BMW Group unveils new logo in India: Brief evolution of BMW logos since 1917 – The Financial Express

BMW Group today introduced its new brand and corporate identity with its new logo and the rollout of its first communication campaign in India called Just Cant Wait. The BMW, BMW i and BMW M communication logos have been reworked with a new logotype. The Group says that the new brand logo delivers on the expectations and visual style of today and is better suited for the digital age. The #JustCantWait campaign is aimed at reflecting the brands customer-centricity and positivity.

BMW has always cherished its relationship with its esteemed customers and has introduced innovative products and value-added services. The new brand design and logo stand for openness and clarity. It symbolises the brands significance and relevance for mobility and driving pleasure in the future, Arlindo Teixeira, acting President, BMW Group India said.

BMW Group India has transformed itself to better serve its existing and new customers needs. With innovative services such as BMW Contactless Experience, BMW Easy Start Plan, BMW Advanced Hygiene Packages and Aftersales service packages, the brand stands true to its promise of offering Sheer Driving Pleasure to customers at all times, he added.

The new logo is much simpler in comparison to the previous one which was three-dimensional. BMW says that the pared-down and two-dimensional design conveys openness and clarity, adding that the change reflects BMWs transition from centering purely on the automotive world to being about technology and connections.

A brief history of BMW logos

The companys origin dates back to 1913 when it specialised in aircraft engines and was called Rapp Motorenwerke. The logo was changed to the first edition of the white & blue logo weve been used to seeing when the company was renamed Bayerische Motoren Werke or BMW in July 1917.

BMW entered the motorcycle market in 1923 with the R32. Its first car was a licensed copy of Austin Seven but by the early 1930s, BMW was producing cars developed in-house and that was also when in 1933 the logo was tweaked with thicker lettering and lines.

Also read:BMW India launches service & maintenance packages: 10-year service, unlimited repair mileage & more

BMW kept the 1933 logo for 20 years before changing it in 1953 bringing it closer to the one we grew up seeing with white lettering on black. This was updated 10 years later to a crisper but still a 2D logo in 1963. The 3D logo was introduced in 1997 and used until 2020. The new logo is back to 2D, is flatter, simpler and loses the dark background signifying transparency.

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BMW Group unveils new logo in India: Brief evolution of BMW logos since 1917 - The Financial Express

UAE Securities And Commodities Authority Hosts Webinar On The Evolution Of Supervisory Technology For Arab Regulators In Collaboration With Arab…

As part of its efforts to promote supervision over the securities sector in the country, the Securities and Commodities Authority (SCA), in collaboration with the Arab Federation of Exchanges (AFE), hosted a joint webinar on the evolution of supervisory technology, or SupTech, for Arab regulators. The webinar, titled Evolution of Supervisory Technology for Capital Markets, was held on June 15, using Microsoft Teams.

Its purpose was to share and exchange international experiences on supervisory technology. Participants in the webinar included representatives from financial market institutions, relevant stakeholders, economic and financial policymakers, in addition to representatives from supervisory and regulatory authorities and international organizations. An elite group of speakers, experts, and specialists in this field participated in the webinar sessions and discussions.

Items on the agenda included welcoming remarks by H.E. Dr. Obaid Al Zaabi,SCAs CEO, Vice Chair of the board of the International Organization of Securities Commissions (IOSCO), and Chair ofIOSCOs Growth and Emerging Markets Committee (GEMC). Richard Cutress delivered a presentation that provided an overview of supervisory technology and presented the perspective of the Financial Conduct Authority (FCA) of the UK.

The webinar included a panel discussion titled Adoption of SupTech and Lessons for Arab Regulators led by Varun Mittal, EY Global Emerging Markets Fintech Leader, and moderated by Mirna Sleiman, Founder and CEO of Fintech Galaxy. It featured panelists, including Narjes Farookh Jamal, Chief Operating Officer at Bahrain Bourse, and Sherif Samy, Chairman of the EgyptianFinTechAssociation and Former Chairman of the Financial Regulatory Authority.

The webinar was concluded with a keynote speech by Rami El Dokany, AFEs Secretary General, while the closing remarks were delivered by Lara Abdulmalak, Unlock Blockchains Editor-in-Chief.

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UAE Securities And Commodities Authority Hosts Webinar On The Evolution Of Supervisory Technology For Arab Regulators In Collaboration With Arab...

Revolution or evolution: has the moment for retail robotics arrived? – eDelivery

Recent weeks have seen automation and robotics start-ups netting new funding from investors, in a sign that retailers may be embracing automation in the wake of the coronavirus disruption.

Locus Robotics, a warehouse robotics company which counts DHL and Boots amongst its customers, netted $40 million in its latest funding round. The funding round, led by funds Zebra Ventures and Scale Venture Partners, brings Locus Robotics total funding to over $105 million.

Logistics robotics company Geek+, which offers robots for services such as cleaning and goods-to-picking, announced last week (18 June) that it had netted $200 million in its most recent funding round.

This has come as major retailers have adopted the technology, with Superdry deploying robots in warehouses in Europe while Gap has introduced them in the US.

Nigel Lahiri, sales director for EMEA at GreyOrange, a robotics company which counts Zalando amongst its customers, says that the pandemic has accelerated adoption of robotics in the logistics space. He highlights predictions that ecommerce will come to take up 40% of total retail (in the US),

Retailers understand that the acceleration [to ecommerce] is going to cause supply chain challenges.

He cites the hugely higher returns rates in online retail compared to physical as well as the generally lower margins available in ecommerce.

Retailers appetite for large-scale capital investments may be dampened by uncertainty about the economy in the wake of the Covid-19 shut-down. This will mean that retailers may deploy robots on a service model, paying a monthly fee rather than gutting their warehouses and buying robots in bulk.

Mark Thomson, director of retail at Zebra Technologies, whose investment arm led the recent funding round into Locus Robotics, says: Retailers dont particularly want to own the hardware why should they own robots? They want that service which robots are providing and the efficiency.

When youre dealing with a service level agreement from the provider you have a much more regular and ongoing conversation rather than a sales or transactional one.

He describes the adoption as an evolutionary rather than revolutionary process.

Its difficult to justify a huge structural investment in CapEx to rekit out, redesign or invest in brand new ones.

With its investment in Locus, Zebra Ventures is backing the cobot model, where robots are installed alongside human workers.

He says that while robots lack the dexterity of humans and cannot easily take over the actual picking and packing process without significant investment, they can take over routine, labour-intensive tasks.

One of these, which Locus specialises in, is robots walking the items from storage over to where they are picked, consolidated and packed.

This improves pick rate per hour without significant changes, making staff much more efficient.

Look at what you already have and look how you can optimise what is already in there, is how Thomson summarises the approach.

Zebra Technologies itself launched its SmartSight solution in January, an automated unit which can move around stores and automate certain processes there, such as making sure products are in the right place and have labels.

The fact that Covid-19 has led to retailers needing to implement social distancing within warehouses only makes the investment case for robots stronger in Thomsons view.

However, Thomson doesnt expect human workforces to disappear far from it.

Staff are not going away weve listened to a number of big retailers who say staff will become more expensive. Theyve actually increased the rates of pay because staff are critical to the customer experience. But they are not great at delivering customer experience if theyre doing these mundane, monotonous, labour-intensive tasks which you can do with automation.

Considering the uncertain economic climate and retailers caution about new technology, we shouldnt expect to see robots everywhere overnight. But as Thomson says, an evolution is taking place to a more hybrid model.

Image: Locus Robotics

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Revolution or evolution: has the moment for retail robotics arrived? - eDelivery

The Whirlwind Path of Human Evolution – The Wire

Art showing stencilled hands (mostly left) in the Cueva de las Manos caves, Argentina, is dated between 11,000-7,000 BC. Photo: Mariano/Wikimedia Commons, CC BY-SA 3.0.

Any story that begins with the words 14 billion years ago is bound to be epic, and Transcendence: How Humans Evolved Through Fire, Language, Beauty, and Time, by Gaia Vince, is no exception. In the first chapter alone, Vince, an award-winning science writer and broadcaster based in London, covers the Big Bang, evolution, photosynthesis, the extinction of the dinosaurs, climate change and the presence of our early primate ancestors on the African savannah. Its a whirlwind and its only the beginning.

By the books conclusion, Vince has taken readers on a journey encompassing tens of thousands of years of human evolution that shows how our exceptional species has reset our relationship with nature and transformed into a new creature from our hypercooperative mass of humanity: we are becoming a superorganism. Vince calls it Homo omnis.

Whether you enjoy this kind of epic treatment of human history might depend on whether you like authors such as Jared Diamond, Stephen Pinker, Bill Bryson, and Yuval Noah Harari, who all write in a similar style: approachable, smart, and very ambitious. (Bryson got there first but nearly all of these authors books could have been called A Short History of Nearly Everything) Transcendence is most comparable to Hararis 2014 blockbuster Sapiens: both offer a sweeping account of human existence beginning with our origin as a species and ending with the idea that our species is becoming something post-human.

Unlike Harari, who focuses on a series of revolutions from the cognitive to the scientific, Vince chooses to highlight more nebulous and even poetic turning points in human evolution like beauty and time. We exist as the result of what she calls an evolutionary triad of genes, environment, and culture, and are now agents of our own transformation. She defines Homo omnis as a species that has transcended our evolutionary purpose to advance our genes for our cultural purpose, which is to be self-determining. Today, we are organisms with options: We can edit our genomes, choose the embryos of our offspring, prolong our lifespans, and maybe one day defeat death itself.

Vince takes care to deftly transition between one subject and another, bringing the reader along as she moves from topics like Wikipedia to cultural evolution to altruism to the neocortex to gossip to the survival of genes to monotheistic religion, as she does in the chapter called Telling. She argues early on that new collaborations between scientific fields, and in particular between the natural and social sciences, has allowed us to look at ourselves with new eyes and recognise the deep links that run through our biology, culture, and environment.

Likewise, Vince assembles the threads of these different disciplines and weaves them together to create moments of revelation for readers. She is uniquely talented in this respect, capable of presenting an impressive breadth of research from palaeoarchaeology to genetics to anthropology. In one of the best chapters, Story, she gives a rich and compelling account of Australian Aboriginal storytelling and the culturally universal strategy of the brain using story as a means to organise information and make it more memorable. Stories are a powerful survival adaptation, writes Vince, because they dont just allow us to travel back in time with our memories, they also allow us to mentally explore different future scenarios without expending time and energy.

Vince offers readers a vertiginous perspective of our existence on the planet. The cumulative effect seems intended to create awe and wonder in the reader, and inspire them to take seriously the responsibility of being an extraordinary species capable of directing our own destiny. But such an approach doesnt leave much room for nuance, and there are many instances when Vince presents readers with statements that would seem to merit greater skepticism, such as when she writes that In the United States, southerners are, as a group, more friendly and polite than northerners, who are often more brusque and ruder. Or, that more intelligent people tend to have fewer children; perhaps intelligence is being diluted in the gene pool.

Should we really accept without any discussion that people who live in cities are more inventive, or that the number of friends we have is determined by our genes? Other assertions seem intended to knock us over with profundity but end up feeling like platitudes. While animals are driven by biological urges to find food and mate, humans are also motivated by meaning and purpose, Vince writes. Or, We are all creatures of time.

In the end, Vinces provocative assertion that we are becoming a new species and the implications for our future become somewhat vague. She writes that human cultural evolution involves peaks and troughs, and that while there are reasons for pessimism and despair about the fate of our species today, its mostly a problem of perspective. Once we recognise and embrace our shared humanity, according to Vince, we can achieve a good, liveable Anthropocene. Perhaps. The lack of specificity regarding how our species will transcend the serious problems she enumerates (tribalism, individual self-interest, partisanship, fascism, war, violence, environmental catastrophe) feels like a letdown after such an intellectually voracious book.

Its worth asking why there is such a public appetite for science books written from a God-like vantage point at this time. Why do we seek out authors who try to explain everything? Is there security in the sense that someone out there can offer a coherent narrative that makes sense of where we come from and where we are going? Unfortunately, such authoritative, sweeping narratives often leave out what makes science so interesting in the first place: not just the certainties but the unknowns. Transcendence never lets us in on the process or methodologies by which studies come to their conclusions. Readers arent given a sense of the evolution of ideas or debates within scientific disciplines, or the individual scientists behind these ideas and what might drive them to do their research. We are never shown that just as science gives us answers, it also exposes the mysteries of our existence.

M.R. OConnor, a 2016-17 Knight Science Journalism fellow at MIT, writes about the politics and ethics of science, technology and conservation. She is the author of Resurrection Science: Conservation, De-Extinction and the Precarious Future of Wild Things and Wayfinding: The Science and Mystery of How Humans Navigate the Earth.

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The Whirlwind Path of Human Evolution - The Wire

Healthcare Nanotechnology Market Evolution of Key Players That Will Change Industry: Amgen, Teva Pharmaceuticals, Abbott – Jewish Life News

Healthcare Nanotechnology Market Research Report provides customers with a complete analytical study that provides all the details of key players such as company profile, product portfolio, capacity, price, cost and revenue during the forecast period from 2020 to 2027. A Healthcare Nanotechnology market that includes Future Trends, Current Growth Factors, Meticulous Opinions, Facts, Historical Data and Statistically Supported And Industry-Validated Market Data.

This Healthcare Nanotechnology market research provides a clear explanation of how this market will make a growth impression during the mentioned period. This study report scanned specific data for specific characteristics such as Type, Size, Application and End User. There are basic segments included in the segmentation analysis that are the result of SWOT analysis and PESTEL analysis.

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Amgen, Teva Pharmaceuticals, Abbott, UCB, Roche, Celgene, Sanofi, Merck & Co, Biogen are some of the major organizations dominating the global market.

(*Note: Other Players Can be Added per Request)

Key players in the Healthcare Nanotechnology market were identified through a second survey, and market share was determined through a first and second survey. All measurement sharing, splitting and analysis were solved using a secondary source and a validated primary source. The Healthcare Nanotechnology market report starts with a basic overview of the Industry Life Cycle, Definitions, Classifications, Applications, and Industry Chain Structure. The combination of these two factors will help key players meet the market reach and help to understand offered characteristics and customer needs.

The report also makes some important suggestions for the new Healthcare Nanotechnology market project before evaluating its feasibility. Overall, this report covers Healthcare Nanotechnology market Sales, Price, Sales, Gross Profit, Historical Growth and Future Prospects. It provides facts related to mergers, acquisitions, partnerships and joint venture activities prevalent in the market.

This report includes market size estimates of value (million US $) and volume (K MT). The top-down and bottom-up approaches are used to estimate and validate the market size of the Healthcare Nanotechnology market, estimating the size of various other submarkets in the overall market. Major players in the market were identified through secondary studies, and market share was determined through primary and secondary studies. All ratio sharing, splitting and analysis were determined using the secondary source and the identified primary source.

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Complete knowledge of the Healthcare Nanotechnology market is based on the latest industry news, opportunities and trends in the expected region. The Healthcare Nanotechnology market research report provides clear insights into the influential factors expected to change the global market in the near future.

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Worldwide Market Reports is your one-stop repository of detailed and in-depth market research reports compiled by an extensive list of publishers from across the globe. We offer reports across virtually all domains and an exhaustive list of sub-domains under the sun. The in-depth market analysis by some of the most vastly experienced analysts provide our diverse range of clients from across all industries with vital decision making insights to plan and align their market strategies in line with current market trends.

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Healthcare Nanotechnology Market Evolution of Key Players That Will Change Industry: Amgen, Teva Pharmaceuticals, Abbott - Jewish Life News

Lost 8 Billion Light Years of Universe Evolution Revealed by Gravitational Waves – SciTechDaily

Artistic impression of the background hum of gravitational waves permeating the Universe. Credit: Carl Knox, OzGrav/Swinburne University of Technology

Every year, 2 million black hole mergers are missed Australian scientists work out how to detect them, revealing a lost 8 billion light-years of Universe evolution.

Last year, the Advanced LIGO-VIRGO gravitational-wave detector network recorded data from 35 merging black holes and neutron stars. A great result but what did they miss? According to Dr. Rory Smith from the ARC Centre of Excellence in Gravitational Wave Discovery at Monash University in Australia its likely there are another 2 million gravitational wave events from merging black holes, a pair of merging black holes every 200 seconds and a pair of merging neutron stars every 15 seconds that scientists are not picking up.

Dr. Smith and his colleagues, also at Monash University, have developed a method to detect the presence of these weak or background events that to date have gone unnoticed, without having to detect each one individually. The method which is currently being test driven by the LIGO community means that we may be able to look more than 8 billion light-years further than we are currently observing, Dr. Smith said.

This will give us a snapshot of what the early universe looked like while providing insights into the evolution of the universe.

The paper, recently published in the Royal Astronomical Society journal, details how researchers will measure the properties of a background of gravitational waves from the millions of unresolved black hole mergers.

Artistic impression of the background hum of gravitational waves permeating the Universe. Credit: Carl Knox, OzGrav/Swinburne University of Technology

Binary black hole mergers release huge amounts of energy in the form of gravitational waves and are now routinely being detected by the Advanced LIGO-Virgo detector network. According to co-author, Eric Thrane from OzGrav-Monash, these gravitational waves generated by individual binary mergers carry information about spacetime and nuclear matter in the most extreme environments in the Universe. Individual observations of gravitational waves trace the evolution of stars, star clusters, and galaxies, he said.

By piecing together information from many merger events, we can begin to understand the environments in which stars live and evolve, and what causes their eventual fate as black holes. The further away we see the gravitational waves from these mergers, the younger the Universe was when they formed. We can trace the evolution of stars and galaxies throughout cosmic time, back to when the Universe was a fraction of its current age.

The researchers measure population properties of binary black hole mergers, such as the distribution of black hole masses. The vast majority of compact binary mergers produce gravitational waves that are too weak to yield unambiguous detections so vast amounts of information is currently missed by our observatories.

Moreover, inferences made about the black hole population may be susceptible to a selection bias due to the fact that we only see a handful of the loudest, most nearby systems. Selection bias means we might only be getting a snapshot of black holes, rather than the full picture, Dr. Smith warned.

The analysis developed by Smith and Thrane is being tested using real world observations from the LIGO-VIRGO detectors with the program expected to be fully operational within a few years, according to Dr. Smith.

Reference: Inferring the population properties of binary black holes from unresolved gravitational waves by Rory J E Smith, Colm Talbot, Francisco Hernandez Vivanco and Eric Thrane, 10 June 2020, Royal Astronomical Society.DOI: 10.1093/mnras/staa1642

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Lost 8 Billion Light Years of Universe Evolution Revealed by Gravitational Waves - SciTechDaily

The First Gene on Earth May Have Been a Hybrid – Scientific American

DNA and RNA, the two major modern forms of genetic code underpinning all of earthly biology, could have coexisted in strict pairings on our planet before life arose here, scientists in England, Scotland and Poland say. Using a hydrogen cyanidebased chemical system intended to mimic conditions in Earths early history, the researchers made four bases, the molecular letters of the genetic alphabet. Strung together, these bases form gene sequences that cells translate into proteins. But surprisingly, the team found that of the four bases their experiments consistently made, two were in a form found in DNA, whereas the other two were of a kind seen in RNA.

The study, published in Nature and conducted by John Sutherland of the Medical Research Council Laboratory of Molecular Biology in Cambridge, England, and his colleagues, further undermines the so-called RNA world hypothesis. This idea, long one of the most prominent in origins-of-life research, posits that RNA formed the basis of Earths biosphere long before DNA and other molecules important to life emerged. Yet to date, scant evidence has been found of chemical pathways to make the RNA-exclusive system that rigid versions of the idea adopt or that could lead to DNA. People have tended to think of RNA as the parent of DNA, Sutherland says. This [paper] suggests that they are molecular siblings.

Other scientists who were not involved with the study question the plausibility of the conditions used in this hydrogen cyanide-based route, however. Frances Westall, director of the exobiology group at the French National Center for Scientific Researchs Center for Molecular Biophysics in Orlans, notes that forming the bases requires very specific conditions. Mixtures would need to dry out and be exposed to ultraviolet lighttwo hurdles most easily surmounted on dry land, which was in short supply during our planets ocean-covered early days more than four billion years ago. These conditions certainly existed on the early Earth, Westall says. They would not have been that common because there was not that much exposed landmass. Although she adds that the study is clever and not completely impossible, she concludes that there are other, better hypotheses as to locations for the emergence of life and prebiotic molecules.

Arguments about plausibility have plagued the chemistry-based quest to understand lifes beginnings on Earth since the early 1950s, when American researchers Stanley Miller and Harold Urey performed a landmark experiment. The pair simulated the effects of lightning in the early Earths atmosphere and ocean by triggering electrical discharges in flasks containing hydrogen, water, ammonia and methane. Although their experiment famously produced sizable organic molecules vital for biochemistry, for decades other researchers have debated the plausibility of its conditions. Nevertheless, Miller and Ureys work showed that it was relatively simple to make important substances, such as the amino acids that link up to form proteins that perform myriad functions within living cells. Of particular relevance to origins-of-life studies, proteins can act as catalysts, enhancing and speeding up other chemical reactions that would otherwise be too slow or inefficient to plausibly occur. But proteins are not the only possible catalysts behind the rise of life on Earth.

In work that would ultimately net the 1989 Nobel Prize in Chemistry, molecular biologist Sidney Altman and biochemist Thomas Cech found that RNAlong considered merely an intermediate carrier of genetic information that is subservient to DNAcan also behave as a catalyst. The RNA world hypothesis suggests that such molecules could self-replicate, enabling early evolution before the existence of DNA and proteins. The idea, however, was an overzealous, overenthusiastic response to a brilliant discovery, Sutherland says.

That response might have come partly because, to a naive chemist, it looks easy to leap from RNA to DNA. To create the long chains we often see coiled up into the DNAs iconic double helix, the bases are first connected to a backbone of sugar molecules. These combinations make up nucleosides: deoxyribonucleotides in DNA and ribonucleosides in RNAwhich, unlike its DNA cousin, forms a single helix. The nucleosides do not use table sugar, or sucrose, but rather ribose in RNA and deoxyribose in DNA (the different sugars give each material its first initial). The distinction between the two sugar types is tiny: just one oxygen and one hydrogen atom. Yet that difference is enough for DNA and RNA to have distinct biological roles. And biochemically removing the atoms is far harder than simply erasing the letters representing them in a notebook.

Another flaw in the RNA world idea has been the difficulty of making ribose in the conditions that probably existed on the early Earthand to then connect it to a base. Sutherland and his colleagues therefore sought more likely ways to make ribose sugars and ribonucleosides. One of their most promising approaches relied on two gases thought to have been relatively abundant in the planets early atmosphere: hydrogen sulfide and hydrogen cyanide. When dissolved in water, bathed in ultraviolet light and subjected to cycles of drying, these simple compounds have produced many more complex molecules. They include amino acids and glycerol, the backbones of fatty molecules that can form cells outer wall.

Sutherland took this approach a step further last year. Working with Ramanarayanan Krishnamurthys team at the Scripps Research Institute in La Jolla, Calif., he and his colleagues showed that the ribonucleosides cytidine and uridine could be transformed into deoxyribose and the nucleoside and deoxyadenosine. Nowprimarily via the efforts of team members Jianfeng Xu and Vclav Chmela, both then at the Laboratory of Molecular Biologythe researchers have made even more progress. They mixed some of the intermediate molecules from the teams previous studies with salts such as sodium nitrite and magnesium chloride that could have been prevalent on the primordial Earth, then subjected them to acidic conditions and heat, respectively. Through these steps, the scientists found two possible routes to add a fourth base, the less common nucleoside inosine, to their preexisting collection. The addition was enough to make a four-letter genetic alphabet in which each base in a strand would exclusively pair with one of the other three letters in a second strand That base-pairing complementarity is how modern RNA and DNA works. But in the experiment, two letters came from RNA, and two came from DNA.

The arrangement suggests that the chemistry to make RNA and DNA isnt as different as people have thought, Sutherland says. People have tended to think of RNA coming before DNA and somehow then being taken over. This, to me, is suggesting that its possible that you could have had an RNA-DNA hybrid, which could then give rise to the two separate molecules. Sutherlands team has not yet assembled the individual nucleosides and ribonucleosides into longer chains, however. Doing so is important, because showing that hybrid strands can really form and bind to a partner strand is crucial for moving the idea beyond speculation.

This is a key issue for Nicholas Hud, an origins-of-life researcher at the Georgia Institute of Technology, who was not involved in the study. He calls it an excellent compilation of organic chemistry research on water-based nucleoside synthesis. But Hud is not convinced that the paper resolves whether these nucleosides actually arose before living creatures. His own research suggests amino acids could have linked up to carry information and act as a catalyst before RNA. Hud thinks evolution would then have gradually produced the current genetic system over long stretches of geologic time. If a molecule looks very difficult, from a chemical perspective, to make, yet it functions exquisitely in biology, then its probably the case that it has been evolved over time, he says. For the same reasons, he is also skeptical about the RNA world hypothesis.

Furthermore, Hud sees the new studys reliance on rigid incremental steps, each performed in strict order and under carefully controlled conditions, as a significant weakness. If the order of the steps changed or certain products were not isolated, Sutherland and his colleagues would have made much less of the substances they are interested in, Hud says. That caveat reduces the chances of the scenario unfolding in the chaotic environs of the early Earth.

Sutherland admits that, absent a time machine to travel back to lifes true origins on our planet, plausibility is everything in this rarefied field of research. Even so, he firmly backs his teams work on establishing chemical routes to lifes building blocks. There are many, many fingers pointing at hydrogen cyanide, Sutherland asserts. Does it prove that it all happened from hydrogen cyanide? It doesnt prove it. But its good enough for me.

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The First Gene on Earth May Have Been a Hybrid - Scientific American

It’s Evolution Over Revolution for the All-New 2021 Ford F-150 – The Drive

Good Monday morning and welcome back to Speed Lines, The Drive's roundup of what matters in the world of cars and transportation. Today we're discussing the online car sales boom, what to expect from the debut of the all-new 2021 Ford F-150 this week, and the new date for Tesla's important Battery Day event.

Though plans have been waylaid by the pandemic, several important new cars are set to come out in 2020. But none of them are as important as the new 2021 Ford F-150. Sure, the new Bronco and Bronco Sport should be fun, and crucial additions to Ford's crossover lineup, but the F-150 is America's best-selling vehicleand the thing that keeps the lights on in Dearborn. It's the most crucial vehicle Ford makes, and we'll see it on Thursday.

Ford can't afford to screw this one up. Not after the debacle that was last year's Explorer launch, which was beset with delays and quality problems. Someone's head is going to be on a pike if there's anything close to problems like that again, especially when you consider that as strong a seller as the F-150 is, it's been losing ground to Ram and Chevrolet in recent years and this new one set to debut in a year when truck sales are basically propping up the American automakers.

So what can we expect from this all-important new F-150, this miracle machine that may or may not save CEO Jim Hackett's job? For starters, it's not going to be as revolutionary as its predecessor, which controversially switched to an aluminum body. No, instead, the focus will be on the interior and technology, reports Automotive News.

By now you've probably seen the big touch screens or read about the flat-folding seats you can sleep in. There's also the next-generation Sync system that now allows for over-the-air software updates, a hybrid system that can serve as a mobile generator, and maybe a few unexpected surprises. A fully electric version of the truck is also set to bow at some point, but I don't think we'll see that variant on Thursday.

Tune in to The Drive this week for more info as it's released, or as is more likely with Ford, as it leaks out.

It took a global pandemic to drag America's car dealerships kicking and screaming onto the internet. But in recent months, despite excruciatingly slow sales amid the economic downturn, a robust online presence has been the saving grace for many dealers. Home delivery, online financing, virtual tours and an emphasis on completing the process on the internet have all equated to a big shift for dealers. Until recently, research was the primary thing done online; now more of the process can be completed that way too.

The Wall Street Journal reports that those changes are here to stay, especially as we come to understand we'll be dealing with COVID-19 for a long time. One Chevrolet dealership interviewed even saw sales up 20 percent year over year in May, despite the downturn, because of the speed with which cars can be bought online now.

But there's a chance that long-term, this will mean fewer dealership jobs:

After some sales success, many in the industry expect the online push to continue. As dealerships reopen across the country, many are rethinking how they staff locations, including cutting traditional sales roles and shifting more employees into digital operations, managers and owners say.

[...] AutoNation, which laid off 7,000 workers this spring as the outbreak spread, anticipates it will need fewer sales staff going forward. While it plans to bring back some workers, many showroom positions will go unfilled as it redirects more employees to online retailing, a company spokesman said.

Further proof that many jobs are sadly not coming back when the pandemic is "over."

Finally, speaking of important debuts this year, Tesla has punted its July 7 Battery Day event to September 15, tentatively. It was postponed along with Tesla's shareholder meeting due to coronavirus concerns; CEO Elon Musk made the announcement on Twitter.

This event is said to be a big deal, and "one of the most of exciting days in Tesla's history", as Musk put it recently. It was where Tesla was expected to unveil the so-called "million-mile batteries" it's been working on, a new kind of low-cost, low-cobalt, long-lasting EV battery that could achieve cost parity with internal combustion vehicles. If true, it's going to be a game-changer for Tesla and the EV sector as a whole.

We'll have to wait a bit longer to see what's up Musk's sleeve. Hopefully, it won't go the way battery swapping did.

GM takes 3D printing beyond prototypes (Automotive News)

Aston Martin taps ex-Jaguar Land Rover CFO Kenneth Gregor as finance head (Reuters)

Spains Auto Industry to Get $4.2 Billion in Government Stimulus (Bloomberg)

New Woe for a Jittery N.Y.C.: Illegal Fireworks Going Off All Night (NY Times)

The strategies to help you build a lower-risk Covid social bubble (Quartz)

Ill Be Gone in the Dark Is a Touching Eulogy for Michelle McNamara, the Writer Obsessed With Finding the Golden State Killer (MEL Magazine)

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It's Evolution Over Revolution for the All-New 2021 Ford F-150 - The Drive

11 of the Most Important Milestones in the Evolution of Diving Suits – Interesting Engineering

Diving suits have enabled us to explore the deepest ocean depths. Initially developed to reclaim lost items from sunken ships or inspect ship's hulls, they have since opened up new possibilities for ocean exploration.

RELATED: THE WORLD'S OLDEST KNOWN DIVING SUIT, THE OLD GENTLEMAN

And so, without further ado, here are some of the major milestones in the evolution of the diving suit. This list is far from exhaustive and is in no particular order.

One of the first major steps in the evolution of the diving suit was Konrad Kyeser's "Diving Dress". A renowned military engineer, Kyeser wrote a book in the early-1400s called Bellifortis, on military arts and technology.

Within it was a description and depiction of an early diving suit.

Another important step in the development of the modern diving suit was Franz Kessler's diving bell. Kessler spent his life as an artist and inventor within the Holy Roman Empire between the 16th and 17th centuries.

One of his inventions, the diving bell, was a crude but effective underwater exploration device. Kessler is believed to have been inspired by the earlier work ofGuglielmo de Lorena, who actually dove in a sunken Roman vessel in his own diving bell in the 1530s.

Kessler's devive consisted of an airtight, wooden, upside-down, bell-chamber that could accommodate a small crew of divers. Once lowered into the water, air would remain trapped inside the bell, allowing the crew to breathe underwater for a short period of time.

In the 15th century, Leonardo Da Vinci made the first known mention of the concept of air tanks. In one of his notebooks, called the Atlantic Codex, he provided tantalizing descriptions of systems that may have been used at the time to artificially breathe air underwater.

He also made some sketches of what appeared to be different kinds of snorkels and an air tank that was carried on the diver's chest. No mention is made of whether these tanks were connected to the surface or not.

Additional drawings showed a form of a complete diving suit, equipped with some sort of mask, with a box containing air. He even included provisions for a urine collector in his design.

Da Vinci also famously made designs for an "Underwater Army" diving suit with bamboo pipes, sheepskin suit, and a bell-shaped air-trap.

In the early-1700s, an English inventor called John Lethbridge developed one of the first-known, completely enclosed suits to help divers during salvage work on sunken ships. His suit provided the diver with a fair amount of maneuverability in order to complete the work successfully.

After initial trials in his garden pond, Lethbridge actually used the device to dive a number of wrecks -- four sunken English men-of-war, one East Indiaman, a Spanish galleon, and some galleys.

Through his exploits as a salvage diver, Lethbridge became very wealthy, with one particular dive on the Dutch Slot ter Hooge, sunk off Madeira, netted him three tons of silver.

In the 1710s, the French aristocratPierre Rmy de Beauvemade another important step forward in the development of the diving suit. His 'diving dress' featured a metal helmet with two connected hoses.

One hose supplied the helmet with air from above via a bellows, the other removed the diver's exhaled air.

Another major milestone in the development of the modern diving suit was Charles and John Deane's diving helmet. Building on their work for an earlier smoke helmet for the fire brigade in the 1820s, the brothers adopted the design for potential use underwater.

At the time, diving bells were the main go-to for dive and rescue missions, but were very limited. The Deane's design was effectively a large metal bowl with vision ports that also sported a short jacket that could prevent water from reaching the wearer's face.

Air was supplied to the helmet via a surface air pump. It also included an air exhaust that would direct bubbles away from the diver's field of vision.

Yet another important step in the evolution of the diving suit was the work of Lodner D. Phillips. In the 1860s, Phillips developed one of the world's first-ever, fully-enclosed atmospheric diving suits.

It featured articulated joints, a viewing chamber, and even a hand-cranked propeller for movement. While there is documentary evidence of the suit's existence, it is not clear if one was ever made for use.

In the 1880s, however, the Carmagnolle Brothers, drawing their inspiration from Phillip's design, developed their own articulated atmospheric diving suit.

Another important development in the evolution of the diving suit was "The Old Gentleman of Raahe". Created to help inspect the hulls of ships without the need for a drydock, it is currently one of the oldest surviving early diving suits in the world.

Dating to the early 18th century, this suit is primarily constructed using hand-stitched seams. The suit was sealed and waterproofed using a mixture of mutton tallow, tar, and pitch.

The helmet was reinforced with a wooden frame, to prevent it from collapsing, and an air pipe was affixed to the front. Air was supplied using bellows, and exhaust air was removed via a pipe at the rear of the helmet.

Skipping forward in time, another milestone in the evolution of the diving suit was the JIM suit. Developed in the late-1960s by Mike Humphrey and Mike Burrow, the first JIM suit was inspired by Joseph Peress' 1930s Tritonia diving suit.

An atmospheric diving suit, it was specifically designed to maintain an internal pressure of 1 atmospheredespite external water pressure. Because of this, no gas mixtures were required, and deep-sea divers did not need to undergo decompression when they returned to the surface.

It was made from cast magnesium and weighed in at around 499 kg. The suit featured breathing apparatus that supplied air for up to 72 hoursand delivered air through the mask directly to the diver's mouth and nose.

No discussion of diving equipment would be complete without a discussion of self-contained underwater breathing apparatus (SCUBA). While many of the basic elements of SCUBA had been invented by the 1940s (notably Henry Fluess' rebreather), it tookJacques-Yves Cousteau andEmile Gagnan to modify them sufficiently to make SCUBA of practical use for most people.

The pair were able to redesign a car regulator to function as a demand valve that provided divers with a supply of compressed air delivered with each breath. This compressed air was stored in a tank, allowing the diver, for the first time, to swim untethered for long periods of time.

Called the "Aqua-Lung" by Cousteau and Gagnan, the lightweight and relatively easy-to-use SCUBA equipment suddenly opened up diving for pleasure to the general public.

And finally, the "Newtsuit" is the current go-to diving suit for sea exploration and underwater work. It was invented by Phul Nuyetten in the late-1980s and is a fully articulated atmospheric diving suit that enables divers to reach a depth of up to 305 meters.

The suite features an acrylic dome for visibility and can be modified with an optional backpack, with two horizontal and two vertical thrusters for added maneuverability underwater.

Primarily used for ocean drilling rigs, pipelines, salvage work, and photographic studies, it is the standard deep-sea diving suit of many of the world's navies too.

Unlike the JIM suit, the Newtsuit is primarily composed of aluminum, trimming its total weight down to113 kgs, making it more practical and easier to use than its heavierpredecessor.

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11 of the Most Important Milestones in the Evolution of Diving Suits - Interesting Engineering

Molecular Templates’ Presentations at the American Association of Cancer Research (AACR) Annual Meeting 2020 Highlight Evolution of ETB Platform -…

Update Provided Phase I Study of MT-5111 in HER2-positive Cancers

Conference Call and Webcast to Discuss AACR Posters on June 25th at 10:30am Eastern Time

AUSTIN, Texas, June 22, 2020 (GLOBE NEWSWIRE) -- Molecular Templates, Inc. (Nasdaq: MTEM, Molecular Templates, MTEM or the Company), a clinical-stage biopharmaceutical company focused on the discovery and development of the Companys proprietary targeted biologic therapeutics, engineered toxin bodies (ETBs), announced that four poster presentations featuring pre-clinical data on its pipeline programs are being presented at the American Association of Cancer Research (AACR) Virtual Annual Meeting 2020, being held June 22-24, 2020. Copies of the posters presented at AACR can be found in the Presentations section of Molecular Templates website at http://ir.mtem.com/events-and-presentations/presentations. MTEM also announced an update on its ongoing Phase I study of MT-5111 in HER2-positive cancers.

Poster Title: In Vivo Efficacy of a PD-L1 Targeted, Antigen Seeding Engineered Toxin Body

MT-6402 is a unique agent designed to deplete tumor and repressive immune cells in the tumor microenvironment. It has multiple unique mechanisms of action that may provide greater potency than is seen with current PD-L1 antibodies. MT-6402 was shown to have potent in vitro activity against a variety of PD-L1+ tumor cells and results in tumor growth delay and survival benefits in NSCLC PDX in vivo model. MT-6402 can alter the immunophenotype of the tumor and allow for recognition by effector T cells. Non-human primate (NHP) data show that MT-6402 mediated PD-L1+ immune cell clearance can elicit highly potent monotherapy immune activation in a way that has not been seen previously in NHP models with checkpoint inhibitors. MT-6402 is slated for IND filing in 2H20.

Poster Title: CTLA-4 Targeted Engineered Toxin Bodies Designed to Deplete Regulatory T Cells (Tregs)

Tumor resident regulatory T cells (Tregs) are important mediators of an immunosuppressive tumor microenvironment (TME) promoting tumor immune evasion. The presence of Tregs, and a higher ratio of Tregs to effector T cells in the TME, are associated with poor prognosis. There is concern that antibodies to CTLA-4 are not sufficiently effective at clearing Tregs from the TME. ETBs are being developed to specifically target CTLA-4+ Tregs and clear them from the TME. Because CTLA-4-targeted ETBs preferentially affect Tregs versus CTLA-4+ CD8 T-cells, ETBs may also have a safer profile than CTLA-4 antibodies. In co-culture models CTLA-4 ETBs were shown to relieve Treg suppression of T-effector proliferation. Experiments in mice showed that CTLA-4 ETB 1 (as labeled on the AACR poster) displays a short serum half-life and is well tolerated in vivo. An IND for a CTLA-4 ETB is expected to be filed in 2021.

Poster Title: Novel Engineered Toxin Bodies Targeting SLAMF7 (CS1)

SLAMF7 (CS1) is a clinically validated target of monoclonal antibody therapy for the treatment of multiple myeloma. The approved antibody-based therapeutic, elotuzumab, works indirectly by recruiting effector cells to the tumor but does not show single agent clinical activity. ETBs have the potential to deplete malignant cells by means of potent and direct cell kill through enzymatic ribosomal destruction. SLAMF7 ETBs were shown to be active alone and in the presence of elotuzumab. Epitopes distinct from elotuzumab are options for ETB engagement, allowing activity in the presence of elotuzumab. SLAMF7 ETBs combine with standard of care chemotherapy (IMiDs) and bortezomib in a positive manner in vitro. Lead selection is underway with the testing of various ETB scaffolds and additional binding domains targeting multiple SLAMF7 epitopes.

Poster Title: CD45 Targeted Engineered Toxin Bodies Deplete Hematopoietic and Malignant Cells

CD45, the leucocyte common antigen, is a haemopoietic cell-specific tyrosine phosphatase. Targeted and potent ETBs with intrinsically short half-lives are being developed to specifically destroy CD45 expressing cells including malignant cells of B, T and myeloid lineage. A single agent, targeted conditioning method for bone marrow transplant (BMT), employing ETBs, has the potential to increase patient safety and eliminate genotoxic effects that are associated with existing conditioning regimens. Antibody discovery campaigns have the potential to direct ETBs to specific isoforms of CD45 for refinement of indications including various cancers and autoimmune diseases.

Update on Phase I study of MT-5111

MT-5111, a HER2 targeted ETB, is in an ongoing Phase 1 study that has two parts: Part 1 is dose escalation and Part 2 is dose expansion, which will begin when a maximum tolerated dose (MTD) or Recommended Phase 2 Dose (RP2D) is established in Part 1. To date, 10 subjects, with a median of 5 prior lines of therapy and a median of 2 prior HER2-targeting regimens, have been treated with MT-5111 (metastatic cholangiocarcinoma n=5, metastatic breast cancer n=4, metastatic gastro-esophageal junction carcinoma n=1). Thus far, no dose limiting toxicities (DLTs) have been observed in any cohort and MT-5111 appears to be well tolerated, with no cardiotoxicity to date (cardiotoxicity is a known potential toxicity for HER2 targeted therapies).

Currently there are 4 subjects in total on treatment from the second (1 g/kg/dose) and third cohorts (2 g/kg/dose). No cardiac AEs or abnormalities in cardiac biomarkers have been noted thus far. Reported AEs that may be causally related among the 3 cohorts to date include the following: one instance of grade 1 chills, one instance of grade 1 hypophosphatemia, one instance of grade 1 nausea, and one instance of grade 2 AST elevation. The grade 2 AST elevation occurred in a subject in cohort 1 with disease progression in hepatic metastases; no causally related AST or ALT elevations have been noted in any other subjects to date. The ongoing subject from cohort 2 (45 y/o female with metastatic breast cancer) has stable disease (the subject only has evaluable disease but no measurable lesions per RECIST 1.1, and is classified as non-CR, non-PD per protocol) and remains on treatment, now in cycle 5. One subject in cohort 3 with metastatic breast cancer has had a follow-up CT scan at the end of cycle 2 and has stable disease. Six subjects have discontinued for disease progression and two subjects are too early to evaluate. Cohort 4 (3.0 g/kg/dose) is anticipated to open shortly. Molecular Templates is encouraged by the safety profile to date in these heavily pretreated patients and expects to provide an update on results from the patients currently on treatment as well as higher dose cohorts from the dose escalation portion of the Phase 1 study (including doses that are predicted to be clinically active based on preclinical data) in 4Q20.

Conference Call and Webcast to Discuss AACR Posters

Molecular Templates will host a live webcast and conference call in Eric Poma, Ph.D., Molecular Templates Chief Executive Officer and Scientific Officer, will provide an update on the Companys pipeline programs and discuss the four abstracts presented at AACR.

Thursday, June 25th at 10:30am Eastern Time

Domestic: 877-705-6003International: 201-493-6725Conference ID: 13704222Webcast: https://viavid.webcasts.com/starthere.jsp?ei=1322770&tp_key=655ccca2f4

The Molecular Templates management team will be available for a question and answer session at the conclusion of this call.

About Molecular Templates Molecular Templates is a clinical-stage company focused on the discovery and development of targeted biologic therapeutics. Our proprietary drug platform technology, known as engineered toxin bodies, or ETBs, leverages the resident biology of a genetically engineered form of Shiga-like Toxin A subunit to create novel therapies with potent and differentiated mechanisms of action for cancer and other serious diseases.

Forward-Looking StatementsThis press release contains forward-looking statements for purposes of the Private Securities Litigation Reform Act of 1995 (the Act). Molecular Templates disclaims any intent or obligation to update these forward-looking statements, and claims the protection of the Acts Safe Harbor for forward-looking statements. All statements, other than statements of historical facts, included in this press release regarding strategy, future operations, future financial position, future revenue, projected expenses, prospects, plans and objectives of management are forward-looking statements. In addition, when or if used in this press release, the words may, could, should, anticipate, believe, estimate, expect, intend, plan, predict and similar expressions and their variants, as they relate to Molecular Templates may identify forward-looking statements. Examples of such statements include, but are not limited to, statements relating to the Companys options with respect to the second and third tranche term loans.

Forward-looking statements are not guarantees of future performance and involve risks and uncertainties. Actual events or results may differ materially from those discussed in the forward-looking statements as a result of various factors including, but not limited to, the uncertainties inherent in the preclinical and clinical development process; whether the Company will achieve its expected milestones; risks from global pandemics including COVID-19; whether the Companys cash resources will be sufficient to fund its continuing operations for the periods and/or trials anticipated; the ability of the Company to protect its intellectual property rights; and legislative, regulatory, political and economic developments, as well as those risks identified under the heading Risk Factors in the Companys filings with the SEC. Any forward-looking statements contained in this press release speak only as of the date hereof, and the Company specifically disclaims any obligation to update any forward-looking statement, whether because of new information, future events or otherwise

Investor Contact:Adam CutlerChief Financial Officeradam.cutler@mtem.com862-204-4006

Source: Molecular Templates, Inc.

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Evolution of the immune system and modern lifestyle have left us vulnerable to coronavirus – iNews

As we shelter behind closed doors, the Sars-CoV-2 virus causing Covid-19 has spread like no other disease before. In just a few months, from its identification in December 2019, more than a third of humanity was living under some form of lockdown. It is, to use the clich of 2020, unprecedented.

The Covid-19 pandemic has undeniably and dramatically exposed many weaknesses in human society. But it has also revealed that, despite the enormous advances we have made in medical science and technology, humans are just as vulnerable as any other organism to a novel disease. We are equipped with a very effective immune system that keeps us all alive, but that system has to learn to identify new invaders, and to react appropriately. Our naive immune system renders us all vulnerable to Covid-19, and in some people the overreaction of the immune system in response to the virus, a cytokine storm, can be fatal.

Our immune system, in all its complexity, is an evolved feature. It is an adaptation that, through natural selection, has been shaped and refined to combat disease. But there are subtler aspects of our evolutionary heritage at play during this pandemic. In the modern world of our own creation some of these aspects, so central to our global dominance as a species, can also conspire against us.

Evolution has equipped humans with large and complex brains capable of abstract thought, innovation, language and qualities we term intelligence. The evolved structure of our brain and the thought processes it allows also help us to be social, living and working collectively. Together, these features have allowed humans to achieve truly incredible things. At the same time, some of these features have rendered us horribly and uniquely vulnerable topandemics.

Social behaviour was essential during our evolutionary past, when our ancestors were far more likely to be the hunted than the hunter. Grouping for defence, and using the power of groups to keep safe and extend our diet, went hand-in-hand with evolutionary changes, and larger social units became possible. This accelerated greatly when we latched onto the idea of agriculture. Released to some extent from a foraging existence, human societies expanded, our skulls, dentition and metabolism evolved, technological advances flowed and ever larger settlements became possible. The supercity of the modern world is the culmination of this simultaneous expansion and concentration of humanity. Technology, arising from our unparalleled ability for innovation allows for such control over our environment that sometimes tens of millions of people are able to live a high-rise, high-density lifestyle, literally on top of each other. But high-density urban living provides the perfect conditions for a disease to spread.

The modern lifestyle hugely increases the number of people we have contact with, both socially and when we are crammed together in offices, streets and train carriages. Our social behaviour is now a threat, our conversations a liability. The primary defensive strategy in the face of Covid-19 is to actively and continually oppose our evolutionary heritage and, rather than group together for defence, we must defend ourselves by isolation.

Social distancing is affecting most parts of our daily lives at a local level, but we have also distanced globally. Our large and innovative brains dreamed of flight long before we invented the jet engine and shrank the world. The problem is that our ability to fly is also shared by any diseases we carry with us.

Gathering together people from far and wide for long periods in cramped airports and flying them all over the world is a wonderful dispersal mechanism for a virus like Sars-Cov-2. It is evolution that gave us all the innovative power of our brain, and it is our brain that has allowed us to create a globalised, interconnected world. If viruses had hands they would be have been rubbing them together in anticipatory glee when the Wright brothers took to the air.

Our cerebral evolutionary legacy laid the track for this pandemic but evolved aspects of our bodies arent always helping either. We have a wonderful ability to lay down fatty reserves, and for many of us the modern world is a landscape of caloric potency and opportunity.

Obesity is a major health risk any way you look at it, but it is also emerging as a risk factor for complications arising from Covid-19. The simple evolutionary story of obesity, often repeated, is that we are famine-adapted creatures living in a world of feast. The thrifty gene hypothesis as it is known is a seductive and popular idea, not least because of the implication that getting fat is somehow not our fault.

But it has proved difficult to support. Thrifty genes have been identified, in South Pacific islanders for example, but globally the evidence suggests that obesity cannot be put down to a Boy Scout metabolism, always prepared for famine.

Another evolutionary explanation is that, a few million years ago, the predation risk to our ancestors decreased. Evolved upper limits to fat storage were no longer so restrained by having to run away and they changed upwards not by natural selection but by a process called genetic drift (the drifty gene hypothesis). Whether we are thrifty or drifty, echoes of the mismatch between our evolutionary past and the calorie-filled modern world we have created are being heard.

Beneath our thin veneer of civilisation, far away from the dazzle and glare of our achievements, humans are vulnerable animals. Covid-19 has changed that. It has found itself the perfect host, a species with a powerful evolutionary double-hit of highly social behaviour and an innovative brain, leading to dense urban living and global travel.

The very nature of the modern world, building as it does on our evolutionary heritage, is our weakness in this pandemic. But just as our brain power helped us to get into this, it will also be our way out.

Unfit for Purpose: When Human Evolution Collides with the Modern World by Adam Hart (Bloomsbury Sigma, 16.99) is out now

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Evolution of the immune system and modern lifestyle have left us vulnerable to coronavirus - iNews

Headache May Predict Clinical Evolution of COVID-19 – Medscape

Editor's note: Find the latest COVID-19 news and guidance in Medscape's Coronavirus Resource Center.

Headache may be a key symptom of COVID-19 that predicts the disease's clinical evolution in individual patients, new research suggests.

An observational study of more than 100 patients showed that headache onset could occur during the presymptomatic or symptomatic phase of COVID-19 and could resemble tension-type or migraine headache.

Headache itself was associated with a shorter symptomatic period, while headache and anosmia (loss of sense of smell) were associated with a shorter hospitalization period.

In a subgroup of participants, headache persisted even after the symptoms of COVID-19 had been resolved.

Investigators note that understanding the pathophysiology of headache in COVID-19 could improve understanding of migraine and other headache disorders.

"It seems that those patients who start early on, during the asymptomatic or early symptomatic period of COVID-19, with headache have a more localized inflammatory response that may reflect the ability of the body to better control and respond to the infection by SARS-CoV2," lead investigator Patricia Pozo-Rosich, MD, PhD, head of the Headache and Craniofacial Pain Unit at Vall d'Hebron University Hospital, Barcelona, Spain, told Medscape Medical News.

She presented the findings at the American Headache Society (AHS) Annual Meeting 2020, which was virtual this year because of the COVID-19 pandemic.

Headache is one of the main symptoms of COVID-19. A recent study of 214 patients with COVID-19 showed that approximately 13% of the participants had headache and 5% had anosmia.

SARS-CoV2 penetrates the cells through the ACE2 receptor, which is present throughout the body.

"SARS-CoV2 enters the body through the nasal cavity and it probably penetrates the nervous system in the periphery through afferent branches of the olfactory and trigeminal nerve," Pozo-Rosich said.

It travels to the lungs and, later, the bloodstream. This generates systemic inflammation that may turn into a cytokine storm. Evidence has identified cortical hyperintensities and olfactory bulb hyperintensities in patients with COVID-19, suggesting that the virus directly infects the central nervous system.

Interleukin-6 (IL-6), one of the main inflammatory molecules, has been proven to be related to COVID-19 and has become a therapeutic target. Levels of IL-6 may be lower and tend to be more stable in patients with both COVID-19 and headache than in patients with COVID-19 only.

The researchers observed 130 patients (51% women; mean age, 54 years) with COVID-19 who were attended by neurologists at Vall d'Hebron. In this group, 74.4% had headache.

Patients with headache tended to be younger than those without headache (mean age, 50 years vs 63 years, respectively) and tended to be women (58.6% vs 29.4%).

Approximately one third of patients with headache had a history of migraine. Most reported mild to moderate pain that resembled tension-type headache. In participants with severe pain and migraine-like features, headache more often began during the asymptomatic phase of COVID-19.

The investigators followed up on 100 of the 130 patients with COVID-19, of whom 74 had headache. About 38% of these patients had ongoing headache after 6 weeks, which suggests that some patients may develop a new daily persistent headache once a 3-month period has elapsed.

Half of this group had no previous headache history. Headache had been the prodromal symptom of COVID-19 for 21.4% of these patients.

Results showed that headache predicted the clinical evolution of COVID-19. The symptomatic phase of COVID-19 was 7 days shorter for patients with headache than for those without headache.

In addition, the period of hospitalization was 7 days shorter for patients with headache and anosmia compared with patients who had neither headache nor anosmia.

Most therapies, including ibuprofen, candesartan, and anti-CGRP monoclonal antibodies, are safe for treating headache in COVID-19, the investigators note.

"We should just try to initially avoid steroids to avoid interference with the body's reaction to SARS-CoV2," Pozo-Rosich said.

Researchers at Thomas Jefferson University in Philadelphia are currently studying intranasal vazegepant, an anti-CGRP therapy, as a way to potentially blunt the severe inflammatory responsein the lungs of patients with COVID-19, she noted, adding that this peptide may have a future role not only in headache, but also in COVID-19.

Commenting on the study for Medscape Medical News, Matthew S. Robbins, MD, associate professor of neurology at Weill Cornell Medicine, New York City, said the findings associating headache with a shorter symptomatic phase of COVID-19 were "interesting."

"Headache is common with mild viral infections. More severe viral infections may simply feature more overwhelming respiratory symptoms and fever that lead to underreporting or underascertainment of headache," said Robbins, who was not involved with the research.

He noted that the finding showing an association of headache and COVID-19 with a younger age and in women "may be related to a higher prevalence of migraine biology in such patients, and being triggered by the virus or the psychological stress associated with it."

Robbins added that viral illnesses have long been associated with new daily persistent headache, "dating back to the early 1980s," when it was first described in association with Epstein-Barr virus. These infections have also been implicated in the progression of migraine to chronic migraine in adolescents.

"In my view, treatment should be aimed at the symptomatic headache type for which new daily persistent headache resembles, regardless of the potential inciting factor," Robbins said.

Pozo-Rosich has received consulting fees from Allergan, Amgen, Almirall, Biohaven, Chiesi, Eli Lilly, Medscape, Novartis, and Teva Pharmaceuticals. Robbins has disclosed no relevant financial relationships.

American Headache Society (AHS) Annual Meeting 2020: Presented June 13, 2020.

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Headache May Predict Clinical Evolution of COVID-19 - Medscape

Happy Fathers Day to All the Fish Dads Underwater – The New York Times

A clown fish uses his fins to fan water across a glistening mass of eggs, keeping them aerated. A silver arowana scoops up his fertilized eggs with his mouth and holds them gently for two months, until a host of miniature adults swims free from his jaws. A seahorse drifts through coral, his belly pouch swollen with unborn young.

Most fish are uninvolved parents. They dump their eggs and sperm, then swim off and let nature take its course. But some species of fish take their parental duties more seriously and among them, the majority of caring parents are dads. Care from mothers, or from both parents at once, is much less common. In a study published last fall in Evolution, researchers found evidence that paternal care, the system in which dads are the sole caretakers, has evolved dozens of times in fish.

These fish arent exactly helicopter dads. Their most common parenting style is simply guarding eggs after theyre fertilized. Some people are surprised this is considered care, said Frieda Benun Sutton, an evolutionary biologist at the City University of New York.

But it does count. To learn more about why this type of care in fish usually comes from dads, Dr. Benun Sutton and her co-author, Anthony Wilson, of Brooklyn College, took a deep dive into the family history of fish parents. They started with an evolutionary tree, built by other researchers in 2017 using genetic data, that shows how almost 2,000 fish species are related. Then they mapped onto the tree all the information they could find about parental care in those species: Were young cared for by fathers, mothers, both or nobody? They also added other factors including the size and number of each fishs eggs and how theyre fertilized.

The completed tree showed that care by fathers is no evolutionary accident: It has arisen at least 30 separate times. Hundreds of the species in this sample have absent mothers and caring fathers. But why?

We do see consistent patterns that occur across the entire evolutionary tree, Dr. Benun Sutton said.

One important pattern is that every species with paternal care also uses external fertilization sperm and egg meeting out in the open and spawns in pairs, not groups. This makes sense, the authors say, because when fertilization happens in a group or inside a females body, a male cant be sure of his paternity. Caring for those young could be a waste of his energy, evolutionarily speaking. But if he fertilizes a fresh batch of eggs and then stands guard over them, he believes hes caring for fish that share his genes.

The link between external fertilization and doting dads is a hypothesis several decades old. But more recent research has shown that external fertilization doesnt ensure fish dads end up caring for their own young, said Sigal Balshine, a behavioral ecologist at McMaster University in Ontario. Other males may sneak some of their own sperm onto the eggs.

In a 2012 study of plainfin midshipman fish, Dr. Balshine and her co-authors gave paternity tests to babies and found that only about half of the young in a nest belonged to the dad who was guarding it. There was a lot more hanky-panky going on, Dr. Balshine said.

The new study is the most comprehensive look yet at how parenting has evolved in fish, Dr. Balshine said. But it looked at only a small fraction of the worlds more than 30,000 fish species, and may not be a representative sample.

Dr. Benun Sutton agrees that the link between paternal care and external fertilization is an older, perhaps dusty hypothesis that her work revives. But if caring fish fathers were being cuckolded too often, she says, they would pass on their genes so sparsely that their behavior would die out altogether.

The puzzle of fish dads has long fascinated biologists, Dr. Balshine said.

When we humans think about parental care, we think immediately of moms holding newborn babies, she said. Its true that females are the primary caregivers across much of the animal kingdom, from mammals to birds to reptiles. Fish provide an intriguing counterexample.

Dr. Benun Sutton said fish illustrate that, under the right circumstances, either parents care can be critical. Theres no evolutionary rule that moms have to be the main providers a lesson we can apply to our own species, she said. There is a very important role for dads.

Excerpt from:

Happy Fathers Day to All the Fish Dads Underwater - The New York Times

RURAL AID AND EVOLUTION MINING BRINGING THE JOY OF MUSIC TO GAYNDAH SCHOOLS – PRWire

Sounds of music and excited children will ring out from Gayndah schools this week

WHAT: RURAL AID AND EVOLUTION MINING BRINGINGTHE JOY OF MUSIC TO GAYNDAH SCHOOLS

WHERE:Saint Josephs Catholic Primary School(10.30am) 38 Meson Street, Gayndah QLD 4625

WHERE:Burnett State College (1pm) 65 PineappleStreet, Gayndah QLD 4625

DATE: Tuesday. 23 June 2020

TIME:Saint Josephs Catholic Primary School 10.30am and Burnett State College - 1pm

CONTACT:Rural Aid Media 0447 116 757 | media@ruralaid.org.au

SPOKESPERSON: Rural Aid CEO John Warlters | 0409 618 641

ON-SITE CONTACT: Jen Curnow-Trotter Rural Aid CommunitySupport 0416 765 678

Rural Aid is delighted to announce theCommunity Support team is delivering musical instruments to Burnett State Collegeand St Josephs Catholic Primary School in Gayndah, tomorrow.

Rural Aid CEO John Warlters said Burnett State College and St Joseph's Catholic Primary School are part of a generous $120,000 donation of musical instruments from Evolution Mining to eight schools around their Mt Rowden and Cracow mining operations.

"I would like to thank Evolution Mining for their generous donation, which is part of a $1.5 million donation to help support Aussie farmers with disaster assistance and their communities," John Warlters said.

In the past, weve been well knownfor our disaster assistance program: providing hay, drinking water, financialand counselling assistance to farmers, rural and regional communities. Buildingsustainable, stronger futures for primary producers and rural communitiesunderpins everything we do.

Were pleased to announce a new remitfor community focused support, including schools. All community initiatives,from July 2020, will fall under the auspice of Rural Aids Stronger FuturesProgram.

Schools are a key element of allrural communities and we will continue supporting them as part of our focus oncommunity sustainability. This was evidenced recently with our technology forschools initiative to assist rural schools with at-home-learning.

Weve had some challenges thrown ourway with Covid-19 in having to place Rural Aids Our Town and Farm RescuePrograms in hibernation. And, our volunteers are readying themselves for therecommencement of community support activities.

Im please to say weve been workingin the background to deliver fodder and drinking water during Covid-19 andplanning for when schools return and, our workforce can make their way safelyback out in the field.

Were helping schools prepare for thecommencement of Term 3 music programs with deliveries underway this week.

Our thanks go to Rural Aid sponsor,Evolution Mining, a large employer of local communities backing localcommunities. They have made this and many other opportunities possible for farmersand rural and regional communities," John Warlters said.

Other schools also receiving musical instruments in the Gayndah region, thanks to Evolution Mining's generosity, are listed below.

Some of the schools receiving musical instruments:

Date

Time

School

Tuesday 23 June 2020

8.30am

Coalstoun Lakes State School

Tuesday 23 June 2020

10.30am

St Josephs Catholic Primary School

Tuesday 23 June 2020

1.00pm

Burnett State College

Tuesday 23 June 2020

2.00pm

Gayndah State School

Wednesday 24 June 2020

10.00am

Eidsvold State School

Wednesday 24 June 2020

11.15am

Mundubbera State School

Wednesday 24 June 2020

12.15pm

Boynewood State School

About RuralAid

RuralAid is one of Australias largest rural charities. Well known for the highlysuccessful Buy a Bale campaign, the charity also provides financialassistance, water and counselling to farmers in times of drought, flood orfire. Other initiatives support its vision that farming and rural communitiesare safeguarded to ensure their sustainability both during and after thesenatural disasters. Visit http://www.ruralaid.org.au for further information onthese programs and other support for our rural communities.

Media: 0447 116757 | media@ruralaid.org.au

Spokesperson: Rural AidCEO John Warlters | 0409 618 641

FollowRural Aid for updates on:

Rural Aid FB: @ruralaidaustralia | IG:@ruralaid |IN: Rural Aid Ltd | TW: @ruralaidaust

Buy A Bale FB: @buyabaleofhay | IG: @buyabale | TW: @buyabale

ENDS

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RURAL AID AND EVOLUTION MINING BRINGING THE JOY OF MUSIC TO GAYNDAH SCHOOLS - PRWire

The Evolution Of The British Airways Livery – Simple Flying

Liveries are an interesting way to mark the time and history of an airline. In this article, we wanted to go over the evolution of the British Airways livery from its creation through the merger of several airlines through to today and the livery we are all used to seeing.

As you may have already known, British Airways was formed through the merger of several airlines: BOAC, BEA, NEA, and Cambrian. For quite a few years after the official merger, many of the aircraft kept their old colors and applied British Airways titles.

Then in 1974, the fleet was given a fresh look designed by firm Negus and Negus. British Airways described it as a modern and fresh design was based on the British national colors of red, white and blue. It featured a streamlined evolution of the BOAC and BEA insignia by way of a quartered Union Flag with a red tip on the tailfin and the Speedbird symbol on the nose.

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In 1980 there would be a slight change to the titling while in 1984, there would be experimentation with a silver top as you can see in the photos below (and their respective captions).

Designed by the famous design house Landor Associates, an updated scheme was unveiled in December 1984. It was quite similar to the Negus scheme, but the white roof was replaced with Pearl Grey and the belly replaced with Midnight Blue. The speedbird was replaced with a Brilliant Red speedwing running along the lower fuselage. The title font was also changed and capitalized.

Then, in 1996, some of the BA fleet began appearing with an odd lowered lighter blue belly without the speedwing. While the tail remained in the Landor scheme, the changes seemed to indicate that BA was preparing for a new livery and was unwilling to repaint aircraft into the old Landor scheme. This interim design appeared on several 737s, 747s, 767s, and A320s.

In 1997 British Airways unveiled its new World Images livery, designed to replace the Landor livery across the airline completely. Given the name Project Utopia, the livery intended to reflect the best of British values blended with the nations more modern attributes. The airline described it as friendly, youthful, diverse and cosmopolitan, open to many cultures.

As for the fuselage, the Pearl Grey upper was replaced with a bright white, and the blue belly was lowered and lightened. A new Speedmarque logo was added on the upper fuselage, and the titles moved under the window line.

One of the 1997 Project Utopia tails, also known as Chatham Dockyard was initially applied only to the Concorde. However, it became the standard BA tail livery after phasing out all other Utopia tails.

The design was based upon a stylized Union flag as flown by English naval commander Lord Nelson whos fleet was based at the historic Chatham Royal Dockyard. This remains as the airlines most current livery.

In 2012, British Airways repainted nine A319s with a dove design to mark the London 2012 Olympics. Additionally, British Airways created a distinctive yellow, orange, and gold livery for the aircraft that transported the Olympic Flame from Athens to London named The Firefly.

In early 2019 BA unveiled four special retro liveries to mark its centenary. The four designs were BOAC, BEA, Negus, and Landor. While the BEA design was painted on an Airbus A319, the other three designs were applied to Boeing 747-400s. The first image at the top of this article shows the four designs together.

Were you aware of all the different liveries that British Airways aircraft have worn? Let us know in the comments.

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The Evolution Of The British Airways Livery - Simple Flying

How the coronavirus escapes an evolutionary trade-off that helps keep other pathogens in check – The Conversation US

Viruses walk a fine line between severity and transmissibility. If they are too virulent, they kill or incapacitate their hosts; this limits their ability to infect new hosts. Conversely, viruses that cause little harm may not be generating enough copies of themselves to be infectious.

But SARS-CoV-2, the coronavirus that causes the COVID-19 disease, sidesteps this evolutionary trade-off. Symptoms often dont appear until after infected people have been spreading the virus for several days. One study of SARS-CoV-2 estimated that the highest rate of viral shedding, and therefore transmissibility, was one to two days before the person infected begins to show symptoms.

Put simply, you only feel ill once the virus has accomplished its evolutionary goal: to spread.

Viruses that are good at making copies of themselves, and then getting those copies inside new hosts, are more successful and become more prevalent until host immunity or public health efforts restrain them.

As professors who study evolutionary medicine, we know the trade-off between virulence and transmissibility helps keep a pathogen in check. The very destructiveness of a virus keeps it from spreading too much. This has been the case with other pandemic pathogens, including Marburg, Ebola and the original coronavirus responsible for SARS. Outbreaks that consistently cause severe symptoms are more easily corralled by public health measures because infected individuals are easy to identify. SARS-CoV-2, however, can invade communities stealthily, because many infected individuals have no symptoms at all.

Looking at it this way, COVID-19 resembles a sexually transmitted disease. The infected person continues to look and feel fine while spreading the illness to new hosts. HIV and syphilis, for example, are relatively asymptomatic for much of the time they are contagious. With SARS-CoV-2, recent research suggests that 40-45% of people infected remain asymptomatic. And those carriers seem able to transmit the virus for a longer period.

COVID-19 has another similarity to many sexually transmitted diseases. Its severity is not the same across hosts, and often its dramatically different. There is evidence that the ability to fight the infection differs among people. The severity among strains of the virus might also differ, though there is no solid evidence of this yet.

Even for a single strain of SARS-CoV-2, the virus can affect people in different ways, which could facilitate its spread. The SARS-CoV-2 virus or any other pathogen is not deliberately changing what it does in order to exploit us and use our bodies as vehicles for transmission, but pathogens can evolve to look like they are playing games with us.

Studies show pathogens can express conditional virulence meaning that they can be highly virulent in some individuals and less virulent in others depending on host characteristics, like age, the presence of other infections and an individuals immune response. This might explain how SARS-CoV-2 escapes the trade-off. In some individuals, virulence is maximized, such as in older hosts. In others, transmissibility is maximized.

Age, so far, seems the critical factor. Older people tend to get highly destructive infections, while younger hosts, although just as infectious, remain largely unscathed. This might be because different hosts have different immune responses. Another explanation is that as we get older, we are more likely to develop other illnesses, such as obesity and hypertension, which can make us more susceptible to harm from SARS-CoV-2.

Regardless of the mechanism, this age-based pattern permits SARS-CoV-2 to have its evolutionary cake and eat it too: ravaging older individuals with high virulence, yet maintaining younger individuals as vehicles for transmission. Some studies suggest younger people are more likely to be asymptomatic. Both presymptomatic and asymptomatic carriers can transmit the virus.

What do we know about the evolution of SARS-CoV-2? Unfortunately, not much yet. There is some evidence that the virus may be adapting to us as its new hosts, but so far no evidence shows that these mutations are causing changes in the virulence or transmissibility of SARS-CoV-2. And because SARS-CoV-2 may be able to circumvent the typical trade-off between virulence and transmissibility, there may be little evolutionary pressure to become less severe as it spreads.

For all the mysteries surrounding COVID-19, one thing is certain: We cannot be lulled into a false sense of security. As Sun Tzu warned in The Art of War, know your enemy. There is a great deal more to know about SARS-CoV-2 before we claim any victories.

[Youre too busy to read everything. We get it. Thats why weve got a weekly newsletter. Sign up for good Sunday reading. ]

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Cyclodextrin Market: Analysis by Sales Global Market Size, Segment and Evolution Rate by Type and Application Forecast to 2024 – Cole of Duty

Cyclodextrin Market gives an inside and out knowledge of Sales and Trends Forecast to 2019-2024:

The most recent report uploaded gives knowledgeable details on how customers can improve their essential leadership capacity inside the overall Cyclodextrin Market business. Use of charts and flowcharts are characterized in this report, the experts have represented the data in an unrivalled worthy way. This report distinguishes constantly changing business sector trends and competition with development in CAGR during Forecast. The report likewise contemplates the most recent marketing factors that are basic to record, market performance and vital choices for progress and productivity.

The prominent players under this report are: Wacker, NIHON SHOKUHIN KAKO, Ensuiko Sugar Refining, Yunan Yongguang Cyclodextrin Company, Qufu Tianli Medical Supplement, Shaanxi Liquan Chemical , Jiangsu Fengyuan Biotechnology , Mengzhou Huaxing Bio-chemical, MengZhouShi Hongji Biological , MicroBiopharm, Others

Cyclodextrin Market Segment by Product Types:

Significant Cyclodextrin applications along with their consumption forecast details:

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Cyclodextrin Market Research Report gives top to bottom data and expert analysis for the period 2019-2024. Cyclodextrin report shares details related to upstream crude materials, downstream interest, and production value with some significant factors that can prompt market development. Likewise, the Report is portioned into Manufactures, Types, Applications, and Regions.

The estimated period considering the market size of the Cyclodextrin is as follows:

Market Segmentation:The worldwide Cyclodextrin market is segmented based on the kind of item, application, and region. The examiners composing the report give a careful assessment of the entire segments, their share of the overall industry, income market development rate, and other indispensable variables. The segmented study prepares invested individuals to distinguish high-development segments of the worldwide Cyclodextrin market and see how the main leading segments can develop during the forecast time frame.

Primary Objectives of Cyclodextrin market Report:

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Table of Content

Chapter 1 About the Cyclodextrin Industry1.1 Industry Definition and Types1.1.1 -Cyclodextrin1.1.2 -Cyclodextrin1.1.3 -Cyclodextrin1.2 Main Market Activities1.3 Similar Industries1.4 Industry at a Glance

Chapter 2 World Market Competition Landscape2.1 Cyclodextrin Markets by Regions2.1.1 USAMarket Revenue (M USD) and Growth Rate 2015-2025Sales and Growth Rate 2015-2025Major Players Revenue (M USD) in 20192.1.2 EuropeMarket Revenue (M USD) and Growth Rate 2015-2025Sales and Growth Rate 2015-2025Major Players Revenue (M USD) in 20192.1.3 ChinaMarket Revenue (M USD) and Growth Rate 2015-2025Sales and Growth Rate 2015-2025Major Players Revenue (M USD) in 20192.1.4 IndiaMarket Revenue (M USD) and Growth Rate 2015-2025Sales and Growth Rate 2015-2025Major Players Revenue (M USD) in 20192.1.5 JapanMarket Revenue (M USD) and Growth Rate 2015-2025Sales and Growth Rate 2015-2025Major Players Revenue (M USD) in 20192.1.6 South East AsiaMarket Revenue (M USD) and Growth Rate 2015-2025Sales and Growth Rate 2015-2025Major Players Revenue (M USD) in 20192.2 World Cyclodextrin Market by Types-Cyclodextrin-Cyclodextrin-Cyclodextrin2.3 World Cyclodextrin Market by ApplicationsPharmaceuticalFood IndustryOthers2.4 World Cyclodextrin Market Analysis2.4.1 World Cyclodextrin Market Revenue and Growth Rate 2015-20192.4.2 World Cyclodextrin Market Consumption and Growth rate 2015-20192.4.3 World Cyclodextrin Market Price Analysis 2015-2019

Chapter 3 World Cyclodextrin Market share3.1 Major Production Market share by Players3.2 Major Revenue (M USD) Market share by Players3.3 Major Production Market share by Regions in 2019, Through 20253.4 Major Revenue (M USD) Market share By Regions in 2019, Through 2025

Chapter 4 Supply Chain Analysis4.1 Industry Supply chain Analysis4.2 Raw material Market Analysis4.2.1 Raw material Prices Analysis 2015-20194.2.2 Raw material Supply Market Analysis4.2 Manufacturing Equipment Suppliers Analysis4.3 Production Process Analysis4.4 Production Cost Structure Benchmarks4.5 End users Market Analysis

Chapter 5 Company Profiles5.1 Wacker5.1.1 Company Details (Foundation Year, Employee Strength and etc)5.1.2 Product Information (Picture, Specifications and Applications)5.1.3 Revenue (M USD), Price and Operating Profits5.2 NIHON SHOKUHIN KAKO5.2.1 Company Details (Foundation Year, Employee Strength and etc)5.2.2 Product Information (Picture, Specifications and Applications)5.2.3 Revenue (M USD), Price and Operating Profits5.3 Ensuiko Sugar Refining5.3.1 Company Details (Foundation Year, Employee Strength and etc)5.3.2 Product Information (Picture, Specifications and Applications)5.3.3 Revenue (M USD), Price and Operating Profits5.4 Yunan Yongguang Cyclodextrin Company5.4.1 Company Details (Foundation Year, Employee Strength and etc)5.4.2 Product Information (Picture, Specifications and Applications)5.4.3 Revenue (M USD), Price and Operating Profits5.5 Qufu Tianli Medical Supplement5.5.1 Company Details (Foundation Year, Employee Strength and etc)5.5.2 Product Information (Picture, Specifications and Applications)5.5.3 Revenue (M USD), Price and Operating Profits5.6 Shaanxi Liquan Chemical5.6.1 Company Details (Foundation Year, Employee Strength and etc)5.6.2 Product Information (Picture, Specifications and Applications)5.6.3 Revenue (M USD), Price and Operating Profits5.7 Jiangsu Fengyuan Biotechnology5.7.1 Company Details (Foundation Year, Employee Strength and etc)5.7.2 Product Information (Picture, Specifications and Applications)5.7.3 Revenue (M USD), Price and Operating Profits5.8 Mengzhou Huaxing Bio-chemical5.8.1 Company Details (Foundation Year, Employee Strength and etc)5.8.2 Product Information (Picture, Specifications and Applications)5.8.3 Revenue (M USD), Price and Operating Profits5.9 MengZhouShi Hongji Biological5.9.1 Company Details (Foundation Year, Employee Strength and etc)5.9.2 Product Information (Picture, Specifications and Applications)5.9.3 Revenue (M USD), Price and Operating Profits5.10 MicroBiopharm5.10.1 Company Details (Foundation Year, Employee Strength and etc)5.10.2 Product Information (Picture, Specifications and Applications)5.10.3 Revenue (M USD), Price and Operating Profits5.11 Others5.11.1 Company Details (Foundation Year, Employee Strength and etc)5.11.2 Product Information (Picture, Specifications and Applications)5.11.3 Revenue (M USD), Price and Operating Profits

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Cyclodextrin Market: Analysis by Sales Global Market Size, Segment and Evolution Rate by Type and Application Forecast to 2024 - Cole of Duty

PHA INDUSTRY MARKET 2020-2025 INDUSTRY EVOLUTION FACTS AND FIGURES – 3rd Watch News

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The Global PHA Industry Market Research Report market research report delivers key statistics, such as CAGR, growth rate over the forecast period, for providing a clear picture to the industry players. In addition, the researchers have also focused on the trending aspects that will guide the manufacturers for managing their production quantity, supply and chain, import and export, distribution channel, product price, and more. To help the industry players with more information, experts have also stressed on the reasons of market growth, probable challenges, and highlights on the government regulations and environment policies.

Special focus on the restraining factors and challenges in the industry are well elaborated by the researchers that will avoid the barriers, reduce wastage, and streamline the business operations significantly. Moreover, accurate data on the market essentials will also save time for the managers, strategy planners, and marketing executives so that they plan more effective strategies for considerable growth in the near future. Marketing personnel and strategists can effectively finalize crucial decisions for business operations and maintaining relations with customers simultaneously.

Geographical Analysis:

Geographically, the research report on the Global PHA Industry Market Research Report market is segmented into North America, South America, Asia Pacific, Europe, and Middle East and Africa. Highlights on the exact market scenario in each region are delivered through this report. The report also offers insights on product preference in each region, including details on product price, import and export status, trending factors, and demographic information, such as age, gender, and income.

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Competitive Analysis:

For the industry players to gain competitive advantage, the report offers thorough analysis on recent strategies adopted by the key players, latest news on the developments, government policies on import and export, and more. Market players can effectively plan their next move and gain prominent position in the near future. Also, the report covers recent news in the industry that will give an idea of the current market scenario and enable them to expect the next upcoming product or technology.

Top Companies in Global PHA Industry Market Research Report Market:

Expect the answers to the following questions through the report:

Which factors are expected to limit the event of the worldwide market?

Which are the key players operating within the global market?

What are the most factors likely to encourage the expansion of worldwide Soil Stabilization Market?

What are the projected values and rate of growth of the worldwide Soil Stabilization market?

Which application and merchandise segments are anticipated to top within the forecast period?

Which geographical segment is predicted to steer and hold main share of the worldwide market within the next few years?

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PHA INDUSTRY MARKET 2020-2025 INDUSTRY EVOLUTION FACTS AND FIGURES - 3rd Watch News

Watch The Porsche Boxster And Cayman Evolve From Their Debut To Current Day – Motor1

The Porsche Cayman and Boxster are the mid-engine little brother to the larger and more expensive Porsche 911. The Boxster and Cayman have spent most of their time living in the shadow of the big brother 911, however, these cars have been a critical part of the success and survival of the Porsche brand. Today we take a quick history lesson courtesy of Cars Evolution, a YouTube channel that, is dedicated to showing the evolution of our favorite cars.

The Porsche Boxster debuted in 1996 and ushered in a new age for the Porsche brand. This water-cooled convertible was built to pay homage to the classic 356 Roadster of the 1960s and offered drivers precise handling balance. Power by a 2.5-liter flat-6 engine, the original Boxster was not a fast car but a great platform for higher performance trims of the future. Over time the Boxster grew in size and capability and in 2006 the fixed roof Cayman was born. The Cayman was the coupe version of the Boxster and allowed Porsche to cater to even more customers with the same platform.

Many Porsche enthusiasts have a tumultuous relationship with the Boxster and Cayman who feel a 911 is the only Porsche the matters. Porsche seemed to feel the same way as the Boxster and Cayman always left a little performance on the table to protect the 911s performance credibility. That all changed with the the Porsche Cayman GT4, which debuted in 2016. This high horsepower Cayman feature real aerodynamics and parts for the high-performance 911 GT3 to create the ultimate mid-engine Porsche.

Today the Boxster and Cayman continue to grow and evolve into their own unique offering alongside the larger and more powerful 911. Many Porsche enthusiasts have found room in their garages to own both 911s and Boxster or Caymans, while used Boxsters and Caymans are also a great way to enter into the Porsche brand.

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Drill Pipe Market Highlights On Evolution 2025 Cole Reports – Cole of Duty

Global Drill Pipe Market: Snapshot

Drill pipes are hollow pipes, usually made of aluminum alloys or steel and are a core component in the drilling process. The hollow drill pipes enable for the transfer of drilling fluids downwards towards the drill point or back upwards through the annulus. Although a standard length for drill pipes is up to 32 feet, there are longer pipes that could stretch till 45 feet and are used in special circumstances.

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Most stems in drilling systems need to be created in a way that allows for efficient drilling torque transfer that can be sent downward, over many miles and through the Earths crust. In order to do this, the pipes need to be able to withstand the massive pressure exerted by the ground towards the outer walls of the pipe, as well as the pressure exerted by the fluids from within. This involve the use of tempered steel tubes that can be expensive in nature. Due to this, the reusability of drill pipes is a highly regarded quality that could end up hampering the overall demand rates for them.

Global Drill Pipe Market: Overview

Drill pipes, usually made from aluminum or steel, are hollow and thin-walled and utilized indrillingrigs. Drillingfluid is pushed down the hole and back up the annulus. They are available in the market in different sizes, strengths, and wall thicknesses. Their length is usually between 27 and 32 feet. They can withstand massive internal and external pressure, distortion, bending, and vibration as they can rotate and lift the bottom hole assembly (BHA). The two types of drill pipes are standard drill pipes and heavy weight drill pipe.

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Global Drill Pipe Market: Key Trends

At the forefront of driving growth in the global drill pipe market is the spiking demand for energy, which has necessitated exploration of offshore reserves on account of tanking production from onshore fields. The progress in drilling technologies such as pad drilling and horizontal drilling have also helped up output and lowered drilling rig downtime, which has expedited drilling operations. This is slated to push up demand even further.

Countering the growth in the global drill pipe market is the tanking crude oil prices. This has also resulted in a steady decline in rig rental capital in the offshore market. Customers now have strong bargaining power in negotiating new contracts and extensions too on account of the downward pressure on prices.

Global Drill Pipe Market: Market Potential

At present there are way too many offshore drilling rigs chasing too little work. Hence, many are being idled or scrapped. Offshore opportunities, however, are abound in Africa and the Middle East that provide an avenue for growth for the market. The onshore oil and gas presents much greater opportunity than the offshore ones because the explosive drilling activities from shale reserves, coal bed methane, and tar sands. Additionally, the continued spike in global petroleum consumption is also predicted to create major growth opportunities for the market in the near future.

Going forward, the premium grade drill pipe segment is slated to hold out a lot of potential because of the growth in the exploration activity in deepwater and ultra deepwater regions primarily in Europe and Africa, where recent oil and gas discoveries have occurred in the offshore regions. Premium grade drill pipe is helpful in deepwater exploration on account of it being immune to high pressure and high temperatures.

Global Drill Pipe Market: Regional Outlook

From a geographical perspective, North America is a key region on account of the burgeoning shale gas exploration and production in the U.S., which has favored the drill pipe market and will continue doing so in the near future. Canada is another important market in the region. The Middle East and Africa are other crucial markets on account of the presence of a large number of reserves.

In terms of growth, however, Asia Pacific, powered by China, will outshine all other regions. This will be mainly on account of the flexible and hassle-free regulatory scenario in the countries of China, India, Indonesia, and Singapore.

Global Drill Pipe Market: Competitive Analysis

Some of the prominent players in the global drill pipe market are Superior Manufacturing, Tenaris S. A, Drill Pipe International, Oil Country Tubular Limited, Texas Steel Conversion, Inc., Hilong Group of Companies, TMK Group, DP Master, Vallourec S.A., Tejas Tubular Products, Inc., Jiangyin Long Bright, National Oilwell Varco.

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Drill Pipe Market Highlights On Evolution 2025 Cole Reports - Cole of Duty