How CRISPR can help us win the fight against the pandemic – MedCity News

Covid-19 has changed life as we know it. It has also accelerated already rapid trends in innovation and collaboration across the scientific community.

As the pandemic spreads across the globe, researchers are racing to develop diagnostics, vaccines and treatments. In the pursuit of new solutions to tackle SARS-CoV-2, the novel coronavirus that causes Covid-19, researchers have been turning to machine learning, AI and high-throughput experimental automation that aid in development. Another powerful tool they are using to accelerate the process is CRISPR. This gene-targeting and gene-editing technology, based on the mechanism that bacteria naturally use to fight viruses, is already proving useful in our joint fight against this new virus.

CRISPR Advances Covid-19 TestingWe know early detection of SARS-CoV-2 is essential to isolating infected patients and managing appropriate healthcare responses. Recently, researchers at MIT published a rapid CRISPR-Cas13-based COVID-19 detection assay protocol.Since CRISPR can be modified to target nearly any genetic sequence, it can be used to detect SARS-CoV-2 RNA in a patient sample. This assay utilizes an RNA-targeting CRISPR nuclease to help scientists detect the SARS-CoV-2 RNA from patient samples within 60 minutes. More recently, an improved assay was developed by researchers at MIT that was shown to provide faster and more robust results.

Utilizing another CRISPR nuclease that is thermostable, they developed a test that in one step copies the viral RNA in a patient sample, such as saliva, into the more stable DNA and then specifically identifies a SARS-CoV-2 gene sequence. Performing this point-of-care assay requires minimal lab equipment and resources, as it only needs a few reagents and a heat source, delivering results in as little as 40 minutes. Supplementing existing tests with new CRISPR-based approaches can broaden accessibility to Covid-19 testing, a key strategy for stopping the spread through track and trace efforts, as outlined by the World Health Organization.

CRISPR Helps Engineer Future TreatmentsPreviously, the genome-engineering power of CRISPR has been directed at fighting genetic diseases. But more recently, its also being harnessed to fight infectious diseases, now including the new coronavirus.

Understanding how a pathogenic disease operates at the host-pathogen interface is critical to developing new treatments. CRISPR-based genome engineering enables researchers to study how SARS-CoV-2 interacts with human cells and generate the appropriate cell models that could lead to faster discovery of a potential new treatment or an existing drug combination that may provide a treatment solution. Once a potential treatment is identified, CRISPR makes the next step drug target screening more efficient, advancing us more quickly to a viable treatment option.

As an example of this approach in action, researchers are exploring if CRISPR can be used to verify the functional relevance of human genes recently identified to interact with SARS-CoV-2 proteins. The investigation of the molecular mechanisms of the novel virus can ultimately help identify drug combinations that have the best potential to treat those infected.

Current Fight for the Future of Human HealthGenome engineering has been rapidly harnessed by academic and non-profit institutions, the biopharma industry, and scientific pioneers to develop Covid-19 testing and treatment solutions. CRISPR-based genome engineering enables researchers to study how SARS-CoV-2 interacts with human cells and generate the appropriate cell models that could lead to faster discovery of a potential new treatment or an existing drug combination that may provide a treatment solution.

Beyond this, the unprecedented innovation taking place in response to the Covid-19 pandemic will provide a foundation for improving human health in the future. Additionally, as technologies and understanding mature, new approaches, such as engineered cell therapies, will become part of the toolkit in future responses to global health challenges.

The current scientific response is representative of the future of life sciences a future where we integrate multiple technologies and disciplines including high throughput experimental automation, machine learning and agile, programmable tools such as CRISPR to fundamentally change our approach to research and development. We are seeing a new bar being set on the speed of science as the research community comes together, leveraging these technologies to respond to the Covid-19 pandemic at unprecedented velocity. Once the public health crisis subsides and the research halted by the pandemic resumes, the need for these transformative tools, technologies and approaches to life science research and development will be greater than ever.

Photo: wildpixel, Getty Images

See the original post here:
How CRISPR can help us win the fight against the pandemic - MedCity News

The great research mouse rescue amid the pandemic – WHYY

This story is from The Pulse, a weekly health and science podcast.

Subscribe on Apple Podcasts, Stitcher or wherever you get your podcasts.

Back in mid-March, when most of us were hearing the words shelter in place for the first time, research labs across the country were busy with what they call sacking.

There are a lot of different terms that are used that I think people use to protect themselves from the reality of this, said Anneka Allman, a research technician at a University of Pennsylvania lab that works with hundreds of mice as part of cancer studies. Personally, I prefer to say we kill them, but the common term is sacking.

Sacking, because thats where the animals end up after theyre killed in a sack, in a freezer.

Research mice, you might imagine, generally are not long for this world. At her lab, Allman is usually the one to send them into the hereafter. Most of the mice born there even in normal times arent suitable for experiments for some reason or another so, straight to the sack.

Id say maybe we only actually use like a tenth of the mice that we breed, Allman said. Euthanizing these mice on a regular basis is just part of the job, and its not a fun part of the job, but it is a necessity.

Still, what happened back in March, on Friday the 13th, it was different it was a massacre.

We have a weekly lab meeting and we had it virtually, and we were like, OK, we need to figure out how to shut everything down she recalled.

They had some 500 cages of mice, and a looming stay-at-home order for most staff. You just cant take that many mice home with you, and many cant survive outside sterile settings. So most of the mice, they were going to get sacked.

It was just like piles and piles of cages just on top of each other empty cages, Allman said.

She personally euthanized hundreds of the mice.

Its actually very simple. You take their cages, take off the tops, put it in a machine called the Euthan-X which I have a lot of feelings about, but its essentially just a CO2 chamber, Allman said. And you turn the button on, and you wait for 20 minutes to half an hour, and they die.

Allman only worked that Friday before she was sent home for safety, but a skeleton crew stayed behind and sacking continued.

We did get an email about, I think, two weeks in that basically requested that we stop asking them to do it because of the emotional toll that it was having on them because of the masses that they had to kill, Allman said.

The animals deaths didnt hit her on that level. Before you get the wrong idea about Allman, know shes a self-described animal lover, a vegetarian; one of her pet cats scurried across her laptop during an interview. But she didnt mourn the euthanized mice, so much as the science the mice represented.

I had to kill mice that I had planned experiments for, that Im still upset theyre dead and not because of their lives, unfortunately for them, but because to do this research its going to be a lot. Its going to take a lot longer.

Untold thousands of mice were sacked in the early weeks of the United States pandemic response. The animals in Allmans lab, and in hundreds of labs like it, are the bedrock of research into human diseases.

Pick a disorder, an illness. Theres a mouse model for that, a mouse created specifically to study that disease.

Cat Lutz is director of the mouse repository at the Jackson Laboratory in Maine.

So whatever disease you can think of, you know, epilepsy, obesity, metabolic syndrome, anything that you can think of, we have a mouse model that you can genetically engineer to recapitulate that particular disease, Lutz said.

The Jackson Lab is a nonprofit where many labs get founder mice to start colonies of their own for research. It has about 11,000 strains of designer mice cryopreserved in its repository 80% of which dont exist anywhere else.

Mice first found their way into labs by way of so-called mouse fanciers.

They would keep mice as pets, and they would also select those mice that had spontaneous mutations, for example, coat color or ears or craniofacial features, long tails, kinky tails, maybe spotted mice or things like that, and they would start inbreeding them, Lutz said.

Mice breed very quickly and very often, so mutations tend to spring up fairly regularly. Fanciers were after aesthetic mutations, but scientists quickly found fanciers could provide mice with more utilitarian mutations. This mouse with a kinky tail, it can develop diabetes, or colon cancer, or this rare neurological disease.

Between mouse and humans, the gene conservation is incredibly high at the level of the coding sequence, so it was really quite translational, Lutz said.

Mice and people share about 98% of their genetic code.

The mutations that you would see in the mice would often translate to the mutations that you see in people, she said. They really have become the model animal for humans.

So if you can cure a cancer in a mouse, thats a step closer toward curing it in a person.

See the article here:
The great research mouse rescue amid the pandemic - WHYY

Science is dead, long live ‘Frankenstein science’ – stopthefud

Todays recognized facts in science are incomplete because they ignore spirit, will, and emotions. But more and more scientists have the courage to transfer knowledge from quantum physics and philosophy to everyday life. Dr. Ulrich Warnke explains how consciousness and subconscious mind control reality formation and shows how we activate these abilities in ourselves as it is written in many mystical texts. The key to a new world creation are certain states of consciousness that we can learn. This gives us effective tools to change our living conditions for the better. Source.

Ulrich Warnke (* 1945), photo, is a German biologist. He studied biology, physics, geography and pedagogy and received his doctorate in 1973. He taught as a senior academic at the Saarland University and has been retired since March 2010. One of his focal points is the effect of electromagnetic vibrations and fields, including light, on organisms. [Playlist with videos]

Wikipedia [which is a by a clan-like group of higher educated students, people, scientists, run, maintained and constantly updated website, where all info that does not fit within the mainstream [=wrong] concept of science is named pseudo-science or worse, and frequently even removed]: His statements on questions of the importance of quantum physics experiments are controversial. In his books he tries to correlate quantum physical experiments and results with spiritual experiences.

My comment: this sentence unveils that the author(s) of the Wikipedia article does/do not know by experience which spiritual experience is meant, or worse: that spiritual experiences are imaginations. Spirituality is real and not a belief or a religion, but a state of being as a part of the total existence, to be experienced in every day life, during work, in meditation and/or contemplation. An authentic spiritual experience cannot be acted. Kundalini is an authentic spiritual experience. There are explanations on the web what kundalini is, but the most are not correct. There are even people who pretend to be able to awaken this energy in others. It is not necessary to awaken it, not even healthy, because it has to develop in a totally natural way, and only then it occurs on the right moment. It is difficult to explain what it is. One can read about it to get an idea. The first time I saw the term kundalini was when I was reading an old book that I found in a library in the Netherlands, about yogi in India: those who practice yoga. That was in the seventies of the former century. My first experience with this energy dates from the end of the seventies and I did not know what exactly was happening, did not even remember what I had read about it. The experience is for everybody who undergoes it, different, but one recognizes it in what is written about it anyway.

Also Carl Gustav Jung had kundalini experiences and in his Red Book he is explaining the process of it, via texts and drawings, paintings. I prefer to name kundalini an evolutionary experience, instead of spiritual experience, though it is both, but I chose this to avoid silly remarks of those who do/did NOT experience it. One of the results of this process is a deeper sense for reality, wholeness, and oneself. Scientists are not, generally, aware of a wholeness, because they did NOT experience this, are evolutionary (far) back in the, in the meantime normal, human process of evolution especially in younger people and sometimes even children. That means that these scientists, who are still in the majority, show a lack of ethics, and absence of awareness, where also quantum physics work with. This has created the madness, the absolute chaos we live in, today. Science, as one could expect, does not exist any more, and IF, it is rejected as pseudo-science and ridiculed. They, who make themselves guilty of that, expose themselves as silly, ignorant, but are, logically, not even aware of that, because they belong somewhere in the lower degrees of the human evolution:

Spiritual Evolution

Reason for creating this blog article, is the tweet that I found coincidentally today, on May 14, 2020, and in which the subtitle of the website The World Foundation of Natural Science is ridiculed, because of the terms divine and the name of what we learned to categorize as saint: Francis of Assisi. One cannot find anything on the Wikipedia page, on not any page or website, that could categorize publications of a website that mentions the name of Francis of Assisi, to be based on conspiracy theories, as if the term spiritual, or divine, belongs to those who believe in something that does not exist: God. God does indeed not exist as a human-like being on a cloud and no I do not believe in a church, but I do believe in the church of nature, earth, Life, Universe, All Existence. That church is not a building where you can go in or out, but where one is constantly in, even if one does not realize it, or even denies it. Francis of Assisi is mentioned on the website of the World Foundation of Natural Sciences because of his view on nature and the environment. Very honourable. One cannot say that the one who tweets and writes about people in the way he is used to, is honourable. On the contrary. He is even creating conspiracy theories himself around a website that is not hiding its convictions and views on life and nature, and that is undeniable related with an unsolved problem in the persons own unconsciousness.

Another remarkable fact is, that the science as it has become, and where the Twitter professor is talking about as real science, is comparable with a church, a religion, and a real Pope. All laws are accepted as right and followed up, even mandated. The role of the Pope in science is performed by the industry, and this Popes College of Cardinals has the name ICNIRP. The Twitter professor has written lots of protest articles in his blog about the industry-popes College of Cardinals: ICNIRP. There are more priests (scientists) that oppose the rules of the Industry Pope, but several priests show to have the same ethics as those they say to oppose, as several of these rebellious priests show on Twitter: they even protect the College of Cardinals ICNIRP, retweet the ICNIRP Gospels and at the same time they write letters against ICNIRP on their website. Can you follow it? This group of dubious priests (scientists) are rejected world wide even in all newspapers, and named conspiracy theorists, or just named, and blown away with names of priests and cardinals that matter in and for the industry. The hard core scientists, the Frankenstein Scientists. That is the situation on this moment. The titles scientist, doctor and professor should be protected. The titles are used and abused by all kinds of humans and are not any guarantee for Truth. One can factually only expect Truth in those who respect spirit, spirituality, but just a few dare to speak about spirit, and spirituality.

The only reason that the Twitter professor was able to find the link to the newsletter of the World Foundation is this (my) blog, and I suspect him for being in this blog more often, as the stats of my blog show from which countries there have been searchings. I know where he lives. Why I suspect him of visiting my blog? Because of the facts that follow after. One of these is his tweet of today, about a newsletter that nobody else has shared, than me.

In the following excerpts, by Dr. Mae-Wan Ho , one can learn to understand more about science, real science. What has become out of what once was science and what has lost the most essential facets of what once was science. Mainstream science is not science, but a deformed clone of what once was science: Frankenstein science.

I found the name of Dr. Mae-Wan Ho in the newsletter of The World Foundation of Natural Science, the newsletter that has been ridiculed by the one who tweeted about it and who has marked it as based on conspiracy theories. He wants, he writes in the tweet, real science. Well. The newsletter contains 31 evidence based facts in t
he references. With other words: the so-called twitter professor, dressed in an oversized white blouse on his Twitter profile picture, is lying. To underline that: here is Dr. Mae-Wan Ho, with her view on real science.

.

The End of Bad Science and Beginning Again with Life (Excerpts)By: Dr. Mae-Wan Ho (1941-2016) Paragraph: The two-way connection between science and society

Genetic engineering biotechnology is not just about food production. It is about any and every way of exploiting life and our life-support system for profit. It is the ultimate in the dominant way of life that knows the monetary cost of everything and the value of nothing.17

There is a two-way connection between science and society. Science is both shaped by the politics and the mores of society and it can reinforce them. And nowhere is it more clearly seen in the mechanistic, instrumental worldview that pervades the scientific mainstream and the dominant culture at large.

The mechanistic paradigm of western science is really a direct legacy of the Judaeo-Christian tradition. The tradition inspired the search for eternal laws, ordained by God, which could make the universe move in predictable, mechanical ways. Through Copernicus, Galileo and Descartes, this strand of thought culminated in Newtons mathematical laws of mechanics. Mechanical explanations seem so compelling that every event in nature came to be seen in a mechanical perspective.

Another strand in the legacy of the Judaeo-Christian tradition is that human beings are supposed to be created in the image of God and to have immortal souls, while animals and the rest of nature are to be used by human beings. Descartes established the dualistic separation of human beings from nature, of mind from body and matter from spirit. He maintained that only human beings can reason, that animals are unfeeling machines; and condoned cruel experiments on dogs and cats. Francis Bacon, similarly, urged that it was our right to extend our power and dominion over the universe.18

Thomas Hobbes went further. For him, nothing exists except matter and motion, the universe including human being are to be explained mechanically. He argued that human beings are ruled purely by their appetites and aversions, and without a powerful king to restrain and channel those impulses, our lives would be poor, nasty, brutish and short. In other words, absolute government is necessary to prevent the war of each against all to which natural selfishness inevitably leads19. Hobbes was writing when mercantilism reached its high point in Europe, and brought great power to those princes and merchants who successfully accumulated vast quantities of gold and other precious metals.

Hobbes influence has passed down to us via Charles Darwin in an age that saw the birth of capitalism and the expansion of the free market under the military might of the British Empire. Nature became ultimately reduced to isolated atoms jostling and competing in the struggle for survival of the fittest. In its present-day form, neo-Darwinian sociobiology has changed very little from social Darwinism. Neo-liberal economic theory is in many ways much more pernicious than Adam Smiths laissez-faire economics, which is based on competition tempered by moral restraint20. And so, through the self-fulfilling prophecy, mechanistic science has created a dysfunctional social milieu and a globalized economy which is destroying our planet and failing to serve the physical and spiritual needs of the vast majority of humanity21. That was why fifty thousand people from all walks of life and of all ages took to the streets at the World Trade Organization conference in Seattle at the end of November, 1999.

It is clear that the mechanistic paradigm has failed the reality test in life as in science. But the discredited paradigm is still perpetrated by mainstream academic institutions as though no alternatives exist.

Paragraph: Frankenstein science

Mechanistic biology has reached its logical conclusion when organisms including human beings are to be genetically manipulated and cloned. The first human clone has been created, by injecting the genetic material of a human being into a cows egg22, a scene reminiscent of Mary Shelleys prophetic parable of Frankenstein.

Dr. Frankenstein, in a role not unlike the contemporary genetic engineer, is a scientist obsessed with mastery over nature; so much so that he attempts to create the perfect human being. Instead, he created a monster. Mary Shelleys classic is as much a parable of the mechanistic science that inspires the deed as it is of the scientist playing God.

All species are being genetically manipulated. Millions of transgenic mice are being created to serve as dubious models of human diseases, and an increasing number have to be sacrificed to make room for more. Livestock are humanized to provide spare organs for transplanting into human beings, or engineered and cloned as bioreactors to produce pharmaceuticals and industrial chemicals in their milk, blood, urine and semen, and with tens of thousands of failures and abnormalities.23

Apart from the potential hazards of creating new viruses that cross species barriers, the excessive suffering inflicted on the animals violates the most basic moral code of human society. Michael Fox strongly questions the right of human beings to interfere so profoundly with the inherent nature or telos of other species24. Indeed, each species has its own intrinsic value, its own purpose in the scheme of nature, which we violate at our own peril. This is also the most abiding ecological wisdom which western science has lost touch with, and is only now rediscovering.

Paragraph: The organic revolution and the new ethic of science

Genetic determinism offers a simplistic, reductionist description which is a travesty of the interdependence and complexity of organic reality. It has no concept of the organism as a whole, nor of societies or ecosystems. That is one reason why genetic engineering, at least in its current form, can never work. It is based on misconceptions that organisms are machines, and on a denial of the complexity and flexibility of the organic whole.

This brings us to the kind of science appropriate to society, which can transcend the existing dominant ethos, to support the necessary transition to sustainable ways of life, and to connect with the organic uprising that is coming from the grassroots all over the world. Many remarkable individuals and local communities are indeed changing their own lives and the world around them for the better. They all do so by learning from nature and recognizing that it is the symbiotic, mutualistic relationships which sustain ecosystems and make all life prosper, including the human beings who are active, sensitive participants in the ecosystem as a whole.25

The same organic revolution has been happening in western science over the past thirty years. Jim Lovelocks Gaia theory, for example, invites us to see the earth as one super-organism26. Even more remarkable is the message from quantum theory: that we may be inseparably entangled with one another and with all nature, which we participate in co-creating. In other words, the universe is an entangled whole consisting of organisms that are themselves wholes. From my own work, I have shown that the organism is so perfectly whole that it approaches quantum coherence: a state of both maximum local freedom and global cohesion27. The organisms activities are fully coordinated from the molecular to the macroscopic, and that is why, with a special imaging technique invented in my laboratory, we can see the living, moving organism as a liquid crystalline being.

It is this holistic, organic perspective that can enable us to negotiate our path to a sustainable future. It also provides the basis of a new ethic of science that can reshape society and transform the very texture and meaning of our lives. Seattle has shown us that things can be different. Society does not have to be ruled by the dominant culture. Science can
transcend the dominant status quo to reshape society for the public good, which is also the private good. We begin to appreciate how the purpose of each organism and species is entangled with that of every other. Our humanity is a function of this entangled whole, and we cannot do arbitrary violence to one another, nor to the nature of other species without violating our own nature.

.

References of the used excerpts:

17. See Ho, 1998, 1999 (note 2).18. See Fox, M. (1999). Beyond Evolution, Chapter 5, The Lyons Press, New York.19. See Korten, D.C. (1998). The Post-Corporate World, Life After Capitalism, Kumarian Press, West Hartford and Berett-Koehler Publishers, San Francisco.20. See Korten, 1998 (note 20).21. See Mander, J. and Goldsmith, E. (1996). The Case Against the Global Economy, And For a Turn Toward the Local, Sierra Club Books, San Francisco.22. Fears that a baby could be cloned Ian Cobain, Daily Mail, 17 June, 1999.23. See Ho, M.W. (2000). Towards a new ethic of science. In Ethical Careers Guide for Young Scientist, Scientist for Global Responsibility, London.24. Fox, 1999 (note 19).25. See Korten, 1998 (note 20); also, Hawken, P., Lovins, A. and Lovins, L.H. (1999). Natural Capitalism,26. Lovelock, J.E. (1988). The Ages of Gaia: A Biography of Our Living Earth, Norton, New York.27. Ho, M.W. (1993, 1998). The Rainbow and The Worm, The Physics of Organisms, World Scientific, Singapore.

Complete article.

Related article: How the fifth generation wireless standard 5G contributes to the corona pandemic

Like Loading...

Related

More here:
Science is dead, long live 'Frankenstein science' - stopthefud

Scientists Find New Way to Inject Plants With Medicine, And It May Help Save Our Crops – ScienceAlert

You may not think of plants as needing life-saving medicine, but that's sometimes the case when bugs and disease strike. Now, scientists have developed a super-accurate, highly delicate way of delivering drugs, and right where plants need them.

At the moment, plants can be sprayed with pesticides, which doesn't really penetrate to the roots, or they can be treated with large needles that aren't particularly precise, and tend to cause damage to the plants.

The new method makes use of microneedles or what the researchers are calling 'phytoinjectors', sitting on top of a silk-based biomaterial patch, which are able to hit a plant's circulatory system directly. Pesticides, in contrast, might travel between the root system and the leaves.

(Cao et al., Advanced Science, 2020)

As well as delivering medicine or nutrients to different parts of the plant, the new mechanism could also be used to take samples of a plant, which are then transferred to a lab for analysis, or even to edit DNA (something the team has successfully tried).

"We wanted to solve the technical problem of how you can have a precise access to the plant vasculature," says mechanical engineer Yunteng Caofrom MIT.

"You can think about delivering micronutrients, or you can think about delivering genes, to change the gene expression of the plant or to basically engineer a plant."

The motivation for the project came from the spread of the citrus greening disease across the US and other parts of the world, which threatens to flatten an industry worth $9 billion if a solution isn't found. Olives and bananas are other fruits under particular threat from disease across the world right now.

Previous work looking at the use of microneedles to deliver human vaccines was used as a starting point, with silk kept as the basis of the material holding the microneedles.

Silk is strong, doesn't cause a reaction in plants, and can be made degradable enough to get out of the way once the drugs have been delivered.

However, a lot also had to change compared to microneedles used on humans: plants have far less water available than the human body does, so the design had to be adapted.

The team of scientists was able to boost the silk's hydrophilicity (water-attracting capabilities), and come up with a new material more suited for plants.

"We found that adaptations of a material designed for drug delivery in humans to plants was not straightforward, due to differences not only in tissue vasculature, but also in fluid composition," says biologist Eugene Lim.

Tests of the material and its microneedled payload on tomato and tobacco plants showed that it could be successful as a drug delivery system. Fluorescent molecules were used to track the progress of the injection all the way from the roots to the leaves.

The system should adapt to other plants fairly easily, the researchers say, though scaling it up is going to prove more challenging. The work should prove useful for future projects though, both in delivering life-saving drugs to save plants from disease, and in engineering them to avoid disease in the first place.

"For the future, our research interests will go beyond antibiotic delivery to genetic engineering and point-of-care diagnostics based on metabolite sampling," says environmental engineer Benedetto Marelli.

The research has been published in Advanced Science.

The rest is here:
Scientists Find New Way to Inject Plants With Medicine, And It May Help Save Our Crops - ScienceAlert

The Pandemic and America’s Response to Future Bioweapons – War on the Rocks

In the fall of 2011, Dr. Ron Fouchier developed one of the most dangerous viruses you can make. Fouchier, a Dutch virologist at the Erasmus Medical Center in Rotterdam, claimed that his team had done something really, really stupid and mutated the hell out of H5N1.At nearly the same time, Dr. Yoshihiro Kawaoka at the University of Wisconsin-Madison worked on grafting the H5N1 spike gene onto 2009 H1N1 swine flu, creating another transmissible, virulent strain.

Despite only 600 human cases of the H5N1 (bird flu) virus in the previous two decades, the exceptionally high mortality rate greater than 50 percent pushed the National Science Advisory Board for Biosecurity to block the publication of both teams research. After a heated debate in the scientific community, the World Health Organization deemed it safe to publish the findings. While Kawaokas paper appeared in the journal Nature, Fouchiers original study appeared in Science. Although both teams generated viruses that were not as lethal as their wild forms, critics worried that the papers would enable rogue scientists to replicate the manipulations and weaponize a more contagious virus.

While some arms control experts like Graham Allison believe that terrorists are more likely to be able to obtain and use a biological weapon than a nuclear weapon, others have dismissed bioweapons due to dissemination issues, exemplified in failed biological attacks with botulinum toxin and anthrax by the terrorist group Aum Shinrikyo. Furthermore, studies from the U.S. Office of Technology Assessment indicated that bioweapons could cause tens of thousands of deaths under ideal environmental conditions but would not severely undermine critical infrastructure. In 2012, Dr. Anthony Fauci, the longtime director of the National Institute of Allergy and Infectious Diseases, argued that the benefits in vaccine advancement from Fouchiers research outweighed the risks of nefarious use.

Today, however, Fauci is at the helm of Americas response to a global pandemic. Although the world has never experienced a mass-casualty bioweapons incident, COVID-19 has caused sustained, strategic-level harm. In the absence of a vaccine, it has killed more than 60,000 Americans and forced over 30 million Americans into unemployment. The isolation of large segments of society has crippled the economy and traditional sources of American power: domestically, cascading, second- and third-order effects plague critical national infrastructure; and internationally, power projection wanes, epitomized by the U.S. Navys sidelining of the USS Theodore Roosevelt.

While the SARS-CoV-2 virus that causes COVID-19 is not a bioweapon, technological advances increase the possibility of a future bioweapon wreaking similar strategic havoc. Specifically, advancements in genetic engineering and delivery mechanisms may lead to the more lethal microorganisms and toxins and, consequently, the most dangerous pandemic yet. Therefore, the United States should develop a new strategy to deter and disrupt biological threats to the nation.

Engineering the Next Pandemic

Although a bioweapon-induced pandemic seems unlikely in the short term, preparedness for future attacks begins with understanding the possible threat. According to the Centers for Disease Control, bioweapons are intentionally released microorganisms bacteria, viruses, fungi or toxins, coupled with a delivery system, that cause disease or death in people, animals, or plants. In contrast to other chemical, biological, radiological, or nuclear weapons, they have distinctive dangerous characteristics: miniscule quantities even 10-8 milligrams per person can be lethal; the symptoms can have a delayed onset; and ensuing waves of infection can manifest beyond the original attack site. The Centers for Disease Control grouped over 30 weaponizable microorganisms and toxins into three threat categories based on lethality, transmissibility, and necessity for special public heath interventions. While Categories A and B cover existing high and moderate threats, respectively, Category C focuses on emerging pathogens, like the Nipah virus and hantavirus, that could be engineered for mass dissemination. Historically, though, bioweapons were relatively unsophisticated and inexpensive when compared to chemical and nuclear production chains, which explains their protracted use.

One of the earliest examples of biological warfare occurred over 2,000 years ago, when Assyrians infected enemy wells with rye ergot fungus. In 1763, the British army presented smallpox-infested blankets to Native American during the Siege of Fort Pitt. During World War II, the Japanese army poisoned over 1,000 water wells in Chinese villages to study typhus and cholera outbreaks. In 1984, the Rajneeshee cult contaminated salad bars in Oregon restaurants with Salmonella typhimurium, causing 751 cases of enteritis. Most recently, Bacillus anthracis spores sent in the U.S. postal system induced 22 cases of anthrax and five deaths in 2001, and three U.S. Senate office buildings shut down in February 2004 after the discovery of ricin in a mailroom.

Despite this history of usage, the challenge of disseminating the biological agent has, thus far, meant that bioweapons attacks have not produced high casualties. Bioweapons can be delivered in numerous ways: direct absorption or injection into the skin, inhalation of aerosol sprays, or via consumption of food and water. The most vulnerable and often most lethal point of entry is the lungs, but particles must fall within a restrictive size range of 1 micrometer to 5 micrometers to penetrate them. Fortunately, most biological agents break down quickly in the environment through exposure to heat, oxidation, and pollution, coupled with the roughly 50 percent loss of the microorganism during aerosol dissemination or 90 percent loss during explosive dissemination.

The revolution in genetic engineering provides a path for overcoming delivery issues and escalating a biological attack into a pandemic. First, tools for analyzing and altering a microorganisms DNA or RNA are available and affordable worldwide. The introduction of clustered regularly interspersed short palindromic repeats (CRISPR) a technique that acts like scissors or a pencil to alter DNA sequences and gene functions in 2013 made biodefense more challenging. Even as experienced researchers struggle to control clustered regularly interspersed short palindromic repeats and prevent unintended effects, malevolent actors with newfound access can attempt to manipulate existing agents to increase contagiousness; improve resistance to antibiotics, vaccines, and anti-virals; enhance survivability in the environment; and develop means of mass production. Infamously, Australian researchers in 2001 endeavored to induce infertility in mice by inserting the interleukin-4 gene into the mousepox virus. Instead, they inadvertently altered the virus to become more virulent and kill previously vaccinated mice, insinuating that the same could be done with smallpox for humans.

Moving one step further, genetic engineering raises the possibility of creating completely new biological weapons from scratch via methods similar to the test-tube synthesis of poliovirus in 2002. It is, thankfully, hard to use this process to create agents that can kill humans. However, genetic engineering can be used to create non-lethal weapons that, when coupled with longer-range delivery devices, could kill crops and animals, and destroy materials fuel, plastic, rubber, stealth paints, and constructional supplies that are critical to the economy.

Skeptics might question why a rational adversary would risk creating and employing bioweapons that are unpredictable and relatively hard to deliver to a target. First, some potential terrorists are irrational in the sense that death does not deter their service to a higher purpose; or, they may simply show a willingness to carry out orders from a state sponsor or a lack of concern for public opinion. Second, future st
ate aggressors might genetically engineer a vaccine to immunize their populations prior to unleashing a bioweapon so that the attack would only be indiscriminate within targeted nations. Third, the unprecedented harm done by COVID-19 demands a transformation of 9/11-era priorities to recognize that preparing for domestic threats like pandemics will be far greater concerns for most Americans than threats from foreign adversaries. Bioweapons combine the worst of these national and international threats.

Ultimately, for a bioweapon attack to turn into a pandemic like the SARS-CoV-2 virus, three initial conditions must be met: first, the microorganism or toxin must not have an effective remedy available; second, it must be easily transmittable; and third, it must be fatal for some victims. Whereas a number of natural-born microbes satisfied these conditions in the past, it is possible for a genetically engineered bioweapon to have the same strategic impact in the future.

Prepare for the Worst

John Barrys The Great Influenza: The Story of the Deadliest Pandemic in History provides insight into what the world might look like in the approaching age of biological attacks. It portrays how researchers failed to counter the 1918 flu strain while it spread to one-third of the global population. With a mortality rate of approximately 20 percent, the Spanish flus viral mutations proved especially fatal for military members with strong immune systems. Young people with previous exposure to milder flu strains likely suffered from immunological memory, which prompted a dysregulated immune response to the 1918 strain. At the time of the books publication in 2004, President George W. Bush took notice.

In a November 2005 speech at the National Institutes of Health, with Fauci notably in attendance, Bush warned, If we wait for a pandemic to appear, it will be too late to prepare. And one day many lives could be needlessly lost because we failed to act today. Similarly, the government should prepare now to respond to a future bioweapon attack whether from terrorism or interstate warfare. This preparation ought to proceed along three categories of action: deterrence, disruption, and defense.

Deterrence

In the realm of biological warfare, the most effective way to save lives is to persuade an adversary that an attack will not succeed. Specifically, deterrence by denial makes the act of aggression unprofitable by rendering the target harder to take, harder to keep, or both. To this end, the United States can harden its biowarfare response by increasing interagency cooperation, wargaming the resulting plans, and compiling the materials required for their execution.

The Department of Defense the largest agency in the U.S. government is the logical choice to organize a whole-of-government approach to countering bioweapons. Last November, the Pentagon released the Joint Countering Weapons of Mass Destruction doctrine, which outlined how the military will synchronize its response with governmental stakeholders like the Director of National Intelligence, the United States Agency for International Development, the Department of Energy, and the Department of Health and Human Services. Partnerships, however, should expand beyond governmental agencies via a military joint task force with leadership from the medical community and information technology professionals. The Department of Homeland Security and Centers for Disease Control should coordinate with medical schools to incorporate more curriculum and periodic exercises on pandemic control and emergency response. Likewise, the Pentagon should develop best practices for establishing communications, sustaining services, and combatting disinformation during a pandemic.

While increased interagency cooperation will encourage more robust pandemic plans, wargaming is key to testing how such plans fare in a biowarfare crisis. Last September, the Naval War College in Newport, Rhode Island, ran a two-day wargame called Urban Outbreak 2019, in which 50 experts combatted a notional pandemic. Even though this scenario had a vaccine available from the start, the findings offer prescient insight into actions surrounding COVID-19 particularly that experienced leaders may display significant resistance when encountering first-time situations or prevent troops from interfacing with infected populations. Military and agency leaders should use wargames with worst-case, extraordinary bioweapons to recognize and overcome inherent biases while simultaneously brainstorming how to lower infection rates, implement quarantines, and communicate best practices to the public.

Wargaming should also help planners identify which materials require stockpiling ahead of the next pandemic. COVID-19, for example, exposed shortages of durable protective masks, hand sanitizer, antiseptic wipes, and surface cleaners. The 300,000 businesses that make up the defense industrial base should prepare for the research, production, and delivery of personal protective equipment whenever shortages arise. They should also expect to be tapped for antibiotic, vaccine, or anti-viral production, depending on the nature of the bioweapon.

Disruption

A pandemic is a lot like a forest fire, Bush said in his 2005 speech. If caught early it might be extinguished with limited damage. If deterrence fails, American policy should focus on the early detection and disruption of bioweapons. To achieve this goal, the United States can advocate for increased verification measures and high-performing information operations.

Although the Biological Weapons Convention went into force in 1975 and has 182 state parties, the treaty lacks verification procedures and merely prohibits the production, stockpiling, and transfer of biological agents for warfare purposes. Since the treaty permits defensive research, a major challenge is the dual-use nature of production chains, wherein the technology for allowable projects also supports harmful weapons. Given the complex and sensitive nature of vital biological research, the United States has chosen not to support the establishment of a verification agency for routine facility inspections. This choice stands in contrast to the American approach toward the Organization for the Prohibition of Chemical Weapons and the International Atomic Energy Agency, both of which have robust verification mechanisms. Without this accountability, however, the Soviet Union established the Biopreparat after signing the Biological Weapons Convention treaty, employing over 50,000 people to produce tons of anthrax bacilli, smallpox virus, and multidrug-resistant plague bacteria.

To assist with the early warning of bioweapon threats, the United States should improve its understanding of international biological facilities. For instance, International Gene Synthesis Consortium members use automated software and a common protocol to screen their customers, as well as synthetic gene orders with dangerous sequences from the Regulated Pathogen Database. Particular attention should be paid to biosafety level-4 and biosafety level-3 labs around the world, where human error has led to the unintentional escape of pathogens. The U.K. foot and mouth outbreak of 2007 was traced to a faulty waste disposal system at Pirbright Laboratory in Surrey. Additionally, SARS laboratory accidents occurred in China in 2004. Increasing the priority given to intelligence gathering and analysis related to bioweapons would be an important step in the right direction.

Defense

If the United States is unable to deter or disrupt a bioweapons attack, it should be prepared to execute a strong defense against it. First and foremost, the military ought to maintain the health of its servicemembers through a COVID-19-inspired operational plan for screening and quarantine. This plan would facilitate prompt and sustained emergency responses and combat operations, including key missions like strategic nuclear deterrent patrols. Domestically, the military will need to assist in civil support, law enforcement, border patr
ol, and the defense of critical infrastructure. Internationally, the Defense Department will serve as a logistics powerhouse.

At home, the armed forces have the manpower and experience to aid in a variety of national security sectors. In addition to the deployment of U.S. Navy hospital ships to New York City and Los Angeles during COVID-19, the National Guard has conducted drive-through testing, delivered water to vulnerable populations, and carried out state governors law enforcement orders for curfews and quarantines. For critical national infrastructure, the military will serve as first responders to newfound issues with electrical generation, water purification, sanitation, and information technology.

Abroad, the military could benefit from military-to-military planning and exercises with what former Supreme Allied Commander Europe Adm. (ret.) James Stavridis calls the equivalent of a North Atlantic Treaty Organization against pandemics. In the absence of this organization, the Air Force can coordinate logistics efforts to move overseas medical supplies to the United States and bring Americans home.

The United States should draw lessons learned from past international pandemic responses. The cholera outbreak among half a million Haitians following a 2010 earthquake demonstrated that the American military could work with international military counterparts to regenerate critical infrastructure in other countries. The Ebola outbreak in West Africa in 2014 extended that cooperation to nongovernmental organizations like the Red Cross, Doctors Without Borders, and Project Hope.

Successful military cooperation abroad will fulfill basic international needs and build trust for peaceful scientific cooperation, shifting the focus to future questions like whether the bioweapon is mutating, how environmental factors affect its spread, if infected people develop short- or long-term immunity, and which mitigation efforts are effective. Successful in-situ defense will fill interdisciplinary gaps in deterrence and disruption while a layered 3D approach will determine how well the world fares during the most dangerous pandemic yet.

Conclusion

The COVID-19 pandemic foreshadows how a future bioweapons attack would unfold without proper preparation. Planning for a bioweapons attack is incredibly difficult bioweapons can be delivered by states or terrorist groups, originate from existing agents or from scratch, and can be delivered in a number of different ways. While establishing a permanent military joint task force with appropriate funding is an achievable first step, combined efforts in deterrence, disruption, and defense are key in anticipating these variables of an attack and surviving it once unleashed.

Lt. Andrea Howard is a nuclear submarine officer aboard the USS Ohio. Following her graduation from the U.S. Naval Academy in 2015, she was a Marshall Scholar at the University of Oxford and Kings College London, where she focused on the intersection of technology, security, and diplomacy in weapons of mass destruction policy. Lt. Howard won the U.S. Naval Institutes 2019 Emerging and Disruptive Technologies Essay Contest and is a member of the Seattle Chapter of the Truman National Security Project.

Image: North Carolina Air National Guard (Photo by Tech. Sgt. Julianne Showalter)

More:
The Pandemic and America's Response to Future Bioweapons - War on the Rocks

The pieces of the puzzle of covid-19s origin are coming to light – The Economist

Apr 29th 2020

Editors note: The Economist is making some of its most important coverage of the covid-19 pandemic freely available to readers of The Economist Today, our daily newsletter. To receive it, register here. For our coronavirus tracker and more coverage, see our hub

AURIC GOLDFINGER, villain of the novel which bears his name, quotes a vivid Chicago aphorism to James Bond: Once is happenstance, twice is coincidence, the third time its enemy action.

Until 2002 medical science knew of a handful of coronaviruses that infected human beings, none of which caused serious illness. Then, in 2002, a virus now called SARS-CoV surfaced in the Chinese province of Guangdong. The subsequent outbreak of severe acute respiratory syndrome (SARS) killed 774 people around the world before it was brought under control. In 2012 another new illness, Middle Eastern respiratory syndrome (MERS), heralded the arrival of MERS-CoV, which while not spreading as far and as wide as SARS (bar an excursion to South Korea) has not yet been eliminated. It has killed 858 people to date, the most recent of them on February 4th.

The third time, it was SARS-CoV-2, now responsible for 225,000 covid-19 deaths. Both SARS-CoV and MERS-CoV are closely related to coronaviruses found in wild bats. In the case of SARS-CoV, the accepted story is that the virus spread from bats in a cave in Yunnan province into civets, which were sold at markets in Guangdong. In the case of MERS-CoV, the virus spread from bats into camels. It now passes regularly from camels to humans, which makes it hard to eliminate, but only spreads between people in conditions of close proximity, which makes it manageable.

Third time unluckyAn origin among bats seems overwhelmingly likely for SARS-CoV-2, too. The route it took from bat to human, though, has yet to be identified. If, like MERS-CoV, the virus is still circulating in an animal reservoir, it could break out again in the future. If not, some other virus will surely try something similar. Peter Ben Embarek, an expert on zoonoses (diseases passed from animals to people) at the World Health Organisation, says that such spillovers are becoming more common as humans and their farmed animals push into new areas where they have closer contact with wildlife. Understanding the detail of how such spillovers occur should provide insights into stopping them.

In some minds, though, the possibility looms of enemy action on the part of something larger than a virus. Since the advent of genetic engineering in the 1970s, conspiracy theorists have pointed to pretty much every new infectious disease, from AIDS to Ebola to MERS to Lyme disease to SARS to Zika, as being a result of human tinkering or malevolence.

The politics of the covid-19 pandemic mean that this time such theories have an even greater appeal than normal. The pandemic started in China, where the governments ingrained urge to cover problems up led it to delay measures that might have curtailed its spread. It has claimed its greatest toll in America, where the recorded number of covid-19 deaths already outstrips the number of names on the Vietnam War Memorial in Washington, DC.

These facts would have led to accusations ringing out across the Pacific come what may. What makes things worse is a suspicion in some quarters that SARS-CoV-2 might in some way be connected to Chinese virological research, and that saying so may reapportion any blame.

There is no evidence for the claim. Western experts say categorically that the sequence of the new viruss genomewhich Chinese scientists published early on, openly and accuratelyreveals none of the telltales genetic engineering would leave in its wake. But it remains a fact that in Wuhan, where the outbreak was first spotted, there is a laboratory where scientists have in the past deliberately made coronaviruses more pathogenic.

Such research is carried out in laboratories around the world. Its proponents see it as a vital way of studying the question that covid-19 has brought so cruelly into the spotlight: how does a virus become the sort of thing that starts a pandemic? That some of this research has been done at the Wuhan Institute of Virology (WIV) seems all but certainly a coincidence. Without a compelling alternative account of the diseases origin, however, there is room for doubt to remain.

The 4% differenceThe origin of the virus behind the 2003 SARS outbreakclassic SARS, as some virologists now wryly call itwas established in large part by Shi Zhengli, a researcher at WIV sometimes referred to in Chinese media as the bat lady. Over a period of years she and her team visited remote locations all across the country in search of a close relative of SARS-CoV in bats or their guano. They found one in a cave full of horseshoe bats in Yunnan.

It is in the collection of viral genomes assembled during those studies that scientists have now found the bat virus closest to SARS-CoV-2. A strain called RaTG13 gathered in the same cave in Yunnan shares 96% of its genetic sequence with the new virus. RaTG13 is not that viruss ancestor. It is something more like its cousin. Edward Holmes, a virologist at the University of Sydney, estimates that the 4% difference between the two represents at least 20 years of evolutionary divergence from some common antecedent, and probably something more like 50.

Although bats could, in theory, have passed a virus descended from that antecedent directly to humans, experts find the idea unlikely. The bat viruses look different from SARS-CoV-2 in a specific way. In SARS-CoV-2 the spike protein on the viral particles surface has a receptor-binding domain (RBD) that is adept at sticking to a particular molecule on the surface of the human cells the virus infects. The RBD in bat coronaviruses is not the same.

One recent study suggests that SARS-CoV-2 is the product of natural genomic recombination. Different coronaviruses infecting the same host are more than happy to swap bits of genome. If a bat virus similar to RaTG13 got into an animal already infected with a coronavirus which boasted an RBD better suited to infecting humans, a basically batty virus with a more human-attuned RBD might well arise. That is what SARS-CoV-2 looks like.

Early on, it was widely imagined that the intermediate host was likely to be a species sold in Wuhans Huanan Seafood and Wildlife Market, a place where all sorts of creatures, from raccoon dogs to ferret badgers, and from near and far, are crammed together in unsanitary conditions. Many early human cases of covid-19 were associated with this market. Jonathan Epstein, vice-president of science with EcoHealth Alliance, an NGO, says of 585 swabs of different surfaces around the market, about 33 were positive for SARS-CoV-2. They all came from the area known to sell wild animals. That is pretty much as strong as circumstantial evidence gets.

The first animal to come under serious suspicion was the pangolin. A coronavirus found in pangolins has an RBD essentially identical to that of SARS-CoV-2, suggesting that it might have been the virus with which the bat virus recombined on its way to becoming SARS-CoV-2. Pangolins are used in traditional medicine, and though they are endangered, they can nonetheless be found on menus. There are apparently no records of them being traded at the Huanan market. But given that such trading is illegal, and that such records would now look rather incriminating, this is hardly proof that they were not.

The fact that pangolins are known to harbour viruses from which SARS-CoV-2 could have picked up its human-compatible RBD is certainly suggestive. But a range of other animals might harbour such viruses, too; its just that scientists have not yet looked all that thoroughly. The RBD in SARS-CoV-2 is useful not only for attacking the cells of human beings and, presumably, pangolins. It provides access to similar cells in other species, too. In recent weeks SARS-CoV-2 has been shown to have found its way from humans into domestic cats, farmed mink and
a tiger. There is some evidence that it can actually pass between cats, which makes it conceivable that they were the intermediatethough there is as yet no evidence of a cat infecting a human.

The markets appeal as a site for the human infections behind the Wuhan outbreak remains strong; a market in Guangdong is blamed for the spread of SARS. Without a known intermediate, though, the evidence against it remains circumstantial. Though many early human cases were associated with the market, plenty were not. They may have been linked to people with ties to the market in ways not yet known. But one cannot be sure.

Where to begin?The viral genomes found in early patients are so similar as to suggest strongly that the virus jumped from its intermediate host to people only once. Estimates based on the rate at which genomes diverge give the earliest time for this transfer as early October 2019. If that is right there were almost certainly infections which were not serious, or which did not reach hospitals, or which were not recognised as odd, before the first official cases were seen in Wuhan at the beginning of December. Those early cases may have taken place elsewhere.

Ian Lipkin, the boss of the Centre for Infection and Immunity at Columbia University, in New York, is working with Chinese researchers to test blood samples taken late last year from patients with pneumonia all around China, to see if there is any evidence for the virus having spread to Wuhan from somewhere else. If there is, then it may have entered Huanan market not in a cage, but on two legs. The market is popular with visitors as well as locals, and is close to Hankou railway station, a hub in Chinas high-speed rail network.

Further research may make when, where and how the virus got into people clearer. There is scope for a lot more virus hunting in a wider range of possible intermediate species. If it were possible to conduct detailed interviews with those who came down with the earliest cases of covid-19, that genetic sampling could be better aimed, says Dr Embarek, and with a bit of luck one might get to the source. But the time needed to do this, he adds, might be quick, or it might be extremely long.

If it turns out to have originated elsewhere, the new viruss identification during the early stages of the Wuhan epidemic may turn out to be thanks to the citys concentration of virological know-howknow-how that is now surely being thrown into sequencing more viruses from more sources. But until a satisfactory account of a natural spillover is achieved, that same concentration of know-how, at WIV and another local research centre, the Wuhan Centre for Disease Control and Prevention, will continue to attract suspicion.

In 2017 WIV opened the first biosecurity-level 4 (BSL-4) laboratory in Chinathe sort of high-containment facility in which work is done on the most dangerous pathogens. A large part of Dr Shis post-SARS research there has been aimed at understanding the potential which viruses still circulating among bats have to spill over into the human population. In one experiment she and Ge Xingyi, also of the WIV, in collaboration with American and Italian scientists, explored the disease-like potential of a bat coronavirus, SHC014-CoV, by recombining its genome with that of a mouse-infecting coronavirus. The WIV newsletter of November 2015 reported that the resulting virus could replicate efficiently in primary human airway cells and achieve in vitro titres equivalent to epidemic strains of SARS-CoV. In early April this newsletter and all others were removed from the institutes website.

This work, results from which were also published in Nature Medicine, demonstrated that SARS-CoVs jump from bats to humans had not been a fluke; other bat coronaviruses were capable of something similar. Useful to know. But giving pathogens and potential pathogens extra powers in order to understand what they may be capable of is a controversial undertaking. These gain of function experiments, their proponents insist, have important uses such as understanding drug resistance and the tricks viruses employ to evade the immune system. They also carry obvious risks: the techniques on which they depend could be abused; their products could leak. The creation of an enhanced strain of bird flu in 2011 in an attempt to understand the peculiar virulence of the flu strain responsible for the pandemic of 1918-19 caused widespread alarm. America stopped funding gain-of-function work for several years.

Filippa Lentzos, who studies biomedicine and security at Kings College, London, says the possibility of SARS-CoV-2 having an origin connected with legitimate research is being discussed widely in the world of biosecurity. The possibilities speculated about include a leak of material from a laboratory and also the accidental infection of a human being in the course of work either in a lab or in the field.

Leaks from laboratories, including BSL-4 labs, are not unheard of. The worlds last known case of smallpox was caused by a leak from a British laboratory in 1978. An outbreak of foot and mouth disease in 2007 had a similar origin. In America there have been accidental releases and mishandlings involving Ebola, and, from a lower-containment-level laboratory, a deadly strain of bird flu. In China laboratory workers seem to have been infected with SARS and transmitted it to contacts outside on at least two occasions.

Heres one I made earlierThings doubtless leak out of labs working at lower biosafety levels, too. But how much they do so is unknown, in part because people worry about them less. And as in other parts of this story the unknown is a Petri dish in which speculation can grow. This may be part of the reason for interest in a lab at the Wuhan Centre for Disease Control and Prevention. A preprint published on ResearchGate, a website, by two Chinese scientists and subsequently removed suggested that work done there may have been cause for concern. This lab is reported to have housed animalsincluding, for one study, hundreds of bats from Hubei and Zhejiang provincesand to have specialised in pathogen collection.

Richard Pilch, who works on chemical and biological weapons non-proliferation at the Middlebury Institute of International Studies, in California, says that there is one feature of the new virus which might conceivably have arisen during passaging experiments in which pathogens are passed between hosts so as to study the evolution of their ability to spread. This is the polybasic cleavage site, which might enhance infectivity. SARS-CoV-2 has such a site on its spike protein. Its closest relatives among bat coronaviruses do not. But though such a cleavage site could have arisen through passaging there is no evidence that, in this case, it did. It could also have evolved in the normal way as the virus passed from host to host. Dr Holmes, meanwhile, has said that there is no evidence that SARS-CoV-2...originated in a laboratory in Wuhan, China. Though others have speculated about coincidences and possibilities, no one has been able, as yet, to undermine that statement.

Many scientists think that with so many biologists actively hunting for bat viruses, and gain-of-function work becoming more common, the world is at increasing risk of a laboratory-derived pandemic at some point. One of my biggest hopes out of this pandemic is that we address this issueit really worries me, says Dr Pilch. Today there are around 70 BSL-4 sites in 30 countries. More such facilities are planned.

Again, though, it is necessary to consider the unknown. Every year there are tens of thousands of fatal cases of respiratory disease around the world of which the cause is mysterious. Some of them may be the result of unrecognised zoonoses. The question of whether they really are, and how those threats may stack up, needs attention. That attention needs laboratories. It also needs a degree of open co-operation that America is now degrading with accusations and reductions in funding, and that China has taken steps to suppress at source. That suppr
ession has done nothing to help the country; indeed, by supporting speculation, it may yet harm it.

Dig deeper:

For our latest coverage of the covid-19 pandemic, register for The Economist Today, our daily newsletter, or visit our coronavirus tracker and story hub

Go here to see the original:
The pieces of the puzzle of covid-19s origin are coming to light - The Economist

Where did Covid-19 come from? What we know about its origins – The Guardian

Why are the origins of the pandemic so controversial?

How Covid-19 began has become increasingly contentious, with the US and other allies suggesting China has not been transparent about the origins of the outbreak.

Donald Trump, the US president, has given credence to the idea that intelligence exists suggesting the virus may have escaped from a lab in Wuhan, although the US intelligence community has pointedly declined to back this up. The scientific community says there is no current evidence for this claim.

This follows reports that the White House had been pressuring US intelligence community on the claim, recalling the Bush administrations pressure to stove pipe the intelligence before the war in Iraq.

A specific issue is that the official origin story doesnt add up in terms of the initial epidemiology of the outbreak, not least the incidence of early cases with no apparent connection to the Wuhan seafood market, where Beijing says the outbreak began. If these people were not infected at the market, or via contacts who were infected at the market, critics ask, how do you explain these cases?

Two laboratories in Wuhan studying bat coronaviruses have come under the spotlight. The Wuhan Institute of Virology (WIV) is a biosecurity level 4 facility the highest for biocontainment and the level 2 Wuhan Centre for Disease Control, which is located not far from the fish market, had collected bat coronavirus specimens.

Several theories have been promoted. The first, and wildest, is that scientists at WIV were engaged in experiments with bat coronavirus, involving so-called gene splicing, and the virus then escaped and infected humans. A second version is that sloppy biosecurity among lab staff and in procedures, perhaps in the collection or disposal of animal specimens, released a wild virus.

The scientific consensus rejecting the virus being engineered is almost unanimous. In a letter to Nature in March, a team in California led by microbiology professor Kristian Andersen said the genetic data irrefutably shows that [Covid-19] is not derived from any previously used virus backbone in other words spliced sections of another known virus.

Far more likely, they suggested, was that the virus emerged naturally and became stronger through natural selection. We propose two scenarios that can plausibly explain the origin of Sars-CoV-2: natural selection in an animal host before zoonotic [animal to human] transfer; and natural selection in humans following zoonotic transfer.

Peter Ben Embarek, an expert at the World Health Organization in animal to human transmission of diseases, and other specialists also explained to the Guardian that if there had been any manipulation of the virus you would expect to see evidence in both the gene sequences and also distortion in the data of the family tree of mutations a so-called reticulation effect.

In a statement to the Guardian, James Le Duc, the head of the Galveston National Laboratory in the US, the biggest active biocontainment facility on a US academic campus, also poured cold water on the suggestion.

There is convincing evidence that the new virus was not the result of intentional genetic engineering and that it almost certainly originated from nature, given its high similarity to other known bat-associated coronaviruses, he said.

The accidental release of a wild sample has been the focus of most attention, although the evidence offered is at best highly circumstantial.

The Washington Post has reported concerns in 2018 over security and management weakness from US embassy officials who visited the WIV several times, although the paper also conceded there was no conclusive proof the lab was the source of the outbreak.

Le Duc, however, paints a different picture of the WIV. I have visited and toured the new BSL4 laboratory in Wuhan, prior to it starting operations in 2017- It is of comparable quality and safety measures as any currently in operation in the US or Europe.

He also described encounters with Shi Zhengli, the Chinese virologist at the WIV who has led research into bat coronaviruses, and discovered the link between bats and the Sars virus that caused disease worldwide in 2003, describing her as fully engaged, very open and transparent about her work, and eager to collaborate.

Maureen Miller, an epidemiologist who worked with Shi as part of a US-funded viral research programme, echoed Le Ducs assessment. She said she believed the lab escape theory was an absolute conspiracy theory and referred to Shi as brilliant.

While the experts who spoke to the Guardian made clear that understanding of the origins of the virus remained provisional, they added that the current state of knowledge of the initial spread also created problems for the lab escape theory.

When Peter Forster, a geneticist at Cambridge, compared sequences of the virus genome collected early in the Chines outbreak and later globally he identified three dominant strains.

Early in the outbreak, two strains appear to have been in circulation at roughly at the same time strain A and strain B with a C variant later developing from strain B.

But in a surprise finding, the version with the closest genetic similarity to bat coronavirus was not the one most prevalent early on in the central Chinese city of Wuhan but instead associated with a scattering of early cases in the southern Guangdong province.

Between 24 December 2019 and 17 January 2020, Forster explains, just three out of 23 cases in Wuhan were type A, while the rest were type B. In patients in Guangdong province, however, five out of nine were found to have type A of the virus.

The very small numbers notwithstanding, said Forster, the early genome frequencies until 17 January do not favour Wuhan as an origin over other parts of China, for example five of nine Guangdong/Shenzhen patients who had A types.

In other words, it still remains far from certain that Wuhan was even necessarily where the virus first emerged.

The pandemic has exacerbated existing geopolitical struggles, prompting a disinformation war that has drawn in the US, China, Russia and others.

Journalists and scientists have been targeted by people with an apparent interest in pushing circumstantial evidence related to the viruss origins, perhaps as part of this campaign and to distract from the fact that few governments have had a fault-free response.

The current state of knowledge about coronavirus and its origin suggest the most likely explanation remains the most prosaic. Like other coronaviruses before, it simply spread to humans via a natural event, the starting point for many in the scientific community including the World Health Organization.

Further testing in China in the months ahead may eventually establish the source of the outbreak. But for now it is too early.

Read more from the original source:
Where did Covid-19 come from? What we know about its origins - The Guardian

Perspective on Pharma: Moving from academia to industry – EPM Magazine

In this Perspective on Pharma feature, Jung Doh, market development scientist at Beckman Coulter Life Sciences, explains how they entered the pharmaceutical industry after an unexpected opportunity arose.

As an early career scientist with a good number of years of graduate and post-doctoral training (two post-docs, actually), I made an unexpected leap: from academiawhere I thought I would spend my entire professional lifeto industry. And though it wasnt a move Id initially planned, Im the first to say that Im incredibly happy to have ended up here, since its afforded me research and personal growth opportunities I didnt even know I wanted.

After I received my doctorate in biology, I completed a post-doc in HIV research and a second, NASA-funded post-doc in the effects of microgravity on genomes. My dreamand a very concrete goal for many yearswas to become a professor at a research university, running my own lab in an area I was passionate about.

But then life intervened: my wife was offered a teaching position in Indianapolis that she couldnt pass up, so we relocated. After a few months of fruitless application to teaching and research positions at local universities, I started looking elsewhere. There are a lot of pharma and biotech companies in Indianapolis, so I started exploring some of them. In the interview process, (and much to my surprise), I discovered that they shared many of the same passions and goals I did: to benefit human health and life in fundamental and lasting ways.

The company where I ended up and still work, Beckman Coulter Life Sciences, was particularly interesting to me, since one of their key focuses was on next generation sequencing (NGS). Toward the end of my Ph.D. and in my post-doc training, NGS was becoming more routine, and I was fortunate to be able to learn and apply the techniques in my own research.

So I joined Beckman Coulter Life Sciences, which offers a range of scientific research instruments used to study complex biological problems and to advance scientific breakthroughs, first as a marketing application scientist, and then expanding into a dual role as application scientist and proof of principle scientist. In the latter, I worked with customers to develop modified protocols and tools to help research be done more efficiently. I then became product manager for our genomics product line, and as of this year, I have yet another new role, as market development scientist. In this role, I engage with the scientific community to learn from them, as well as support them to perform research better, faster, and with superior results and outcomes. I also bring the learnings and techniques gained from these collaborations to create collateral to offer other labs, or help our internal team develop product offerings for a specific need.

After making the leap into industry, I never looked back. There are, of course, benefits to both sectors. In academia, theres a certain degree of freedom and job securityonce youre tenured, that is. But it takes a lot to get tenured these daysthe funding and grants and a constant stream of publicationsparticularly in biology and related disciplines.

Though industry may seem more constrained at first glance, in many ways, theres as much or more opportunity, since there are a plethora of techniques to learn and apply in novel ways. And since technology evolves so rapidly, especially in genetic engineering and diagnostics, it seems like there are always new methods to master.

Related to this aspect, and alluded to earlier, is the strong sense that my and my colleagues work is genuinely translating into helping people across the globe. I got an inkling of that in the interview process, but its also been a palpable part of my work here. With the current pandemic, for instance, the company came together, and, within a matter of weeks, we were able to offer labs RNA extraction solutions for the virus, which are so critical right now. I felt honoured to be part of a company doing such great work, with flexibility and speed. It definitely speaks to the versatility of the industry.

Beyond the scientific, Ive learned about areas seemingly outside of science, but that are actually integral parts of the business. When I was product manager, for instance, I learned how to manage people, run meetings, build financial models, approach marketing and sales, and many other facets of the business. I had no formal business training going in, but you learn by doing, from your manager and peers. I ended up really loving all these other parts of the business of sciencetheyre challenging, but incredibly rewarding, because they push you beyond your comfort zone into uncharted areas. For that, industry has opened up areas that I didnt even know would be important, let alone fun and rewarding.

Finally, Ive been surprised and heartened by the strong sense of family that exists within a company. Part of this is felt through the opportunities for development, which is evident in all the stages I went through and all the roles Ive had. Theres a sense that staff are supported to grow as scientists and as people, which has made my accidental leap into industry all the more fulfilling.

For young scientists, theres a lot to think about when making decisions about what to study and what track to follow. I would encourage people to not get too hung up on tracks, but to stay open to the possibilitiesin other words, dont get too stuck on academia as the only option just because its where youve done your training. What really matters is having a passion for what you do, and following your interests. Genetic engineering is an area thats exploded in recent years, and will likely grow in the coming years. Ive been lucky that my own work has translated so tangibly into helping people, and at a large scalebut the same is true for many other areas in medical science. So carry onyou may end up in a totally different place from where you started, and thats not a bad thing at all.

More:
Perspective on Pharma: Moving from academia to industry - EPM Magazine

CRISPR Market to Witness Exponential Growth by 2020-2027 | Leading Players Thermo Fisher Scientific, Editas Medicine, Caribou Biosciences, CRISPR…

Fort Collins, Colorado The report on the CRISPR Market provides an in-depth assessment of the CRISPR market including technological advancements, market drivers, challenges, current and emerging trends, opportunities, threats, risks, strategic developments, product advancements, and other key features. The report covers market size estimation, share, growth rate, global position, and regional analysis of the market. The report also covers forecast estimations for investments in the CRISPR industry from 2020 to 2027.

The report is furnished with the latest market dynamics and economic scenario in regards to the COVID-19 pandemic. The pandemic has brought about drastic changes in the economy of the world and has affected several key segments and growth opportunities. The report provides an in-depth impact analysis of the pandemic on the market to better understand the latest changes in the market and gain a futuristic outlook on a post-COVID-19 scenario.

Global CRISPR Market Size Study by Application(Genome Editing, Genetic Engineering, Gene Library, CRISPR Plasmid, Human Stem cells, Genetically Modified Organism, Cell Line Engineering), by End-User (Biotechnology Companies, Pharmaceutical Companies, Academic Institutes, Research & Development Institutes) and Regional Forecast 2017-2025.

Get a sample of the report @ https://reportsglobe.com/download-sample/?rid=5977

The report provides an in-depth analysis of the key developments and innovations of the market, such as research and development advancements, product launches, mergers & acquisitions, joint ventures, partnerships, government deals, and collaborations. The report provides a comprehensive overview of the regional growth of each market player.

Additionally, the report provides details about the revenue estimation, financial standings, capacity, import/export, supply and demand ratio, production and consumption trends, CAGR, market share, market growth dynamics, and market segmentation analysis.

The report covers extensive analysis of the key market players in the market, along with their business overview, expansion plans, and strategies. The key players studied in the report include:

Furthermore, the report utilizes advanced analytical tools such as SWOT analysis and Porters Five Forces Analysis to analyze key industry players and their market scope. The report also provides feasibility analysis and investment return analysis. It also provides strategic recommendations to formulate investment strategies and provides insights for new entrants.

Request a discount on the report @ https://reportsglobe.com/ask-for-discount/?rid=5977

The report is designed with an aim to assist the reader in taking beneficial data and making fruitful decisions to accelerate their businesses. The report provides an examination of the economic scenario, along with benefits, limitations, supply, production, demands, and development rate of the market.

By Applications:

By End User:

Request customization of the report @https://reportsglobe.com/need-customization/?rid=5977

Regional Analysis of the Market:

For a better understanding of the global CRISPR market dynamics, a regional analysis of the market across key geographical areas is offered in the report. The market is spread acrossNorth America, Europe, Latin America, Asia-Pacific, and Middle East & Africa.Each region is analyzed on the basis of the market scenario in the major countries of the regions to provide a deeper understanding of the market.

Benefits of the Global CRISPR Report:

To learn more about the report, visit @ https://reportsglobe.com/product/global-crispr-market/

Thank you for reading our report. To learn more about report details or for customization information, please contact us. Our team will ensure that the report is customized according to your requirements.

How Reports Globe is different than other Market Research Providers

The inception of Reports Globe has been backed by providing clients with a holistic view of market conditions and future possibilities/opportunities to reap maximum profits out of their businesses and assist in decision making. Our team of in-house analysts and consultants works tirelessly to understand your needs and suggest the best possible solutions to fulfill your research requirements.

Our team at Reports Globe follows a rigorous process of data validation, which allows us to publish reports from publishers with minimum or no deviations. Reports Globe collects, segregates, and publishes more than 500 reports annually that cater to products and services across numerous domains.

Contact us:

Mr. Mark Willams

Account Manager

US: +1-970-672-0390

Email:[emailprotected]

Web:reportsglobe.com

See the original post:
CRISPR Market to Witness Exponential Growth by 2020-2027 | Leading Players Thermo Fisher Scientific, Editas Medicine, Caribou Biosciences, CRISPR...

The Unfinished Project of Enlightenment – Boston Review

Frontispiece to the 1772 edition of the Encyclopdie by Diderot and d'Alembert. At the center, crowned Reason attempts to remove the veil from Truth. Image: Wikimedia Commons

In a sweeping new history of Western philosophy,Jrgen Habermas narrates the progress of humanity through the unfolding of public reason. Missing from that story are the systems of violence and dispossession whose legacies are all too visible today.

Auch eine Geschichte der Philosophie (This Too a History of Philosophy)Vol. 1, Die okzidentale Konstellation von Glauben und Wissen (The Occidental Constellation of Faith and Knowledge)Vol. 2, Vernnftige Freiheit. Spuren des Diskurses ber Glauben und Wissen (Rational Liberty: Traces of the Discourse on Faith and Knowledge)Jrgen HabermasSuhrkamp Verlag, 98 (cloth)

No one in the world feels the weakness of general characterizing more than I. So lamented Johann Gottfried von Herder, towering figure of the German Enlightenment, in his 1774 treatise This Too a Philosophy of History for the Formation of Humanity. One draws together peoples and periods of time that follow one another in an eternal succession like waves of the sea, Herder wrote. Whom has one painted? Whom has the depicting word captured? For Herder, the Enlightenment dream of grasping human history as a seamless whole came up against the irreducible particularity of individuals and cultures.

At a time of crisis, Habermas suggests that humanity already possesses the resources for levelheaded debate oriented toward the common good.

The German philosopher and social theorist Jrgen Habermas, among the most influential thinkers of our time, grapples with much the same problem in his new work, the title of which reverses the order of Herders terms: This Too a History of Philosophy. Published in German last September, Habermass History spans over 3,000 years and 1,700 pages. It marks the apogee of a singular career. Like his eighteenth-century precursor, Habermas seeks a thoroughgoing reconceptualization of the sweep of human history. Philosophical problems, he writes, are distinctive from merely scientific ones in their synthetic force. For Habermas, the fragmentation of modern life has hardly exhausted philosophys capacity for bold questions and architectonic structure.

To be sure, the work pays homage to the legacy of postmodern critique. Wary of Herders pitfalls of general characterizing, Habermas eschews airy speculation for dense textual reconstruction. But this history of philosophy, no less than Enlightenment philosophies of history, is driven by a teleological intent, a principle that threads through historys seeming randomness and contingency. For Herder, that principle was humanitys formation (Bildung), a foundational concept of the German Enlightenment linking the moral development of the individual with the progress of civilization. For Habermas, it is instead a collective learning process (Lernprozess). History, in Habermass telling, is the story of humanitys learning, a record of problems solved and challenges overcome. New knowledge about the objective world alongside social crises, he explains, create cognitive dissonances. These dissonances propel societies to adopt novel modes of understanding and interaction.

The vehicle of Habermass learning process is language: the source of human rationality, the storehouse of humanitys accumulated knowledge, and the medium by which that knowledge can be challenged and improved. Here too Habermas plays variations on an Enlightenment theme. But there is a catch. Although immersed in the give and take of rational argument, Habermass protagonists develop metaphysical systems that obscure their own intersubjective meaning-making. For Habermas, only with the rise of modern, postmetaphysical thinking does philosophy become conscious of the learning process itself.

Tracing a continuous learning process across three millennia of Western philosophy, This Too a History of Philosophy is a masterpiece of erudition and synthesis. Habermass command of the philosophical canon astounds, and even experts will find fresh insight in his searching portraits. At the same time, his narrative of humanitys rational development invites us to pose Herders challenge anew: Whom has Habermass History captured? Most urgent is the questionraised, but not resolvedof how the learning process traversed by the West interacts with wider histories of the modern world.

Born in 1929 into Western Germanys Protestant middle class, Habermas is contemporary Europes most prominent philosopher and public intellectual. Over a prodigious career stretching nearly seven decades, he has set out a system linking epistemology, linguistics, sociology, politics, religion, and law. His philosophical texts have appeared in over forty languages. But more than that, Habermas has distinguished himself as a staunch advocate of the intellectuals public role. His exchanges with interlocutors from John Rawls to Michel Foucault have generated debate across the humanities, and his political interventions have shaped controversies on themes from historical memory to European unification to genetic engineering.

Habermass ninetieth birthday last year initiated spirited discussions of his lifes work. His lecture marking the occasion at the University of Frankfurt drew a crowd of over 3,000 listeners, while the appearance of the eight-hundred-page Cambridge Habermas Lexicon set the stage for the next phase of his reception in English. More controversially, a polemic by the political philosopher Raymond Geuss challenged the very foundations of Habermass thought and sparked a contentious exchange among scholars of critical theory. Habermas turns ninety-one today, remaining no less active and continuing to inspire and provoke.

Democracy, for Habermas, is a system where uncoerced communication triumphs over naked power, where rational argument among equal citizens forms the basis of political legitimacy.

An overarching project connects Habermass philosophical writing with his public advocacy and helps to account for his global reach: the elaboration of what he terms a theory of communicative rationality. When we address ourselves to another human being through language, Habermas argues, we assume the possibility of mutual intelligibility and rational persuasion. In an ideal speech situation, where no coercion is present save the unforced force of the better argument, dialogue would foster consensus based on rational agreement. Habermas recognizes that most communication is far from this ideal. Yet he insists that the ideal remains the prerequisite even for ordinary speech, and contains the seedbed of radical democracy. Democracy, for Habermas, is a system where uncoerced communication triumphs over naked power, where rational argument among equal citizens forms the basis of political legitimacy.

Habermass project emerged from the traumas of postwar Germany. Fifteen-years-old at the time of the Nazi collapse, Habermas had narrowly escaped military conscription and listened, horrified, to radio broadcasts of the Nuremberg trials. Determined to uncover where German history had gone so wrong, and whether German culture possessed resources for the countrys reconstruction, the Gymnasium student abandoned a planned career in medicine to pursue philosophy. In what has become a set piece of his biography, it was the 1953 republication of a Nazi-era tract by the philosopher Martin Heidegger, extolling the inner truth and greatness of National Socialism, that led the young Habermas to reject the reigning existentialism and cultural despair. He would instead find his academic home at the University of Frankfurt, among the returned German-Jewish exiles Max Horkheimer and Theodor Adorno. Their reconstituted Institute for Social Research served as a haven for critical debate amidst postwar West Germanys hidebound academic culture.

Yet even as he quickly gained recognition as the leader of the Frankfurt Schools second generation, Habermas diverged
from his predecessors. Whereas Horkheimer and Adornos Dialectic of Enlightenment (1947) tracked the decay of Western rationalism into a self-destructive instrumental reason, Habermas sought out a mode of rationality that escaped a narrow means-ends logic. This he would locate in intersubjective communication. Habermass habilitation thesis and the book that made his name, The Structural Transformation of the Public Sphere (1962), foreshadowed the centrality of communication for his lifes work. Embedding philosophical argument in historical sociology, Habermas traced the rise of a bourgeois public sphere in the coffee houses and print culture of eighteenth-century Europe. The new domain of reasoned deliberation, between the official institutions of politics and the private sphere of the family, challenged ruling authorities and fomented the spread of republican ideas. Although Structural Transformation concluded by charting the decline of the public sphere in modern mass mediaa pervasive concern in todays talk of disinformation and fake newsthe work announced its authors lifelong identification with the unfinished project of Enlightenment.

If Structural Transformation made Habermas a rising star, it was his 1981 magnum opus, The Theory of Communicative Action, that established him as a premier philosopher of the twentieth century. Theory bore the fruits of two decades of intellectual exploration, including a stint as director of the Max Planck Institute in Starnberg, Bavaria, and an ambitious program of reading across classical sociology, systems theory, ordinary language philosophy, and American pragmatism. The book marshaled all of these influences to uncover the rational foundations of communication as a path toward reenergizing democracy. The modern system of economy and bureaucracy, Habermas concluded, must be subjected to rigorous oversight by the lifeworld, the spaces of society and culture where free communication can flourish. While accepting the structures of the capitalist welfare state, Habermas warned against the colonization of the lifeworld by private interests. He would return to this theme over subsequent political writings.

When we address ourselves to another human being through language, Habermas argues, we assume the possibility of mutual intelligibility and rational persuasion. He recognizes that most communication is far from this ideal.

This Too a History of Philosophy marks the culmination of a third stage of Habermass career, one in which questions of faith and religion have assumed increasing prominence. Habermass earlier work hinged on a theory of secularization. Whatever ones private convictions, the public sphere depended on the exchange of validity claims accessible to all citizens; appeals to faith had to be checked at the door. Yet in an address one month after the attacks of September 11, 2001, Habermas characterized contemporary Western democracies as postsecular societies. The public sphere, he now argued, should accommodate religious diversity and permit the participation of religious citizens. Habermas went further in a 2005 essay that followed a public discussion with Cardinal Joseph Ratzinger (later Pope Benedict XVI). Not only should religious and secular citizens have equal access to the public sphere, but the latter can be reasonably expected not to exclude the possibility that [religious] contributions may have cognitive substance.

For some of Habermass secular-minded interlocutors, these apparent concessions to religion betrayed the rational promise of critical social theory. Yet as with so much in Habermas, what seems an about-face reflects a deepening of earlier concerns. My own research on Protestant intellectual networks in early postwar Germany uncovered evidence of Habermass participation in Christian-Marxist working groups during the early 1960s. And since the 1980s, Habermas has engaged in philosophical exchanges with prominent Christian theologians, most notably his Catholic contemporary Johann Baptist Metz. Habermass recent writings build upon his longstanding view that religious citizens can contribute moral insight to the public sphereand that they did so in a democratizing Germany. As Europe absorbs new waves of Muslim immigrants, Habermas has sought to combat xenophobic discourses of cultural difference, while fostering democratic deliberation across religious divides.

But more provocative convictions drive Habermass writings on religion as well. Notwithstanding his advocacy for a religiously plural public sphere, Habermas has remained emphatic about the foundational role of Western Christianity. Already in The Theory of Communicative Action, he drew on the classical sociologist Max Weber to trace the rise of modern purposive rationality out of the Protestant idea of vocation. More recently, Habermas has distanced himself from claims of Weberian disenchantment to suggest that the process of secularization remains incomplete. Universalistic egalitarianism, he stated in a 2002 interview, is the direct legacy of the Judaic ethic of justice and the Christian ethic of love . . . Up to this very day there is no alternative to it. Drawing a dubious contrast between the two monotheistic religions, Habermas articulated what would become the core of his intellectual program. The Wests Judeo-Christian heritage was not a passing phase in the emergence of modern thought and politics, but contributedand perhaps still contributesits essential core.

This Too a History of Philosophy is the realization of Habermass claim on a grand scale. At its most basic, the work provides a historical survey linking Habermass longstanding theory of communication with his more recent argument for the preeminence of Judeo-Christianity. The central thesis is expansive but straightforward. Communicative rationality as well as constitutional democracy emerged out of a three-thousand-year dialogue between the two poles of Western thought: faith and knowledge. Through a protracted history of intellectual debate and social transformation, the moral universalism at the core of Christianityhaving evolved out of its Jewish precursorwas subsumed into modern, postmetaphysical thinking. Habermass account of secularization departs from what the philosopher Charles Taylor has termed the subtraction story, by which irrational beliefs are stripped away with the forward march of science. Instead, Habermas reconstructs the interactions of Christian faith and worldly knowledge as a process not of conflict, but of mutual learning and translation.

Habermass learning process is rooted in the very nature of Homo sapiens as a linguistic being. Drawing on the research of the developmental psychologist Michael Tomasello, he begins with a sharp distinction between human and animal cognition. Other primates, Habermas explains, communicate to indicate objects in their own environments. But the unique social complexity of human life, manifested in the monogamous family and paleolithic hunt, catalyzed a distinctive ability to communicate intersubjectively about a shared objective world. This unique form of language allowed human beings to formulate collective solutions to common problems. Humanitys social and cultural learning could thereby outpace its biological evolution.

The Wests Judeo-Christian heritage was not a passing phase in the emergence of modern thought and politics, Habermas argues, but contributedand perhaps still contributesits essential core.

Habermas proceeds to narrate the early development of human societies along a hierarchy of communicative forms. Ritual served as the primordial medium of symbolic communication, bridging the individual and the collective. Habermas locates a shift to myth in the Near Eastern high cultures of the third millennium B.C.E., characterized by written language, scientific advancement, and political hierarchy. But the crucial transformation came in the Axial Age of Moses, Buddha, Confucius, and Platoa term Habermas borrows from the philosopher Karl Jaspers. Whereas myth collapsed god and man into one another, the Axial worldviews acco
mplished the seminal distinction between sacred and profane, eternal and temporal. In Judaisms omniscient God, Buddhisms doctrine of reincarnation, and Platos Forms, Habermas locates the foundations for the transcendental perspective of both objective science and universal morality.

Jaspers developed the concept of the Axial Age, Habermas notes, to overcome the Eurocentric narrowing of view to the Western path of cultural development. But Habermass own study takes a sharp turn toward the West. It is the particular history of Western Christianity, he argues, that leads from the nascent universalism of the Axial Age to modern postmetaphysical reason and constitutional democracy. Eastern religions became amalgamated to state power or declined in competition with new sciences. Judaism remained too bound to its sacral language and text to interact productively with its surroundings. But the unique circumstances of early Christianitys confrontation with Greek philosophy and Roman state power catalyzed a process of mutual learning. The cross-pollination of faith and knowledge found an early apex in Augustines fourth-century synthesis of Christianity and Platonism. And at the same time that Augustine introduced philosophy to the Church, Western Christianitys Roman-inspired legal system brought the Church into the realm of power politics.

Traversing the church-state conflicts of medieval Europe, Habermas arrives at thirteenth-century Italy as a new turning point: a site at which the earliest forms of proto-capitalism inaugurated the functional differentiation of modern society. Thomas Aquinas, the central thinker of the period, departed from Augustines Christian-Platonist synthesis to establish theology and philosophy as separate disciplines. Reason and faith now offered firmly independent paths toward salvation. Though Aquinas remained a monarchist, his formulation of natural law, implanted by God in human reason, opened the door to nascent democratic theories. With unprecedented criticisms of the pope, Aquinass late medieval successors theorized law as a limit on both church and state power. They prefigured an age when law would become an object of contestation among citizens.

Yet ironically, perhaps reflective of Webers ongoing influence, it is the political reactionary Martin Luther who is accorded pride of place in Habermass narrative of secularization. Luthers attack on ecclesiastical authority, Habermas argues, not only exacerbated the cleft of church and state, but located faith in the intersubjective exchange between the human being and God. Protestant hermeneutics, in which every believer became an interpreter of Scripture, foreshadowed a communicative rationality in which authority is accorded to the most convincing argument.

Habermas reconstructs the interactions of Christian faith and worldly knowledge as a process not of conflict, but of mutual learning and translation.

At the same time, Luthers attempt to secure faith from the incursions of worldly authority set up its own undoing. The Reformation, in addition to the scientific and political revolutions of the seventeenth century, tore apart the Augustinian and Thomist syntheses of ontology (what is there?) with practical philosophy (what should I do?). The secularization of state power, epitomized in the English constitutional revolution, eroded the Christian foundations of political order; the determinism of Newtonian laws threatened to undermine human free will, the kernel of Christian morality. The question of legitimacy emerged as the Achilles heel of modern thought.

David Hume and Immanuel Kant are the eighteenth-century thinkers who, for Habermas, articulated the paradigm-shifting responses to this problem. Seventeenth-century philosophers could reconcile faith and knowledge only at the expense of inconsistent foundations: consider Thomas Hobbess argument for religiously based monarchy despite his avowed atheism and John Lockes return to divinely ordained natural law. Only in Hume and Kant was the breakthrough to postmetaphysical thinking achieved. Hume disaggregated human subjectivity into a succession of sense-impressions, dissolving Christian metaphysics. But Kant emerges as the hero of Habermass narrative, the figure who reconstructed the rational core of Christianity in the wake of Humes withering critique. Kants categorical imperative, which called on individuals to posit their actions as the basis for a universal law, established a universal morality on purely rational grounds.

Habermas presents the history of post-Kantian philosophy as a short path toward his own theory of communicative action. The key challenge was to ground the concept of rational libertywhich Kant defined as the subjects obedience to a self-willed lawin an account of society. G. F. W. Hegel, building on Herders turn to history and culture, identified reason with an objective Spirit unfolding through time. Yet if Hegel took a step forward beyond Kants isolated subject, his valorization of state-imposed morality (Sittlichkeit) was a step back to Christian monarchism. Only Hegels leftwing successors of the 1830s developed a social theory of language to mediate between subject and object. The Young Hegelian Ludwig Feuerbach located the potential for human freedom not in a transcendent God but in everyday social relations, constituted through language.

For Habermas, modern constitutions create the institutional framework for a participatory public sphere, the heart of democratic life. Citizens are bound only by the force of the better argument and can reach agreement across cultural divides.

Habermas titles his last chapter The Contemporaneity of the Young Hegelians, underscoring an enduring shift in the locus of reason from subjective consciousness to intersubjective communication. He dismisses Karl Marxs critique of ideology, which situated the theorist over the heads of the participants themselves. Instead, Habermas regards Charles Sanders Peirce, the founder of American pragmatism, as the true successor to the Young Hegelians. Peirce developed Feuerbachs philosophy of language into a full-fledged theory of knowledge. For Peirce, scientific knowledge obtained solely in intersubjective understandings. Language was the essential medium coordinating between the external world and the research of the scientific community.

Habermas, finally, draws a line to his own writings. Whereas Peirce uncovered linguistic learning processes in science and technology, Habermass own work since the 1980s has shown how communication fosters progress in moral and political life as well. Habermas elects not to engage the late twentieth-century debates that surrounded his corpus. That, he writes, would have required at least one more book. But this decision only contributes to the air of inevitability surrounding This Too a History of Philosophy. Habermass theory of communicative rationality emerges as the outcome of, and explanation for, the trajectory he has traced since the Axial Age. The learning process, it would seem, culminates in its own self-awarenessrealized in Habermass oeuvre.

This brief summary can hardly do justice to the staggering array of texts and debates that Habermas explores. The architecture of the work is ingenious, if its teleology does not fully convince. Most pressing, however, Habermas intends his History not only as a historical exercise, but as a record of the ideas that have furnished the political foundations of the modern West. The work invites readers to consider the resonancesand contradictionsbetween philosophy and politics.

Habermas himself, as in his previous works, sees a close alignment of the two. The normative implications he draws will not surprise veteran readers. A detranscendentalized concept of rational libertythe result of the three-thousand-year dialogue of faith and knowledgeforms the key to a universalist rational morality that makes possible the discursive resolution of moral conflicts, even with a multiplicity of heterogeneous voices. In turn, the historical traces of those moral-practical
learning processes traced over his study are deposited in the practices and legal guarantees of democratic constitutional states. In short, modern constitutions create the institutional framework for a participatory public sphere, the heart of democratic life. Here, citizens are bound only by the force of the better argument and can reach agreement across cultural divides.

A tension persists between Habermass political ideals and his historical framework. His storys European origin collides with its universal intent.

It is an appealing vision. At a time when a global pandemic has only exacerbated spiraling inequalities, pervasive racism, and xenophobic insurgencies on both sides of the Atlantic, Habermas suggests that humanity already possesses the resources for levelheaded debate oriented toward the common good. Yet a tension persists between Habermass political ideals and his historical framework. The gap is not so much one of theory and practice, which Habermas readily acknowledges. Instead, his storys European origin collides with its universal intent. Habermas insists that postmetaphysical reasonbecause it refuses to take refuge in foundational certaintiesprovides a basis for the inter-cultural dialogue necessary to confront global crises of climate change, mass migration, and unregulated markets. But by tracing the emergence of modern rationality solely to a Western, and Christian, learning process, he elides the historical reckoning necessary for any such dialogue.

The same problem faced Habermass Enlightenment precursors, who equally saw Europe as the source of universal ideals. Yet philosophical histories of the German Enlightenment also recognized the role of power in history, and the violence that saturated Europes interactions with the non-European world. Kants 1784 essay Idea for a Universal History with a Cosmopolitan Purpose, which informs Habermass argument for a global public sphere, predicted the achievement of world peace through the improvement in the political constitutions of our continent (which will probably legislate eventually for all other continents). Herder more directly confronted the nexus of European global domination and colonial violence, and suggested that history would have its revenge. Europe must give compensation for the debts that it has incurred, make good the crimes that it has committednot from choice but according to the very nature of things.

Even Hegels history of Absolute Spirit, the most bluntly Eurocentric teleology of classical German Idealism, attests to counter-narratives that shook the self-certainties of revolutionary Europe. As the political theorist Susan Buck-Morss has pointed out, the Haitian Revolution of 17911804, the slave uprising that overthrew French rule over the Caribbean island, may well have motivated Hegels early account of freedom. Though Hegel would later become an apologist for slavery, his dialectical theory of history modeled how political ideals emerge out of struggle, not only consensus. At the same time that Idealist philosophies of history enacted colonialist apologetics, they could also, if inadvertently, subvert them.

This Too a History of Philosophy, by contrast, devotes limited attention to the contradictions of European slavery and colonialism, as well as their problematic treatment by contemporaries. Habermas instead frames colonial encounters as moments in the learning process, way stations on the path toward moral universalism. He addresses the conquest of the Americas only to conclude that Francisco de Vitoria, the sixteenth-century Scholastic who defended the property rights of indigenous peoples, exemplified the universal reach of Catholic natural law. A long section on Lockes theory of natural rights omits their use to justify colonial expropriations.

Haiti, too, is absent from Habermass History, as is the centuries-long, intra-Christian debate over the legitimacy of slavery. Instead, Habermas tells a more straightforward story. The abolition of slavery, he argues, is a popular and really striking example of moral learning:

While the slaves always should have been understood as persons who were denied the social status of free people, the masters first had to learn to recognize and acknowledge in the Other the same person that they were in themselves.

But this description is misleading. It elides not only slaverys enduring legacies, but the histories of resistance, civil war, and violent backlash that paved the twisted road to emancipation. And these histories can hardly be decoupled from the emergence of human rights. Habermas takes the enactment of democratic constitutions to mark the historical embodiment of reason, but the North Atlantic constitutions of the Age of Revolution continued to authorize slavery at the same time that they expanded the rights of privileged groups.

Habermas proceeds similarly through nineteenth- and twentieth-century social reform, passing over the contested, politicized, and still ongoing struggles by which marginalized groups claimed legal rights. Like the abolition of slavery, Habermas regards the authorization of religious tolerance, freedom of opinion, [and] sexual equality, increasingly also the recognition of sexual freedom as the results of moral learning processes. Such learning occurs when

relevant parts of the population discover new connections to other people, toward whom until then they had felt little or only weak obligation . . . allowing them to understand that even these strangers are in no relevant manner different from themselves.

Habermas does not further specify who stands on each side of these learning processes, the active bestowers of rights and the receptive strangers. The implication, however, is that extensions of rights tend to proceed from the moral learning of societys dominant groups.

Habermass account of Western moral progress not only stands apart from classics of critical theory like Horkheimer and Adornos Dialectic of Enlightenment. It is also, arguably, in tension with his own earlier work on the public sphere. In an essay for Habermass ninetieth birthday, the philosopher Mara Pa Lara underscores how Habermass concept of publicity provides tools for feminists and other excluded groups to challenge power structures and demand recognition as political subjects. Yet stories of excluded groups and individuals who inserted themselves into the public sphereand the canon of Western philosophyare all but absent from This Too a History of Philosophy. For its many twists and turns, the history Habermas tells is linear and aggregative, the unfolding of an immanent logic. Rarely do we learn of realizations that were unjustly discarded, knowledge suppressed, experiments failed. In the learning process, it would seem, little is forgotten.

Habermas might object that such a critique misses the point. Painful histories of slavery and colonialism are not at issue, since Western political thought has still come to hold the abolition of racism (or sexism, religious discrimination, or homophobia) as a normative ideal to orient action. And to challenge Habermass conception of the learning process might appear to forfeit the Enlightenment promise of the rational improvement of the human condition.

By tracing the emergence of modern rationality solely to a Western, and Christian, learning process, he elides the historical reckoning necessary for inter-cultural dialogue.

To raise questions of historical accuracy, however, is not to reject Habermass ideals. His goalsconstitutional democracy buttressed by a robust public sphere, equal rights realized in both law and practice, and international cooperation around global problemsremain critically important, even as their attainment appears ever more remote. But a history oriented toward the realization of these ideals would require fuller examination of the contexts under which they were formed and contested. To narrow the genesis of moral universalism to a Western, Christian learning process limits our understanding of how political change happened in the past. Transform
ing the contingent into the inexorable, such a narrative constricts social theorys thinking of possible futures.

Habermas draws to a close with a reference to Theodor Adornos late essay, Reason and Revelation. Reflecting upon on the modern revival of irrational faiths, Adorno concluded that a return to religion could not be sustained. Nothing of theological content will persist without being transformed, Adorno pronounced. Every content will have to put itself to the test of migrating into the realm of the secular, the profane.

Adorno wrote these words in homage to his friend and interlocutor Walter Benjamin, who committed suicide in 1940 fleeing Nazi persecution at the French-Spanish border. Its inclusion is a fitting tribute to Adorno, Habermass teacher and the thinker who articulated the crisis of modern civilization to which Habermass career has responded. And Habermas answers Adorno in a manner fitting of Benjamin, whose late writings perceived the glimmer of messianic hope peering through histories of suffering:

So long as religious experience can still support, on the basis of ritual praxis, the presence of a strong transcendence . . . the question remains open for secular reason whether there are uncompensated semantic contents that still await a translation into the profane.

Religion, Habermas suggests, might retain a sacral core that resists secularization.

Yet Habermass concluding reflection is also jarring, underscoring his departure from the Frankfurt Schools first generation. For Adorno and Benjamin, the experience of brute suffering, epitomized in their own time with the rise of National Socialism, revealed the falsehood of progressive teleologies of human reason. Habermas, by contrast, alludes only once to the historical conditions of his predecessors thought, at the end of a long introduction. Regression, he notes, remains the constant shadow of progress:

What we experienced in the twentieth century as a true break in civilization is anything other than a relapse into barbarism, but the absolutely new, and from now on always present possibility of the moral collapse of an entire nation.

Habermas goes on to concede that unreason in history will be a neglected theme in what is to follow. The Nazi period does not reappear.

Set in the context of German history, an implicit premise of Habermass work may well be that the Federal Republic of Germanys democratic transformation, what Habermas earlier termed its unconditional opening toward the West, vindicates the long arc of the learning process. The unreason that preoccupied his forebears, Habermas seems to suggest, should not blind us to the Wests historical achievements. Habermas has been rightly lauded for seeking a way forward beyond his precursors totalizing critique of reason. His own public contributions proved vital to fostering democratic culture in postwar Germany. But Habermass History avoids linking the emergence of Western-cum-universal rationality with systems of violence and dispossession whose legacies are all too visible todayand that also shaped the history of philosophy.

The unreason that preoccupied his forebears, Habermas seems to suggest, should not blind us to the Wests historical achievements.

Still, by any measure, This Too a History of Philosophy is a landmark achievement. The text caps a generative intellectual career, clarifying how Habermas understands the historical and conceptual foundations of his lifelong project. Most significantly, the work will inspire the next cohort of critical theorists to confront anew the problem of philosophys historical ground. Challenges to democracy and struggles for justice in our own moment may belie the conviction that public reason is the sole heritage of the West, or the apex of its historical progress. But thinking with and against Habermas offers powerful tools for reconsidering the place of communicative action in social theory's project of emancipation. Returning to history as a critical lens on the discourse of philosophy, rather than the canvas of its rational development, offers one path forward.

Authors Note: The author would like to thank Liat Spiro for many conversations about the questions treated in this essay.

More:
The Unfinished Project of Enlightenment - Boston Review

Safer and More Efficient Method To Deliver Gene Therapy – Technology Networks

Madison researchers have developed a safer and more efficient way to deliver a promising new method for treating cancer and liver disorders and for vaccination including a COVID-19 vaccine from Moderna Therapeutics that has advanced to clinical trials with humans.

The technology relies on inserting into cells pieces of carefully designed messenger RNA (mRNA), a strip of genetic material that human cells typically transcribe from a persons DNA in order to make useful proteins and go about their business. Problems delivering mRNA safely and intact without running afoul of the immune system have held back mRNA-based therapy, but UWMadison researchers are making tiny balls of minerals that appear to do the trick in mice.

These microparticles have pores on their surface that are on the nanometer scale that allow them to pick up and carry molecules like proteins or messenger RNA, saysWilliam Murphy, a UWMadison professor of biomedical engineering and orthopedics. They mimic something commonly seen in archaeology, when we find intact protein or DNA on a bone sample or an eggshell from thousands of years ago. The mineral components helped to stabilize those molecules for all that time.

Murphy and UWMadison collaborators used the mineral-coated microparticles (MCMs) which are 5 to 10 micrometers in diameter, about the size of a human cell in a series of experiments to deliver mRNA to cells surrounding wounds in diabetic mice. Wounds healed faster in MCM-treated mice, and cells in related experiments showed much more efficient pickup of the mRNA molecules than other delivery methods.

The researchers described their findings today in the journal Science Advances.In a healthy cell, DNA is transcribed into mRNA, and mRNA serves as the instructions the cells machinery uses to make proteins. A strip of mRNA created in a lab can be substituted into the process to tell a cell to make something new. If that something is a certain kind of antigen, a molecule that alerts the immune system to the presence of a potentially harmful virus, the mRNA has done the job of a vaccine.

The UWMadison researchers coded mRNA with instructions directing cell ribosomes to pump out a growth factor, a protein that prompts healing processes that are otherwise slow to unfold or nonexistent in the diabetic mice (and many severely diabetic people).

mRNA is short-lived in the body, though, so to deliver enough to cells typically means administering large and frequent doses in which the mRNA strands are carried by containers made of molecules called cationic polymers.

Oftentimes the cationic component is toxic. The more mRNA you deliver, the more therapeutic effect you get, but the more likely it is that youre going to see toxic effect, too. So, its a trade-off, Murphy says. What we found is when we deliver from the MCMs, we dont see that toxicity. And because MCM delivery protects the mRNA from degrading, you can get more mRNA where you want it while mitigating the toxic effects.

The new study also paired mRNA with an immune-system-inhibiting protein, to make sure the target cells didnt pick the mRNA out as a foreign object and destroy or eject it.

Successful mRNA delivery usually keeps a cell working on new instructions for about 24 hours, and the molecules they produce disperse throughout the body. Thats enough for vaccines and the antigens they produce. To keep lengthy processes like growing replacement tissue to heal skin or organs, the proteins or growth factors produced by the cells need to hang around for much longer.

What weve seen with the MCMs is, once the cells take up the mRNA and start making protein, that protein will bind right back within the MCM particle, Murphy says. Then it gets released over the course of weeks. Were basically taking something that would normally last maybe hours or even a day, and were making it last for a long time.

And because the MCMs are large enough that they dont enter the bloodstream and float away, they stay right where they are needed to keep releasing helpful therapy. In the mice, that therapeutic activity kept going for more than 20 days.

They are made of minerals similar to tooth enamel and bone, but designed to be reabsorbed by the body when theyre not useful anymore, says Murphy, whose work is supported by the Environmental Protection Agency, the National Institutes of Health and the National Science Foundation and a donation from UWMadison alums Michael and Mary Sue Shannon.

We can control their lifespan by adjusting the way theyre made, so they dissolve harmlessly when we want.

The technology behind the microparticles was patented with the help of the Wisconsin Alumni Research Foundation and is licensed to Dianomi Therapeutics, a company Murphy co-founded.

The researchers are now working on growing bone and cartilage and repairing spinal cord injuries with mRNA delivered by MCMs.

Reference: Khalil et al. (2020).Single-dose mRNA therapy via biomaterial-mediated sequestration of overexpressed proteins. Science Advances.DOI: 10.1126/sciadv.aba2422.

This article has been republished from the following materials. Note: material may have been edited for length and content. For further information, please contact the cited source.

Read more here:
Safer and More Efficient Method To Deliver Gene Therapy - Technology Networks

Genetically modified mosquitoes could be released in Florida and Texas beginning this summer silver bullet or jumping the gun? – The Conversation US

This summer, for the first time, genetically modified mosquitoes could be released in the U.S.

On May 1, 2020, the company Oxitec received an experimental use permit from the U.S. Environmental Protection Agency to release millions of GM mosquitoes (labeled by Oxitec as OX5034) every week over the next two years in Florida and Texas. Females of this mosquito species, Aedes aegypti, transmit dengue, chikungunya, yellow fever and Zika viruses. When these lab-bred GM males are released and mate with wild females, their female offspring die. Continual, large-scale releases of these OX5034 GM males should eventually cause the temporary collapse of a wild population.

However, as vector biologists, geneticists, policy experts and bioethicists, we are concerned that current government oversight and scientific evaluation of GM mosquitoes do not ensure their responsible deployment.

Coral reefs that can withstand rising sea temperatures, American chestnut trees that can survive blight and mosquitoes that cant spread disease are examples of how genetic engineering may transform the natural world.

Genetic engineering offers an unprecedented opportunity for humans to reshape the fundamental structure of the biological world. Yet, as new advances in genetic decoding and gene editing emerge with speed and enthusiasm, the ecological systems they could alter remain enormously complex and understudied.

Recently, no group of organisms has received more attention for genetic modification than mosquitoes to yield inviable offspring or make them unsuitable for disease transmission. These strategies hold considerable potential benefits for the hundreds of millions of people impacted by mosquito-borne diseases each year.

Although the EPA approved the permit for Oxitec, state approval is still required. A previously planned release in the Florida Keys of an earlier version of Oxitecs GM mosquito (OX513) was withdrawn in 2018 after a referendum in 2016 indicated significant opposition from local residents. Oxitec has field-trialed their GM mosquitoes in Brazil, the Cayman Islands, Malaysia and Panama.

The public forum on Oxitecs recent permit application garnered 31,174 comments opposing release and 56 in support. The EPA considered these during their review process.

However, it is difficult to assess how EPA regulators weighed and considered public comments and how much of the evidence used in final risk determinations was provided solely by the technology developers.

The closed nature of this risk assessment process is concerning to us.

There is a potential bias and conflict of interest when experimental trials and assessments of ecological risk lack political accountability and are performed by, or in close collaboration with, the technology developers.

This scenario becomes more troubling with a for-profit technology company when cost- and risk-benefit analyses comparing GM mosquitoes to other approaches arent being conducted.

Another concern is that risk assessments tend to focus on only a narrow set of biological parameters such as the potential for the GM mosquito to transmit disease or the potential of the mosquitoes new proteins to trigger an allergic response in people and neglect other important biological, ethical and social considerations.

To address these shortcomings, the Institute for Sustainability, Energy and Environment at University of Illinois Urbana-Champaign convened a Critical Conversation on GM mosquitoes. The discussion involved 35 participants from academic, government and nonprofit organizations from around the world with expertise in mosquito biology, community engagement and risk assessment.

A primary takeaway from this conversation was an urgent need to make regulatory procedures more transparent, comprehensive and protected from biases and conflicts of interest. In short, we believe it is time to reassess risk assessment for GM mosquitoes. Here are some of the key elements we recommend.

First, an official, government-funded registry for GM organisms specifically designed to reproduce in the wild and intended for release in the U.S. would make risk assessments more transparent and accountable. Similar to the U.S. database that lists all human clinical trials, this field trial registry would require all technology developers to disclose intentions to release, information on their GM strategy, scale and location of release and intentions for data collection.

This registry could be presented in a way that protects intellectual property rights, just as therapies entering clinical trials are patent-protected in their registry. The GM organism registry would be updated in real time and made fully available to the public.

Second, a broader set of risks needs to be assessed and an evidence base needs to be generated by third-party researchers. Because each GM mosquito is released into a unique environment, risk assessments and experiments prior to and during trial releases should address local effects on the ecosystem and food webs. They should also probe the disease transmission potential of the mosquitos wild counterparts and ecological competitors, examine evolutionary pressures on disease agents in the mosquito community and track the gene flow between GM and wild mosquitoes.

To identify and assess risks, a commitment of funding is necessary. The U.S. EPAs recent announcement that it would improve general risk assessment analysis for biotechnology products is a good start. But regulatory and funding support for an external advisory committee to review assessments for GM organisms released in the wild is also needed; diverse expertise and local community representation would secure a more fair and comprehensive assessment.

Furthermore, independent researchers and advisers could help guide what data are collected during trials to reduce uncertainty and inform future large-scale releases and risk assessments.

The objective to reduce or even eliminate mosquito-borne disease is laudable. GM mosquitoes could prove to be an important tool in alleviating global health burdens. However, to ensure their success, we believe that regulatory frameworks for open, comprehensive and participatory decision-making are urgently needed.

This article was updated to correct the date that Oxitec withdrew its OX513 trial application to 2018.

[Deep knowledge, daily. Sign up for The Conversations newsletter.]

Read more from the original source:
Genetically modified mosquitoes could be released in Florida and Texas beginning this summer silver bullet or jumping the gun? - The Conversation US

MTOR signaling orchestrates stress-induced mutagenesis, facilitating adaptive evolution in cancer – Science Magazine

How cancer cells adapt to stress

Bacteria adapt to harsh conditions such as antibiotic exposure by acquiring new mutations, a process called stress-induced mutagenesis. Cipponi et al. investigated whether similar programs of mutagenesis play a role in the response of cancer cells to targeted therapies. Using in vitro models of intense drug selection and genome-wide functional screens, the authors found evidence for an analogous process in cancer and showed that it is regulated by the mammalian target of rapamycin (mTOR) signaling pathway. This pathway appears to mediate a stress-related switch to error-prone DNA repair, resulting in the generation of mutations that facilitate the emergence of drug resistance.

Science, this issue p. 1127

In microorganisms, evolutionarily conserved mechanisms facilitate adaptation to harsh conditions through stress-induced mutagenesis (SIM). Analogous processes may underpin progression and therapeutic failure in human cancer. We describe SIM in multiple in vitro and in vivo models of human cancers under nongenotoxic drug selection, paradoxically enhancing adaptation at a competing intrinsic fitness cost. A genome-wide approach identified the mechanistic target of rapamycin (MTOR) as a stress-sensing rheostat mediating SIM across multiple cancer types and conditions. These observations are consistent with a two-phase model for drug resistance, in which an initially rapid expansion of genetic diversity is counterbalanced by an intrinsic fitness penalty, subsequently normalizing to complete adaptation under the new conditions. This model suggests synthetic lethal strategies to minimize resistance to anticancer therapy.

See the rest here:
MTOR signaling orchestrates stress-induced mutagenesis, facilitating adaptive evolution in cancer - Science Magazine

One of the World’s Most Powerful Scientists Believes in Miracles – Scientific American

When I talk to my students aboutthe tempestuous relationship between science and religion, I like to bring up the case of Francis Collins. Early in his career, Collins was a successful gene-hunter, who helped identify genes associated with cystic fibrosis and other disorders. He went on to become one of the worlds most powerful scientists. Since 2009, he has directed the National Institutes of Health, which this year has a budget of over $40 billion. Before that he oversaw the Human Genome Project, one of historys biggest research projects. Collins was an atheist until 1978, when he underwent a conversion experience while hiking in the mountains and became a devout Christian. In his 2006 bestselling bookThe Language of God, Collins declares that he sees no incompatibility between science and religion. The God of the Bible is also the God of the genome, he wrote. He can be worshipped in the cathedral or in the laboratory. Collins just won the$1.3 million Templeton Prize, created in 1972 to promote reconciliation of science and spirituality. (See my posts on the Templeton Foundationhereandhere). This news gives me an excuse to post an interview I carried out with Collins forNational Geographicin 2006, a time whenRichard Dawkins, Daniel Dennett and others were vigorously attacking religion. Below is an edited transcript of my conversation with Collins, which took place in Washington, D.C. I liked Collins, whom I found to be surprisingly unassuming for a man of such high stature. But I was disturbed by our final exchanges, in which he revealed a fatalistic outlook on humanitys future. Collins, it seems, haslots of faith in God but not much in humanity. John Horgan

Horgan:How does it feel to be at the white-hot center of the current debate between science and religion?

Collins:This increasing polarization between extremists on both ends of the atheism and belief spectrum has been heartbreaking to me. If my suggestion that there is a harmonious middle ground puts me at the white-hot center of debate--Hooray! Its maybe a bit overdue.

Horgan:The danger in trying to appeal to people on both sides of a polarized debate is--

Collins:Bombs thrown at you from both directions!

Horgan:Has that happened?

Collins[sighs]: The majority have responded in very encouraging ways. But some of my scientific colleagues argue that its totally inappropriate for a scientist to write about religion, and we already have too much faith in public life in this country. And then I get someverystrongly worded messages from fundamentalists who feel that I have compromised the literal interpretation of Genesis 1 and call me a false prophet. Im diluting the truth and doing damage to the faith.

Horgan:Why do you think the debate has become so polarized?

Collins:It starts with an extreme articulation of a viewpoint on one side of the issue and that then results in a response that is also a little bit too extreme, and the whole thing escalates. Every action demands an equal and opposite reaction. This is one of Newtons laws playing out in an unfortunate public scenario.

Horgan:I must admit that Ive become more concerned lately about the harmful effects of religion because of religious terrorism like 9/11 and the growing power of the religious right in the United States.

Collins:What faith hasnotbeen used by demagogues as a club over somebodys head? Whether it was the Inquisition or the Crusades on the one hand or the World Trade Center on the other? But we shouldnt judge the pure truths of faith by the way they are applied any more than we should judge the pure truth of love by an abusive marriage. We as children of God have been given by God this knowledge of right and wrong, this Moral Law, which I see as a particularly compelling signpost to His existence. But we also have this thing called free will which we exercise all the time to break that law. We shouldnt blame faith for the ways people distort it and misuse it.

Horgan:Isnt the problem when religions say,Thisis the only way to truth? Isnt that what turns religious faith from something beautiful into something intolerant and hateful?

Collins:There is a sad truth there. I think we Christians have been way too ready to define ourselves as members of an exclusive club. I found truth, I found joy, I found peace in that particular conclusion, but I am not in any way suggesting that that is the conclusion everybody else should find. To have anyone say, My truth is purer than yours, that is both inconsistent with what I see in the person of Christ andincrediblyoff-putting. And quick to start arguments and fights and even wars! Look at the story of the Good Samaritan, which is a parable from Jesus himself. Jews would have considered the Samaritan to be a heretic, and yet clearly Christs message is:Thatis the person who did right and was justified in Gods eyes.

Horgan:How can you, as a scientist who looks for natural explanations of things and demands evidence, also believe in miracles, like the resurrection?

Collins:My first struggle was to believe in God. Not a pantheist God who is entirely enclosed within nature, or a Deist God who started the whole thing and then just lost interest, but a supernatural God who is interested in what is happening in our world and might at times choose to intervene. My second struggle was to believe that Christ was divine as He claimed to be. As soon as I got there, the idea that He might rise from the dead became a non-problem. I dont have a problem with the concept that miracles might occasionally occur at moments ofgreatsignificance where there is a message being transmitted to us by God Almighty. But as a scientist I set my standards for miracles very high. And I dont think we should try to convince agnostics or atheists about the reality of faith with claims about miracles that they can easily poke holes in.

Horgan:The problem I have with miracles is not just that they violate what science tells us about how the world works. They also make God seem too capricious. For example, many people believe that if they pray hard enough God will intercede to heal them or a loved one. But does that mean that all those who dont get better arent worthy?

Collins:In my own experience as a physician, I have not seen a miraculous healing, and I dont expect to see one. Also, prayer for me is not a way to manipulate God into doing what we want Him to do. Prayer for me is much more a sense of trying to get into fellowship with God. Im trying to figure out what I should be doing rather than telling Almighty God whatHeshould be doing. Look at the Lords Prayer. It says, Thywill be done. It wasnt, Our Father who are in Heaven, please get me a parking space.

Horgan:Many people have a hard time believing in God because of the problem of evil. If God loves us, why is life filled with so much suffering?

Collins:That isthemost fundamental question that all seekers have to wrestle with. First of all, if our ultimate goal is to grow, learn, discover things about ourselves and things about God, then unfortunately a life of ease is probably not the way to get there. I know I have learned very little about myself or God when everything is going well. Also, a lot of the pain and suffering in the world we cannot lay at Gods feet. God gave us free will, and we may choose to exercise it in ways that end up hurting other people.

Horgan:The physicist Steven Weinberg, who is an atheist, has written about this topic. He asks why six million Jews, including his relatives, had to die in the Holocaust so that the Nazis could exercise their free will.

Collins:If God had to intervene miraculously every time one of us chose to do something evil, it would be a very strange, chaotic, unpredictable world. Free will leads to people doing terrible things to each other. Innocent people die as a result. You cant blame anyone except the evildoers for that. So thats not Gods fault. The harder question is when suffering seems to have come about through no human ill action. A child with cancer, a
natural disaster, a tornado or tsunami. Why would God not prevent those things from happening?

Horgan:Some theologians, such as Charles Hartshorne, have suggested that maybe God isnt fully in control of His creation. The poet Annie Dillard expresses this idea in her phrase God the semi-competent.

Collins:Thats delightful--and probably blasphemous! An alternative is the notion of God being outside of nature and of time and having a perspective of our blink-of-an-eye existence that goes both far back and far forward. In some admittedly metaphysical way, that allows me to say that the meaning of suffering may not always be apparent to me. There can be reasons for terrible things happening that I cannot know.

Horgan:I think youre an agnostic.

Collins:No!

Horgan:You say that, to a certain extent, Gods ways are inscrutable. That sounds like agnosticism.

Collins:Im agnostic about Gods ways. Im not agnostic about God Himself. Thomas Huxley defined agnosticism as not knowing whether God exists or not. Im a believer! I have doubts. As I quote Paul Tillich: Doubt is not the opposite of faith. Its a part of faith. But my fundamental stance is that God is real, God is true.

Horgan:Im an agnostic, and I was bothered when in your book you called agnosticism a copout. Agnosticism doesnt mean youre lazy or dont care. It means you arent satisfied with any answers for what after all are ultimate mysteries.

Collins:That was a putdown that should not apply to earnest agnostics who have considered the evidence and still dont find an answer. I was reacting to the agnosticism I see in the scientific community, which has not been arrived at by a careful examination of the evidence. I went through a phase when I was a casual agnostic, and I am perhaps too quick to assume that others have no more depth than I did.

Horgan:Free will is a very important concept to me, as it is to you. Its the basis for our morality and search for meaning. Dont you worry that science in general and genetics in particularand your work as head of the Genome Project--are undermining belief in free will?

Collins:Youre talking about genetic determinism, which implies that we are helpless marionettes being controlled by strings made of double helices. That is so far away from what we know scientifically! Heredity does have an influence not only over medical risks but also over certain behaviors and personality traits. But look at identical twins, who have exactly the same DNA but often dont behave alike or think alike. They show the importance of learning and experience--and free will. I think we all, whether we are religious or not, recognize that free will is a reality. There are some fringe elements that say, No, its all an illusion, were just pawns in some computer model. But I dont think that carries you very far.

Horgan:What do you think of Darwinian explanations of altruism, or what you callagape, totally selfless love and compassion for someone not directly related to you?

Collins:Its been a little of a just-so story so far. Many would argue that altruism has been supported by evolution because it helps the group survive. But some people sacrifically give of themselves to those who are outside their group and with whom they have absolutely nothing in common. Like Mother Teresa, Oscar Schindler, many others. That is the nobility of humankind in its purist form. That doesnt seem like it can be explained by a Darwinian model, but Im not hanging my faith on this.

Horgan:If only selflessness were more common.

Collins:Well, there you get free will again. It gets in the way.

Horgan:What do you think about the field of neurotheology, which attempts to identify the neural basis of religious experiences?

Collins:I think its fascinating but not particularly surprising. We humans are flesh and blood. So it wouldnt trouble me--if I were to have some mystical experience myself--to discover that my temporal lobe was lit up. Id say, Wow! Thats okay! That doesnt mean that this doesnt have genuine spiritual significance. Those who come at this issue with the presumption that there is nothing outside the natural world will look at this data and say, Ya see? Whereas those who come with the presumption that we are spiritual creatures will go, Cool! There is a natural correlate to this mystical experience! How about that! I think our spiritual nature is truly God-given, and may not be completely limited by natural descriptors.

Horgan:What if this research leads to drugs or devices for artificially inducing religious experiences? Would you consider those experiences to be authentic? You probably heard about the recent report from Johns Hopkins that the psychedelic drug psilocybin triggered spiritual experiences.

Collins:Yes. If you are talking about the ingestion of an exogenous psychoactive substance or some kind of brain-stimulating contraption, that would smack of not being an authentic, justifiable, trust-worthy experience. So that would be a boundary I would want to establish between the authentic and the counterfeit.

Horgan:Some scientists have predicted that genetic engineering may give us superhuman intelligence and greatly extended life spans, and possibly even immortality. We might even engineer our brains so that we dont fear pain or grief anymore. These are possible long-term consequences of the Human Genome Project and other lines of research. If these things happen, what do you think would be the consequences for religious traditions?

Collins:That outcome would trouble me. But were so far away from that reality that its hard to spend a lot of time worrying about it when you consider all the truly benevolent things we could do in the near term. If you get too hung up on the hypotheticals of what night happen in the next several hundred years, then you become paralyzed and you fail to live up to the opportunities to reach out and help people now. That seems to be the most unethical stance we could take.

Horgan:Im really asking, Does religion requires suffering? Could we reduce suffering to the point where we just wont need religion?

Collins:In spite of the fact that we have achieved all of these wonderful medical advances and made it possible to live longer and eradicate diseases, we will probably still figure out ways to argue with each other and sometimes to kill each other, out of our self-righteousness and our determination that we have to be on top. So the death rate will continue to be one per person by one means or another. We may understand a lot about biology, we may understand a lot about how to prevent illness, and we may understand the life span. But I dont think we will figure out how to stop humans from doing bad things to each other. That will always be our greatest and most distressing experience here on this planet, and that will make us long the most, perhaps, for something more.

Further Reading:

In Defense of Disbelief: An Anti-Creed

Can Faith and Science Coexist?

Richard Dawkins Offers Advice for Donald Trump, and Other Wisdom

What Should We Do With Our Visions of Heaven and Hell?

Mind-Body Problems(free online book, also available asKindle e-bookandpaperback).

Go here to read the rest:
One of the World's Most Powerful Scientists Believes in Miracles - Scientific American

The Cell Therapy Industry to 2028: Global Market & Technology Analysis, Company Profiles of 309 Players (170 Involved in Stem Cells) -…

DUBLIN--(BUSINESS WIRE)--The "Cell Therapy - Technologies, Markets and Companies" report from Jain PharmaBiotech has been added to ResearchAndMarkets.com's offering.

The cell-based markets was analyzed for 2018, and projected to 2028. The markets are analyzed according to therapeutic categories, technologies and geographical areas. The largest expansion will be in diseases of the central nervous system, cancer and cardiovascular disorders. Skin and soft tissue repair as well as diabetes mellitus will be other major markets.

The number of companies involved in cell therapy has increased remarkably during the past few years. More than 500 companies have been identified to be involved in cell therapy and 309 of these are profiled in part II of the report along with tabulation of 302 alliances. Of these companies, 170 are involved in stem cells.

Profiles of 72 academic institutions in the US involved in cell therapy are also included in part II along with their commercial collaborations. The text is supplemented with 67 Tables and 25 Figures. The bibliography contains 1,200 selected references, which are cited in the text.

This report contains information on the following:

The report describes and evaluates cell therapy technologies and methods, which have already started to play an important role in the practice of medicine. Hematopoietic stem cell transplantation is replacing the old fashioned bone marrow transplants. Role of cells in drug discovery is also described. Cell therapy is bound to become a part of medical practice.

Stem cells are discussed in detail in one chapter. Some light is thrown on the current controversy of embryonic sources of stem cells and comparison with adult sources. Other sources of stem cells such as the placenta, cord blood and fat removed by liposuction are also discussed. Stem cells can also be genetically modified prior to transplantation.

Cell therapy technologies overlap with those of gene therapy, cancer vaccines, drug delivery, tissue engineering and regenerative medicine. Pharmaceutical applications of stem cells including those in drug discovery are also described. Various types of cells used, methods of preparation and culture, encapsulation and genetic engineering of cells are discussed. Sources of cells, both human and animal (xenotransplantation) are discussed. Methods of delivery of cell therapy range from injections to surgical implantation using special devices.

Cell therapy has applications in a large number of disorders. The most important are diseases of the nervous system and cancer which are the topics for separate chapters. Other applications include cardiac disorders (myocardial infarction and heart failure), diabetes mellitus, diseases of bones and joints, genetic disorders, and wounds of the skin and soft tissues.

Regulatory and ethical issues involving cell therapy are important and are discussed. Current political debate on the use of stem cells from embryonic sources (hESCs) is also presented. Safety is an essential consideration of any new therapy and regulations for cell therapy are those for biological preparations.

Key Topics Covered

Part I: Technologies, Ethics & Regulations

Executive Summary

1. Introduction to Cell Therapy

2. Cell Therapy Technologies

3. Stem Cells

4. Clinical Applications of Cell Therapy

5. Cell Therapy for Cardiovascular Disorders

6. Cell Therapy for Cancer

7. Cell Therapy for Neurological Disorders

8. Ethical, Legal and Political Aspects of Cell therapy

9. Safety and Regulatory Aspects of Cell Therapy

Part II: Markets, Companies & Academic Institutions

10. Markets and Future Prospects for Cell Therapy

11. Companies Involved in Cell Therapy

12. Academic Institutions

13. References

For more information about this report visit https://www.researchandmarkets.com/r/7h12ne

Read more from the original source:
The Cell Therapy Industry to 2028: Global Market & Technology Analysis, Company Profiles of 309 Players (170 Involved in Stem Cells) -...

A Deep Look Into the Guts Hormones – Technology Networks

Researchers from the Hubrecht Institute and Utrecht University generated an in-depth description of the human hormone-producing cells of the gut, in a large collaborative effort with other research teams. These cells are hard to study, as they are very rare and unique to different species of animals. The researchers developed an extensive toolbox to study human hormone-producing cells in tiny versions of the gut grown in the lab, called organoids. These tools allowed them to uncover secrets of the human gut, for example which potential hormones can be made by the gut and how the secretion of these hormones is triggered. These findings offer potential new avenues for the treatment of diseases such as type 2 diabetes and obesity.Did you ever wonder where that sudden feeling of hunger comes from when your empty stomach rumbles? Thousands of hormone-producing cells, or enteroendocrine cells, scattered throughout your stomach and intestine just released millions of tiny vesicles filled with the hunger hormone ghrelin into your bloodstream.

Another effect to these hormones can be to increase the release of insulin from the pancreas, which is especially interesting in patients with type II diabetes. These patients are unable to produce sufficient insulin to stabilize their glucose levels on their own. One of the most successful treatments for type 2 diabetes is actually based on a gut hormone, called GLP1. With this treatment some patients are able to control their blood glucose without the need of insulin injections.

Most of our knowledge on enteroendocrine cells is derived from studies in mice. However, mice have a different diet and are therefore likely to sense other signals from their food. The differences are so striking that the counterparts of some human gut hormones do not even exist in mice.

To be able to study all the specific types of enteroendocrine cells, the researchers used another trick that was recently developed in the group of Hans Clevers. Clevers: "In our lab, we have optimized genetic engineering of organoids. We were therefore able to label the hormones that are made by the enteroendocrine cells in different colors and create a biobank of mini-intestines, called the EEC-Tag biobank, in which different hormones are tagged with different colors." When an enteroendocrine cell starts producing a labeled hormone, that cell will appear in the corresponding color. The researchers can use the EEC-Tag biobank to study ten major hormones and different combinations of these hormones within the same organoid.

Joep Beumer (Hubrecht Institute): "Marking all major gut hormones with colors allows us to selectively collect any subset of enteroendocrine cells and study even the rarest enteroendocrine cell types. Combining the EEC-Tag biobank with other cutting-edge techniques allowed us to gain deep insights into the biology of hormone production in the human intestine."

"With the EEC-Tag biobank we can measure hundreds of cells for each enteroendocrine cell subtype. The resulting atlas is a gold mine full of fascinating relationships between hormones, receptors and other genes used by well-defined subsets of enteroendocrine cells, which opens many new directions for future studies," says Jens Puschhof (Hubrecht Institute).

The key characteristic of enteroendocrine cells are the active hormones they secrete. To directly measure these hormones, the researchers collaborated with the group of Wei Wu at Utrecht University. The researchers in this group are specialists at mass spectrometry, a very sensitive method to identify different molecules. In the collection of molecules produced by the mini-intestines, they found many new molecules for which it was unknown that they are secreted in the intestine. These new molecules may have functions in our bodies' response to food that are so far unknown. This discovery underlines our limited knowledge of the hormones produced in our gut and will inspire more detailed studies into the functions of these molecules.

Wei Wu (Utrecht University): "Gut secretions contain a mix of hormones that can be either active or inactive. For the first time, we characterize this diversity in human mini-intestines, to reveal also if these hormones are processed into active functional pieces. Hormone activation is not determined by genes, but rather by the processing of the hormones afterwards. Therefore, this may also hint at an exciting route of intervention for broad-spectrum applications, such as controlling hunger or treating diabetes."

This article has been republished from the following materials. Note: material may have been edited for length and content. For further information, please contact the cited source.

Read this article:
A Deep Look Into the Guts Hormones - Technology Networks

Cuban interferon proven effective against COVID-19 Cuba Granma – Official voice of the PCC – Granma English

Currently more than 80 countries have expressed interest in acquiring Heberon. Photo: CIGB

Since the appearance, March 11, of the first cases of COVID-19 in Cuba, the countrys Ministry of Public Health (Minsap) has reported that the inclusion of Recombinant Human Interferon Alpha 2b in treatment protocols for these patients has shown positive results.

Details on the effectiveness of the product were presented by Dr. Eulogio Pimentel Vzquez, director of the Center for Genetic Engineering and Biotechnology (CIGB), affiliated with the BioCubaFarma Enterprise Group, where the medication was first produced in the late 1980s.

"The strength of the Cuban health system, and its close ties with the biotechnology and pharmaceutical industries, in our social system that prioritizes the people's health, makes possible the medications availability for all Cubans."

According to Dr. Pimentel, in accordance with the Minsap treatment protocol, this product, in combination with other drugs, is used as soon as a case is confirmed, and not with patients in serious or critical condition.

Data released April 14 shows that 93.4% of patients testing positive for SARS-COV-2 had been treated with Heberon (the commercial name of Recombinant Human Interferon Alpha 2b). Only 5.5% reached serious condition. The mortality rate reported by Minsap on that date was 2.7%, while for patients with whom the drug was used, the rate was 0.9%. On this same date, on the international level, 15 to 20% of patients were reported in serious condition, while the mortality rate was over 6%.

"The data shows that the protocol in our country is effective, and interferon plays a key role in these results."

Referring to the medications use around the world, the doctor noted that important reports of preclinical and clinical evidence have appeared in several countries. One recent scientific article refers to a study conducted in Wuhan, China, regarding its use with medical personnel. Of the individuals included in the study, 2,944 received the drug and 3,387 did not. Fifty percent of those not treated contracted the disease, while there were no cases identified among those who benefited from Cuban interferon.

At this time, more than 80 countries have expressed interest in acquiring Heberon, reflecting confidence in its usefulness in confronting the pandemic.

The rest is here:
Cuban interferon proven effective against COVID-19 Cuba Granma - Official voice of the PCC - Granma English

GAO report Highlights Barriers in Getting Cell Based Meat to Market – vegconomist – the vegan business magazine

tilialucida - stock.adobe.com

A new report from the US Government Accountability Office (GAO) has given insight into how the cell based meat industry is stuck in its R&D phase. The report demonstrates that there is still plenty of mystery in the fledgling industry, as food tech competes to premier and dominate the market from the onset.

The GAO states: Specific information about the technology being used, eventual commercial production methods, and composition of the final products are not yet known. It has found that the technology and methods are still in development and said FDA and USDA do not have clarity about whats going on with the secretive R&D projects.

The report cites the following issues, which we have summarized, as needing further clarity:

Many questions of course remain to be answered at this stage and vegconomist will keep you informed of developments. Although it is still debatable as to how vegan cultured meat really is, it clearly has the potential to drastically reduce the devastating impact of traditional animal farming, and remove animals from the food system.

Related

Originally posted here:
GAO report Highlights Barriers in Getting Cell Based Meat to Market - vegconomist - the vegan business magazine

Facts that China is trying to suppress about origin of COVID-19 – WION

A recently published scientific article states:

Due to the broad-spectrum of research conducted over almost 20 years on bat SARS-CoV [severe acute respiratory syndrome coronaviruses] justified by their potential to spill over from animal to human, a possible synthetic origin by laboratory engineering of SARS-CoV-2 [COVID-19] is a reasonable hypothesis.

China would like that hypothesis erased from the public consciousness.

The Chinese government, the media and some scientists are desperately trying to convince the public that COVID-19 is a naturally-occurring disease, which was transmitted from animals to humans in the Wuhan Seafood Market.

If COVID-19 leaked from a laboratory, the political and economic consequences for China are enormous.

If it was man-made and leaked from a laboratory, the implications are too grim for many to imagine.

The argument that COVID-19 is naturally-occurring is based nearly entirely on a single, but widely-cited Nature Medicine article entitled The Proximal Origin of SAR-CoV-2.

That conclusion stems primarily from a structural analysis comparing COVID-19 with bat and pangolin (scaly anteater) coronaviruses suggesting a natural evolutionary process in which COVID-19 mutated in an animal population and acquired the ability to infect humans.

Such a scenario does occur and it appears to be the origin of a number of animal-borne coronavirus infections in humans.

Based on the evidence provided in the much-cited Nature Medicine article, however, that conclusion is not obvious.

Although COVID-19 bears a striking structural similarity to the bat coronavirus RaTG13, the critical receptor binding domain, which initiates attachment to human cells, is closer to pangolins.

It is highly unlikely that the bat RaTG13 coronavirus and the pangolin coronavirus combined naturally through a process called reassortment because it would require simultaneous infection of the two viruses in the same animal cell.

It could, however, have been accomplished in a laboratory.

As the recently-published scientific article notes, a new chimeric or combined RaTG13-pangolin coronavirus strain could have been created through an artificial recombinant event, using well-established bioengineering methods.

Another possible indication of genetic manipulation is the presence of a furin polybasic cleavage site in COVID-19 as represented by the PRRA amino acid insertion, which does not exist in any of the bat or pangolin close relatives and is completely out of frame compared to the bat RaTG13 and pangolin sequences.

Perhaps not coincidentally, the furin polybasic cleavage site in COVID-19 occurs in the precise location known to enhance pathogenicity and transmissibility in viruses.

Methods for the insertion of a polybasic cleavage site in infectious bronchitis coronavirus have been described by Chinese scientists and that artificial genetic alteration resulted in increased pathogenicity.

In parallel, animal models for the addition of structures important to the function of coronaviruses, called O-linked glycans, have been used by Chinese scientists at the Chongqing Military Medical University, as well as animal models to specifically select for the human angiotensin-converting enzyme-2 receptor, the entry step for COVID-19 infection.

There is no doubt that China has the knowledge and technology to have created COVID-19. Whether that actually was done is yet to be determined and should be undergoing vigorous scientific investigation.

(Disclaimer: The opinions expressed above are the personal views of the author and do not reflect the views of ZMCL)

More here:
Facts that China is trying to suppress about origin of COVID-19 - WION

The Proto-Communist Plan to Resurrect Everyone Who Ever Lived – VICE

Is there anything that can be done to escape the death cult we seem trapped in?

One of the more radical visions for how to organize human society begins with a simple goal: lets resurrect everyone who has ever lived. Nikolai Fedorov, a nineteenth-century librarian and Russian Orthodoxy philosopher, went so far as to call this project the common task of humanity, calling for the living to be rejuvenated, the dead to be resurrected, and space to be colonized specifically to house them. From the 1860s to the 1930s, Fedorovs influence was present throughout the culturehe influenced a generation of Marxists ahead of the Russian Revolution, as well as literary writers like Leo Tolstoy and Fyodor Dostoevsky, whose novel, The Brothers Karamazov, directly engaged with Federov's ideas about resurrection.

After his death, Federovs acolytes consolidated his ideas into a single text, A Philosophy of the Common Task, and created Cosmism, the movement based on his anti-death eschatology. Federov left the technical details to those who would someday create the prerequisite technology, but this did not stop his disciples: Alexander Bogdanov, who founded the Bolsheviks with Lenin, was an early pioneer of blood transfusions in hopes of rejuvenating humanity; Konstantin Tsiolkvosky, an astrophysicist who was the progenitor of Russia's space program, sought to colonize space to house the resurrected dead; and Alexander Chizhevsky, a biophysicist who sought to map out the effects of solar activity on Earth life and behavior, thought his research might help design the ideal society for the dead to return to.

The vast majority of cosmists were, by the 1930s, either murdered or purged by Stalin, muting the influence of their ambitious project but also leaving us with an incomplete body of work about what type of society resurrection requires or will result in, and whether that wouldas some cosmists believe nowbring us closer to the liberation of the species. Now, I think it is obvious thatdespite what todays transhumanists might tell youwe are in no position, now or anytime soon, to resurrect anyone let alone bring back to life the untold billions that have existed across human history and past it into the eons before civilizations dawn.

To be clear, I think cosmism is absolute madness, but I also find it fascinating. With an introduction to Cosmism and its implications, maybe we can further explore the arbitrary and calculated parts of our social and political order that prioritize capital instead of humanity, often for sinister ends.

**

What? Who gets resurrected? And how?

At its core, the Common Task calls for the subordination of all social relations, productive forces, and civilization itself to the single-minded goal of achieving immortality for the living and resurrection for the dead. Cosmists see this as a necessarily universal project for either everyone or no one at all. That constraint means that their fundamental overhaul of society must go a step further in securing a place where evil or ill-intentioned people cant hurt anyone, but also where immortality is freely accessible for everyone.

Its hard to imagine how that worldwhere resources are pooled together for this project, where humans cannot hurt one another, and where immortality is freeis compatible with the accumulation and exploitation that sit at the heart of capitalism. The crisis heightened by coronavirus should make painfully clear to us all that, as J.W. Masonan economist at CUNYrecently put it, we have a system organized around the threat of withholding people's subsistence, and it "will deeply resist measures to guarantee it, even when the particular circumstances make that necessary for the survival of the system itself." Universal immortality, already an optimistic vision, simply cannot happen in a system that relies on perpetual commodification.

Take one small front of the original cosmist project: blood transfusions. In the 1920s, after being pushed out of the Bolshevik party, Bogdanov focused on experimenting with blood transfusions to create a rejuvenation process for humans (theres little evidence they do this). He tried and failed to set up blood banks across the Soviet Union for the universal rejuvenation of the public, dying from complications of a transfusion himself. Today, young blood is offered for transfusion by industrious start-ups, largely to wealthy and eccentric clientsmost notably (and allegedly) Peter Thiel.

In a book of conversations on cosmism published in 2017 titled Art Without Death, the first dialogue between Anton Vidokle and Hito Steyerl, living artists and writers in Berlin, drives home this same point. Vidokle tells Steyerl that he believes Death is capital quite literally, because everything we accumulatefood, energy, raw material, etc.these are all products of death. For him, it is no surprise were in a capitalist death cult given that he sees value as created through perpetual acts of extraction or exhaustion.

Steyerl echoes these concerns in the conversation, comparing the resurrected dead to artificial general intelligences (AGIs), which oligarch billionaires warn pose an existential threat to humanity. Both groups anticipate fundamental reorganizations of human society, but capitalists diverge sharply from cosmists in that their reorganization necessitates more extraction, more exhaustion, and more death. In their conversation, Steyerl tells Vidokle:

Within the AGI Debate, several solutions have been suggested: first to program the AGI so it will not harm humans, or, on the alt-right/fascist end of the spectrum, to just accelerate extreme capitalisms tendency to exterminate humans and resurrect rich people as some sort of high-net-worth robot race.

These eugenicist ideas are already being implemented: cryogenics and blood transfusions for the rich get the headlines, but the breakdown of healthcare in particularand sustenance in generalfor poor people is literally shortening the lives of millions ... In the present reactionary backlash, oligarchic and neoreactionary eugenics are in full swing, with few attempts being made to contain or limit the impact on the living. The consequences of this are clear: the focus needs to be on the living first and foremost. Because if we dont sort out societycreate noncapitalist abundance and so forththe dead cannot be resurrected safely (or, by extension, AGI cannot be implemented without exterminating humankind or only preserving its most privileged parts).

One of the major problems of todays transhumanist movement is that we are currently unable to equally distribute even basic life-extension technology such as nutrition, medicine, and medical care. At least initially, transhumanists vision of a world in which people live forever is one in which the rich live forever, using the wealth theyve built by extracting value from the poor. Todays transhumanism exists largely within a capitalist framework, and the countrys foremost transhumanist, Zoltan Istvan, a Libertarian candidate for president, is currently campaigning on a platform that shutdown orders intended to preserve human life during the coronavirus pandemic are overblown and are causing irrevocable damage to the capitalist economy (Istvan has in the past written extensively for Motherboard, and has also in the past advocated for the abolition of money).

Cosmists were clear in explaining what resurrection would look like in their idealized version of society, even though they were thin on what the technological details would be. Some argue we must not only restructure our civilization, but our bodies so that we can acquire regenerative abilities, alter our metabolic activity so food or shelter are optional, and thus overcome the natural, social, sexual, and other limitations of the species as Arseny Zhilyaev puts it in a later conversation within the book.

Zhilyaev also invokes Federovs conception of a universal museum, a radicalized, expanded, and more inclusive version of the museums we have now as t
he site of resurrection. In our world, the closest example of this universal museum is the digital world which also doubles as an enormous data collector used for anything from commerce to government surveillance. The prospect of being resurrected because of government/corporate surveillance records or Mormon genealogy databases is sinister at best, but Zhilyaevs argumentand the larger one advanced by other cosmistsis that our world is already full of and defined by absurd and oppressive institutions that are hostile to our collective interests, yet still manage to thrive. The options for our digital worlds development have been defined by advertisers, state authorities, telecom companies, deep-pocketed investors, and the likewhat might it look like if we decided to focus instead on literally any other task?

All this brings us to the question of where the immortal and resurrected would go. The answer, for cosmists, is space. In the cosmist vision, space colonization must happen so that we can properly honor our ethical responsibility to take care of the resurrected by housing them on museum planets. If the universal museum looks like a digital world emancipated from the demands of capital returns, then the museum planet is a space saved from the whims of our knock-off Willy Wonkasthe Elon Musks and Jeff Bezos of the world. I am not saying it is a good or fair idea to segregate resurrected dead people to museum planets in space, but this is what cosmists suggested, and its a quainter, more peaceful vision for space than what todays capitalists believe we should do.

For Musk, Mars and other future worlds will become colonies that require space mortgages, are used for resource extraction, or, in some cases, be used as landing spots for the rich once we have completely destroyed the Earth. Bezos, the worlds richest man, says we will have "gigantic chip factories in space where heavy industry is kept off-planet. Beyond Earth, Bezos anticipates humanity will be contained to O'Neill cylinder space colonies. One might stop and consider the fact that while the cosmist vision calls for improving human civilization on Earth before resurrecting the dead and colonizing space, the capitalist vision sees space as the next frontier to colonize and extract stupendous returns fromtrillions of dollars of resource extraction is the goal. Even in space, they cannot imagine humanity without the same growth that demands the sort of material extraction and environmental degradation already despoiling the world. Better to export it to another place (another country, planet, etc.) than fix the underlying system.

Why?

Ostensibly, the why behind cosmism is a belief that we have an ethical responsibility to resurrect the dead, much like we have one to care for the sick or infirm. At a deeper level, however, cosmists not only see noncapitalist abundance as a virtue in of itself, but believe the process of realizing it would offer chances to challenge deep-seated assumptions about humanity that might aid political and cultural forms hostile to the better future cosmists seek.

Vidokle tells Steyerl in their conversation that he sees the path towards resurrection involving expanding the rights of the dead in ways that undermine certain political and cultural forms,

The dead ... dont have any rights in our society: they dont communicate, consume, or vote and so they are not political subjects. Their remains are removed further and further from the cities, where most of the living reside. Culturally, the dead are now largely pathetical comical figures: zombies in movies, he said. Financial capitalism does not care about the dead because they do not produce or consume. Fascism only uses them as a mythical proof of sacrifice. Communism is also indifferent to the dead because only the generation that achieves communism will benefit from it; everyone who died on the way gets nothing.

In another part of their conversation, Steyerl suggests that failing to pursue the cosmist project might cede ground to the right-wing accelerationism already killing millions:

There is another aspect to this: the maintenance and reproduction of life is of course a very gendered technologyand control of this is on a social battleground. Reactionaries try to grab control over lifes production and reproduction by any means: religious, economic, legal, and scientific. This affects womens rights on the one hand, and, on the other, it spawns fantasies of reproduction wrested from female control: in labs, via genetic engineering, etc.

In other words, the failure to imagine and pursue some alternative to this oligarchic project has real-world consequences that not only kill human beings, but undermine the collective agency of the majority of humanity. In order for this narrow minority to rejuvenate and resurrect themselves in a way that preserves their own privilege and power, they will have to sharply curtail the rights and agency of almost every other human being in every other sphere of society.

Elena Shaposhnikova, another artist who appears later in the book, wonders whether the end of deathor the arrival of a project promising to abolish itmight help us better imagine and pursue lives beyond capitalism:

It seems to me that most of us tend to sublimate our current life conditions and all its problems, tragedies, and inequalities, and project this into future scenarios, she said. So while its easy to imagine and represent life in a society without money and with intergalactic travel, the plot invariably defaults to essentialist conflicts of power, heroism, betrayal, revenge, or something along these lines.

In a conversation with Shaposhnikova, Zhilyaev offers that cosmism might help fight the general fear of socialism as he understands it:

According to Marx, or even Lenin, socialism as a goal is associated with something elsewith opportunities of unlimited plurality and playful creativity, wider than those offered by capitalism. ... the universal museum producing eternal life and resurrection for all as the last necessary step for establishing social justice.

In the conversations that this book, cosmism emerges not simply as an ambition to resurrect the dead but to create, for the first time in human history, a civilization committed to egalitarianism and justice. So committed, in fact, that no part of the human experienceincluding deathwould escape the frenzied wake of our restructuring.

Its a nice thought, and something worth thinking about. Ours is not that world but in fact, one that is committed, above all else, to capital accumulation. There will be no resurrection for the deadthere isnt even healthcare for most of the living, after all. Even in the Citadel of Capital, the heart of the World Empire, the belly of the beast, the richest country in human history, most are expected to fend for themselves as massive wealth transfers drain the public treasuries that mightve funded some measure of protection from the pandemic, the economic meltdown, and every disaster lurking just out of sight. And yet, for all our plumage, our death cult still holds true to Adam Smith's observation in The Wealth of Nations: "All for ourselves, and nothing for other people, seems, in every age of the world, to have been the vile maxim of the masters of mankind."

See more here:
The Proto-Communist Plan to Resurrect Everyone Who Ever Lived - VICE