. But using novel phylogenetic methods and molecular datasets, the evidence suggests that bats are most closely related to Ferreuungulata a group of mammals that includes carnivores like dogs, cats, and seals, as well as pangolins, whales, and hoofed mammals. Not a very narrow definition seeing how bats and cows are on the same roster, but as more bat genomes are sequenced their taxonomy can be refined further.

The side-to-side comparison of different mammalian genomes also helped tease apart adaptations that are unique to bats through the loss and gain of certain genes.

For instance, the genes that enable bats famous echolocation were selected for in the ancestral branch of bats, suggesting this is an ancient trait in this group of mammals.

There was also evidence of gene loss and gain involved in immunity, particularly the expression of antiviral APOBEC3 genes. This may explain why bats have exceptional immunity that makes them extremely tolerant to viral infections.

In this day and age, understanding the molecular mechanisms that allow bats to withstand coronaviruses may lead to new approaches, therapies, and vaccines meant to increase human survivability in the face of COVID-19.

Having such complete genomes allowed us to identify regulatory regions that control gene expression that are unique to bats. Importantly we were able to validate unique bat microRNAs in the lab to show their consequences for gene regulation. In the future we can use these genomes to understand how regulatory regions and epigenomics contributed to the extraordinary adaptations we see in bats. Sonja Vernes, Co-Founding Director Bat 1K, Max Planck Institute for Psycholinguistics, Nijmegen, Senior Author

Although the researchers sequenced the genomes of only six bats, theyve already learned quite a lot. However, this is merely the beginning there are still more than 1,400 known bat species to go.

The findings appeared in the journal Nature.

Original post:
Scientists sequence the genomes of six bat species for clues to their unique features - ZME Science

Moss bounds happily through the bush showing the usual exuberance of a young labrador. Despite this looking like play, he is on a serious mission to help fight the extinction of some of our most critically-endangered species.

Moss is a detection dog in training. Unlike other detection dogs, who might sniff out drugs or explosives, hell be finding some of Victorias smallest, best camouflaged and most elusive animals.

These dogs use their exceptional olfactory senses to locate everything from koalas high in the trees, desert tortoises burrowed deep under soil and even whales often more effectively than any human team could aspire to.

What makes Moss unique, however, is hell not only find endangered species in the wild, but will also be part of a larger team helping endangered species breed in captivity. These dogs will be the first in the world to do this, starting with a ground-breaking trial with Tasmanian devils.

Wildlife detection dogs are a very rare type of dog they are highly motivated, engaged and energetic, but also incredibly reliable and safe around the smallest of creatures. And Moss is the first dog to join Zoos Victorias Detection Dog squad, a permanent group of highly trained dogs that will live at Healesville Sanctuary.

Moss was adopted at 14 months old, after he somewhat failed at being a family pet. He is a hurricane of energy with an intelligent and playful mind. Hes thriving with a job to keep him occupied and new challenges for his busy brain.

One sign he was perfect for this program was his indifference to the free range chickens at his foster home. For obvious reasons, a dog who likes chasing chickens wouldnt be a good candidate for protecting some of Australias rarest feathered treasures.

Currently, Moss is learning crucial foundational skills, and getting plenty of exposure to different environments. Equally important, he is developing a deep bond and trust with his handlers.

The detection dog-handler bond is crucial not only for his happiness, but also for working success and longevity. Research from 2018 found a strong bond between a handler and their dog dramatically improved the dogs detection results and reduced signs of stress.

Healesville Sanctuary breeds endangered Tasmanian Devils every year as part of an insurance program to support conservation and research. This program is crucial to help protect the devil following an estimated 80% decline in the wild due to a horrific transmissible cancer, Devil Facial Tumour Disease.

But managing a predator thats shy, nocturnal and prefers to be left alone can be tricky. Wildlife, including Tasmanian devils, need a hands-off approach where possible, so they can maintain natural behaviours and thrive in their environment.

In the wild, devils leave scats or faeces at communal latrine sites and use scent for communication. Male devils can tell a female is ready to mate by smelling her scat. And we think dogs could be trained to detect this, too.

We aim to train dogs to detect an odour profile in the collected scat of female devils coming into their receptive (oestrus) periods, so we can introduce females and suitable males to breed at the optimal time. The odour profile will be further verified via laboratory analyses of hormones in the scats.

The project will also explore whether dogs can detect pregnancy and lactation in the devils. Currently, the best way to determine if a female has young is to look in her pouch, but our preference is to remain at a distance during this important time while females settle into being new mums.

If the dogs are able to smell a scat sample, while never coming into contact with the devil, and identify that a female is lactating with small joeys in her pouch, we can support her for example, by increasing her food while keeping a comfortable distance.

The results from this devil breeding research could offer innovative new options for endangered species breeding programs around the world. Wildlife detection in the field means we can more accurately monitor some of our most critically endangered species, and quickly assess the impact of catastrophic events such as bushfires.

Detection dogs are the perfect intermediary between people and wildlife they can sniff out what we cant and communicate with us as a team.

And over the next few years, the Detection Dog Squad will expand to five full-time canines. They will all be selected based on their personalities rather than specific breeds, so will likely come in all shapes and sizes.

Dogs may yet go from being mans best friend to the devils best friend and beyond, all starting with a happy labrador named Moss.

La Toya Jamieson, Wildlife Detection Dog Specialist, La Trobe University. Marissa Parrott, Reproductive Biologist, Wildlife Conservation & Science, Zoos Victoria, and Honorary Research Associate, BioSciences, University of Melbourne.

This article first appeared on The Conversation.

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Meet Moss, the dog in charge of protecting Australias rarest feathered creatures - Scroll.in