Stanford study finds high energy use provides little benefit for health and well-being in richer nations – Stanford University News

April 12, 2022

Analysis of data from 140 countries suggests many rich countries could use less energy per capita without compromising health, happiness or prosperity. Countries struggling with energy poverty may be able to maximize well-being with less energy than previously thought.

By Josie Garthwaite

A good, long life requires energy: to illuminate hospitals, homes and schools, and make it possible to work, cook meals and study without inhaling toxic smoke or spending a full day collecting fuel. But at some point, energy stops being the limiting factor for well-being.

A child studies by lantern light. Globally, 1.2 billion people live without access to electricity. (Image credit: Triloks/iStock)

New research from Stanford University suggests that point the threshold beyond which greater energy use loses its link to national-level improvements in measures of health, economy and environment is surprisingly low.

The results, published April 12 in Ecosphere, suggest nations with high per capita energy use, such as the United States and Canada, could scale back consumption while maintaining or even improving well-being. Countries where energy poverty remains a challenge, meanwhile, may be able to maximize national health and prosperity with far less energy than scholars once thought.

The authors found todays average global energy consumption of 79 gigajoules per person could, in principle, allow everyone on Earth to approach the maximum health, happiness and environmental well-being of the most prosperous countries today, if distributed equitably.

Other scholars have sought for decades to pin down the bare minimum of energy supply required per capita to achieve a decent quality of life. Early estimates suggested a range of 10 to 65 gigajoules per person. Its one thing to identify where people dont have enough energy; its another to identify what our target might be, said lead study author Rob Jackson, professor of Earth system science at Stanfords School of Earth, Energy & Environmental Sciences (Stanford Earth). How much additional energy needs to be provided?

Answering this question is not just an academic exercise. It is central to mapping out how the world can achieve international climate goals while building out modern energy services for the 1.2 billion people who live without electricity and the 2.7 billion who cook on stoves linked to 3.5 million premature deaths each year from household air pollution.

We need to address equity in energy use and greenhouse gas emissions. Among the least sustainable ways to do that would be to raise everyone to the levels of consumption we have in the United States, said Jackson, who is the Michelle and Kevin Douglas Provostial Professor at Stanford and a senior fellow at the Stanford Woods Institute for the Environment and at the Precourt Institute for Energy. Even using renewables, that would have serious, possibly catastrophic consequences for the environment, because of the materials, land and resources required to supply hundreds of gigajoules per year for each of the 8.5 billion people projected to inhabit Earth in 2030.

Reducing global population size would also tamp down total energy and resource needs, Jackson said. But there are other ways to close the global energy gap with fewer emissions. The new research provides a gauge for measuring some of the human impacts of one of them: reducing per capita energy use in what Jackson called energy profligate countries, while raising the rest of the worlds energy supply to comparable levels.

The new conclusions derive from statistical analysis of energy-use data for 140 countries from 1971 to 2018, as well as global data for nine metrics related to human well-being. Many of those metrics align with the United Nations Sustainable Development Goals, a set of objectives aimed at ending an array of inequities while taking the risks of climate change into account.

The researchers looked at the primary energy supply, which includes all energy production minus exports, international marine and aviation bunkers, and changes in the amount of fuel held in storage, for each of the 140 countries. They then separated out the total energy that goes into increasing well-being from the energy that is wasted or employed for other purposes, such as trade.

Recognizing that well-being is likely to be limited by multiple factors, including income and GDP, the authors examined whether per capita energy use could decline in some countries while maintaining quality of life.

Across most metrics, including life expectancy, infant mortality, happiness, food supply, access to basic sanitation services and access to electricity, the authors found performance improved steeply, then peaked with annual energy use averaging 10 to 75 gigajoules per person. Thats less than the 2018 world average of 79 gigajoules per capita, and, at the higher end of the range, about a quarter of the U.S. average of 284 gigajoules per person.

U.S. energy use per capita has fallen slightly since the late 1970s, largely because of improvements in energy efficiency, but it remains high in part because of the nations outsize demands for energy for transportation.

In most countries that consume much more energy than the global average, further increasing energy use per capita might only marginally improve human well-being, said coauthor Chenghao Wang, a postdoctoral scholar in Jacksons lab and also a research fellow at the Stanford Center for Longevity.

The new study reveals at least 10 countries punching above their weight, with greater well-being than most other countries using similar amounts of energy per capita. The high performers include Albania, Bangladesh, Cuba, Denmark, Finland, Iceland, Malta, Morocco, Norway and Sri Lanka.

Air quality stands apart from the other metrics examined by the authors, in that across 133 countries, it continued to improve with per capita energy use as high as 125 gigajoules. Thats on par with the annual per capita energy use of Denmark in 2018, and slightly higher than that of China. One reason may be that the early stages of energy development have historically been dominated by dirtier fossil fuels.

In the U.S., energy use rose steeply after World War II decades before federally imposed limits on pollution from tailpipes and smokestacks spurred improvements in the nations air quality. Wealthier countries like the U.S. tend to clean up their air only after they have built up wealth and the populace demands action, Jackson said.

Past research has shown that higher income doesnt necessarily lead to better and happier lives, said study co-author Anders Ahlstrm, a climate scientist at Lund University who worked on the research as a postdoctoral scholar in Jacksons lab at Stanford. Energy supply is similar to income in that way: Excess energy supply has marginal returns.

Co-authors are affiliated with Stockholm University, Princeton University and Jadavpur University.

This research was supported by Stanfords Center for Advanced Study in the Behavioral Sciences and the Stanford Center on Longevitys New Map of Life initiative.

To read all stories about Stanford science, subscribe to the biweeklyStanford Science Digest.

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Stanford study finds high energy use provides little benefit for health and well-being in richer nations - Stanford University News

Scientists De-Aged a Woman’s Skin Cells by 30 Years – The Daily Beast

While the Fountain of Youth is the stuff of legend, the search for a way to stop humans from aging is happening as we speakinside the laboratory.

In a study published in the journal eLife on April 8, scientists at Babraham Institute in the U.K. managed to de-age the skin cells of a 53-year-old woman by 30 years in a petri dish. Looking at age-related biological changes in the DNA, these genetically-modified younger cells appeared and behaved as any 23-year-old skin cell should. Notably, the team was also able to de-age the cells in less than two weeks.

The techniques used in this experiment have been around for the last few decades. However, with the woman's skin cells, the researchers managed to shave off time from the usually long process while also avoiding the problems reprogrammed cells can often run into, like inadvertently turning cancerous.

This kind of work is very important, Dr. Ivona Percec, a plastic surgeon and stem cell researcher at the University of Pennsylvania School of Medicine, who was not involved in the study, told The Daily Beast. And its one thats been sought out by many scientists in order to reverse or delay aging.

Most rejuvenation or regeneration research makes use of human stem cells, which have the unique ability to develop into any other type of cell our body needs, such as muscle and brain cells. Stem cells can also renew themselves over time and serve as an internal repair system, replacing lost or damaged cells during a persons lifetime. But stem cells are quite difficult to produce in the laband are often rejected by the body when used in different types of therapies.

To get around these hurdles, scientists have been creating their own lab-grown stem cells called induced pluripotent stem cells (iPSCs). They are created by taking any cell in our body and genetically editing it to resemble an embryonic stem cell, George Sen, a molecular biologist at the University of California San Diego who was not involved in the study, told The Daily Beast in an email.

To make their iPSCs, the Babraham researchers reversed the cellular clock on their 53-year-old skin cells by bathing them in a chemical solution that encourages the growth of proteins that reshape a cells DNA. To control how far they de-age the cells, the researchers allowed the bath to run for a little less than two weeks than the typical 50 days. Then they assessed the age of the skin cells by looking for age-related biological changes.

I remember the day I got the results back and I didn't quite believe that some of the cells were 30 years younger than they were supposed to be, Dilgeet Gill, a biomedical researcher at Babraham Institute and lead author of the study, told the BBC. It was a very exciting day!"

Young fibroblasts in the first image. The next two images are after 10 days, right with treatment. The last two images are after 13 days, right with treatment. Red shows collagen production which has been restored.

Ftima Santos

These newly minted young skin cells, called fibroblasts, produce collagen, which is a protein responsible for healthy joints and elastic skin throughout the body. When researchers cut through the cell layer (like how if you injure your skin), the fibroblasts moved into the gash quickly to fill it, unlike the older cells.

Though the findings are quite encouraging, were still some ways from seeing this new de-aging technique used in a clinical setting. Experts also have some lingering questions regarding how long exactly this rejuvenation lasts and whether the new technique actually improves a cells lifespan.

The authors only looked for a short period of time after [applying Yamanaka factors] but what happens once the cell has divided a few times? Does the molecular clock catch up? asked Sen. The authors also never tested whether the de-aged fibroblasts behaved as younger fibroblasts in live animal models. This question would need to be addressed before this can be used as therapy.

Whether this is the key to the Fountain of Youth remains to be seen.

Dr. Johann Gudjonsson, University of Michigan

Dr. Johann Gudjonsson, a dermatologist who studies inflammatory skin conditions at The University of Michigan and wasn't involved in the study, is also skeptical of the experiment.

Whether this is the key to the Fountain of Youth remains to be seen, Gudjonsson told The Daily Beast in an email. He explained that telomeres, which are the caps binding the ends of DNA and shorten as we age, didnt appear to improve with the new studys treatment. Therefore while the function and state of the cells are rejuvenated it may not mean that their lifespan has changed, he said.

Even if longevity and immediate clinical applications arent in the cards, this new study does offer an interesting proof of concept for future medical research and potentially combating aging.

If this process can be applied to other cell types, one can imagine rejuvenating that particular cell type and using it to restore an aged/failing organ, said Sen. I believe this line of research has a lot of potential and we are just starting to understand the rules of how to reprogram cells.

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Scientists De-Aged a Woman's Skin Cells by 30 Years - The Daily Beast

How to have a longevity mindset for anti-aging technology – Fast Company

The worlds billionaires arepouringmoney into age-reversal investments.

Last September, it came out thatJeff Bezos had invested in Altos Labs, a company pursuing biological reprogramming technology. Reprogramming is the scientific term for turning old cells young again. It was discovered in 2012 by Japanese scientist Shinya Yamanaka, who called it a potential elixir of life. The Nobel Prize in Medicine Committeeseemed to agree.

Bezosand Altosarent the only ones.

Theres Google-backedCalico Labs, also focused on longevity via reprogramming. AndLineage Cell Therapeutics, backed by BlackRock, Raffles Capital Management, Wells Fargo, and others.

Coinbase Co-founder and CEO Brian Armstrong recently invested in a company working to radically extend human healthspan using epigenetic reprogramming therapies. Altogether, the anti-aging industry isexpected to grow toover $64 billionby 2026, a 45% increase from its 2020 value ($44 billion).

So, why are billionaires like Jeff Bezos investing in age-reversal or anti-aging tech?

Because they have aLongevity Mindset.

One way to understand the Longevity Mindset is by looking at its opposite.

Most people take the aging process for granted. If theyre disciplined, healthy, and lucky, theyll get 20 or so years of youth, start declining in their 40s, and die sometime between 60 and 80.

They accept that life expectancy is 81.2 years for females and 76.4 years for malesnothing they can do, just take the lemons and make lemonade.

And who can blame them? Nearly every human institutiongovernments, the insurance industry, medicine, religionis organized around this mindset.

The anti-Longevity Mindset is: mortality is inevitable, youth is fleeting.

So, the Longevity Mindset is: mortality is avoidable, youth is extendable.

If that sounds shocking to you, youre not the only one. For years, scientists supporting a Longevity Mindset were shunned, and as a result longevity studies were tabled for fear of losing grant funding.

But medicine has evolved.

Weve entered a period ofexponential medicine: Innovations like genome sequencing, RNA transcriptomics, Wnt pathway modifiers, vaccines, CRISPR, liquid biopsies, CAR-T cells, Gene Therapy, exosomes, and stem cells are just a sampling of the technologies that the worlds billionaires are fast-tracking.

Free from the narrow paradigm of academia, these scientists earn as much as five to tentimesa top professors salary by working for Altos and others.

Ultimately,aging is a diseasea disease that many of the most powerful people on the planet believe can be slowed, stopped, even reversed.

Thats the spirit of the Longevity Mindset.

Examine and assess the six basic areas of life that everyone, whether you live on the margins or in a mansion, must negotiate.

Laying the foundation of a Longevity Mindset doesnt take any capital investment. Everyone has beliefs, a media diet, and a community. Everyone has to sleep, eat, and move around.

In the background, billionaires like Bezos are accelerating the industry, working to bring cutting-edge longevity tech to human beings.

When they do, will you be ready?

This article originally appeared in Minutes and is reprinted with permission.

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How to have a longevity mindset for anti-aging technology - Fast Company

Gigantism Is a Never-Ending Temptation for Engineers and Designers – IEEE Spectrum

There is a fundamental difference between what can be designed and built and what makes sense. History provides a lesson in the shape of record-setting behemoths that have never since been equaled.

The Egyptian pyramids started small, and in just a few generations, some 4,500 years ago, there came Khufus enormous pyramid, which nobody has ever tried to surpass. Shipbuilders in ancient Greece kept on expanding the size of their oared vessels until they built, during the third century BCE, a tessarakonteres, with 4,000 oarsmen. That vessel was too heavy, too ponderous, and therefore a naval failure. And architect Filippo Brunelleschis vast cupola for Florences Cathedral of Santa Maria del Fiore, built without scaffolding and finished in 1436, was never replicated.

The modern era has no shortage of such obvious overshoots. The boom in oil consumption following the Second World War led to ever-larger oil tankers, with sizes rising from 50,000 to 100,000 and 250,000 deadweight tonnes (dwt). Seven tankers exceeded 500,000 dwt, but their lives were short, and nobody has built a million-dwt tanker. Technically, it would have been possible, but such a ship would not fit through the Suez or Panama canals, and its draft would limit its operation to just a few ports.

The economy-class-only configuration of the Airbus A380 airliner was certified to carry up to 853 passengers, but it has not been a success. In 2021, just 16 years after it entered service, the last plane was delivered, a very truncated lifespan. Compare it with the hardly puny Boeing 747, which will see its final delivery in 2022, 53 years after the planes first flight, an almost human longevity. Clearly, the 747 was the right-sized record-breaker.

Of course, the most infamous overshoot of all airplane designs was Howard Hughess H-4 Hercules, dubbed the Spruce Goose, the largest plane ever made out of wood. It had a wingspan of nearly 100 meters, and it was propelled by eight reciprocating engines, but it became airborne only once, for less than a minute, on 2 November 1947, with Hughes himself at the controls.

Another right-size giant is Fords heavy and powerful F-150, now in its 14th generation: In the United States, it has been the bestselling pickup since 1977 and the best-selling vehicle since 1981. In contrast, the Hummer, a civilian version of a military assault vehicle, had a brief career but is now being resurrected in an even heavier electric version: The largest version using an internal combustion engine, the H1, weighed nearly 3.5 tonnes, the electric Hummer, 4.1 tonnes. I doubt we will see 14 generations of this beast.

But these lessons of excess carry little weight with designers and promoters pursuing record sizes. Architects discuss buildings taller than a mile, cruise ship designers have already packed nearly 7,000 people into a single vessel (Symphony of the Seas, built 2018) and people are dreaming about much larger floating cities (perfect for spreading the next pandemic virus). There are engineers who think that we will soon have wind turbines whose more than 200-meter diameter blades will fold, like palm fronds, in hurricanes.

Depending on where you stand you might see all of this either as an admirable quest for new horizons (a quintessential human striving) or irrational and wasteful overreach (a quintessential human hubris).

This article appears in the January 2022 print issue as Extreme Designs.

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Gigantism Is a Never-Ending Temptation for Engineers and Designers - IEEE Spectrum

The plight of Tamils of Indian origin in Sri Lanka – The New Indian Express

In a highly commendable move, the Rajapaksa brothers, who hold the reins of power in Sri Lanka, invited the UN Human Rights Council dealing with contemporary forms of slavery to visit Sri Lanka, study the living conditions of the most exploited sections of society like people working in garment firms in export promotion zones, tea plantation workers and migrants. Sri Lanka is the first country in South Asia to take this imaginative initiative. Will other countries in the region emulate the Sri Lankan example?Tomoya Obokata, UN Special Rapporteur, visited Sri Lanka between November 26 and December 3 for an on-the-spot study of the problems and met a cross section of workers, government officials, trade union leaders and NGOs involved in the subject. The rapporteur presented the preliminary findings in a meeting held on November 26. The final report would be submitted to the UN in September 2022.The workers in the tea plantations are of Indian Tamil origin. Apply any yardstickper capita income, living conditions, longevity of life, educational attainments and status of womenthey are at the bottom of the ladder. The UN Special Rapporteur has highlighted: Contemporary forms of slavery have an ethnic dimension. In particular, Malaiyaha Tamilswho were brought from India to work in the plantation sector 200 years agocontinue to face multiple forms of discrimination based on their origin. In 2017, Sri Lanka celebrated the 150th anniversary of its tea industry. The government and the planters organised a number of seminars and conferences to highlight the role of the tea industry in the economy, how to increase production in the sector and how to modernise it. The Institute of Social Development in Kandy was the only organisation that convened a seminar on those who produce the Two leaves and a Bud (novel written by Dr Mulk Raj Anand) that brings cheer early in the morning to millions across the world.The contrasting lives of the planters and workers should be highlighted. Given below are two quotations that describe the contrast. The BBC, in 2005, telecast a documentary titled How the British Reinvented Slavery. The documentary portrays the lives of the planters as follows: You can sit in your veranda, and sip the lemonade and be fanned by a servant and have your toenails cut at the same time by some coolie, and you can watch your labourers working, you could sleep with any woman you wanted, more or less everything was done for you from the time you wake up and the time you went to bed. People looked after you, people obeyed you, people are afraid of you, your single word as a plantation owner could deny life.Vanachirahu, a young poet from Malaiyaham, gave expression to the innermost feelings of his people in times of communal troubles. In a poem titled Dawn, the poet writes: Our nights are uncertain, dear, let us look at each other, before we go to bed. This may be our last meaningful moment. Finally press your lips on the cheeks of our children. Then let us think about our relatives for a moment. Lastly let us wipe our own tears.The most important feature of the Malaiyaha Tamils is the sharp decline in their population. At the time of independence in 1948, they were more in number than Sri Lankan Tamils. Because of the two agreements signed in 1964 and 1974 between Colombo and New Delhi, and repatriation of a large number of people as Indian citizens, their number declined. Today, according to census statistics, they number only 5.5% of the population.For the first few decades after independence, the major problem confronting the Indian Tamil population was the issue of statelessness. With a judicious mix of parliamentary and extra-parliamentary struggles, the community, under the leadership of Savumiamoorthy Thondaman, was able to extract citizenship rights from a recalcitrant Sinhalese-dominated government. All those born in Sri Lanka after October 1964 were granted citizenship, which also included the residue of the Sirimavo-Shastri pact, yet to be repatriated to India. With the introduction of the proportional system of representation under the 1978 Republican Constitution, the community was able to send more representatives to Parliament.The community is now engaged in a struggle for equality and dignity. The living conditions are improving but much more remains to be done before they can enjoy the status of perfect equality. First and foremost, human rights violations continue to take place. Though the political parties representing the Malaiyaha Tamils never subscribed to the demand for a separate state, they were subjected to vicious and savage attacks by lumpen sections of Sinhalese in 1977, 1981 and 1983. I happened to be in Hatton after the Bindunewa massacre in 2006. Indira, a young lady, confided that she was scared to move around Hatton because of insecurity. She contrasted that to her life with her brother in Perambur, Chennai, where she could go without any fear for late-night film shows. Second, the tea workers daily wage is around 1,000 Sri Lankan rupees, which is not even sufficient to meet their daily needs. Many, therefore, absent themselves from the plantations and go to work in vegetable farms where they are able to get double the wages, in addition to breakfast and lunch. Finally, while every boy and girl goes to school, there are many dropouts. Very few enter the university level. I was associated with the University of Peradeniya as a SAARC Professor for International Relations in 2006. In the final-year BA class, in Tamil medium, there were 10 students, of whom eight were Muslim girls, a boy was from Batticaloa and a girl from the plantation area. In the same year, the number of teachers from the Indian Tamil community in the university was less than 10.In his plan of action for three years, Sri Lankan High Commissioner Milinda Moragoda has highlighted that there should be more educational exchanges between the two countries. For instance, the Chennai Centre for Global Studies is very keen to step into the scene and assist the Tamil children, especially from the hill country, to come to India for secondary and college education, and is prepared to meet all their expenditures and also offer them scholarships. The community can come up only if they have good value-based education. Tamil Nadu can play a benign role in this direction.The transformation from Thottakattan (barbarian from the plantations), a contemptuous term used by Jaffna Vellalars, to the noble appellation Malaiyaha Tamil is an illustration of the qualitative change that has taken place in the hill country. But much more remains to be done before they become equal citizens enjoying equality of opportunity. Let me conclude with a poem written by M A Nuhman whom I had the privilege to know at the University of Peradeniya: Where there is no equality, there is no peace, where there is no peace, there is no freedom, these are my last words, equality, peace and freedom.

V SuryanarayanSenior professor (retd), Centre for South and Southeast Asian Studies, University of Madras(The author was the Founding Director of the Centre in the University of Madras)(suryageeth@gmail.com)

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The plight of Tamils of Indian origin in Sri Lanka - The New Indian Express

Big Review Confirms Power of Fasting Diets for Weight Loss – HealthDay News

TUESDAY, Dec. 21, 2021 (HealthDay News) -- Intermittent fasting is all the rage due to its potential health benefits, and now a new review shows this style of eating really does produce weight loss and may even improve certain markers of heart health.

Intermittent fasting is an umbrella term for several diets that alternate between feasts and fasts. The 5:2 diet involves eating normally five days of the week and restricting your calories on the other two days. Alternate-day fasting calls for a fast day-feast day-fast day pattern. In contrast, time-restricted eating refers to eating only during specific time windows each day.

"The new study demonstrates that the different forms of intermittent fasting, i.e., alternate-day fasting, the 5:2 diet and time-restricted feeding, are all effective weight loss interventions for people with obesity," said study author Krista Varady, director of the Human Nutrition Research Unit at the University of Illinois, in Chicago.

"Intermittent fasting may be an effective means of lowering heart disease risk by decreasing blood pressure, low-density lipoprotein [LDL] or 'bad' cholesterol, and triglycerides," she said. What's more, these diets may help prevent type 2 diabetes by lowering insulin resistance and fasting insulin levels.

Most of these benefits likely stem from weight loss.

"All of these regimens induce a calorie restriction of 15% to 30% daily, which results in weight loss," Varady said. "When an obese person loses weight, they almost always see reductions in LDL cholesterol, triglycerides, blood pressure and insulin resistance."

For the review, the researchers analyzed 11 studies that comprised 130 trials of various intermittent fasting regimens. When the investigators looked at all of the studies as a whole, intermittent fasting did produce weight loss and improvements in risk factors for heart health. However, only alternate-day fasting and the 5:2 diet resulted in a clinically significant weight loss of more than 5%, the study showed.

The findings were published online Dec. 17 in JAMA Network Open.

So, should you or shouldn't you jump on the intermittent fasting bandwagon, and if you do, which method is right for you?

Two experts who were not involved with the study agreed that it's too early to make any blanket recommendations.

"The study provides strong evidence that some, but not all, of the regimens result in weight loss and related decreases in body mass metrics and improvements in cardiometabolic risk factors, such as cholesterol levels, blood pressure and measures of insulin resistance," said Benjamin Horne. He is the director of cardiovascular and genetic epidemiology at the Intermountain Heart Institute in Salt Lake City, Utah.

The methods in this study that showed the most profound benefits tend to be the most difficult to follow, he noted. "Future studies should evaluate the ability of the average person to adhere to these regimens, because it is unclear that they are sustainable over the long term," Horne said.

The study also could not address if intermittent fasting reduces heart attacks or strokes or extends longevity. "It is unknown whether the average person can adhere to any of the four intermittent fasting regimens for a long enough period of time [years or decades] to affect those outcomes," Horne added.

And importantly, he asked, can weight loss can be sustained without continuing the regimen?

There are also safety considerations. "The hype surrounding intermittent fasting may be leading to harms to unsuspecting people who want to achieve better health," Horne explained, "especially people with diagnosed chronic diseases and asymptomatic health conditions."

New York City dietician Robin Foroutan isn't a fan of the difficult-to-stick-with intermittent fasting regimens that showed the greatest benefits in this study.

"I only recommend time-restricted eating and fasting-mimicking diets," said Foroutan. Fasting-mimicking diets work by tricking your body into thinking that you're fasting even though you're still eating. These methods are easier to follow so people are more likely to stay the course.

The bottom line? Always talk to your doctor before starting a new eating regimen, she said.

More information

The Academy of Nutrition and Dietetics has more on the various types of intermittent fasting.

SOURCES: Krista Varady, PhD, professor, nutrition, and director, Human Nutrition Research Unit, University of Illinois, Chicago; Robin Foroutan, MS, RDN, dietitian, New York City; Benjamin Horne, PhD, director, cardiovascular and genetic epidemiology, Intermountain Heart Institute, Salt Lake City, Utah; JAMA Network Open, Dec. 17, 2021, online

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Big Review Confirms Power of Fasting Diets for Weight Loss - HealthDay News

Crypto experts break-down their 2022 industry predictions – Yahoo Finance

As the final presents are bought and wrapped, and the sherry begins to flow, one question is hot on the tongue of families world-wide this festive season: When will you put down your phone and stop checking crypto?

Little do they understand the woes of a turbulent month of bearish Bitcoin divergence, nor do they understand the endless possibilities of what could happen next only one thing is certain its Christmas and its time to enjoy it.

In the festive spirit, Coin Rivet has compiled a barometer reading of experts crypto market sentiments for 2022 so you dont have to this holiday season.

For many of the experts, Web 3.0 has been veritably left out this year, although the significance of the sub-sector will continue to grow into 2022. Web 3.0 is focused on extending user utility in a decentralised capacity, and naturally this will place users as the central focus within the emergent technology.

Julian Sawyer, CEO of Bitstamp the worlds longest-standing crypto exchange, was keen to assert the viewpoint that customer interaction is a vitally human component of high tech systems.

In crypto especially, we use tech to drive our products and our business, however, our customer service is a space where we can be human, he explained.

The technical jargon in our industry is what causes customers to get confused or frustrated and we strive to be a place where people can enter the market with confidence.

In 2022, the focus should be on innovating products that provide a better customer experience, not to use the technology to separate potential customers out. As more people talk about metaverses, cyborgs and alternative realities, Im betting that people are going to want to talk to real people.

And Matt Zhang, the Founder of Hivemind Capital (a $1.5bn crypto fund built on the back of Algorand), concurs with this opinion adding the decentralised autonomous organisations (DAOs) will revolutionise user engagement in the future of industry, and the tech sector will be first.

Story continues

In 2022, we will see more companies explore alternative governance models using DAO and blockchain technology, highlighted Zhang.

This trend will be particularly obvious in the consumer tech sector, where consumers feedback on products shapes the longevity of the companies that provide those services in the first place.

Many have been quick to label 2021 as the year of institutional crypto adoption, however, the experts seem to suggest this moment is far from over amid economic concerns and the current state of adoption.

Diogo Monica, President of Anchorage Digital the first federally chartered crypto bank, explained how institutional adoption of crypto represented a generational wealth transfer that is evidenced by a maturing multi-asset class industry.

Its no longer just speculative investing in Bitcoin or Ethereum; were talking about NFTs, DeFi, remittances, capital preservation, and many other verticals, explained Diogo.

Well also see Bitcoin continue to act as a hedge against inflation, which continues to be important as rates rise.

Finally, banks and fintechs will continue to add support for crypto services across the board, as 2021 has shown us that the massive transfer of wealth to the millennial generation is well under way, and their needs are much different than their predecessors.

And Matthew Gould, CEO of Unstoppable Domains, a leading NFT domain name platform, highlighted how the standout performance of stablecoins in 2021 demonstrated the genuine utility of crypto to individuals and banks alike.

Stablecoins had a breakout year in 2021, reaching a market cap of over $152 billion. I predict that by 2024, the total market cap of stablecoins will reach $1 trillion, said Gould.

The biggest thing thats going to win over crypto skeptics is utility, and stablecoins are the best example of this stablecoins represent everything good about crypto without the speculation or the FOMO aspect, especially when you look at regulated stablecoins like USDC.

Kosala Hemachandra, the CEO of MyEtherWallet, believes that 2022 will deliver a new wave of NFT hype as the real use-cases finally emerge and come to fruition.

In 2022, Im looking forward to physical items such as car titles and house deeds becoming NFTs, said Hemachandra.

This will introduce a whole new game to crypto. NFTs are easy to understand, similar to collectibles in the real world.

Every wave of NFTs brings something new to the table, which means we havent even seen the full glory of NFTs yet.

Speaking to the metaverse, Colin Pape (Founder of Presearch), argued 2022 would be a battleground year that would see centralised entities and decentralised networks duke out ownership of online interactions.

Our collective shift towards the metaverse will continue to accelerate. This raises major concerns about privacy, explained Pape.

Its not just your Facebook account, its a shift to everything being online. Centralised companies like Facebook, Google, and Amazon will vie for control over our digital lives, so we need to focus on building a future that is a net positive.

The best way to do this is by offering alternatives to big tech platforms. As we shift towards a future in the metaverse, we should prioritise decentralised, open-source platforms, and educate people on alternatives to the centralised big tech platforms they use every day.

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Crypto experts break-down their 2022 industry predictions - Yahoo Finance

What was the Mossad director thinking? – Haaretz

Here is what Mossad director David Barnea said: Iran will never have nuclear weapons not in the coming years, and not ever. This is my pledge; this is the Mossads pledge.

I couldnt believe my ears. I wanted to see it with my own eyes. A video of this official event shows the president lighting Hanukkah candles, the prime minister spouting historical nonsense and the Mossad director spouting clichs. But the sentence quoted above nothing. Its disappeared.

Presumably it was left on the cutting room floor in the hopes it would be forgotten. Nevertheless, theres no doubt the Mossad chief said what he did, and his comments deserve to be discussed.

First, the Mossad director needs to grasp a painful truth he doesnt decide anything. Not whether Iran will have nuclear weapons, and not whether Iran wont have nuclear weapons. Because what can you do, the Mossad director only belongs to the servant class, not the decision-making class. And like all service providers (including secret services), the Mossad director is authorized to do only what hes told to do.

Heres an incident from the past that proves the point. Some decades ago, the heads of the secret services were ordered to assist the (evil) secret services of Irans then-ruler by providing equipment and training. And of course, they obeyed.

And thats what will happen in the future as well. If any Mossad director, including the current one, is again asked to help an Iranian tyrant (perhaps because of his support for the settlements or something like that), he too will obey. After all, thats the essence of his job obedience. Perhaps not blind obedience, but definitely squinting obedience.

Moving on, the Mossad director also declared that his pledge was forever. Thats a bit presumptuous, isnt it? Especially coming from someone whose term will end in another five and a half years at most.

His lifespan to everyones great regret, of course also isnt eternal. In just another 55 years, hell turn 120. And that, as everyone knows, is the upper limit God set for human longevity, according to Jewish tradition.

But its still permissible to hope that the world will go on for a few years after that. Therefore, the Mossad directors personal pledge that Iran will never have a nuclear bomb is about as coherent and impressive as a personal pledge by his Iranian counterpart that Israel will never have a nuclear bomb.

Moreover, the Mossad is undoubtedly an efficient assassination enterprise, and assassinations are very good for the ego, morale and the enthusiastic media. But they dont produce any real benefits. The Mossad also has a successful dirty tricks department that knows how to plant viruses in electric razors, disrupt the timetables of cable cars and even cause centrifuges to spin out of control. This department, too, is good at tactical annoyances but fails to produce any strategic benefits.

By contrast, the Mossad and its ilk around the world have been consistent failures for many years at anything connected to actual intelligence and strategic analysis. As proof, consider the collapse of the Soviet bloc, the fall of the Berlin Wall, the Yom Kippur War, the first intifada, the Iraq war, the attack on the Twin Towers, the war in Afghanistan and more and more and more resounding, embarrassing strategic failures that have escaped my gaze. But the top-secret operations are all really terrific.

Therefore, the Mossad director should try to enhance the functioning of his modesty gland and practice lowering his nose in front of a mirror. That might help him later on.

In his defense, I will say one thing only. His remarks were so arrogant, conceited, aggressive and inflated that together they create a frighteningly accurate reflection of Israel in 2021 arrogant, conceited, aggressive and inflated. And for that, he has my thanks.

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What was the Mossad director thinking? - Haaretz

The grandmother hypothesis: How humankind owes its success to matriarchs – EL PAS in English

The worlds great civilizations were forged contrary to family instinct. The Chinese created an objective system to select civil servants who would put the states interests above those of their families; the Christian world prohibited marriage among its clergy with similar intent and the Ottomans set up an administrative elite made up of foreign slaves who could not pass on the privileges they acquired during their lives to their children. All of this was designed to limit the impulse to put family interests above general ones.

However, these measures had limited success. There were archbishops who fathered children and the Ottoman Janissaries eventually reversed the prohibition on passing power to offspring. Family always wins out, perhaps because the famiy instinct is so ingrained in human nature.

Children hold incredible potential, but for it to be developed they require a prolonged and intensive care that frequently their parents are unable to meet. We are dependent for many years after birth and it is likely that this has encouraged some typical traits in the species. Recently, the journal of the Proceedings of the National Academy of Sciences of the United States of America (PNAS) published a study carried out by Harvard University researchers that suggested that active grandparenting favored humans maintaining physical fitness long after their prime reproductive years and that also explained why exercise is so beneficial in later life. This role of grandparents as the pillars of parenting could be the reason why women, contrary to what occurs in practically every other animal species, can live for decades after losing their reproductive ability.

The success of species at large is reproductive, but ours achieved success with an increase in non-reproductive time

The grandmother hypothesis was developed through the study of older female members of the Hadza people of northern Tanzania. Kristen Hawkes, of the University of Utah, observed that these women were extremely active in gathering food that they then shared with their daughters. This generosity was conducive to them being given more grandchildren. Years later, an analysis of pre-industrial societies in Canada and Finland reached similar conclusions. At the beginning of the 17th century in Quebec, ecclesiastical records made it possible to determine that women who lived in the same parish as their mothers on average had 1.75 more children than their sisters who lived further away. In Finland, the results showed a similar tendency, as long as the grandmother was not over the age of 75.

Natural selection would have favored longevity in species made up of dependent individuals, says Mara Martinn Torres, director of the Spanish National Center for Research on Human Evolution (Cenieh). Fragile human babies and their huge brains would have had more chance of survival and development thanks to their grandmothers and in turn their efforts would have given our species the reward of a much longer and healthier life span than that of our close relatives, such as chimpanzees. These animals, which remain fertile their whole lives, suffer serious physical decline in their 30s and rarely make it to 40.

The paleoanthropologist Marina Lozano notes that it is estimated this essential function in grandmothers began with Homo erectus, a species that emerged around 1.8 million years ago. It is the first species of our genus to have a similar structure and life cycle to ours, with a more dilated growth in which lactation and childhood are separated and we have another stage, adolescence, says Lozano, of the Catalan Institute of Human Paleoecology and Social Evolution.

It is probable that grandmotherly help began with human species that predated our own, but it seems that around 50,000 years ago cultural transformations occurred that intensified the phenomenon. According to calculations by Central Michigan University researcher Rachel Caspari, based on the fossilized teeth of 768 individuals who lived over the past three million years, among Homo sapiens during the Upper Paleolithic, the number of individuals surviving until an age when they could become grandparents was greatly increased. In that period, for every 10 Neanderthals who died between the ages of 15 and 30, only four lived longer. Among Homo sapiens, that number rose to 20.

Sapiens had already been on the planet for tens of thousands of years, but around 60,000 years ago something happened that increased their capabilities. There is a palpable cultural sophistication; it is the age when hybridization with Neanderthals took place and it also when there was a migration out of Africa that coincided with migrations within the continent, says Antonio Rosas, director of the Paleoanthropology Department at the National Museum of Natural Sciences in Madrid. This period was unique, something was happening and it is clear that it was changing social and cultural organization, something that would also change the value of grandparenting.

This capacity for cultural adaptation increased life expectancy among Homo sapiens, leading to larger numbers of grandparents in the population. Women are born with a number of egg cells that are distributed during their fertile years. On increasing life expectancy, there may have been a change that also increased the number of egg cells to maintain fertility for longer, but the presence of grandmothers without their own children to look after offered other advantages. Human females are among the few animal species that cannot reproduce until the end of their lives. The others are cetaceans with teeth, such as pilot whales, beluga whales, narwhals and orcas, which also have large brains.

During that period of reinforcing cultural and biological transformation, greater life expectancy would have been a driving force for the species, which after many millennia of survival was on its way to an unprecedented global expansion. Increased life expectancy allows for an overlapping of generations that makes it possible to accumulate exceptional wealth. The Australopiths never knew their grandparents. Being able to bring together three generations in one home is a hive of knowledge that other species do not have. Humans do not have to start from zero with every generation. That completely alters the value of older people, says Martinn Torres.

These societies, in which grandparents gained more and more importance, were responsible for artistic creations such as the cave paintings at Altamira in Spain and Lascaux in France. They were able to improve their hunting techniques and survived and prospered during the Ice Age in Europe, during which the Neanderthals disappeared. This peculiar species, that had been so fragile for so long, achieved its success in an almost paradoxical way, says Martinn Torres. The success of species at large is reproductive, but ours achieved success with an increase in non-reproductive time.

The developmental needs of the brain, the organ where intelligence resides, but above all the social skills of humans, changed other traits of human biology that at the same time reinforced cultural changes that transformed the planet. The childcare input of grandparents was one of the traits that defined human singularity. As on other occasions, the strength of the species was to be found among some of its weakest members.

English version by Rob Train.

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The grandmother hypothesis: How humankind owes its success to matriarchs - EL PAS in English

Longevity and Anti-Senescence Therapy Market 2021 Size, Status and Global Outlook Acorda Therapeutics, Calico Life Sciences, Human Longevity Inc.,…

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Why ‘Sunny’ is the greatest sitcom of all time – The Bona Venture

BY TUCKER REILLY, MANAGING EDITOR

Last week, the FX sitcom Its Always Sunny in Philadelphia premiered its 15th season, officially marking it as the longest running live-action sitcom in US history. The secret to the series longevity lies in its strong cast of characters, clever dialogue and constant boundary-pushing humor, which has allowed Sunny to garner an ever-increasing cult audience over nearly two decades. Additionally, the show has continued to produce quality content throughout its entire run, not suffering from the late season fatigue of many other sitcoms. With its unique comedic genius and historical precedent, Its Always Sunny should be considered the greatest American sitcom of all time.

Like many sitcoms, Sunny is based on a simple premise: five friends run a bar in Philadelphia, concocting schemes and settling scores with the local population. Unlike its thematic predecessor Cheers however, Sunny endeavors from the start to prove that its core cast are the absolute worst people imaginable. In the second season alone, our core five make a fake terrorist threat video, get addicted to crack cocaine, solicit bribes from local politicians and start a deadly Vietnamese gambling ring in the basement, among other crimes. The genius of Sunny lies in this darkness, in showing the viewer each characters rock bottom, then revealing that rock bottom is actually a cliff. Often the world around them acts as a universal straight man to the gangs antics, although Sunny does occasionally relish in finding someone even crazier than its own characters.

One of the defining features of Sunnys longevity is the shows acceptance of change, in contrast to the sitcom norm of status quo. When Dennis (Glenn Howerton) and Dee (Kaitlin Olson) get addicted to crack cocaine or suffer heart attacks (on separate occasions), they remain encumbered with these problems, although the culmination of their sins make each but a single aspect of chaos within the overall storm. Frank Reynolds (Danny DeVito) enters the series as a disciplined, business-savvy father figure to the group, who gradually devolves into a near-animalistic train wreck of a human being over time. Characters have children, gain and lose dramatic amounts of weight, suffer permanent afflictions and occasionally die. Sunny understands that its characters are not a mere collection of gimmicks, however, and molds its comedy around the irreplaceable actors themselves.

Its Always Sunny is an inherently character-driven comedy that mercilessly lambasts and pities its characters in equal measure. Many episodes of the show function like car wrecks, locking viewers into the sordid spectacle, while acknowledging the human flaws at each characters center. And more often than not, there is something profound there: we are not these people, yet we understand where their fears, desires and insecurities come from before they are turned up to 11. We want to see them win or better themselves but crave the inevitable implosion of their despicable actions. The snowball rolls on, keeping us firmly stuck within an ever-expanding web of degeneracy.

It is also important to emphasize the exceptional talent brought to Its Always Sunny by the cast and writing staff, who happen to be one in the same. The series core group of Rob McElhenney (the shows creator), Charlie Day, Kaitlin Olson, Glenn Howerton and Danny DeVito have built larger-than-life characters around their own strengths and eccentricities, sharply refined over time. The casts familiarity, mixed with Sunnys trademark rapid-fire dialogue, have allowed them to make nearly every scenario comedically valuable, while pushing the boundaries of the show to new heights. A key factor in this development has been creative freedom: due to the shows relatively low profile on FX, McElhenney and co. have been allowed to stretch the series into strange new directions largely without restriction. While some creative decisions such as the shows ironic use of blackface have been poorly received, Sunny has never lacked nuance in its satire. Its Always Sunny is a unique and terrible creation developed by a singular set of people, consistently sustaining itself for over 15 years (even though we all know seasons five through nine are the best, of course). It deserves, without a doubt, a seat at the table as the greatest American sitcom of all time.

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Why 'Sunny' is the greatest sitcom of all time - The Bona Venture

Where Is the Endgame in Chess Experts’ Visual Memory Abilities? – University of Texas at Dallas

Chess experts are known for their remarkable ability to recall configurations of chess pieces on a board. For decades, neurological experts have investigated how this memory functions and whether it can be applied to information beyond the gameboard.

To further probe this topic, researchers from The University of Texas at Dallas Center for Vital Longevity (CVL) turned to the UTDallas chess team. Since the chess programs inception in 1996, 24 Grandmasters and International Masters have played for the UTDallas team, which has competed in the Presidents Cup known as the Final Four of College Chess in 17 of the last 21 seasons.

Dr. Chandramallika Basak

The researchers tested 14 chess team members, along with 15 chess novices, on rapid-fire processing of visuospatial information in working memory.

Their findings, published June 14 in Memory and Cognition, help pinpoint the strengths and limitations of the subjects recall framework and how that framework can be applied to human cognition in general.

Prior studies have shown that chess experts advantage in visual memory is limited to chess pieces on chess boards, said corresponding author Dr. Chandramallika Basak, associate professor of psychology in the School of Behavioral and Brain Sciences. We wanted to see whether the expertise generalizes beyond chess pieces to unfamiliar, new stimuli, and where does this expertise break down for immediate memory.

Chess masters visual short-term memory for arrangements that can occur in chess has been of particular interest to cognitive scientists, said Basak, director of the Lifespan Neuroscience and Cognition Laboratory.

Its almost like chess experts have snapshots of these positions they demonstrate remarkable visuospatial working memory, given that the information is presented for less than half a second, she said. But is it driven by the visual aspects or spatial aspects of what they saw? Or a combination of both?

Evan T. Smith, a UTDallas cognition and neuroscience doctoral student, is the papers lead author. He described the difference between working and long-term memory as analogous to the gap between whats on top of your desk and whats filed away in a cabinet.

Evan T. Smith

The existing theory is that chess players have so thoroughly memorized and categorized board configurations that their long-term memory for this information functions like working memory, he said.

The researchers collaborated with Jim Stallings, director of the UTDallas chess program, to bring test subjects on board from the team.

Dr. Basaks study varies from other chess studies done with youngsters, Stallings said. This study goes directly to chess expertise and working memory. I look forward to sharing the results with the chess community.

The control group included UTDallas students of similar age and education level to the chess players who had never formally learned how to play chess.

In each test, participants saw a two-dimensional chessboard with a number of pieces displayed for three-tenths of a second. After a one-second pause, they saw a second chessboard and had to decide if there had been a change.

The tests were conducted with standard chess pieces and with novel, unfamiliar symbols. Basak said that this switch helped to determine if the chess players memory abilities were domain specific to chess or domain general to a wider range of objects.

One series of tests asks about changes in location; the second asks if the objects the pieces themselves have changed, Basak said. A third test incorporates changes in location or changes in object, or both, or no change at all. Finally, the grid of the board is removed.

The researchers found that while both chess experts and novices performed better with chess stimuli than with the unfamiliar symbols, the experts, for the most part, outperformed the control group for both chess stimuli and for the new objects particularly when detecting positional changes.

Section A of this figure from the Memory and Cognition article shows how each trial works: An initial configuration appears for three-tenths of a second, followed by a one-second pause. The three different trial types then could change an objects identity, location, or both. Section B shows the chess stimuli and novel stimuli used. Section C shows a trial with the grid removed.

When changing the identity of the objects, however, but not location, the chess players advantage was limited to the chess pieces. They performed no better than the control group at remembering when the identity of the novel symbols changed.

You would expect that this advantage that chess players have is related to a familiarity with the chess pieces or the chess players expectation of what they are about to see, Basak said. But results from our study say otherwise. It seems like the chess players can rapidly process a chessboard-like layout in a very holistic manner, like the brain does with faces. The next step in our research may be to do a functional MRI study to see if the face-processing regions of the brain are also used for chess.

The experiments also were split into tests using fewer than four pieces which is within the normal limits of an average persons focus of attention and five to eight pieces. With the larger number of pieces, long-term memory should come into play. The chess experts performed better than the controls in the tests with more pieces.

We observed an eight-item working-memory capacity for chess experts, Basak said. We assume that ties back to the idea that chess players are viewing the board and the set of positions as a single object, as they would recognize a face.

The grid-versus-no-grid portion of the study something that Basak said has not been examined before produced some of the more striking results.

The grid is the linchpin that supports the scaffolding of this memory structure, Smith said.

Basak added: Any expertise-related advantage disappeared in the absence of the chessboard display. It appears to be essential, acting as a road map, a familiar framework to aid the memory.

Collectively, the results indicate that visuospatial memory advantages associated with chess expertise extend beyond chess stimuli in certain circumstances, particularly to position changes with between five to eight items. But the grid appears to be necessary for experts to leverage these advantages.

We cannot generalize our findings beyond what we tested, so we cannot claim, based on our data, that chess experts will be better at studying for school, Basak said. But their advantage does go beyond chess pieces, provided the grid remains. We believe this indicates that experts are automatically encoding spatial-relational information.

Other contributors to the research were Dr. Daniel Krawczyk, UT Dallas professor of psychology, holder of the Debbie and Jim Francis Chair in Behavioral and Brain Sciences, deputy director of the Center for BrainHealth and associate professor of psychiatry at UT Southwestern Medical Center; and Dr. James Bartlett, a distinguished scholar in cognitive neuroscience and cognitive psychology and a longtime UTDallas faculty member who played a key role in the beginning of the project. Bartlett died in 2019.

Jim Bartlett played a big role in designing the experiments and in bringing Jim Stallings and the chess team on board, Basak said. He was a mentor, friend and valued collaborator, and we dedicate this publication in honor of his memory.

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Where Is the Endgame in Chess Experts' Visual Memory Abilities? - University of Texas at Dallas

Watson professor named ASME fellow for three decades of electronics packaging innovations | Binghamton News – Binghamton University

Moores Law packing twice as many transistors on the silicon every 18 months has driven our technological revolution over the past 50 years. The processing power that once took entire buildings of computer banks now fits into the palm of your hand, giving smartphones access to all the knowledge of the internet.

In the past few years, though, as semiconductor manufacturers are making circuits measured in single nanometers, Moores Law appears to be coming to an end. (For scale, 1 nanometer is a billionth of a meter, smaller than a strand of human DNA.)

To accommodate consumer expectations for even smaller and powerful devices, researchers are increasingly looking to electronics packaging a term that encompasses everything apart from the chips themselves. The field always has been important to ensure the proper functioning and longevity of devices, but now it is more critical than ever.

Professor SB Park a faculty member in the Thomas J. Watson College of Engineering and Applied Sciences Department of Mechanical Engineering has researched electronics packaging for nearly 30 years. As the director of Binghamton Universitys Integrated Electronics Engineering Center (IEEC), he and his team have made key discoveries that improve how everyday devices work.

In appreciation for his groundbreaking research and contributions, the American Society of Mechanical Engineers (ASME) recently named Park a fellow of the organization, which includes more than 90,000 members in 135 countries worldwide. Only about 3% of members become fellows.

ASMEs fellow grade is the highest elected grade of membership within ASME, said ASME President Mahantesh Hiremath. It recognizes exceptional engineering achievements and contributions to the engineering profession.

Park said he is honored by the recognition and hopes that it brings more attention to the research being done at Watson College.

It is a meaningful recognition, and also a way of promoting my ideas and my Universitys division to the wider world, he said. To be promoted to fellow, you have to proactively reach out to the technical communities by organizing conferences and symposiums, and by promoting a certain technology or bringing more attention to a certain field.

Park earned his BS and MS from Seoul National University in his native Korea, and his PhD at Purdue University. Before coming to Binghamton in 2002, he worked on electronics packaging for seven years at IBM Corp.s Microelectronics Division, but he originally had a very different career path in mind.

When they approached me and offered the job as a packaging engineer, I knew what IBM was but because I was an aerospace engineer, I didnt have any clue why they would need me. Is IBM packaging chocolate cake or something? he thought.

In fact, they were doing something very similar, trying to protect electronics from drop shock and packing more into each device without ruining the electronics by the heat generated internally. I studied fracture and failure in aircraft, and they recognized that my background and expertise could effectively contribute to solving the problems they faced.

Although he works in academia now, Park believes the experience and knowledge he acquired during his time in industry has been vital to the success of IEEC, his colleagues and students. Many others on his IEEC team have similar experiences working at tech firms.

About 70% of my research groups projects are associated with industry, and we have weekly meetings with the sponsoring companies, he said. All of my graduate students are directly connected with industry on a weekly basis. It is not just theoretical engineering it is real engineering as they work toward their dissertations. They know the industry languages and what the hot topics are at their companies, which could be their future employers.

To explain the challenges that electronics packaging faces, Park makes an analogy to an automobile: When you build a car with a powerful engine, such as a 500-horsepower engine, you need stronger axles to handle that strain, a top-notch steering system that keeps you on the road and excellent brakes that will stop the car before a collision. Similarly, as silicon chips get smaller and powerful, the accessories that help it to maintain its level of performance must also shrink and be resilient.

Much like an urban area with a growing population occupying a finite amount of space, one way to make everything fit is to start thinking three-dimensionally, but stacking components faces one big problem: How to dissipate the heat buildup?

Heat is the biggest threat for any electronics, Park said. When creating a three-dimensional design, how do we take the heat out? For the topmost component, we can use conventional methods, but what about the middle ones? Its going to be well cooked in the middle!

Finding solutions for future generations of electronics is a daunting mandate to fulfill, but Park is always looking ahead and eager for what comes next.

Every day, the research is fun, and that is making me busy with joy, he said. Im really grateful to be having this opportunity in my life.

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Watson professor named ASME fellow for three decades of electronics packaging innovations | Binghamton News - Binghamton University

Turn Biotechnologies Expands the Potential of its mRNA Platform by Licensing Unique Artificial Niche Technology – PRNewswire

MOUNTAIN VIEW, Calif., Feb. 3, 2021 /PRNewswire/ --Turn Biotechnologies, a company developing medicines for currently untreatable age-related conditions, announced that it has acquired the global rights for new artificial niche (AN) technology that can be used to restore muscle stem cells damaged by aging.

The company licensed its AN technology from Stanford University, where it was developed by a researcher who serves as an advisor to Turn. AN technology is used to create a microenvironment that maintains stem cells in a quiescent state to repair or replace specific types of damaged tissue. The stem cell niche provides structural and trophic support and the appropriate homeostasis to regulate stem cell function.

Turn will use the niche technology in combination with its mRNA-based epigenetic reprogramming of age (ERA) technology to restore specific cells' youthful functionality, to trigger the body's ability to fight age-related diseases.

"Our artificial niche technology expands the applicability of our ERA technology to a variety of diseases involving tissue that requires a microenvironment to maintain cell quiescence," said Anja Krammer, Turn CEO. "By enveloping our ERA technology in the protective matrix of an artificial niche, we can reactivate muscle stem cells, as well as stem cells in tissues where quiescence is necessary to maintain stem cell functions."

The combined use of Turn's AN and ERA technologies may be able to restore function in hematopoietic, liver, brain, certain mesenchymal stem cells across different tissues and within the hair follicle.

This is Turn's second licensing announcement since the start of the year. Earlier, the company revealed that it acquired the global rights for its ERA technology from Stanford University, where it was developed by three researchers who founded Turn. It is the first technology to maintain cellular identity while restoring specific cells' youthful functionality, to trigger the body's ability to fight age-related diseases.

As with ERA, the company announced that it has filed for patents to protect its AN technology in major-market nations on six continents.

"This is significant for our pipeline because the combination of AN with our ERA technology in murine models shows increased potency," said Jay Sarkar, Turn's chief technology officer and a company founder who helped to develop the ERA technology. "The studies show that aged muscle stem cells treated with this combination therapy fully regenerate age-related muscle dysfunctions."

Turn's technology uses messenger RNA to produce instructions that induce cells to treat or prevent disease. Use of mRNA, which led to the quick development of two COVID-19 vaccines, promises to revolutionize the development of therapeutics by making that development safer, faster, more efficient and extremely tunable to patient need.

Turn is currently completing pre-clinical research on tailored therapies targeting indications in dermatology, ophthalmology, osteo-arthritis and cartilage damage and musculature.

ABOUT TURN BIOTECHNOLOGIES

Turn is a pre-clinical-stage company focused on repairing tissue at the cellular level. Our proprietary mRNA technology combats the effects of aging in the epigenome, thus restoring optimal gene expression and enabling cells to function as vigorously as when they were younger. Our technology provides a platform from which to attack a variety of diseases related to age. The company has the financial backing of Methuselah Fund, which focuses its investments to extend the healthy human lifespan; Formic Ventures, which invests in biotech start-ups focused on human longevity; and Shanda Group, a private global investment firm. For more information, see http://www.turn.bio.

FOR MORE INFORMATION, CONTACT:Jim Martinez, rightstorygroup[emailprotected] or (312) 543-9026

SOURCE Turn Biotechnologies

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Turn Biotechnologies Expands the Potential of its mRNA Platform by Licensing Unique Artificial Niche Technology - PRNewswire

Nagy: The president and the tsar – LubbockOnline.com

TIBOR NAGY| Lubbock Avalanche-Journal

Churchill had some brilliant quotes, but his most famous one about Russia a riddle wrapped in a mystery inside an enigma. -- is wrong. Russias self-identified role in the world hasnt been a mystery since Napoleons wars, maybe even earlier: to protect its heartland by extending its control and influence as far as possible in every direction, and to perpetuate the privileges of its ruling class thru all possible means.

Through expansion under a succession of Tsars and Commissars the Russian landmass now covers 11 time zones and exerts influence much farther. While Russias vastness and bitter winters consistently defeated a series of enemies who had no problems overrunning the rest of Europe, its leaders have been less consistent in their capabilities. But its current tsar, President Vladimir Putin, is also one of its ablest understanding fully how to maximize Russias weakened global position. With the end of the Soviet Union in 1991, Russia lost about 25% of its territory, and as recently as 2009 was characterized as Burkina Faso with nuclear arms (meaning its economy relied on the export of natural resources).

But while Putin may be holding a pair of tens, hes playing them like a full house. Added to his mastery of history and geopolitics is his expertise in human behavior gleaned from decades of KGB tradecraft which makes him doubly dangerous as an adversary. He has a near perfect record of opportunistic timing on when/how to strike with calculated impunity: seizing Crimea, saving Assad in Syria, sending combat volunteers into eastern Ukraine, manipulating Western Europe to embrace his Nordstream II natural gas pipeline, winking at cybercriminals who inflict major damage on U.S. infrastructure and morale, and poisoning political opponents when he cant simply arrest and torture them.

But for once, going into a summit with a Russian leader, the U.S. side was represented by a president who himself has long political experience and doesnt suffer from naivete or geopolitical ignorance. The U.S. track record in these meetings has been poor: e.g. Roosevelt giving away Eastern Europe to Stalin and Kennedy coming off so weak to Khrushchev that the Soviets were emboldened to move nuclear missiles to Cuba. (Reagan being an exception who more than held his own against Gorbachev.) There will be thousands of words written analyzing the Biden/Putin Summit, but they matter little. What counts is what measure Putin took away from their meeting because that will determine how Putin will play his pair of tens during Bidens presidency.

Putin will stay as he has - searching for and exploiting whatever weaknesses he detects in the US leadership or the western alliance. He will use every geopolitical weapon he believes he can get away with, pursue the Big Lie as effectively as any Soviet leader ever did, neutralize his opponents with whatever means work, and continue to allow his cronies to amass immense wealth at the expense of his people. Russia is neither a mystery, riddle nor enigma. Russia will simply continue its centuries-long policy of opportunistically and brutally assuring its place in the world and the longevity of its ruling class.

Ambassador Tibor Nagy was most recently Assistant Secretary of State for Africa after serving as Texas Techs Vice Provost for International Affairs and a 30-year career as a US Diplomat.

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Nagy: The president and the tsar - LubbockOnline.com

5 Ways To Stay Younger And More Creative As You Get Older – Forbes

5 ways to develop a younger mindset

There is a fountain of youth: it is your mind, your talents, the creativity you bring to your life and the lives of people you love. When you learn to tap this source, you will truly have defeated age - Sophia Loren

With life expectancy steadily rising in most countries around the world, the number of people aged sixty-five years or older will rise sharply over the next two decades. And you might already be one of them.

Certainly, were already seeing far more centenarians and near-centenarians than ever before. Just a few weeks ago, the world was collectively awed by nonagenarian William Shatners trip to space as the worlds foray into space. Not long after, there were numerous news stories about Dr. Manfred Steiner earning his third doctorate at the age of 89. But there are hardly outliers. More than ever, we are seeing other examples of seniors in their eighties and beyond continuing to enrich the world with their achievements instead of settling into the decrepit old age far too many people pessimistically see in their own future.

But what is it that makes these super seniors so vibrant and active? Though it is easy to attribute this ability to stay young to good genes alone, the opposite seems to be the case. A ground-breaking Danish study published in 1995 examined more than 2500 twin pairs born between 19870 and 1900 and concluded that genetics only played a modest role (at best) in human longevity. Instead, non-genetic factors, including lifestyle choices and environmental stress appear far more important in determining how long people can remain active and healthy over time.

Perhaps as importantly, the attitudes that people have towards growing older are often shaped by the kind of negative stereotypes too many of us have. These stereotypes often result from cultural expectations as well as the experiences people have dealing with their aging parents and grandparents. Along with affecting how people treat older adults, these stereotypes can also make us pessimistic about our own aging and what we will be capable of as we grow older. According to Stereotype Embodiment Theory,

people who internalize their own negative beliefs about aging are more prone to physical and mental health problems as well as becoming less productive as they age. A conclusion borne out by recent research.

This can include the belief that we are somehow doomed to become less creative and, presumably, less productive with time. Granted, this point remains controversial with many physicists, computer scientists, musicians, and even artists doing their most prominent work before they hit midlife (or younger). And yet, there are prominent exceptions: J.R. Tolkien was 62 when he wrote the first volume of the Lord of the Rings, prominent physicist Sir William Crookes was 68 when he began cutting-edge research into radioactivity, while Bertrand Russells work as a writer, academician, and peace activist continued until he was almost 100.

And this is just the tip of the iceberg when you consider that people over the age of 65 represent the fastest growing age group internationally, largely due to the major medical advances of the past few decades. As I have noted in prior articles, the biological limits of our own lifespans are being radically altered and new breakthroughs may push the upper limits of human longevity even further in decades to come.

But, there is more to aging than taking stock of your grey hairs and wrinkles. Along with physical aging, there is also psychological aging, something I have already covered previously on Forbes. Also known as subjective aging, our own research has demonstrated that a lower psychological age is linked to better mental and physical health. While true physical rejuvenation isnt available (at least so far), it is also possible to make yourself feel younger, something that is an important feature of successful aging. Here are just a few suggestions you can try, and you are welcome to come up with your own suggestions:

Set ambitious longevity goals for yourself, along with fosterity the optimism you will need to achieve these goals. Our research into using deep learning techniques to predict human psychological and subjective age shows that people who are more optimistic about the future of their health and longevity, expect to live to the age that is substantially longer than average in their country, and of their health and expect to stay in good health or even improve in the next 10 years and beyond. But, what might happen if you imagined yourself living to 120 years or longer and spending those extra years being healthy and productive? Even if medical technology fails to give you those added years, the positive mindset this optimism will produce can have valuable benefits in its own right.

Science is not standing still. Huge progress was made in science and technology in the past decade alone and you should expect to live much longer and healthier. Learn as much as you can about the recent progress in aging research and tart making your own plans for an extended future. Some books you can start with include popular non-fiction books like David Sinclair's Lifespan: Why We Ageand Why We Don't Have To,

Peter Diamandis's books, The Future Is Faster Than You Think, and Bold. You can also take a look at Sergey Young's book The Science and Technology of Growing Young. These are just a few of the books already available on what is already a hot topic in science and many more will become available soon enough.

Take a psychological aging test and try to develop a longevity mindset. Go to young.ai and register for the app which can also be downloaded onto your Android or iPhone. By answering a few simple questions about your medical history and syncing information from your medical tests or your FitBit or Apple Watch, you can receive age estimates based on your different measures. This includes estimates of lifestyle age based on your response to health survey questions, mind age based on your psychological survey responses, or blood and heart age based on biomedical data. There is even a photo age feature estimating age based on face appearance alone! Use the data the app provides to develop an action plan for staying younger.

Develop friendships with younger people and avoid the retirement peer pressure that might motivate you to act your age and just settle for a comfortable retirement. As I noted in previous articles, humans are very good at adapting to radical changes, whether positive or negative. This hedonic treadmill can also cause many older adults to become complacent about their lives and correspondingly less flexible in terms of handling changes and the stress that comes with it. This means that the best way to stay younger and more creative is to avoid this age trap and take yourself out of your comfort zone. At least once in a while.

Consider taking a few courses or even going for an entire degree at a university that requires group work and constant interaction with the younger people.

Join or start a new business, preferably in health or longevity. New business opportunities are springing up daily and this is a trend that can only go upwards in the years to come. Instead of focusing on retirement, you can think of new business opportunities for yourself. Many of these opportunities will stem from the growing number of over-65s living longer and more active lives. Start exercising your own creativity and plan out a business model that will revitalize your own life.

These are just a few suggestions to consider and you can likely come up with more with the right determination and a little creativity. Remember the words of Mark Strand who said that the future is always beginning now and start planning out your own future. It will be here faster than you think.

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5 Ways To Stay Younger And More Creative As You Get Older - Forbes

What Is The Most Vegan Way To Die? Welcome To A Human Compost Funeral Home – Green Queen Media

While its not the most pleasant of subjects to discuss, most people may be surprised to learn that traditional burials are fairly toxic and harmful to the environment. As such, there has been an increase in individuals around the world looking for innovative ways to die in a manner that will be kinder to the planet. A new US company is looking to serve this market. As described in Recompose is the first full-service human-composting funeral home, providing an ecological solution for your remains when you die which involves turning you into soil.

Recompose has opened its doors to the public with its first full-service human-composting funeral home that will convert people into soil, after almost a decade of research, planning and raising funds as well as a campaign to change state law.

Founded by Katrina Spade, the first bodies were laid in Recompose starting on December 20, 2020, after a 10-year extensive journey. An architecture student at the University of Massachusetts at Amherst, Spade first looked into funeral alternatives whilst enduring a minor mortality crisis of her own. Through her research, she found that when it came to traditional burials, options were extremely limited, and most were toxic and/or expensive. Cremations tend to be carbon-intensive, while rural green burials are rare and inconvenient for urban folks.

Spade went on to explore the method of composting as a kind of soil-based cremation, leading her to complete her masters thesis on the subject. Of Dirt and Decomposition: Proposing a Place for the Urban Dead was published in 2013.

This is a very controlled process, completely driven by microbes. Its fueled by plant material and monitored in a very rigorous way

The Recompose process takes around 30 days, starting in a vessel that consists of wood chips and straw. After a few weeks, the process continues in curing bins, large boxes, one per individual, where the soil will rest and continue to exhale carbon dioxide. After the completion of this process, the family of the individual can either collect the soil or donate it to an ecological restoration project at Bells Mountain near Vancouver, Washington. So far, most families have chosen to donate the soil.

As Spade explains, each vessel is supervised for temperature and moisture content with the help of sensors that note temperature readings every 10 minutes. This ensures that the microbes inside are receiving what they require for safe and efficient composting along with rotating each vessel a few times during the process as all compost needs turning.

State regulations state that the soil must maintain a temperature of 131 degrees Fahrenheit for 72 hours that helps to safely cook away pathogens like fecal coliform and salmonella. The state also asked Recompose as well as a third party to test for those pathogens along with heavy metals, including arsenic, lead and mercury in the final soil. Furthermore, the state restricts people who have contracted certain diseases such as tuberculosis, prion infections like Creutzfeldt-Jakob disease, from undergoing natural organic reduction (NOR).

Spade adds that the process is entirely controlled. It is also completely driven by microbes. Its fueled by plant material and monitored in a very rigorous way.

In the first couple of months of Recompose, Carpenter-Boggs, a soil scientist from WSU, was present to keep a watch on the soil along with guiding Spade and her team to care for the deceased. Sade mentioned that before each body is laid into its vessel, Carpenter-Boggs requests those present to take a moment and she then recites a poem by the 13th-century Sufi poet Rumi.

Another vital component of the process is the oxygen, with air being blown into each vessel via one set of tubes and through the other set, exhaust is released passing through carbon-activated filters.

Steve Van Slyke, compliance director for the Puget Sound Clean Air Agency mentioned that the emissions and odors from NOR are expected to be minimal with respect to other operations they review. These include cremations, demolitions of asbestos-filled buildings as well as marijuana cultivation. Recomposes air permit does not show any visible emissions from the facility, nor detectible odors.

Carpenter-Boggs shared that her founder journey has involved a steep learning curve. I dont come from the funeral-care world at all and Ive learned a lot over the past five or six years.

At one point in January, eight deceased people were already inside the vessels with the process of NOR, in simple terms, human composting underway. The vessels contained remains from Ernest Ernie Brooks II, an underwater photographer to organic-farming pioneer Robert Amigo Bob Cantisano to Paulie Bontrager, a vegan, environmentalist, and nature lover from West Virginia who passed away while visiting her daughter.

Charlotte Bontrager, Paulies daughter, told the Seattle Times that she had come across a newspaper article regarding Recompose a couple of years ago. I discussed it with my mom. We talked about how cool it was and why it took so long to get a service like this. I remember her saying: If its at all possible when I die, I want to go that way. Longevity runs in my family, her uncle died a year ago at 104, and I said: Oh mom, youll be around another 30 years. Im sure itll be in place by then.

Two years after this conversation, her mother was diagnosed with a previously undetected lung condition. At that time, Bontrager wasnt thinking much about disposition choices until her mother passed. Bontrager then remembered the conversation they had and on research, discovered that Recompose was ready. My mom was a very humble, loving person and would not want any kind of spotlight. But shed be thrilled to know she was among this first group of pioneers.

As Ive learned more about Recompose, Ive found it to be a very graceful and beautiful way to go. Its the natural way, the way every living thing in history has eventually been cared for, from an apple core to a human youre not being burned up, not being pumped full of embalming chemicals and taking up space in a container. It seems like a peaceful way for the body to move on to the next phase

To get Recompose to an operational stage, another significant challenge was to push for a change in state law allowing NOR to be a legal means of disposition for human remains and this turned out successful with Governor Jay Inslee signing off on it back in May 2019. The company also raised US$6.75 million in capital, enabling them to get started with their service.

Recompose charges an all-inclusive US$5,500 fee, which includes the body pickup service that is available in King, Pierce, and Snohomish counties, the paperwork, the process as well as body transport from further away can be arranged, for an extra fee, with Recompose accepting bodies from California and the East Coast.

Bontrager added that as she learned more about Recompose, she found it to be a very graceful and beautiful way to go. Its the natural way, the way every living thing in history has eventually been cared for, from an apple core to a human youre not being burned up, not being pumped full of embalming chemicals and taking up space in a container. It seems like a peaceful way for the body to move on to the next phase.

In 2020, two other NOR competitors have come about: Herland Forest, natural-burial cemetery in Klickitat County with one vessel, also called cradle and Return Home, that is slated to open its Auburn facility in April.

With the emergence of these NOR funeral homes, more and more individuals now have the option to opt for a peaceful ecological burial that will help the planet and even in death make sure that they dont unnecessarily contribute to climate change. Lets hope human remains composting becomes more mainstream and more such burial centres open across the globe.

Lead image courtesy of Recompose.

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What Is The Most Vegan Way To Die? Welcome To A Human Compost Funeral Home - Green Queen Media

Launch a new you with the new year – Houston Chronicle

Q: I really want next year to be the year I become as healthy as possible. Can you help me figure out a plan and schedule?

Casey R., Santa Rosa, Calif.

A: Bravo! You are planning ahead and making a public declaration of your intention to live a healthier and happier life! That shows how serious you are about achieving your goals.

By following the lifestyle adjustments suggested in my book What to Eat When and the longevity-extending tips in The Great Age Reboot (due out in 2022), you can put together a plan that is both easy to follow and loaded with great rewards.

The What to Eat When formula says eat only when the sun is up: a window of approximately 12 hours, depending on the time of year. This allows for a resting period (or fasting) and can help you break the habit of bingeing on snacks.

The guide also suggests you eat most of your food for breakfast and lunch. Aim to consume 80 percent of your daily calories before 3 p.m.

As for what you eat during these recommended times: You know the drill: plant-based, free of added sugars, no red or processed meats and no ultraprocessed foods.

Move it to lose it and gain a longer, healthier life. In The Great Age Reboot, I list steps you can take to self-engineer your fitness.

Walk 10,000 steps a day or the equivalent one minute of activity equals about 100 steps.

Get two or three sessions of strength training a week include core-strengtheners to avoid back problems down the road.

Do cardio exercise that increases your heart rate three times a week for 20 minutes. Aim for 80 percent of your age-adjusted heart rate (figure it by subtracting your age from 220 and then taking 80 percent of that).

Take 40 jumps in place a day. This increases lymphatic flow, bone density and spine health.

Q: Cancer seems to run in my family, and I want to do everything I can to help prevent it from happening to me. Can you tell me about cancer-fighting foods?

John Y., Indianapolis

A: You are right to fight! Genetic predispositions do not always mean you are going to develop whatever condition they are affiliated with. Your lifestyle choices can activate that predisposition or help squelch it! And food is a powerful tool when it comes to helping prevent cancer.

Some of our favorites are berries, lentils, kale, spinach, cauliflower, 100 percent whole grains and turmeric.

Berries: Blueberries, blackberries, raspberries and strawberries contain phytochemicals such as anthocyanins and a powerful antioxidant, pterostilbene, that reduce chronic bodywide inflammation (from obesity, red meats, added sugars, stress and poor sleep habits). Chronic inflammation ups the risk of cancer substantially. Berries also contain something called ellagic acid; laboratory studies show it has antiviral, antibacterial, antioxidant and cancer-preventive properties.

Lentils: High-fiber foods nurture good gut bacteria and may reduce the risk of colon cancer. They also help control appetite and weight being overweight is associated with an increased risk of 12 cancers.

Kale, cauliflower and spinach: Kale and other cruciferous veggies, like broccoli, cabbage and cauliflower, contain glucosinolate, which can cause tumor cells to die. Spinach contains carotenoids that may help fight cancer. It also has glycoglycerolipids certain formulations may inhibit some forms of breast cancer.

Whole grains: They contain fiber, phytochemicals and minerals that help fight cancer. One metastudy looked at the diets of 786,000 people and found that eating 7 grams of whole grains daily was associated with a 20 percent decrease in the risk of dying from cancer.

Turmeric: This tasty spice may do more than add flavor to your favorite foods. Laboratory and animal research indicates it may prevent cancer, slow its spread, make chemotherapy more effective and protect healthy cells from damage by radiation therapy. Confirmation in high-quality human trials is needed.

Contact Dr. Roizen at sharecare.com.

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Launch a new you with the new year - Houston Chronicle

Aiming to make 70 the new 50, Korify rolls out $100M longevity and mental health venture fund – FierceBiotech

Longevity and mental health biotechs take note: Korify Capital is putting together a $100 million venture fund targeting your space and is looking to build a portfolio of 15 to 20 companies across Europe, the U.S. and Israel.

The targeted $100 million investment vehicle, which is expected to close around the middle of next year, is the first fund of Korify, the international venture arm of Swiss family office Infinitas Capital. Infinitas is active in multiple areas outside of biotech, notably real estate, but has been tracking advances in aging and mental health research and has decided the time is right to enter the space.

There are a lot of opportunities coming from academia. We have made a lot of progress in research that is now hopefully about to get translated into human applications in the coming years, and we've made great progress on the animal front and can actually do quite a lot. They're already prolonging lifespan, Robin Lauber, co-founder and chairman of Infinitas, said.

Lauber and Davide Ottolini, co-founder of Korify, each identify COVID-19 as an accelerant, both because it has increased the interest of generalist investors in longevity and because it could spur innovation in the historically moribund mental health sector. With large biopharma companies pulling back from central nervous system research, Korify sees room for smaller biotechs to build on academic progress, creating investment opportunities for the new VC fund.

RELATED: Cambrian snags $100M for 14 assets, 3-5 trials within 18 months

Theres not like a couple of dominant companies that just own the space, Lauber said. Rather, there's a lot of disruption happening at the smaller scale, in smaller biotech companies, that are very lucrative to invest in and very interesting from an investor's perspective.

Korify plans to invest in 15 to 20 such biotechs, with a focus on later-stage platform companies. That focus is evident in Korifys decision to make Cambrian Biopharma its first investment. Cambrian, which exited stealth in February, has disclosed $160 million in financing this year to advance a pipeline of 14 drug candidates designed to target biological drivers of aging.

We like their approach of being very diversified, with multiple shots on multiple targets, Lauber said. They also are very aware of the current regulatory systems that are in place. We don't really have any solid longevity biomarkers, so their strategy is set up in a way that they can get there with the current FDA framework.

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Aiming to make 70 the new 50, Korify rolls out $100M longevity and mental health venture fund - FierceBiotech

Rally Cycling rebrands as Human Powered Health – Canadian Cycling Magazine

Building on 15 years of bringing the best of North American cycling to a global audience, Circuit Sport announced on Monday a new vision of what a racing team can stand for. The new team will be known as Human Powered Health.

Human Powered Health will be a wellness platform built to empower people to take control of their own physical and mental well-being. It will spread the message that cultivating healthier habits and living a more active lifestyle can lead to dramatic improvements in health and wellness.

Human Powered Health represents more than racing, more than athletics, said Charles Aaron, managing director and founder of Circuit Sport. Its about reminding people that they have more power over their health than they think. We want to support people, mind and body, and use our platform to inspire them to take small, simple steps towards greater health and well-being.

In previous iterations of its teams, Circuit Sport has continually gone beyond the traditional sports marketing model with health and wellness-minded campaigns like Inspired Bikes, Body Positivity, Healthy Habits, and Longevity.That will expand and evolve as the Human Powered Health platform grows into a hub for health and wellness content with its athletes as the main mouthpiece. New brand partnerships will allow the team to incorporate data analytics across sleep, nutrition, movement, and health care to support its followers on their health journey.

The team will also launch a Discord channel that will serve as a hub for fans, partners and clients interested in all things Human Powered Health. Hosted by the team and with regular appearances by professional riders, the channel will be a place to share ideas on how to live healthier lifestyles.

Human Powered Health joins the Womens WorldTour in 2022. It is the realization of a dream that began 10 years ago with the formation of the womens program. The move makes Human Powered Health the first co-ed team to send its women to the top division of the sport before its men.

Following a sensational season that included victories in the United Kingdom, Portugal, Denmark, France, and Turkey, the mens program continues in the ProTeam ranks with its sights set firmly on the WorldTour.

Rally Cyclings Sara Poidevin challenges you to create healthy habits

We couldnt take this step without the support of our partners and their shared vision for the future, added Aaron. Weve shown our ability to win bike races around the world but what sustains us is creating connections and empowering people.

Circuit Sport is currently aligning with brands that stand for something bigger than their product, a vital step to building the foundation of Human Powered Health for years to come. These brands, which will be announced in the coming weeks, share the belief that our collective health matters.

In a world navigating a pandemic, and where obesity and heart disease are at all-time highs, there has never been a more important time for each of us to invest in our health and inspire those around us to do the same. Building connections and sharing encouragement and knowledge are pivotal to empowering people to lead healthier lives.

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Rally Cycling rebrands as Human Powered Health - Canadian Cycling Magazine