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Category Archives: Genetic Engineering

Is previous hypoglycemia a risk factor for future hypoglycemic episodes?

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PUBLIC RELEASE DATE:

24-Feb-2014

Contact: Vicki Cohn vcohn@liebertpub.com 914-740-2100 Mary Ann Liebert, Inc./Genetic Engineering News

New Rochelle, NY, February 24, 2014The automatic "threshold suspend" (TS) feature of an insulin pump helps prevent life-threatening hypoglycemic events when the device's sensor detects blood glucose concentrations below the preset threshold. However, in individuals with type 1 diabetes who have had previous episodes of hypoglycemia the TS feature may be less effective at preventing subsequent events, according to important new results from the ASPIRE study published in Diabetes Technology & Therapeutics (DTT), a peer-reviewed journal from Mary Ann Liebert, Inc., publishers. The article is available free on the DTT website at http://www.liebertpub.com/DTT.

In the article "Hypoglycemia Begets Hypoglycemia: The Order Effect in the ASPIRE In-Clinic Study," Editor-in-Chief of Diabetes Technology & Therapeutics Satish Garg, MD (Professor of Medicine and Pediatrics at the University of Colorado Denver) and coauthors compared the effects of an automatic insulin pump with TS at a preset sensor threshold to those of continued basal insulin delivery in adults with type 1 diabetes following induced hypoglycemia via overnight fasting and exercise.

The different outcomes seen between the two insulin delivery methods in this crossover study design led the authors to conclude that "By mitigating the duration of hypoglycemic episodes, automatic pump suspension may help to preserve the normal autonomic response to hypoglycemia in patients with type 1 diabetes."

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About the Journal

Diabetes Technology & Therapeutics (DTT) is a monthly peer-reviewed journal that covers new technology and new products for the treatment, monitoring, diagnosis, and prevention of diabetes and its complications. Led by Editor-in-Chief Satish Garg, MD, Professor of Medicine and Pediatrics at the University of Colorado Denver, the Journal covers topics that include noninvasive glucose monitoring, implantable continuous glucose sensors, novel routes of insulin administration, genetic engineering, the artificial pancreas, measures of long-term control, computer applications for case management, telemedicine, the Internet, and new medications. Tables of content and a sample issue may be viewed on the Diabetes Technology & Therapeutics (DTT) website at http://www.liebertpub.com/DTT. DTT is the official journal of the Advanced Technologies & Treatments for Diabetes (ATTD) Conference.

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Is previous hypoglycemia a risk factor for future hypoglycemic episodes?

Does a diet high in carbohydrates increase your risk of dementia?

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PUBLIC RELEASE DATE:

21-Feb-2014

Contact: Vicki Cohn vcohn@liebertpub.com 914-740-2156 Mary Ann Liebert, Inc./Genetic Engineering News

New Rochelle, NY, February 21, 2014Even small increases in blood sugar caused by a diet high in carbohydrates can be detrimental to brain health. Recent reports in medical literature link carbohydrate calorie-rich diets to a greater risk for brain shrinkage, dementia and Alzheimer's disease, impaired cognition, and other disorders. David Perlmutter, MD, best-selling author of Grain Brain, explores this important topic in a provocative interview in Alternative and Complementary Therapies from Mary Ann Liebert, Inc., publishers. The article is available free on the Alternative and Complementary Therapies website.

Dr. Perlmutter, a board-certified neurologist and fellow of the American College of Nutrition, has just been appointed Editor-in-Chief of a new peer-reviewed journal, Brain and Gut, that will debut in summer 2014. The journal will publish leading-edge research dedicated to exploring a whole systems approach to health and disease from the intimate relationship between the brain and the digestive systems.

In the interview "Rethinking Dietary Approaches for Brain Health," Dr. Perlmutter says, "We live with this notion that a calorie is a calorie, but at least in terms of brain health, and I believe for the rest of the body as well, there are very big differences between our sources of calories in terms of the impact on our health. Carbohydrate calories, which elevate blood glucose, are dramatically more detrimental to human physiology, and specifically to human health, than are calories derived from healthful sources of fat."

Dr. Perlmutter will explore how brain health and cognitive function are linked to nutrition in his presentation, "The Care and Feeding of Your Brain," to be delivered at the 2014 Integrative Healthcare Symposium taking place now in New York City.

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About the Journal

Alternative and Complementary Therapies is a bimonthly journal that publishes original articles, reviews, and commentaries evaluating alternative therapies and how they can be integrated into clinical practice. Topics include botanical medicine, vitamins and supplements, nutrition and diet, mind-body medicine, acupuncture and traditional Chinese medicine, Ayurveda, indigenous medicine systems, homeopathy, naturopathy, yoga and meditation, manual therapies, energy medicine, and spirituality and health. Tables of content and a sample issue may be viewed on the Alternative and Complementary Therapies website.

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Does a diet high in carbohydrates increase your risk of dementia?

3-D Printing and Additive Manufacturing: Preview issue of groundbreaking peer-reviewed journal now available

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PUBLIC RELEASE DATE:

21-Feb-2014

Contact: Sophie Mohin smohin@liebertpub.com 914-740-2100 x2254 Mary Ann Liebert, Inc./Genetic Engineering News

New Rochelle, NY, February 20, 2014A new era of manufacturing is upon us. Recent developments in 3D printing and additive manufacturing technologies are set to usher in the next generation of industrial competitiveness. To address the rapid advances and potential of this groundbreaking new technology, Mary Ann Liebert, Inc., publishers has released an exclusive preview issue of our new peer-reviewed journal 3D Printing and Additive Manufacturing (3DP).

Editor-in-Chief Dr. Hod Lipson, Director of Cornell University's Creative Machines Lab at the Sibley School of Mechanical and Aerospace Engineering, and his expert Editorial Board invite you to view this exclusive preview issue. The Journal will explore emerging challenges and opportunities in additive manufacturing, ranging from new developments of processes and materials, to novel applications in new areas, such as health, medicine, and bio-printing.

To maximize the global impact of this important forum, the articles will be translated into Mandarin Chinese and appear alongside the English version.

"This powerful new journal provides a much-needed multidisciplinary forum on the rapidly evolving technologies of 3D printing engineering and additive manufacturing on a global scale," says Dr. Lipson. "3DP provides a much-needed professional forum for professionals interested in 3D printing across diverse fields, to work towards establishing the next industrial revolution. This journal provides biologists, engineers, materials specialists, and computer scientists a common meeting place."

3DP also addresses the important questions surrounding this powerful and growing field, including issues in policy and law, intellectual property, data standards, safety and liability, environmental impact, social, economic, and humanitarian implications, and emerging business models at the industrial and consumer scales.

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Contact: Sophie Mohin, Mary Ann Liebert, Inc., (914) 740-2100, smohin@liebertpub.com

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3-D Printing and Additive Manufacturing: Preview issue of groundbreaking peer-reviewed journal now available

3D Printing and Additive Manufacturing

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PUBLIC RELEASE DATE:

21-Feb-2014

Contact: Sophie Mohin smohin@liebertpub.com 914-740-2100 x2254 Mary Ann Liebert, Inc./Genetic Engineering News

New Rochelle, NY, February 20, 2014A new era of manufacturing is upon us. Recent developments in 3D printing and additive manufacturing technologies are set to usher in the next generation of industrial competitiveness. To address the rapid advances and potential of this groundbreaking new technology, Mary Ann Liebert, Inc., publishers has released an exclusive preview issue of our new peer-reviewed journal 3D Printing and Additive Manufacturing (3DP).

Editor-in-Chief Dr. Hod Lipson, Director of Cornell University's Creative Machines Lab at the Sibley School of Mechanical and Aerospace Engineering, and his expert Editorial Board invite you to view this exclusive preview issue. The Journal will explore emerging challenges and opportunities in additive manufacturing, ranging from new developments of processes and materials, to novel applications in new areas, such as health, medicine, and bio-printing.

To maximize the global impact of this important forum, the articles will be translated into Mandarin Chinese and appear alongside the English version.

"This powerful new journal provides a much-needed multidisciplinary forum on the rapidly evolving technologies of 3D printing engineering and additive manufacturing on a global scale," says Dr. Lipson. "3DP provides a much-needed professional forum for professionals interested in 3D printing across diverse fields, to work towards establishing the next industrial revolution. This journal provides biologists, engineers, materials specialists, and computer scientists a common meeting place."

3DP also addresses the important questions surrounding this powerful and growing field, including issues in policy and law, intellectual property, data standards, safety and liability, environmental impact, social, economic, and humanitarian implications, and emerging business models at the industrial and consumer scales.

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Contact: Sophie Mohin, Mary Ann Liebert, Inc., (914) 740-2100, smohin@liebertpub.com

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3D Printing and Additive Manufacturing

Why are some children more resilient to post-traumatic stress?

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PUBLIC RELEASE DATE:

20-Feb-2014

Contact: Vicki Cohn vcohn@liebertpub.com 914-740-2100 Mary Ann Liebert, Inc./Genetic Engineering News

New Rochelle, NY, February 20, 2014Children exhibit a range of responses to traumatic events such as natural disasters, with some suffering acute traumatic reactions that resolve over time and others experiencing long-term symptoms of post-traumatic stress. Identifying factors that may help predict which youths are at greater risk of more serious disorders and which are likely to be more resilient following a traumatic event can help determine the care and services needed, according to an article in Journal of Child and Adolescent Psychopharmacology (JCAP), a peer-reviewed journal from Mary Ann Liebert, Inc., publishers. The article is part of a special issue on pediatric traumatic stress that is available on the JCAP website.

In the article "Resilience and Trajectories of Post-traumatic Stress Among Youth Exposed to Disaster," Carl Weems, PhD and Rebecca Graham, University of New Orleans, LA, compare post-traumatic stress (PTS) symptoms among children exposed to both hurricanes Katrina and Gustav and describe the different risk factors and coping styles associated with resiliency to PTS.

Guest Editors Judith Cohen, MD, Drexel University, Philadelphia, PA, and Michael Scheeringa, MD, Tulane University, New Orleans, LA, emphasize the importance of recognizing the similarities and differences in how children and adults react to traumatic events, and the effect that family dynamics and caregivers can have on treatment strategies and their outcomes in the Journal's Editorial.

In another article, authors Richard Meiser-Stedman, PhD, et al., MRC Cognition & Brain Sciences Unit, Cambridge, U.K., and King's College and King's College Hospital, London, caution against using certain cognitive strategies aimed at blocking trauma-related memories in adults and adolescents in the article entitled "Thought Control Strategies and Rumination in Youth with Acute Stress Disorder and Post-traumatic Stress Disorder Following Single-Event Trauma."

In "Perceived Parenting Change and Child Posttraumatic Stress Following a Natural Disaster," Vanessa Cobham, PhD and Brett McDermott, MD, University of Queensland, Brisbane, Australia, identify a link between specific parenting practices and increased risk for PTS symptoms among the children in a household following a natural disaster.

Harold S. Koplewicz, MD, Editor-in-Chief of JCAP, and President, Child Mind Institute, New York, NY, states that there is a "palpable shift in the profession towards considering even sub-threshold PTS symptoms a worthy target of intervention in kids who have experienced a possible traumatic event, such as natural disaster or violence. Even children who do not meet specific criteria in terms of how they response to trauma may warrant careand this care can be helpful. This work is of particular importance in light of recent school shootings and natural disasters."

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Why are some children more resilient to post-traumatic stress?

Joseph Glorioso, Ph.D., receives Pioneer Award

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PUBLIC RELEASE DATE:

19-Feb-2014

Contact: Vicki Cohn vcohn@liebertpub.com 914-740-2100 x2156 Mary Ann Liebert, Inc./Genetic Engineering News

New Rochelle, NY, February 19, 2014Joseph C. Glorioso, III, PhD (University of Pittsburgh School of Medicine, PA) devoted much of his research career to developing herpes viruses as efficient vectors for delivering therapeutic genes into cells. In recognition of his leadership and accomplishments, he has received a Pioneer Award from Human Gene Therapy, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers. Human Gene Therapy is commemorating its 25th anniversary by bestowing this honor on the leading 12 Pioneers in the field of cell and gene therapy selected by a blue ribbon panel* and publishing a Pioneer Perspective by each of the award recipients. The Perspective by Dr. Glorioso is available on the Human Gene Therapy website.

As he recounts in his essay "Herpes Simplex Viral Vectors: Late Bloomers with Big Potential," it took 30 years to create broadly applicable HSV vector designs and a useful gene delivery platform. Since herpes simplex virus has a natural affinity for the nervous system, Dr. Glorioso believes that "gene delivery to the brain represents the most important frontier for HSV-mediated gene therapy and provides a unique opportunity to study complex processes such as learning and memory and to treat complex genetic and acquired diseases, including brain degeneration, epilepsy, and cancer."

In addition, says Dr. Glorioso, some herpes viral delivery systems are proving useful for gene transfer in the emerging field of cellular reprogramming to produce stem cells for tissue regeneration.

"Joe began his work in gene therapy early in the development of the field focusing on the very challenging objective of targeting the central nervous system. His work with HSV vectors represents an incredibly elegant blending of basic virology and translational science," says James M. Wilson, MD, PhD, Editor-in-Chief of Human Gene Therapy, and Director of the Gene Therapy Program, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia.

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*The blue ribbon panel of leaders in cell and gene therapy, led by Chair Mary Collins, PhD, MRC Centre for Medical Molecular Virology, University College London selected the Pioneer Award recipients. The Award Selection Committee selected scientists that had devoted much of their careers to cell and gene therapy research and had made a seminal contribution to the field--defined as a basic science or clinical advance that greatly influenced progress in translational research.

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Joseph Glorioso, Ph.D., receives Pioneer Award

Can marijuana protect the immune system against HIV and slow disease progression?

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PUBLIC RELEASE DATE:

18-Feb-2014

Contact: Vicki Cohn vcohn@liebertpub.com 914-740-2100 Mary Ann Liebert, Inc./Genetic Engineering News

New Rochelle, NY, February 18, 2014New evidence that chronic intake of THC, the primary psychoactive ingredient in marijuana, can protect critical immune tissue in the gut from the damaging effects of HIV infection is reported in AIDS Research and Human Retroviruses, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers. The article is available free on the AIDS Research and Human Retroviruses website at http://www.liebertpub.com/aid.

Patricia Molina and coauthors from Louisiana State University Health Sciences Center, New Orleans, report that chronic THC administration was associated with greater survival of T cell populations and reduced overall cell death in the gut in monkeys, which is known to be a key target for simian immunodeficiency virus (HIV) replication and infection-related inflammation. The researchers present their findings in the article "Modulation of Gut-Specific Mechanisms by Chronic 9-Tetrahydrocannabinol Administration in Male Rhesus Macaques Infected with Simian Immunodeficiency Virus: A Systems Biology Analysis." This report provides mechanistic insights into their previous observation that THC administration attenuates disease progression in SIV infected macaques (AIDS Research and Human Retroviruses 2011; 27: 585-592)

"To better treat HIV infection, we need a better understanding of how it causes the disease we call AIDS. We also need alternative approaches to treatment," says Thomas Hope, PhD, Editor-in-Chief of AIDS Research and Human Retroviruses and Professor of Cell and Molecular Biology at the Feinberg School of Medicine, Northwestern University, Chicago, IL. "This study is important because it begins to explain how THC can influence disease progression in SIV-infected macaques. It also reveals a new way to slow disease progression."

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For immediate release

Contact: Vicki Cohn, Mary Ann Liebert, Inc, (914) 740-2100, ext. 2156, vcohn@liebertpub.com

About the Journal

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Can marijuana protect the immune system against HIV and slow disease progression?


  1. Genetic Engineering