The Era of One-Shot, Multimillion-Dollar Genetic Cures Is Here – WIRED

  1. The Era of One-Shot, Multimillion-Dollar Genetic Cures Is Here  WIRED
  2. Despite Eye-Popping $3.5 Million Price Tag For Gene Therapy Hemgenix, Budget Impact For Most Payers Will Be Relatively Small  Forbes
  3. FDA approves first haemophilia B gene therapy  Nature.com
  4. FDA Approves $3.5 Million Hemophilia B Gene Therapy  BioPharm International
  5. A $3.5M 'bargain'? CSL's hemophilia B drug sets new pricing benchmark, as gene therapy costs mount  MM+M Online
  6. View Full Coverage on Google News

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The Era of One-Shot, Multimillion-Dollar Genetic Cures Is Here - WIRED

Manslaughter Case Has a Strange Twist: Tesla That Killed Couple Was on Autopilot

A court case is about to kick off in Los Angeles later this month, involving a fatal crash caused by a Tesla vehicle, which was on Autopilot.

A provocative manslaughter case is about to kick off in Los Angeles later this month, involving a fatal crash caused by a Tesla vehicle that had the company's controversial Autopilot feature turned on.

It's the first case of its kind, and one that could set a precedent for future crashes involving cars and driver-assistance software, Reuters reports.

We won't know the exact defense until the case gets under way, but the crux is that the man who was behind the wheel of the Tesla is facing manslaughter charges — but has pleaded not guilty, setting up potentially novel legal arguments about culpability in a deadly collision when, technically speaking, it wasn't a human driving the car.

"Who's at fault, man or machine?" asked Edward Walters, an adjunct professor at the Georgetown University, in an interview with Reuters. "The state will have a hard time proving the guilt of the human driver because some parts of the task are being handled by Tesla."

The upcoming trial is about a fatal collision that took place in 2019. The crash involved Kevin George Aziz Riad, who ran a red light in his Tesla Model S, and collided with a Honda Civic, killing a couple who were reportedly on their first date.

According to vehicle data, Riad did not apply the brakes but had a hand on the steering wheel. Perhaps most critically, though, the Tesla's Autopilot feature was turned on in the moments leading up to the crash.

Riad is facing manslaughter charges, with prosecutors arguing his actions were reckless.

Meanwhile, Riad's lawyers have argued that he shouldn't be charged with a crime, but have so far stopped short of publicly placing blame on Tesla's Autopilot software.

Tesla is not directly implicated in the upcoming trial and isn't facing charges in the case, according to Reuters.

A separate trial, however, involving the family of one of the deceased is already scheduled for next year — but this time, Tesla is the defendant.

"I can't say that the driver was not at fault, but the Tesla system, Autopilot, and Tesla spokespeople encourage drivers to be less attentive," the family's attorney Donald Slavik told Reuters.

"Tesla knows people are going to use Autopilot and use it in dangerous situations," he added.

Tesla is already under heavy scrutiny over its Autopilot and so-called Full Self-Driving software, despite conceding that the features "do not make the vehicle autonomous" and that drivers must remain attentive of the road at all times.

Critics argue that Tesla's marketing is misleading and that it's only leading to more accidents — not making the roads safer, as Tesla CEO Elon Musk has argued in the past.

In fact, a recent survey found that 42 percent of Tesla Autopilot said they feel "comfortable treating their vehicles as fully self-driving."

Regulators are certainly already paying attention. The news comes a week after Reuters revealed that the Department of Justice is investigating Tesla over Autopilot.

Last year, the National Highway Traffic Safety Administration (NHTSA) announced an investigation of accidents in which Teslas have smashed into emergency response vehicles that were pulled over with sirens or flares.

This month's trial certainly stands the chance of setting a precedent. Was Riad fully at fault or was Tesla's Autopilot at least partially to blame as well?

The answer now lies in the hands of a jury.

READ MORE: Tesla crash trial in California hinges on question of 'man vs machine' [Reuters]

More on Autopilot: Survey: 42% of Tesla Autopilot Drivers Think Their Cars Can Drive Themselves

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Manslaughter Case Has a Strange Twist: Tesla That Killed Couple Was on Autopilot

There’s Something Strange About How These Stars Are Moving, Scientists Say

Astronomers are puzzled by the strange behavior of a crooked cluster of stars, which appears to be following an alternative theory of gravity.

Astronomers are puzzled by the strange behavior of certain crooked clusters of stars, which appear to be violating our conventional understanding of gravity.

Massive clusters of stars usually are bound together in spirals at the center of galaxies. Some of these clusters fall under a category astrophysicists call open star clusters, which are created in a relatively short period of time as they ignite in a huge cloud of gas.

During this process, loose stars accumulate in a pair of "tidal tails," one of which is being pulled behind, while the other moves ahead.

"According to Newton’s laws of gravity, it’s a matter of chance in which of the tails a lost star ends up," Jan Pflamm-Altenburg of the University of Bonn in Germany, co-author of a new paper published in the Monthly Notices of the Royal Astronomical Society, in a statement. "So both tails should contain about the same number of stars."

But some of their recent observations seemingly defy conventional physics.

"However, in our work we were able to prove for the first time that this is not true," Pflamm-Altenburg added. "In the clusters we studied, the front tail always contains significantly more stars nearby to the cluster than the rear tail."

In fact, their new findings are far more in line with a different theory called "Modified Newtonian Dynamics" (MOND).

"Put simply, according to MOND, stars can leave a cluster through two different doors," Pavel Kroupa, Pflamm-Altenburg's colleague at the University of Bonn and lead author, explained in the statement. "One leads to the rear tidal tail, the other to the front."

"However, the first is much narrower than the second — so it’s less likely that a star will leave the cluster through it," he added. "Newton’s theory of gravity, on the other hand, predicts that both doors should be the same width."

The researchers' simulations, taking MOND into consideration, could explain a lot. For one, they suggest that open star clusters survive a much shorter period of time than what is expected from Newton's laws of physics.

"This explains a mystery that has been known for a long time," Kroupa explained. "Namely, star clusters in nearby galaxies seem to be disappearing faster than they should."

But not everybody agrees that Newton's laws should be replaced with MOND, something that could shake the foundations of physics.

"It’s somewhat promising, but it does not provide completely definitive evidence for MOND," University of Saint Andrews research fellow Indranil Banik told New Scientist. "This asymmetry does make more sense in MOND, but in any individual cluster there could be other effects that are causing it — it’s a bit unlikely that would happen in all of them, though."

The researchers are now trying to hone in on an even more accurate picture by stepping up the accuracy of their simulations, which could either support their MOND theory — or conclude that Newton was, in fact, correct the first time around.

More on star clusters: Something Is Ripping Apart the Nearest Star Cluster to Earth

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There's Something Strange About How These Stars Are Moving, Scientists Say

Greta Thunberg Says UN Climate Conference Is a Scam and She’s Not Attending

The UN's upcoming COP27 climate conference in Egypt is basically a

COP Out

Ever since she lambasted world leaders at a UN conference in 2018 when she was only 15 years old, Swedish environmental activist Greta Thunberg has had the ear of the international community.

Now, Thunberg says she's skipping out on next week's COP27 UN climate summit in Egypt. Why? Because it's rife with "greenwashing."

"I'm not going to COP27 for many reasons, but the space for civil society this year is extremely limited," Thunberg said at a press event for her book, "The Climate Book," as quoted by The Guardian. "The COPs are mainly used as an opportunity for leaders and people in power to get attention, using many different kinds of greenwashing."

Ultimately, in Thunberg's view, the COP conferences "are not really meant to change the whole system" and instead only promote incremental change. Bluntly put, they're feel-good events that don't accomplish much, so she's bowing out.

Wasted Breath

It's not an unfair assessment. For all the pledges made to drastically cut back emissions and achieve net carbon zero by 2050, very few nations have followed through in the short term. And in Europe, the energy crisis in the wake of the war in Ukraine has further sidelined those climate commitments.

So we can't blame her for not going. But it's a bit disheartening that even a tenacious young spokesperson like Thunberg has given up on convincing world leaders at the biggest climate summit in the world.

Maybe it's indicative of the frustrations of her generation at large. When Thunberg was asked what she thought about the recent wave of Just Stop Oil protests that included activists throwing soup on a Van Gogh painting, she said that she viewed what many detractors perceived as a dumb stunt to be symptomatic of the world's failure to effect meaningful environmental change.

"People are trying to find new methods because we realize that what we have been doing up until now has not done the trick," she replied, as quoted by Reuters. "It's only reasonable to expect these kinds of different actions."

Maybe the real question is: if even a UN climate conference isn't the place to get the message out and change hearts, where's the right place, and what's the right way? If the headlines are any indication, zoomers are struggling to figure that out.

More on Greta Thunberg: Greta Thunberg Thinks Germany Shutting Down Its Nuclear Plants Is a Bad Idea

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Greta Thunberg Says UN Climate Conference Is a Scam and She's Not Attending

Twitter Working on Plan to Charge Users to Watch Videos

According to an internal email obtained by The Washington Post, Musk wants to have Twitter charge users to view videos posted by content creators.

Now that Tesla CEO Elon Musk has taken over Twitter, the billionaire has been frantically shuffling through ambitious plans to turn the ailing social media platform into a revenue-driving business.

Case in point, according to internal email obtained by The Washington Post, Musk is plotting for Twitter to charge users to view videos posted by content creators and take a cut of the proceeds — a highly controversial idea that's already been met with internal skepticism.

The team of Twitter engineers has "identified the risk as high" in the email, citing "risks related to copyrighted content, creator/user trust issues, and legal compliance."

In short, Musk is blazing ahead with his infamously ambitious timelines — a "move fast and break things" approach that could signify a tidal change for Twitter's historically sluggish approach to launching new features.

Musk has already made some big structural changes to Twitter, having fired high-up positions at the company and dissolved its board of directors.

The company will also likely be facing mass layoffs, according to The Washington Post.

The new feature detailed in the new email, which is being referred to as "Paywalled Video," allows creators to "enable the paywall once a video has been added to the tweet" and chose from a preset list of prices, ranging from $1 to $10.

"This will also give Twitter a revenue stream to reward content creators," Musk tweeted on Tuesday, adding that "creators need to make a living!"

But whether Twitter users will be willing to pay for stuff that was previously free remains anything but certain.

Musk has already announced that he is planning to charge $8 a month for Twitter users to stay verified, which has been met with derision.

The billionaire CEO is facing an uphill battle. Now that the company is private, he has to pay around $1 billion in annual interest payments, a result from his $44 buyout, according to the WaPo.

Compounding the trouble, Reuters reported last week that Twitter is bleeding some of its most active users.

Meanwhile, Musk's chaotic moves are likely to alienate advertisers, with the Interpublic Group, a massive inter-agency advertising group, recommending that its clients suspend all paid advertising for at least the week.

That doesn't bode well. It's not out of the question that a paywalled video feature may facilitate the monetization of pornographic content, which may end up scaring off advertisers even further — but Twitter's exact intentions for the feature are still unclear.

According to Reuters, around 13 percent of the site's content is currently marked not safe for work (NSFW).

It's part of Musk's attempt to shift revenue away from advertising on the platform. In a tweet last week, he promised advertisers that Twitter wouldn't become a "free-for-all hellscape."

But that hasn't stopped advertisers from already leaving in droves.

All in all, a paywalled video feature could mark a significant departure for Twitter, a platform still primarily known for short snippets of text.

For now, all we can do is watch.

READ MORE: Elon Musk’s Twitter is working on paid-video feature with ‘high’ risk [The Washington Post]

More on Twitter: Elon Musk Pleads With Stephen King to Pay for Blue Checkmark

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Twitter Working on Plan to Charge Users to Watch Videos

This Deepfake AI Singing Dolly Parton’s "Jolene" Is Worryingly Good

Holly Herndon uses her AI twin Holly+ to sing a cover of Dolly Parton's

AI-lands in the Stream

Sorry, but not even Dolly Parton is sacred amid the encroachment of AI into art.

Holly Herndon, an avant garde pop musician, has released a cover of Dolly Parton's beloved and frequently covered hit single, "Jolene." Except it's not really Herndon singing, but her digital deepfake twin known as Holly+.

The music video features a 3D avatar of Holly+ frolicking in what looks like a decaying digital world.

And honestly, it's not bad — dare we say, almost kind of good? Herndon's rendition croons with a big, round sound, soaked in reverb and backed by a bouncy, acoustic riff and a chorus of plaintive wailing. And she has a nice voice. Or, well, Holly+ does. Maybe predictably indie-folk, but it's certainly an effective demonstration of AI with a hint of creative flair, or at least effective curation.

Checking the Boxes

But the performance is also a little unsettling. For one, the giant inhales between verses are too long to be real and are almost cajolingly dramatic. The vocals themselves are strangely even and, despite the somber tone affected by the AI, lack Parton's iconic vulnerability.

Overall, it feels like the AI is simply checking the boxes of what makes a good, swooning cover after listening to Jeff Buckley's "Hallelujah" a million times — which, to be fair, is a pretty good starting point.

Still, it'd be remiss to downplay what Herndon has managed to pull off here, and the criticisms mostly reflect the AI's limited capabilities more than her chops as a musician. The AI's seams are likely intentional, if her previous work is anything to go off of.

Either way, if you didn't know you were listening to an AI from the get-go, you'd probably be fooled. And that alone is striking.

The Digital Self

Despite AI's usually ominous implications for art, Herndon views her experiment as a "way for artists to take control of their digital selves," according to a statement on her website.

"Vocal deepfakes are here to stay," Herndon was quoted saying. "A balance needs to be found between protecting artists, and encouraging people to experiment with a new and exciting technology."

Whether Herndon's views are fatalistic or prudently pragmatic remains to be seen. But even if her intentions are meant to be good for artists, it's still worrying that an AI could pull off such a convincing performance.

More on AI music: AI That Generates Music from Prompts Should Probably Scare Musicians

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This Deepfake AI Singing Dolly Parton's "Jolene" Is Worryingly Good

Scientists Found a Way to Control How High Mice Got on Cocaine

A team of neuroscientists at the University of Wisconsin claim to have found a way to control how high mice can get on cocaine.

A team of neuroscientists at the University of Wisconsin claim to have found a way to control how high mice can get on a given amount of cocaine.

And don't worry — while that may sound like a particularly frivolous plot concocted by a team of evil scientists, the goal of the research is well-meaning.

The team, led by University of Wisconsin neuroscientist Santiago Cuesta, was investigating how the gut microbiome can influence how mice and humans react to ingesting the drug.

The research, detailed in a new paper published this week in the journal Cell Host & Microbe, sheds light on a vicious feedback loop that could explain cases of substance abuse disorders — and possibly lay the groundwork for future therapeutic treatments.

In a number of experiments on mice, the researchers found that cocaine was linked to the growth of common gut bacteria, which feed on glycine, a chemical that facilitates basic brain functions.

The lower the levels of glycine in the brain, the more the mice reacted to the cocaine, exhibiting abnormal behaviors.

To test the theory, the scientists injected the mice with a genetically modified amino acid which cannot break down glycine. As a result, the behavior of mice returned to normal levels.

In other words, the amino acid could curb cocaine addiction-like behaviors — at least in animal models.

"The gut bacteria are consuming all of the glycine and the levels are decreasing systemically and in the brain," said Vanessa Sperandio, senior author, and microbiologist from the University of Wisconsin, in a statement. "It seems changing glycine overall is impacting the glutamatergic synapses that make the animals more prone to develop addiction."

It's an unorthodox approach to treating addiction, but could be intriguing — if it works in people, that is.

"Usually, for neuroscience behaviors, people are not thinking about controlling the microbiota, and microbiota studies usually don't measure behaviors, but here we show they’re connected," Cuesta added. "Our microbiome can actually modulate psychiatric or brain-related behaviors."

In short, their research could lead to new ways of treating various psychiatric disorders such as substance use by adjusting the gut microbiome and not making changes to the brain chemistry.

"I think the bridging of these communities is what's going to move the field forward, advancing beyond correlations towards causations for the different types of psychiatric disorders," Sperandio argued.

READ MORE: How gut bacteria influence the effects of cocaine in mice [Cell Press]

More on addiction: Study: Magic Mushrooms Helped 83% of People Cut Excessive Drinking

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Scientists Found a Way to Control How High Mice Got on Cocaine

Cats May Be Tampering With Crime Scenes, Scientists Say

Cats, ever the mischievous and frisky pets, may be harboring a lot more human DNA than once thought, possibly tampering crime scenes, a new study says.

Cat Burglar

Cats are known for not really minding their own business, getting their furry paws on just about anything they can.

And it turns out, this makes them effective vectors for DNA evidence, according to a study published last month in the journal Forensic Science International: Genetic Supplement Series.

Researchers collaborating with the Victoria Police Forensic Services Department in Australia found detectable human DNA in 80 percent of the samples collected from 20 pet cats, with 70 percent of the samples strong enough that they could be linked to a person of interest in a crime scene investigation.

"Collection of human DNA needs to become very important in crime scene investigations, but there is a lack of data on companion animals such as cats and dogs in their relationship to human DNA transfer," said study lead author Heidi Monkman, a forensic scientist at Flinders University, in a statement.

"These companion animals can be highly relevant in assessing the presence and activities of the inhabitants of the household, or any recent visitors to the scene."

Here Kitty

One possible takeaway is that cats — and other companion pets like dogs — could be harboring DNA that could help solve a case.

The bigger issue, though, is that pets could introduce foreign DNA that muddles a crime scene, possibly leading to an innocent person being implicated. A pet could be carrying the DNA of a complete stranger, or it might bring the DNA of its owner into a crime scene that they had nothing to do with.

Monkman's colleague and co-author of the paper, Maria Goray, is an experienced crime scene investigator and an expert in DNA transfer. She believes their findings could help clear up how pets might tamper a crime scene by carrying outside DNA.

"Are these DNA findings a result of a criminal activity or could they have been transferred and deposited at the scene via a pet?" Goray asked.

It's a question worth asking — especially because innocent people have been jailed off botched DNA science far too often.

More on DNA evidence: Cops Upload Image of Suspect Generated From DNA, Then Delete After Mass Criticism

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Cats May Be Tampering With Crime Scenes, Scientists Say

China Plans to Send Monkeys to Space Station to Have Sex With Each Other

Chinese astronauts are reportedly planning to let monkeys loose on their brand-new space station to have them have sex with each other.

Chinese scientists are reportedly planning to send monkeys to its new Tiangong space station for experiments that will involve the animals mating and potentially reproducing, the South China Morning Post reports.

It's a fascinating and potentially controversial experiment that could have major implications for our efforts to colonize space: can mammals, let alone humans, successfully reproduce beyond the Earth?

According to the report, the experiment would take place in the station's largest capsule, called Wentian, inside two biological test cabinets that can be expanded.

After examining the behavior of smaller creatures, "some studies involving mice and macaques will be carried out to see how they grow or even reproduce in space," Zhang Lu, a researcher at the Chinese Academy of Sciences in Beijing, said during a speech posted to social media earlier this week, as quoted by the SCMP.

"These experiments will help improve our understanding of an organism’s adaptation to microgravity and other space environments," he added.

Some simpler organisms, including nematodes and Japanese rice fish, have been observed reproducing in space.

But more complex life forms have struggled. In 2014, a Russian experiment to see whether geckos could produce offspring in space failed when all the critters died.

And the failure rate for mammals, so far, has been total. Soviet Union scientists got mice to mate during a space flight in 1979, but none of them gave birth after being returned to Earth.

In other words, getting monkeys to reproduce on board a space station will be anything but easy. For one, just dealing with living creatures in space can pose immense challenges. The astronauts will "need to feed them and deal with the waste," Kehkooi Kee, a professor with the school of medicine at Tsinghua University, told the SCMP.

Then there's the fact that astronauts will have to keep the macaques happy and comfortable, something that experts say will be challenging since long term confinement in the spartan environments of space habitats could cause immense stress for the simians.

And even if astronauts successfully set the mood for the monkeys, the physics of sex in space are predicted to be challenging.

"Firstly, just staying in close contact with each other under zero gravity is hard," Adam Watkins, an associate professor of reproductive physiology at University of Nottingham, wrote in a 2020 open letter highlighted by the SCMP. "Secondly, as astronauts experience lower blood pressure while in space, maintaining erections and arousal are more problematic than here on Earth."

With its new space station in nearly full operation, China isn't shying away from asking some big questions — but whether these experiments will play out as expected is anything but certain.

READ MORE: Chinese scientists plan monkey reproduction experiment in space station [South China Morning Post]

More on sex in space: Scientists Say We Really Have to Talk About Boning in Space

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China Plans to Send Monkeys to Space Station to Have Sex With Each Other

NASA Sets Launch Date for Mission to $10 Quintillion Asteroid

After disappointing setbacks and delays, NASA has finally got its mission to an invaluable asteroid made of precious metals back on track.

Rock of Riches

After disappointing setbacks and a delay over the summer, NASA says it's finally reviving its mission to explore a tantalizing and giant space rock lurking deep in the Asteroid Belt.

Known as 16 Psyche, the NASA-targeted asteroid comprises a full one percent of the mass of the Asteroid Bet, and is speculated to be the core of an ancient planet. But Psyche's size isn't what intrigues scientists so much as its metal-rich composition, believed to be harboring a wealth of iron, nickel, and gold worth an estimated $10 quintillion — easily exceeding the worth of the Earth's entire economy. Although, to be clear, they're not interested in the metals' monetary value but rather its possibly planetary origins.

Back On Track

Initially slated to launch in August 2022, NASA's aptly named Psyche spacecraft became plagued with a persistent flight software issue that led the space agency to miss its launch window that closed on October 11.

But after surviving an independent review determining whether the mission should be scrapped or not, NASA has formally announced that its spacecraft's journey to Psyche will be going ahead, planned to launch aboard a SpaceX Falcon Heavy rocket as early as October 10, 2023.

"I'm extremely proud of the Psyche team," said Laurie Leshin, director of NASA's Jet Propulsion Laboratory, in a statement. "During this review, they have demonstrated significant progress already made toward the future launch date. I am confident in the plan moving forward and excited by the unique and important science this mission will return."

Although the new launch date is only a little over a year late, the expected arrival at the asteroid Psyche is set back by over three years — 2029 instead of 2026 — due to having to wait for another opportunity to slingshot off of Mars' gravity.

Peering Into a Planet

Once it arrives, the NASA spacecraft will orbit around the asteroid and probe it with an array of instruments, including a multispectral imager, gamma ray and neutron spectrometers, and a magnetometer, according to the agency.

In doing so, scientists hope to determine if the asteroid is indeed the core of a nascent planet known as a planetesimal. If it is, it could prove to be an invaluable opportunity to understand the interior of terrestrial planets like our own.

More on NASA: NASA Announces Plan to Fix Moon Rocket, and Maybe Launch It Eventually

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NASA Sets Launch Date for Mission to $10 Quintillion Asteroid

Scientists Use Actual Lunar Soil Sample to Create Rocket Fuel

A team of Chinese researchers claim to have turned lunar regolith samples brought back by the country's Chang'e 5 mission into a source of fuel.

Fill 'Er Up

A team of Chinese researchers say they managed to convert actual lunar regolith samples into a source of rocket fuel and oxygen — a potential gamechanger for future space explorers hoping to make use of in-situ resources to fuel up for their return journey.

The researchers found that the lunar soil samples can act as a catalyst to convert carbon dioxide and water from astronauts' bodies and environment into methane and oxygen, as detailed in a paper published in the National Science Review.

"In situ resource utilization of lunar soil to achieve extraterrestrial fuel and oxygen production is vital for the human to carry out Moon exploitation missions," lead author Yujie Xiong said in a new statement about the work. "Considering that there are limited human resources at extraterrestrial sites, we proposed to employ the robotic system to perform the whole electrocatalytic CO2 conversion system setup."

That means we could have a much better shot at carrying out longer duration explorations of the lunar surface in the near future.

Set It, Forget It

According to the paper, which builds on previous research suggesting lunar soil can generate oxygen and fuel, this process can be completed using uncrewed systems, even in the absence of astronauts.

In an experiment, the team used samples from China's Chang'e-5 mission, which landed in Inner Mongolia back in December 2020 — the first lunar soil returned to Earth since 1976.

The Moon soil effectively acted as a catalyst, enabling the electrocatalytic conversion of carbon dioxide into methane and oxygen.

"No significant difference can be observed between the manned and unmanned systems, which further suggests the high possibility of imitating our proposed system in extraterrestrial sites and proves the feasibility of further optimizing catalyst recipes on the Moon," the researchers conclude in their paper.

Liquified

But there's one big hurdle to still overcome: liquifying carbon dioxide is anything but easy given the Moon's frosty atmosphere, as condensing the gas requires a significant amount of heat, as New Scientist reported earlier this year.

Still, it's a tantalizing prospect: an autonomous machine chugging away, pumping out oxygen and fuel for future visitors. But for now, it's not much more than a proof of concept.

READ MORE: Scientists investigate using lunar soils to sustainably supply oxygen and fuels on the moon [Science China Press]

More on lunar soil: Bad News! The Plants Grown in Moon Soil Turned Out Wretched

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Scientists Use Actual Lunar Soil Sample to Create Rocket Fuel

Scientists Spot "Stripped, Pulsating Core" of Star Caused By Horrific Accident

In a

Core Dump

Scientists studying a group of stars made an astonishing but "serendipitous" discovery when they realized that Gamma Columbae, a fairly average celestial body, might actually be the "stripped pulsating core of a massive star," according to a study published this week in Nature Astronomy.

If true, that means Gamma Columbae is missing the envelope, or vast shroud of gas, that hides a star's nuclear fusion powered core.

What caused the stripping of this atmospheric envelope is not definitively known, but the scientists posit that Gamma Columbae running out of hydrogen could've caused its envelope to expand and swallow up a nearby star, likely its binary partner. But in the middle of that relatively common process, something appears to have horrifically gone wrong and ejected the envelope — and possibly even led to the two stars merging.

Naked Core

Before the disaster, the scientists believe Gamma Columbae could have been up to 12 times the mass of our Sun. Now, it's a comparatively meager 5 stellar masses.

Although a naked stellar core missing its envelope has been theorized to exist, it's never been observed in a star this size.

"Having a naked stellar core of such a mass is unique so far," said study co-author Norbert Pryzbilla, head of the Institute for Astro- and Particle Physics at the University of Innsbruck, in an interview with Vice.

Astronomers had an idea of what the cores of massive and low mass stars looked like, Pryzbilla continued, but there wasn't "much evidence" for cores of masses in between.

Star Power

It's an exceedingly rare find because the star is in a "a short-lived post-stripping structural re-adjustment phase" that will only last 10,000 years, according to the study.

That's "long for us humans but in astronomical timescales, very, very short," Przybilla told Vice. "It will always stay as a peculiar object."

The opportunity to study such a rarely exposed stellar core could provide scientists an invaluable look into the evolution of binary star systems. And whatever astronomers learn from the star, it's a fascinating glimpse at stellar destruction at a nearly incomprehensible scale.

More on stars: Black Hole Spotted Burping Up Material Years After Eating a Star

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Scientists Spot "Stripped, Pulsating Core" of Star Caused By Horrific Accident

Elon Musk Meeting With Advertisers, Begging Them Not to Leave Twitter

Advertisers are fleeing Twitter in droves now that Tesla CEO Elon Musk has taken over control. Now, he's trying to pick up the pieces and begging them to return.

Advertisers are fleeing Twitter in droves now that Tesla and SpaceX CEO Elon Musk has taken over control.

Ever since officially closing the $44 billion deal, Musk has been busy gutting the company's executive suite and dissolving its board. Senior executives, as well as Twitter's advertising chief Sarah Personette, have departed as well.

After all, Musk has been very clear about his disdain for advertising for years now.

The resulting uncertainty has advertisers spooked — major advertising holding company IPG has already advised clients to pull out temporarily — and the billionaire CEO is in serious damage mode.

Now, Reuters reports, Musk is spending most of this week meeting with advertisers in New York, trying to reassure them that Twitter won't turn into a "free-for-all hellscape."

According to one of Reuters' sources, the meetings have been "very productive" — but plenty of other marketers are far from satisfied.

Advertisers are reportedly grilling Musk over his plans to address the rampant misinformation being spread on the platform, a trend that Musk himself has been actively contributing to since the acquisition.

And if he's succeeding in ameliorating advertisers in private, he's antagonizing them publicly. On Wednesday, Musk posted a poll asking users whether advertisers should support either "freedom of speech," or "political 'correctness'" — a type of false dichotomy that echoes the rhetoric of far-right conspiracy theorists and conservative pundits.

"Those type of provocations are not helping to calm the waters," an unnamed media buyer told Reuters.

Some are going public with the same sentiment.

"Unless Elon hires new leaders committed to keeping this 'free' platform safe from hate speech, it's not a platform brands can/should advertise on," Allie Wassum, global media director for the Nike-owned shoe brand Jordan, wrote in a LinkedIn post.

So far, Musk's plans for the social media platform remain strikingly muddy. In addition to the behind-the-scenes advertising plays, he's also announced that users will have to pay to retain their verification badge, though he's engaged in a comically public negotiation as to what the cost might be.

He's also hinted that previously banned users — former US president Donald Trump chief among them — might eventually get a chance to return, but only once "we have a clear process for doing so, which will take at least a few more weeks."

The move was seen by many as a way to wait out the impending midterm elections. After all, Twitter has played a huge role in disseminating misinformation and swaying elections in the past.

While advertisers are running for the hills, to Musk advertising is clearly only a small part of the picture — even though historically, social giants like Twitter have struggled to diversify their revenue sources much beyond display ads.

Musk nodded to that reality in a vague open letter posted last week.

"Low relevancy ads are spam, but highly relevant ads are actually content!" he wrote in the note, addressed to "Twitter advertisers."

Big picture, Twitter's operations are in free fall right now and Musk has yet to provide advertisers with a cohesive plan to pick up the pieces.

While he's hinted at the creation of a new content moderation council made up of both "people from all viewpoints" and "wildly divergent views," advertisers are clearly going to be thinking twice about continuing their business with Twitter.

With or without advertising, Twitter's finances are reportedly in a very deep hole. The billions of dollars Musk had to borrow to finance his mega acquisition will cost Twitter around $1 billion a year in interest alone.

The company also wasn't anywhere near profitable before Musk took over, losing hundreds of millions of dollars in a single quarter.

Whether that picture will change any time soon is as unclear as ever, especially in the face of a wintry economy.

But, of course, Musk has proved his critics wrong before. So anything's possible.

READ MORE: Advertisers begin to grill Elon Musk over Twitter 'free-for-all' [Reuters]

More on the saga: Elon Musk Pulling Engineers From Tesla Autopilot to Work on Twitter

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Elon Musk Meeting With Advertisers, Begging Them Not to Leave Twitter

Hackers Just Took Down One of the World’s Most Advanced Telescopes

ALMA is one of the largest and most advanced radio telescopes in the world. And for reasons still unknown to the public, hackers decided to take it down.

Observatory Offline

The Atacama Large Millimeter Array (ALMA) Observatory in Chile has been hit with a cyberattack that has taken its website offline and forced it to suspend all observations, authorities there said.

Even email services were limited in the aftermath, illustrating the broad impact of the hack.

Nested high up on a plateau in the Chilean Andes at over 16,000 feet above sea level, ALMA is one of the most powerful and advanced radio telescopes in the world. Notably, ALMA helped take the first image of a black hole in 2019, in a collaborative effort that linked radio observatories worldwide into forming the Event Horizon Telescope.

Thankfully, ALMA's impressive arsenal of 66 high-precision antennas, each nearly 40 feet in diameter, was not compromised, the observatory said, nor was any of the scientific data those instruments collected.

In High Places

What makes ALMA so invaluable is its specialty in observing the light of the cooler substances of the cosmos, namely gas and dust. That makes ALMA a prime candidate for documenting the fascinating formations of planets and stars when they first emerge amidst clouds of gas.

Since going fully operational in 2013, it's become the largest ground-based astronomical project in the world, according to the European Southern Observatory, ALMA's primary operators.

So ALMA going offline is a distressing development, especially to the thousands of astronomers worldwide that rely on its observations and the some 300 experts working onsite. Getting it up and running is obviously a top priority, but the observatory said in a followup tweet that "it is not yet possible to estimate a date for a return to regular activities."

As of now, there's no information available on who the hackers were, or exactly how they conducted the attack. Their motivations, too, remain a mystery.

More on ALMA: Astronomers Think They Found the Youngest Planet in the Galaxy

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Hackers Just Took Down One of the World's Most Advanced Telescopes

Huge Drone Swarm to Form Giant Advertisement Over NYC Skyline

Someone apparently thought it was a great idea to fly 500 drones over NYC as part of an ad experiment without much warning.

Droning On

Someone thinks it's a great idea to fly 500 drones over New York City to create a huge ad in the sky on Thursday evening. Because New Yorkers certainly don't have any historical reason to mistrust unknown aircraft over their skyline, right?

As Gothamist reports, the drone swarm is part of a "surreal takeover of New York City’s skyline" on behalf of — we shit you not — the mobile game Candy Crush.

Fernanda Romano, Candy Crush's chief marketing officer, told Gothamist that the stunt will "turn the sky into the largest screen on the planet" using the small, light-up drones.

Though this is not the first time the Manhattan skyline has been used as ad space — that distinction goes to the National Basketball Association and State Farm, which did a similar stunt this summer during the NBA draft — local lawmakers are ticked off about it nonetheless.

"I think it’s outrageous to be spoiling our city’s skyline for private profit," Brad Hoylman, a state senator that represents Manhattan's West Side in the NY Legislature, told the local news site. "It’s offensive to New Yorkers, to our local laws, to public safety, and to wildlife."

Freak Out

Indeed, as the NYC Audubon Society noted in a tweet, the Candy Crush crapshoot "could disrupt the flight patterns of thousands of birds flying through NYC, leading to collisions with buildings" as they migrate.

Beyond the harm this will do to birds and the annoyance it will undoubtedly cause the famously-grumpy people of New York, this stunt is also going down with very little warning, considering that Gothamist is one of the only news outlets even reporting on it ahead of time.

While most viewers will hopefully be able to figure out what's going on pretty quickly, the concept of seeing unknown aircraft above the skyline is a little too reminiscent of 9/11 for comfort — and if Candy Crush took that into consideration, they haven't let on.

So here's hoping this event shocks and awes Thursday night city-goers in a good way, and not in the way that makes them panic.

More drone warfare: Russia Accused of Pelting Ukraine Capital With "Kamikaze" Drones

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Huge Drone Swarm to Form Giant Advertisement Over NYC Skyline

US Gov to Crack Down on "Bossware" That Spies On Employees’ Computers

In the era of remote work, employers have turned to invasive

Spying @ Home

Ever since the COVID-19 pandemic drove a wave of working from home, companies have been relentless in their efforts to digitally police and spy on remote employees by using what's known as "bossware." That's the pejorative name for software that tracks the websites an employee visits, screenshots their computer screens, and even records their faces and voices.

And now, the National Labor Relations Board (NLRB), an agency of the federal government, is looking to intervene.

"Close, constant surveillance and management through electronic means threaten employees' basic ability to exercise their rights," said NLRB general counsel Jennifer Abruzzo, in a Monday memo. "I plan to urge the Board to apply the Act to protect employees, to the greatest extent possible, from intrusive or abusive electronic monitoring and automated management practices."

Undoing Unions

In particular, Abruzzo is worried about how bossware could infringe on workers' rights to unionize. It's not hard to imagine how such invasive surveillance could be used to bust unionization. Even if the technology isn't explicitly deployed to impede organization efforts, the ominous presence of the surveillance on its own can be a looming deterrent, which Abruzzo argues is illegal.

And now is the perfect moment for the NLRB to step in. The use and abuse of worker surveillance tech in general — not just bossware — has been "growing by the minute," Mark Gaston Pearce, executive director of the Workers' Rights Institute at Georgetown Law School, told CBS.

"Employers are embracing technology because technology helps them run a more efficient business," Gaston explained. "… What comes with that is monitoring a lot of things that employers have no business doing."

Overbearing Overlord

In some ways, surveillance tech like bossware can be worse than having a nosy, actual human boss. Generally speaking, in a physical workplace employees have an understanding of how much privacy they have (unless they work at a place like Amazon or Walmart, that is).

But when bossware spies on you, who knows how much information an employer could be gathering — or even when they're looking in. And if it surveils an employee's personal computer, which more often than not contains plenty of personal information that a boss has no business seeing, that's especially invasive.

Which is why Abruzzo is pushing to require employers to disclose exactly how much they're tracking.

It's a stern message from the NLRB, but at the end of the day, it's just a memo. We'll have to wait and see how enforcing it pans out.

More on surveillance: Casinos to Use Facial Recognition to Keep "Problem Gamblers" Away

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US Gov to Crack Down on "Bossware" That Spies On Employees' Computers

AOC Says Her Twitter Account Broke After She Made Fun of Elon Musk

Another day, another Elon Musk feud on Twitter — except now, he's the owner of the social network, and he's beefing with AOC.

Latest Feud

Another day, another Elon Musk feud on Twitter — except now, he's the owner of the social network, and he's beefing with a sitting member of Congress.

The whole thing started innocently enough earlier this week, when firebrand Rep. Alexandria Ocasio-Cortez (D-NY, and better known by her initials, "AOC") subtweeted the website's new owner.

"Lmao at a billionaire earnestly trying to sell people on the idea that 'free speech' is actually a $8/mo subscription plan," the New York Democratic Socialist tweeted in a post that, upon Futurism's perusal, appeared to load only half the time.

Sweat Equity

Not one to be shown up, Musk later posted a screenshot of an AOC-branded sweatshirt from the congressperson's website, with its $58 price tag circled and an emoji belying the billionaire's alleged affront at the price.

In response, Ocasio-Cortez said she was proud her sweatshirts were made by union labor, and that the proceeds from their sales were going to fund educational support for needy kids. She later dug in further, noting that her account was "conveniently" not working and joking that Musk couldn't buy his way "out of insecurity."

Yo @elonmusk while I have your attention, why should people pay $8 just for their app to get bricked when they say something you don’t like?

This is what my app has looked like ever since my tweet upset you yesterday. What’s good? Doesn’t seem very free speechy to me ? pic.twitter.com/e3hcZ7T9up

— Alexandria Ocasio-Cortez (@AOC) November 3, 2022

Bricked

To be clear, any suggestion that Musk personally had anything to do with any Twitter glitches on AOC's part would seem ludicrously petty. But then again, this is a guy who once hired a private detective to investigate a random critic.

Occam's razor, though, suggests that it was probably AOC's mega-viral tweet that broke the site's notoriously dodgy infrastructure. Of course, that's not a ringing endorsement of the site that Musk just acquired for the colossal sum of $44 billion.

More on Twitter: Twitter Working on Plan to Charge Users to Watch Videos

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AOC Says Her Twitter Account Broke After She Made Fun of Elon Musk

Chinese Spaceplane Releases Mystery Object Into Orbit

After launching into orbit three months ago, China's top-secret spaceplane has released a mysterious object, which is now circling the Earth behind it.

Spaceplane Buddy

After launching into orbit roughly three months ago, China's top-secret spaceplane has released a mysterious object, which is now circling the Earth behind it, SpaceNews reports.

There's very little we know about China's "reusable experimental spacecraft," except that it launched atop a Long March 2F rocket back in August. We don't know its purpose, what it looks like, or what cargo it was carrying during launch — but it's an intriguing development, nonetheless, for China's reusable launch platform.

Mysterious Object

The object was released between October 24 and October 31, according to tracking data being analyzed by the US Space Force's 18th pace Defense Squadron.

We can only hazard a guess as to what the mysterious object's purpose is. According to Harvard astronomer and space tracker Jonathan McDowell, it "may be a service module, possibly indicating an upcoming deorbit burn."

Based on the size and weight of payloads Long March rockets usually carry, China's mysterious spaceplane is likely similar to the Air Force's X-37B spaceplane, which is similarly shrouded in mystery and currently on its sixth mission.

We also don't know when the Chinese model will make its return back to Earth, but given recent activity at the Lop Nur base in Xinjiang suggests, it may land there in the near future, according to the report.

It's a puzzling new development for China's secretive spacecraft — but it does raise the possibility of a renewed interest in spaceplanes, a potentially affordable and reusable way to launch payloads into orbit.

More on the spaceplane: China Launches Mysterious "Reusable Test" Spacecraft

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Chinese Spaceplane Releases Mystery Object Into Orbit

That "Research" About How Smartphones Are Causing Deformed Human Bodies Is SEO Spam, You Idiots

That

You know that "research" going around saying humans are going to evolve to have hunchbacks and claws because of the way we use our smartphones? Though our posture could certainly use some work, you'll be glad to know that it's just lazy spam intended to juice search engine results.

Let's back up. Today the Daily Mail published a viral story about "how humans may look in the year 3000." Among its predictions: hunched backs, clawed hands, a second eyelid, a thicker skull and a smaller brain.

Sure, that's fascinating! The only problem? The Mail's only source is a post published a year ago by the renowned scientists at... uh... TollFreeForwarding.com, a site that sells, as its name suggests, virtual phone numbers.

If the idea that phone salespeople are purporting to be making predictions about human evolution didn't tip you off, this "research" doesn't seem very scientific at all. Instead, it more closely resembles what it actually is — a blog post written by some poor grunt, intended to get backlinks from sites like the Mail that'll juice TollFreeForwarding's position in search engine results.

To get those delicious backlinks, the top minds at TollFreeForwarding leveraged renders of a "future human" by a 3D model artist. The result of these efforts is "Mindy," a creepy-looking hunchback in black skinny jeans (which is how you can tell she's from a different era).

Grotesque model reveals what humans could look like in the year 3000 due to our reliance on technology

Full story: https://t.co/vQzyMZPNBv pic.twitter.com/vqBuYOBrcg

— Daily Mail Online (@MailOnline) November 3, 2022

"To fully realize the impact everyday tech has on us, we sourced scientific research and expert opinion on the subject," the TollFreeForwarding post reads, "before working with a 3D designer to create a future human whose body has physically changed due to consistent use of smartphones, laptops, and other tech."

Its sources, though, are dubious. Its authority on spinal development, for instance, is a "health and wellness expert" at a site that sells massage lotion. His highest academic achievement? A business degree.

We could go on and on about TollFreeForwarding's dismal sourcing — some of which looks suspiciously like even more SEO spam for entirely different clients — but you get the idea.

It's probably not surprising that the this gambit for clicks took off among dingbats on Twitter. What is somewhat disappointing is that it ended up on StudyFinds, a generally reliable blog about academic research. This time, though, for inscrutable reasons it treated this egregious SEO spam as a legitimate scientific study.

The site's readers, though, were quick to call it out, leading to a comically enormous editor's note appended to the story.

"Our content is intended to stir debate and conversation, and we always encourage our readers to discuss why or why not they agree with the findings," it reads in part. "If you heavily disagree with a report — please debunk to your delight in the comments below."

You heard them! Get debunking, people.

More conspiracy theories: If You Think Joe Rogan Is Credible, This Bizarre Clip of Him Yelling at a Scientist Will Probably Change Your Mind

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That "Research" About How Smartphones Are Causing Deformed Human Bodies Is SEO Spam, You Idiots

Jeff Bezos’ Housekeeper Says She Had to Climb Out the Window to Use the Bathroom

Jeff Bezos' ex- housekeeper is suing him for discrimination that led to her allegedly having to literally sneak out out of his house to use the bathroom.

Jeff Bezos' former housekeeper is suing the Amazon founder for workplace discrimination that she says forced her to literally climb out out the window of his house to use the bathroom.

In the suit, filed this week in a Washington state court, the former housekeeper claimed that she and Bezos' other household staff were not provided with legally-mandated eating or restroom breaks, and that because there was no "readily accessible bathroom" for them to use, they had to clamber out a laundry room window to get to one.

In the complaint, lawyers for the ex-housekeeper, who is described as having worked for wealthy families for nearly 20 years, wrote that household staff were initially allowed to use a small bathroom in the security room of Bezos' main house, but "this soon stopped... because it was decided that housekeepers using the bathroom was a breach of security protocol."

The suit also alleges that housekeepers in the billionaire's employ "frequently developed Urinary Tract Infections" that they believed was related to not being able to use the bathroom when they needed to at work.

"There was no breakroom for the housekeepers," the complaint adds. "Even though Plaintiff worked 10, 12, and sometimes 14 hours a day, there was no designated area for her to sit down and rest."

The housekeeper — who, like almost all of her coworkers, is Latino — was allegedly not aware that she was entitled to breaks for lunch or rest, and was only able to have a lunch break when Bezos or his family were not on the premises, the lawsuit alleges.

The Washington Post owner has denied his former housekeeper's claims of discrimination through an attorney.

"We have investigated the claims, and they lack merit," Harry Korrell, a Bezos attorney, told Insider of the suit. "[The former employee] made over six figures annually and was the lead housekeeper."

He added that the former housekeeper "was responsible for her own break and meal times, and there were several bathrooms and breakrooms available to her and other staff."

"The evidence will show that [the former housekeeper] was terminated for performance reasons," he continued. "She initially demanded over $9M, and when the company refused, she decided to file this suit."

As the suit was just filed and may well end in a settlement, it'll likely be a long time, if ever, before we find out what really happened at Bezos' house — but if we do, it'll be a fascinating peek behind the curtain at the home life of one of the world's most powerful and wealthy men.

More on billionaires: Tesla Morale Low As Workers Still Don't Have Desks, Face Increased Attendance Surveillance

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