PUBLIC RELEASE DATE:

6-Nov-2014

Contact: Kathryn Ryan kryan@liebertpub.com 914-740-2100 Mary Ann Liebert, Inc./Genetic Engineering News @LiebertOnline

New Rochelle, NY, November 6, 2014--Lower-cost 3D printers for the consumer market offer only a limited selection of plastic materials, while industrial additive manufacturing (AM) machines can print parts made of high-performance metals. The application of a novel process called Selective Inhibition Sintering (SIS) in a consumer-priced metal AM machine is described in an article in 3D Printing and Additive Manufacturing, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers. The article is available free on the 3D Printing and Additive Manufacturing website until December 6, 2014.

Payman Torabi, Matthew Petros, and Behrokh Khoshnevis, University of Southern California, Los Angeles, explain this innovative process, present sample parts printed using the technology, and discuss the next steps in research and development in the article "SIS -- The Process for Consumer Metal Additive Manufacturing" The SIS process differs from traditional research in powder sintering, which focuses on enhancing sintering (a process of fusing materials using heat and pressure); instead, SIS prevents sintering in selected regions of each powder layer.

"This technology uses a fundamentally new approach to 3D printing, one that could expand the reach of metal printing," says Editor-in-Chief Hod Lipson, PhD, Professor at Cornell University's Sibley School of Mechanical and Aerospace Engineering, Ithaca, NY.

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About the Journal

3D Printing and Additive Manufacturing is a peer-reviewed journal published quarterly online with Open Access options and in print. Spearheaded by Hod Lipson, PhD, Director of Cornell University's Creative Machines Lab at the Sibley School of Mechanical and Aerospace Engineering, the Journal explores emerging challenges and opportunities ranging from new developments of processes and materials, to new simulation and design tools, and informative applications and case studies. Spanning a broad array of disciplines focusing on novel 3D printing and rapid prototyping technologies, policies, and innovations, the Journal brings together the community to address the challenges and discover new breakthroughs and trends living within this groundbreaking technology. Tables of content and a sample issue may be viewed on the 3D Printing and Additive Manufacturing (http://www.liebertpub.com/3dp) website.

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Novel 3D printing process enables metal additive manufacturing for consumer market

A 9,300-year-old frozen bison mummy has been found in Eastern Siberia, according to a presentation this week at the Society of Vertebrate Paleontologys Annual Meeting in Berlin.

The still-furry beast is one of the most complete frozen mummies ever found. It literally freezes in time the appearance and anatomy of a steppe bison (Bison priscus), whose species went extinct shortly after the end of the Ice Age.

Mummies Faces,Hair-dos, Revealed in 3D: Photos

Its been named the Yukagir bison mummy, after the region where it was found.

The exceptionally good preservation of the Yukagir bison mummy allows direct anatomical comparisons with modern species of bison and cattle, as well as with extinct species of bison that were gone at the Pleistocene-Holocene boundary, co-author Evgeny Maschenko from the Paleontological Institute in Moscow was quoted as saying in a press release.

The remarkable specimen still has its complete brain, heart, blood vessels and digestive system. Some of its organs have significantly shrunk over time, but thats to be expected given its advanced age.

Video: Three Extinct Animals Making a Comeback

The researchers, led by Natalia Serduk of the Russian Academy of Sciences in Moscow, conducted a necropsy on the remains. The investigation determined that the bison showed a relatively normal anatomy. A clue to its demise, however, is a lack of fat around its abdomen. This suggests that the bison died from starvation, but the scientists arent sure of that yet.

Compared to todays bison in America, the Ice Age bison sported much larger horns and a second back hump. Steppe bison like this now-frozen one were commonly featured in Stone Age cave art, often shown being hunted by humans.

Remains for a woolly rhino, a 35,00039,000-year-old horse, and a mammoth were also recently found near the Siberian site where the bison mummy was discovered.

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9,300-Year-Old Bison Mummy Found in Siberia

6- Mutation Genetic Engineering

By: MinDs MFM

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6- Mutation & Genetic Engineering - Video

No one has used genetic engineering to do something beneficial for the environment.

Syracuse, N.Y. -- In the first use of genetic engineering to save a species in the wild, SUNY researchers say they have created a new strain of blight-resistant American chestnut that could restore the majestic tree to the American landscape.

After 25 years of research, a pair of professors at SUNY College of Environmental Science and Forestry say they have used a gene from wheat to create an American chestnut that could withstand the blight that wiped out up to 5 billion of the trees in the United States.

"It is tremendously satisfying to reach this level of success," said ESF professor Chuck Maynard, who worked with fellow professor William Powell to build the blight-resistant tree.

Before the blight nearly wiped out the trees by the 1950s, chestnuts ranged from Florida to Maine and comprised up to 25 percent of Eastern forests. Its rot-resistant wood was an important source of lumber for log cabins and railroad ties for an emerging nation. The nutrient-rich nuts provided food for wildlife and humans; the roasted nuts were so delicious they even inspired a Christmas song.

"The team has accomplished a major goal, the generation of a blight-resistant American chestnut tree," said Dr. Timothy Tschaplinski, a scientist at Oak Ridge National Laboratory, in a statement released by ESF. "The sum total of these efforts is a major step forward for the goal of restoration of American chestnut to the North American landscape."

Genetic engineering has been used to increase production of crops, particularly corn and soybean, and to make medicines such as insulin.

"No one has used genetic engineering to do something beneficial for the environment," Powell said. "This technique can be used for many species of trees that are threatened by disease. It goes beyond the American chestnut."

ESF's American Chestnut Research and Restoration Project has long been one of the leaders in the movement to restore the tree to the landscape.

Developing a blight-resistant chestnut was a long and tedious process. Through trial-and-error, Powell and Maynard tried 30 genes, extracting them and then using bacteria to deliver the genes to individual chestnut cells. Each of those cells had to grow into trees large enough to test for blight resistance. The first attempt took 2.5 years, Powell said.

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Breakthrough at SUNY-ESF: Genetic engineering may save the nearly extinct American chestnut

There is a need for political support across the spectrum for promoting safe and responsible genetic engineering research, said M. S. Swaminathan, chairman, M.S. Swaminathan Research Foundation.

He was addressing students at the 35 annual convocation of Anna University in the city on Wednesday.

Over one lakh students received their degrees in various specialities..

Mr. Swaminathan said that the present moratorium on field trials with recombinant DNA material was a serious handicap.

Agriculture is a State subject and it is very important that agricultural universities and State departments of agriculture are involved in the design and implementation of field trials. It takes nearly 10 years for a new variety to be ready for recommendation to farmers; therefore, speed is of the essence in organising field trials and gathering reliable data on risks and benefits, he said.

He added that public sector research and development institutions should give high priority to the breeding of varieties which can help farmers minimise climate and market risks.

M. Rajaram, vice-chancellor of Anna University, said in addition to imparting education, the university is sensitive to the welfare of society.

The unmanned aerial vehicle, dhaksha, designed and developed by the university, joined the rescue team at Moulivakkam, he said.

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PUBLIC RELEASE DATE:

5-Nov-2014

Contact: Kathryn Ryan kryan@liebertpub.com 914-740-2100 Mary Ann Liebert, Inc./Genetic Engineering News @LiebertOnline

"New Rochelle, NY, November 5, 2014The e-incubator, an innovative miniature incubator that is compatible with magnetic resonance imaging (MRI), enables scientists to grow tissue-engineered constructs under controlled conditions and to study their growth and development in real-time without risk of contamination or damage. Offering the potential to test engineered tissues before human transplantation, increase the success rate of implantation, and accelerate the translation of tissue engineering methods from the lab to the clinic, the novel e-incubator is described in an article in Tissue Engineering, Part C, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers. The article is available free on the Tissue Engineering website at http://online.liebertpub.com/doi/full/10.1089/ten.tec.2014.0273 until December 5, 2014."

"In the article "The e-Incubator: A Magnetic Resonance Imaging-Compatible Mini Incubator" , Shadi Othman, PhD, Karin Wartella, PhD, Vahid Khalilzad Sharghi, and Huihui Xu, PhD, University of Nebraska-Lincoln, present the results of a validation study using the device to culture tissue-engineered bone constructs for 4 weeks. The e-incubator is a standalone unit that automatically detects and regulates internal conditions such as temperature, carbon dioxide levels, and pH via a microcontroller. It performs media exchange to feed the cultures and remove waste products. The current design is compatible with MRI to monitor the constructs without removing them from the incubator. With proper adjustments, compatibility with other imaging technologies including computed tomography (CT) and optical imaging is also possible."

""Calibratable, hands-free tissue development environments are becoming increasingly important for the engineering of implantable tissues," says Tissue Engineering Co-Editor-in-Chief Peter C. Johnson, MD, Vice President, Research and Development, Avery Dennison Medical Solutions of Chicago, IL and President and CEO, Scintellix, LLC, Raleigh, NC. "In this new development, noninvasive imaging modalities are added to the spectrum of sensing and environmental capabilities that heretofore have included temperature, humidity, light, physical force, and electromagnetism. This represents a solid advance for the field.""

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About the Journal

"Tissue Engineering is an authoritative peer-reviewed journal published online with Open Access options and in print in three parts: Part A, the flagship, published 24 times per year; Part B: Reviews, published bimonthly; and Part C: Methods, published 12 times per year. Led by Co-Editors-In-Chief Antonios Mikos, PhD, Louis Calder Professor at Rice University, Houston, TX, and Peter C. Johnson, MD, Vice President, Research and Development, Avery Dennison Medical Solutions of Chicago, IL and President and CEO, Scintellix, LLC, Raleigh, NC, the Journal brings together scientific and medical experts in the fields of biomedical engineering, material science, molecular and cellular biology, and genetic engineering. Tissue Engineering is the official journal of the Tissue Engineering & Regenerative Medicine International Society (TERMIS). Complete tables of content and a sample issue may be viewed on at the Tissue Engineering website at http://www.liebertpub.com/ten. "

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New e-Incubator enables real-time imaging of bioengineered tissues in controlled unit

Supporters of efforts to label GMOs in foods turn out at a rally in Denverin 2013. A ballot measure that would such labels failed to pass by a wide margin Tuesday. Luke Runyon/KUNC/Harvest Public Media hide caption

Supporters of efforts to label GMOs in foods turn out at a rally in Denverin 2013. A ballot measure that would such labels failed to pass by a wide margin Tuesday.

An effort to label genetically modified foods in Colorado failed to garner enough support Tuesday. It's the latest of several state-based GMO labeling ballot measures to fail. UPDATE: A similar measure in Oregon was also defeated by a narrow margin.

Voters in Colorado resoundingly rejected the labeling of foods that contain the derivatives of genetically modified - or GMO crops, with 66 percent voting against, versus 34 percent in favor.

In Oregon the outcome was closer, with fewer than 51 percent voting against the measure. Political ad spending in Oregon was more competitive than in Colorado, where labeling opponents outspent proponents by millions of dollars.

Meanwhile, a proposal in Maui County, Hawaii, skipped the labeling debate altogether. Voters there narrowly approved a moratorium on GMO crop cultivation. The state has been a battleground between biotech firms and food activists. Some Hawaiian farmers grow a variety of papaya genetically engineered to resist a plant virus.

Polling prior to the GMO labeling vote in Colorado was scarce. Polls found Colorado's measure faced an uphill battle in the final weeks before the election. A Suffolk University poll found only 29 percent of registered voters favored the measure, while 49 percent were likely to vote against it. A Denver Post poll was even more damning. According to that poll, 59 percent were opposed to GMO labeling in Colorado, 34 percent in favor.

Colorado's Proposition 105 would've required food companies to label packaged foods with the text "produced with genetic engineering." Oregon's Measure 92 says food labels would need to include the words "genetically engineered." Many processed foods contain soybean oil, corn syrup, refined sugar and cottonseed oil. Those oils and syrups are often derived from GMO crops that farmers have adopted over the last 18 years. Few whole foods, like the ones you see in the produce aisle, are genetically engineered, though some GE varieties of sweet corn, squash and papaya are approved for sale in the U.S.

The failed measures in Colorado and Oregon follow a nationwide trend. Similar ballot questions in California and Washington state were rejected in 2012 and 2013, respectively. This summer, Vermont's governor signed the nation's first GMO labeling requirement into law. It's supposed to take effect in 2016, but a coalition of biotech firms and farmer groups have filed suit to prevent that from happening.

Groups opposed to GMO labeling poured big money into efforts to quash the ballot measures, spending more than $15 million in Colorado alone. In Oregon, opponents of labeling raised more than $18 million, making the ballot measure the most expensive issue campaign in the state's history. Most of that money came from large seed corporations like Monsanto and DuPont Pioneer, and from processed food companies like Pepsi, Land O' Lakes and Smucker's. All of that outside money opened labeling opponents up to criticism of being tied to corporate interests.

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Colorado, Oregon Reject GMO Labeling

BI280 Chapter 10 Genetic Engineering - Part 1 of 1

By: Heidi Bulfer

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BI280 Chapter 10 Genetic Engineering - Part 1 of 1 - Video

BI280 Chapter 10 Genetic Engineering - Part 2 of 2

By: Heidi Bulfer

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BI280 Chapter 10 Genetic Engineering - Part 2 of 2 - Video

Microfluidics Enables Practical Applications of Genetic Engineering:Synthetic Biology Advances

By: MIT Industrial Liaison Program (ILP)

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Microfluidics Enables Practical Applications of Genetic Engineering:Synthetic Biology Advances - Video

The big agribusiness companies have achieved regulatory capture of government agenciesbut not in the way that many people think. At the urging of industry, since the 1980s federal agencies have over-regulated genetically engineered plants, animals and microorganismsat great cost to U.S.-based R&D and, ultimately, to consumers.

Its no secret that although the Internet has vastly enriched our lives in many respects, it has downsidesless interpersonal interaction, more anonymous snarkiness, online harassment and even cyber-stalking.

The net has also made it difficult to stop or correct the promulgation of misinformation, as I have learned to my dismay: A valid observation I made to a New York Times reporter for a 2001 article on the regulation of genetic engineering has been repeatedly taken out of context and misrepresented by activists. It continues to appear anewstill out of context and misconstrued13 years later.

Here is the portion of the original article that is often quoted on anti-genetic engineering websites (such as here and here):

Even longtime Washington hands said that the control this nascent [agbiotech] industry exerted over its own regulatory destinythrough the Environmental Protection Agency, the Agriculture Department and ultimately the Food and Drug Administrationwas astonishing. In this area, the U.S. government agencies have done exactly what big agribusiness has asked them to do and told them to do, said Dr. Henry Miller, a senior research fellow at the Hoover Institution, who was responsible for biotechnology issues at the Food and Drug Administration from 1979 to 1994.

Sounds like a Eureka! moment, right? A former senior regulatorrevealing an egregious example of what economists call regulatory captureagencies that were created to act in the public interest instead advancing the interests of the industry or sector they oversee by implementing too-lenient regulation. (Economics Nobel Laureate George Stigler developed this concept.) Thats what activistsand even somejournalists who failed to do their homeworkwould have you believe.

That excerpt has been misrepresented to imply that companies applying the molecular techniques of genetic engineering to agriculture (the exemplar of which was, and is, Monsanto) wanted, and got, less regulatory scrutiny than was warranted, possibly putting consumers and the environment at risk.

Actually, my statement was intended to convey exactly the opposite, as was clear from verbiage in the article that preceded the passage quoted above:

Although the Reagan administration had been championing deregulation across multiple industries, Monsanto had a different idea: the company wanted its new technology, genetically modified food, to be governed by rules issued in Washingtonand wanted the White House to champion the idea. There were no products at the time, Leonard Guarraia, a former Monsanto executive who attended the [Vice President George H.W.] Bush meeting, recalled in a recent interview. But we bugged him for regulation. We told him that we have to be regulated.

The genetically improved varieties that had been crafted for centuries with older, less precise, less predictable techniques of genetic modification neither needed nor received any government review or imprimatur for field trials or commercialization. Butfor its new varieties crafted with state-of-the art molecular techniques, the big agribusiness companies wanted sui generis regulatory requirements that would be far in excess of what scientific considerations and the principles of sound regulation dictated. And as the Times article related, [T]he White House complied, working behind the scenes to help Monsantolong a political power with deep connections in Washingtonget the regulations that it wanted.

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Lies, Damn Lies And Genetic Engineering

Election judges check signatures on ballots at the Denver Election Headquarters in downtown Denver, November 04, 2014. Closes races in Colorado are drawing a last minute rush to vote on election day. (RJ Sangosti, The Denver Post)

Voters dished up rejection for Proposition 105, labeling of genetically modified foods, with 35 percent of votes counted.

The measure would have required labels for GMOs foods produced with genetic engineering or containing genetically modified ingredients. More than 68 percent of voters said no to labeling.

Most processed foods sold in America include GMO ingredients such as corn syrup, corn oil, soybean crops and sugar.

Supporters of GMO labeling, such as Right to Know Colorado, Whole Foods and Natural Grocers, said it would give consumers a choice about what they serve their families.

It's a label, not a ban, alerting people to an unnatural manipulation of food, they argued.

Opponents of Prop 105 said the measure would create new costs and red tape for farmers, food manufacturers and grocery stores and consequently would run up grocery bills and cost taxpayers millions for the government oversight.

The rest is here:

Colorado Prop 105: GMO food fight won by opponents of labeling

Genetically engineering tumors in mice, a technique that has dominated cancer research for decades, may not replicate important features of cancers caused by exposure to environmental carcinogens, according to a new study led by UC San Francisco scientists. In addition to pointing the way to better understanding of environmental causes of cancer, the findings may help explain why many patients do not benefit from, or develop resistance to, targeted drug therapies.

In the new research, reported November 2, 2014 in the advance online edition of Nature, a team led by UCSF graduate student Peter M.K. Westcott found that chemically induced lung tumors in mice carry hundreds of point mutationsdeleterious alterations of single letters in the genomethat are not present in tumors induced by genetic engineering. The researchers demonstrated that chemically induced tumors display a starkly different mutational landscape even when chemicals cause a tumor-initiating mutation that is identical to that created by direct genetic manipulation.

Since the 1980s, when genetic engineering came along, the mouse model community has been working on genetically engineered canceryou put a gene in or take a gene out, and you get a tumor, said Allan Balmain, PhD, the Barbara Bass Bakar Distinguished Professor in Cancer Genetics at UCSF and senior author of the study. But its only now that were beginning to analyze what has happened between that first engineered change and the ultimate development of an aggressive tumor.

The new work made use of next-generation sequencing (NGS) technology, which allows researchers to analyze the genomic sequence of tumors or of normal tissue letter-by-letter. For the Nature study, the group used a form of NGS known as whole-exome sequencing, which comprehensively analyzes the portion of the genome that contains the code for producing proteins.

The findings dovetail well with those from NGS-based studies of human tumors, such as The Cancer Genome Atlas (TCGA) initiative spearheaded by the National Cancer Institute and National Human Genome Research Institute, which have revealed mutational signatures, some of which can be definitively tied to environmental exposures. For example, distinctive patterns of point mutations are now known to differentiate lung cancer in smokers from that affecting non-smokers.

The results are also consistent with observations that tumors arising in human organs that are most directly exposed to environmental carcinogensthe skin, gastrointestinal system, and lungsare more prone to point mutations than more protected organs such as the brain, breast, and prostate gland.

We humans smoke cigarettes, drink alcohol, and spend too much time in the sun, all of which cause us to accumulate point mutations that are major determinants of the behavior of tumors, especially of how a tumor responds to therapy, said Balmain, co-leader of the Cancer Genetics Program at UCSFs Helen Diller Family Comprehensive Cancer Center. All this heterogeneity is being missed with genetically engineered tumors, because they dont reflect these environmental effects.

But only a very small number of the 25 mutational signatures revealed by NGS in human tumors so far have been convincingly tied to environmental exposures, Balmain said, so there is much to learn. Other very unusual, very specific signatures have been seen in human studies that remain obscure. Theyre like a smoking gunwe know theyre caused by something environmental, but were not sure what.

To date most epidemiological research on environmental causes of cancer has relied on patients and families to recall and document dietary habits, alcohol and tobacco use, or occupational exposures, and the rise of NGS offers an opportunity to approach these questions more rigorously, said Balmain.

To that end, Balmains research group is embarking on a collaboration with the National Institute of Environmental Health Sciences, which maintains a collection of thousands of mouse and rat tumors caused by exposure to suspected human carcinogens. Through NGS analyses of that collection, the research team hopes to find mutational signatures that can be correlated with those seen in human cancer.

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Environmental Carcinogens Leave Distinctive Genetic Imprints in Tumors

Phayronet ltd
Phayronet combines for medical benefits nanotechnology capabilities together with the achievements of genetic engineering. It develops the future direction of biomedical engineering developments....

By: Phayronet Ltd

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Phayronet ltd - Video

Genecoin - a group of young US entrepreneurs are developing a DNA storage service that uses bitcoin technology to encrypt and store the data(Genecoin)

A group of young entrepreneurs from the US is offering to take peoples' sequenced DNA, convert it into data, and then back it up using the cryptocurrency bitcoin to keep it safe for future genetic engineering and even cloning. It's the stuff of dystopian nightmare futures with clone armies marching around demanding bitcoin for your life.

The Genecoinservice will offer users an easy-to-use DNA sampling kit which can be sent back to the startup through the mail. The firm will then perform the necessary DNA tests and then upload the genome data into a bitcoin storage network.

The creators, based in the Pacific Northwest, say that using bitcoin blockchain technology as a storage tool has great potential for the future far beyond being merely a ledger for bitcoin transactions.

"Bitcoin's core innovation is the idea of a blockchain, which is a decentralised ledger. Bitcoin isn't a currency rather it is a protocol for writing to a blockchain, and this opens the door to lots of disruptive software innovations," Genecoin's creators computer science graduates who currently want to remain anonymous told IBTimes UK.

"There are so many use cases for the blockchain, and 'currency' is only the first one. People are working on all sorts of ideas: smart property, proof of existence, assurance contracts, data storage these are all possible with bitcoin."

There are already other companies using this technique, such as Storj.io, a startup aiming to provide a super secure private cloud, but so far none focusing on genomics.

A physical representation of a Bitcoin(Reuters)

But the question is: would anyone really want to store their DNA to be used to make clones of themselves in the future, and will Bitcoin even be around for long enough to make it a reliable storage format?

"Most people think of Bitcoin as a currency but it is much more. Bitcoin stores records of transactions. Imagine if you sent Morse code messages by giving your friends money. If you're clever about it, you can encode data based on how you make those transactions," Genecoin's creators said.

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Genecoin: Bitcoin DNA Backup Could be Used to Forge Your Clone Army

Genetic Engineering - DNA / RNA Probes Part 2 - Anytime Education
DNA probes are small segments of DNA which help to detect the presence of a gene of a long DNA sequence, in a biological systems. These DNA probes are are the most sophisticated and sensitive...

By: James Dundon

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Genetic Engineering - DNA / RNA Probes Part 2 - Anytime Education - Video

Ebola Field Trial in Genetic Engineering Financed by Pentagon?
5 years after the fake with the swine flu: The World Health Organization WHO beats alarm: A fatal virus again threatens the world, this time it is called Ebo...

By: We Don #39;t Vaccinate!

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Ebola Field Trial in Genetic Engineering Financed by Pentagon? - Video

Genetic Engineering and Plastic Surgery in India
Prime Minister Modi #39;s literal interpretation of Hindu Scriptures.

By: Muneeb Haroon

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Genetic Engineering and Plastic Surgery in India - Video

PUBLIC RELEASE DATE:

30-Oct-2014

Contact: Kathryn Ryan kryan@liebertpub.com 914-740-2100 Mary Ann Liebert, Inc./Genetic Engineering News @LiebertOnline

New Rochelle, NY, October 30, 2014Oligonucleotide-based therapeutics present unique challenges when it comes to testing their potential to cause reproductive and developmental harm. New consensus guidelines for toxicity testing that take into consideration the combined chemical and biological characteristics of these novel biopharmaceuticals are presented in Nucleic Acid Therapeutics, a peer-reviewed journal from Mary Ann Liebert, Inc. publishers. The article is available free on the Nucleic Acid Therapeutics website until November 30, 2014.

Joy Cavagnaro, Access BIO (Boyce, VA), Cindy Berman, Berman Consulting (Wayland, MA), Doug Kornbrust, Preclinisight (Reno, NV), Tacey White, Exponent (Philadelphia, PA), Sarah Campion, Pfizer (Groton, CT), and Scott Henry, Isis Pharmaceuticals (Carlsbad, CA), coauthored the white paper that highlights key points to consider in the design of scientifically valid and predictive toxicity studies. The authors summarize the findings of the Reproductive Subcommittee of the Oligonucleotide Safety Working Group (OSWG) in the article "Considerations for Assessment of Reproductive and Developmental Toxicity of Oligonucleotide-Based Therapeutics."

"I highly commend this latest white paper from the OSWG to researchers and regulators alike involved in the development and implementation of oligonucleotide or antisense based interventions," says Executive Editor Graham C. Parker, PhD, The Carman and Ann Adams Department of Pediatrics, Wayne State University School of Medicine, Children's Hospital of Michigan, Detroit, MI.

Nucleic Acid Therapeutics is under the editorial leadership of Co-Editors-in-Chief Bruce A. Sullenger, PhD, Duke Translational Research Institute, Duke University Medical Center, Durham, NC, and C.A. Stein, MD, PhD, City of Hope National Medical Center, Duarte, CA; and Executive Editor Graham C. Parker, PhD.

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About the Journal

Nucleic Acid Therapeutics is an authoritative, peer-reviewed journal published bimonthly in print and online that focuses on cutting-edge basic research, therapeutic applications, and drug development using nucleic acids or related compounds to alter gene expression. Nucleic Acid Therapeutics is the official journal of the Oligonucleotide Therapeutics Society. Complete tables of content and a sample issue may be viewed on the Nucleic Acid Therapeutics website.

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New guidelines for reproductive & developmental toxicity testing of oligonucleotide drugs

PUBLIC RELEASE DATE:

30-Oct-2014

Contact: Kathryn Ryan kryan@liebertpub.com 914-740-2100 Mary Ann Liebert, Inc./Genetic Engineering News @LiebertOnline

Rochelle, NY, October 30, 2014Several companies are developing spacecraft designed to take ordinary citizens, not astronauts, on short trips into space. "Space tourism" and short periods of weightlessness appear to be safe for most individuals according to a series of articles on space biomedicine published in New Space, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers. The articles are available free on the New Space website until November 30, 2014.

James Vanderploeg, MD, MPH and colleagues, University of Texas Medical Branch, Galveston, coauthored an article outlining the research that has been done to identify the risks and challenges involved in human commercial spaceflight. The authors describe the development of wearable biomedical monitoring equipment for spaceflight participants and of a medical and physiological database. In addition, the suthors also discuss topics such as the risk of electromagnetic interference and ionizing radiation to implanted medical devices in the article "The Human Challenges of Commercial Spaceflight: An Overview of Medical Research Conducted by the University of Texas Medical Branch Through the Federal Aviation Administration Center of Excellence."

"One of the most important areas of New Space research is to determine whether there are biomedical conditions that would disqualify ordinary citizens from a short ride to the edge of space. This first rigorous, peer-reviewed work on a broad range of volunteers indicates most people can take that brief trip," concludes Editor-in-Chief of New Space Prof. Scott Hubbard, Stanford University, in the Editorial "Space Biomedicine -- Who Can Travel to the Final Frontier?"

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About the Journal

New Space facilitates and supports the efforts of researchers, engineers, analysts, investors, business leaders, and policymakers to capitalize on the opportunities of commercial space ventures. Spanning a broad array of topics including technological advancements, global policies, and innovative applications, the journal brings the new space community together to address the challenges and discover new breakthroughs and trends in this epoch of private and public/private space discovery. The Journal is published quarterly online with Open Access options and in print. Complete table of contents are available on the New Space website.

About the Publisher

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Is space tourism safe or do civilians risk health effects?