In this new interview, David Sinclair, Harvard professor and the author of Lifespan, explains his theory of aging, shares parts of his health routine, and reveals which directions in todays aging research excite him.

In the longevity field, when it comes to name recognition, theres David Sinclair and all the rest. Like in many other areas, this gap in popularity doesnt necessarily reflect the actual professional hierarchy. Dr. Sinclair, a Harvard professor, is undoubtedly a very prominent aging researcher, but he would probably agree (although we didnt ask) that he has many equally worthy colleagues.

Some of Dr. Sinclairs popularity stems from his highly successful Lifespan: Why We Age and Why We Dont Have To, a great entry-level book that did a lot to introduce the science of aging and the ideology of life extension to the public consciousness. Now, a new book is in the works, and it differs from the first one, Dr. Sinclair told us, in that Lifespan is the textbook, Lifespan II is the guidebook. That probably means we can expect some expert wisdom on how every one of us can stay healthier and live longer. Dr. Sinclair maintains an interesting personal routine, which we also asked him about.

Today, Dr. Sinclair is one of the most visible longevity advocates, expertly broadcasting the message of life extension from top-tier platforms such as Joe Rogans and Peter Diamandis podcasts. He carefully chooses his appearances at conferences, where he receives rock star-like attention.

All this does not mean that Dr. Sinclair has completely morphed into a public figure. On the contrary, he and his team at Harvard continue to produce some of the most interesting results in the field, which we have covered extensively. He is one of the pioneers in practical applications for partial cellular reprogramming, having demonstrated that it can regenerate crushed optic nerves in mice and non-human primates.

Like many high-profile researchers, Dr. Sinclair has his pet theory of aging. The current ruling paradigm is the Hallmarks of Aging, the processes that include genomic instability and telomere attrition. Together, they are responsible for the phenotype of aging that we are all familiar with. Scientists know that many if not all these processes are interconnected, but is there an actual hierarchy?

Dr. Sinclairs answer to that is yes. According to his Information Theory of Aging, cells health and function depend heavily on epigenetic information, a set of instructions in the form of slight chemical alterations to DNA molecules that governs the expression of genes and other elements of our DNA, such as retrotransposons. This is what tells cells into which cell type they should differentiate and how they should perform this types duties.

With time, various stressors throw our epigenome into disarray. Imagine pages of a manual being accidentally torn out, having coffee spilt over them, and so on. Epigenetic alterations are indeed one of the Hallmarks of Aging, and their contribution to aging is widely acknowledged. However, Dr. Sinclair takes it one step further.

First, those changes, he says, are responsible for a very significant part of aging that is, they are high upstream and influence many or all other hallmarks. Second, he postulates that there is a copy of the manual that can be used to restore the epigenome to its youthful state. We can see hints to this in cellular reprogramming, where cells can be either thrown back to their pluripotent (undifferentiated) state and almost completely rejuvenated, or partially reprogrammed and partially rejuvenated.

If we can find that pristine backup copy of cellular epigenetic information and learn how to use it, the possibilities are endless. A recent study by Sinclair et al. presents findings in support of the theory. Its not conclusive evidence yet, but definitely hope-inspiring. For more on this and other topics, we turned to David himself, and he kindly agreed to answer a few questions.

According to the Information Theory of Aging, epigenetic changes that disrupt gene expression patterns as we age are driven by cell stress and damage, such as DNA breaks. This process causes cells to lose their function and identity, to become exdifferentiated, and this may be a cause of many of the changes seen during aging, including some major age-related diseases.

Its not yet known how potent the effects of in vivo epigenetic reprogramming will be. We know it can improve the function of the eye to cure blindness in mice and monkeys and even improve the function of the brain, but whether it can fix the many problems that occur with age in the human body is not known.

The hypothesis predicts that there is chemical information in cells that encodes the youthful structure of the epigenome so that it can be reset, and gene expression can be restored to an earlier age. We know that it is possible to reset gene expression. We dont yet know for sure how and where this information is stored, but we are working hard to find these answers.

The hypothesis is that the backup copy stores the cells youthful chromatin structure that controls which RNAs and proteins are expressed. Resetting these structures allows the cell to regain its differentiated state and its youthful functions.

The hypothesis is that rejuvenation is important for germ cells and embryos to maintain youth. We speculate the putative backup copy is also important for the rebuilding of damaged organs and tissues. Many species can regrow entire body parts, from limbs to heads. With the exception of our livers, which can regrow after damage or surgery, we humans have largely lost the ability to regrow organs and limbs.

Species that live a long time are known to have a more stable epigenome than those that live shorter. We suspect this might be because they are better at preventing and repairing DNA damage, which we have shown can accelerate age-related changes.

Antagonistic pleiotropy is a process that is advantageous when organisms are young, but they cause problems later in life, when the force of natural selection is so weak they continue to exist in the germline. The processes that disrupt the epigenome seem to be useful in young organisms because they recruit chromatin factors to sites of broken DNA and increase DNA repair and stabilize chromosomes. We first saw this in yeast cells in Lenny Guarentes lab in the late 1990s, then later in mammals, in my own lab in the 2000s. The problem is that the recruitment doesnt reset fully, and chromatin regulators lose their place on the genome, causing exdifferentiation of cells. In 2007, we called this the Relocalization of Chromatin Hypothesis of Aging or RCM, and it was later incorporated into the Information Theory of Aging.

We have not seen any evidence for this claim after a decade of studying the system, the results of which are in the paper showing cells do not experience cytotoxicity. Our detailed response to the claim has been published in Cell.

We have a long way to go. Most people havent heard of aging research or the results that are being produced. Most doctors are also unaware of the advances in the field.

I think our biggest bottleneck is having access to old mice that we can study. One solution would be to have a source of them for all researchers.

Saying there is no known upper limit doesnt mean we can live for decades or centuries longer. I dont know of any technology that would allow Longevity Escape Velocity currently, but I also know saying something is impossible is a dangerous thing in this time of human history.

Im excited about senolytics, epigenetic reprogramming, and the use of AI in healthcare.

I have hopes we will be able to rejuvenate people in the next few decades. If all goes well, Life Biosciences will be testing vision restoration in humans in 2025.

Im not simply relying on anecdotes. Changing my lifestyle has resulted in changes to my blood biomarkers that are consistent to long-term health. Vegan diets are considered some of the healthiest of all, and this is backed by multiple human studies. Skipping meals so that my eating window is shorter, which is what I try to do, is backed by evidence indicating that it improves metabolic health and lowers inflammatory markers, among other benefits.

We know their safety profile. Metformin has been in tens of millions of people. Metformin and low-dose rapamycin appear to be relatively safe. Whether they are effective at slowing aging and safe in combination is not yet known.

After this interview was taken, David Sinclair has stepped down as President of the Academy for Health & Lifespan Research, as announced on X by another co-founder, Nir Barzilai.

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David Sinclair on Solutions Within Decades - Lifespan.io News

The 2024 Speedgoat by UTMB 50k kicked off at 6:30 a.m. local time on Saturday, July 20, high in Utahs Wasatch Mountains at the famous Snowbird ski resort. Once all 32 miles (52 kilometers) and 11,000 feet (3,400 meters) of climbing were complete, David Sinclair had a new course record, while Canadas Jazmine Lowther led the womens race from wire to wire.

The weather was truly typical for a high-altitude summer day: fresh crispness in the morning, eventually yielding to a full sun whose heat always feels stronger at altitude.

Sinclairs no-contest treatment of both the course and the mens field showed that he was far-and-away the best mens runner of the day. Samuel Hendrys (Canada) performance for second place, while holding that position for basically the whole race, was also dominant.

And for Lowther, though the womens race ran more closely, she, too, showed strength to stay ahead of a big chasing field, including significant pressure from second place by Mali Noyes, who made her presence known in the second half of the race.

Read on for more of this years Speedgoat 50k story.

The start of the 2024 Speedgoat by UTMB 50k. Photo: Nils Nilsen

It was a tight start to the mens race, but that didnt last long. Through the first checkpoint at mile four, a group of eight men rolled through within a minute of each other. Then, at about mile nine and the top of the first major climb, the summit of 11,000-plus-foot Hidden Peak, two men, David Sinclair and Samuel Hendry (Canada), who would ultimately go one-two at the finish, passed through together, with more than two minutes on the rest of the field.

Sinclair is familiar with this race, having finished it three times and won it twice before, as recently as 2022. Hendry, an elite cross-country skier and skilled shorter-distance trail runner, looked to be moving up in distance with this race.

Behind them at mile nine, the top-10 men had strung out to within seven minutes of the lead. Among that group and pushing the pace was Adam Peterman, a prior Speedgoat 50k champion and the then course record holder, and Scott Patterson, a two-time Olympian in cross-country skiing and a mountain runner.

From here on, though, it was the Sinclair show, as at each checkpoint, his gap on Hendry as well as the rest of the field increased. By mile 20 at the Mineral Basin checkpoint, on the backside of Snowbird ski resort, Sinclairs lead was just shy of nine minutes, and it only extended from there.

For the races final third, it was only the clock that Sinclair raced. When he crossed the line, after summiting Hidden Peak a second time, racking up a boatload of vertical, and taking the fast-and-furious descent back to the base of the ski resort, David Sinclair won in 4:57:35. This broke the previous course record of 5:04:31 set by Peterman in 2021. Sinclair also shaved over 11 minutes off his previous time when he won the race in 2022.

David Sinclair on his way to winning and setting a course record at the 2024 Speedgoat 50k. Photo: Nils Nilsen

Onto the rest of the mens race. For as dominant as Sinclair was in first place, so was Hendry in second. By mile 20, Hendry had built a four-minute lead over the rest of the field, which he would hold at each aid station until the finish. Samuel Hendry ultimately crossed the finish line comfortably in second place in 5:24:57, with more than seven minutes on the next chasing man.

At every single aid station, it was Patterson holding a strong third place. So when the Olympian Scott Patterson crossed the line in third with a time of 5:32:26, it should not have come as surprise ending.

David Hedges took fourth in 5:38:35 and Grant Barnette fifth in 5:45:56.

Early pace pusher Peterman ultimately found his way to the finish in sixth.

Scott Patterson crossing the 2024 Speedgoat 50k finish line in third place. Photo: Nils Nilsen

Full results.

While the womens race for the win ran much more closely than in the mens, Canadas Jazmine Lowther took the lead from the get-go, never gave in as women ran closely behind her, and put the hammer down to crush the final descent and the rest of the womens field. Lowther was coming to this race after recovering from a longer-term injury that followed a pretty incredible couple years of ultrarunning, which saw her win the 2022 Canyons by UTMB 100k and take second at the 2023 Transgrancanaria.

To look at Lowthers lead over her closest chaser, as the race progressed, it bounced from about a minute at the first checkpoint at mile four and over Hidden Peak for the first time at mile nine, before growing to more than 3.5 minutes by mile 20. She gave back some of that time in the next five rough and verty miles, holding just an 80-second lead when she summited Hidden Peak for the second time at mile 25 and began the big descent to the finish.

Over those final seven-ish miles, Lowther put six minutes on second place. That cracking descent from Jazmine Lowther ensured her victory and she crossed the finish line in 6:15:05.

Jazmine Lowther, 2024 Speedgoat 50k champion. Photo: Nils Nilsen

The race for the rest of the womens top five was highly dynamic, with women moving around for much of the race. The closest chasers at the first checkpoint at mile four were Emkay Sullivan and Martina Valmassoi (Italy), the former of whom would remain dominant all race and the latter of whom would need to drop due to physical issues.

After over 6,000 feet of climb since the start of the race, over the first summit of Hidden Peak at mile nine, Emily Caldwell also made her presence known, passing over Hidden Peak in second place, with Sullivan right there in third.

Over the next 11 miles, another runner presented herself a challenger, Mali Noyes, a prior two-time finisher who took second last year. The cross-country and downhill skier at least partially converted to trail running a few years ago, and has been racking up experience in American trail races. Noyes moved into second place for the women before mile 18 and then held it to the finish. Mali Noyess impressive climb up the leaderboard in the first half, before holding steady in the races second half, led her to finish in second place in 6:22:31.

Much like Noyes in second place moved into that position before mile 18, so did ultimate womens third-place finisher Kodi Kleven. Kleven is a local runner, coach, and former collegiate runner who finished seventh at last years Speedgoat 50k, so she was looking to move up this year.

And also like Noyes, Klevens gap on the rest of the field stayed fairly close and fluctuated. For Kleven, her breakaway from the rest of the field took place on the beefy climb back up to Hidden Peak for a second time at mile 25. There, Kleven had carved out a fairly comfortable seven-minute lead, which she extended to 11 minutes by the finish line. Kodi Kleven crossed the finish line in 6:24:12 for third place.

Emkay Sullivan ultimately finished fourth in 6:35:09. Lindsay Allison also moved up during the latter half of the race, finishing in fifth in 6:41:39.

Kodi Kleven finishing third at the 2024 Speedgoat 50k. Photo: Nils Nilsen

Full results.

Read the rest here:
2024 Speedgoat by UTMB 50k Results: Sinclair Sets Record, Lowther Wins - iRunFar

A new review authored by three acclaimed geroscientists paints a promising picture of past and ongoing human clinical trials of prospective anti-aging drugs [1].

The biology of aging is an exciting new field, but most of its successes have been in animal models, from the early breakthroughs in yeast [2] and nematode worms [3] to the robust findings by the ITP (Intervention Testing Program) in mice [4]. Human data, however, is much scarcer. Some potentially geroprotective interventions, such as cellular reprogramming, are brand new, so they are yet to be tested in clinical trials. Others are well-known drugs that have been in use for various indications, and we have reasons to believe that they might also prolong human lifespan.

In this new review published in Cell Metabolism, three renowned aging researchers David Sinclair of Harvard, Leonard Guarente of MIT, and Guido Kroemer of Universit Paris Descartes summarized the current state of affairs in human trials of potentially geroprotective drugs. They focused on eight categories: metformin, NAD+/sirtuins, GLP-1, rapamycin, spermidine, senolytics, probiotics, and anti-inflammatories. After providing a brief overview of the related compounds and their mechanisms of action, the authors delved into past and ongoing trials.

Metformin was isolated decades ago from French lilac, which is a traditional anti-diabetes medication. However, it has only been used widely since the 1990s, to great success. Interestingly, it remains unclear how exactly metformin helps diabetes patients, but the leading theory is that it weakly inhibits mitochondrial respiratory complex I, which via the activation of AMPK kinase lowers glucose production and stimulates mitochondrial activity. However, other explanations have been proposed.

Metformin became gerosciences darling after a 2014 study showed that diabetes patients on metformin tended to live longer than age-matched healthy people. A recent 2023 study questions this assumption, but the authors interpret its results as less than a death blow to metformins prospects as a geroprotective drug.

So far, in human trials, metformin has been shown to protect heart function in diabetics, improve immune function (in a small-scale trial), and lower one marker of inflammation (CRP), but not another marker (IL-6). The authors also note that metformin slightly dampens the effects of aerobic exercise, probably due to attenuation of mitochondrial function. However, it is not clear at this point whether it should be seen as a serious problem for people who exercise a lot.

NAD+ is a ubiquitous and multi-purpose molecule that mediates energy production and serves as a substrate for the family of enzymes called sirtuins. Sirtuins play various roles, including in DNA repair and mitochondrial maintenance, and their activation has been shown to extend lifespan in numerous animal models. In addition to NAD+ supplementation, some sirtuins can be activated directly by compounds such as resveratrol, quercetin, and fisetin.

Human trials on the NAD+ precursors NMN and NR have shown that those can reliably elevate NAD+ levels. One NMN trial led to higher physical performance and lower biological age in middle-aged adults. Two trials of SIRT1 activator pterostilbene demonstrated improved liver function. MIB-626, an NMN polymorph developed by Sinclairs company Metro Biotech, was found to improve lipid profile and diastolic blood pressure. NR trials in patients with Parkinsons, Alzheimers, or ALS have shown some promise, and many more trials are currently running.

GLP-1 is a hormone produced in response to food intake and it is known to stimulate insulin secretion and mediate satiety. GLP-1 receptor agonists, such as semaglutide, liraglutide, and tirzepatide, are novel anti-diabetes drugs that have become widely popular due to their impressive effectiveness in promoting weight loss.

Since diabetes and obesity are strongly associated with one another and with various diseases of aging, GLP-1R agonists have the potential to be highly effective anti-aging agents. Accordingly, two large trials showed that semaglutide and liraglutide improve cardiovascular function and decrease cardiovascular mortality. Two other studies demonstrated some positive effects of GLP-1R agonists in Parkinsons patients.

Rapamycin is yet another FDA-approved medication that has been around for many years. It is mostly used as an immunosuppressant, but it has also been found to extend lifespan and healthspan in various animal models, including mice, even when given late in life. Rapamycin works by inhibiting mTOR, a protein complex that mediates protein production and cell growth.

Studies of everolimus, a rapamycin analog, showed increased immune response to influenza vaccination and lower infection rate over a one-year period, which is somewhat surprising given that rapamycin is an immunosuppressant. The authors suggest that everolimus, which selectively targets only one of the mTOR components, TORC1, might be less toxic. Rapamycin was also shown to reduce a subset of pro-inflammatory T cells in lupus and to cause some skin rejuvenation.

The authors, however, emphasize rapamycins side effects. By slowing protein synthesis, it probably blunts the effects of exercise and slows wound healing, among other things. Just like metformin, rapamycin might be ill-advised for people with high levels of physical activity, although this remains to be seen.

Spermidine is a natural metabolite of the polyamine family that has been found to increase lifespan in animal models, including in mice, albeit modestly, compared to rapamycin. Spermidine is known to induce autophagy, the process of clearing out accumulated cellular junk such as misfolded proteins.

Since autophagy targets protein aggregates, including amyloid beta, spermidine has been tested for possible cognitive function effects and shown to improve cortical thickness and hippocampal volume in older adults. Two other studies demonstrated cognitive improvements.

Spermidine is found in food, so populational studies are possible. Two retrospective studies, from Italy and Austria, reported inverse correlation between spermidine intake and mortality.

Senolytics are a completely new class of drugs that didnt exist just several years ago. They supposedly clear out senescent cells those that became dysfunctional and stopped proliferating, but remain in the body, causing inflammation and other types of harm.

Despite the amount of interest in senolytics both in academia and in the private sector, completed human trials are still very sparse. The authors mention mostly those that show the ability of senolytics to clear out senescent cells. However, many trials are underway, so stay tuned. Interestingly, the review does not mention the failure in 2020 of UNITYs lead senolytic candidate, UBX0101.

The importance of microbiome for aging is a relatively new finding. Studies have demonstrated that aging changes gut microbiota composition and that transplanting young microbiota confers various health benefits and can increase lifespan in progeroid mice.

Probiotics have been demonstrated to improve immune function, increasing the number of T cells and lowering the number and duration of common infectious diseases. Several studies have reported that a healthier microbiome can improve cancer outcomes.

Microbiota naturally have a big impact on metabolism. Beneficial bacteria (mostly Lactobacillus and Bifidobacterium) can improve lipid profiles and increase insulin sensitivity. Probiotics can also lower inflammation and improve cognitive function.

Finally, since chronic inflammation is one of the hallmarks of aging, the whole formidable arsenal of anti-inflammatory drugs, including steroids, analgesics, and monoclonal antibodies against particular inflammatory molecules, have considerable anti-aging potential. Most of the completed trials, according to the authors, deal with the inflammatory cytokine IL-6. Reducing its levels has been shown to improve the symptoms of irritable bowel disease and ulcerative colitis.

The authors, however, warn about tinkering with inflammatory cytokines, since those mediate immune responses. One study reported that treatment with tocilizumab, an IL-6-neutralizing antibody, leads to an increase in infections. Among other anti-inflammatories, the good old aspirin is featured in several ongoing trials, including for prevention of cancer in at-risk patients. One completed trial found that aspirin was associated with lower mortality in people at least 70 years old. As with other drug categories mentioned in the review, there are numerous ongoing trials of anti-inflammatory agents.

Aging research over the past three decades has unveiled numerous pathways that may be targeted for interventions to slow aging processes and their accompanying diseases. This review has sketched out some of the leading candidates under current scrutiny, although it is possible that other approaches will reveal themselves in the future. We believe that the next few years will present a tipping point, when the most viable approaches will become evident and move us toward a more widespread use of interventions targeting aging processes. While aging is not a disease as prescribed by the FDA, one might expect approval of these interventions to treat aging-fostered diseases.

To do this, we need your support. Your charitable contribution tranforms into rejuvenation research, news, shows, and more. Will you help?

[1] Guarente, L., Sinclair, D. A., & Kroemer, G. (2024). Human trials exploring anti-aging medicines. Cell Metabolism.

[2] Kaeberlein, M., McVey, M., & Guarente, L. (1999). The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms. Genes & development, 13(19), 2570-2580.

[3] Kenyon, C., Chang, J., Gensch, E., Rudner, A., & Tabtiang, R. (1993). A C. elegans mutant that lives twice as long as wild type. Nature, 366(6454), 461-464.

[4] Harrison, D. E., Strong, R., Sharp, Z. D., Nelson, J. F., Astle, C. M., Flurkey, K., & Miller, R. A. (2009). Rapamycin fed late in life extends lifespan in genetically heterogeneous mice. nature, 460(7253), 392-395.

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David Sinclair on Human Trials of Anti-Aging Compounds - Lifespan.io News

On Wednesday, Dr Nir Barzilai, one of the co-founders of the Academy for Health & Lifespan Research took to X (formerly known as Twitter) to announce that Dr David Sinclair, also a co-founder of the Academy, had resigned as President.

Sinclair, who is Professor of Genetics at Harvard Medical School, had been chosen by his peers for the position in June of last year, succeeding Dr Felipe Sierra (now Chief Science Officer at Hevolution).

Longevity.Technology: The Academy for Health & Lifespan Research (AHLR) is dedicated to studying the mechanisms of aging and developing interventions to slow and reverse the process. With a current membership of 60 of the worlds foremost researchers and geroscientists, it elects members annually based on their scientific contributions and commitment to the community.

Barzilai made Wednesdays announcement on behalf of Eric Verdin, Laura Neiderhofer, Andre Bertram and himself. He thanked Sinclair for his service, and indicated that the academys Executive Director Risa Starr will temporarily handle the administrative responsibilities of the Presidency until its board can confirm a new president. Barzilai also asked members of the academy to immediately submit their nominations, either for others or themselves, and said the academy plans to announce the new president at its meeting on 3rd April.

We regret all the events that led to Davids resignation and take the lessons to heart, wrote Barzilai in his tweet. We hope we can move past these events. The Academy is about science and scientists; all else is secondary [1].

He added that the academy has decided to postpone its 2024 election of new members until after the confirmation of its next president.

Sinclairs resignation comes a week-and-a-half after former academy member Dr Matt Kaeberlein tweeted that after careful consideration he was renouncing his academy membership, citing ongoing behavior by Academy President Dr. David Sinclair that I find both personally and professionally unacceptable [2].

Commenting on Wednesdays announcement of David Sinclairs resignation, Longevity.Technology CEO and founder Phil Newman said: Strong personalities are important in the early stages of a new industry some lead, some challenge, and some both lead and challenge; either way, we need to thank these individuals for their contributions and preparedness to take the lead publicly. This exposure brings the benefits of social followers and commercial opportunities, but it also brings the challenges of scrutiny.

[1] https://twitter.com/NirBarzilaiMD/status/1767981636405043227 [2] https://twitter.com/mkaeberlein/status/1764361555557380198

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David Sinclair resigns as President of the Academy for Health & Lifespan Research - Longevity.Technology

The Wareham Library Foundation is laughing all the way to the bank.

The foundation raised $5,484 at its second annual Comedy Night fundraiser on Saturday, May 6.

Were trying to reach different people to support the library, said Wareham Library Foundation President Eileen Scully.

About 70 people came to Stone Path Malt on Kenrick Road for food, beer, cornhole, ping pong, the Kentucky Derby and, most importantly, live comedy.

Three Massachusetts comedians performed: Host Pat McLoud from Weymouth, David Sinclair from New Bedford and headliner Chris Zito from Boston, who hosts a radio morning show on Mix 93-1 in Springfield and 96-1 SRS in Worcester.

The comedians performed some South Coast-specific humor, including a joke from Sinclair about his hometown of Fall River and the imprisonment of former mayor Jasiel Correia. The most popular topics for jokes were marriage and children.

Its like talking to an oak tree, Zito joked about his less-than-chatty 17-year-old son.Who is that kid?

Marion resident Gayle Santello said Zito was her favorite of the three comedians, and she loved having an opportunity to get out and laugh.

Its been kind of a stressful week, she said, and this is just what the doctor ordered.

She appreciated being able to support the library at the same time.

Libraries, when I was growing up, [were] my safe space, Santello said. I dont know what I would have done without the library.

The Wareham Library Foundation was founded in 2007 to raise funds for the Wareham Free Library. About 20% of the librarys overall funding comes from the foundation, which helps pay the salaries of the librarys part-time employees.

Along with proceeds from ticket sales, the foundation raffled off prizes, many of them donated by the 16 area businesses that sponsored Comedy Night.

Prizes included gift cards, bottles of wine and sports memorabilia, such as a hockey puck signed by Jake DeBrusk of the Boston Bruins.

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Comedy Night benefits Library Foundation | Wareham - Wareham Week

The ones who have raged with vitality against the dying of their lifes light have often raised as many questions as they have provided answers on longevity.

What does it take to age well? Getty

Frenchwoman Jeanne Calment, and claimed her breasts remained as firm as two little apples, ate half a kilo of chocolate a week as well as drinking a glass of port each evening. British World War I veteran Henry Allingham suggested he had made it to 113 thanks to cigarettes, whisky, and wild, wild women. US World War II veteran Richard Overton, who lived to 112, that one secret to his long life was smoking cigars and drinking whisky, as he often did on the porch of his Austin home.

These centenarians are not poster children for the longevity secrets of sugar, tobacco and hard liquor. Rather, they are .

And, sadly for the rest of us, to hasten the end of our life, or at the very least, our health span.

Centenarians live longer because they get chronic diseases 20 to 30 years later than everybody else, says Dr Peter Attia, the author of the New York Times non-fiction bestseller, Outlive. Now their genes do that for them. [But] were going to have to use medicine, nutrition, sleep, exercise, etc to delay the onset of those chronic diseases.

So, how perfect do we have to be to do that? And how much room is there to have fun in our lives without compromising our health?

I guess it depends on what you consider fun, Attia tells me. Say my definition of fun is heroin and cocaine, then theres probably not a lot of room for fun because I think those risks are pretty high. Or if a person says, my idea of fun is never exercising, then its going to be really hard.

But Attia insists we dont have to be pristine to extend our health span.

I certainly dont consider myself a monk when it comes to food, says Attia, who adds that alcohol, for instance, is not good for us at any dose. But does that mean we should never, ever consume it? My view is if it gives you pleasure, it gives me pleasure.

He limits his favourite drinks tequila and red wine to four a week and tries not to drink within three hours of bedtime, so it doesnt disrupt his sleep. He adopts the same attitude of moderation towards chocolate or other foods that we enjoy.

I am no longer a dogmatic advocate of any particular way of eating, he writes, adding that the idea there is one perfect diet that works best for everyone is absolutely incorrect. Rather, he focuses on whether we are under or over-nourished, under or adequately muscled; and metabolically healthy or not.

What he is monk-like about is exercise, which includes , recommending that we move more than the bare minimum of the physical activity guidelines.

If a person wants to add a decade to their life, theyre going to have to do more than see the doctor and take their blood pressure and cholesterol medicine, he says, clarifying that those things still matter.

Along with physical activity, getting good sleep and nutrition, doing more may mean taking risks, something that he and others pursuing longevity and health span are willing to do to varying degrees.

We need to do more than the bare minimum, but do we need to be perfect? Getty

Harvard-based Australian biologist David Sinclair, a leading voice in anti-ageing research and lifespan extension, takes NAD+ booster supplement NMN, as well as resveratrol (which is reduced inflammation and risk of dementia) and metformin (which improves cardiometabolic health and increases lifespan ). Stanford neuroscientist Andrew Huberman, whose popular podcast explores longevity and health optimisation, also takes NMN (which theoretically boosts energy production and supports cellular repair, but comes with ), while podcaster Joe Rogan injects testosterone and , which advocates believe can boost growth hormone.

Yet there is a lack of good evidence in humans for most of these approaches. There are dosing and the interactions between different drugs.

Attia, who takes the medicine rapamycin, which , thinks about risk through the lens of investment. You could do nothing with your money and take no risk, or you could be sitting in Las Vegas gambling taking enormous risks, with enormous potential reward. There is, of course, a spectrum in between.

I think where you want to be on the spectrum is where you have the highest expected return, not the highest potential return. And I think the same is true in health, although its more difficult to quantify, Attia says.

That means considering the risk versus the expected return. He asks his patients whether they understand how a drug or supplement works; do they have a nutritional deficit or believe that super normal levels offer some benefit; is there a biomarker to track if its working; is there robust human data and if not, is there data across different species that demonstrates safety and efficacy. Finally, is it prescription-based or is it completely unregulated?

Dr Rosilene Ribeiro, a postdoctoral research fellow at the University of Sydneys Charles Perkins Centre, is more risk-averse than Attia. I would not recommend taking medication that has not been thoroughly tested and approved for human consumption, she says, adding that some of these drugs may and can interact with our diet in unknown ways.

Rapamycin has also been shown to affect immune function and cause adverse effects such as anaemia, leukopenia [low white blood cell count], elevated blood pressure and cholesterol, she says.

And although we are unlikely to ever attain it (and who would want to if it makes our life miserable?), Ribeiro believes we should strive towards lifestyle perfection. While genetics and environmental factors also play a significant role in our health and lifespan, lifestyle is one of the only factors we can generally control, she says. I would recommend that [people] focus their efforts there rather than taking medications with unknown side effects.

When thinking about how we approach risk and perfection in our pursuit of living well for longer, Attia believes one final question is worth considering.

After years of constantly tinkering and experimenting with different approaches to maximise his longevity and thinking of it as an engineering problem to be solved, he had a realisation:

Longevity is meaningless if your life sucks. Or if your relationships suck. None of it matters if your wife hates you. None of it matters if you are a shitty father ... all these need to be addressed if your life is to be worth prolonging - because the most important ingredient in the longevity equation is the why. Why do we want to live longer? For what? For whom?

Make the most of your health, relationships, fitness and nutrition with our Live Well newsletter. every Monday.

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How perfect do we have to be to age well? - Sydney Morning Herald

New Delhi,UPDATED: Mar 18, 2023 15:53 IST

Dr David Sinclair speaking at the India Today Conclave 2023 in Delhi. (Photo: India Today)

By India Today Science Desk: There is a backup of youth in our cells that we have recently learned about that can be made to work, Dr David Sinclair, Professor in the Department of Genetics at Harvard Medical School said. He added that the technology to reverse aging and trigger bio switches is developing faster than we expected.

"The science of aging and reversal has come a long way. It was considered crazy 20 years ago, but today we understand what drives aging and there is a backup of youth in our cells that we have recently learned that can be made to work. Technology is developing faster," Dr Sinclair added.

David Sinclair was speaking at the India Today Conclave 2023 in Delhi. He discussed the science of age and disease reversal as more and more research pours into understanding the process of aging. The 53-year-old genetics professor, who is also an anti-aging researcher, was recently in the news as he claimed his biological age is 10 years younger.

"What we discovered is that there are genes that control how long we live. Some people are born with the best version of those genes who tend to live for 100 years and what we have discovered is how we live our lives, move and consume, sleep, and how relaxed we are modifies another type of system known as epigenomes," Dr. Sinclair said.

Known for his work on understanding why we age and how to slow its effects, Dr. Sinclair said that the good news is that aging is easier to slow and reverse than we thought. The bad news is that the process gives our bodies a shock.

Speaking about the diet he takes to slow the process, the genetics professor said that there is a set of genes that get turned on when there is not enough energy, like low sugar and protein, and they defend the body against the damage that causes the aging process.

"I skip meals at times, but my goal is to not eat a large meal until dinner and then have a healthy vegan meal and little alcohol. I switched completely to planets and my body has responded well, my skin looks better, my memory is better. The three-meal system plus snacks is aging us faster than we need to," Dr. Sinclair said.

Talking about plant-based meals that he switched from meat and alcohol to slow his aging process, Dr. Sinclair said that "The proteins that are in plants have a ratio of amino acids that stimulate longevity genes, and if you eat meat every meal the body does not fight the way plants help it do."

Follow India Today Conclave 2023 Day 2 Live Updates

Edited By:

Sibu Kumar Tripathi

Published On:

Mar 18, 2023

Continue reading here:
There is a backup of our youth in cells that can be reversed: David ...

Its been 13 years in the making, but Dr. David Sinclair and his colleagues have finally answered the question of what drives aging. In a study published Jan. 12 in Cell, Sinclair, a professor of genetics and co-director of the Paul F. Glenn Center for Biology of Aging Research at Harvard Medical School, describes a groundbreaking aging clock that can speed up or reverse the aging of cells.

Scientists studying aging have debated what drives the process of senescence in cellsand primarily focused on mutations in DNA that can, over time, mess up a cells normal operations and trigger the process of cell death. But that theory wasnt supported by the fact that older peoples cells often were not riddled with mutations, and that animals or people harboring a higher burden of mutated cells dont seem to age prematurely.

Sinclair therefore focused on another part of the genome, called the epigenome. Since all cells have the same DNA blueprint, the epigenome is what makes skin cells turn into skin cells and brain cells into brain cells. It does this by providing different instructions to different cells for which genes to turn on, and which to keep silent. Epigenetics is similar to the instructions dressmakers rely on from patterns to create shirts, pants, or jackets. The starting fabric is the same, but the pattern determines what shape and function the final article of clothing takes. With cells, the epigenetic instructions lead to cells with different physical structures and functions in a process called differentiation.

In the Cell paper, Sinclair and his team report that not only can they age mice on an accelerated timeline, but they can also reverse the effects of that aging and restore some of the biological signs of youthfulness to the animals. That reversibility makes a strong case for the fact that the main drivers of aging arent mutations to the DNA, but miscues in the epigenetic instructions that somehow go awry. Sinclair has long proposed that aging is the result of losing critical instructions that cells need to continue functioning, in what he calls the Information Theory of Aging. Underlying aging is information that is lost in cells, not just the accumulation of damage, he says. Thats a paradigm shift in how to think about aging.

His latest results seem to support that theory. Its similar to the way software programs operate off hardware, but sometimes become corrupt and need a reboot, says Sinclair. If the cause of aging was because a cell became full of mutations, then age reversal would not be possible, he says. But by showing that we can reverse the aging process, that shows that the system is intact, that there is a backup copy and the software needs to be rebooted.

In the mice, he and his team developed a way to reboot cells to restart the backup copy of epigenetic instructions, essentially erasing the corrupted signals that put the cells on the path toward aging. They mimicked the effects of aging on the epigenome by introducing breaks in the DNA of young mice. (Outside of the lab, epigenetic changes can be driven by a number of things, including smoking, exposure to pollution and chemicals.) Once aged in this way, within a matter of weeks Sinclair saw that the mice began to show signs of older ageincluding grey fur, lower body weight despite unaltered diet, reduced activity, and increased frailty.

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The rebooting came in the form of a gene therapy involving three genes that instruct cells to reprogram themselvesin the case of the mice, the instructions guided the cells to restart the epigenetic changes that defined their identity as, for example, kidney and skin cells, two cell types that are prone to the effects of aging. These genes came from the suite of so-called Yamanaka stem cells factorsa set of four genes that Nobel scientist Shinya Yamanaka in 2006 discovered can turn back the clock on adult cells to their embryonic, stem cell state so they can start their development, or differentiation process, all over again. Sinclair didnt want to completely erase the cells epigenetic history, just reboot it enough to reset the epigenetic instructions. Using three of the four factors turned back the clock about 57%, enough to make the mice youthful again.

Were not making stem cells, but turning back the clock so they can regain their identity, says Sinclair. Ive been really surprised by how universally it works. We havent found a cell type yet that we cant age forward and backward.

Rejuvenating cells in mice is one thing, but will the process work in humans? Thats Sinclairs next step, and his team is already testing the system in non-human primates. The researchers are attaching a biological switch that would allow them to turn the clock on and off by tying the activation of the reprogramming genes to an antibiotic, doxycycline. Giving the animals doxycycline would start reversing the clock, and stopping the drug would halt the process. Sinclair is currently lab-testing the system with human neurons, skin, and fibroblast cells, which contribute to connective tissue.

In 2020, Sinclair reported that in mice, the process restored vision in older animals; the current results show that the system can apply to not just one tissue or organ, but the entire animal. He anticipates eye diseases will be the first condition used to test this aging reversal in people, since the gene therapy can be injected directly into the eye area.

We think of the processes behind aging, and diseases related to aging, as irreversible, says Sinclair. In the case of the eye, there is the misconception that you need to regrow new nerves. But in some cases the existing cells are just not functioning, so if you reboot them, they are fine. Its a new way to think about medicine.

That could mean that a host of diseasesincluding chronic conditions such as heart disease and even neurodegenerative disorders like Alzheimerscould be treated in large part by reversing the aging process that leads to them. Even before that happens, the process could be an important new tool for researchers studying these diseases. In most cases, scientists rely on young animals or tissues to model diseases of aging, which doesnt always faithfully reproduce the condition of aging. The new system makes the mice very old rapidly, so we can, for example, make human brain tissue the equivalent of what you would find in a 70 year old and use those in the mouse model to study Alzheimers disease that way, Sinclair says.

Beyond that, the implications of being able to age and rejuvenate tissues, organs, or even entire animals or people are mind-bending. Sinclair has rejuvenated the eye nerves multiple times, which raises the more existential question for bioethicists and society of considering what it would mean to continually rewind the clock on aging.

This study is just the first step in redefining what it means to age, and Sinclair is the first to acknowledge that it raises more questions than answers. We dont understand how rejuvenation really works, but we know it works, he says. We can use it to rejuvenate parts of the body and hopefully make medicines that will be revolutionary. Now, when I see an older person, I dont look at them as old, I just look at them as someone whose system needs to be rebooted. Its no longer a question of if rejuvenation is possible, but a question of when.

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Write to Andrew D. Johnson at andrew.johnson@time.com.

Read more from the original source:
Scientist Discovers Aging Clock to Speed and Reverse Aging | Time

Len Artick: We kept hearing that the Bulls are better than their record.At their best, they certainly are, but how about those other nights?You measure a team by consistency; not peak performance.People say, If they could do that every gameI say that if they could they would! If the Bulls truly are better than their record, there are only two questions: (1) Do the pieces fit? and (2) Does coach use them well?

Sam: Or you are what your record says you are? I dont believe they were, which is why I believe some substantial change is necessary. I agree with Karniovas not the blow it up kind. There seem to me enough there still to be a good core. But I do believe management and the coach has to get on the same page about the way the coach wants to play. If its more in transition, then they need some rebounding size. And if they want to stay more in the half court with someone like DeRozan, then definitely more shooting. I've suggested previously about maybe running more offense through Vuevi that could allow Coby White to be a point guard in the Denver model. But if not, some who is a more natural facilitator. Because after a year and a half out and with little likelihood Lonzo Ball will at least play next season or if he were to at any similar level, its difficult to make a case this group is better than a play-in candidate team. The appealing part as put on display in these playoffs is the Bulls with a few changes really may not be that far away given the incredible parity as play-in teams like Miami and the Lakers play for a chance to actually win the championship.

Brian Tucker: Whats your take on Ayton?Obviously talented but is he worth it to have on your team?Is he really a problem child on that Suns team, or is it a case of a young talent establishing ones game in the presence of stars being a tough challenge. I feel like he could be the scapegoat again and could be available.I wonder if theyd think a professional veteran like Vooch is a missing piece for their veteran roster, which would make for a sign-and-trade opportunity. I havent watched Ayton enough to know if that would be a good move for us, or if wed be better off keeping Vooch or looking elsewhere for a frontcourt refresh.

Sam: It does seem like its the end there for him and sitting out Game 6. He will be the scapegoat, and already has been among the fans in Phoenix. Remember, he got benched at the end of their also blowout closing game loss to Dallas last season and then the Suns only matched his free agency offer from the Pacers. Myles Turner deal? Then Ayton came to camp and said he never spoke with the coach about the benching. He hasnt produced in the playoffs, but they rarely run much for him with Booker and Durant dominating everything with Chris Paul out. By the way, its obvious you cant count on Paul by playoff time with injuries. They can save $45 million on his $60 million/two years if they release him next month. Will they? I was doing some lobbying for Ayton before the trade deadline when it looked like you maybe could get him in a package that included Mikal Bridges, Cam Johnson and Jae Crowder and maybe a pick. I thought if you packaged up DeRozan and Vuevi with some veterans like maybe Alex Caruso you could quickly remake your team and the Suns would be in better position for the short term to get the first title in franchise history. But they obviously were holding out for Durant. I cant blame them for that. But now they dont have much but Aytons $32 million salary. He has potential, but he alone would be too much risk, it seems to me. Id try to retain Vuevi and build more offense through him.

Luis Rodriguez: I would like to know what your opinion is in regards to signing Nikola, I believe a combination of Brook Lopez and Kyle Kuzma or Jakob Poetl and Christian Wood or any combination of the four is a betterfit for me. This would address two positions improve shooting rebounding and defense overall, without breaking the bank.

Sam: Unless the Bulls were to release Vuevi and trade DeRozan into cap room (basically giving him away for nothing or draft picks) they would not be far enough under the salary cap to acquire top free agents. Plus, it seems like Lopez, Kuzma and Poeltl are committed to resigning with their teams. I believe the Bulls are at the early stages of their development for the 23-24 season, which starts with the lottery next Tuesday. If the Bulls happen to get a top-four pick and No. 1, which surely will be Victor Wembanyama, that would likely set a new direction. Which wouldnt mean going all into the draft and trading away veterans. But more so adding a young player to the current core without too many major changes. I believe Karniovas when he said at this point he is mostly committed to the players he has. But as we saw in the summer of 2021 when he added DeRozan, Ball and Alex Caruso, he seems like the kind of executive who is flexible and willing to quickly recalibrate. I expect that to be the agenda as the trading season and free agency unfolds and players become available. You never know what is going on within a team, and rival executives dont know, either, until they get a call asking if theyd be interested. I expect changes with the Bulls, but I cannot even guess at this time what they may be.

Ed Zelnis: I find myself wondering where we'd be if the Bulls had stuck by their draft picks through thick and thin, and also had not made the bad coaching hires they did. If the current Bulls starting five consisted of Wendell Carter Jr., Lauri Markkanen, Jimmy Butler, Derrick Rose, and Coby White, with a bench of Bobby Portis, Taj Gibson, P-Will, Ayo, and maybe Dalen Terry or Doug McDermott, coached by either Billy Donovan or Tom Thibodeau, do you think such a team could still be playing in May? When I look over that list, it's hard to find fault with the front office in the draft department, but it's a scathing indictment of their coaching and player development.

Sam: There's no way to do that with injuries, contract issues (short contracts and a salary cap) and players upset with limited opportunity who want to move on. Remember, Jimmy is with his third team since the Bulls. Derrick, of course, was virtually out of the league at one point with so many injuries. Wendell and Lauri were pretty anxious to find new homes (and the community seemed to agree), and Thibs wanted his own team so he could be his own GM. That also didnt work out too well. Thats why two of the greatest societal evils of recent memory are social media and fantasy sports.

Rui Dias: What's your take on Joki and the fact that he wasn't the MVP or even in the All-NBA First Team? For a guy who average 24.5PTS , 11.8REB, 9.8AST per game. Shot 63% from the field including 38% from three-point range... was he robbed? Rules next season would exclude him from awards since he didn'tplay 70 games?

Sam: I would have voted for Embiid if only for when theres a tie at least give it to the guy who hasnt won before. I think Joki deserved it more this season than last when his team finished sixth. No matter how good you are, you shouldnt win MVP with a team that cant get one round of home court advantage no matter whos missing. You dont need MVPs to finish sixth. Embiid should have won last year. So maybe the makeup call, which Im fine with. But Embiid did average 33 points per game, the most for a center other than Wilt or Kareem (Bob McAdoo wasnt really a center; I think Gar Heard was defending a lot of the big scorers). And the 76ers had another winning season, which also is justification. If Embiiid is the MVP, then he has to be first team. Joki was second team, so thats correct. Both would have qualified since the NBA is changing the requirement to 65 games, which both barely made. Id rather see it at 70, but then the NBA wouldnt have many awards to give out.

John Leichenko: Is Embiid what Shaq should have been if he had developed his game? Ive never known what Shaqs claim as the most dominant player of all time means. He didnt dominate like Wilt. Or Michael. He didnt have much big center competition most of his career either. If there is any super hero that Shaq most resembles its the Hulk.

Sam: Lets not get too carried away since Embiid isnt quite Shaq yet. Sure, Embiid is more skilled with basketball requisites like shooting and ball handling. Which makes Shaq that much more impressive to have accomplished as much as he did. Imagine if he could shoot. So yes, Hulk-like, there never has been as physically an imposing a player in the NBA. And few ever got fouled more without going to the free throw line since it was so difficult to hurt Shaq or for him to even notice a 225-pound man was hitting him that the officials wouldnt call fouls. But Shaq was light on his feet and skilled enough around the basket to make basketball plays. Perhaps the league was fortunate that Shaq didnt really care about basketball that much. He was great fun to be around, generally the most popular player on the team who was glad to dress up as Santa and loved to entertain kids. It was the genesis of the issues between he and Kobe. Kobe was all about basketball and was offended Shaq not only was never in shape to start the season, but often took months to even try to get in shape. And then hed be the Finals MVP every time and dominate the playoffs. Its also why his decline was so abrupt when he went to the Suns, Cavs, Heat, etc. Shaq had a more wonderful attitude for life than the legends of the game like Michael, Kobe, Russell, Kareem, West who were so much more dedicated. Youd rather have spent time with Shaq more than any of them. Perhaps thats good for the NBA and competition. Because if Shaq really did care and had developed a game its difficult to contemplate what he could have accomplished.

Michael Wise: Who is the Bulls rep at the lottery Tuesday?

Sam: Its supposed to be Dalen Terry. Id have asked Steve Schanwald if I were the Bulls. The then marketing director who basically created the entertainment atmosphere that the Bulls are known for was the representative when the Bulls with a 1.7% chance moved up from ninth to No. 1 and selected Derrick Rose. No one talks about it much these days, but it wasnt the slam dunk to take Rose. There was not only among some Bulls staff but in the community some sentiment for Michael Beasley because the Bulls needed shooting (see, thats not new) and Beasley was being viewed as the next Kevin Durant. Basically until he got caught hiding women and drugs at the rookie orientation camp. The Bulls this year come into the Tuesday lottery at No. 11 with a 1.8% chance for No. 1. Rose became the star of that draft as the youngest ever MVP. But with his injuries, the players who have endured from that draft are No. 4 Russell Westbrook, No. 5 Kevin Love, No. 7 Eric Gordon and No. 10 Brook Lopez. Among others more than worth their spots were Robin Lopez at No. 15, JaVale McGee at No. 18, Serge Ibaka at No. 24, Nicholas Batum No. 25, George Hill No. 26 (so much for those mock drafts) and Goran Dragi No. 45. The big busts were in the top 10, Beasley at No. 2, OJ Mayo at No. 3 and Joe Alexander at No. 8. No. 9 where the Bulls were to pick was DJ Augustin.

Mike Sutera:I know you wouldn't want to trade him East, but I'd give DeMar to the Knicks. They have some tempting pieces. For Grimes, Fournier, and a 2023 first?

Sam: I think thats the kind of deal youd want to look at if they were moving DeRozan because hes basically just a one-year rental now at 34 with no guarantee hell resign. I can see hed make some sense for the Knicks as they need shooting and Thibs doesnt care for Fournier. And when Thibs is down on you, you are out. Fourier just has one more year left with a team option after that, and I think he's close with Vuevi. So maybe a revival.And he is a career 38% on threes with several seasons at 40 or more. Grimes also can make some shots, though they don't run much for him. Maybe you can get the Knicks to throw in Toppin, who Thibs also doesnt seem to like. Maybe flip Derrick Jones Jr. Plus, the Bulls want to get into this draft if they cant get a top four pick next week in the draft lottery. Id have to look at that because the Bulls really need to get bigger and get Patrick Williams at that starting wing position.

David Sinclair: Something that does not seem to be talked about after acquiring Pat Beverley and winning some games was that DeRozan had been moved to the 4 spot. A position he had played a lot in SA. Is there any positives of playing him more at the big forward spot long term?

Sam: No. I can expand on that. No way. I get it was a gimmicky kind of thing that had some success late in the season with the style Billy Donovan wanted to use in playing faster with more disruption on defense. But the Bulls shouldnt be fooled that its sustainable. You can see in these playoffs how much rebounding turns games, and you just cant keep putting those undersized guys out there at most every position. Not only for the lack of rebounding, but it also makes them more vulnerable to injury. The Bulls have sized down enough already since DeRozan really is a shooting guard. But it worked well enough with a big point guard in Lonzo Ball. Not a six foot Beverley. You maybe noticed in the play-in it took an historic Zach LaVine game to even get the Bulls past the first one, and then Miami just wore them down at the end.

Pete Ferro: Most of us seem to agree that theBulls need point guard help and better shooting but we don't have the budget to make this happen.Seems to me that giving Carlik Jones more of a run would makesense, at the very least as a back-up to say Coby.What am I missing?

Sam: There seems to be a stigma with being in the G League with some guys. I like Jones and believed he would have helped the Bulls because hes an actual point guard who can run a team and is a good shooter. But teams become beholden to the players they have invested in, so he wasnt going to get a chance ahead of Dosunmu and Dalen Terry. And then they brought in Patrick Beverley. A lot of life is opportunity, and if you dont get one no one really knows. His size probably is an issue with the team because he is listed at 6-foot, which usually means less. The Bulls seem determined like in the 2021 summer to prioritize a point guard, so he probably doesnt get a chance. But I wouldnt be opposed to seeing him. You know those Radford guys tend to be more than the experts believe they can be.

Ian Osorio: From what I have read Memphis isn't going to sign Dillon Brooks and I was wondering if the Bulls should get him now that he was announced as part of All NBA defensive second team. A potential lineup of Beverly, Zach, Demar, Brooks, VoochWith a second unit of Ayo, Coby, Caruso, PWill, and DrummondI don't know how to play it with DJJ and Javonte

Sam: Still kind of small since Brooks is about 6-foot-6. I know you can get away with smaller forwards in this NBA, but more like Draymond Green. And you saw Boston responded better going with Horford and Williams in Game 6. Little guards are cute. But if they are not Steph Curry, get some size.

Brodie Larsh: Assuming the Bulls don't get a draft pick, it seems like plan is to resign Vooch and Coby, and trade DeRozan for a PF. Have you heard a better trade than DeRozan to the Hawks for John Collins and Saddiq Bey? A sign and trade Jerami Grant for DeRozan may make sense as well with his connection to Donovan in OKC.

Sam: It might work for the Bulls since Bey was a nice addition, but I dont see how it makes much sense for Atlanta since they have the two point guards and DeAndre Hunter and want to work in AJ Griffin. They have wanted to move Collins, who doesnt ever seem to do much. But I might take a shot. Grant is a free agent looking for a big deal and really a wing player. Already with five teams, Id be cautious about a big deal for him. Ive mentioned the Lakers for DeMar since DeMar has expressed interest in playing there back home. But with two players (LeBron and Davis) making a combined $95 million the Lakers dont have much to offer. By the way, theres no Bulls plan to trade DeRozan for a power forward. Thats mostly fan and media speculation for now.

Mack Worth: Disney Rematch? Is this the NBAs worry? If 7th and 8th seed (Heat and Lakers) meet who will ever care about the regular season? Just more guys will coast and sit out and just be happy with getting 7-10 range.

Sam: Parity is welcome and makes for an exciting playoffs, which this has been. And should give more fan bases hope. You know, if those guys can get to the FinalsBut it strikes me as an existential problem for the NBA. I know theyre going to the 65 games thing for the awards. But those award bonuses are not much compared to their salaries. Some guys, like the Bulls three main guys, like to play and will play, so good for them. But you see, for example, with Miami Kyle Lowry obviously took the season off since all of a sudden hes playing 30 minutes every game at a high level. And, after all, if youre not an MVP candidate why worry about getting those 65 games to qualify? You know the league has to be rooting for Denver, which no one would ever say. But they were a rare top team to take at least most of the regular season seriously. You know Thibodeau teams will, but too many wont. Now just having to beat out five teams to get into the post season is an awful low bar. And it may actually work backward for the NBA with its new midseason tournament. I can see guys sitting out October and November and then playing since that's where they can make extra money in the tournament. The NBA should return to its long ago absence rules that if you want to miss a game you basically need a note from a league doctor. And if you dont get one you can lose pay for that game.

Art Alenik: Do you think think the salary cap has worked the way it was supposed to?Or even close?It probably does help with parity, so the richest teams cannot simply outbid the others and stack themselves with stars.But wasnt it also meant to curb the inflationary spiral of player salaries?It sure hasnt done that.We see now teams spending $20-40MM for a few stars and scrounging to fill out the roster without hitting the cap, or at least the luxury tax, with rookies or young players who havent established themselves yet.Its harder and harder to build a good balanced team without some luck.The owners dont care because their profits (and franchise values) keep increasing too.They just jack up the prices.The only real losers are the average fans who can no longer afford to attend a bunch of games.

Sam: Ive debated often about the owners not caring; look, the NBA has some owners who make a spectacle of themselves at games that I doubt is for the appearance fees. No one acts like that who doesnt care. The spike in franchise values was a surprise to everyone. So it became a great investment; but so was Microsoft and Nike. Theres hardly anyone who got into the NBA who couldnt have made more money in other ventures. I know what fans often believe out of frustration. But when your day is filled with questions (and criticisms) about how your team did, Im pretty sure you care more about its success than most anyone else. The salary cap, meanwhile, never was supposed to equalize salaries or create a ceiling. The players in negotiations were opposed to that. Its more what the owners preferred. But like in baseball when A-Rod one time wanted to take a lower deal to go to the Red Sox, the union overturned it on the precedent that it could suppress salaries. The player unions in most sports operate on the assumption of the rising tide floats all boats. Though with a salary cap and luxury tax penalties, the true result is creating the increasing income gaps that are familiar in society as a whole. The unions, though they'll deny it, generally operate for the benefit of the highest salaries players whose agents tend to have the largest voices with the unions. Isiah Thomas was a polarizing figure. But many of those issues surfaced when he was players union chief and tried to fund more for the so called middle class. Thats a lot what led to his estrangement with some of the games top stars.

Mitch Tobin: I've been watching the NBA for decades, and perhaps its just my imagination, but it seems as if all the complaining to the officials on virtually every play has become an annoying plague. Has it always been this way, or has it gotten worse? Whats particularly annoying is when players lag play going the other way while they gesticulate to the officials, as if that will make a difference.Props to Steph Curry, though. Sacramento was playing him pretty physically, hand checking him outside the three-point line on almost every play, and he rarely complained. I thought that hand checking was not supposed to be allowed anymore.

Sam: Let me assure you players always have complained to officials, and fans always have found conspiracies in the way their teams were treated by the officials. Though its more modern history, the Phil Jackson/Pat Riley referee debates were legendary game to game stuff in the 90s playoffs. Phil famously called hall of fame referee Dick Bavetta Knick Bavetta because Bavetta was from Brooklyn and grew up a Knicks fan. The league was not amused. But like with a lot of parent disciple or lack of with the trophies for all trend the NBA hasnt allowed its officials to, say, sternly remind Luka Doncic and LeBron they were not fouled on every single play of the season. A bit of the difference was years ago you had two officials per game who were stronger and somewhat more empowered who took some complaints and then began ejecting guys no matter their reputations. Players adjust quickly. They did then to some extent. Its really on the league to legislate, and for now it doesnt care to.

Larry Jurkens:It sure seems the officials are allowing significantly more physical play... and why do they quite often seem to wait to see if a shot went in before they call a foul? Shouldn't a foul be a foul no matter what?

Sam: Because if they called everything that the rule book states is a foul remember its not supposed to be a contact sport then the games would last about eight hours with 500 free throws. I believe NBA officials despite the flaws are the best in sports. Baseball is pretty easy, though we see plenty of strikes called outside those boxes. I assume before too long AI takes care of all that officiating; though I would enjoy it if it were Allen Iverson. Football is ridiculous. The announcers who generally are former players still cant figure out what is a catch. And have you ever seen a play without at least seven guys holding? I like what the NBA officials do because they come to understand the game and want to continue the flow. So theyll sometimes let fouls go if they see the guy is scoring. If the ball doesnt go in, theyll call something to equalize the play. Im also an advocate of the makeup call that used to be more common. The great officials want the players to decide the game; so when they make a mistake theyd often try to equalize it on the next play and then basically the statement to the players that the rest is on you. The playoffs are a bit different, but the regular season skews the game because so many of the home team announcers are whining about fouls that should have been called for their team and forget the fouls and flops of their team. If you watch just one team broadcast you tend to get caught up in what seems like bias. Id say a greater problem than the officials missing calls is all the fakery going on among the players trying to trick the officials into making calls. How do you justify complaining about what an official misses if so many players are basically trying to cheat the game with their face flag operations? Sorry, I don't have much sympathy.

Steve Walter: I've seen this Bulls team have crazy turnovers when pressed. A ball handler as a backup/replacement for Ball makes sense. It appears the organization doesn't see Carlik in this role. Shooting a respectable % from deep must be a priority for any new acquisitions. Assuming Vooch stays, a defensive minded, quick rotating four is critical to avoid the constant layup line we saw in so many Bulls losses. It would be so cool to see Derrick Jones Jr, Pat Williams, and Javonte playing the small wing against players their own size. Bobby Weiss, Wilbur Holland, and Mickey Johnson would make this team Champs!All the best from Fantasy Island.

Sam: Wilber is deceased and Bobby and Mickey dont quite move like they once did, so its probably not a plan for now.

Got a question for Sam?Submit your question to Sam atasksam@bulls.com

The contents of this page have not been reviewed or endorsed by the Chicago Bulls. All opinions expressed by Sam Smith are solely his own and do not reflect the opinions of the Chicago Bulls or its Basketball Operations staff, parent company, partners, or sponsors. His sources are not known to the Bulls and he has no special access to information beyond the access and privileges that go along with being an NBA accredited member of the media.

Excerpt from:
Ask Sam Mailbag: Looking at the fit of the Bulls roster - NBA.com

Whats the secret to looking and feeling younger? For some, its expensive surgeries. For others, its a change in health and wellness habits. But what does science say?

David Sinclair, a 53-year-old genetics professor and anti-aging researcher who claims his biological age is 10 years younger, swears by four key habits:

While these habits can certainly contribute to a healthy lifestyle overall, experts disagree about their link to longevity. For example, research is mixed on whether intermittent fasting can slow the aging process. But Sinclair, who is also the cofounder of Tally Health, a membership-based longevity platform that includes TallyAge testing, an at-home test to determine your biological age, says his habits have dramatically altered his life span.

My calculated biological age has been going down for the past decade or more to a point where Im predicted to live at least a decade longer than I would have if I hadnt done anything, Sinclair said in a recent interview with Insider. So its never too late.

In addition to a plant-based diet and cutting back on alcohol, Sinclair shared that he drinks one to two matcha teas per day and takes supplements that contain resveratrol, an anti-inflammatory compound most commonly found in red wine. But the jury is out on whether people can reap the same benefits in a pill form.

As soon as I see resveratrol in anybodys supplement stack, they lose all credibility, University of Washington longevity researcher Matt Kaeberlein told Insider. Its been disproven over and over and over in the longevity field, at least.

Sinclair, however, maintains that these habits arent just about living longer, but making the most of healthy years.

Nobody wants to be sick for a decade or have cancer that drags on or be frail, he told Insider. What were really talking about is preventing those things, or squeezing them into the last bit of life.

Link:
Four habits to reduce your biological age | Fortune Well

In Episode 6 of the Lifespan podcast, Dr. David Sinclair and co-host Matthew LaPlante discuss cosmetic aging and how to improve skin, nails, and hair. They talk about why superficial aging occurs and how external signs of aging are often a reflection of biological age. The latest science behind various beautifying therapies is highlighted, including newer interventions like low-level laser therapy and platelet-rich plasma injections.

Thank you to our sponsors:

Athletic Greens - https://athleticgreens.com/sinclairLevels - https://levels.link/sinclairInsideTracker - https://insidetracker.com/sinclair

Our Patreon page: https://www.patreon.com/davidsinclair

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To stay up to date with David's work to democratize biological age testing and insights, visit tallyhealth.com.

Timestamps:

(00:00:00) Launching Episode Six: Combating Cosmetic Aging & Improving Skin, Nails & Hair

(00:02:54) Estrogen, Progesterone, and Menopause

(00:09:51) Thanking the Sponsors

(00:12:57) The Pinch Test, Epidermal Thinning, and Foot Ulcers

(00:18:29) Skin and Biological Aging

(00:23:19) Cellular Senescence, Ultraviolet Light, and Skin Aging

(00:28:15) Collagen, Keratin, and Skin Health

(00:33:38) A Quick Aside about Nails

(00:34:45) Autophagy and Retinoids

(00:36:57) Resveratrol, NAD Boosters, and Hyaluronic Acid

(00:41:44) Botox, Skin Peels, and Microneedling

(00:43:28) No Duh Stuff: Sun Damage, Smoking, Alcohol, and Bad Food

(00:45:42) Hair Loss and Hair Graying

(00:49:45) Topical Treatments, Pills, and Dihydrotestosterone

(00:55:19) Frickin Laser Beams: Low-level Laser Therapy

(00:57:59) Platelet-rich Plasma (PRP) Injections

(01:00:11) Hair Aging, Stress, and Gray Hair Reversal

(01:06:11) Targeting Aging Upstream

(01:07:37) Todays Takeaways

(01:09:25) Subscription and Support Options

For the full show notes, including the peer-reviewed studies, visit the Lifespan podcast website.

Please note that Lifespan with Dr. David Sinclair is distinct from Dr. Sinclair's teaching and research roles at Harvard Medical School. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Lifespan with Dr. David Sinclair podcast, its employees, guests and affiliates assume no liability for the application of the information discussed.

Title Card Photo Credit: Mike Blabac

Special thanks to our research assistants, Adiv Johnson & Sarah Ryan.

More here:
Lifespan with Dr. David Sinclair on Apple Podcasts

David Sinclair and Anti-Aging Supplements

Dr. David Sinclair has revolutionized the way that people view aging. As a scientist and pioneer in genetics and longevity research, hes been listed by TIME as one of the 100 Most Influential People in the World, has received more than 35 awards and honors, and is currently working as a professor in the Department of Genetics and co-director of the Paul F. Glenn Center for the Biology of Aging at Harvard Medical School.

Sinclair is also the author of a New York Times bestseller, Lifespan: Why We Age And Why We Dont Have To, published in 2019. His book presents scientific research in a way that is understandable and its inspired people of all ages to strive for a longer, healthier life.

In his book, he talks about the history of longevity research, current developments and the future of the field. He shares his unique views on aging, which has people rethinking their own outlook on it.

He believes that aging is a disease, its treatable and that we can treat it within our lifetimes.

According to Sinclair, There is no biological law that says we must age.

Sinclairs work involves focusing on aging as the cause of most diseases, while figuring out how the process can be slowed down and reversed. He states that people have longevity genes, which are built-in defenses against aging.

David Sinclair, along with other prominent longevity experts, takes Metformin, which is a prescription medication commonly used by diabetics. Research shows great potential for other uses. In his recent podcast, Sinclair stated that people on Metformin with diabetes live longer than people without diabetes and not on it, and theyre also protected against diseases. But, for those who arent able to acquire a prescription, or would prefer a natural alternative, Berberine may be a better option. Berberine has studies to show that it may have similar effects. Its been shown to help lower blood sugar and improve cardiovascular health, among other potential benefits.

In his book Lifespan, David Sinclair mentions that he takes 1 gram of NMN. This is an obvious choice because recent research has been pointing towards the benefits of taking NAD+ precursors. NMN is the most stable and most reliable nicotinamide adenine dinucleotide (NAD+) precursor available in the market.

The reason that David Sinclair takes NMN is to improve the NAD+ levels in the body. When we age, the NAD+ available to our cells and tissues steadily declines. The latest research shows that by increasing the NAD+ levels available to our body, we can slow down or even reverse the process of aging.

NMN is found in nature, especially in fruits and vegetables like cucumbers, edamame, cabbage, broccoli, and avocados. However, the amount of NMN is too little for us to replenish the depleting NAD+ reserves of our bodies. Most of our NMN comes from vitamin B3 synthesis. Taking NMN supplements allows us to increase the amount of NMN available to our tissues, thus replenishing the lowering levels of NAD+ with age.

While our understanding of NMN and NAD+ is still evolving, research continues to confirm its role in NAD+ production. It is understood that NMN and NR (another NAD+ precursor) are involved in a cycle where NMN gets converted to NR which then goes into the cell to produce NAD+. Recently, a study has discovered an elusive NMN transporter that delivers NMN inside the cell. Thus, as we understand NMN better, we find it to be increasingly important in NAD+ production and anti-aging.

The second supplement mentioned by David Sinclair in his book Lifespan is Resveratrol. He says that he takes 1 gram of Resveratrol, along with NMN, in the morning (See Figure 3).

Resveratrol belongs to a group called polyphenols and is found in over 70 species of plants, including berries and red grapes. Research has found a lot of anti-aging benefits of Resveratrol including its anti-oxidant

properties , anti-inflammation activity, its role in weight loss and cardiovascular health, and its anti-cancer properties . Thus, there are a variety of reasons to consume Resveratrol supplements.

David Sinclair also takes the prescription drug metformin. The drug is mainly prescribed to individuals with type-2 diabetes. However, metformin has shown remarkable life-extending properties in mammals and many organisms. Diabetics who take metformin end up living longer than non-diabetes who do not take the drug. With so many benefits, it is obvious why David Sinclair decided to take the drug.

However, metformin does not come without its own set of issues. In the short term, metformin is associated with a range of side effects such as gastrointestinal discomfort and diarrhea. These symptoms decrease in a matter of a few weeks. However, metformin is also associated with higher uptake of Vitamin B12 in the longer run. Metformin is also believed to decrease the benefits of exercise. It also lowers endurance and negatively impacts muscle strength.

While David Sinclair stated that he takes metformin, many others are turning to Berberine as a natural non-prescription alternative. Berberine has the ability to mimic the anti-diabetic properties of metformin while perhaps even outperforming it in enhancing longevity and stabilizing blood sugar.

Vitamin D is necessary for a number of functions, including activating many important genes. A vitamin D deficiency increases the risk of many conditions that speed up the process of aging such as type-2 diabetes, Alzheimers diseases, cardiovascular diseases, etc.

As for vitamin K, its benefits are numerous and spread across the body. It is good for mitochondrial and vascular health and also plays a part in improving skin appearance and it works synergistically with Vitamin D.

Sinclair recently said on Twitter that he has been taking Fisetin for over two years. He also cited a study by Yu-Fen Lin and the team, noticing that Fisetin reduces chronic stress in mice.

Fisetin is also credited with removing senescent cells from our bodies. A 2016 study noted the following as benefits of Fisetin: anti-inflammatory, anti-oxidant, anti-tumorigenic, anti-invasive, anti-angiogenic, anti-diabetic, neuroprotective, and cardioprotective effects in cell culture and animal models relevant to human diseases. Sinclair believes that Fisetin is important in fighting to age.

Quercetin is a flavonoid contained in many fruits and vegetables like grapes, apples, broccoli, and tomatoes. Quercetin has many antioxidant and anti-inflammatory properties but recently, David Sinclair has stated that he takes it daily as a senolytic.

Quercetin was recently shown to reduce senescent cells in adipose tissue. In another study, it was shown to have an even stronger effect when combined with the chemotherapy drug, Dasatinib. Other benefits of Quercetin include reduced swelling, destroying cancer cells, controlling blood sugar, and helping to prevent heart disease.

Coenzyme Q10 is a powerful antioxidant that may prevent certain diseases and signs of aging. Specifically, CoQ10 is involved in energy production and can prevent cellular damage associated with aging.

In studies, CoQ10 has been shown to prevent neurogenerative diseases like Parkinsons, Alzheimers, Huntingtons disease, progressive supranuclear palsy, and other forms of dementia. Coenzyme Q10 may help with certain cardiac diseases, including heart failure, atherosclerosis (fatty deposits in the arteries), and coronary artery disease (fatty deposits in the arteries supplying blood to your heart). Sinclair has added CoQ10 to his supplement stack and has mentioned its benefits in several podcasts.

Trimethylglycine (TMG) also referred to as betaine or betaine anhydrous is a compound that consists of glycine with three attached methyl groups. It is produced by the body and is found naturally in beetroot and other foods. TMG can also be found in supplements, sometimes used to enhance athletic performance and improve heart and liver health.

David Sinclair has stated that he takes Trimethylglycine as an insurance policy against the loss of too many methyl groups while taking NMN. When too much NMN is converted to nicotinamide, this excess NAM is excreted out the urine with a methyl group attached, potentially causing levels to run low. Methyl groups are important for synthesizing creatine for muscles and dopamine for the brain. Low levels can be responsible for muscle fatigue and/or depression.

Spermidine is a powerful anti-aging drug that has been shown in studies to extend lifespan in model organisms including yeast, nematodes, flies and mice and has the potential to extend lifespan in humans as well. It does so by inducing a process known as autophagy, the bodys way of cleaning out damaged cells, in order to regenerate newer, healthier ones.

This ability to recycle cells and clear out dead and dying debris is known to have great anti-aging benefits in recent studies, possibly delaying the aging process in humans. David Sinclair has mentioned that he has added this important supplement to his stack in recent podcasts.

Sinclair has mentioned on Twitter that he also takes a prescription drug known as Statin. He takes it for a cardiovascular condition that is common in his family.

More here:
David Sinclairs Anti-Aging Supplement List 2022 - Food Security

Dr. David Sinclair is a world-renowned longevity scientist best known for his research on resveratrol and the sirtuin genes of yeast. He has also been recognized by TIME magazine as one of the top 100 most influential people globally and is an Adjunct Professor of genetics at Harvard Medical School.

Besides supplementing with groundbreaking anti-aging drugs such as NMNand resveratrol, David follows a strict diet and exercise routine.

Dr. Sinclairs work on aging has profoundly impacted our understanding of how aging works and what it means to be old- and, more importantly, how we can live longer, healthier lives without radical life extension technologies. Here are sixteen Dr. Davids recommendations on diet and exercise from his book Lifespan: Why We Age and Why We Dont Have To.

Dr. David Sinclair is a firm believer in restricting caloric intake to extend life expectancy. However, he doesnt fully subscribe to the belief that calorie restriction can dramatically prolong human longevity. Calorie restriction has been shown to work in every animal except humans, says Dr. Sinclair, who believes that reducing daily caloric intake by 30 percent should result in increased longevity.

Although Dr. Sinclair says there is no way of knowing for sure if 30 percent is the optimal caloric intake level, he also points out that there are now literally hundreds of experiments in animals showing lifespan extension by calorie restriction.

RELATED READING: Dr. David Sinclairs Supplement List for Longevity

Theres a lot of evidence that exercise extends lifespan. You can probably extend the life of mice by doing wheel running, but its not for another ten years-its maybe 5 percent longer.

Dr. Sinclair should know, he conducted many of the first studies showing the health benefits of caloric restriction in yeast and its effects on human cells growing in lab dishes; later, these experiments led to clinical trials in humans. In fact, Dr. Sinclair is a proponent of exercise and includes walking as part of his daily regimen. I limit calories greatly, but I do exercise every day, he says.

RELATED READING: Dr. Peter Attias Supplement List, Biohacking Toolkit, & Diet

We all have a certain percentage of fat in our body, and we also have some sugar thats stored in the liver. In human experiments, after fasting overnight, people get about half their energy from burning sugar and half from burning fat. So every day when youre fasting, says Dr. Sinclair, you use up part of your sugar and part of your fat. Every time you eat, you replenish the sugar, so its always half full-its about 50 percent full every day.

RELATED READING: Dr. David Sinclairs NMN & Resveratrol Protocol

David believes that constant snacking is not the best way to prolong life expectancy. Im big on intermittent fasting and restricting calories, and I think people should not snack-its much better to have your three meals a day, says Dr. Sinclair, who also advocates skipping breakfast. When you intermittent fast, you can reduce insulin levels by 40 percent, and that helps improve health in many different ways.

RELATED READING: Tim Ferrisss 3-Day Fasting Protocol

Dr. Sinclair believes that people should use natural supplements instead of prescription drugs because theyre less expensive and more effective. Many prescription drugs are toxic and dangerous, says Dr. Sinclair, who believes that supplements can also play an important role in preventing damage from free radicals and promoting health. Natural supplements can replace prescription drugs-theyre safer and more effective.

Dr. Sinclair is huge advocate for taking Nicotinamide Mononucleotide (NMN) and Resveratrol which made red wine famous for being known for extending your life in small amounts. David has his own supply in his lab that he takes, but fortunately you can pick up NMN and Resveratrol on the Renue By Science website. You can read up on David Sinclairs Supplement Regime here.

RELATED READING: Dr. Andrew Hubermans Time-Restricted Diet

Dr. Sinclair emphasizes that you cant take shortcuts when it comes to planning a diet and exercise regimen-the best way to prolong life expectancy is to eat st healthy balanced diet food, taking care not to overload your body with fructose or simple sugars. Every time you eat fruit, its like eating sugar because the fructose in the fruit turns into glucose very quickly, says Dr. Sinclair, who recommends eating green vegetables and blueberries every day to get the maximum levels of antioxidants in your diet.

Im a big proponent of the view that we seem to be getting more and more people focused on these high-tech anti-aging treatments, says Dr. Sinclair. He believes that vast sums of money spent on life extension research would be better used for other purposes. My biggest regret is that gerontologists have been focusing so much money on a very, very few approaches to anti-aging research, says Dr. Sinclair, who urges people to explore lifestyle choices that have been proven effective in prolonging life. Theres a lot of evidence that caloric restriction works and exercise works.

RELATED READING: Dr. Andrew Hubermans Sleep Cocktail

Dr. David Sinclair believes that exercise should be high-intensity so it can trigger The Epigenetic clock. I dont believe in exercise that is not strenuous, says Dr. Sinclair, who adds that people should try high-intensity interval training three times a week, working out at 85 percent of their maximum heart rate for about two minutes or until they are exhausted. You can get the benefits of exercise in three minutes a day just do sprinting to exhaustion, just push yourself as hard as you possibly can for about 3 minutes and then rest.

Dr. Sinclair believes that when exercising, you should also breathe deeply and rapidly to boost oxygen in the bloodstream and increase caloric burn, which will help activate the Epigenetic clock. Ive been a big proponent of breathing during exercise-breathing every 20 seconds, says Dr. Sinclair, who adds that he stays in good shape by running three miles every morning. Its really changed my life; I have more energy-its great.

RELATED READING: Dr. Andrew Hubermans Supplement List

Cold weather increases your immune system, says Dr. Sinclair, who recommends people get their hands on a cold thermometer and put it in their armpits when they wake up-the colder the reading in 10 minutes, the healthier you are. The less time you will spend with disease symptoms. Theres an evolutionary theory that the reason we like the heat is that it simulates our African origins, where everything was hot and tropical, says Dr. Sinclair. Cold is the future-we evolved as cold-weather animals.

Dr. Sinclair believes that your genetic make-up is not a predictor of your future health. The most important thing about beating aging is to know that the fate of your health is in your hands, says Dr. Sinclair, who believes people can significantly slow down the clock with healthy lifestyle choices. Weve gotten rid of the idea that its just genes against destiny-we know that we can change the genes, and we can change our destiny.

RELATED READING: Tim Ferriss Supplement Stack

Im absolutely against cigarettes, says Dr. Sinclair, who urges people to avoid smoking and all other tobacco products because they contain a potent toxin called formaldehyde, which is used in embalming fluid. People think that cigarettes are safe-cigarettes kill half a million Americans every year, says Dr. Sinclair, who believes the health consequences from smoking are so severe that many people have been driven to drug abuse.

Dr. Sinclair urges people to avoid alcohol as much as possible because of its link to cancer. Alcohol is a major carcinogen, says Dr. Sinclair, who believes that if you drink alcohol, you should limit yourself to one glass of wine per day. Every time people take a drink, they raise their risk of breast cancer and another cancers-its just not worth it, says Dr. Sinclair, who points out that there is strong evidence that alcohol can cause tumors in the mouth and throat.

RELATED READING: Dr. Rhonda Patricks Fish Oil Protocol & Brand

Dr. Sinclair recommends that people avoid heating food in plastic containers because it can cause toxic chemicals to leak into the food and lead to cancer and other disorders. Dont microwave in Styrofoam or plastic, says Dr. Sinclair, who urges people to stop using plastic containers when cooking and instead use glass, which doesnt contain harmful chemicals. Those plastic containers are a real danger-microwaving food in them for as few as five minutes can leach out those toxic compounds into your food.

Dr. Sinclair recommends that people who want to quit smoking should try natural nicotine replacement therapy instead of smoking, which actually increases craving. I think the best way to quit smoking is not to start, says Dr. Sinclair, who believes people should make an effort to stop smoking because cigarette smoke remains in the body for a long time after you finish your last cigarette and can cause cancer even if it has been years since you lit up. The sooner you quit smoking, the better off you are if you quit at age 20; your life expectancy is almost normal.

Dr. Sinclair believes people should make an effort to eat fruits and vegetables every day, either in a smoothie or salad. Youve got to get at least five servings of fruits and veggies every single day, says Dr. Sinclair, who believes that both fruits and vegetables reduce the risk of cancer and other diseases by eliminating free radicals from the body. If you want to live a long life, it all starts with those five servings.

Dr. David A. Sinclair is a famous author, professor, and scientist of international repute known for his research on aging and its control in the body with natural ingredients, which the scientific community has widely recognized. You can pick up his book Lifespan: Why We Age and Why We Dont Have To on Amazon.

Though Dr. David A. Sinclair has received numerous awards, he still works hard towards achieving more scientific breakthroughs and gives lectures to promote awareness about nutrition and dietetics.

He instills a sense of motivation and positivity in the people who seek his advice and help them improve their health and lead a healthier life without getting exposed to harmful chemicals which can cause damage to our body over time.

Go here to see the original:
Dr. David Sinclairs Diet & Exercise Protocol - Brainflow

Home sharing is growing in popularity among older adults, as new research reveals, one in three people over 55 would consider having a housemate in later life to save money and avoid living alone.

Proving best friends are forever, almost a third (31 percent) of the 2,000 over 55-year-olds surveyed said they would be open to moving in with a friend in retirement, with more than one in six (18 percent) admitting that theyd rather live with friends than family. An adventurous four percent said theyd consider renting with a complete stranger.

According to property management service provider, FirstPort, who commissioned the study, the retirement roomie trend will only continue to grow as people look to save money.

The company has already seen a 27 percent increase in enquiries for independent-living retirement developments in the last year, with many requesting to move to the same development as their friends some even as next-door neighbours.

According to the research, 12 percent of the Baby Boomers questioned said the pandemic had changed their attitude towards communal living. However, for 63 percent of surveyors, financial fears remained their biggest concern.

Other reasons cited for co-living were company (40 percent), safety (25 percent) and sharing household chores and admin (15 percent).

Suggesting its not all doom and gloom, one in five (20 percent) said theyd live with others to have fun and 17 percent would do so to enjoy shared hobbies and interests together.

READ MORE:Best trick to successfully clean grout - costs pennies

When asked what they fear most about later life living, a solid 68 percent of people said losing their independence, closely followed by not having enough money at 48 percent. One in six (15 percent) were concerned about losing touch with family and friends, whereas 38 percent of people said being alone was their biggest fear.

A review of social media and retirement forums online found that friends and making friends were the most frequently used words in conversations about later life.

David Sinclair, Chief Executive of the International Longevity Centre UK (ILC) says: "As we get older, we spend an increasing amount of time at home alone and watching television. In old age our network of friends and family is often smaller than it was. One in five of us doesnt have children and we are more likely than in the past to be divorced or separated.

Wed like to see more diverse options for housing for older people, and this includes living with friends, which shouldnt just be for younger people. House-sharing is a great way to build and strengthen relationships and enjoy the company of others, rather than just the characters on our TV screens.

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Gareth Cayford, Director Retirement at FirstPort says: The events of the last few years have had a seismic impact on peoples attitudes towards later life, leading many to completely rethink what they want in retirement, and who they want to spend it with.

We are seeing a growing number of enquiries for friends and families looking to live near each other or in the same development buildings, and we expect this to continue to rise in the future especially with increasing living costs.

"Its not just a prudent choice but one that demonstrates that independent retirement development living - with communal lounges and spaces to socialise with friends - is more important than ever.

Ceinwen Kerslake (85) and Gillian Morgan (77), have been friends for over 40 years and live next door to each other in communal development, Homegower House, Swansea.

Gillian says: After both losing our husbands, we each experienced the loneliness of being widows living in larger houses and wanted to downsize. I would come and visit Cei who moved into the development first, and eventually decided to buy a flat of my own right next door!

Living next door to each other has brought us closer together as friends, we now spend five days a week together, doing activities like eating out with friends and joining in the development activities.

Cei added: Living so close to each other gives us the peace of mind that we can rely on each other when needed, whether thats a medical emergency or just borrowing milk for a cup of tea.

We actually tend to share food and save money on our weekly shop! We never expected to live so close to each other in later life but the company we offer has brought us so much joy, we would encourage anyone in a similar situation to us to do the same.

See the original post:
Over 55s turn to house shares to save money and avoid loneliness - Express

Kris Jones came out on top with an incredibly quick time of 63 minutes and 46 seconds

Around 11,000 runners descended upon a gloriously sunny Trafford this morning (Sunday October 9) for the Manchester Half Marathon. Competitors and spectators alike were treated to perfect weather and gorgeous blue skies for the 13.1 mile run through the streets of Sale, Stretford, and for the first time ever, Manchester city centre.

Kris Jones, of Swansea Harriers, came out on top with an incredibly quick time of 63 minutes and 46 seconds. James Tilley (Nantwich) and Chorlton's own Tom Charles came second and third respectively.

James' dad Neil Tilley was bursting with pride as he spoke with the Manchester Evening News after watching his son get silver. He said: "I'm so proud. It's his first year of proper marathon running and that's the fastest I've ever seen him. He came 25th in the full marathon earlier this year but this is his best result in a major race over here."

Stockport Harriers runner Mollie Williams won in the women's category for a second year in a row, with an impressive time of 73 minutes and 29 seconds. David Sinclair took the wheelchair half marathon crown, finishing in 84 minutes and nine seconds.

Competitors' friends and family created a great atmosphere throughout, with many bringing signs and cheering their loved ones on, while Manchester music from the likes of Oasis, Courteeners and M People blasted out of the PA system speakers at the start and finish lines.

Plenty of runners donned fancy dress and ran for charities, with the highlight probably being The Justice League's Wonder Woman, The Flash and Batman, running alongside Avenger Captain America. Despite athletes trying to better their own personal records, a couple of competitors stopped to help a runner named Andy Matthews over the line, when it became clear that he was struggling.

A gallery of photos from the race can be found below:

Link:
Manchester Half Marathon 2022 in pictures as thousands race along sunny streets of Greater Manchester - Manchester Evening News

The new authorized biography of late Rolling Stones drummer Charlie Watts was launched at a special event on Friday night (16) at south Londons Sound Lounge venue.

Charlies Good Tonight: The Life, The Times and the Rolling Stones, by music writer, broadcaster, uDiscover Music contributor, and longtime Stones chronicler and interviewer Paul Sexton, has the approval of Watts family and is endorsed by the band themselves.

It features forewords by both Mick Jagger and Keith Richards and a prelude by former band manager and producer Andrew Loog Oldham, and was published in the UK on Thursday (15) by Mudlark/HarperCollins. US publication follows on October 11, after which it will be out in the Netherlands on October 24, Spain in November and numerous other countries next year.

The launch evening combined live performances with audio and video celebrating the life and work of one of the most admired musicians in the worlds of both rock and jazz. A core live band featured guitarist and Sound Lounge co-founder Keiron Marshall, bassist Terry Peaker, and drummer Nigel Appleton, with guest appearances by David Sinclair, leader of his own David Sinclair 4; rock singer Helen Hurd; Danny George Wilson, of UK Americana Award-winning bands Danny and the Champions of the World and Bennett Wilson Poole; and his frequent collaborator on guitar, Paul Lush.

The location of the venue, one block away from the pub in Sutton formerly called the Red Lion, where the Stones played many early gigs both before and after the arrival of Watts and Bill Wyman in the line-up, was reflected in the opening live tracks. Chuck Berrys Bye Bye Johnny, with lead vocals by Sinclair and also featured on the DS4s new Apropos Blues album, was on the Stones first, self-tjtled EP in January 1964; Slim Harpos Im A King Bee, with vocals by Marshall, was on the groups debut album three months later.

Later tracks performed on the night included another Berry composition, Let It Rock, again featuring Sinclair; Time Is On My Side and Mixed Emotions, both with Wilsons lead; Tumbling Dice, featuring Hurd, and a closing return to the Stones R&B roots with Ride Em On Down, the Eddie Taylor song covered by the band on their chart-topping 2016 album Blue & Lonesome.

Interspersed with the live performances were tracks from albums by the Stones and from Watts various jazz projects, selected videos, and excerpts from Sextons interviews with the band, whom he has been interviewing since the early 1990s. Guests at the event, featured in the book, included Watts tailor and shoemaker respectively, Dario and John Carnera, and Nettie Baker, daughter of Ginger, with whom Charlie had a lifelong friendship.

Listen to the best of the Rolling Stones onApple MusicandSpotify.

See original here:
Authorized Biography Of The Rolling Stones Charlie Watts Launched In London - uDiscover Music

In the second podcast based on his book LifeSpan, Dr. Sinclair talks about the science behind how fasting and eating certain foods promote longevity.

Highlights:

In the second podcast episode of Lifespan with Dr. David Sinclair, he and co-host Matthew LaPlante discuss how we can live longer by changing the way we eat. They guide listeners towards a path to longer living by examining how we can change our eating habits to live longer, all while explaining the relevant science.

If three words could sum up how to live longer by changing our eating habits, Dr. Sinclair would say, eat less often. This does not necessarily mean consuming fewer calories but packing in the calories within a shorter period. In fact, we need calories to avoid malnourishment and starvation.

Why eat less often? For Sinclair, it started with a study showing that the lifespan of dogs could be increased by reducing their caloric intake. This study inspired Dr. Sinclair to pursue his research on aging, where he has since found similar results in yeast. Theres a genetic pathway that gets triggered by low energy, says Sinclair. We consume less energy and activate enzymes called sirtuins by consuming fewer calories.

At his lab at Harvard Medical School, Dr. Sinclair and his team found that low energy activates sirtuins by causing our cells to make NAD+ (nicotinamide adenine dinucleotide), which sirtuins use as fuel. NAD+ was shown to increase the lifespan of yeast, which is one of the reasons why so many people now take NR (nicotinamide riboside) and NMN (nicotinamide mononucleotide) supplements, which boost NAD+ levels.

In addition to sirtuins, another molecule important for longevity is mTOR (mammalian target of rapamycin), except this one is better if not activated. Many animal studies show that decreasing mTOR increases lifespan. Sinclair explains that this is due to autophagy, where old proteins are recycled to make new ones. In humans, drugs that inhibit mTOR, like rapamycin, boost immunity and cause biochemical changes that mimic fasting and predict longevity.

The final longevity molecule discussed by David and Matthew was AMPK (AMP-activated kinase), an enzyme that goes up in response to low energy. One function of AMPK is to make more mitochondria, which decrease as we age and are vital for cell survival. In humans, the type 2 diabetes drug metformin activates AMPK and has been shown to reduce age-related disease.

We must fast to eat less often and regulate sirtuins, mTOR, and AMPK. Dozens of human studies have shown that fasting is beneficial for longevity. A Baylor College of Medicine study showed that fasting improved blood pressure, reduced BMI, decreased weight circumference, and, importantly, Sinclair says, upregulated DNA repair proteins. He explains that diseases like type I diabetes, multiple sclerosis (MS), and even cancer benefit from fasting.

Those three defense components [sirtuins, mTOR, AMPK] of the cell take care of the body, not just for aging, but to fight diseases in young people, middle-aged, and genetic diseases, says Dr. Sinclair.

David and Matthew go over three primary ways of fasting: the fasting-mimicking diet, intermittent fasting, and time-restricted feeding.

The fasting-mimicking diet involves lowering mTOR activity by reducing the consumption of branched-chain amino acids. For this diet, the time window for eating isnt as rigorous. Sinclair says, you want the body to be in a state of perceived adversity. He explains that in a clinical trial, the fasting-mimicking diet was shown to help cancer patients survive and get over chemotherapy quicker.

Intermittent fasting is going longer than a day without eating. This can go on for days or weeks, although Dr. Sinclair says, he wouldnt go longer because youll start chewing up your muscle. These long fasts turn on autophagy. Once youve gone beyond three days, your metabolism switches into whats called chaperone-mediated autophagy, the deep cleanse.

Time-restricted feeding, which involves not eating for at least 16 hours within 24 hours, is Dr. Sinclairs preferred fasting method. Sinclair explains that your liver will start making glucose at a steady level after a few weeks, so there wont be large spikes of insulin that put you in a glucose deficit and make you tired.

Which fasting method is best? David and Matthew proclaim the importance of genetics when it comes to fasting. A mouse study showed that caloric restriction shortened the lifespan of more mice (based on genes) than it lengthened. This means that caloric restriction probably does not work for everybody. Sinclair also says that fasting isnt easy, but its worth it. The trick, he says, is to fill yourself with fluids.

For me, constant coffee, tea, hot water, all the way through the day. Being hydrated and filled with liquid takes away any feeling of hunger.

In the last portion of the conversation, David and Matthew go over what we should eat to live longer. First, they go over what not to eat: sugar and meat.

Dr. Sinclair says that sugar is bad because it will reduce longevity, lead to type 2 diabetes, and possibly cause cardiovascular disease. It also shuts off AMPK and sirtuins. In other words, with high sugar, your defenses against disease and aging are minimal.

The Harvard scientist explains that red meat is non-beneficial. It is suitable for athletes or bulking up, but when looking at the evidence, high protein, carnivorous, red meat-based diets are not beneficial for a longer lifespan. High protein will shut off sirtuins, and the branched-chain amino acids in meat activate mTOR, inhibiting autophagy.

What should we eat? Dr. Sinclair himself is now a vegetarian if that tells you anything. Also, in the 2013 Adventist Health study, it was calculated that vegetarians live longer than non-vegetarians. Additionally, in a study on women, the Mediterranean diet (mostly vegetarian with some fish) decreased biological aging.

That fasting or eating the right foods, like the Mediterranean diet not just to slows down the ticking of the clock, but probably reverses your age is a mind-blowing concept, says Dr. Sinclair.

Why are plant-based foods good for us? Dr. Sinclair and Dr. Konrad Howitz published a paper in Nature showing that plants contain molecules called polyphenols, which activate the sirtuin enzyme Sirt1 and cellular pathways important for health and longevity.

As told by Dr. Sinclair, the takeaways of this podcast are to (1) eat less, (2) avoid sugar, (3) reduce meat intake, and (4) eat more of a plant-based diet, like the Mediterranean diet. He mentions that a study of elderly subjects in Spain showed that you could change your diet until the age of 80 and still get the benefits, so its not too late for many of us to change our eating habits to help us live longer lives.

Read more from the original source:
David Sinclair: How to Change Your Diet to Live Longer - NAD

There is no benefit to eating in a narrow window.

Thats according to Dr. Ethan Weiss, a diet researcher who spoke with The New York Times about a new study published in The New England Journal of Medicine, which concluded that popular time-restricted diets have no tangible impact on weight loss. Researchers split 139 obese volunteers into two groups the people in one group were only allowed to eat between the hours of 8 a.m. and 4 p.m., while the others were encouraged to eat at any time of the day. Each group observed the same calorie range: 1,200 to 1,500 a day for women, 1,500 to 1,800 a day for men.

By the end of the study (which lasted an entire year), both groups had lost an average of 14 to 18 pounds. There was no difference in weight-loss success, and no tangible disparity in secondary biometrics either. Results of analyses of waist circumferences, BMI, body fat, body lean mass, blood pressure, and metabolic risk factors were consistent with the results of the primary outcome, according to the study.

These findings might come as a bit of a shock to intermittent-fasting devotees, whove been instructed by YouTube influencers to skip breakfast, cut out nighttime snacking and stuff the entirety of ones consumption into an eight-hour window. To be clear, the authors arent saying that method isnt effective in promoting weight loss theyre just confirming the fact that it doesnt work any better than purposeful eating spaced out evenly throughout the day.

Ultimately, calorie restriction is the ace in the hole, not time restriction. Most of the scientific support for time-restricted eating was already somewhat flimsy (focusing on the concept that ones metabolism is most active during waking hours). This study reorients the focus to the importance of simply eating less.

Considering what we know about stringent diets far too often, they can trigger a what-the-hell effect, where the dieter steps out of line once, and then decides to dive headfirst into binge eating some conscious calorie restriction seems a better recipe for success than banning breakfast. Interestingly, Weiss who has done similar research as this new study out of Guangzhou, China actually used to observe time-restricted diet himself. Hes since abandoned it.

This study also calls to mind some wisdom from Harvard geneticist Dr. David Sinclair, who spoke to us about the shaky premise of time-specific intermittent fasting a couple years ago.

One other thing: people claim that there is an optimal intermittent fasting protocol. The truth is, we dont know what the optimal is, he said. Were still learning, and its individual. There are individual differences in all of usWe do know that if yourenever hungry, if youre eating three meals a day and snacking in between, thats the worst thing you can do. It switches off your bodys defenses. Some fasting is better than none.

While this study assessed calorie restriction through the paradigm of short-term weight loss, Dr. Sinclair runs a lab that obsesses over lifespan and longevity. Take it from the man who knows what it takes to live to 100 its crucial that you cut back on chomping. Just dont feel compelled to do so at exact hours of the day.

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Don't Listen to Intermittent Fasting Influencers, The Science Doesn't Back It Up - InsideHook

While David Sinclair might be best known for his shorter-distance mountain running, his second place at the 2022 Canyons by UTMB 100k shows his competitive diversity. In our first interview with him, David gives us the blow-by-blow of his all-race duel with Adam Peterman, the experience of sharing his Western States 100 Golden Ticket with fourth-place Rod Farvard, and where else well see David compete in 2022.

For more on what happened at the race, check out ourCanyons 100k resultsarticlefor the play-by-play and links to other post-race interviews.

iRunFar: Meghan Hicks of iRunFar. Im with David Sinclair, the second-place finisher of the 2021 Canyons Endurance Runs by UTMB 100k. Hey, David.

David Sinclair: Hi, Meghan. Thanks for being out there and covering the race today.

iRunFar: Yeah. That was really fun. We usually try to do these interviews in person, but you live over the pass in Sierra Nevada and you went home and scrubbed the poison oak off your legs after the race.

Sinclair: Yeah. Im pretty beat up and wanted to get home and shower.

iRunFar: When you live that close, I would go too.

Sinclair: Yeah, its pretty nice to have it right in the backyard there.

iRunFar: Yeah. You had a heck of a race today. How do you feel about it?

Sinclair: Im pretty ecstatic at how it went. Its always tough moving up in distance. Id never raced over six and a half hours and 50 miles before. So, this was the most vert and just the hardest, most competitive ultra Id been in. So I was really psyched when I ran strong pretty much the whole way. We were running well under course record pace the whole first two thirds of the race. And I kept thinking, I know this is going to catch up with me eventually. And it did right about halfway up the Deadwood climb. I started tightening up and had a couple little dark miles as I was thinking maybe Im going to cramp up and have to just walk it all the way in. But I was able to hang on pretty well.

iRunFar: So, talk a little bit about the beginning of the race. Its one of those dark starts flying off the line, flying through the early morning type thing and the terrain is pretty runnable early. So maybe give us the rundown of the first 15 or 20 miles.

Sinclair: It was just a huge group, but right from the start 20, 25 guys Doing six-minute miles out there and its just pretty runnable, gradual downhill, that first four. And so my original game plan was to hold back and be patient, but I was feeling pretty good, so I found myself never too far off the front. Feeling good, trying to keep it in check a little bit. So it was a fun, big pack. A few people were getting ahead on the climbs and I find Im a pretty good downhill runner, so I kept getting a little behind on the early climbs and working my way back up on the rolling and gradual downhills. But it felt just really comfortable. It was fun to run in a group and just absolutely gorgeous morning with the cool weather and nice fog. Its cool as you get up above the river to look down. So just really fun running through Drivers Flat there.

iRunFar: Im really glad you got to see that scene because for us spectators, that fog in the American River Valley, and the sunrise, and the moon, was just unreal this morning.

Sinclair: Yeah. I couldnt ask for a better day for a race. The rain down there actually made it really nice, runnable. It didnt seem too muddy at all, and just crisp and cool, which was the nice thing for me. Because I living up in Truckee, I dont think I had maybe three runs that have been above 60 degrees so far this year. So it was a real blessing to have it be a nice, cool day.

iRunFar: Awesome. I think there was still a pack of five or six of you guys at Cal 2, 24 miles into the race, but then things really splintered on the climb up to Foresthill. Can you talk about that part from your point of view?

Sinclair: Yeah, it was a pretty close pack and I was running I found myself in the front through Drivers Flat, running with Adam Peterman and I think it was Daniel [Jones] from New Zealand and Adam was feeling good, so I let him do most of the leading and took the lead a couple times on some of the hills where I was feeling good. I was saying, Why not? At that point, I still felt really good, lets see what we can do. And we, working together, finally opened up a gap there into Foresthill. And I pushed right through without stopping at the aid station Foresthill, and finally found myself in the lead for a little bit. So down to the river crossing there, I could see Adam was just 30 seconds behind me.

Sinclair: And so, I pushed it up to Michigan Bluff and got a little bit of a lead there. And then finally about mile 40 coming to the Deadwood aid station, I started just tightening up and I look back and theres Adam again. And I go, Oh no. There goes my shot at the win. And he came just flying by me. So that was the darkest patch of the race there, the climb past the Deadwood aid station.

Sinclair: We hit snow for the first time and it was sloppy for a mile. And then I finally got a second wind on the way down, but I was really hurting the last 12 miles. So, luckily I had stashed some trekking poles in my drop bag at the Deadwood aid station and with the legs on the edge, I grabbed those trekking poles and just tried to use my arms as much as I could to get up the last nine-mile climb, which just felt like it kept going on and on. And I had no idea, I kept getting splits that I was 5, 8, 10 minutes back on Adam. And I was like, Okay, just keep on moving and try to hold on to second.

iRunFar: And it never became an issue of anybody behind you. Nobody ever Jared didnt get close, I dont think.

Sinclair: He was pretty close at the end there. I was never really getting any good splits. So I had no idea how close he was.

iRunFar: You were running a little scared or

Sinclair: I was just running as far as I could without The last four miles there, back in the slush, it was these icy cold puddles and your tight legs. So, the icy cold water, youre like, How hard can I go without making my legs totally seize up? So I never really looked back. I just kept my head down and kept using my arm as much as I could to get to the finish and kept getting, Okay, its two miles to finish. I think I can do this. I think I can do this. And then, it felt like it was a minute or two and he came across and I was like, Oh, that was closer than I realized. If there was much further, I think he wouldve had me.

iRunFar: Interesting. A lot of people came to this race in search of a Golden Ticket, but there was a really cool moment at the finish line where you demured a little bit about the ticket and then you handed it over to fourth place finisher Rod Farvard. So you were not seeking a Golden Ticket at this race, you were here for other things.

Sinclair: I mostly wanted to do it because its in my backyard, its such a cool, competitive race. To get a little experience moving up to a 100k and try it out was my main goal. And I knew that I had a shot at top three and I was like, Oh, its tempting. I definitely want to run in Western states in the future, but Im already planning to try to run the Broken Arrow races, even closer to my backyard, three miles down the road. And maybe going to try to go to Europe and run Marathon du Mont-Blanc. So, Ive got a bunch of cool things on the calendar.

Sinclair: So, I think Western States will have to wait. And so when I saw Rod come across the finish line having an awesome race I think hed passed one or two people on the final climb to move up into fourth and hes really wanting to run Western States. So when I saw that I was like, This is the right thing to do. I dont need to go home and think about it for two weeks. And its the right decision for me to wait. Hopefully in the future, Ill be able to get into Western States and give it a real shot.

iRunFar: That was a really cool moment. It was win-win for everybody and it was a really fun to spectate that type of thing. You dont always get to see that type of interaction. That was really cool.

Sinclair: Yeah. As soon as I did it, I knew it was the right call to see the smile and the joy in his face. So, I was based on how I felt coming across the finish line, I was like, 40 more miles plus. Im not someone who likes the heat, so I dont know. Yeah. But good luck to Rod. Ill be rooting for him.

iRunFar: Thats awesome. Last question for you. You said instead of States, your 2022 is going to include the Broken Arrow races, Marathon du Mont-Blanc. What else are you going to do this year?

Sinclair: Yeah, everythings a little up in the air. Kind of depends how the legs come around and how everything is feeling. I might do the Speedgoat in July, its one of my favorite real mountain races, so signed up for that. And then Ill probably try to finish the three races out of the Golden Trail Series. So, since there are two in the US this year, thats a great opportunity. So, Im going to try to do the Pikes Peak ascent and then the race down in Flagstaff, Sky Peaks. So those are the big ones on my agenda. Might apply or try to see if I get a spot on the Worlds [World Mountain & Trail Running Championships] team too.

iRunFar: Right on. You got a busy year.

Sinclair: Yeah. So lots of races on the calendar. So, theres lots of great races to do.

iRunFar: Plenty to do. Well, congratulations on your second-place finish at Canyons 100k today. That was really fun to watch.

Sinclair: Thanks so much, Meghan.

Continued here:
David Sinclair Post-2022 Canyons by UTMB 100k Interview - iRunFar

David Sinclair gained a lot of popularity with his recent appearance on the Joe Rogan Experience, especially as he discussed such a poignant topic as life extension.

But is anti-aging something we can consider?

Can we fight death?

Not exactly. We can fight the negative effects of aging; we can look younger, and feel better for longer periods of time.

Thats Davids promise.

In the latest news, Sinclair, along with other European and US researchers has established the Academy for Health and Lifespan Research.

And, although hes 50 years old, his biological age is 31.

His antiaging research, his energy, and his focus, plus his appearance could convince anyone that what hes saying is legit.

However, remember to consult your GP before trying anything because all these products may interfere with pre-existing conditions.

RECOMMENDATION (Good For Daily Energy & Longevity)

In My Personal Experience & According to Countless Anecdotal Evidence It Provides Energy and Vigor Throughout The Day & Scientifically Shown to Raise NAD Levels. Now. (.).

David Sinclairs 1 gram of NMN and 0.5 g of resveratrol in the morning is mixed with yogurt; Studies showed that resveratrol absorption was 5 times lower if without fat. He doesnt mention a specific brand David takes the products below. He does take the resveratrol leftover from clinical trials. He prescribed some of these molecules to his mom and dad too, and even his family dogs!

Below are 3 longevity supplements David takes: Metformin, NMN, and Resveratrol, and more

NMN and Nicotinamide Riboside elevate your NAD levels. (Tru Niagen is The Best Replacement for MNM, it is considered to be more effective in raising NAD levels. I recommend considering Tru Niagen (Nicotinamide Riboside) products instead of NMN)

NAD helps your body make more energy. When you age, your cells make more NAD.

So not only do you feel more tired, your cells cant function properly because they dont have the energy they need.

Thats why David advocates supplementing with NMN to increase your NAD levels, even though theres no scientific consensus on this either.

David mixes his NMN into yogurt, so you need to find a powdered version.

Alive By Nature NMN Sublingual Powder is one of the best NMN powders on the market. Its 100% natural and vegan, with over 99% purity, no GMOs, and no gluten.

It works better if you place it under your tongue, though. The belief is that way the NMN can enter your bloodstream immediately, bypassing the liver, although this approach isnt fully researched yet.

The only downside is that quality NMN like this one is quite expensive, especially if you want to take 1g/ daily like Dr. Sinclair.

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Remember how everyone used to be hyped about red wine? Thats because of all the resveratrol found in the grape peel.

It was assumed that because grapes have this anti-aging substance in their peel, you can drink red wine and youll live a longer, healthier life.

Now we know thats not the case because youd have to drink hundreds of bottles of wine per day for resveratrol to work.

Thats how concentrated resveratrol supplements emerged. That is controversial, but well discuss that below.

We, the plebe, have to look on Amazon. To make sure you get a product thats similar to what he is using, you can read a paper published by one of his companies, Sirtris Pharmaceuticals, which was testing micronized resveratrol.

Micronized resveratrol increases the blood resveratrol levels almost four times.

As per these podcasts notes at Rich Roll, he recommends RevGenetics M98 Micronized Resveratrol. This is a legit company that has been selling resveratrol supplements since the early 2000s.

This product is micronized, so the molecules last longer in your bloodstream.

The powder form is user-friendly, as you can mix it with your shakes or yogurt.

With a 98% purity and high potency, the only downside of this supplement is how much it costs.

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Vitamins D3 and K2 are both involved in proper calcium absorption in your body. That way, calcium can go straight to your bones instead of blocking your arteries.

Sports Research Vitamin K2 + D3 with Organic Coconut Oil is one of the best choices that I discovered.

These concentrations mean that each capsule is very potent and efficient.

Keep in mind that the DRA for vitamin D3 is 600-800 iu per day, but vitamin D3 is easily excreted through the urine, so you need a bigger supplementation.

Even so, consult your GP before taking a D3 supplement, especially if you have pre-existing conditions.

Your GP might prescribe anywhere between 1000 iu to 5000 iu daily.

That said, this supplement:

The only con is possible bloating, but thats just the effect of D3. This supplement from Sports Research causes fewer GI problems than other D3 supplements on the market.

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Metformin is not a new appearance in the pharmaceutical market. Medical practitioners have known about metformin for a century, and they began studying it in the 1950s.

A plant-based drug, metformin is extracted from French Lilac, and its used in managing diabetes, considering it can decrease blood glucose.

Considering that metformin has all the advantages, and none of the risks, its no wonder that it looks appealing to fight aging.

All the other anti-aging products are nowhere near this tested and with so much patient-related data.

Can metformin fight old age?

Metformin is involved in the AMPK cellular pathway activation, which leads to:

Metformin can improve your metabolism, keep your cells healthy, and eliminate unhealthy ones.

However, metformin is a prescription drug, and most doctors prescribe it only for type 2 diabetes, not for general health and longevity.

Dr Peter Attia write on metformin and exercise. Really interesting. Do not take it the same day/time as your exercise!!!

In a podcast with Joe Rogan, he says hes been taking statin since his twenties because he has high cholesterol in his family.

Statins are prescription drugs that:

Side effects include:

These side effects are more common for over 65-year-old females and people with diabetes.

Statins interact with grapefruits, which block certain enzymes that help your body metabolize statins.

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Dr. Sinclair explains how NMN supplements work in a Joe Rogan Experience podcast.

He explains that diseases and age-related deterioration are caused by certain genes, called sirtuins.

NMN (nicotinamide mononucleotide) is a type of molecule that activates sirtuins, meaning NMN supplements can prevent disease, give you more energy, and reduce the negative effect of aging.

NMN boost NAD levels, and sirtuins need NAD to work properly.

NAD, aka nicotinamide adenine dinucleotide, is a coenzyme that assists your metabolism, so your cells have more energy to function and to fight diseases.

People cant take NAD directly because its a larger molecule that cant be metabolized easily. NMN is smaller, so its easier to absorb.

David has been taking 1g of NMN/ day for the last three years.

Studies show that the risk-free dose is 1-2g/ day. Some side effects can include mild GI distress, tiredness, and light headaches.

Benefits:

Apart from taking all of the products mentioned above, David does intermittent fasting. He mentions both on his blog and in his book called Lifespan: Why We Ageand Why We Dont Have To that you can live longer if you dont overeat.

He believes that old age is a disease that can be treated through nutrition. Intermittent fasting and calorie restriction improve your metabolism.

As such, your cells have more energy to keep the healthy ones alive and to kill the unhealthy ones. Accelerated metabolism also reduces inflammation and oxidative stress, which have been linked to chronic diseases.

David also exercises frequently:

David recommends using sauna and cold baths together, to accelerate your metabolism and improve heart function.

While David generally tries to get all the vitamins and minerals he needs from his diet, he does still take some supplements daily. Specifically, hes talked about taking:

In Davids book Lifespan, he mentions taking vitamin D3 daily. Vitamin D is a vital micronutrient and is thought to exercise an important effect on at least 200 of our genes. Its relatively scarce in foods, and so we rely on sunlight for producing adequate quantities. If youre not getting much sunlight, then it can be necessary to supplement it.

David doesnt name on the record what brand he uses, or how much he is taking, he discusses in the podcast with famous Dave Asprey that he needs 2,000iu per day at the minimum.

David suggests taking Vitamin K2 in his book.

Vitamin K is a crucial micronutrient that performs a vital role in the capacity to form blood clots and to move calcium throughout the body. It comes in two various forms, K1 (phylloquinone) and K2 (menaquinone). K1 is the most plentiful in a western diet, found in leafy green vegetables. Vitamin K2 is located in fermented foods, which are less prevalent in a western diet. A source thats unusually high in K2 is fermented soya beans.

Sadly, many people are low in K1, and hence may have low levels of K1 to maintain sufficient calcium transport

So where does the vitamin K2 supplementation come in?

Vitamin K1 is used in the liver, and K2 appears to be prioritized for use in the periphery, which will support calcium transport.

David suggests taking alpha-lipoic acid. Not to be confused with alpha-linolenic acid that is a source of omega-3 fatty acids, frequently found in seeds. Alpha-lipoic acid is found naturally in a specific food, and when ingested, is used in the cells as a cofactor in mitochondrial energy metabolism.

David states in the interview with David Asprey that he gets Coenzyme Q10 due to the fact that he is taking statins. He doesnt explain why he takes Q10, but hes likely referring to a study that proposes that statins may decrease coenzyme Q10 levels in the blood. He just states that he gets a large pill daily. Q10 supplements are generally taken in the 100 to 200mg range.

Davids diet is shaped by his caloric restriction principle. He also avoids foods that impact metabolism and affect the glycemic index.

As weve mentioned before, NAD is a helper molecule that fuels some of the most important biological processes in your body, like:

NAD levels plummet with old age. Very low NAD levels are correlated with Alzheimers, diabetes, cardiovascular issues, and vision impairment.

Thats why taking NAD precursor supplements like those manufactured by Metro Biotech can help you age gracefully.

In the words of David, resveratrol steps on the accelerator pedal of the sirtuin enzymes.

In the same JRE podcast cited above, David explains that there are plenty of mice studies that show resveratrol improves their health/longevity and lengthens their lifespan.

David says that you need NMN for resveratrol to work because NMN is the fuel that sirtuins need. You cant accelerate sirtuins if they dont have enough energy to work.

The problem with sources is that NMN is not naturally occurring. The human body normally makes glycine, a type of amino acid that is similar to the NMN in order to produce energy. While there is a relatively small amount of glycine in our body, there is sufficient to produce a very mild, long-lasting antidepressant effect, but not enough to produce a noticeable improvement in mood. Similarly, those seeking a more powerful NMN effect may want to look at the pharmaceutical brands that are available, such as Evista recommended by Rhonda Patrick. In many ways, NMN is similar to the way that omega-3 fatty acids can reduce inflammation in the body. While we can consume the omega-3 fatty acids ourselves, the body cannot make NMN on its own and thus must rely on diet and supplements to obtain them. To supplement with NMN, it is best to start with a relatively low dosage of less than 100mg per day, which you can digest without the body having to break it down into a different form.

Ways to get a glucose-lowering effect from eating plant foods. A good habit to incorporate into your lifestyle is consuming protein with each meal. Protein promotes weight loss by increasing metabolism. For most people, a combination of protein and plant foods is most effective for weight loss. In addition, to help minimize carbohydrate cravings, a protein snack can be a good idea every 3 hours. I know of several things that have helped people get some lower-glycemic foods in their diet. Some of these include: Tracking and logging food intake. Dietary fats and protein control. Eating organic foods. Fiber. Lots of vegetables. When working with clients, I like to remind them that weight loss and health are better than any kind of diet. Even a diet that may seem good on paper is not good for long-term health. You cant fix your overall health with a diet unless you add exercise, physical therapy, and other lifestyle modifications. It takes a lifestyle change to heal, and a diet wont necessarily do that.

Evidence that dietary Nicotinamide mononucleotidesupplementation with nicotinamide riboside (NR) might be an effective strategy for modulating glucose-6-phosphate cycle kinase in type 2 diabetes has sparked a great deal of enthusiasm.2,4,10,15 In particular, clinicians have been encouraged by the recent findings of Lozada et al8 who found that NR supplementation (3 g/day) significantly improved glycated hemoglobin (HbA1c), glucose tolerance, and fasting glucose (BG) in individuals with impaired glucose tolerance (IGT), following 10 weeks of treatment.3 Other recent trials have shown NR is an effective strategy for insulin and glucose control in T2D and type 1 diabetes in children, adolescents, and adults,3,4,6,10,12,14,1519 and has also been found to have beneficial effects.

Folk medicine suggests that the consumption of bonemeal can help the body fight age and protects the organism from diseases. They are popularly called bioneers in India. Some research has also revealed that this substance can slow down the progression of heart and blood vessel diseases and can even prevent the occurrence of high blood pressure. Even more than that, the people who are consuming this low-calorie food have also been found to be able to lower their risk of cancer.

Given the above-mentioned facts, you should definitely take a closer look at the ginseng and beechwood extracts. According to a new study published in the journal Nature Medicine, they have the ability to extend the life of rats by 30 percent. In addition, the rats that were given a mix of these ingredients have also shown a reduction in the number of carcinogenic compounds in their urine, cholesterol levels, and even blood sugar. So, how exactly can these substances prolong our lifespan? Well, they contain compounds called flavonoids. They protect your cells from damage and have anti-inflammatory and antioxidant properties.

Were learning more about the health of the body in order to become the healthiest, leanest, and happiest that we can be. The truth is, we really dont know all that much. The human body is the most complex machine in the world, and to fully understand and reverse aging, wed need to understand the secrets behind every single aspect of the process. However, thats not the case. 1 cup of coffee in the morning, green tea after that. This I especially troubling to many because it means that as we age, we continue to experience a body that grows more complicated in order to stay functional for longer than we would like. One fact of the family history is for certain: for as long as the human race is on this planet, it will need to know about the body.

If the body gets sick, it keeps us alive. It takes care of us. One of the best ways to achieve health, happiness, and longevity is by strengthening the body and nutrition. Consider the health benefits of eating an alkaline diet. Benefits of an Alkaline Diet. Simply put, an alkaline diet is a diet that is alkaline in nature. This means that you are eating foods that arent too acidic. As we age, our bodies become more acidic which can be caused by inflammation.

Trying to think of ways to enhance your health by taking a supplement of something is certainly great, but it also usually comes with a risk that youll be able to make a very good excuse not to take the vitamin or supplement in the first place. Now, there are situations when it is advisable to take two or more supplements at the same time, but most of the time, you should try to limit your supplement with methyl groups to only one of them, or maybe, the supplements are supposed to work as a combination.

If you are taking another supplement, be careful to take it at the same time, preferably at the same time every day, if not right after you take your first supplement. A lot of different types of vitamins can affect each other, and if you put them together, they can become more effective than they would be on their own.

Yes, the medical consensus is that resveratrol is safe.

However, theres no consensus on whether or not it works.

In 2006, he co-wrote a paper on the benefits of resveratrol. Resveratrol is a stilbenoid found in the skin of grapes in low amounts. Studies have shown that resveratrol can reduce the risk of heart disease, cancer, and neurodegeneration. David Sinclair believes that resveratrol works synergistically with NMN. Resveratrol is needed to activate the sirtuin genes.

Excerpt from:
David Sinclair Supplements (2022 List) | Brands for Anti-Aging!